Journal articles on the topic 'Xanthophylls'
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Gao, Yu-Yun, Qing-Mei Xie, Jing-Yun Ma, Xiang-Bin Zhang, Ji-Mei Zhu, Ding-Ming Shu, Bao-Li Sun, Ling Jin, and Ying-Zuo Bi. "Supplementation of xanthophylls increased antioxidant capacity and decreased lipid peroxidation in hens and chicks." British Journal of Nutrition 109, no. 6 (July 19, 2012): 977–83. http://dx.doi.org/10.1017/s0007114512002784.
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The present study investigated the effects of xanthophyll supplementation on production performance, antioxidant capacity (measured by glutathione peroxidase, superoxide dismutase (SOD), catalase, total antioxidant capacity (T-AOC), and reduced glutathione:oxidised glutathione ratio (GSH:GSSG)) and lipid peroxidation (measured by malondialdehyde (MDA)) in breeding hens and chicks. In Expt 1, 432 hens were fed diets supplemented with 0 (control group), 20 or 40 mg xanthophyll/kg diet. Blood samples were taken at 7, 14, 21, 28 and 35 d of the trial. Liver and jejunal mucosa were sampled at 35 d. Both xanthophyll groups improved serum SOD at 21 and 28 d, serum T-AOC at 21 d and liver T-AOC, and serum GSH:GSSG at 21, 28 and 35 d and liver GSH:GSSG. Xanthophylls also decreased serum MDA at 21 d in hens. Expt 2 was a 2 × 2 factorial design. Male chicks hatched from 0 or 40 mg in ovo xanthophyll/kg diet of hens were fed a diet containing either 0 or 40 mg xanthophyll/kg diet. Liver samples were collected at 0, 7, 14 and 21 d after hatching. Blood samples were also collected at 21 d. In ovo-deposited xanthophylls increased antioxidant capacity and decreased MDA in the liver mainly within 1 week after hatching. Maternal effects gradually vanished during 1–2 weeks after hatching. Dietary xanthophylls increased antioxidant capacity and decreased MDA in the liver and serum mainly from 2 weeks onwards. Data suggested that xanthophyll supplementation enhanced antioxidant capacity and reduced lipid peroxidation in different tissues of hens and chicks.
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Breithaupt, Dietmar E., Elhadi M. Yahia, and Francisco J. Valdés Velázquez. "Comparison of the absorption efficiency of α- and β-cryptoxanthin in female Wistar rats." British Journal of Nutrition 97, no. 2 (February 2007): 329–36. http://dx.doi.org/10.1017/s0007114507336751.
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Xanthophylls, such as lutein and zeaxanthin, have received increasing interest in recent years because of positive correlations between their consumption and the prevention of eye diseases. Numerous human intervention studies have been conducted with lutein to estimate the bioavailability from different formulations. The present study was designed to obtain basic data on the absorbance efficiency of the monohydroxylated counterparts of lutein and zeaxanthin: α- and β-cryptoxanthin. A corn-oil-based diet comprising ß-cryptoxanthin from papaya purée and α-cryptoxanthin from green carrot leaves was fed to five female Wistar rats for 8 consecutive days at a rate of 17·3 nmol/d and 9·2 nmol/d, respectively. The identity of the xanthophylls in the supplement was ascertained by LC-(APCI)MS analyses, and xanthophylls present in liver and plasma samples were determined by HPLC/diode array detector (DAD). The β-cryptoxanthin concentrations of rat livers in the treatment group were statistically distinguishable (P < 0·01) from those present in the livers of the control group that were fed a basic diet. α-Cryptoxanthin, the second xanthophyll present in the supplement, was not found in rat livers in the treatment group. Plasma samples were free of xanthophylls. This is the first report proving that β-cryptoxanthin has a higher absorption efficiency than α-cryptoxanthin in rats, at least from a minimally processed oil-based xanthophyll supplement.
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Thurnham, David I. "Macular zeaxanthins and lutein – a review of dietary sources and bioavailability and some relationships with macular pigment optical density and age-related macular disease." Nutrition Research Reviews 20, no. 2 (December 2007): 163–79. http://dx.doi.org/10.1017/s0954422407842235.
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The retina is unique in the human body in containing three xanthophyll carotenoids; 3R,3′R-zeaxanthin, meso-zeaxanthin (MZ) and lutein. Humans consume 1 to 3 mg lutein per d and the lutein:zeaxanthin ratio in the diet is about 5:1.Xanthophyll pigments occur widely in vegetables and fruits but MZ is found in only a few foods such as the shrimp carapace and fish skin. In spite of the amounts of the different xanthophylls in the diet, zeaxanthin and MZ occur in approximately equal amounts in the eye, and their combined concentration can exceed that of lutein. In the present review the bioavailablity of zeaxanthin and lutein is assessed using the plasma xanthophyll response to dietary intervention. A number of studies have used single and mixed sources of the pure xanthophylls to achieve steady-state plasma responses. Mostly these have been with lutein and zeaxanthin but two using MZ are also described. Responses following the intervention with the pure xanthophylls are compared with those following food intervention. Vegetables are the richest source of dietary lutein and several vegetable-feeding studies are discussed. Intervention studies with eggs, which are a good source of zeaxanthin, suggest that the xanthophyll carotenoids in egg yolk may be more bioavailable than those in other foods and are described separately. MZ has been a component of a xanthophyll supplement added to chicken feed in Mexico in the last 10 years. Egg consumption in Mexico is approximately one egg/person per d and the potential contribution of this food source of MZ to Mexican dietary intakes is described. Very limited information from human feeding studies of MZ-containing supplements suggests that MZ is less well absorbed than zeaxanthin. However, MZ is unusual in the diet and not reported in the plasma. Thus plasma responses may not reflect true absorption if it takes MZ longer to equilibrate with body tissues than the other xanthophylls and competition with zeaxanthin may lower the relative concentrations of MZ in plasma. Lastly, the effects of long-term feeding with both pure and food sources of the xanthophyll pigments on macular pigment optical density is compared and the importance of previous dietary intake on the effects of intervention is discussed.
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Scripsema, Nicole K., Dan-Ning Hu, and Richard B. Rosen. "Lutein, Zeaxanthin, andmeso-Zeaxanthin in the Clinical Management of Eye Disease." Journal of Ophthalmology 2015 (2015): 1–13. http://dx.doi.org/10.1155/2015/865179.
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Lutein, zeaxanthin, andmeso-zeaxanthin are xanthophyll carotenoids found within the retina and throughout the visual system. The retina is one of the most metabolically active tissues in the body. The highest concentration of xanthophylls is found within the retina, and this selective presence has generated many theories regarding their role in supporting retinal function. Subsequently, the effect of xanthophylls in the prevention and treatment of various eye diseases has been examined through epidemiological studies, animal studies, and clinical trials. This paper attempts to review the epidemiological studies and clinical trials investigating the effects of xanthophylls on the incidence and progression of various eye diseases. Observational studies have reported that increased dietary intake and higher serum levels of lutein and zeaxanthin are associated with lower risk of age-related macular degeneration (AMD), especially late AMD. Randomized, placebo-controlled clinical trials have demonstrated that xanthophyll supplementation increases macular pigment levels, improves visual function, and decreases the risk of progression to late AMD, especially neovascular AMD. Current publications on the preventive and therapeutic effects of lutein and zeaxanthin on cataracts, diabetic retinopathy, and retinopathy of prematurity have reported encouraging results.
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Gao, Yu-Yun, Qing-Mei Xie, Ling Jin, Bao-Li Sun, Jun Ji, Feng Chen, Jing-Yun Ma, and Ying-Zuo Bi. "Supplementation of xanthophylls decreased proinflammatory and increased anti-inflammatory cytokines in hens and chicks." British Journal of Nutrition 108, no. 10 (January 25, 2012): 1746–55. http://dx.doi.org/10.1017/s0007114512000025.
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The present study investigated the effects of xanthophylls (containing 40 % of lutein and 60 % of zeaxanthin) on proinflammatory cytokine (IL-1β, IL-6, interferon (IFN)-γ and lipopolysaccharide-induced TNF-α factor (LITAF)) and anti-inflammatory cytokine (IL-4 and IL-10) expression of breeding hens and chicks. In Expt 1, a total of 432 hens were fed diets supplemented with 0 (as the control group), 20 or 40 mg/kg xanthophylls (six replicates per treatment). The liver, duodenum, jejunum and ileum were sampled at 35 d of the trial. The results showed that both levels of xanthophyll addition decreased IL-1β mRNA in the liver and jejunum, IL-6 mRNA in the liver, IFN-γ mRNA in the jejunum and LITAF mRNA in the liver compared to the control group. Expt 2 was a 2 × 2 factorial design. Male chicks hatched from 0 or 40 mg/kg xanthophyll diet of hens were fed a diet containing either 0 or 40 mg/kg xanthophylls. The liver, duodenum, jejunum and ileum were collected at 0, 7, 14 and 21 d after hatching. The results showed thatin ovoxanthophylls decreased proinflammatory cytokine expression (IL-1β, IL-6, IFN-γ and LITAF) in the liver, duodenum, jejunum and ileum and increased anti-inflammatory cytokine expression (IL-4 and IL-10) in the liver, jejunum and ileum mainly at 0–7 d after hatching.In ovoeffects gradually vanished and dietary effects began to work during 1–2 weeks after hatching. Dietary xanthophylls modulated proinflammatory cytokines (IL-1β, IL-6 and IFN-γ) in the liver, duodenum, jejunum and ileum and anti-inflammatory cytokine (IL-10) in the liver and jejunum mainly from 2 weeks onwards. In conclusion, xanthophylls could regulate proinflammatory and anti-inflammatory cytokine expression in different tissues of hens and chicks.
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Close, Dugald C., Chris L. Beadle, and Mark J. Hovenden. "Cold-induced photoinhibition and foliar pigment dynamics of Eucalyptus nitens seedlings during establishment." Functional Plant Biology 28, no. 11 (2001): 1133. http://dx.doi.org/10.1071/pp01039.
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The effects of cold-induced photoinhibition on chlorophyll and carotenoid dynamics and xanthophyll cycling in Eucalyptus nitens (Deane and Maiden) Maiden were assessed between planting and 32 weeks after planting. The seedlings were fertilised or nutrient-deprived (non-fertilised) before planting and shaded or not shaded after planting. The experimental site was 700 m a.s.l., which is considered marginal for establishment of E. nitens plantations in Tasmania due to low mean annual minimum temperatures. Low temperature–high light conditions caused a reduction in variable to maximal chlorophyll fluorescence ratio (F v /F m ), which was more pronounced in non-fertilised than in fertilised seedlings. Shadecloth shelters alleviated this depression. Except in shaded fertilised seedlings, F v /F m did not recover to the level before planting until after 20 weeks. Total chlorophyll content was initially reduced in shaded treatments but subsequently increased with increasing temperatures and F v /F m. Total xanthophyll content and xanthophylls per unit chlorophyll remained relatively constant in fertilised seedlings but decreased in non-fertilised seedlings within 2 weeks after planting. Total xanthophyll and xanthophylls per unit chlorophyll subsequently recovered in non-shaded, non-fertilised seedlings with increasing temperatures and F v /F m. Diurnal [yield and non-photochemical quenching (NPQ) and seasonal (F v /F m) variation in chlorophyll fluorescence parameters were not reflected in xanthophyll cycling during the period of most severe photoinhibition. This result may indicate that chlorophyll–xanthophylls protein complexes form in winter-acclimated E. nitens foliage as have been demonstrated to occur in Eucalyptus pauciflora Sieb. ex Spreng. (Gilmore and Ball 2000, Proceedings of the National Academy of Sciences USA 97, 11098–11101).
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Kotake-Nara, Eiichi, and Akihiko Nagao. "Absorption and Metabolism of Xanthophylls." Marine Drugs 9, no. 6 (June 10, 2011): 1024–37. http://dx.doi.org/10.3390/md9061024.
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Dietary carotenoids, especially xanthophylls, have attracted significant attention because of their characteristic biological activities, including anti-allergic, anti-cancer, and anti-obese actions. Although no less than forty carotenoids are ingested under usual dietary habits, only six carotenoids and their metabolites have been found in human tissues, suggesting selectivity in the intestinal absorption of carotenoids. Recently, facilitated diffusion in addition to simple diffusion has been reported to mediate the intestinal absorption of carotenoids in mammals. The selective absorption of carotenoids may be caused by uptake to the intestinal epithelia by the facilitated diffusion and an unknown excretion to intestinal lumen. It is well known that β-carotene can be metabolized to vitamin A after intestinal absorption of carotenoids, but little is known about the metabolic transformation of non provitamin A xanthophylls. The enzymatic oxidation of the secondary hydroxyl group leading to keto-carotenoids would occur as a common pathway of xanthophyll metabolism in mammals. This paper reviews the absorption and metabolism of xanthophylls by introducing recent advances in this field.
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Pereira, Antia G., Paz Otero, Javier Echave, Anxo Carreira-Casais, Franklin Chamorro, Nicolas Collazo, Amira Jaboui, Catarina Lourenço-Lopes, Jesus Simal-Gandara, and Miguel A. Prieto. "Xanthophylls from the Sea: Algae as Source of Bioactive Carotenoids." Marine Drugs 19, no. 4 (March 27, 2021): 188. http://dx.doi.org/10.3390/md19040188.
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Algae are considered pigment-producing organisms. The function of these compounds in algae is to carry out photosynthesis. They have a great variety of pigments, which can be classified into three large groups: chlorophylls, carotenoids, and phycobilins. Within the carotenoids are xanthophylls. Xanthophylls (fucoxanthin, astaxanthin, lutein, zeaxanthin, and β-cryptoxanthin) are a type of carotenoids with anti-tumor and anti-inflammatory activities, due to their chemical structure rich in double bonds that provides them with antioxidant properties. In this context, xanthophylls can protect other molecules from oxidative stress by turning off singlet oxygen damage through various mechanisms. Based on clinical studies, this review shows the available information concerning the bioactivity and biological effects of the main xanthophylls present in algae. In addition, the algae with the highest production rate of the different compounds of interest were studied. It was observed that fucoxanthin is obtained mainly from the brown seaweeds Laminaria japonica, Undaria pinnatifida, Hizikia fusiformis, Sargassum spp., and Fucus spp. The main sources of astaxanthin are the microalgae Haematococcus pluvialis, Chlorella zofingiensis, and Chlorococcum sp. Lutein and zeaxanthin are mainly found in algal species such as Scenedesmus spp., Chlorella spp., Rhodophyta spp., or Spirulina spp. However, the extraction and purification processes of xanthophylls from algae need to be standardized to facilitate their commercialization. Finally, we assessed factors that determine the bioavailability and bioaccesibility of these molecules. We also suggested techniques that increase xanthophyll’s bioavailability.
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Thomas, Sara E., and Elizabeth J. Johnson. "Xanthophylls." Advances in Nutrition 9, no. 2 (March 1, 2018): 160–62. http://dx.doi.org/10.1093/advances/nmx005.
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Kruk, Jerzy, and Renata Szymańska. "Occurrence of neoxanthin and lutein epoxide cycle in parasitic Cuscuta species." Acta Biochimica Polonica 55, no. 1 (January 24, 2008): 183–90. http://dx.doi.org/10.18388/abp.2008_3111.
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In the present study, xanthophyll composition of eight parasitic Cuscuta species under different light conditions was investigated. Neoxanthin was not detected in four of the eight species examined, while in others it occurred at the level of several percent of total xanthophylls. In C. gronovii and C. lupuliformis it was additionally found that the neoxanthin content was considerably stimulated by strong light. In dark-adapted plants, lutein epoxide level amounted to 10-22% of total xanthophylls in only three species, the highest being for C. lupuliformis, while in others it was below 3%, indicating that the lutein epoxide cycle is limited to only certain Cuscuta species. The obtained data also indicate that the presence of the lutein epoxide cycle and of neoxanthin is independent and variable among the Cuscuta species. The xanthophyll cycle carotenoids violaxanthin, antheraxanthin and zeaxanthin were identified in all the examined species and occurred at the level found in other higher plants. The xanthophyll and lutein epoxide cycle pigments showed typical response to high light stress. The obtained results also suggest that the ability of higher plants to synthesize lutein epoxide probably does not depend on the substrate specificity of zeaxanthin epoxidase but on the availability of lutein for the enzyme.
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Gleize, Béatrice, Franck Tourniaire, Laurence Depezay, Romain Bott, Marion Nowicki, Lionel Albino, Denis Lairon, et al. "Effect of type of TAG fatty acids on lutein and zeaxanthin bioavailability." British Journal of Nutrition 110, no. 1 (December 11, 2012): 1–10. http://dx.doi.org/10.1017/s0007114512004813.
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The xanthophylls lutein and zeaxanthin probably play a role in visual function and may participate in the prevention of age-related eye diseases. Although a minimum amount of TAG is required for an optimal bioavailability of these carotenoids, the effect of the type of TAG fatty acids (FA) is less clear. The aim was to assess the effect of the type of TAG FA on bioavailability of these xanthophylls. A total of three complementary models were used: an in vitro digestion model to study bioaccessibility, Caco-2 cells to study uptake efficiency and orally administered rats to study in vivo bioavailability. Results showed that lutein and zeaxanthin bioaccessibility was greater (about 20–30 %, P< 0·05) with butter and palm oil than with olive and fish oils. Mixed micelle size, which was significantly lower (about 8 %, P< 0·05) with SFA than with unsaturated FA, was inversely related to lutein and zeaxanthin bioaccessibility. There was no significant effect of the type of TAG FA on xanthophyll uptake by Caco-2 cells, but some compounds present in natural oils significantly affected xanthophyll uptake. Oral administration of rats with spinach and butter over 3 d led to a higher fasting plasma lutein concentration than oral administration with olive or fish oils. In conclusion, dietary fats rich in SFA lead to a higher bioavailability of lutein and zeaxanthin, as compared with fats rich in MUFA and PUFA. This is due partly to the higher bioaccessibility of these xanthophylls in the smaller mixed micelles produced when SFA are incorporated into mixed micelles.
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Bhosale, Prakash, and Paul S. Bernstein. "Microbial xanthophylls." Applied Microbiology and Biotechnology 68, no. 4 (July 7, 2005): 445–55. http://dx.doi.org/10.1007/s00253-005-0032-8.
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Kashi, Monica, Caitlyn Edwards, Sharon Thompson, John Erdman Jr., Nicholas Burd, Hannah Holscher, and Naiman Khan. "Differential Relationships Between Serum Xanthophylls and Macular Pigment and Retinal Morphology." Current Developments in Nutrition 4, Supplement_2 (May 29, 2020): 114. http://dx.doi.org/10.1093/cdn/nzaa041_018.
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Abstract Objectives Lutein and zeaxanthin are xanthophyll carotenoids that comprise macular pigment in the eye and disproportionately accumulate in brain tissue. While the link between serum xanthophylls and macular pigment has received considerable investigation, comparatively less is known regarding the relationship between circulating xanthophylls and retinal morphology. This knowledge gap is significant since deterioration of the morphometric measures of the retina (e.g., retinal nerve fiber layer, RNFL) is a feature of age-neurodegenerative diseases. This project aimed to understand the relationship between serum xanthophylls and retinal morphology. Methods Subjects included 84 individuals (30 males) with overweight and obesity (BMI ≥ 25 kg/m2) between 25–45 years. Macular pigment optical density (MPOD) was measured using heterochromatic flicker photometry. Optical coherence tomography (OCT) was used to assess RNFL, ganglion cell layer (GCL), and inner plexiform layer (IPL). Venous blood draws were used to assess serum lutein and zeaxanthin. Covariates assessed included demographic factors, adiposity (DXA), and dietary intake (7d food records). Results Serum lutein (r = 0.32, P < 0.01) and zeaxanthin (r = 0.23, P = 0.01) concentrations were associated with greater MPOD. There were no significant associations between serum xanthophyll concentrations and morphological values. Similarly, there was no influence of adiposity or dietary lutein and zeaxanthin on retinal morphological measures. However, overall diet quality, assessed using Healthy Eating Index (HEI) was positively associated with IPL (r = 0.35, P < 0.01) and GCL (r = 0.32, P < 0.01) thickness. Conclusions Although circulating carotenoids were associated with macular pigment, this relationship did not extend to morphological measures in the retina. However, overall dietary quality was significantly associated with retinal morphological measures. These findings suggest that macular pigment and retinal morphology may be influenced by nutritional factors. Funding Sources Hass Avocado Board.
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Pogson, Barry J., and Heather M. Rissler. "Genetic manipulation of carotenoid biosynthesis and photoprotection." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 355, no. 1402 (October 29, 2000): 1395–403. http://dx.doi.org/10.1098/rstb.2000.0701.
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There are multiple complementary and redundant mechanisms to provide protection against photooxidative damage, including non–photochemical quenching (NPQ). NPQ dissipates excess excitation energy as heat by using xanthophylls in combination with changes to the light–harvesting complex (LHC) antenna. The xanthophylls are oxygenated carotenoids that in addition to contributing to NPQ can quench singlet or triplet chlorophyll and are necessary for the assembly and stability of the antenna. We have genetically manipulated the expression of the ε–cyclase and β–carotene hydroxylase carotenoid biosynthetic enzymes in Arabidopsis thaliana . The ε–cyclase overexpression confirmed that lut2 (lutein deficient) is a mutation in the ε–cyclase gene and demonstrated that lutein content can be altered at the level of mRNA abundance with levels ranging from 0 to 180% of wild–type. Also, it is clear that lutein affects the induction and extent of NPQ. The deleterious effects of lutein deficiency on NPQ in Arabidopsis and Chlamydomonas are additive, no matter what the genetic background, whether npq1 (zeaxanthin deficient), aba1 or antisense β–hydroxylase (xanthophyll cycle pool decreased). Additionally, increasing lutein content causes a marginal, but significant, increase in the rate of induction of NPQ despite a reduction in the xanthophyll cycle pool size.
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Piña, Florentina, and Loretto Contreras-Porcia. "Enhancement of Xanthophyll Synthesis in Porphyra/Pyropia Species (Rhodophyta, Bangiales) by Controlled Abiotic Factors: A Systematic Review and Meta-Analysis." Marine Drugs 19, no. 4 (April 15, 2021): 221. http://dx.doi.org/10.3390/md19040221.
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Red alga species belonging to the Porphyra and Pyropia genera (commonly known as Nori), which are widely consumed and commercialized due to their high nutritional value. These species have a carotenoid profile dominated by xanthophylls, mostly lutein and zeaxanthin, which have relevant benefits for human health. The effects of different abiotic factors on xanthophyll synthesis in these species have been scarcely studied, despite their health benefits. The objectives of this study were (i) to identify the abiotic factors that enhance the synthesis of xanthophylls in Porphyra/Pyropia species by conducting a systematic review and meta-analysis of the xanthophyll content found in the literature, and (ii) to recommend a culture method that would allow a significant accumulation of these compounds in the biomass of these species. The results show that salinity significantly affected the content of total carotenoids and led to higher values under hypersaline conditions (70,247.91 µg/g dm at 55 psu). For lutein and zeaxanthin, the wavelength treatment caused significant differences between the basal and maximum content (4.16–23.47 µg/g dm). Additionally, in Pyropia spp., the total carotenoids were considerably higher than in Porphyra spp.; however, the lutein and zeaxanthin contents were lower. We discuss the specific conditions for each treatment and the relation to the ecological distribution of these species.
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Jeong, Sun Wook, Jung Eun Yang, and Yong Jun Choi. "Isolation and Characterization of a Yellow Xanthophyll Pigment-Producing Marine Bacterium, Erythrobacter sp. SDW2 Strain, in Coastal Seawater." Marine Drugs 20, no. 1 (January 14, 2022): 73. http://dx.doi.org/10.3390/md20010073.
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Xanthophylls, a yellow pigment belonging to the carotenoid family, have attracted much attention for industrial applications due to their versatile nature. We report the isolation of a homo xanthophyll pigment-producing marine bacterium, identified as the Erythrobacter sp. SDW2 strain, from coastal seawater. The isolated Erythrobacter sp. SDW2 strain can produce 263 ± 12.9 mg/L (89.7 ± 5.4 mg/g dry cell weight) of yellow xanthophyll pigment from 5 g/L of glucose. Moreover, the xanthophyll pigment produced by the SDW2 strain exhibits remarkable antioxidative activities, confirmed by the DPPH (73.4 ± 1.4%) and ABTS (84.9 ± 0.7%) assays. These results suggest that the yellow xanthophyll pigment-producing Erythrobacter sp. SDW2 strain could be a promising industrial microorganism for producing marine-derived bioactive compounds with potential for foods, cosmetics, and pharmaceuticals.
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Baroli, Irene, and Krishna K. Niyogi. "Molecular genetics of xanthophyll–dependent photoprotection in green algae and plants." Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences 355, no. 1402 (October 29, 2000): 1385–94. http://dx.doi.org/10.1098/rstb.2000.0700.
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The involvement of excited and highly reactive intermediates in oxygenic photosynthesis inevitably results in the generation of reactive oxygen species. To protect the photosynthetic apparatus from oxidative damage, xanthophyll pigments are involved in the quenching of excited chlorophyll and reactive oxygen species, namely 1 Chl*, 3 Chl*, and 1 1O 2 *. Quenching of 1 Chl* results in harmless dissipation of excitation energy as heat and is measured as non–photochemical quenching (NPQ) of chlorophyll fluorescence. The multiple roles of xanthophylls in photoprotection are being addressed by characterizing mutants of Chlamydomonas reinhardtii and Arabidopsis thaliana . Analysis of Arabidopsis mutants that are defective in 1 Chl* quenching has shown that, in addition to specific xanthophylls, the psbS gene is necessary for NPQ. Double mutants of Chlamydomonas and Arabidopsis that are deficient in zeaxanthin, lutein and NPQ undergo photo–oxidative bleaching in high light. Extragenic suppressors of the Chlamydomonas npq1 lor1 double mutant identify new mutations that restore varying levels of zeaxanthin accumulation and allow survival in high light.
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Widomska, Justyna, Wieslaw I. Gruszecki, and Witold K. Subczynski. "Factors Differentiating the Antioxidant Activity of Macular Xanthophylls in the Human Eye Retina." Antioxidants 10, no. 4 (April 14, 2021): 601. http://dx.doi.org/10.3390/antiox10040601.
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Macular xanthophylls, which are absorbed from the human diet, accumulate in high concentrations in the human retina, where they efficiently protect against oxidative stress that may lead to retinal damage. In addition, macular xanthophylls are uniquely spatially distributed in the retina. The zeaxanthin concentration (including the lutein metabolite meso-zeaxanthin) is ~9-fold greater than lutein concentration in the central fovea. These numbers do not correlate at all with the dietary intake of xanthophylls, for which there is a dietary zeaxanthin-to-lutein molar ratio of 1:12 to 1:5. The unique spatial distributions of macular xanthophylls—lutein, zeaxanthin, and meso-zeaxanthin—in the retina, which developed during evolution, maximize the protection of the retina provided by these xanthophylls. We will correlate the differences in the spatial distributions of macular xanthophylls with their different antioxidant activities in the retina. Can the major protective function of macular xanthophylls in the retina, namely antioxidant actions, explain their evolutionarily determined, unique spatial distributions? In this review, we will address this question.
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Ahmed, Shazia S., McGregor N. Lott, and Dennis M. Marcus. "The Macular Xanthophylls." Survey of Ophthalmology 50, no. 2 (March 2005): 183–93. http://dx.doi.org/10.1016/j.survophthal.2004.12.009.
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Lu, Peiran, Siau Yen Wong, Jianmin Chai, Lei Wu, Brenda Smith, Edralin Lucas, Stephen L. Clarke, et al. "Xanthophylls Shift the Gut Microbiota and Reduce Inflammation in Mice During Influenza A Virus Infection." Current Developments in Nutrition 5, Supplement_2 (June 2021): 76. http://dx.doi.org/10.1093/cdn/nzab034_010.
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Abstract Objectives Seasonal influenza A virus (IAV) infection impacts both respiratory and intestinal microbiome homeostasis. However, it is not well understood the extent to which the gut-lung axis plays the role in innate immunity and acute inflammation during IAV. Xanthophylls are fat-soluble, oxygenized carotenoids with potent antioxidant properties. We recently reported that xanthophylls can promote gut microbiome homeostasis and is associated with attenuation of intestinal and systemic inflammation. Here, we sought to investigate the protective effects of xanthophylls, e.g., zeaxanthin (Z) and astaxanthin (A) in IAV pneumonia by regulation of the host gut microbiome. Methods Six-week-old male and female 129S6 wild type (WT) and beta-carotene oxygenase 2 (BCO2) knockout mice were fed with AIN93M chow diets supplemented with or without Z (0.02% w/w) and A (0.02 w/w) (e.g., A + Z). After 6 weeks of the dietary intervention, mice were intranasally infected with 100 pfu H1N1 PR8 virus. Animal body weight and phenotypes were monitored daily. Animals were sacrificed 6 days post-infection. Blood and lung tissues were collected for experiments. H & E staining, gut microbiota 16S rRNA sequencing, immunohistochemistry, and immunoblotting were used for clinical, histopathological, and other biochemical assessments. Results Depletion of BCO2, the xanthophyll cleavage enzyme, made mice more resistant to IAV infection. Administration of A + Z caused A + Z accumulation and enhanced resistance to IAV in BCO2 KO but not WT mice, as demonstrated by histological lung damage and colon and ileum inflammation. Gut microbiome profiling results showed that α–diversity and β–diversity were significantly altered in these experimental groups. In particular, A + Z accumulation is positively associated with Bacteroides abundance. The increases in Bacteroides abundance were even greater in BCO2 KO mice, compared to the WT. Furthermore, Akkermansia abundance was significantly increased in BCO2 KO mice after IAV infection. Conclusions Association of xanthophyll accumulation with the gut microbiota shift could protect animals from IAV infection by reducing local inflammation. Bacteroides potentially plays a beneficial role in this process. Funding Sources USDA/NIFA 2021-67018-34023 and 2020-67017-30842.
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Huang, Mei, Ling Zhi Jiang, and Yan Fei Wei. "Preparative Separation of Xanthophylls from Corn Gluten Meal by Macoroporous Adsorption Resins in Biochemical Engineering." Advanced Materials Research 577 (October 2012): 105–8. http://dx.doi.org/10.4028/www.scientific.net/amr.577.105.
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To purify xanthophylls from corn gluten meal by macoroporous resins, the static adsorption performance and dynamic separation characteristics of different resins have been evaluated. And SD300 resin offers the best adsorption capacity for xanthophylls than the other resins as HZ816, S8, AB8 and D630. Based on sorption isotherms of SD300, the Freundlich equation was found to fit the experimental data more adequately. Then packed bed column with SD300 resin was used to perform dynamic adsorption and desorption tests to optimize the separation process of xanthophylls. Parameters for adsorption were sample solution xanthophylls concentration 128.9μg/ml, processing volume 11 BV, flow rate 1.0 BV/h, temperature 25°C. After being treated with ethyl acetate, the xanthophylls content in the product was increased to 6.1%, with a recovery yield of 74.0%.
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Jordan, Leonie, Andrew McMinn, and Peter Thompson. "Diurnal changes of photoadaptive pigments in microphytobenthos." Journal of the Marine Biological Association of the United Kingdom 90, no. 5 (October 21, 2009): 1025–32. http://dx.doi.org/10.1017/s0025315409990816.
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Microphytobenthos need photoadaptive strategies to survive the highly dynamic light environment in which they reside. Xanthophyll pigments can provide photoprotection by cycling electrons between epoxide and de-epoxide forms, dissipating excess light energy as heat. This study examined the xanthophyll cycle in microphytobenthos on a tidally exposed substrate at Browns River, Tasmania. Fv/Fm decreased from 0.52±0.01 to 0.47±0.01 at noon in surface samples and a decrease in the diadinoxanthin:chlorophyll-a ratio from 0.022±0.003 to 0.015±0.005 also suggests that the microphytobenthos was under physiological stress at noon. The results indicate that the cells exposed to light at the surface migrated deeper into the sediments and replenished the epoxide form of their xanthophylls. The results suggest that micrphytobenthos utilizes both behavioural and physiological strategies to survive in the dynamic intertidal environment.
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PAPA, C. M., D. L. FLETCHER, and H. R. HALLORAN. "Utilization and Yolk Coloring Capability of Xanthophylls from Synthetic and High Xanthophyll Concentrates." Poultry Science 64, no. 8 (August 1985): 1464–69. http://dx.doi.org/10.3382/ps.0641464.
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Cerna, Jonathan, Nikta S. Athari Anaraki, Connor M. Robbs, Brynn C. Adamson, Isabel R. Flemming, John W. Erdman, Leanne T. Labriola, Robert W. Motl, and Naiman A. Khan. "Macular Xanthophylls and Markers of the Anterior Visual Pathway among Persons with Multiple Sclerosis." Journal of Nutrition 151, no. 9 (June 4, 2021): 2680–88. http://dx.doi.org/10.1093/jn/nxab164.
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ABSTRACT Background Multiple sclerosis (MS) can cause retinal thinning among persons with MS with optic neuritis (MS-ON). Macular xanthophylls are carotenoids that comprise the macular pigment, filtering blue light and countering photo-oxidation. However, macular xanthophyll status and its implications for markers of neuroaxonal degeneration have not been examined in MS. Objectives This study characterized differences in macular and serum xanthophylls, and retinal morphometry [retinal nerve fiber layer thickness at the macular (mRNFL) and optic disc (odRNFL) and total macular volume (TMV)] in individuals with MS and healthy controls (HC). Associations between macular pigment optical density (MPOD) and retinal morphometry were also examined. Methods Adults aged 45–64 y (HC, n = 42; MS, n = 40) participated in a cross-sectional study. MPOD was measured via heterochromatic flicker photometry. Retinal morphometry was measured via optical coherence tomography (OCT). Serum carotenoids were quantified using HPLC. Dietary carotenoids were collected using 7-d records. One-factor ANOVA was conducted to determine group effects on macular, serum, and dietary carotenoids. Partial correlations examined the relations between MPOD, retinal morphometry, diet, and serum carotenoids. Results Relative to HC, persons with MS-ON had lower MPOD (Cohen's d = 0.84, P = 0.014), lower odRNFL (Cohen's d = 2.16, P <0.001), lower mRNFL (Cohen's d = 0.57, P = 0.028), and lower TMV (Cohen's d = 0.95, P = 0.011). MS without ON (MS) had lower odRNFL (Cohen's d = 0.93, P = 0.001) than HC and lower serum lutein than MS-ON subjects (Cohen's d = 0.65, P = 0.014). Among MS, MPOD was positively correlated with odRNFL thickness (ρ = 0.43, P = 0.049) and TMV (ρ = 0.45, P = 0.039), whereas odRNFL was negatively correlated with serum lutein (ρ = −0.68, P = 0.016) and zeaxanthin (ρ = –0.62, P = 0.028). Conclusions Persons with MS-ON exhibited poorer xanthophyll status in the macula and serum. MPOD was associated with beneficial anatomical features in the MS group. These findings warrant confirmation with larger cohorts and prospective trials to evaluate xanthophyll effects on the anterior visual pathway in MS.
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ACAR, N. "Protective role of xanthophylls." Acta Ophthalmologica 88 (September 2010): 0. http://dx.doi.org/10.1111/j.1755-3768.2010.4212.x.
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Galinato, Mary Grace I., Dariusz Niedzwiedzki, Cailin Deal, Robert R. Birge, and Harry A. Frank. "Cation radicals of xanthophylls." Photosynthesis Research 94, no. 1 (July 19, 2007): 67–78. http://dx.doi.org/10.1007/s11120-007-9218-5.
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Uppal, Sheetal, Sergey A. Dergunov, Weiyu Zhang, Susan Gentleman, T. Michael Redmond, Eugene Pinkhassik, and Eugenia Poliakov. "Xanthophylls Modulate Palmitoylation of Mammalian β-Carotene Oxygenase 2." Antioxidants 10, no. 3 (March 9, 2021): 413. http://dx.doi.org/10.3390/antiox10030413.
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An extensive body of work has documented the antioxidant role of xanthophylls (lutein and zeaxanthin) in human health and specifically how they provide photoprotection in human vision. More recently, evidence is emerging for the transcriptional regulation of antioxidant response by lutein/lutein cleavage products, similar to the role of β-carotene cleavage products in the modulation of retinoic acid receptors. Supplementation with xanthophylls also provides additional benefits for the prevention of age-related macular degeneration (AMD) and attenuation of Alzheimer’s disease symptoms. Mammalian β-carotene oxygenase 2 (BCO2) asymmetrically cleaves xanthophylls as well as β-carotene in vitro. We recently demonstrated that mouse BCO2 (mBCO2) is a functionally palmitoylated enzyme and that it loses palmitoylation when cells are treated with β-carotene. The mouse enzyme is the easiest model to study mammalian BCO2 because it has only one isoform, unlike human BCO2 with several major isoforms with various properties. Here, we used the same acyl-RAC methodology and confocal microscopy to elucidate palmitoylation and localization status of mBCO2 in the presence of xanthophylls. We created large unilamellar vesicle-based nanocarriers for the successful delivery of xanthophylls into cells. We demonstrate here that, upon treatment with low micromolar concentration of lutein (0.15 µM), mBCO2 is depalmitoylated and shows partial nuclear localization (38.00 ± 0.04%), while treatment with zeaxanthin (0.45 µM) and violaxanthin (0.6 µM) induces depalmitoylation and protein translocation from mitochondria to a lesser degree (20.00 ± 0.01% and 35.00 ± 0.02%, respectively). Such a difference in the behavior of mBCO2 toward various xanthophylls and its translocation into the nucleus in the presence of various xanthophylls suggests a possible mechanism for transport of lutein/lutein cleavage products to the nucleus to affect transcriptional regulation.
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Widomska, Justyna, John Paul SanGiovanni, and Witold K. Subczynski. "Why Is Zeaxanthin the Most Concentrated Xanthophyll in the Central Fovea?" Nutrients 12, no. 5 (May 7, 2020): 1333. http://dx.doi.org/10.3390/nu12051333.
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Diet-based xanthophylls (zeaxanthin and lutein) are conditionally essential polar carotenoids preferentially accreted in high concentrations (1 mM) to the central retina, where they have the capacity to impart unique physiologically significant biophysical biochemical properties implicated in cell function, rescue, and survival. Macular xanthophylls interact with membrane-bound proteins and lipids to absorb/attenuate light energy, modulate oxidative stress and redox balance, and influence signal transduction cascades implicated in the pathophysiology of age-related macular degeneration. There is exclusive transport, sequestration, and appreciable bioamplification of macular xanthophylls from the circulating carotenoid pool to the retina and within the retina to regions required for high-resolution sensory processing. The distribution of diet-based macular xanthophylls and the lutein metabolite meso-zeaxanthin varies considerably by retinal eccentricity. Zeaxanthin concentrations are 2.5-fold higher than lutein in the cone-dense central fovea. This is an ~20-fold increase in the molar ratio relative to eccentric retinal regions with biochemically detectable macular xanthophylls. In this review, we discuss how the differences in the specific properties of lutein and zeaxanthin could help explain the preferential accumulation of zeaxanthin in the most vulnerable region of the macula.
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Giossi, Chiara, Paulo Cartaxana, and Sónia Cruz. "Photoprotective Role of Neoxanthin in Plants and Algae." Molecules 25, no. 20 (October 11, 2020): 4617. http://dx.doi.org/10.3390/molecules25204617.
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Light is a paramount parameter driving photosynthesis. However, excessive irradiance leads to the formation of reactive oxygen species that cause cell damage and hamper the growth of photosynthetic organisms. Xanthophylls are key pigments involved in the photoprotective response of plants and algae to excessive light. Of particular relevance is the operation of xanthophyll cycles (XC) leading to the formation of de-epoxidized molecules with energy dissipating capacities. Neoxanthin, found in plants and algae in two different isomeric forms, is involved in the light stress response at different levels. This xanthophyll is not directly involved in XCs and the molecular mechanisms behind its photoprotective activity are yet to be fully resolved. This review comprehensively addresses the photoprotective role of 9′-cis-neoxanthin, the most abundant neoxanthin isomer, and one of the major xanthophyll components in plants’ photosystems. The light-dependent accumulation of all-trans-neoxanthin in photosynthetic cells was identified exclusively in algae of the order Bryopsidales (Chlorophyta), that lack a functional XC. A putative photoprotective model involving all-trans-neoxanthin is discussed.
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Dreuw, Andreas, Graham R. Fleming, and Martin Head-Gordon. "Chlorophyll fluorescence quenching by xanthophylls." Physical Chemistry Chemical Physics 5, no. 15 (2003): 3247. http://dx.doi.org/10.1039/b304944b.
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Matsuno, T. "Xanthophylls as precursors of retinoids." Pure and Applied Chemistry 63, no. 1 (January 1, 1991): 81–88. http://dx.doi.org/10.1351/pac199163010081.
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BRETILLON, L. "Xanthophylls from blood to retina." Acta Ophthalmologica 88 (September 2010): 0. http://dx.doi.org/10.1111/j.1755-3768.2010.4211.x.
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Demmig-Adams, Barbara, Marina López-Pozo, Jared J. Stewart, and William W. Adams. "Zeaxanthin and Lutein: Photoprotectors, Anti-Inflammatories, and Brain Food." Molecules 25, no. 16 (August 8, 2020): 3607. http://dx.doi.org/10.3390/molecules25163607.
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This review compares and contrasts the role of carotenoids across the taxa of life—with a focus on the xanthophyll zeaxanthin (and its structural isomer lutein) in plants and humans. Xanthophylls’ multiple protective roles are summarized, with attention to the similarities and differences in the roles of zeaxanthin and lutein in plants versus animals, as well as the role of meso-zeaxanthin in humans. Detail is provided on the unique control of zeaxanthin function in photosynthesis, that results in its limited availability in leafy vegetables and the human diet. The question of an optimal dietary antioxidant supply is evaluated in the context of the dual roles of both oxidants and antioxidants, in all vital functions of living organisms, and the profound impact of individual and environmental context.
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Meyer, Monika, and Christian Wilhelm. "Reconstitution of Light-Harvesting Complexes from Chlorella fusca (Chlorophyceae) and Mantoniella squamata (Prasinophyceae)." Zeitschrift für Naturforschung C 48, no. 5-6 (June 1, 1993): 461–73. http://dx.doi.org/10.1515/znc-1993-5-611.
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Abstract Reconstitution experiments of light-harvesting complexes were performed with the green alga Chlorella fusca and the chlorophyll c-containing prasinophyte Mantoniella squamata using a modified method according to Plumley and Schmidt [Proc. N atl. Acad. Sei. U .S.A . 84, 146 -150 (1987)]. Changing the pigment supply quantitatively or qualitatively in the reconstitution mixture homologous and heterologous reconstitutes were obtained. In contrast to higher plants, light-harvesting polypeptides from green algae are able to bind the chlorophylls as well as the xanthophylls in different stoichiometries. Heterologous reconstitutes of M . squamata polypeptides give further evidence for a rather high flexibility of pigment recognition and binding. This is the first report of successful reconstitution of a chlorophyll c-binding protein. Contrary to chlorophyll c-less light-harvesting complexes, the reconstitution of M . squamata is strongly pH-controlled. In summary, the results give evidence for a high specificity of porphyrin ring recognition and variability in xanthophyll binding capacity. Therefore, it is suggested that at least in algal light-harvesting proteins chlorophyll organization may be determined by other mechanisms than xanthophyll binding.
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Yamauchi, Naoki, and Alley E. Watada. "Chlorophyll and Xanthophyll Changes in Broccoli Florets Stored under Elevated CO2 or Ethylene-containing Atmosphere." HortScience 33, no. 1 (February 1998): 114–17. http://dx.doi.org/10.21273/hortsci.33.1.114.
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Chlorophylls and xanthophylls were monitored in broccoli (Brassica oleracea L. var. italica Plen.) florets stored in air, air + 10 ppm ethylene, or 10% CO2 + 1% O2 controlled atmosphere (CA) at 15 °C. Chlorophylls a and b, as measured with high-performance liquid chromatography, decreased in florets held in air. The decrease was accelerated by ethylene treatment and suppressed in CA. Chlorophyllide a and pheophorbide a were present in fresh broccoli florets, but the levels decreased significantly in all treatments during storage. The oxidized product of chlorophyll a, 132-hydroxychlorophyll a, did not accumulate. Xanthophylls decreased, but new pigments, suggested to be esterified xanthophylls, formed with yellowing in stored florets. The chlorophyll degradative pathway in broccoli florets was not altered by ethylene or CA and differed from that reported for parsley (Petroselium crisum Nym.) and spinach (Spinacia oleracea L.) leaves.
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Schweigert, Florian, Andrea Hurtienne, and Katharina Bathe. "Improved Extraction Procedure for Carotenoids from Human Milk." International Journal for Vitamin and Nutrition Research 70, no. 3 (May 1, 2000): 79–83. http://dx.doi.org/10.1024/0300-9831.70.3.79.
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An improved method for the extraction of the major carotenoids from human milk is described. Carotenoids were extracted from milk first with ethanol and n-hexane. Then, polar xanthophylls were extracted from n-hexane into ethanol/water. The remaining n-hexane was evaporated, the residue combined with the ethanolic milk fraction and the mixture briefly saponified. Carotenoids were extracted from the hydrolysate with n-hexane, combined with the polar xanthophylls from the non-saponified ethanol/water-extract and separated by HPLC. Using this method we were able to significantly improve the recovery of xanthophylls such as lutein and zeaxanthin from human milk. The recovery rate of all carotenoids was > 90%. This method might not only be of value for milk but should be especially useful in the extraction of carotenoids from human tissues such as the adipose tissue.
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Smaoui, Slim, Mohamed Barkallah, Hajer Ben Hlima, Imen Fendri, Amin Mousavi Khaneghah, Philippe Michaud, and Slim Abdelkafi. "Microalgae Xanthophylls: From Biosynthesis Pathway and Production Techniques to Encapsulation Development." Foods 10, no. 11 (November 17, 2021): 2835. http://dx.doi.org/10.3390/foods10112835.
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In the last 20 years, xanthophylls from microalgae have gained increased scientific and industrial interests. This review highlights the essential issues that concern this class of high value compounds. Firstly, their chemical diversity as the producer microorganisms was detailed. Then, the use of conventional and innovative extraction techniques was discussed. Upgraded knowledge on the biosynthetic pathway of the main xanthophylls produced by photosynthetic microorganisms was reviewed in depth, providing new insightful ideas, clarifying the function of these active biomolecules. In addition, the recent advances in encapsulation techniques of astaxanthin and fucoxanthin, such as spray and freeze drying, gelation, emulsification and coacervation were updated. Providing information about these topics and their applications and advances could be a help to students and young researchers who are interested in chemical and metabolic engineering, chemistry and natural products communities to approach the complex thematic of xanthophylls.
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Tudor, Cristina, Torsten Bohn, Mohammed Iddir, Francisc Vasile Dulf, Monica Focşan, Dumitriţa Olivia Rugină, and Adela Pintea. "Sea Buckthorn Oil as a Valuable Source of Bioaccessible Xanthophylls." Nutrients 12, no. 1 (December 27, 2019): 76. http://dx.doi.org/10.3390/nu12010076.
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Sea buckthorn oil, derived from the fruits of the shrub, also termed seaberry or sandthorn, is without doubt a strikingly rich source of carotenoids, in particular zeaxanthin and β-carotene. In the present study, sea buckthorn oil and an oil-in-water emulsion were subjected to a simulated gastro-intestinal in vitro digestion, with the main focus on xanthophyll bioaccessibility. Zeaxanthin mono- and di-esters were the predominant carotenoids in sea buckthorn oil, with zeaxanthin dipalmitate as the major compound (38.0%). A typical fatty acid profile was found, with palmitic (49.4%), palmitoleic (28.0%), and oleic (11.7%) acids as the dominant fatty acids. Taking into account the high amount of carotenoid esters present in sea buckthorn oil, the use of cholesterol esterase was included in the in vitro digestion protocol. Total carotenoid bioaccessibility was higher for the oil-in-water emulsion (22.5%) compared to sea buckthorn oil (18.0%) and even higher upon the addition of cholesterol esterase (28.0% and 21.2%, respectively). In the case of sea buckthorn oil, of all the free carotenoids, zeaxanthin had the highest bioaccessibility (61.5%), followed by lutein (48.9%), making sea buckthorn oil a potential attractive source of bioaccessible xanthophylls.
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Betke, Alexander, and Heiko Lokstein. "Two-photon excitation spectroscopy of photosynthetic light-harvesting complexes and pigments." Faraday Discussions 216 (2019): 494–506. http://dx.doi.org/10.1039/c8fd00198g.
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Two-photon excitation (TPE) profiles of LHCII samples containing different xanthophyll complements were measured in the presumed 11Ag− → 21Ag− (S0 → S1) transition region of xanthophylls. Additionally, TPE profiles of Chls a and b in solution and of WSCP, which does not contain carotenoids, were measured. The results indicate that direct two-photon absorption by Chls in the presumed S0 → S1 transition spectral region of carotenoids is dominant over that of carotenoids, with negligible contributions of the latter. These results suggest the re-evaluation of previously published TPE data obtained with photosynthetic pigment–protein complexes containing (B)Chls and carotenoids.
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Hughes, Kathryn J., Susan T. Mayne, Jeffrey B. Blumberg, Judy D. Ribaya-Mercado, Elizabeth J. Johnson, and Brenda Cartmel. "Plasma Carotenoids and Biomarkers of Oxidative Stress in Patients with prior Head and Neck Cancer." Biomarker Insights 4 (January 2009): BMI.S2192. http://dx.doi.org/10.4137/bmi.s2192.
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Diets high in fruits and vegetables are generally believed protective against several chronic diseases. One suggested mechanism is a reduction in oxidative stress. The carotenoids, nutrients found in colored fruits and vegetables, possess antioxidant properties in vitro, but their role in humans is less well documented. The aim of this cross-sectional study was to explore the relationships between the most abundant plasma carotenoids (alpha-carotene, beta-carotene, lycopene, lutein, zeaxanthin and beta-cryptoxanthin), as well as grouped carotenoids (total xanthophylls, carotenes and carotenoids), and urinary excretion of the F2-isoprostanes (F2-IsoPs), stable and specific biomarkers of oxidative damage to lipids. Two F2-IsoP measures were utilized: total F2-IsoPs and 8-iso-PGF2α. The study population (N = 52) was drawn from a study among patients curatively treated for early-stage head and neck cancer. Unadjusted linear regression analyses revealed significant inverse associations between plasma lutein, total xanthophylls and both F2-IsoP measures at baseline. After control for potential confounders, all individual and grouped xanthophylls remained inversely associated with the F2-IsoP measures, but none of these associations achieved significance. The carotenes were not inversely associated with total F2-IsoPs or 8-iso-PGF2a concentrations. The finding of consistent inverse associations between individual and grouped xanthophylls, but not individual and grouped carotenes, and F2-IsoPs is intriguing and warrants further investigation.
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Miller, Nicholas J., Julia Sampson, Luis P. Candeias, Peter M. Bramley, and Catherine A. Rice-Evans. "Antioxidant activities of carotenes and xanthophylls." FEBS Letters 384, no. 3 (April 22, 1996): 240–42. http://dx.doi.org/10.1016/0014-5793(96)00323-7.
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Gruszecki, Wiesław I., and Jan Sielewiesiuk. "Orientation of xanthophylls in phosphatidylcholine multibilayers." Biochimica et Biophysica Acta (BBA) - Biomembranes 1023, no. 3 (April 1990): 405–12. http://dx.doi.org/10.1016/0005-2736(90)90133-9.
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Cvetkovic, Dragan, and Dejan Markovic. "Stability of carotenoids toward UV-irradiation in hexane solution." Journal of the Serbian Chemical Society 73, no. 1 (2008): 15–27. http://dx.doi.org/10.2298/jsc0801015c.
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The stabilities of four selected carotenoids dissolved in hexane, two carotenes and two xanthophylls, toward UV-irradiation of three different ranges (UV-A, UV-B and UV-C) were studied in this work. The carotenoids underwent bleaching via a probable free radical mediated mechanism following first-order kinetics. The bleaching rates were highly dependent on the input of the involved photons and, although not consistently, on the chemical structures of the investigated compounds. For the two xanthophylls, a possible role of oxygen associated with their bleaching cannot be neglected.
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Ficek, S., and S. Więckowski. "The effect of chloramphenicol, actinomycin D and 5-bromouracil on the synthesis of photosynthetic pigments." Acta Societatis Botanicorum Poloniae 43, no. 2 (2015): 251–59. http://dx.doi.org/10.5586/asbp.1974.024.
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The present study concerned the effect of chloramphenicol (100 μg/ml), actinomycin D (30 μg/ml), and 5-bromouracil (190 μg/ml) on the accumulation of chlorophyll α, chlorophyll b, β-carotene and four fractions of xanthophylls (with the domination of: lutein, zeaxanthin, violaxanthin and neoxanthin) in the primary bean leaves. The pigment content was determined in etiolated leaves after exposure to light for different lengths of time. It results from this study that chloramphenicol inhibits β-carotene synthesis more than do other pigments. The formation of xanthophylls and chlorophyll b is relatively less sensitive to the action of this antibiotic. Actinomycin D is also a somewhat more effective inhibitor of the accumulation of β-carotene than other pigments. In 5-bromouracil-treated leaves the accumulation of all carotenoids is inhibited almost to the same extent. These results suggest that the accumulation of chlorophyll b and xanthophylls is a little less dependent upon the activity of 70 S ribosomes in chloroplasts than the accumulation of chlorophyll α and β-carotene.
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Karpiński, Tomasz M., Marek Kwaśniewski, Marcin Ożarowski, and Rahat Alam. "In silico studies of selected xanthophylls as potential candidates against SARS-CoV-2 targeting main protease (Mpro) and papain-like protease (PLpro)." Herba Polonica 67, no. 2 (June 1, 2021): 1–8. http://dx.doi.org/10.2478/hepo-2021-0009.
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Summary Introduction: The main protease (Mpro) and the papain-like protease (PLpro) are essential for the replication of SARS-CoV-2. Both proteases can be targets for drugs acting against SARS-CoV-2. Objective: This paper aims to investigate the in silico activity of nine xanthophylls as inhibitors of Mpro and PLpro. Methods: The structures of Mpro (PDB-ID: 6LU7) and PLpro (PDB-ID: 6W9C) were obtained from RCSB Protein Data Bank and developed with BIOVIA Discovery Studio. Active sites of proteins were performed using CASTp. For docking the PyRx was used. Pharmacokinetic parameters of ADMET were evaluated using SwissADME and pkCSM. Results: β-cryptoxanthin exhibited the highest binding energy: –7.4 kcal/mol in the active site of Mpro. In PLpro active site, the highest binding energy had canthaxanthin of –9.4 kcal/mol, astaxanthin –9.3 kcal/mol, flavoxanthin –9.2 kcal/mol and violaxanthin –9.2 kcal/mol. ADMET studies presented lower toxicity of xanthophylls in comparison to ritonavir and ivermectin. Conclusion: Our findings suggest that xanthophylls can be used as potential inhibitors against SARS-CoV-2 main protease and papain-like protease.
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Moreno, Karla J., María Teresa Hernández-Sierra, José E. Báez, Eloy Rodríguez-deLeón, Luis Daniel Aguilera-Camacho, and J. Santos García-Miranda. "On the Tribological and Oxidation Study of Xanthophylls as Natural Additives in Castor Oil for Green Lubrication." Materials 14, no. 18 (September 19, 2021): 5431. http://dx.doi.org/10.3390/ma14185431.
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The present study focuses on an introductory analysis of the use of three xanthophylls as additives for green lubricant applications. For this purpose, the additives were characterized by FTIR and 1H-NMR techniques, and the bio-lubricants were described by their physical properties. The effect of the natural compounds on the friction and wear properties of bio-lubricants were evaluated by sliding friction tests under boundary conditions, as confirmed by an analysis of the lubricating film thickness. The antioxidant capacity was analyzed by FTIR spectroscopy. It was observed better wear protection in castor oil with xanthophylls than without these additives. The wear rate was reduced up to 50% compared with neat oil. Lesser beneficial effects were appreciated in friction coefficient since it was increased 25%. The best contribution was observed with astaxanthin as an additive. In addition, a significant improvement in the oxidation of castor oil, complemented with this additive, was exhibited by FTIR analysis. It was found that xanthophylls could be employed as additives for totally biodegradable lubricant applications since they have better tribological and antioxidant behavior than current additives.
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Prasanthi, P. S., M. Vishnuvardhana Rao, and Bhaskarachary K. "Retention of Xanthophylls in Green Foliar Vegetables after Different Food Preparations." Indian Journal of Nutrition and Dietetics 55, no. 3 (July 5, 2018): 241. http://dx.doi.org/10.21048/ijnd.2018.55.3.21081.
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Green leafy vegetables (GLV) are rich sources of micronutrients, which have many health benefits and have the potential to combat the problem of malnutrition. However, domestic processing and cooking alter the nutrient contents. To study the retention of xanthophylls after processing, ten different GLV which are commonly available and regularly consumed, were analysed for total carotenoids, lutein, zeaxanthin and violaxanthin in both raw and cooked forms. In the unprocessed GLV, the lutein content on dry basis ranged from 341 mg/kg in Murraya koenigii to 959 mg/kg in Spinacia oleracea while zeaxanthin ranged from traces in Coriandrum sativum and Rumex acetosa to 15.45 mg/kg in Basella alba. In the case of violaxanthin, while it was not detectable in Hibiscus cannabinus, Amaranthus viridis had 794 mg/kg. The total carotenoids, lutein, zeaxanthin and violaxanthin in the processed GLV varied based on the variety of leafy vegetable cooked and the method of cooking. Microwave cooking followed by steaming were the most recommended method, while deep frying drastically reduced the total carotenoids and xanthophyll content followed by sautéing with oil. Overall, different methods of cooking resulted in changes in the phytochemical composition which are due to various factors such as leaf matrix, cooking method, cooking time and temperature.
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Tyssandier, Viviane, Georges Choubert, Pascal Grolier, and Patrick Borel. "Carotenoids, Mostly the Xanthophylls, Exchange Between Plasma Lipoproteins." International Journal for Vitamin and Nutrition Research 72, no. 5 (October 1, 2002): 300–308. http://dx.doi.org/10.1024/0300-9831.72.5.300.
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Carotenoids are exclusively transported by lipoproteins; in vitro studies suggest that they might protect these particles against oxidation. Little is known about the factors that govern the distribution of these micronutrients among lipoproteins. The objective of this study was to assess whether carotenoids are exchanged between lipoproteins and what factors, if any, were involved. In the first experiment, different groups of trout were fed for five days with either a carotenoid-free diet or with diets containing 80 mg pure carotenoid per kilogram of feed. Lipoproteins were separated by ultracentrifugation and carotenoid-rich, high-density lipoproteins (HDL) were incubated for two hours at 37°C with carotenoid-free, very low-density lipoproteins (VLDL), and vice versa. After incubation, lipoproteins were re-separated and carotenoids were quantified to measure the transfer. The same experiments were done in the presence of cholesteryl ester transfer protein (CETP) and lecithin cholesterol acyltransferase (LCAT) inhibitors. In a second experiment, the exchange was measured between human VLDL and HDL. In trout, incubation of carotenoid-rich HDL with carotenoid-free VLDL resulted in the appearance of carotenoids in VLDL, and inversely. The higher the hydrophobicity of a carotenoid, the lower its proportion in HDL after incubation. CETP and LCAT inhibitors significantly increased the proportion of carotenoids in HDL after incubation. Results obtained with human lipoproteins showed that the xanthophyll lutein transferred between lipoproteins, but could not show any carotenes (alpha-carotene, beta-carotene, and lycopene) transfer. We conclude that carotenoids, chiefly the xanthophylls, exchange between lipoproteins. The transfer depends on plasma factor(s) sensitive to CETP and/or LCAT inhibitors.
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Proctor, Matthew S., Marek Pazderník, Philip J. Jackson, Jan Pilný, Elizabeth C. Martin, Mark J. Dickman, Daniel P. Canniffe, et al. "Xanthophyll carotenoids stabilise the association of cyanobacterial chlorophyll synthase with the LHC-like protein HliD." Biochemical Journal 477, no. 20 (October 29, 2020): 4021–36. http://dx.doi.org/10.1042/bcj20200561.
Full textAbstract:
Chlorophyll synthase (ChlG) catalyses a terminal reaction in the chlorophyll biosynthesis pathway, attachment of phytol or geranylgeraniol to the C17 propionate of chlorophyllide. Cyanobacterial ChlG forms a stable complex with high light-inducible protein D (HliD), a small single-helix protein homologous to the third transmembrane helix of plant light-harvesting complexes (LHCs). The ChlG–HliD assembly binds chlorophyll, β-carotene, zeaxanthin and myxoxanthophyll and associates with the YidC insertase, most likely to facilitate incorporation of chlorophyll into translated photosystem apoproteins. HliD independently coordinates chlorophyll and β-carotene but the role of the xanthophylls, which appear to be exclusive to the core ChlG–HliD assembly, is unclear. Here we generated mutants of Synechocystis sp. PCC 6803 lacking specific combinations of carotenoids or HliD in a background with FLAG- or His-tagged ChlG. Immunoprecipitation experiments and analysis of isolated membranes demonstrate that the absence of zeaxanthin and myxoxanthophyll significantly weakens the interaction between HliD and ChlG. ChlG alone does not bind carotenoids and accumulation of the chlorophyllide substrate in the absence of xanthophylls indicates that activity/stability of the ‘naked’ enzyme is perturbed. In contrast, the interaction of HliD with a second partner, the photosystem II assembly factor Ycf39, is preserved in the absence of xanthophylls. We propose that xanthophylls are required for the stable association of ChlG and HliD, acting as a ‘molecular glue’ at the lateral transmembrane interface between these proteins; roles for zeaxanthin and myxoxanthophyll in ChlG–HliD complexation are discussed, as well as the possible presence of similar complexes between LHC-like proteins and chlorophyll biosynthesis enzymes in plants.
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Sheftel, Jesse, Bryan M. Gannon, Christopher R. Davis, and Sherry A. Tanumihardjo. "Provitamin A-biofortified maize consumption increases serum xanthophylls and 13C-natural abundance of retinol in Zambian children." Experimental Biology and Medicine 242, no. 15 (August 24, 2017): 1508–14. http://dx.doi.org/10.1177/1535370217728500.
Full textAbstract:
Plants that undergo C4 photosynthesis, such as maize, are enriched in the stable isotope of carbon (13C) compared with other dietary plants and foods. Consumption of maize that has been biofortified to contain elevated levels of provitamin A carotenoids (orange maize) increased the abundance of 13C in serum retinol of Mongolian gerbils. We evaluated this method in humans to determine if it has potential for further use in intervention effectiveness studies. A random subset of samples from a two-month randomized controlled feeding trial of rural three- to five-year old Zambian children were used to determine the impact of orange maize intake on serum carotenoid concentrations ( n = 88) and 13C-natural abundance in serum retinol ( n = 77). Concentrations of β-cryptoxanthin (a xanthophyll provitamin A carotenoid) and the dihydroxy xanthophylls lutein and zeaxanthin, which do not have vitamin A activity, were elevated in children consuming orange maize compared with those consuming a white maize control ( P < 0.001), while β-carotene was not different ( P > 0.3). Furthermore, 13C natural abundance was higher after two months’ intervention in the orange maize group compared with the white maize group ( P = 0.049). Predictions made from equations developed in the aforementioned gerbil study estimated that maize provided 11% (2–21%, 95% confidence interval) of the recent dietary vitamin A to these children. These results demonstrate that orange maize is efficacious at providing retinol to the vitamin A pool in children through provitamin A carotenoids, as monitored by the change in 13C enrichment, which was not reflected in serum β-carotene concentrations. Further effectiveness studies in countries who have adopted orange maize should consider determining differences in retinol 13C-enrichment among target groups in addition to profiling serum xanthophyll carotenoids with specific emphasis on zeaxanthin. Impact statement Maize biofortified with provitamin A carotenoids (orange) has been released in some African markets. Responsive and sensitive methods to evaluate dissemination effectiveness are needed. This study investigated methods to evaluate effectiveness of orange maize consumption using serum from Zambian children fed orange maize for two months. Many varieties of orange maize contain higher amounts of the xanthophyll carotenoids in addition to β-carotene compared with typical varieties. This study uniquely showed higher concentrations of the maize xanthophylls lutein, zeaxanthin, and β-cryptoxanthin in children who consumed orange maize compared with white. Furthermore, maize is a C4 plant and is therefore naturally enriched with 13C. Higher 13C was detected in the serum retinol of the orange maize consumers with no change in serum β-carotene concentration suggesting preferential bioconversion to retinol. The combined analyses of serum zeaxanthin specifically and 13C-natural abundance of retinol could prove useful in effectiveness studies between orange maize adopters and non-adopters.