Relevant bibliographies by topics / Xanthines

Academic literature on the topic 'Xanthines'

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Published: 4 June 2021
Last updated: 7 September 2023

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Journal articles on the topic "Xanthines"

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Inamoto, Kiyofumi, Maki Shimizu, Noboru Hayama, and Tetsutaro Kimachi. "Copper-Catalyzed Intramolecular C–H Amination: A New Entry to Substituted Xanthine Derivatives." Synthesis 49, no. 18 (May 9, 2017): 4183–90. http://dx.doi.org/10.1055/s-0036-1588821.

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Catalytic synthesis of xanthines was achieved in the presence of a copper catalyst. The process involves copper-catalyzed intramolecular C–H amination of benzamidines that possess a uracil moiety and produces variously substituted xanthines generally in good to high yields. This work introduces a new, facile approach to polysubstituted xanthine compounds.
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Woziwodzka, Anna, Marta Krychowiak-Maśnicka, Grzegorz Gołuński, Anna Felberg, Agnieszka Borowik, Dariusz Wyrzykowski, and Jacek Piosik. "Modulatory Effects of Caffeine and Pentoxifylline on Aromatic Antibiotics: A Role for Hetero-Complex Formation." Molecules 26, no. 12 (June 14, 2021): 3628. http://dx.doi.org/10.3390/molecules26123628.

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Antimicrobial resistance is a major healthcare threat globally. Xanthines, including caffeine and pentoxifylline, are attractive candidates for drug repurposing, given their well-established safety and pharmacological profiles. This study aimed to analyze potential interactions between xanthines and aromatic antibiotics (i.e., tetracycline and ciprofloxacin), and their impact on antibiotic antibacterial activity. UV-vis spectroscopy, statistical-thermodynamical modeling, and isothermal titration calorimetry were used to quantitatively evaluate xanthine-antibiotic interactions. The antibacterial profiles of xanthines, and xanthine-antibiotic mixtures, towards important human pathogens Staphylococcus aureus, Enterococcus faecium, Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae, and Enterobacter cloacae were examined. Caffeine and pentoxifylline directly interact with ciprofloxacin and tetracycline, with neighborhood association constant values of 15.8–45.6 M−1 and enthalpy change values up to −4 kJ·M−1. Caffeine, used in mixtures with tested antibiotics, enhanced their antibacterial activity in most pathogens tested. However, antagonistic effects of caffeine were also observed, but only with ciprofloxacin toward Gram-positive pathogens. Xanthines interact with aromatic antibiotics at the molecular and in vitro antibacterial activity level. Given considerable exposure to caffeine and pentoxifylline, these interactions might be relevant for the effectiveness of antibacterial pharmacotherapy, and may help to identify optimal treatment regimens in the era of multidrug resistance.
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&NA;. "Xanthines see Ephedrine/xanthines." Reactions Weekly &NA;, no. 337 (February 1991): 8. http://dx.doi.org/10.2165/00128415-199103370-00055.

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&NA;. "Xanthines." Reactions Weekly &NA;, no. 307 (June 1990): 8. http://dx.doi.org/10.2165/00128415-199003070-00041.

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Gibson, Christopher M., and Patrick W. Fowler. "Aromaticity of caffeine, xanthine and the dimethyl xanthines." Tetrahedron Letters 55, no. 13 (March 2014): 2078–81. http://dx.doi.org/10.1016/j.tetlet.2014.02.027.

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6

Aleksandrova, K. V., Ye S. Pruhlo, Ye K. Mykhalchenko, O. S. Shkoda, and O. Yu Cherchesova. "Search for potential hypoglycemic agents among potassium salts of 3-benzyl-8-substituted xanthines." Current issues in pharmacy and medicine: science and practice 15, no. 3 (November 15, 2022): 266–70. http://dx.doi.org/10.14739/2409-2932.2022.3.253385.

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Nowadays, the prevalence of metabolic syndrome (MS) is a serious problem among the world’s population. Metabolic syndrome includes the so-called “deadly” quartet – hypertension, type 2 diabetes mellitus (diabetes mellitus), dyslipidemia and alimentary obesity. After all, type 2 diabetes is included in the list of pathologies of the metabolic syndrome, it is important to find ways to alleviate the disease. Derivatives of such a heterocyclic system as xanthine are of great interest in this aspect. The aim of the study was to explore the hypoglycemic activity of newly synthesized water-soluble derivatives of 3-benzyl-8-substituted xanthines. Materials and methods. We obtained water-soluble potassium 3-benzyl-8-R-xanthin-7-ides, the structure and individuality of which were confirmed by a set of physical-chemical studies. Results. The hypoglycemic effect of the newly synthesized compounds was assessed by an oral glucose tolerance test. The obtained data were processed using modern statistical in silico-methods. Conclusions. The results of the hypoglycemic activity study among the potassium salts of 3-benzyl-8-substituted xanthine derivatives showed, that some new compounds are in close vicinity to the reference drug’s hypoglycemic action.
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Sánchez-Eleuterio, Alma, Carlos Mendoza-Merlos, Ricardo Corona Sánchez, Alejandra M. Navarrete-López, Anatolio Martínez Jiménez, Elsie Ramírez-Domínguez, Leticia Lomas Romero, Ricardo Orozco Cruz, Araceli Espinoza Vázquez, and Guillermo E. Negrón-Silva. "Experimental and Theoretical Studies on Acid Corrosion Inhibition of API 5L X70 Steel with Novel 1-N-α-d-Glucopyranosyl-1H-1,2,3-Triazole Xanthines." Molecules 28, no. 1 (January 3, 2023): 460. http://dx.doi.org/10.3390/molecules28010460.

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A series of novel 1-N-α-d-glucopyranosyl-1H-1,2,3-triazole xanthines was synthesized from azido sugars (glucose, galactose, and lactose) and propargyl xanthines (theophylline and theobromine) using a typical copper (I)-catalyzed azide–alkyne 1,3-dipolar cycloaddition. The corrosion inhibition activities of these new carbohydrate-xanthine compounds were evaluated by studying the corrosion of API 5 L X70 steel in a 1 M HCl medium. The results showed that, at 10 ppm, a 90% inhibition efficiency was reached by electrochemical impedance spectroscopy. The inhibitory efficiency of these molecules is explained by means of quantum chemical calculations of the protonated species with the solvent effect, which seems to better represent the actual situation of the experimental conditions. Some quantum chemical parameters were analyzed to characterize the inhibition performance of the tested molecules.
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&NA;. "Theophylline/xanthines." Reactions Weekly &NA;, no. 403 (May 1992): 8. http://dx.doi.org/10.2165/00128415-199204030-00031.

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&NA;. "Ephedrine/xanthines." Reactions Weekly &NA;, no. 337 (February 1991): 5. http://dx.doi.org/10.2165/00128415-199103370-00027.

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10

Cazzola, Mario, Luigino Calzetta, Peter J. Barnes, Gerard J. Criner, Fernando J. Martinez, Alberto Papi, and Maria Gabriella Matera. "Efficacy and safety profile of xanthines in COPD: a network meta-analysis." European Respiratory Review 27, no. 148 (May 2, 2018): 180010. http://dx.doi.org/10.1183/16000617.0010-2018.

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Theophylline can still have a role in the management of stable chronic obstructive pulmonary disease (COPD), but its use remains controversial, mainly due to its narrow therapeutic window. Doxofylline, another xanthine, is an effective bronchodilator and displays a better safety profile than theophylline. Therefore, we performed a quantitative synthesis to compare the efficacy and safety profile of different xanthines in COPD.The primary end-point of this meta-analysis was the impact of xanthines on lung function. In addition, we assessed the risk of adverse events by normalising data on safety as a function of person-weeks. Data obtained from 998 COPD patients were selected from 14 studies and meta-analysed using a network approach.The combined surface under the cumulative ranking curve (SUCRA) analysis of efficacy (change from baseline in forced expiratory volume in 1 s) and safety (risk of adverse events) showed that doxofylline was superior to aminophylline (comparable efficacy and significantly better safety), bamiphylline (significantly better efficacy and comparable safety), and theophylline (comparable efficacy and significantly better safety).Considering the overall efficacy/safety profile of the investigated agents, the results of this quantitative synthesis suggest that doxofylline seems to be the best xanthine for the treatment of COPD.
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Dissertations / Theses on the topic "Xanthines"

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Riche, Christian. "Xanthines : approches analytique, clinique, métabolique." Besançon, 1988. http://www.theses.fr/1988BESAA001.

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A partir de techniques de dosage des bases xanthiques par chromatographie en phase gazeuse, sur colonne capillaire de verre, avec détection thermoionique, et par chromatographie liquide de haute performance sur colonne C18, utilisant un gradient de solvant, sont abordés des problèmes de pharmacologie clinique et de métabolisme in vivo et in vitro. L'utilisation de la théophylline et de la caféine dans le cadre du traitement des apnées du nouveau-né est étudiée. Deux expérimentations cliniques, destinées à déterminer la zone thérapeutique de la théophylline et de la caféine sont rapportées. Le seuil minimal d'effecacité a été trouvé à 3 mg/l (17µmol/l) pour la théophylline et à 12 mg/l (63 µmol/l) pour la caféine. Pour la théophylline, le seuil de toxicité est de 8 mg/l (44µmol/l) et 20 mg/l (100 µmol/l) pour la caféine. Ce travail est complété par une approche du métabolisme in vitro, à l'aide d'hépatocytes en culture primaire d'homme adulte et de nouveau-né, en comparaison avec des résultats observés avec des hépatocytes de rat. Une transformation de la théophylline en caféine par les hépatocytes d'adulte a été mise en évidence. Le métabolisme du nouveau-né est limité. Pour la caféine chez l'adulte, on retrouve qualitativement et quantitativement les mêmes schémas métaboliques in vitro et in vivo, en ce qui concerne les déméthylations. D'autre part, il existe une différence importante entre espèces. Le modèle in vitro permet une bonne extrapolation de ce qui est connu in vivo.
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Perticarari, Sofia. "Atropisomeric xanthines: Synthesis, stereodynamics and absolute configuration." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/9025/.

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During the thesis period a new class of atropisomeric xanthine derivatives has been studied. We decided to focus our attention on these purine bases because of their various biological activities, that could play an important role in the discovery of new bioactive atropisomers. The synthesized compounds bear an Aryl-N chiral axis in position 1 of the xanthine scaffold, around which the rotation is prevented by the presence of bulky ortho substituents. Through a retro synthetic analysis we synthesized three atropisomeric structures bearing in position 1 of the purine scaffold respectively an o-tolyl, o-nitrophenyl and a 1-naphthyl group. The conformational studies by DFT simulations showed that the interconversion energy barrier between the two available skewed conformations is higher enough to obtain thermally stable atropisomers. After the separation of the atropisomers, the experimental energy of interconversion was investigated by means of kinetic studies following the thermal racemization process using an enantioselective HPLC column. The absolute configuration of each atropisomer was assigned by experimental ECD analysis and TD-DFT simulations of the ECD spectra.
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Beauglehole, Anthony Robert, and anthony@adenrx com. "N3-substituted xanthines as irreversible adenosine receptor antagonists." Deakin University. School of Biological and Chemical Sciences, 2000. http://tux.lib.deakin.edu.au./adt-VDU/public/adt-VDU20080612.084330.

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8-Cyclopentyl-3-(3-(4-fluorosulfonylbenzoyl)oxy)propyl-propylxanthine (44, FSCPX) has been reported to exhibit potent and selective irreversible antagonism of the A1 adenosine receptor when using in vitro biological preparations. However, FSCPX (44) suffers from cleavage of the ester linkage separating the reactive 4-(fluorosulfonyl)phenyl moiety from the xanthine pharmacophore when used in in vivo biological preparations or preparations containing significant enzyme activity, presumably by esterases. Cleavage of the ester linkage renders FSCPX (44) inactive in terms of irreversible receptor binding. In order to obtain an irreversible A1 adenosine receptor antagonist with improved stability, and to further elucidate the effects of linker structure on pharmacological characteristics, several FSCPX (44) analogues incorporating the chemoreactive 4-(fluorosulfonyl)phenyl moiety were targeted, where the labile ester linkage has been replaced by more stable functionalites. In particular, ether, alkyl, amide and ketone linkers were targeted, where the length of the alkyl chain was varied from between one to five atoms. Synthesis of the target compounds was achieved via direct attachment of the N-3 substituent to the xanthine. These compounds were then tested for their biological activity at the A1 adenosine receptor via their ability to irreversibly antagonise the binding of [3H]-8-cyclopentyl-1,3-dipropylxanthine ([3H]DPCPX, ( 9) to the A1 adenosine receptor of DDT1 MF-2 cells. For comparison, the xanthines were also tested for their ability to inhibit the binding of [3H]-4-(2-[7-amino-2-{furyl} {1,2,4}- triazolo{2,3-a} {1,3,5}triazin-5-ylamino-ethyl)]phenol ([3H]ZM241385, 36) to the A2A adenosine receptor of PC-12 cells. The results suggest that the length and chemical composition of the linker separating the reactive 4-(fluorosulfonyl)phenyl moiety from the xanthine ring contribute to the potency and efficacy of the irreversible A1 adenosine receptor ligands. Like FSCPX (44, IC50 A1 = 11.8 nM), all derivatives possessed IC50 values in the low nM range under in vitro conditions. Compounds 94 (IC50 A1 = 165 nM), 95 (IC50 A1 = 112 nM) and 96 (IC50 A1 = 101 nM) possessing one, three and five methylene spacers within the linkage respectively, exhibited potent and selective binding to the A1 adenosine receptor versus the A2A adenosine receptor. Compound 94 did not exhibit any irreversible binding at A1 adenosine receptors, while 95 and 96 exhibit only weak irreversible binding at A1 adenosine receptors. Those compounds containing a benzylic carbonyl separating the 4-(fluorosulfonyl)phenyl moiety from the xanthine ring in the form of an amide (119, IC50 A1 = 24.9 nM, and 120, IC50 A1 = 21 nM) or ketone (151, IC50 A1 = 14 nM) proved to be the most potent, with compound 120 exhibiting the highest selectivity of 132-fold for the A receptor over the A2A receptor. compounds 119, 120 and 151 also strongly inhibited the binding of [3H]DPCPX irreversibly (82%, 83% and 78% loss of [3H]DPCPX binding at 100 nM respectively). compounds 120 and 151 are currently being evaluated for use in in vivo studies. Structure-activity studies suggest that altering the 8-cycloalkyl group of A1 selective xanthines for a 3-substituted or 2,3-disubstituted styryl, combined with N-7 methyl substitution will produce a compound with high affinity and selectivity for the A2A adenosine receptor over the A1 adenosine receptor. Compound 167 (IC50 A2A = 264 nM) possessing 8-(m-chloro)styryl substitution and the reactive 4-(fluorosulfonyl)phenyl moiety separated from the xanthine ring via an amide linker in the 3-position (as for 119 and 120), exhibited relatively potent binding to the A2A adenosine receptor of PC-12 cells, with a 16-fold selectivity for that receptor over the A1 adenosine receptor. However, compound 167 exhibited only very weak irreversible binding at A2A adenosine receptors. Overall, at this stage of biological testing, compound 120 appears to possess the most advantageous characteristics as an irreversible antagonist for the A1 adenosine receptor. This can be attributed to its high selectivity for the A1 adenosine receptor as compared to the A2A adenosine receptor. It also has relatively high potency for the A1 adenosine receptor, a concentration-dependent and selective inactivation of A1 adenosine receptors, and unbound ligand is easily removed (washed out) from biological membranes. These characteristics mean compound 151 has the potential to be a useful tool for the further study of the structure and function of the A1 adenosine receptor.
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Duckworth, Megan Jane Medical Sciences Faculty of Medicine UNSW. "Characterisation of the xanthineguanine phosphoribosyltransferase of helicobacter pylori as a potential therapeutic target." Publisher:University of New South Wales. Medical Sciences, 2008. http://handle.unsw.edu.au/1959.4/43418.

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Helicobacter pylori infects more than half of the global population and causes gastric disorders. The increasing development of antibiotic resistance by the bacterium continues to limit treatment options. The identification and characterisation of novel therapeutic targets are necessary for successful future treatment of the infection. One potential target for therapeutic intervention is the gpt gene encoded by hp0735 (jhp0672) in H. pylori strain 26695 (J99). This gene produces a putative xanthine-guanine phosphoribosyltransferase (XGPRTase), an enzyme of the purine salvage synthesis pathway. This project employed theoretical, molecular and biochemical approaches to investigate features of H. pylori gpt and XGPRTase that will serve to ascertain their therapeutic potential. The production of a functional XGPRTase by H. pylori was investigated in cell-free extracts, and the kinetic parameters of this activity were compared to those of purified rXGPRTase enzyme. The three 6-oxopurine substrates were recognised by rXGPRTase and allosteric kinetics were observed for some substrates of the enzyme in cell-free extracts and for purified enzyme. These observations indicate complex regulation and an influence of cellular interactions on activity. Bioinformatics were employed to analyse XGPRTase phylogeny, and threading techniques used to build a structural model of XGPRTase. The enzyme is significantly divergent from the equivalent mammalian enzyme, and modelling identified specific features of the enzyme. Molecular approaches were utilised to analyse the essential role of gpt in H. pylori survival. These included insertional inactivation of the gpt in wild-type H. pylori strains and in mutants possessing a complementing copy of the gene present at the rdxA locus. No mutants were recovered with inactivated gpt possibly as a result of pleiotropic effects. Plasmid-mediated complementation was attempted employing IPTG-inducible shuttle vectors and did not yield any mutants. Further characterisation of H. pylori XGPRTase was performed by determining the effects of nucleotide monophosphates and purine analogues on enzyme activity. Inhibition by GMP was observed in all cases, however differences in the inhibition by other nucleotide monophosphates were found between cell-free extracts and the recombinant enzyme. Inhibition of rXGPRTase activity was observed by the purine analogue 6-mercaptopurine ribose, a compound that previously has been shown to inhibit H. pylori growth in culture.
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Kascatan, Nebioglu Aysegul. "N-HETEROCYCLIC CARBENE SILVER(I) COMPLEXES FROM XANTHINES AND THEIR ANTIMICROBIAL APPLICATIONS." University of Akron / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=akron1176579309.

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Massip, Stéphane. "Synthèse de nouvelles xanthines, dérivées de 2-amino-2-oxazolines, antagonistes potentiels des récepteurs de l'adenosine." Bordeaux 2, 2005. http://www.theses.fr/2005BOR21206.

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Ce travail de thèse nous a permis de synthétiser un grand nombre de nouveaux dérivés de type 1- ou 3-[2-hydroxy-3-aryloxypropyl]xanthines. Ces composés ont été obtenus à partir d'un synthon original de type amidine, les 2-amino-2-oxazolines. Les différentes voies réaxtionnelles nous ont conduit à des diaminouraciles intermédiaires diversement substitués dont les possibilités réactionnelles nous ont permis l'accès à plus de 60 nouvelles xanthines et analogues. Différentes stratégies de synthèse ont été développées pour accéder à de nouvelles xanthines 3 différemment substituées en position 1 et 7. L'ensemble de ces composés originaux a fait l'objet d'études de liaison en tant qu'antagonistes potentiels vis-vis des récepteurs de l'adénosine. Ces tests ont pu êttre réalisés grâce à une collaboration établie avec l'équipe du professeur C. Muller de l'Institut Pharmaceutique de l'Université de Bonn. Ces études pharmacologiques nous ont permis de déceler de nouveaux dérivés possédant une affinité de l'ordre de 30 à 100 nM et présentant, pour certains, une sélectivité notable vis-à-vis des récepteurs de l'adénosine A1 ou A2A. Ainsi, un groupement cycloalkyle, de type cyclopentyle ou noradamantyle, substitué en position 8 et associé à une chaîne propylique en position 1 (xanthines 3e et 3g) semble constituer un bon pharmacophore pour l'affinité vis-à-vis du récepteur de l'adénosine A1. De plus, ce modèle de xanthine ne présente pas de substitution en position 7. Par ailleurs, les motifs xanthines présentant un groupement méthoxystyryle en position 8 associé à une chaîne propargyle en position 1 (composé 3f) et un groupe méthyle en position 7 (composé 3k) ont révélé une affinité remarquable vis-à-vis du récepteur A2A.
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Seddon, Gavin M. "Radiation effects on biochemical systems." Thesis, University of Salford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313912.

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Mapengo, Raphaël. "Cinétiques de méthylation et de deutérométhylation des xanthines : évaluation des effets isotopiques : essai de corrélation aux réactions de N-déméthylation biologique." Lyon 1, 1990. http://www.theses.fr/1990LYO1T168.

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Calenzo, Chappe Valérie (19. "Régulation et pharmacologie du canal chlorure CFTR : implication des récepteurs purinergiques de type P2Y dans l'activation du canal CFTR par les dérivés xanthines." Aix-Marseille 1, 1999. http://www.theses.fr/1999AIX11026.

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Les epitheliums forment une barriere continue entre deux compartiments et permettent le transport d'ions, de solutes et de macromolecules. L'absorption de na + et la secretion de cl sont des elements majeurs de la fonction epitheliale. Le canal cftr (cystic fibrosis transmembrane conductance regulator), membre de la superfamille des transporteurs abc (atp binding cassette), est une des clefs de la regulation du transport de chlorure dans les epitheliums. La mucoviscidose est la maladie genetique la plus repandue dans les populations europeennes et nord-americaines. Elle se caracterise par une modification des transports ioniques epitheliaux due a un mauvais adressage ou un dysfonctionnement du canal cftr regule par l'ampc et l'atp. On ne possede pas de modeles structuraux ou moleculaires des canaux chlorure actives par le calcium, mais leur regulation par les recepteurs purinergiques de type p2 est bien connue. L'analyse des regulations par l'ampc et l'atp de ces canaux nous a permis de montrer l'importance des croisements entre ces voies de signalisation. Nous montrons que la permeabilite chlorure, activee par le calcium, des cellules frtl-5 (fischer rat thyroid) est controlee par une stimulation chronique de la voie ampc et que l'activite du canal cftr transfecte dans les cellules cho (chinese hamster ovary) est controlee par le recepteur purinergique p2u. L'etude pharmacologique du canal cftr montre que des formes actives, inactives et antagonistes de derives xanthines sont obtenues en modifiant des substitutions alkyl en position n1. La regulation du canal cftr par les seconds messagers suggere que l'activite des xanthines depend essentiellement de l'inhibition du recepteur p2u. Nos resultats montrent que les recepteurs purinergiques p2u jouent un role central dans la regulation du niveau intracellulaire de calcium et d'ampc, et donc de l'activite des canaux chlorure des cellules epitheliales.
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Essandoh, Ernest. "Structural studies of organic crystals of pharmaceutical relevance : correlation of crystal structure analysis with recognised non-bonded structural motifs in the organic solid state." Thesis, University of Bradford, 2009. http://hdl.handle.net/10454/4444.

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Pharmaceutical solids tend to exist in different physical forms termed as polymorphs. Issues about pharmaceutical systems are mainly concerned with the active ingredient's physico-chemical stability and bioavailability. The main aim of this study is to investigate the non-bonded interactions in pharmaceutical solids that govern the physical pharmaceutics performance of such materials and through the use of structural techniques and correlation of these results with crystal structural database to establish the presence of physical motifs in selected systems. Structural motifs were identified by the use of single crystal and crystal packing analysis on diverse range of pharma-relevant materials including chalcones, cryptolepines, biguanides and xanthines. These selected systems were validated using functional group and molecular analysis and correlating them to the Cambridge Structural Database. Crystallization studies are done on these selected systems as well as exploiting those using synthetic analogues. A total of 51 crystal structures were investigated including 16 new structure determinations. Addition synthesis of new xanthines to investigate novel intermolecular patterns was also undertaken. The understanding and exploitation of intermolecular interactions involving hydrogen bonds and coordination complexation during packing can be used in the design and synthesis of solid state molecular structures with desired physical and chemical properties.
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Books on the topic "Xanthines"

1

Xanthines and cancer: An experimental study of tumour inhibition. Aberdeen: Aberdeen University Press, 1988.

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1946-, Barnes Peter J., ed. The Mechanism of action of Xanthines in respiratory disease. London: Royal Society of Medicine Services, 1988.

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Karl-Erik, Andersson, Persson C. G. A, and AB Draco, eds. Anti-asthma xanthines and adenosine: Proceedings of a symposium in Copenhagen, February 22-23, 1985. Amsterdam: Excerpta Medica, 1985.

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Services, IBC Technical, ed. Xanthines: an update on their chemistry, pharmacology and therapeutics: Conference documentation : London, 1988. London: IBC TechnicalServices, 1988.

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1944-, Costello J. F., Piper Priscilla J, and Royal Society of Medicine (Great Britain). Respiratory Section., eds. Methylxanthines and phosphodiesterase inhibitors in the treatment of airways disease: The proceedings of a meeting held by the Respiratory Section of the Royal Society of Medicine, London, November 1993. London: Parthenon Pub. Group, 1994.

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International Workshop on Adenosine and Xanthine Derivatives (1984 Wiesbaden, Germany). Adenosine: Receptors and modulation of cell function : proceedings of the International Workshop on Adenosine and Xanthine derivatives. Oxford [Oxfordshire]: IRL Press, 1985.

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Nilson, G. The mountain vipers of the Middle East: The Vipera xanthina complex (Reptilia, Viperidae). Bonn: Zoologisches Forschungsinstitut und Museum Alexander Koenig, 1986.

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Neish, William J. P. Xanthines and cancer. Aberdeen University Press, 1988.

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(Editor), K. E. Andersson, and C.G.A. Persson (Editor), eds. Anti-asthma Xanthines and Adenosine (Current clinical practice series). Elsevier, 1986.

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Neish, William J. P. Xanthines and Cancer: An Experimental Study of Tumour Inhibition. MacMillan Publishing Company, 1988.

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Book chapters on the topic "Xanthines"

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Schuckit, Marc A. "Xanthines (Caffeine) and Nicotine." In Drug and Alcohol Abuse, 208–28. Boston, MA: Springer US, 1989. http://dx.doi.org/10.1007/978-1-4757-0767-0_12.

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Schuckit, Marc A. "Xanthines (Caffeine) and Nicotine." In Drug and Alcohol Abuse, 251–73. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4757-2407-3_12.

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Schuckit, Marc A. "Xanthines (Caffeine) and Nicotine." In Drug and Alcohol Abuse, 254–77. Boston, MA: Springer US, 2000. http://dx.doi.org/10.1007/978-1-4757-3232-0_12.

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Tattersfield, Anne E., and Martin W. McNicol. "Theophylline and Related Xanthines." In Treatment in Clinical Medicine, 203–19. London: Springer London, 1987. http://dx.doi.org/10.1007/978-1-4471-3132-8_17.

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Spina, D., and C. P. Page. "Xanthines and Phosphodiesterase Inhibitors." In Handbook of Experimental Pharmacology, 63–91. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/164_2016_71.

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Müller, Christa E., and Kenneth A. Jacobson. "Xanthines as Adenosine Receptor Antagonists." In Methylxanthines, 151–99. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-13443-2_6.

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Persson, C. G. A., and R. Pauwels. "Pharmacology of Anti-Asthma Xanthines." In Pharmacology of Asthma, 207–25. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-75855-3_7.

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Favrod-Coune, Thierry, and Barbara Broers. "Addiction to Caffeine and Other Xanthines." In Textbook of Addiction Treatment, 215–28. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-36391-8_16.

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Favrod-Coune, Thierry, and Barbara Broers. "Addiction to Caffeine and Other Xanthines." In Textbook of Addiction Treatment: International Perspectives, 437–53. Milano: Springer Milan, 2014. http://dx.doi.org/10.1007/978-88-470-5322-9_18.

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Persson, Carl G. A., Ingrid Erjefalt, and Birgitta Gustafsson. "Xanthines — Symptomatic or Prophylactic in Asthma?" In Directions for New Anti-Asthma Drugs, 137–55. Basel: Birkhäuser Basel, 1988. http://dx.doi.org/10.1007/978-3-0348-9156-1_10.

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Conference papers on the topic "Xanthines"

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Mędza, Grzegorz, Jacek Wierzchowski, and David Shugar. "Fluorescent analogues of caffeine, theophylline, and other methyl-xanthines." In XIVth Symposium on Chemistry of Nucleic Acid Components. Prague: Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2008. http://dx.doi.org/10.1135/css200810478.

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Cazzola, Mario, Luigino Calzetta, Peter J. Barnes, Gerard J. Criner, Fernando J. Martinez, Alberto Papi, and Maria Gabriella Matera. "Efficacy and safety profile of xanthines in COPD: a network meta-analysis." In ERS International Congress 2018 abstracts. European Respiratory Society, 2018. http://dx.doi.org/10.1183/13993003.congress-2018.pa615.

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Ding, Rui, Barton A. Kamen, Jia Shi, and Kathleen W. Scotto. "Abstract 992: Regulation of ABCG2 lysosomal degradation by xanthines: Role of the PI3K/AKT pathway." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-992.

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Shatos, M., J. Doherty, D. Allen, and J. Hoak. "ALTERATIONS IN VASCULAR ENDOTHELIAL CELL FUNCTION BY OXYGEN-FREE RADICALS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643365.

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Abstract:
The vascular endothelium is a target for oxidant-induced damage in many disease states including hyperoxia, inflammation, ischemia and reperfusion injury. However, little is known concerning oxidant injury to endothelial cells and its relationship to hemostasis. Our studies have focused on the ability of oxygen free radicals to injure and/or alter selected vascular endothelial cell functions pertinent to the regulation of hemostasis. Xanthine and xanthine oxidase, a well-characterized generating system for the production of the superoxide anion radical (O− 2) was used to sublethally injure human umbilical vein endothelial cells (HUVE) in vitro. We examined the effects of a 15 min exposure of HUVE cells to xanthine (50μM), and xanthine oxidase (2.5-100mU) (previously determined to be non-toxic using trypan blue dye exclusion) on platelet adherence, and prostacyclin release using established assays. The antioxidant enzymes superoxide dismutase (SOD) 200μg/ml and catalase 50μg/ml were added to endothelium incubation systems to evaluate any protective effects upon O− 2-induced alterations. All experiments were conducted in a serum-free HEPES-Tyrode's buffer, pH 7.4 incubation system. Our results show that exposure of HUVE cells to sublethal concentrations of oxygen free radical generating systems causes significant enhancement of platelet adherence (65%) to injured endothelium. A 12-fold increase in prostacyclin release resulted after a 15 min treatment with xanthine and xanthine oxidase. The addition of exogenous PGI2 (150nM) to platelet-endothelial systems did not completely prevent the enhanced platelet adherence suggesting that lack of prostacyclin was not completely responsible for the adherence of platelets to O− 2 injured cells. When SOD and catalase, scavengers of O− 2 and H2O− 2, were added to treated cells, platelet adherence decreased by 42-77% and prostacyclin release approached that of control cultures. These data implicate an active participation of activated metabolites of molecular oxygen in the alteration of vascular endothelial cell function.
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Vanegas, D. C., C. Gomes, and E. S. McLamore. "Xanthine oxidase biosensor for monitoring meat spoilage." In SPIE Sensing Technology + Applications, edited by Brian M. Cullum and Eric S. McLamore. SPIE, 2014. http://dx.doi.org/10.1117/12.2050489.

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Royhoudhury, Sohini, Apoorva Shah, Ishaan Shah, Yogeswaran Umasankar, and Shekhar Bhansali. "Nano-Composite Enzymatic Xanthine Biosensor for Wound Diagnostics." In 2018 IEEE Sensors. IEEE, 2018. http://dx.doi.org/10.1109/icsens.2018.8589952.

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Tran, H., NN Le, AT Trinh, and TN Huynh. "Xanthine oxidase inhibitory activities of some Vietnamese medicinal plants." In 67th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) in cooperation with the French Society of Pharmacognosy AFERP. © Georg Thieme Verlag KG, 2019. http://dx.doi.org/10.1055/s-0039-3400114.

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Matos, Maria João, Fernanda Borges, Lourdes Santana, Eugenio Uriarte, Rosaria Medda, Francesca Pintus, Martina Caboni, Benedetta Era, Antonella Fais, and Amalia Di Petrillo. "Interest of 3-arylcoumarins as xanthine oxidase inhibitors." In The 19th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2015. http://dx.doi.org/10.3390/ecsoc-19-b002.

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Sari, Besse Illang, Hasnah Natsir, Seniwati Dali, Abdul Wahid Wahab, Nunuk Hariani Soekamto, Maming, and Andi Akbar. "Isolation, fractionation, and characterization of xanthine oxidase from goat’s milk." In THE 9TH INTERNATIONAL CONFERENCE OF THE INDONESIAN CHEMICAL SOCIETY ICICS 2021: Toward a Meaningful Society. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0104306.

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Ding, Rui, Jia Shi, and Kathleen W. Scotto. "Abstract 1746: Modulation of ABCG2 mediated multidrug resistance by xanthine derivatives." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-1746.

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Reports on the topic "Xanthines"

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Bedina, S. A., E. E. Mozgovaia, E. A. Tikhomirova, M. A. Mamus, S. S. Dotsenko, and A. S. Trofimenko. Xanthine oxidase and xanthine dehydrogenase activity in rheumatoid arthritis: the enzyme profile of blood plasma. ООО "ИМА-Пресс", 2018. http://dx.doi.org/10.18411/1995-4484-2018-56-33-8.

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Bedina, S. A., E. E. Mozgovaya, I. A. Zborovskaya, A. S. Trofimenko, and E. G. Korenskaya. ENZYMATIC PROFILE OF BLOOD PLASMA IN RHEUMATOID ARTHRITIS: ACTIVITY OF XANTHINE OXIDASE, XANTHINE DEHYDROGENASE AND SUPEROXIDE DISMUTASE. Планета, 2018. http://dx.doi.org/10.18411/978-5-907109-24-7-2018-xxxv-54-61.

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Bedina, S. A., E. E. Mozgovaya, A. S. Trofimenko, S. S. Spitsina, M. A. Mamus, and E. A. Tikhomirova. ENZYMATIC PROFILE OF BLOOD PLASMA IN SYSTEMIC SCLEROSIS: ACTIVITY OF XANTHINE OXIDASE, XANTHINE DEHYDROGENASE AND SUPEROXIDE DISMUTASE. "PLANET", 2019. http://dx.doi.org/10.18411/978-5-907192-54-6-2019-xxxvi-38-45.

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Bedina, S. A., E. E. Mozgovaya, A. S. Trofimenko, N. M. Devyataeva, M. A. Mamus, S. S. Spitsyna, and E. A. Tikhomirova. XANTHINE OXIDASE, XANTHINE DEHYDROGENASE AND SUPEROXIDE DISMUTASE ACTIVITIES OF BLOOD PLASMA DEPENDING ON CLINICAL FEATURES OF SYSTEMIC SCLEROSIS. Academy of Natural Knowledge, 2019. http://dx.doi.org/10.18411/1996-3955-2019-10-268-272.

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Hodson, R. Analyzing Xanthine Dehydrogenase Iron-Sulfur Clusters Using Electron Paramagnetic Resonance Spectroscopy. Office of Scientific and Technical Information (OSTI), February 2004. http://dx.doi.org/10.2172/826721.

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Mozgovaia, E. E., S. A. Bedina, A. S. Trofimenko, and I. A. Zborovskaia. Features of changes in the activity of xanthine oxidase and xanthine dehydrogenase in lymphocyte lysates and blood plasma in rheumatoid arthritis with the use of glucocorticoids. ООО ИМА-Пресс, 2018. http://dx.doi.org/10.18411/1995-4484-2018-56-3(2)-55-56.

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Bedina, S. A., E. E. Mozgovaia, A. S. Trofimenko, and I. A. Zborovskaia. The activity of enzymes of the xanthine oxidase / xanthine dehydrogenase complex in blood plasma and lymphocyte lysates in patients with seropositive and seronegative forms of rheumatoid arthritis. Академия Естествознания, 2018. http://dx.doi.org/10.18411/1996-3955-2018-6-61-64.

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Mozgovaya, E. E., S. A. Bedina, A. S. Trofimenko, M. A. Mamus, S. S. Spitsina, and I. A. Zborovskaya. XANTHINE OXIDOREDUCTASE ACTIVITY IN BLOOD DEPENDING ON THE FUNCTIONAL CLASS OF RHEUMATOID ARTHRITIS PATIENTS. DOI CODE, 2021. http://dx.doi.org/10.18411/wco-iof-esceo-2021-428-429.

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Mozgovaya, E. E., S. A. Bedina, I. A. Zborovskaya, A. S. Trofimenko, M. A. Mamus, E. A. Tikhomirova, and S. S. Spitsina. XANTHINE OXIDOREDUCTASE AND SUPEROXIDE DISMUTASE ACTIVITIES OF BLOOD PLASMA DEPENDING ON TYPE OF SYSTEMIC SCLEROSIS. "PLANET", 2019. http://dx.doi.org/10.18411/978-5-907192-54-6-2019-xxxvi-120-127.

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Scott, J. Robert. Characterization of the Iron-Sulfur Clusters in Xanthine Dehydrogenase Using Electron Paramagnetic Resonance Spectroscopy and Magnetic Coupling Interactions. Office of Scientific and Technical Information (OSTI), February 2004. http://dx.doi.org/10.2172/826759.

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