Dissertations / Theses on the topic 'X-ray crystallography'
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Zora, J. A. "X-ray diffraction studies." Thesis, University of Sussex, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374467.
Full textWall, Clare. "Mathematical methods in protein x-ray crystallography." Thesis, University of York, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403863.
Full textMifsud, Richard William. "An exploration of some aspects of molecular replacement in macromolecular crystallography." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/282871.
Full textMeng, Guoyu. "Structural study of levansucrase by x-ray crystallography." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403446.
Full textGeissbühler, Marc Phillip. "X-ray interfacial crystallography of water on calcite /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/9634.
Full textNagpal, Akanksha. "Crystal Structures of Nitroalkane Oxidase: Insights into the Structural Basis for Substrate Specificity and the Catalytic Mechanism." Diss., Available online, Georgia Institute of Technology, 2005, 2005. http://etd.gatech.edu/theses/available/etd-07172005-152826/.
Full textDr. Allen M. Orville, Committee Chair ; Dr. Loren D. Williams, Committee Member ; Dr. Donald F. Doyle, Committee Member ; Dr. Dale E. Edmondson, Committee Member ; Dr. Giovanni Gadda, Committee Member.
Oblezov, Alexandr Evgenievich. "Crystal structure determination at the Center for X-ray Crystallography a practical guide /." [Gainesville, Fla.] : University of Florida, 2003. http://purl.fcla.edu/fcla/etd/UFE0002700.
Full textCollins, Anna. "The X-ray crystallography of Z'>1 materials." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437369.
Full textLo, Victor Lai-Xin. "Iterative projection algorithms and applications in x-ray crystallography." Thesis, University of Canterbury. Electrical and Computer Engineering, 2011. http://hdl.handle.net/10092/5476.
Full textAlves-Areias, A. "Investigation of host-guest interactions by x-ray crystallography." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395365.
Full textMalle, Dominggus. "Structural studies of microbial pullulanases by X-ray crystallography." Kyoto University, 2007. http://hdl.handle.net/2433/136530.
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新制・課程博士
博士(農学)
甲第13111号
農博第1616号
新制||農||940(附属図書館)
学位論文||H19||N4237(農学部図書室)
UT51-2007-H384
京都大学大学院農学研究科農学専攻
(主査)教授 内海 成, 教授 三上 文三, 教授 松村 康生
学位規則第4条第1項該当
Kinna, David John. "Pattern recognition in chemical crystallography." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318724.
Full textDerewenda, Urszula. "X-ray analysis of dimeric and hexameric insulins." Thesis, University of York, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.276517.
Full textSadow, Jennifer Beth Hurley. "The X-ray crystal structure of wheat translation initiation factor eIF4E /." Thesis, Full text (PDF) from UMI/Dissertation Abstracts International, 2002. http://wwwlib.umi.com/cr/utexas/fullcit?p3085056.
Full textSinangil, Mehmet Selcuk. "Estimation of crystal size and inhomogeneous strain in polymers using single peak analysis." Thesis, Georgia Institute of Technology, 1996. http://hdl.handle.net/1853/19096.
Full textBrooks-Bartlett, Jonathan C. "Quantifying radiation damage in X-ray diffraction experiments in structural biology." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:2f311eea-82bc-4200-846c-068ae26599ea.
Full textBarnett, Stephanie Jayne. "X-ray powder diffraction studies of ettringite and related systems." Thesis, Staffordshire University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244708.
Full textPearce, Nicholas M. "Multi-dataset electron density analysis methods for X-ray crystallography." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:44fb5cf1-93a4-43c0-805c-c85dffd29101.
Full textMancuso, Adrian P. "Experimental phase retrieval using coherent x-ray diffraction /." Connect to thesis, 2005. http://eprints.unimelb.edu.au/archive/00001775.
Full textBertrand, Jay Aaron. "X-ray crystal structures of inhibited bovine pancreatic trypsin." Diss., Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/27321.
Full textWalker, Andrew W. "Synthesis and X-ray structure analysis of novel calixarene receptors." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318740.
Full textNakane, Takanori. "Data processing pipeline for serial femtosecond crystallography at SACLA." Kyoto University, 2017. http://hdl.handle.net/2433/217997.
Full textKo, Reamonn, and 高耀駿. "X-ray crystallographic studies of Plasmodium falciparum adenylate kinases." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208020.
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Physiology
Master
Master of Philosophy
Andersson, Charlotta. "Structural studies of Erwinia carotovora L-Asparaginase by X-ray crystallography." Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-6188.
Full textBacterial L-asparaginases (E.C.3.5.1.1) are enzymes that catalyze the hydrolysis of L-asparagine to aspartic acid. For the past 30 years these enzymes have been used as therapeutic agents in the treatment of acute childhood lymphoblastic leukemia. The presence of a low rate glutaminase activity however causes serious side-effects to patients in treatment, as glutamine depletion give rise to neurotoxicity, anaphylaxis, and other hypersensitivity reactions. The interest in the enzyme from Erwinia carotovora originates from the fact that it shows a decreased glutaminase activity, and therefore the enzyme is expected to exhibit fewer side effects when used in therapy.
The main focus of this thesis is the crystal structure determination of L-asparaginase from Erwinia carotovora in the presence of aspartic acid at 2.5 Å resolution. The structure was refined to an R/Rfree factor of 19.9/28.6 with good stereochemistry.
L-Asparaginases are homotetrameric enzymes with a known 222 symmetry and an identical fold. The Erwinia carotovora asparaginase consists of eight monomers of 330 amino acid residues each. In this case the enzyme is active as a dimer of tetramers. The two tetramers have an inner twofold non-crystallographic symmetry. Each monomer forms two identifiable domains a large N-domain and a small C-domain. The active sites are found at a topological switch-point between those domains.
Cheung, Eugene. "Solid state photochemistry and x-ray crystallography of carbonyl-containing compounds." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape3/PQDD_0017/NQ56659.pdf.
Full textLane, S. E. "Structure determination by X-ray crystallography of some Group IIIB compounds." Thesis, Lancaster University, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355338.
Full textTate, Graeme. "New methods in protein X-ray crystallography using maximum entropy techniques." Thesis, University of Glasgow, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396507.
Full textFothergill, Michael David. "Analysis of mutants of tyrosyl-tRNA synthetase by X-ray crystallography." Thesis, Imperial College London, 1989. http://hdl.handle.net/10044/1/47439.
Full textPetersson, Britt. "Structural studies of peptide nucleic acid (PNA) by X-ray crystallography /." Cph. : The Danish University of Pharmaceutical Sciences, Department of Medicinal Chemistry, 2004. http://www.dfh.dk/phd/defences/Brittpetersson.htm.
Full textSzell, Patrick. "The Halogen Bond: X-Ray Crystallography and Multinuclear Magnetic Resonance Investigation." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39233.
Full textMoloney, Janet M. "X-ray structural studies of lanthanide macrocycles and biological molecules." Thesis, Durham University, 1999. http://etheses.dur.ac.uk/4599/.
Full textPrince, Stephen Michael. "Synchrotron X-ray studies of ribonuclease A and other molecules." Thesis, Liverpool John Moores University, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261490.
Full textLerche, Michael. "Elucidating the activation mechanism of the transcription factor DntR using X-ray crystallography and small angle X- ray scattering." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENV013/document.
Full textLysR type transcriptional regulatory (LTTR) proteins are the largest family of transcription factors amongst prokaryotes. In spite of the size of the family, structural information on full-length constructs of these proteins is very limited as they are often insoluble and very difficult to crystallize. From the few existing crystal structures, coupled with other biophysical evidence, it is known that the proteins mainly associate as homotetramers comprising a dimer of dimers. The dimers associate through large C-terminal domains in a “head-to-tail” fashion and are connected “head-to-head” through their N-terminal domains and the resulting homotetramers are activated by the binding of inducer molecules. Each C-terminal domain contain an inducer binding cavity (IBC) and is denoted an inducer binding domain (IBD), while the N-terminal dimers each bind a region of DNA via a winged helix-turn-helix (wHTH) motif.Unlike other transcription factors, LTTR proteins do not regulate expression by associating or disassociating with DNA. They bind to DNA in both their active and inactive states and the current consensus is that they regulate gene expression through large conformational changes that relax the bending of bound DNA. However, to this date, no crystal structures of a full length homotetrameric LTTR in both an active and inactive conformation exists, and thus their mechanism of transcriptional regulation remains structurally uncharacterized.The work described in this thesis has used the LTTR DntR as a model protein to futher structurally characterizes the activation mechanism of LTTR proteins. The first crystal structure of apo-DntR is presented as is the crystal structure of H169TDntR, a mutant which shows activity in the absence of an inducer molecule. Thermofluor assays performed on this mutant, show that it has a melting temperature similar to that of inducer bound DntR. Comparison of these crystal structures with the crystal structure of salicylate-bound DntR reveals that the protein in its apo-state adopts a compact IBC, which precludes the binding of an inducer molecule. Despite the evidence of thermofluor assays, the crystal structure of H169TDntR is very similar to that of apo-DntR suggesting that crystal packing effects impose strong limitations on the use of crystallography to elucidate the active and inactive conformations of DntR. Small Angle X-ray Scattering (SAXS) was thus used to study the structure of DntR in solution.SAXS study reveals that in solution DntR in its inactive apo-state is found in a slightly different conformation compared to that seen in its crystal structure. While maintaining a compact tetrameric C-terminal core the DNA binding wHTH dimers pack much closer to this than seen in the crystal structure and adopt a conformation that would result in much higher bending of bound DNA than previously postulated.SAXS studies of the constitutively active H169TDntR mutant confirm, as thermofluor assays had suggested, that in solution the structure of this protein is markedly different from its crystal structure. Indeed the solution structure of H169TDntR appears very like that of open-form homotetramers seen in the crystal structure of TsaR. This same effect was observed in solution scattering studies of inducer bound-and thus activated, DntR.The work presented in this thesis thus appears to confirm, as previously hypothesized, that upon activation DntR, and presumably all homotetrameric LTTRs, undergo a conformational change from a compact, to a much more open form that allows the relaxation of the bound DNA promoter region, exposing it to solvent and allows RNA polymerase access and thus initiate transcription
Fuller, Amy L. "Applications of X-ray crystallography : studies into the structural perturbations of peri-substituted naphthalene derivatives /." St Andrews, 2009. http://hdl.handle.net/10023/826.
Full textStrassner, Amanda M. "YZGD pyridoxal phosphatase from P. thiaminolyticus : subcloning, expression, and purification for x-ray crystallography structure determination /." Online version of thesis, 2008. http://hdl.handle.net/1850/6894.
Full textZhang, Kam Yong Jian. "On phase refinement and extension of macromolecular structures using both real and reciprocal space approaches." Thesis, University of York, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329753.
Full textPhetmung, Hirihattaya. "Structural studies of phospholes and phosphines." Thesis, University of Bristol, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324324.
Full textLiang, Shutian. "Structural basis of porcine RNase 4 recognition." Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665403.
Full textErskine, Peter Thomas. "X-ray crystallographic studies of 5-aminolaevulinic acid dehydratase." Thesis, Birkbeck (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299090.
Full textWilson, Claire. "Structure-reactivity relationships through X-ray and neutron diffraction studies." Thesis, Durham University, 1995. http://etheses.dur.ac.uk/5314/.
Full textSutton, Karim J. "Determining structure and atomic properties of materials using resonant X-ray diffraction." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:3944a985-9339-4c8c-970b-4b460848f200.
Full textDu, Junyi. "X-ray crystallographic studies of sulfur/selenium heteroatom compounds." Thesis, University of St Andrews, 2016. http://hdl.handle.net/10023/8984.
Full textLamont, R. Brian. "Studies of ring-chain tautomerism and molecular conformation by X-ray crystallography." Thesis, Queen's University Belfast, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335988.
Full textWong, S. F. "Synthesis, X-ray crystallography and '9'5Mo NMR spectroscopy of some molybdenum complexes." Thesis, University of Hertfordshire, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377905.
Full textAli, Rashid Majid Yousif. "Fragment-screening by X-ray crystallography of human vaccinia related kinase 1." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-166811.
Full textVoss, James. "Chikungunya envelope glycoprotein structure at neutral PH determined by X-ray crystallography." Paris 7, 2011. http://www.theses.fr/2011PA077021.
Full textChikungunya is an emerging mosquito-bome alphavirus that has caused widespread outbreaks of debilitating human disease in the past five years. CHIKV invasion of susceptible cells is mediated by two viral glycoproteins, E1 and E2, which carry the main antigenic determinants and form an icosahedral shell at the virion surface. Glycoprotein E2, derived from furin cleavage of the p62 precursor to E3 and E2 is responsible for receptor binding and is the major viral antigen. The E1 protein is responsible for inducing the fusion of viral and cellular membranes in the target cell endosome which is required for release of the viral nucleocapsid into the cytoplasm to initiale infection of a cell. While the structure of E1 has been determined, the structure of E2"has remained elusive over the years. This thesis reports the atomic structures of the mature (E3/E2/E1) and immature (P62/E1) envelope glycoprotein complexes from Chikungunya virus determined by X-ray crystallography using a recombinant protein construct. This construct contained the covalently linked ectodomains of p62 and E1. Diffracting crystals of the purified complexes were obtained at neutral pH when the linker joining the ectodomains was cleaved. The glycoprotein structures were fit into reconstructions of the alphavirus virion obtained from cryo-electron microscopy (cryoEM). This analysis resulted in an inferred atomic model of the entire 25MDa surface of the highly conserved alphavirus virion and allowed for the synthesis of a wealth of genetic, biochemical, immunological and electron microscopy data accumulated over the years on alphaviruses in general
Flood, Kelly-Jayne. "Comparative X-ray Structure Analyses of Multidentate Transition Metal Complexes." Thesis, University of Canterbury. Chemistry, 2006. http://hdl.handle.net/10092/1390.
Full textZhang, Weizhe, and 张蔚哲. "Development of crystallographic phasing method and structural study ofDscam." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B46940996.
Full textButterworth, Susanna. "Single crystal X-ray diffraction studies on small, medium and large molecules." Thesis, Durham University, 1996. http://etheses.dur.ac.uk/5352/.
Full textVandenakker, Focco. "X-ray crystallographic studies of heat-labile enterotoxins from Escherichia coli /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/9252.
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