Academic literature on the topic 'Yi hai gong si'

Este trabajo se centra en la validación de la escala propuesta por Yi y Gong (2013) para medir el comportamiento de co-creación de valor desde la perspectiva del cliente. En el proceso de validación se siguen las recomendaciones de Camisón y Bou (2000). Para ello, se analiza la fiabilidad y validez del instrumento de medida, utilizando una muestra compuesta por 374 usuarios de servicios relacionados con el cuidado personal. Los resultados confirman la multidimensionalidad de la escala para el contexto español, si bien muestran la existencia de cinco dimensiones y quince ítems, frente a los veintinueve ítems y ocho dimensiones de la escala original. Las principales contribuciones se derivan del desarrollo de la escala, toda vez que la aceptación de la misma requiere demostrar su estabilidad en diferentes entornos y situaciones. Con respecto a las implicaciones para la gestión, el estudio contribuye a facilitar la medición del grado de participación activa de los clientes en la entrega y prestación del servicio, cuestión esta que se considera de gran importancia para incrementar la implicación, el compromiso y la lealtad del cliente hacia la organización.

Abstract Immune checkpoint inhibitors (ICIs) have been widely used in recurrent or metastatic nasopharyngeal carcinoma (NPC), but the addition of ICIs to chemoradiotherapy in locoregionally advanced (LA) NPC requires further investigation. We conducted a phase II, single-arm trial to evaluate the efficacy and safety of neoadjuvant gemcitabine, cisplatin (GP) plus tislelizumab followed by concurrent chemoradiotherapy (CCRT) in LA-NPC. All participants received 3 cycles of GP chemotherapy plus tislelizumab (200 mg) followed by 3 cycles of cisplatin-based CCRT. The primary endpoint was the clinical complete response rate (CR) after neoadjuvant chemoimmunotherapy (NAT). The secondary endpoints include pathological CR rate, progression-free survival (PFS), overall survival (OS), locoregional relapse-free survival (LRRFS), distant metastasis-free survival (DMFS), etc. Pretreatment blood samples and paired (pre-/post-NAT) tissue biopsies were collected to perform full-spectrum peripheral T-cell profiling, PD-L1 and tertiary lymphoid structures (TLS) staining. Among all 63 participants, the CR rate after NAT reached 41.3% (95% CI, 28.8%-53.8%), far exceeding our hypothesized CR rate of 22%. The objective response rate (ORR) and pCR rate after NAT were 88.9% (95% CI, 80.9% to 96.9%) and 74.6% (95% CI, 62.1% to 84.7%), respectively. As of July 15th, 2023, after the median follow-up of 25 months, the 2-year PFS and OS were 98.4% and 100%. The incidence of grade 3-4 immunotherapy-related adverse events was 1.6%. The compliance of CCRT was not compromised. Patients who achieved CR had significantly more circulating CD4+ and CD8+ effector memory T cells (Tem), regulatory T cells (Treg) and follicular helper T cells (Tfh). The peripheral abundance of LAG3+ Tem and Tfh were independently predictive of NAT response. The number and maturation of TLS significantly increased after NAT in the CR group, but not in the Non-CR group. GP chemotherapy plus tislelizumab followed by CCRT was highly therapeutic and safe in treating LA-NPC, further randomized phase III studies are awaited. Citation Format: Xiao-Yun Li, Si-Yi Xie, Qiu-Yan Chen, Hai-Qiang Mai, Lin-Quan Tang. A phase II trial of neoadjuvant gemcitabine, cisplatin plus tislelizumab followed by concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: Clinical efficacy, safety and the biomarker analysis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4025.

LANGUAGE NOTE | Document text in Chinese; abstract also in English. 司馬遷《史記•孔子世家》記載了古代《詩經》有詩三千餘篇，孔子去其重復，為三百零五篇。歷代學者對此有贊成的，也有反對的，到現在還未成定讞，成為了兩千多年來的學術公案。本文嘗試從孔子自己説的「放鄭聲」、「鄭聲淫」這個標準來看孔子删詩説的可靠性。文中首先提出古代聲（樂）、詩不分的現象，這在《荀子》、《墨子》、《儀禮》、《禮記》及後人顧頡剛的研究中都有説明。由於聲、詩不分，孔子既説「放鄭聲」，則鄭詩也應在被放之列，因為我們不能想像只有歌詞（詩），沒有音樂（聲）的「樂歌」。但現在我們看毛詩，鄭詩歷歷在目，則孔子何嘗删過詩？至於逸詩問題，本文作者認為可能在《詩經》四家之外，尚有其他版本家派，至今失傳，只留下一些佚文佚句，為今本毛詩所無，而由先秦學者引用，得以留存。1977年安徽阜陽出土的漢簡《詩經》，或者可以證明這點。阜詩與四家詩都不同，不禁使人懷疑它是否四家詩以外的另一版本。假如是的話，則逸詩的問題自可迎刃而解。而最主要的，阜陽詩經中收錄有鄭風八首，可見不論目前所見任何版本流派，都收錄了鄭風。由此，本文作者認為孔子删詩説是不可靠的，孔子其實並未删過詩。The Shi Ji (Historical Records) by Sima Qian of the Han Dynasty recorded that in ancient times, there were more than 3000 poems comprising the Shi Jing (Book of Songs). Later, according to tradition, Confucius edited the classic and reduced the number of poems to 305. Ever since Sima Qian’s record, there have been scholarly disputes supporting or rejecting the question of whether or not Confucius’ deletion of poems really took place. This dispute has been on-going for nearly 2000 years and has not been resolved. The present paper attempts to solve this problem by examining Confucius’ criteria and attitude in dealing with the Book of Songs. Confucius had once said that he would like to delete the music from the State of Zheng, because the music of that State was yin 淫 (salacious or exceeded the limit). This incident was first recorded in the Analects. The present paper suggests that in the first place music and lyrics from ancient times in the Book of Songs were inseparable. This point was mentioned in Xunzi, Mozi, Yi Li, and the Li Ji etc., and studies by Gu Jie-gang also supported this view. Since it was supposed that Confucius deleted the music of Zheng, it was unavoidable that the words (poems) that accompanied it would also be deleted, as the two were closely intertwined. Moreover, within that tradition, it was unthinkable to talk about a “song”, and have only words and no music. It thus can be argued that Confucius actually had never deleted these poems from the Book of Songs, as the Zheng poems still exist in the Mao edition of the classic. As to the question that other poems do exist in pre-Qin writings and cannot be found in the Mao edition, which scholars term yi-shi (lost poems), the present paper suggests that there may have been other editions of the Book of Songs in ancient times which are now mostly lost. Thus those poems that appear in pre-Qin writings actually come from other lost editions. The 1977 excavation of a Han Dynasty bamboo copy of the Shi Jing from Fu Yang, Anhui proves this point. The Fu Yang Shi Jing is different from the Si-Jia-Shi (the exiting four editions of the Book of Songs), and therefore it may have come from a different edition that was lost. If this is true, this is evidence to support the hypothesis of this paper as to why yi-shi were found in pre-Qin writings. Most importantly is that the Fu Yang Shi Jing recorded eight poems from the State of Zheng. Since all editions of the Shi Jing that exist today contain poems from Zheng, the present paper concludes that Confucius had never deleted poems from the Book of Songs. Therefore, Sima Qian’s statement in the Shi Ji is unreliable.

Graphene-based composites have received a great deal of attention in recent year because the presence of graphene can enhance the conductivity, strength of bulk materials and help create composites with superior qualities. Moreover, the incorporation of metal oxide nanoparticles such as Fe3O4 can improve the catalytic efficiency of composite material. In this work, we have synthesized a composite material with the combination of reduced graphene oxide (rGO), and Fe3O4 modified tissue-paper (mGO-PP) via a simple hydrothermal method, which improved the removal efficiency of the of methylene blue (MB) in water. MB blue is used as the model of contaminant to evaluate the catalytic efficiency of synthesized material by using a Fenton-like reaction. The obtained materials were characterized by SEM, XRD. The removal of materials with methylene blue is investigated by UV-VIS spectroscopy, and the result shows that mGO-PP composite is the potential composite for the color removed which has the removal efficiency reaching 65% in acetate buffer pH = 3 with the optimal time is 7 h. Keywords Graphene-based composite, methylene blue, Fenton-like reaction. References [1] Ma Joshi, Rue Bansal, Reng Purwar, Colour removal from textile effluents, Indian Journal of Fibre & Textile Research, 29 (2004) 239-259 http://nopr.niscair.res.in/handle/123456789/24631.[2] Kannan Nagar, Sundaram Mariappan, Kinetics and mechanism of removal of methylene blue by adsorption on various carbons-a comparative study, Dyes and pigments, 51 (2001) 25-40 https://doi.org/10.1016/S0143-7208(01)00056-0.[3] K Rastogi, J. N Sahu, B. C Meikap, M. N Biswas, Removal of methylene blue from wastewater using fly ash as an adsorbent by hydrocyclone, Journal of hazardous materials, 158 (2008) 531-540.https://doi.org/10.1016/j.jhazmat.2008.01. 105.[4] Qin Qingdong, Ma Jun, Liu Ke, Adsorption of anionic dyes on ammonium-functionalized MCM-41, Journal of Hazardous Materials, 162 (2009) 133-139 https://doi.org/10.1016/j.jhazmat. 2008.05.016.[5] Mui Muruganandham, Rps Suri, Sh Jafari, Mao Sillanpää, Lee Gang-Juan, Jaj Wu, Muo Swaminathan, Recent developments in homogeneous advanced oxidation processes for water and wastewater treatment, International Journal of Photoenergy, 2014 (2014). http://dx. doi.org/10.1155/2014/821674.[6] Herney Ramirez, Vicente Miguel , Madeira Luis Heterogeneous photo-Fenton oxidation with pillared clay-based catalysts for wastewater treatment: a review, Applied Catalysis B: Environmental, 98 (2010) 10-26 https://doi.org/ 10.1016/j.apcatb.2010.05.004.[7] Guo Rong, Jiao Tifeng, Li Ruifei, Chen Yan, Guo Wanchun, Zhang Lexin, Zhou Jingxin, Zhang Qingrui, Peng Qiuming, Sandwiched Fe3O4/carboxylate graphene oxide nanostructures constructed by layer-by-layer assembly for highly efficient and magnetically recyclable dye removal, ACS Sustainable Chemistry & Engineering, 6 (2017) 1279-1288 https://doi.org/10.1021/acssuschemeng.7b03635.[8] Sun Chao, Yang Sheng-Tao, Gao Zhenjie, Yang Shengnan, Yilihamu Ailimire, Ma Qiang, Zhao Ru-Song, Xue Fumin, Fe3O4/TiO2/reduced graphene oxide composites as highly efficient Fenton-like catalyst for the decoloration of methylene blue, Materials Chemistry and Physics, 223 (2019) 751-757 https://doi.org/ 10.1016/j.matchemphys.2018.11.056.[9] Guo Hui, Ma Xinfeng, Wang Chubei, Zhou Jianwei, Huang Jianxin, Wang Zijin, Sulfhydryl-Functionalized Reduced Graphene Oxide and Adsorption of Methylene Blue, Environmental Engineering Science, 36 (2019) 81-89 https://doi. org/10.1089/ees.2018.0157.[10] Zhao Lianqin, Yang Sheng-Tao, Feng Shicheng, Ma Qiang, Peng Xiaoling, Wu Deyi, Preparation and application of carboxylated graphene oxide sponge in dye removal, International journal of environmental research and public health, 14 (2017) 1301 https://doi.org/10.3390/ijerph14111301.[11] Yu Dandan, Wang Hua, Yang Jie, Niu Zhiqiang, Lu Huiting, Yang Yun, Cheng Liwei, Guo Lin, Dye wastewater cleanup by graphene composite paper for tailorable supercapacitors, ACS applied materials & interfaces, 9 (2017) 21298-21306 https://doi.org/10.1021/acsami.7b05318.[12] Wang Hou, Yuan Xingzhong, Wu Yan, Huang Huajun, Peng Xin, Zeng Guangming, Zhong Hua, Liang Jie, Ren MiaoMiao, Graphene-based materials: fabrication, characterization and application for the decontamination of wastewater and wastegas and hydrogen storage/generation, Advances in Colloid and Interface Science, 195 (2013) 19-40 https://doi. org/10.1016/j.cis.2013.03.009.[13] Marcano Daniela C, Kosynkin Dmitry V, Berlin Jacob M, Sinitskii Alexander, Sun Zhengzong, Slesarev Alexander, Alemany Lawrence B, Lu Wei, Tour James M, Improved synthesis of graphene oxide, ACS nano, 4 (2010) 4806-4814 https://doi.org/10.1021/nn1006368.[14] Zhang Jiali, Yang Haijun, Shen Guangxia, Cheng Ping, Zhang Jingyan, Guo Shouwu, Reduction of graphene oxide via L-ascorbic acid, Chemical Communications, 46 (2010) 1112-1114 http://doi. org/10.1039/B917705A [15] Gong Ming, Zhou Wu, Tsai Mon-Che, Zhou Jigang, Guan Mingyun, Lin Meng-Chang, Zhang Bo, Hu Yongfeng, Wang Di-Yan, Yang Jiang, Nanoscale nickel oxide/nickel heterostructures for active hydrogen evolution electrocatalysis, Nature communications, 5 (2014) 4695 https:// doi.org/10.1038/ncomms5695.[16] Wu Zhong-Shuai, Yang Shubin, Sun Yi, Parvez Khaled, Feng Xinliang, Müllen Klaus, 3D nitrogen-doped graphene aerogel-supported Fe3O4 nanoparticles as efficient electrocatalysts for the oxygen reduction reaction, Journal of the American Chemical Society, 134 (2012) 9082-9085 https://doi.org/10.1021/ja3030565.[17] Nguyen Son Truong, Nguyen Hoa Tien, Rinaldi Ali, Nguyen Nam Van, Fan Zeng, Duong Hai Minh, Morphology control and thermal stability of binderless-graphene aerogels from graphite for energy storage applications, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 414 (2012) 352-358 https://doi.org/ 10.1016/j.colsurfa.2012.08.048.[18] Deng Yang, Englehardt James D, Treatment of landfill leachate by the Fenton process, Water research, 40 (2006) 3683-3694 https://doi.org/ 10.1016/j.watres.2006.08.009.