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Dissertations / Theses on the topic 'Zikav'

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Published: 14 March 2023

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1

Nastasja, Palombi. "Broad antiviral compounds targeting viral envelope: synthesis and pre-clinical studies." Doctoral thesis, Università di Siena, 2020. http://hdl.handle.net/11365/1096254.

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The majority of viral pathogens that cause emerging and re-emerging infectious diseases are membrane-enveloped viruses. In this thesis work a new series of antiviral compounds, with 1H-pyrrol-methylene thioxodihydropyrimidine structure, were designed and synthesized. They were endowed with antiviral activity on enveloped viruses, likely ZIKAV, DENV-2, and five influenza virus strains, including the pandemic H7N9 model. The intriguing mechanism of action was pursued and confirmed the hypothesis of compounds able to intercalate in the viral lipid envelope membrane and to oxidize phospholip
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2

Persona, Michelli Romanoli. "Estudo comparativo entre testes sorológico para diagnóstico específico da infecção pelo vírus zika." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17138/tde-19072018-134353/.

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No Brasil a confirmação do primeiro caso de febre zika, resultante da infecção pelo vírus zika (ZIKV), foi no primeiro semestre de 2015, na região nordeste. Os achados característicos eram de uma doença que apresentava sintomas semelhantes aos sintomas causados pelo vírus dengue (DENV), porém mais amenos, sendo inicialmente denominada de \"Síndrome Dengue-Like\". Além desta semelhança no quadro clínico, ZIKV e os DENV são arboviroses endêmicas no Brasil e pertencem à mesma família viral, sendo muito próximos filogeneticamente, resultando em uma forte reação cruzada entre os anticorpos induzido
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3

RODRIGUES, F. M. G. S. "DIVERSIDADE Genética do Zika Virus no Estado do Espírito Santo." Universidade Federal do Espírito Santo, 2018. http://repositorio.ufes.br/handle/10/7119.

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Made available in DSpace on 2018-08-01T21:35:03Z (GMT). No. of bitstreams: 1 tese_12070_Dissertação_Fernanda Mariano Garcia.pdf: 3239009 bytes, checksum: d9dfe15fc9ef8127dc0144cec5fa3160 (MD5) Previous issue date: 2018-03-06<br>O Zika virus (ZIKV) é um arbovírus do gênero Flavivirus pertencente à família Flaviviridae. Duas principais linhagens são reconhecidas, Asiática e Africana, sendo a linhagem Asiática encontrada no Brasil. Os sintomas da infecção de ZIKV geralmente são brandos, mas existem relatos de casos de óbitos e manifestações neurológicas. Variações genéticas virais estão relacio
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4

Holt, Jim. "Zika Virus." Digital Commons @ East Tennessee State University, 2016. https://dc.etsu.edu/etsu-works/6468.

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5

Zvenigorodska, G., and Iu Vyzhga. "Congenital Zika syndrome." Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/64469.

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Zika вірусна інфекція – актуальна проблема сьогодення, що має значні негативні наслідки у вагітних жінок. Вроджений Zika синдром характеризується в першу чергу мікроцефалією, аномаліями розвитку, порушенням зору і слуху.<br>Zika virus infection is among the nationally notifiable diseases all over the world. In March 2016, the WHO reported that Zika virus was actively circulating in 38 countries and territories. Spain has recorded the first case in Europe of a baby born with the microcephaly birth defect associated with the Zika virus in 2016.
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6

Neel, Kelly Lynn, and Kelly Lynn Neel. "Zika Outbreak Concern in Border Communities: Zika Virus Dissemination Prevention Program." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625108.

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The rapid and vast expansion of Zika virus in the Americas has heightened interest in members of the health sciences community, including public health agencies and officials. Concern of a future Zika outbreak in the United States is imminent. Prior studies, in combination with surveys administered by the author, suggest that mosquito avoidance behaviors could use improvement, especially in areas of high susceptibility of mosquito-borne illness dissemination. Border communities often face more health-related complications due to lack of appropriate resources, indicating the need for preventive
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7

Lee, Wai Suet. "Discovery of Novel Markers of Virus Transmission by Mosquitoes." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/390018.

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Mosquito-borne diseases are responsible for significant human morbidity and mortality throughout the world. Current vector control strategies have been impeded by mosquitoes acquiring resistance to insecticide. Therefore, development of new vector control strategies is urgently needed to complement current strategies. In this thesis, efforts have focused on characterizing the glycan-lectin interactions of Ross River virus (RRV; Togaviridae: Alphavirus) with their mosquito vectors. RRV is the most common arbovirus in Australia that causes clinical manifestations including arthralgia and myalgia
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8

Izuagbe, Rhys E. "A prostate cell line model of persistent Zika virus infection." Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/129570/1/Rhys_Izuagbe_Thesis.pdf.

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This study investigates how Zika virus can persist and replicate in the human prostate. It establishes a human prostate cell line model to address this question and examines the replication of three different virus strains in the cells. It also characterises the gene expression changes that occur in prostate cells during persistent Zika virus infection.
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9

Towers, Victoria, and Victoria Towers. "Zika Virus: Patient Education Recommendations." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/625230.

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As the current growing threat to maternal-fetal health, the most recent and largest outbreak of the Zika virus has introduced the devastating fetal effects of microcephaly and other central nervous system deficits. Therefore, the need for appropriate recognition, treatment, management, and prevention of the Zika virus prompts the necessity for further education and high quality level research to be conducted and utilized. A search of the literature using the databases PubMed, UptoDate, and CINAHL was conducted for articles published between 2009 and 2016. In addition, key informant inter
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10

Chow, Wai-chun. "On the relationship between the prose and comics of Feng Zikai Feng Zikai san wen yu man hua chuang zuo guan xi yan jiu /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40717380.

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11

Maucourant, Christopher. "Caractérisation du découplage des fonctions des cellules natural killer au cours des infections par les virus de la dengue, du zika et du chikungunya Control of Acute Arboviral Infection by Natural Killer Cells HLA-C-restricted viral epitopes are associated with an escape mechanism from KIR2DL2+ NK cells in Lassa virus infection." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS274.

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L'histoire récente à été marquée par des épidémies récentes de dengue (Denv), Chikungunya (CHIKV) et Zika (ZIKV). Bien que ces maladies soient largement asymptomatiques, elles peuvent générer de sérieuses complications comme des formes chroniques d'arthralgies et peuvent causer des hémorragies pouvant conduire au décès (Majoritairement DENV), des microcéphalies (Maj. ZIKV) et des Syndromes de Guillain-Barré (Zikv et Chikv). Ces épidémies récentes ont poussé l'OMS à classer ces maladies comme maladies à déclaration obligatoire. A ce jour aucun traitement spécifique existe contre ces maladies re
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12

Levy, Blitchtein Saul, and Valle Mendoza Juana Mercedes Del. "Zika virus is arriving at the American continent." Elsevier B.V, 2016. http://hdl.handle.net/10757/620620.

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13

Messias, Thiago Silva. "Investigação sorológica, molecular e filogenética do Zika virus." Botucatu, 2019. http://hdl.handle.net/11449/181074.

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Orientador: Virgínia Bodelão Richini-Pereira<br>Resumo: O Zika virus (ZIKV) é um flavivírus transmitido por mosquito que causa Febre Zika e está associado às Malformações Congênitas e Síndrome de Guillain-Barré integrando a lista de agentes etiológicos que são um problema de saúde pública internacional. Apresentamos uma investigação sorológica e molecular do ZIKV em amostras humanas na região de Bauru do estado de São Paulo, Brasil a fim de contribuir na determinação dos primeiros casos de infecção de ZIKV nos locais do estudo. Foi realizada a investigação sorológica por técnica de imunocromat
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14

Woolley, Michael E. "Development and Characterization of Reporter-Expressing Zika Viruses." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7225.

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In recent years, Zika virus (ZIKV) has garnered worldwide attention due to its epidemic spread throughout the Americas and due to the newly recognized link between ZIKV infection and neurological diseases, including microcephaly and Guillain-Barré syndrome. ZIKV is a mosquito-borne member of the genus Flavivirus, which includes the other prominent human pathogens Japanese encephalitis virus, West Nile virus, dengue virus, and yellow fever virus. Many questions about the biology of ZIKV and how it causes disease remain unanswered. Furthermore, there currently are no vaccines or licensed antivir
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15

Laureillard-Wendland, Marie. "Feng Zikai (1898-1975), peinture et littérature, image et texte." Paris 4, 2006. http://scd-rproxy.u-strasbg.fr/login?url=https://www.harmatheque.com/ebook/9782343135861.

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L’artiste chinois Feng Zikai (1898-1975) appartient pleinement à son époque en créant une forme de dessin rapide et simple parfaitement adapté à la presse, en plein essor dans la métropole moderne qu’est la Shanghai des années trente. Réalisé à l’encre et au pinceau, mêlant caractéristiques occidentales et chinoises, le manhua est un art que Feng considère lui-même comme situé à mi-chemin entre la peinture et la littérature, car porteur d’une signification que précise la légende. Celui-ci se combine bien souvent à l’écriture d’essais « familiers » (xiaopinwen), forme littéraire également libre
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16

Weilg, Claudia, Lucinda Troyes, Zoila Villegas, et al. "Detection of Zika virus infection among asymptomatic pregnant women in the North of Peru." BioMed Central Ltd, 2018. http://hdl.handle.net/10757/624624.

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Objective: To report an outbreak of ZIKV infection among asymptomatic pregnant women during 2016 in the city of Jaen, Cajamarca. Results: Zika virus RNA was detected in 3.2% (n = 36) of cases by RT-PCR. The mean age of patients positive for ZIKV infection was 29.6 years. 7 patients (19.4%) infected with ZIKV were in their first-trimester of gestation, 13 (36.1%) were in their second-trimester, and 16 (44%) were in their third-trimester. All of the infected pregnant women were asymptomatic. ZIKV infection remains a major public health issue that calls for constant epidemiological surveillance.
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17

Frejd, Rebecka. "Vad är känt om Zikavirusets spridning, dess kliniska bild, patogenes, morfologi, diagnostik samt behandling?" Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-65398.

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Zikaviruset är ett virus som fått stor uppmärksamhet i framför allt Sydamerika från 2015 och framåt då allt fler fall uppmärksammats. Detta arbete har utförts som en litteraturstudie med mål att sammanfatta kunskapsläget kring Zikavirusets morfologi, spridning, historia, komplikationer, diagnostik samt rådande behandlingsmöjligheter. Som källor används information från Folkhälsomyndigheten, CDC, PAHO och WHO samt MeSH-sökningar via PubMed. Viruset tillhör familjen Flaviviridae. Liknande andra virus i samma grupp kan infektionen ge feber, makulopapulösa hudutslag, konjunktivit, ledvärk, huvudvä
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18

Ruiz, Arroyo Víctor Manuel. "Structural and functional analysis of Zika Virus NS5 protein." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/671922.

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Zika virus (ZIKV) belongs to the Flaviviridae family and constitute an important public health concern since ZIKV infection produced devastating effects in new born infants. Flaviviruses present a positive sense single stranded RNA genome flanked by highly structured untranslated regions (UTR) carrying one open reading frame that codifies for three structural proteins (C, prM, E) and five nonstructural proteins (NS1-5). At the most C-terminal end, NS5 protein carries a RNA dependent RNA polymerase (RdRP) and a methyl transferase domain (MTase) for genome copying and 5’ capping activities of th
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Tillman, Jonas, and Robin Kristoffersson. "Experiencing Zika : A qualitative interview study of Brazilian nurses." Thesis, Röda Korsets Högskola, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:rkh:diva-2354.

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Background: Zikavirus was discovered in the 1950’s in the Zikaforest in Uganda, it is a vector borne flavivirus and its main carrier is the Aedes Aegyptimosquito. In 2015 ZIKV reached Brazil and from Brazil it has spread to 26 countries in the Americas. ZIKV is most known for its ties with Microcephaly, but the ZIKV has been linked to several neurological conditions including Guillian-Barré Syndrome. Very limited treatment is currently available for the complications and prevention is the most used method to combat the infection. Aim: The aim of this study is to describe the experience of Braz
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Guidry, Jeanine. "Designing Effective Messages to Promote Future Zika Vaccine Uptake." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/5017.

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The Zika virus is associated with the devastating birth defect microcephaly, and while a vaccine was not yet available in early-2017, several were under development. It is imperative to identify effective communication strategies to promote uptake of a new vaccine, particularly among women of reproductive age. Moreover, though the Zika outbreak has received much social media attention, little is known about these conversations on Instagram. The purpose of this dissertation, therefore, was to understand current Zika-focused communication on Instagram and to inform effective communication strat
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Santos, Francielle Martins. "Construção de uma Biblioteca de Anticorpos Anti-ZIKA Vírus." Botucatu, 2019. http://hdl.handle.net/11449/181094.

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Orientador: Flávia Hebeler Barbosa Trovão<br>Resumo: Bibliotecas conformacionais de anticorpos vem constituindo importantes ferramentas na investigação científica de imunoglobulinas expressas em diferentes situações biológicas incluindo patologias. O conhecimento e elucidação estrutural de anticorpos diferenciais produzidos em patologias distintas pode representar ferramenta molecular fundamental para a intervenção na fisiopatologia da doença; incluindo diagnóstico diferencial, identificação de biomarcadores, terapêutica baseada em imunoglobulinas para bloqueio de patógenos bem como, contribui
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Costa, Bruno Lucian Gonçalves da. "Uma simulação do espalhamento do Zika vírus na Flórida." reponame:Repositório Institucional do FGV, 2017. http://hdl.handle.net/10438/19492.

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周慧珍 and Wai-chun Chow. "On the relationship between the prose and comics of Feng Zikai." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40717380.

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Patricelli, Martina <1995&gt. "L'arte e la letteratura di Feng Zikai: una proposta di traduzione." Master's Degree Thesis, Università Ca' Foscari Venezia, 2019. http://hdl.handle.net/10579/15853.

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Feng Zikai was a well-known Chinese painter and cartoonist, he was the founder and the unique master of the so-called Chinese lyrical cartoon. He is better known as a cartoonist but he his more than a simple artist, he was an essayist and a translator too. Thanks to his style of writing and his unique technique of drawing his works became part of the most important Chinese periodical which let him to gain a good reputation in the art world. In writing this thesis i managed to translate fifteen of Feng Zika’s informal essays taken from the collection Yuanyuan Tang suibi 缘缘堂随笔 (Essays from the
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Bos, Sandra. "Undestanding the viral molecular factors involved in Zika virus pathogenicity in humans." Thesis, La Réunion, 2019. http://www.theses.fr/2019LARE0005.

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Le virus Zika (ZIKV) est un phénomène épidémiologique sans précédent qui surprit le monde entier. Pendant de nombreuses années, il fut considéré comme un virus anodin responsable d’une poignée d’infections humaines, auto-limitées et bénignes, en Afrique et en Asie du Sud-est. Mais, après des décennies de propagation silencieuse, une première épidémie éclata en Micronésie en 2007 - tel un signal d'alarme. Quelques années plus tard, une soudaine épidémie de ZIKV de plus grande ampleur se déclara dans les îles du Pacifique avant d'atteindre le Brésil en 2015. Au cours de cette période, Zika fut a
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Hamel, Rodolphe. "Biologie du virus zika dans les cellules cutanées et les astrocytes." Thesis, Montpellier, 2017. http://www.theses.fr/2017MONTT003.

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Le virus Zika (ZIKV), virus découvert pour la première fois à la fin des années quarante, est un arbovirus émergent récemment arrivé sous le feu des projecteurs à l’occasion d’une pandémie rapide à l’échelle mondiale. Appartenant à la famille des Flaviviridae, ce flavivirus est transmis par les moustiques du genre Aedes. Alors qu’on le croyait relativement peu pathogène, ce virus se révèle être la cause probable d’une vague de complications neurologiques, incluant l’apparition de microcéphalies et de syndromes de Guillain-Barré. De plus, il n’existe à l’heure actuelle ni vaccins ni traitements
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Provost, Joël. "Infection des cellules du système immunitaire par le virus Zika." Master's thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/31449.

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Le virus Zika est un pathogène qui a récemment retenu l’attention de la communauté scientifique suite à une importante éclosion en Amérique du Sud. Ce virus, peu étudié auparavant, peut causer des pathologies parfois graves chez les personnes infectées. Nous avons démontré que le virus Zika peut infecter les macrophages dérivés de monocytes. Plusieurs souches virales peuvent infecter les macrophages, mais certaines différences existent entre ces souches quant au taux d’infection et la cinétique de réplication. La réplication virale serait localisée autour du noyau de la cellule, comme ce qui e
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ANTUNES, M. N. "Comunicando o risco: um olhar sobre a epidemia de Zika." Universidade Federal do Espírito Santo, 2018. http://repositorio.ufes.br/handle/10/10334.

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Made available in DSpace on 2018-08-27T13:41:21Z (GMT). No. of bitstreams: 1 tese_12420_tese_michele_nacif_antunes.pdf: 2284184 bytes, checksum: e1a2364ab7cb967ec9996bed8ea69793 (MD5) Previous issue date: 2018-07-17<br>A comunicação de risco é definida como um processo de planejamento de comunicação de instituições públicas para enfrentar situações de crises ou riscos, que quase sempre se tornam eventos de mídia. Nos dias atuais, cada vez mais podem se tornar também eventos de mídia social. E, por isso, as mídias sociais devem ser consideradas no planejamento da comunicação diante de eme
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Bastos, Marcio Maciel. "Modelagem probabilística da dinâmica da Zika usando modelos hierárquicos bayesianos." reponame:Repositório Institucional do FGV, 2018. http://hdl.handle.net/10438/21991.

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Silva, Herculano da. "Migração de leucócitos para o sistema nervoso central na infecção experimental por vírus ZIKV." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-01022019-095421/.

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O vírus ZIKA pertence ao gênero Flavivírus e diversos trabalhos têm demonstrado que a infecção por esse vírus está associada com o desenvolvimento de anomalias congênitas fetais e doenças neurológicas como casos de microcefalia e de síndrome de Guillan-Barré. Com intuito de entender os mecanismos imunológicos de controle da replicação viral e na patogênese da doença, o objetivo do trabalho foi estabelecer um modelo experimental de infecção por vírus ZIKV em animais imunocompetentes e investigar a migração de leucócitos para o sistema nervoso central durante a infecção por esse vírus. Os animai
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To, Pui-yee Perry. "Feng Zikai's (1898-1975) Manhua on the theme of children /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21301153.

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Lopes, Aline de Siqueira Alves. "Acompanhamento clínico e nutricional de uma coorte de lactentes com síndrome da Zika congênita, nascidos em Sergipe, nordeste do Brasil." Pós-Graduação em Ciências da Saúde, 2018. http://ri.ufs.br/jspui/handle/riufs/9390.

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Introduction: At the end of 2015, zika virus became the protagonist of an epidemic of congenital anomalies never observed. The northeastern region of Brazil was the most affected. Congenital Zika Syndrome is characterized by severe microcephaly, critical brain damage, ophthalmologic, auditory, cardiac and orthopedic anomalies, as well as severe developmental delay with irritability, spasticity and convulsions. Owning to the fact that it is a new pathology, little is known about its long-term evolution, since affected children are aged around 3 years. Goal: To follow-up of a cohort of infants b
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Zancanelli, Amanda Madeira. "Infecção gestacional por Zika Vírus: desenvolvimento motor nos primeiros anos de vida, contexto ambiental e perfil epidemiológico." Universidade Federal de Juiz de Fora (UFJF), 2018. https://repositorio.ufjf.br/jspui/handle/ufjf/7234.

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Submitted by Geandra Rodrigues (geandrar@gmail.com) on 2018-09-04T12:29:27Z No. of bitstreams: 0<br>Approved for entry into archive by Adriana Oliveira (adriana.oliveira@ufjf.edu.br) on 2018-09-04T13:24:20Z (GMT) No. of bitstreams: 0<br>Made available in DSpace on 2018-09-04T13:24:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-07-19<br>No ano de 2015, o Brasil enfrentou um surto de infecção por Zika Vírus (ZV), principalmente na região Nordeste, sendo 907 casos em gestantes. Após o nascimento destes lactentes, foi confirmada a associação entre o vírus e diversas malformações congê
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Lin, Su-Hsing. "Feng Zikai's Art and the Kaiming Book Company: art for the people in early twentieth century China." Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1079634774.

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Thesis (Ph. D.)--Ohio State University, 2003.<br>Title from first page of PDF file. Document formatted into pages; contains xxxiii, 445 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: Julia F. Andrews, Dept. of History of Art. Includes bibliographical references (p. 317-251).
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Rodó, Rodríguez Carlota. "Impacte de la infecció per virus del zika durant la gestació." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/662618.

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Antecedents El virus Zika és un agent teratogènic amb tropisme predominant per al cervell fetal. S’ha demostrat que pot causar lesions neurològiques severes en fetus però es desconeix la incidència real de la infecció i la afectació fetal. Material i mètode Des del brot del virus del Zika a Brasil el novembre de 2015 es van estudiar de forma prospectiva totes les dones embarassades amb vincle epidemiològic a zona endèmica de virus Zika. Seguint el protocol de l’Agència Catalana de Salut Pública, es van utilitzar proves biològiques i serològiques per tal d’identificar les dones infectades.
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Moura, Lopes Luiz Henrique. "Trending health narratives : the Zika virus outbreak 2015-16 in Brazil." Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/61347.

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This study explores the intersections of social media and health communication, focusing on the trending narratives on Twitter during the 2015-16 Zika virus outbreak, in Brazil. It examines how social media data provides insights into current media practices, as a way of improving health communication strategies and literacy during epidemics. This project uses a qualitative study framework to illustrate the phenomenon under examination, drawing a theoretical thematic analysis as a method (Braun & Clarke, 2006). Findings from this thesis reveal how increases in Zika-related news commentar
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Krystosik, Amy Robyn. "CHIKUNGUNYA, DENGUE, AND ZIKA IN CALI, COLOMBIA: EPIDEMIOLOGICAL AND GEOSPATIAL ANALYSES." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1481111225042036.

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Muppalla, RoopTeja. "A Twitter-based Study for Understanding Public Reaction on Zika Virus." Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright151994467953523.

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Frank, Jordan C. "Development and Application of a Reverse Genetics System for Zika Virus." DigitalCommons@USU, 2018. https://digitalcommons.usu.edu/etd/7280.

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Zika virus (ZIKV) has emerged in many regions of the world, with infection outcomes spanning from no apparent illness to crippling nervous system disease. ZIKV and its close relatives, West Nile virus, Japanese encephalitis virus, dengue virus, and yellow fever virus are primarily transmitted by mosquitoes. Three ZIKVs were selected: MR-766 (Uganda, 1947), P6-740 (Malaysia, 1966), and PRVABC-59 (Puerto Rico, 2015), whose place of origin and time of isolation differ substantially. Stable, complementary DNA (cDNA) copies of the three ZIKV RNA genomes were cloned to examine the significance of vi
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Freitas, Alyne Aparecida Ferreira. "AVALIAÇÃO DO IMPACTO FAMILIAR EM PAIS DE CRIANÇAS DIAGNOSTICADAS COM MICROCEFALIA PELO ZIKA VÍRUS." Pontifícia Universidade Católica de Goiás, 2018. http://tede2.pucgoias.edu.br:8080/handle/tede/3925.

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Submitted by admin tede (tede@pucgoias.edu.br) on 2018-04-17T17:46:02Z No. of bitstreams: 1 ALYNE APARECIDA FERREIRA FREITAS.pdf: 750774 bytes, checksum: f4eb9631ba2e7c7ff4dcdee8b5719580 (MD5)<br>Made available in DSpace on 2018-04-17T17:46:03Z (GMT). No. of bitstreams: 1 ALYNE APARECIDA FERREIRA FREITAS.pdf: 750774 bytes, checksum: f4eb9631ba2e7c7ff4dcdee8b5719580 (MD5) Previous issue date: 2018-03-05<br>The objective of this study was to evaluate the family impact in parents of children diagnosed with microcephaly by Zika virus. This is a cross-sectional analytical study with a quantitat
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Grant, Alesha. "Functional Conservation of Interferon Antagonism among Flaviviruses| Zika Virus Targets Human STAT2." Thesis, Icahn School of Medicine at Mount Sinai, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10270604.

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<p> Flaviviruses are a diverse group of emerging arboviruses capable of infecting an extraordinarily broad range of vertebrate and invertebrate hosts. Nearly half of the viruses in this rapidly expanding genus have been reported to be pathogenic for humans, as well as other vertebrates. The spectrum of human disease includes asymptomatic and febrile illnesses, rash, arthralgia, encephalitis and hemorrhagic fever. The recent outbreak of Zika virus (ZIKV) has uncovered pathology in the form of microcephaly and Guillain-Barr&eacute; syndrome, cementing the importance of flaviviruses as emerging h
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Radic, Vesna. "Development of cell culture assays for identification of potential Zika virus inhibitors." Thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329420.

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Clé, Marion. "Etude du neurotropisme de deux arbovirus émergents : les virus Zika et Usutu." Thesis, Montpellier, 2020. http://www.theses.fr/2020MONTT024.

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Les virus émergents sont définis comme étant des virus gagnant de nouveaux territoires ou comme des virus connus mais ayant muté ou recombiné au point de devenir beaucoup plus transmissibles et contagieux dans la population. Ces virus posent des problèmes majeurs pour la santé publique car ils peuvent être à l’origine de maladies parfois inconnues et potentiellement graves notamment neuroinvasives. C’est le cas, par exemple, avec l’émergence récente de deux virus neurotropes : Zika (ZIKV) et Usutu (USUV). ZIKV a été responsable d’épidémies principalement en Polynésie Française en 2013 et en Am
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Saba, Villarroel Paola Mariela. "Epidemiology of central nervous system infections and of Zika virus in Bolivia." Thesis, Aix-Marseille, 2020. http://theses.univ-amu.fr.lama.univ-amu.fr/200424_SABAVILLARROEL_796lerwvy638nrfmjn965osdp469z_TH.pdf.

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Nous avons réalisé une étude prospective (nov-2017 à oct-2018) chez des patients boliviens hospitalisés suspectés d'infection du SNC pour identifier les plus courants étiologies et orienter les stratégies de diagnostic, de traitement, de prévention et de santé publique. Nous avons recruté 257 patients hospitalisés (20,2% VIH positifs), une étiologie infectieuse a été confirmée chez 49,8% des patients. Les principales étiologies chez les patients VIH positifs étaient Cryptococcus spp. (41,7%) et M. tuberculosis (27,8%) et chez les patients VIH négatifs, M. tuberculosis (26,1%) et S. pneumoniae
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Silveira, Roberta Maraninchi. "Localização subcelular do vírus da Zika durante a infecção em células humanas." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/17/17136/tde-13092018-105525/.

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O vírus da Zika (ZIKV) é um arbovírus emergente da família Flaviviridae, do gênero Flavivirus transmitido por mosquitos Aedes. Apesar da sua importância emergente na saúde pública, ainda pouco se conhece sobre os mecanismos moleculares envolvidos no ciclo replicativo do ZIKV em célula humanas. Assim, o objetivo geral deste estudo foi caracterizar a distribuição subcelular do ZIKV na célula hospedeira e elucidar fatores celulares que regulam o tráfego intracelular de proteínas envolvidos nesses processos. Mais especificamente, determinar os compartimentos celulares que servem de plataforma de m
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Mendes, Rafaela Batista Molás. "Investigação da proteína Anexina A1 em placentas humanas infectadas por Zika vírus /." São José do Rio Preto, 2019. http://hdl.handle.net/11449/182052.

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Orientador: Sonia Maria Oliani<br>Coorientador: Jusciele Brogin Moreli<br>Banca: Estela Maris Andrade Forell Bevilacqua<br>Banca: Flávia Cristina Rodrigues Lisoni<br>Resumo: Introdução: A associação da infecção por Zika vírus (ZIKV) com malformação congênita e sequelas neurológicas trouxe uma preocupação global significativa. Estudos recentes têm mostrado que a infecção viral induz altos níveis de inflamação nas vilosidades placentárias. Neste contexto, a proteína anti-inflamatória anexina 1 (ANXA1) tem sido avaliada especialmente em células de defesa e associada com atividades antiparasitária
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47

Frizzo, Ana Cládia Figueiredo. "Estudo da função auditiva central de crianças com microcefalia por Zika vírus /." Marília, 2019.

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48

Denis, Jessica. "Discrimination sérologique de flavivirus, étude du domaine III de la protéine d’enveloppe du virus Zika comme cible d’anticorps spécifiques. High specificity and sensitivity of Zika EDIII-based ELISA diagnosis highlighted by a large human reference panel. Vector-Borne Transmission of the Zika Virus Asian Genotype in Europe." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS078.

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Le virus Zika fait partie du genre des Flavivirus comme le virus de la dengue. Ils sont transmis par les moustiques du genre Aedes. En 2015, une épidémie a causé plus de 700 000 infections, à l’origine de microcéphalies chez les fœtus et de syndromes de Guillain Barré. Pour la première fois, la transmission d’un arbovirus par voie sexuelle est mise en évidence. Les Flavivirus co-circulent dans de nombreux pays, parfois de façon concomitante. Leurs infections induisent des anticorps capables de reconnaitre différents Flavivirus. Cette réactivité croisée peut conduire, en fonction de leur concen
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Tantaléan, Yépez Derek, José Sánchez-Carbonel, Urizar Gabriela Ulloa, et al. "Arboviruses emerging in Peru: need for early detection of febrile syndrome during El Niño episodes." Elsevier B.V, 2016. http://hdl.handle.net/10757/615645.

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The presence of El Niño Southern Oscillation (ENSO) implies the presence of fluctuating rains in coastal areas and these changes influence the occurrence of febrile syndromes outbreaks. In Peru, Aedes aegypti is the vector responsible for various viruses such as the dengue, Zika, chikungunya, which is distributed in 18 Peruvian departments. These viruses cause similar clinical characteristics in the host and for this reason rapid, sensitive and specific diagnostic tests are needed so that the patient can receive timely treatment.<br>Revisión por pares
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Silveira, Caroline Nunes. "Avaliação da degradação do RNA viral do ZIKA vírus em diferentes compartimentos biológicos." Botucatu, 2019. http://hdl.handle.net/11449/190729.

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Orientador: Rejane Maria Tommasini Grotto<br>Resumo: O vírus Zika pertence a família Flaviviridae, gênero Flavivirus e tem seu genoma viral constituído de uma molécula de RNA de fita simples de polaridade positiva, com aproximadamente 10.700 pb. As interações de Flavivirus com compartimentos biológicos como as plaquetas foram relatadas pela literatura, sendo demostrado que o vírus é carreado para outros tecidos e sua viabilidade é mantida por um maior tempo, no entanto, este tipo de estudo ainda não foi reportado para o ZIKV. O objetivo deste trabalho foi comparar a carga viral do vírus Zika e
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