Academic literature on the topic 'Zhong xing xing gang chang'

Abstract Introduction: Bacillus Calmette-Guérin (BCG) is the standard of care for high-risk non-muscle-invasive bladder cancer (NMIBC) following transurethral resection. However, patients often have heterogeneous responses. Even among those who initially respond well to BCG, 10-20% relapse. Identification of reliable biomarkers predicting the efficacy of BCG remains an unmet need. En bloc resection is a novel technique representing a substantial advancement in the surgical management of NMIBC. We sought to investigate genomic and tumor microenvironmental (TME) profiles in NMIBC and explore potential predictive markers for BCG treatment following en-block resection. Methods: A total of 40 patients with high-risk NMIBC (cTis-T1N0M0) were retrospectively enrolled who underwent en bloc resection followed by BCG instillation. Surgical samples were subjected to NGS sequencing using a 520-gene panel (Burning Rock Biotech, Guangzhou) and multiplex immunofluorescence (mIF) assay. Results: The cohort had a median age of 63 years, and 80% were male. After a median follow-up of 21.8 months, 19/40 patients relapsed with a one-year relapse-free survival (RFS) rate of 57.5%. All tumors were microsatellite stable and showed a median TMB of 7.98muts/Mb. Genomic profiling revealed a high prevalence of alterations in TERT (55%), KDM6A (32.5%), KMT2D (32.5%), FGFR3(30%), PIK3CA (30%), TP53(27.5%), KMT2C (25%), and ARID1A (20%). TME analysis showed higher proportions of M1 macrophages and CD56 dim NK cells in the tumoral compartment and more intense infiltration of CD8+ T cells, exhausted CD8+T, CD56 bright NK cells, and M2 macrophages in the stromal compartment. Multivariate analysis identified TERT C228T mutation (HR=3.28 [95%CI:1.225-8.79], p=0.0181) and alteration in KDM6A (HR=2.94 [95%CI:1.040-8.29], p=0.042) as two independent factors associated with inferior RFS. Patients with concomitant TERT C228T and KDM6A alteration had the shortest RFS (median RFS:5.83months) compared with those who were free of (median RFS: NR) or harbored either one of the two alterations (median RFS:9.13months) (p=0.0022). We also found that tumoral infiltration of CD8+T cells was positively associated with RFS (HR=0.29 [95%CI:0.097-0.885], p=0.0208). Conclusion: The study comprehensively depicted the genomic and TME profiles in NMIBC and identified potential predictive biomarkers for BCG treatment. Our findings may facilitate the stratification of patients and better guide the clinical decision-making on the management of NMIBC. Citation Format: Qi-Dong Xia, Yao-Bing Chen, Jian-Xuan Sun, Chen-Qian Liu, Jin-Zhou Xu, Zhi-Peng Yao, Ye An, Meng-Yao Xu, Si-Han Zhang, Xing-Yu Zhong, Na Zeng, Si-Yang Ma, Hao-Dong He, Heng-Long Hu, Jia Hu, Yi Lu, Lin Shao, Si-Qi Li, Zheng Liu, Shao-Gang Wang. TERT C228T and KDM6A alterations are potential predictive biomarkers in non-muscle-invasive bladder cancer treated with intravesical Bacillus Calmette-Guérin instillation [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2127.

Heavy metals contamination is a serious threat to all life forms. Long term exposure of heavy metals can lead to different life-threatening medical conditions including cancers of different body parts. Phytoremediation and bioremediation offer a potential eco-friendly solution to such problems. Different microbes can interact with heavy metals in a variety of ways such as biotransformation, oxidation/reduction, and biosorption. Phytoremediation of the heavy metals using plants mostly involves rhizofilteration, phytoextraction, phytovolatization, and Phyto stabilization. A synergistic approach using both plants and microbes has proven much more efficient as compared to the individual applications of microbes or plants. This article aims to highlight the synergistic methods used in bioremediation, emphasizing the potent collaboration between bacteria and plants for environmental cleaning, along with the discussion of the importance of site-specific variables and potential constraints. While identifying the necessity for all-encompassing solutions, this review places emphasis on the combination of methodologies as a multifarious rehabilitation approach. This discussion offers insightful suggestions for scholars, scientists and decision-makers about the sustainable recovery of heavy metal-contaminated environments using a comprehensive strategy. REFERENCES Ankit, Bauddh K, Korstad J (2022). Phycoremediation: Use of algae to sequester heavy metals. Hydrobiol. 1(3): 288-303. Arantza SJ, Hiram MR, Erika K, Chávez-Avilés MN, Valiente-Banuet JI, Fierros-Romero G (2022). Bio-and phytoremediation: Plants and microbes to the rescue of heavy metal polluted soils. SN Appl. Sci. 4(2): 59. Azubuike CC, Chikere CB, Okpokwasili GC (2016). Bioremediation techniques–classification based on site of application: principles, advantages, limitations and prospects. World J. Microbiol. Biotechnol. 32: 1-18. Berti WR, Cunningham SD (2000). Phytostabilization of metals. Phytoremediation of toxic metals: Using plants to clean up the environment. Wiley, New York. 71-88. Bingöl NA, Özmal F, Akın B (2017). Phytoremediation and biosorption potential of Lythrum salicaria for nickel removal from aqueous solutions. Pol. J. Environ. Stud. 26(6): 2479-2485. Chandra R, Saxena G, Kumar V (2015). Phytoremediation of environmental pollutants: an eco-sustainable green technology to environmental management, In Advances in biodegradation and bioremediation of industrial waste. 1-29. Chaudhary K, Agarwal S, Khan S (2018). Role of phytochelatins (PCs), metallothioneins (MTs), and heavy metal ATPase (HMA) genes in heavy metal tolerance, In Mycoremediation and Environmental Sustainability. Volume 2: 39-60. Choudhary M, Kumar R, Datta A, Nehra V, Garg N (2017). Bioremediation of heavy metals by microbes, In Bioremediation of salt affected soils: an Indian perspective. 233-255. Chugh M, Kumar L, Shah MP, Bharadvaja N (2022). Algal bioremediation of heavy metals: An insight into removal mechanisms, recovery of by-products, challenges, and future opportunities. Energy Nexus. 7:100129. Congeevaram S, Dhanarani S, Park J, Dexilin M, Thamaraiselvi K (2007). Biosorption of chromium and nickel by heavy metal resistant fungal and bacterial isolates. J. Hazard. Mat. 146(1-2): 270-277. Cristaldi A, Conti GO, Jho EH, Zuccarello P, Grasso A, Copat C, Ferrante M (2017). Phytoremediation of contaminated soils by heavy metals and PAHs. A brief review. Environ. Technol. Inno. 8: 309-326. Crusberg T, Mark S. (2000). Heavy metal remediation of wastewaters by microbial biotraps, In Springer. 123-137. Emenike CU, Jayanthi B, Agamuthu P, Fauziah S (2018). Biotransformation and removal of heavy metals: a review of phytoremediation and microbial remediation assessment on contaminated soil. Environ. Rev. 26(2): 156-168. Ghosh M, Singh S (2005). A review on phytoremediation of heavy metals and utilization of it’s by products. Asian J. Energy Environ. 6(4): 18. Guignardi Z, Schiavon M (2017). Biochemistry of plant selenium uptake and metabolism, In Selenium in plants: molecular, physiological, ecological and evolutionary aspects. 21-34. Hong-Bo S, Li-Ye C, Cheng-Jiang R, Hua L, Dong-Gang G, Wei-Xiang L (2010). Understanding molecular mechanisms for improving phytoremediation of heavy metal-contaminated soils. Crit. Rev. Biotechnol. 30(1): 23-30. Igiri BE, Okoduwa SI, Idoko GO, Akabuogu EP, Adeyi AO, Ejiogu IK (2018). Toxicity and bioremediation of heavy metals contaminated ecosystem from tannery wastewater: a review. J. Toxicol. 2018. Jabeen R, Ahmad A, Iqbal M (2009). Phytoremediation of heavy metals: physiological and molecular mechanisms. Bot. Rev. 75: 339-364. Joshi P, Swarup A, Maheshwari S, Kumar R, Singh N (2011). Bioremediation of heavy metals in liquid media through fungi isolated from contaminated sources. Indian J. Microbiol. 51: 482-487. Junaid M, Hashmi MZ, Tang YM, Malik RN, Pei,DS (2017). Potential health risk of heavy metals in the leather manufacturing industries in Sialkot, Pakistan. Sci. Rep. 7(1): 8848. Kapahi M, Sachdeva S (2019). Bioremediation options for heavy metal pollution. J. Health Pollut. 9(24): 191203. Lebeau T, Jézéquel K, Braud A (2011). Bioaugmentation-assisted phytoextraction applied to metal-contaminated soils: state of the art and future prospects, In Microbes and Microbial Technology: Agricultural and Environmental Applications. 229-266. Leong YK, Chang JS (2020). Bioremediation of heavy metals using microalgae: Recent advances and mechanisms. Bioresour.Technol. 303: 122886. Limmer M, Burken J (2016). Phytovolatilization of organic contaminants. Environ. Sci. Technol. 50(13): 6632-6643. Ma Y, Oliveira RS, Freitas H, Zhang C (2016). Biochemical and molecular mechanisms of plant-microbe-metal interactions: relevance for phytoremediation. Front. Plant Sci. 7: 918. Manzoor M, Gul I, Ahmed I, Zeeshan M, Hashmi I, Amin BAZ, Kallerhoff J, Arshad M (2019). Metal tolerant bacteria enhanced phytoextraction of lead by two accumulator ornamental species. Chemosphere. 227: 561-569. Mueller B, Rock S, Gowswami D, Ensley D (1999). Phytoremediation decision tree. Prepared by-Interstate Technology and Regulatory Cooperation Work Group. 1-36. Nies DH (1999). Microbial heavy-metal resistance. Appl. Microbiol. Biotechnol. 51: 730-750. Nies DH, Silver S (1995). Ion efflux systems involved in bacterial metal resistances. J. Ind. 14: 186-199. Pande V, Pandey SC, Sati D, Bhatt P, Samant M (2022). Microbial interventions in bioremediation of heavy metal contaminants in agroecosystem. Front. Microbiol. 13: 824084. Pandey VC, Bajpai O (2019). Phytoremediation: from theory toward practice, In Phytomanagement of polluted sites. 1-49. Robinson BH, Leblanc M, Petit D, Brooks RR, Kirkman JH, Gregg PE (1998). The potential of Thlaspi caerulescens for phytoremediation of contaminated soils. Plant Soil. 203: 47-56. Romantschuk M, Lahti-Leikas K, Kontro M, Allen JA, Sinkkonen A (2023). Bioremediation of contaminated soil and groundwater by in situ Front. Microbiol. 14: 1258148. Sabreena, Hassan S, Bhat SA, Kumar V, Ganai BA, Ameen F (2022). Phytoremediation of heavy metals: An indispensable contrivance in green remediation technology. Plants. 11(9): 1255. Saha L, Tiwari J, Bauddh K, Ma Y (2021). Recent developments in microbe–plant-based bioremediation for tackling heavy metal-polluted soils. Front. Microbiol. 12: 731723. Sharma I. (2020). Bioremediation techniques for polluted environment: concept, advantages, limitations, and prospects, In Trace metals in the environment-new approaches and recent advances. IntechOpen. Sharma JK, Kumar N, Singh NP, Santal, AR (2023). Phytoremediation technologies and their mechanism for removal of heavy metal from contaminated soil: An approach for a sustainable environment. Front. Plant Sci. 14: 1076876. Shen X, Dai M, Yang J, Sun L, Tan X, Peng C, Ali I, and Naz I (2022). A critical review on the phytoremediation of heavy metals from environment: Performance and challenges. Chemosphere. 291: 132979. Silver S (2011). BioMetals: a historical and personal perspective. Biometals. 24(3): 379-390. Silver S, Phung LT (2005). A bacterial view of the periodic table: genes and proteins for toxic inorganic ions. J. Ind. Microbiol. Biotechnol. 32: 587-605. Singh N, Santal AR (2015). Phytoremediation of heavy metals: the use of green approaches to clean the environment, In Phytoremediation: Management of Environmental Contaminants. Volume 2: 115-129. Strong PJ, Burgess JE (2008). Treatment methods for wine-related and distillery wastewaters: a review. Bioremediation J. 12(2): 70-87. Syranidou E, Christofilopoulos S, Gkavrou G, Thijs S, Weyens N, Vangronsveld J, Kalogerakis N (2016). Exploitation of endophytic bacteria to enhance the phytoremediation potential of the wetland helophyte Juncus acutus. Front. Microbiol. 7: 1016. Umrania VV (2006). Bioremediation of toxic heavy metals using acidothermophilic autotrophes. Bioresour. Technol. 97(10): 1237-1242. Valls M, De Lorenzo V (2002). Exploiting the genetic and biochemical capacities of bacteria for the remediation of heavy metal pollution. FEMS Microbiol. Rev. 26(4): 327-338. Verma P, George K, Singh H, Singh S, Juwarkar A, Singh R (2006). Modeling rhizofiltration: heavy-metal uptake by plant roots. Environ. Model. Assess. 11: 387-394. Wu Y, Li Z, Yang Y, Purchase D, Lu Y, Dai Z (2021). Extracellular polymeric substances facilitate the adsorption and migration of Cu2+ and Cd2+ in saturated porous media. Biomolecules. 11(11): 1715. Wuana RA, Okieimen FE (2011). Heavy metals in contaminated soils: a review of sources, chemistry, risks and best available strategies for remediation. International Scholarly Research Notices. Yan A, Wang Y, Tan SN, Mohd Yusof ML, Ghosh S, Chen Z (2020). Phytoremediation: a promising approach for revegetation of heavy metal-polluted land. Front. Plant Sci. 11: 359. Zhang Y, Hu J, Bai J, Wang J, Yin R, Wang J, and Lin X (2018). Arbuscular mycorrhizal fungi alleviate the heavy metal toxicity on sunflower (Helianthus annuus) plants cultivated on a heavily contaminated field soil at a WEEE-recycling site. Sci. Total Environ. 628: 282-290.

Graphene-based composites have received a great deal of attention in recent year because the presence of graphene can enhance the conductivity, strength of bulk materials and help create composites with superior qualities. Moreover, the incorporation of metal oxide nanoparticles such as Fe3O4 can improve the catalytic efficiency of composite material. In this work, we have synthesized a composite material with the combination of reduced graphene oxide (rGO), and Fe3O4 modified tissue-paper (mGO-PP) via a simple hydrothermal method, which improved the removal efficiency of the of methylene blue (MB) in water. MB blue is used as the model of contaminant to evaluate the catalytic efficiency of synthesized material by using a Fenton-like reaction. The obtained materials were characterized by SEM, XRD. The removal of materials with methylene blue is investigated by UV-VIS spectroscopy, and the result shows that mGO-PP composite is the potential composite for the color removed which has the removal efficiency reaching 65% in acetate buffer pH = 3 with the optimal time is 7 h. Keywords Graphene-based composite, methylene blue, Fenton-like reaction. References [1] Ma Joshi, Rue Bansal, Reng Purwar, Colour removal from textile effluents, Indian Journal of Fibre & Textile Research, 29 (2004) 239-259 http://nopr.niscair.res.in/handle/123456789/24631.[2] Kannan Nagar, Sundaram Mariappan, Kinetics and mechanism of removal of methylene blue by adsorption on various carbons-a comparative study, Dyes and pigments, 51 (2001) 25-40 https://doi.org/10.1016/S0143-7208(01)00056-0.[3] K Rastogi, J. N Sahu, B. C Meikap, M. N Biswas, Removal of methylene blue from wastewater using fly ash as an adsorbent by hydrocyclone, Journal of hazardous materials, 158 (2008) 531-540.https://doi.org/10.1016/j.jhazmat.2008.01. 105.[4] Qin Qingdong, Ma Jun, Liu Ke, Adsorption of anionic dyes on ammonium-functionalized MCM-41, Journal of Hazardous Materials, 162 (2009) 133-139 https://doi.org/10.1016/j.jhazmat. 2008.05.016.[5] Mui Muruganandham, Rps Suri, Sh Jafari, Mao Sillanpää, Lee Gang-Juan, Jaj Wu, Muo Swaminathan, Recent developments in homogeneous advanced oxidation processes for water and wastewater treatment, International Journal of Photoenergy, 2014 (2014). http://dx. doi.org/10.1155/2014/821674.[6] Herney Ramirez, Vicente Miguel , Madeira Luis Heterogeneous photo-Fenton oxidation with pillared clay-based catalysts for wastewater treatment: a review, Applied Catalysis B: Environmental, 98 (2010) 10-26 https://doi.org/ 10.1016/j.apcatb.2010.05.004.[7] Guo Rong, Jiao Tifeng, Li Ruifei, Chen Yan, Guo Wanchun, Zhang Lexin, Zhou Jingxin, Zhang Qingrui, Peng Qiuming, Sandwiched Fe3O4/carboxylate graphene oxide nanostructures constructed by layer-by-layer assembly for highly efficient and magnetically recyclable dye removal, ACS Sustainable Chemistry & Engineering, 6 (2017) 1279-1288 https://doi.org/10.1021/acssuschemeng.7b03635.[8] Sun Chao, Yang Sheng-Tao, Gao Zhenjie, Yang Shengnan, Yilihamu Ailimire, Ma Qiang, Zhao Ru-Song, Xue Fumin, Fe3O4/TiO2/reduced graphene oxide composites as highly efficient Fenton-like catalyst for the decoloration of methylene blue, Materials Chemistry and Physics, 223 (2019) 751-757 https://doi.org/ 10.1016/j.matchemphys.2018.11.056.[9] Guo Hui, Ma Xinfeng, Wang Chubei, Zhou Jianwei, Huang Jianxin, Wang Zijin, Sulfhydryl-Functionalized Reduced Graphene Oxide and Adsorption of Methylene Blue, Environmental Engineering Science, 36 (2019) 81-89 https://doi. org/10.1089/ees.2018.0157.[10] Zhao Lianqin, Yang Sheng-Tao, Feng Shicheng, Ma Qiang, Peng Xiaoling, Wu Deyi, Preparation and application of carboxylated graphene oxide sponge in dye removal, International journal of environmental research and public health, 14 (2017) 1301 https://doi.org/10.3390/ijerph14111301.[11] Yu Dandan, Wang Hua, Yang Jie, Niu Zhiqiang, Lu Huiting, Yang Yun, Cheng Liwei, Guo Lin, Dye wastewater cleanup by graphene composite paper for tailorable supercapacitors, ACS applied materials & interfaces, 9 (2017) 21298-21306 https://doi.org/10.1021/acsami.7b05318.[12] Wang Hou, Yuan Xingzhong, Wu Yan, Huang Huajun, Peng Xin, Zeng Guangming, Zhong Hua, Liang Jie, Ren MiaoMiao, Graphene-based materials: fabrication, characterization and application for the decontamination of wastewater and wastegas and hydrogen storage/generation, Advances in Colloid and Interface Science, 195 (2013) 19-40 https://doi. org/10.1016/j.cis.2013.03.009.[13] Marcano Daniela C, Kosynkin Dmitry V, Berlin Jacob M, Sinitskii Alexander, Sun Zhengzong, Slesarev Alexander, Alemany Lawrence B, Lu Wei, Tour James M, Improved synthesis of graphene oxide, ACS nano, 4 (2010) 4806-4814 https://doi.org/10.1021/nn1006368.[14] Zhang Jiali, Yang Haijun, Shen Guangxia, Cheng Ping, Zhang Jingyan, Guo Shouwu, Reduction of graphene oxide via L-ascorbic acid, Chemical Communications, 46 (2010) 1112-1114 http://doi. org/10.1039/B917705A [15] Gong Ming, Zhou Wu, Tsai Mon-Che, Zhou Jigang, Guan Mingyun, Lin Meng-Chang, Zhang Bo, Hu Yongfeng, Wang Di-Yan, Yang Jiang, Nanoscale nickel oxide/nickel heterostructures for active hydrogen evolution electrocatalysis, Nature communications, 5 (2014) 4695 https:// doi.org/10.1038/ncomms5695.[16] Wu Zhong-Shuai, Yang Shubin, Sun Yi, Parvez Khaled, Feng Xinliang, Müllen Klaus, 3D nitrogen-doped graphene aerogel-supported Fe3O4 nanoparticles as efficient electrocatalysts for the oxygen reduction reaction, Journal of the American Chemical Society, 134 (2012) 9082-9085 https://doi.org/10.1021/ja3030565.[17] Nguyen Son Truong, Nguyen Hoa Tien, Rinaldi Ali, Nguyen Nam Van, Fan Zeng, Duong Hai Minh, Morphology control and thermal stability of binderless-graphene aerogels from graphite for energy storage applications, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 414 (2012) 352-358 https://doi.org/ 10.1016/j.colsurfa.2012.08.048.[18] Deng Yang, Englehardt James D, Treatment of landfill leachate by the Fenton process, Water research, 40 (2006) 3683-3694 https://doi.org/ 10.1016/j.watres.2006.08.009.

A doença mão-pé-boca é uma infecção viral, normalmente benigna que afeta comumente crianças até 10 anos, causada pelos enterovírus humano. O propósito deste estudo foi revisar os aspectos da doença que se faz presente nos dias atuais abordando a etiologia, epidemiologia, surtos, sintomatologia e comorbidades, diagnóstico, prevenção e tratamento. Foram selecionadas publicações em periódicos referenciados nas fontes de dados do Google Acadêmico, Pubmed e Periódicos Capes com as palavras chaves relacionadas ao tema desse trabalho como doença mão-pé-boca e crianças, sendo selecionados artigos produzidos até 2017. Apesar de diagnóstico clínico aparentemente simples, a doença pode ser confundida com outras enfermidades por suas características semelhantes, que podem induzir o colega odontólogo ao equívoco de diagnóstico.Descritores: Doença de Mão, Pé e Boca; Diagnóstico, Odontopediatria.ReferênciasSarkar PK, Sarker NK, Tayab A. Hand, foot and mouth disease (hfmd):an update. 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Br Med J. 1960;2(5214):1708–11.Cristovam MAS, Osaku NO, Gabriel GFCP, Rodrigues SPSG, Pompeu CB, Pires TG. Síndrome mão-pé-boca: relato de caso. Rev Med Res. 2014;16(1):42-5.Repass GL, Palmer WC, Stancampiano FF. Hand, foot, and mouth disease: identifying and managing na acute viral syndrome. Cleve Clin J Med. 2014;81(9):537-43.Kashyap RR, Kashyap RS. Hand, foot and mouth disease- a short case report. J Clin Exp Dent. 2015;7(2):e336-38.Babu NA, Malathi L, Kasthuri M, Jimson S. Ulcerative lesions of the oral cavity - an overview. Biomed Pharmacol J. 2017;10(1):401-5.Xing W, Liao Z, Sun J, Wu J T, Chang Z, Liu F, et al. Hand, foot, and mouth disease in China, 2008–12: an epidemiological study. Lancet Infect Dis. 2014;14:308-18.Wu Y, Yeo A, Phoon MC, Tan EL, Poh CL, QuakSH et al. The largest outbreak of hand; foot and mouth disease in Singapore in 2008: the role of enterovirus 71 and coxsackievirus A strains. 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碩士
東吳大學
中國文學系
105
Xia Lun（1680-1753 later）, courtesy name as Yan-si（言絲）, pseudonym as Xing-zhai（惺齋）, and old age pseudonym as Qu-sou（臞叟）, Zhejiang Qiantang （now Hangzhou）people. In an early age, he could not obtain official positions. Although he became an official after forty years old, he was still unable to bring his ambition into full play. In the first year of Qianlong（1736）, he wanted to take Bo Xue Hong Ci（博學鴻詞）, but being obstructed（阻攔） by someone. After that, he never attended another imperial examination. In the later years, he created dramas to amuse himself. And his dramas have Wu- Xia- Bi（《無瑕璧》）, Xing- Hua- Cun（《杏花村》）, Rui- Yun- Tu（《瑞筠圖》）, Guang- Han- Ti（《廣寒梯》）, Nan- Yang- Le（《南陽樂》）and Hua- E- Yin（《花萼吟》）, which are collectively known as The Six New Dramas（《新曲六種》）. 　　About the story of dramas, it encompasses ‘loyalty’, ‘filial’, ‘piety’, ‘justice’ as the core of ideas. For the content of the play, through Wu- Xia- Bi shows the meaning of the monarch and his ministers, Xing- Hua- Cun shows the meaning of the father and son, Rui- Yun- Tu shows the meaning of the couple, Guang- Han- Ti shows the meaning of friendship, Hua- E- Yin shows the meaning of brothers, and through Nan- Yang- Le makes up history of the regret. Among six dramas is the ‘persuasion’ as the core, extending the ‘karma’ function, and to remind people that there is a cycle in the world, it can’t be lucky attitude to face their own behavior. The concept makes The Six New Dramas as a warning in general, and still convey the world truth. 　　In addition to the theme and spirit of the drama, pai - chang（排場）in Xia Lun’ s drama is another research-oriented. According to quantified the way, this report shows pai - chang’s situation of six dramas, constructing the literary and artistic value, phenomenon and regularity of Xing Zhai’s play. 　　This report is divided into eight chapters. The first chapter is about the discourse and theory of the predecessors, to establish the structure of the pai- chang’s theory. The second chapter to the seventh chapter is about the pai- chang’s analysis of six dramas, and every chapter is divided into ‘Guan- Mu- Qing- Jie’（關目情節）, ‘Leng-Re-Xiang-Ji’（冷熱相濟）and ‘Lao-Yi-Jun-Heng’（勞逸均衡） three sections, from which analysis of pai- chang’s situation. The eighth chapter is compare of six dramas, which is also divided into ‘Leng-Re-Xiang-Ji’ and ‘Lao-Yi-Jun-Heng’ two sections, by chart to explore problem and the law of pai- chang.