Dissertations / Theses on the topic 'Zebrafish models'
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Goldsmith, P. "Zebrafish models of retinal degeneration." Thesis, University of Cambridge, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599478.
Full textSmith, Laura Lindsay. "Zebrafish Models of Congenital Myopathy." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:23845448.
Full textMedical Sciences
Pressley, Meagan E. "Infectious Disease Models for the Zebrafish." Fogler Library, University of Maine, 2004. http://www.library.umaine.edu/theses/pdf/PressleyME2004.pdf.
Full textSimms, Roslyn Jane. "Zebrafish models of cystic kidney disease related ciliopathies." Thesis, University of Newcastle upon Tyne, 2013. http://hdl.handle.net/10443/2473.
Full textNovorol, Claire. "Microcephaly models in the developing zebrafish retinal neuroepithelium." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648860.
Full textDaggett, Jenny. "Evaluation and characterisation of two zebrafish models of schizophrenia." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/9603.
Full textGanis, Jared Jason. "Regulators of hemoglobin switching in zebrafish and human models." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11391.
Full textAlbacker, Colleen Elizabeth. "Chromatin-Modifying Factors in Zebrafish Models of Rhabdomyosarcoma and Hematopoiesis." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10098.
Full textDong, Bo. "High-throughput image analysis of zebrafish models of Parkinson's disease." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/18090/.
Full textMetzner, Aylin. "A study of ADPKD pathogenesis and treatment in zebrafish models." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/16020/.
Full textPrecazzini, Francesca. "Zebrafish models of uveal and cutaneous melanoma for preclinical studies." Doctoral thesis, Università degli studi di Trento, 2019. http://hdl.handle.net/11572/245749.
Full textLyon, Alison Nicole. "Generation and Analysis of Motor Neuron Disease Models in Zebrafish." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337276861.
Full textToms, Maria. "Investigating the pathophysiology of KCNJ13 and USH2A retinopathies using zebrafish models." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10053968/.
Full textReimers, Mark J. "Ethanol-dependent developmental toxicity in zebrafish /." Connect to full text via ProQuest. IP filtered, 2005.
Find full textZaksauskaite, Ringaile. "Analysis of chromosomal protein-linked break repair in zebrafish and mammalian models." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/20765/.
Full textNicolas, Hannah Almira. "Understanding Molecular Mechanisms of Striated Muscle Laminopathies Using Cellular and Zebrafish Models." Thesis, Université d'Ottawa / University of Ottawa, 2020. http://hdl.handle.net/10393/41008.
Full textToulis, Vasileios. "Zebrafish and mouse models for studying deubiquitinating enzyme genes as candidates for retinal dystrophies." Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/674031.
Full textHulbig, Veronica A. "Developing a Model for Bacterial Kidney Disease in the Zebrafish, Danio rerio." Fogler Library, University of Maine, 2010. http://www.library.umaine.edu/theses/pdf/HulbigVA2010.pdf.
Full textTian, Li, and 田理. "Toxicological effects and mechanisms of selected foodborne toxins in medaka and zebrafish models." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/197111.
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Biological Sciences
Doctoral
Doctor of Philosophy
Chhabria, Karishma. "Development of zebrafish and computational models of neurovascular coupling in health and disease." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/22833/.
Full textRounding, Natalie. "Zebrafish C9orf72 loss-of-function models of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/19832/.
Full textBalow, Stephanie Ann. "Investigation of CHD7 Function in Developmental Models of CHARGE Syndrome." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1396625345.
Full textTekeli, Işil. "Bioengineering approach to study the role of cell migration during zebrafish heart regneration." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/396098.
Full textLos humanos tienen una capacidad muy limitada para regenerar el corazón y, como consecuencia de ello, una de cada tres personas fallece debido a enfermedades cardíacas. En cambio, el pez cebra tiene una enorme capacidad intrínseca para restaurar grandes porciones de su corazón tras un daño, por lo que se ha convertido en uno de los modelos experimentales más usados para investigar la regeneración del corazón. Entender los mecanismos que controlan la regeneración cardíaca del pez cebra permitirá desarrollar estrategias para regenerar el corazón humano y buscar soluciones a estas enfermedades. Basándonos en este gran objetivo, el trabajo que forma el estudio de esta tesis doctoral detalla algunas aproximaciones de bioingeniería dirigidas a estudiar el papel de la migración celular de los cardiomiocitos y de las células del epicardio durante la regeneración del corazón del pez cebra. La primera aproximación es un sistema de seguimiento del linaje de los cardiomiocitos del pez cebra para investigar su destino durante la regeneración cardiaca. Para esto, se desarrolló un sistema de marcado genético de linaje con triple especificidad, de tipo celular, temporal y espacial, que permitió marcar los cardiomiocitos en diferentes partes del corazón. Utilizando esta técnica se demostró que durante la regeneración sólo los cardiomiocitos inmediatamente adyacentes a la lesión contribuyen al miocardio regenerado. A continuación, se utilizó la iluminación multifotón de tres fotones para fotoactivar cardiomiocitos in vivo con el objetivo de aumentar la resolución espacial del marcado genético. En este trabajo se demostró teóricamente y experimentalmente que la iluminación de tres-fotones supera problemas de dispersión y es capaz de realizar la fotoactivación, convirtiéndose en el primer ejemplo donde se consigue utilizar este tipo de iluminación para fotoactivar células in vivo. El uso de la iluminación de tres fotones en combinación con el sistema de marcado genético fotoinducible permitió marcar los cardiomiocitos de embriones de pez cebra de forma prospectiva. Por último, se desarrolló un sistema ex vivo para caracterizar el comportamiento migratorio de las células del epicardio del corazón del pez cebra con el fin de investigar las características físicas de la migración celular durante la regeneración. Este método permitió medir las características físicas esenciales para la migración celular, tales como la velocidad migratoria y las fuerzas de tracción en las células del epicardio.
Pimentel, Angela Bairos. "Algorithm for the Parkinson’s disease behavioural models characterization using a biosensor." Master's thesis, Faculdade de Ciências e Tecnologia, 2012. http://hdl.handle.net/10362/8443.
Full textThe neurodegenerative disease, Parkinson’s Disease (PD) constitutes a major health problem in the modern world, and its impact on public health and society is expected to increase with the ongoing ageing of the human population. This disease is characterized by motor and non-motor manifestations that are progressive and ultimately refractory to therapeutic interventions. The degeneration of dopaminergic neurons emanating from the substantia nigra is largely responsible for the motor manifestations. Thus, understanding the behaviour related to this disease is an added value for the diagnosis and treatment of PD. Also, in vivo models are essential tools for deciphering the molecular mechanisms underpinning the neurodegenerative process. Zebrafish has several features that make this species a good candidate to study PD. In particular, the occurrence of behavioural phenotypes of treated animals with neurotoxin drugs that mimic the disease has been investigated. And, an electric biosensor, Marine On-line Biomonitor System (MOBS) is being used for the real-time quantification of such behaviour. This equipment allows quantifying the fish movements through signal processing algorithms. Specifically, the algorithm is used for the evaluation of fish locomotion detected by a series of bursts in the domain of MOBS that correspond to the zebrafish tail-flip activity. In this thesis we proceeded to the development of an algorithm affording a electrical signal discrimination between "healthy" and "ill" zebrafish and consequently improving the detection of parkinsonism-like phenotypes in zebrafish. The first approach was the improvement of the existent algorithm. However, the first analysis failed to distinguish between different behavioural phenotypes when fish were treated with the neurotoxin 6-hydroxydopamine (6-OHDA). Consequently, we generated a new algorithm based on Machine Learning techniques. As a result, the novel algorithm provided a classification over the health condition of the fish, if the same is "healthy" or "ill" with its respective probability and the level of activity of the fish in number of tail-flips per minute. The method Support Vector Machine (SVM)was useful for the classification of the fish events. The zero crossing rate parameter was used for the characterization of the swimming activities. The algorithm was also integrated in the platform Open Signals, and for a faster evaluation of the signals, the algorithm implementation included parallel programming methods. This algorithm is a useful tool to study behaviour in zebrafish. Not only it will allow a more realistic study over the PD research area but also test and assess new drugs that use zebrafish as animal model.
Green, Jon Marc. "Development of novel transgenic zebrafish models and their application to studies on environmental oestrogens." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/27141.
Full textÖrn, Stefan. "The zebrafish as a model organism for evaluation of endocrine disrupters /." Uppsala : Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200628.pdf.
Full textWojciechowska, Sonia. "The conditional control of MITF reveals cellular subpopulations essential for melanoma survival and recurrence in new zebrafish models." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/29645.
Full textIvarsson, Adam. "Expediting Gathering and Labeling of Data from Zebrafish Models of Tumor Progression and Metastasis Using Bespoke Software." Thesis, Linköpings universitet, Institutionen för datavetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-148691.
Full textVishnolia, Krishan Kumar. "Development and charaterisation of 3 dimensional culture models for zebrafish (Danio rerio) skeletal muscle cells." Thesis, University of Bedfordshire, 2013. http://hdl.handle.net/10547/556396.
Full textYu, Xinge. "Stroke Study: Novel Animal Models and Innovative Treatment Strategy." Ohio University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1450735023.
Full textMartin, Brit Leigh Martin. "Toward the use of whole, live developing zebrafish as models for skeletal and cardiac muscle contraction." The Ohio State University, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=osu1500611447591388.
Full textAvdesh, Avdesh. "Pharmacological modulation of learning and memory in mice and zebrafish: Implications for Alzheimer’s disease animal models." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2013. https://ro.ecu.edu.au/theses/570.
Full textTang, Fan. "Protective effects of a novel derivative from danshensu tetramethylpyrazine on doxorubicin-induced cardiotoxicity in H9c2 and zebrafish models." Thesis, University of Macau, 2018. http://umaclib3.umac.mo/record=b3952166.
Full textFenero, Camila Ideli Morales. "Estudo do modelo de inflamação intestinal induzida por TNBS em larvas de Zebrafish (Danio rerio)." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-09122015-123622/.
Full textInflammatory bowel diseases are characterized by a dysregulation in immune response against microbiota. The zebrafish has emerged as a new model for the study of inflammatory diseases. Short chain fatty acids (SCFAs) are products of the intestinal microflora, which have anti-inflammatory roles and appear as a possible therapy against inflammatory diseases. The implementation of intestinal inflammation model induced by trinitrobencenesulfonic acid (TNBS) in zebrafish larvae, increased mortality in a dose-dependent manner. Was observe dilatation lumen and straightening of the intestinal villi. No changes were detected in the production of mucus or in the number of goblet cells but had a slight increase in apoptosis and decreased proliferation in exposed to TNBS. Also has, increased cytokines and infiltrating myeloid cells, and dysbiosis of the microbiota. Treatment with SCFAs generate high mortality above 10 mM concentrations, but there anti-inflammatory action to this same concentration.
Akande, Motunrayo Ganiyat. "The toxicological evaluation of sewage effluents and pharmaceuticals with the use of zebrafish as a model organism /." Uppsala : Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2008. http://epsilon.slu.se/10691471.pdf.
Full textKnapp, Silvana Maria [Verfasser], and F. le [Akademischer Betreuer] Noble. "Esm1 modulates spinal cord vascularization in Vegfaa gain-of-function zebrafish models / Silvana Maria Knapp ; Betreuer: F. le Noble." Karlsruhe : KIT-Bibliothek, 2020. http://d-nb.info/1206646616/34.
Full textHewamadduma, Channa. "Investigation of the role of TDP-43 in amyotrophic lateral sclerosis (ALS) using patient derived fibroblasts and zebrafish as models." Thesis, University of Sheffield, 2014. http://etheses.whiterose.ac.uk/7134/.
Full textSolchenberger, Barbara [Verfasser], and Christian [Akademischer Betreuer] Haass. "Generation of granulin knock out zebrafish models for frontotemporal lobar degeneration and related disorders by genome editing / Barbara Solchenberger. Betreuer: Christian Haass." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1080663258/34.
Full textKneipp, Moritz [Verfasser], Daniel [Akademischer Betreuer] Razansky, Gil [Gutachter] Westmeyer, Vasilis [Gutachter] Ntziachristos, and Arthur [Gutachter] Konnerth. "Rapid Functional Optoacoustic Imaging of Brain Activity in Murine and Zebrafish Models / Moritz Kneipp ; Gutachter: Gil Westmeyer, Vasilis Ntziachristos, Arthur Konnerth ; Betreuer: Daniel Razansky." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1140835076/34.
Full textBourefis, Annis-Rayan. "Novel FUS and CHCHD10 models to investigate pathogenic mechanisms in Amyotrophic Lateral Sclerosis." Thesis, Sorbonne université, 2019. http://www.theses.fr/2019SORUS177.
Full textAmyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder caused by progressive degeneration of upper and lower motor neurons (MNs), with a very rapid clinical course. It leads to muscle weakness and atrophy progressing to paralysis, with respiratory failure being the major cause of death within years following clinical diagnosis. Two major genes mutated in ALS patients are the RNA-binding protein FUS (FUSed in sarcoma), implicated in RNA metabolism, and coiled-coil-helix-coiled-coil-helix domain 10 (CHCHD10), which plays a role in mitochondria stability. Both these genes have been investigated through different model systems, from small invertebrate models to patient biopsies. However, the major phenotypic features obtained in these models are complex and often controversial. The objective of this work is to provide new insights on the implication of these genes in ALS through the use of new models.To investigate the pathogenic mechanisms induced by FUS and CHCHD10, we generated and characterized two novel stable non-sense mutant zebrafish models for the orthologues of these genes and highlighted several ALS phenotypic features. We demonstrated, for the FUS model but not for CHCHD10, reduced lifespan, locomotor disabilities, aberrant motor axons, disorganized neuromuscular junction (NMJ), muscle and mitochondrial alteration, as well as molecular changes. These findings indicate that loss of fus expression is responsible for the occurrence of distal pathological signs at the NMJ, thus supporting a “dying-back” neuronopathy, in which early disease hallmarks start at the level of the NMJ and progress towards MN cell bodies
Söllner, Rosemarie Waltraud [Verfasser], Wolfgang [Akademischer Betreuer] Wurst, and Thomas [Akademischer Betreuer] Misgeld. "Establishment and cell biological analysis of neurodegeneration models in zebrafish based on Parkinson’s disease-linked genes LRRK2 and PINK1 / Rosemarie Waltraud Söllner. Gutachter: Wolfgang Wurst ; Thomas Misgeld. Betreuer: Wolfgang Wurst." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1072758024/34.
Full textHejmanowski, Ashley Q. "Allelic and genetic heterogeneity of two common genetic diseases." The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1095309751.
Full textLeventea, Eleni. "Zebrafish as model for human ciliopathies." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/15413/.
Full textKarttunen, Marja Johanna. "Zebrafish model of demyelination and remyelination." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/25702.
Full textRose, Kristin. "A Zebrafish Model of Uveal Melanoma." Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467345.
Full textMedical Sciences
Costa, Marc Michael John Da. "A zebrafish model of motor neurone disease." Thesis, University of Sheffield, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548470.
Full textBuckley, C. E. "Zebrafish : a transparent screening model of myelination." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597064.
Full textKishida, Marcia Gruppi. "Investigating non-canonical vertebral development in the zebrafish model system." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/276830.
Full textSullivan, Matthew J. "The Zebrafish as a Model for Cystic Fibrosis." Fogler Library, University of Maine, 2008. http://www.library.umaine.edu/theses/pdf/SullivanMJ2008.pdf.
Full textRaghupathy, Rakesh Kotapati. "Zebrafish as a model for Leber Congenital Amaurosis." Thesis, Glasgow Caledonian University, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.700985.
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