Academic literature on the topic 'WW 2'
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Journal articles on the topic "WW 2"
Schilmann, Astrid, Andrés Sánchez-Pájaro, Marbella T. Ovilla-Muñoz, Juan Téllez-Sosa, Sugey Bravo-Romero, Sara Yuvisela Bahena-Reyes, Margarita Lobato, et al. "SARS-CoV-2 Wastewater Surveillance in Ten Cities from Mexico." Water 15, no. 4 (February 17, 2023): 799. http://dx.doi.org/10.3390/w15040799.
Full textRobotto, Angelo, Carlotta Olivero, Elisa Pozzi, Claudia Strumia, Camilla Crasà, Cristina Fedele, Maddalena Derosa, et al. "Efficient wastewater sample filtration improves the detection of SARS-CoV-2 variants: An extensive analysis based on sequencing parameters." PLOS ONE 19, no. 5 (May 24, 2024): e0304158. http://dx.doi.org/10.1371/journal.pone.0304158.
Full textAshton, Elizabeth, Benjamin Smeeton, and Stuart Weatherby. "ONE YEAR RETROSPECTIVE AUDIT OF CNS MALIGNANCY 2 WW REFERRALS." Journal of Neurology, Neurosurgery & Psychiatry 86, no. 11 (October 14, 2015): e4.126-e4. http://dx.doi.org/10.1136/jnnp-2015-312379.37.
Full textLOTT, J. Shaun, Sarah J. CODDINGTON-LAWSON, Paul H. TEESDALE-SPITTLE, and Fiona J. MCDONALD. "A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel." Biochemical Journal 361, no. 3 (January 25, 2002): 481–88. http://dx.doi.org/10.1042/bj3610481.
Full textSchillinger, William F., and David W. Archer. "Winter Triticale: A Long-Term Cropping Systems Experiment in a Dry Mediterranean Climate." Agronomy 10, no. 11 (November 13, 2020): 1777. http://dx.doi.org/10.3390/agronomy10111777.
Full textKakehi, Y., T. Kamoto, O. Ogawa, K. Tobisu, Y. Saito, H. Fukuda, and T. Kakizoe. "Prospective evaluation of a “Watchful Waiting” program using initial pathology criteria and PSA-doubling time monitoring for patients with stage T1c prostate cancer." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 14651. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.14651.
Full textFleet, M. R., S. F. Lincoln, and A. M. Hounslow. "Electron spin resonance of wool from Merino sheep heterozygous or homozygous for white fleece." Animal Science 47, no. 1 (August 1988): 97–103. http://dx.doi.org/10.1017/s0003356100037090.
Full textJasiński OFM, Andrzej Sebastian. "Pokutna modlitwa psalmisty." Scriptura Sacra, no. 21 (July 17, 2021): 71–83. http://dx.doi.org/10.25167/scrs/4158.
Full textGomes, Marta, Maria Bartolomeu, Cátia Vieira, Ana T. P. C. Gomes, Maria Amparo F. Faustino, Maria Graça P. M. S. Neves, and Adelaide Almeida. "Photoinactivation of Phage Phi6 as a SARS-CoV-2 Model in Wastewater: Evidence of Efficacy and Safety." Microorganisms 10, no. 3 (March 19, 2022): 659. http://dx.doi.org/10.3390/microorganisms10030659.
Full textKamynina, Elena, Caroline Tauxe, and Olivier Staub. "Distinct characteristics of two human Nedd4 proteins with respect to epithelial Na+ channel regulation." American Journal of Physiology-Renal Physiology 281, no. 3 (September 1, 2001): F469—F477. http://dx.doi.org/10.1152/ajprenal.2001.281.3.f469.
Full textDissertations / Theses on the topic "WW 2"
Tenner, Katja. "Funktionelle Charakterisierung der humanen Tryptophanhydroxylase 2." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15669.
Full textTryptophan hydroxylase (TPH) catalyzes the rate limiting step of the synthesis of the important neurotransmitter serotonin. Recently a new TPH isoenzyme, TPH2, was discovered. It turned out that this isoenzyme is responsible for the serotonin synthesis within the central nervous system, whereas the TPH1 is merely the starting point of serotonin synthesis in peripheral tissues. Since dysfunction in the metabolism of serotonin is related to a large number of psychiatric diseases, the neuronal TPH2 moved into the centre of interest. As a basis for the pharmacological manipulation of the central nervous serotonergic system, without influencing the periphery, the identification of differences between the two isoenzymes is essential. In this thesis it was shown that TPH1 and 2 not only differ in their expression sites but also in their basic biochemical characteristics. TPH1 turned out to be the more active enzyme. Furthermore it was shown that the N- and C-termini of TPH2 have an inhibitory respectively activating influence on the enzymatic activity. Therefore they became interesting targets for pharmacological interference, whereas the N-terminus as a TPH2 specific structure would facilitate the manipulation of the central nervous serotonergic system without exerting influence on the peripheral system. In further projects the existence of at least two protein kinase A phosphorylation sites could be verified, whereas the phosphorylation doesn’t seem to have any influence on the enzymatic activity, a high throughput assay for determination of TPH activity, based on a fluorometric principle, was developed, Tubulin beta2A was identified as a TPH2 interaction partner, the effect of a SNP in the Tph2 gene that decreases the TPH2 activity in vitro on the serotonin level and the behaviour of different mouse strains could be rated as insignificant by the generation of congenic mice und the expression of TPH1 mRNA was identified as a marker for endometrial cancer.
Labonne, B. "Origine et manifestation de la brisure de supersymétrie : Phénoménologie de l'annihilation de neutralinos en Zh et WW. Représentation (0,1/2) et dualité." Phd thesis, Université de la Méditerranée - Aix-Marseille II, 2007. http://tel.archives-ouvertes.fr/tel-00194510.
Full textD'un point de vue plus formel, les différentes représentations sur le super-espace du multiplet (0,1/2) sont passées en revue. Nous nous concentrons sur deux représentations spécifiques, le multiplet de 3-forme et le multiplet X. Le premier nous permet de réaliser un mécanisme de brisure de supersymétrie de type O'Raifeartaigh, sans singlet dans le superpotentiel. Le second multiplet contient les propriétés d'une brisure de supersymétrie. Nous mettons en évidence une relation de dualité entre ces deux représentations.
Labonne, Benjamin. "Origine et manifestation de la brisure de supersymétrie : Phénoménologie de l'annihilation de neutralinos en Zh et WW : Représentation (0,1/2) et dualité." Aix-Marseille 2, 2007. http://www.theses.fr/2007AIX22008.
Full textMosienko, Valentina. "Behavioral, neuronal, and development consequences of genetically decreased tryptophan hydroxylase 2 activity." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/16885.
Full textSerotonin (5-HT) is a major neurotransmitter in the brain biosynthesis of which is initiated by tryptophan hydroxylase 2 (TPH2). Polymorphisms in the TPH2 gene are suggested as risk factors associated with depression and anxiety in humans. Furthermore, the most frequently prescribed antidepressants and anxiolytics target the serotonergic system. However, the question whether a complete ablation or partial reduction in brain serotonin leads to the developmental, neurochemical, or psychological abnormalities remains unresolved. In this study, I took advantage of mouse lines with various degree of decrease in TPH2 activity in order to dissect the impact of 5-HT loss on development, brain neurochemistry and behavior. Using Tph2-deficient mice I showed that central serotonin is essential for normal postnatal, but not prenatal development. Growth retardation of Tph2-/- mice was not a result of a disruption of the hypothalamo-pituitary-adrenal axis, metabolic abnormalities, or impaired thermoregulation, but could result from reduced ultrasonic vocalization. I tested Tph2-/- mice along with other newly generated mouse models with partial TPH2 reduction, and showed that 20% reduction in central serotonin is not enough to cause changes in anxiety- and depression-like behaviors most likely due to compensatory mechanisms including reduced serotonin metabolism and increased 5-HT1A receptor sensitivity. However, complete loss of central serotonin leads to a depression-like phenotype, reduced anxiety-like behavior, and exaggerated aggression, but no differences in activity, olfaction, memory, and adult neurogenesis. Fluoxetine treatment of Tph2-/- mice revealed serotonin-independent action of this antidepressant on anxiety- and depression-like behavior. Furthermore, fluoxetine drastically reduced the brain 5-HT content in mice with low TPH2 activity indicating that TPH2 activity may determine the efficiency of antidepressants targeting the serotonergic system.
Kaup, Daniel. "Wirkung der AT2-Überexpression auf Collagen I alpha 2-mRNA-Gehalt und Migration porciner kardialer Fibroblasten." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2003. http://dx.doi.org/10.18452/14848.
Full textIn this work the influence of expression and stimulation of the human AT2 receptor on Collagen I alpha 2-mRNA-content and migration of porcine cardiac fibroblastst was tested to clarify the question if AT2 receptors promote AT1 antagonistic antifibrotic and antimigratory effects on collagen I alpha 2-mRNA content and migration. To examine the AT2 receptor function in the cell culture AT2 cDNA was transferred into fibroblasts by adenoviral transduction and the AT2 receptor was overexpressed. Through the use of RT-PCR the relative changes in collagen I alpha 2-mRNA content in TGF-beta1 stimulated and TGF-beta1 plus Ang II stimulated fibroblasts were assayed and compared to the unstimulated control. All values were referred to a reference gene (beta-actin). Stimulation of AT2 receptors did not change the relative collagen I alpha 2-mRNA content of the fibroblasts significantly compared to antisense-(Ad5TA2) transduced fibroblasts. In the modified Boyden-chamber the AT2 mediated effect of Ang II, hPDGF-BB and the combination of both on migration was assessed. The stimulation of AT2 receptors with Ang II inhibited migration compared to nontransduced fibroblasts. In combination with hPDGF-BB Ang II did not change the migration in AT2 overexpressing fibroblasts compared to antisense-(Ad5TA2)-transduced fibroblasts. In the case of exclusive stimulation of AT2-expressing fibroblasts with hPDGF-BB a significantly lower migration was found compared to antisense-(Ad5TA2)-transduced fibroblasts. The underlying therory that AT2 expression and stimulation inhibits the relative collagen I alpha 2-mRNA content could not be confirmed in this work. This did not reveal an inhibitory AT2 mediated effect of Ang II in respect to the TGF-beta1 induced collagen I alpha 2-mRNA content. In contrast to that Ang II stimulation of overexpressed AT2 receptors led to a decreased migration and mediated an AT1 antagonistic effect.
DiCesare, Silvana. "The guanine nucleotide exchanger Vav2 interacts with c-ErbB-2 and induces alveolar morphogenesis of mammary epithelial cells." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2002. http://dx.doi.org/10.18452/14693.
Full textThe ErbB receptor tyrosine kinases constitute a subfamily of four structurally related members, the EGF receptor (ErbB-1), ErbB-2, ErbB-3 and ErbB-4. ErbB receptor tyrosine kinases are critical for embryonic development of central and peripheral neural structures and heart. In addition, ErbB receptors play an important role in the postnatal development of the mammary gland. Previous studies showed that activated ErbB-2 receptor induces alveolar morphogenesis of EpH4 mammary epithelial cells that are cultured on a three-dimensional matrix (termed Matrigel). However, the downstream signaling proteins that mediate this biological activity of ErbB-2 were unknown. In this work, Vav2 was identified as a direct interaction partner of tyrosine-phosphorylated ErbB receptors using the yeast two-hybrid system. Vav2 is a member of a family of guanine nucleotide exchange factors that induce cytoskeletal rearrangements, transcriptional alterations, and have oncogenic potential when activated. To test the ability of Vav2 to mediate morphogenic signals of ErbB-2, EpH4 cells overexpressing Vav2 protein were cultured on Matrigel. Indeed, Vav2 induces alveolar morphogenesis of EpH4 cells when activated either by oncogenic mutation or tyrosine phosphorylation by ErbB-2. The morphogenic activity of Vav2 requires the Dbl homology domain, which mediates GDP/GTP exchange. Dominant-negative Vav2 specifically blocks the morphogenic signals of ErbB-2 in EpH4 cells without interfering with ErbB2-induced mitogenesis. Importantly, Vav2 is co-expressed and interacts with ErbB-2 in the mammary glands of pregnant mice. Taken together, these results point to Vav2 as a candidate to mediate ErbB-2 signals for alveolar morphogenesis in vivo, which is a relevant step in the development of the mammary gland during pregnancy.
Corvaisier, Matthieu. "Implication des co-activateurs transcriptionnels YAP/TAZ dans la régulation entre la croissance et la dormance tumorale des cellules du cancer colorectal : mécanismes moléculaires et perspectives thérapeutiques." Thesis, Lille 2, 2016. http://www.theses.fr/2016LIL2S028/document.
Full textColorectal cancer is the most frequent and lethal cancerous pathology from the digestive system. Each year in France, 41 000 new cases are diagnosed and 17 000 patients die due to this pathology. This high mortality is mainly due to the rate of patients with liver metastatic lesions and the early relapse of those metastases after treatment. The use of chemotherapy prior to surgery induces a decrease of early relapse, however 2 years after resection this advantage is lost. Thus, understanding the mechanisms underlying escape to treatment is required to try to delay or prevent tumor recurrence.The aim of this doctoral work was to analyze clonal chemoresistant subpopulations derived from the colorectal cancer cell line HT29 after chronic exposure to 5-Fluorouracil (5FU) and molecular mechanisms associated with chemoresistance. The most chemoresistant clonal subpopulation, 5F31, stops its proliferation after treatment with high dose of 5FU, this behavior being associated with the modulation of the c-Yes/YAP axis. After treatment, 5F31 cells enter quiescence, interaction between c-Yes and YAP is lost and total and nuclear YAP protein expression reduces significantly (Igoudjil, Touil, Corvaisier et al. 2014, Clinical Cancer Research). The next step was to study functions of YAP protein in this chemotherapy- induced quiescence.Pharmacological or transient inhibition of YAP and its homolog TAZ, induces quiescence and reduces cellular growth in several colorectal cancer cell lines. On the other hand, overexpression of a constitutively active form of YAP in 5F31 cells forces cells to remain proliferative under 5FU treatment, enhancing 5F31 cell chemosensitivity to 5FU.Regarding proteic effectors, quiescence (either induced by 5FU or YAP/TAZ inhibition) is associated with loss of expression of the transcription factor c-Myc and Cyclin E1. In 5F31 cells expressing the active mutant form of YAP, Cyclin E1 expression is sustained after 5FU treatment through the activation of the transcription factor CREB. Cyclin E1 inhibition is sufficient to induce quiescence, therefore introducing this protein as one of the final effectors of YAP/TAZ co-activators in the regulation of the proliferation/quiescence switch in colorectal cancer cells (Corvaisier et al. 2016, Oncotarget).To conclude, our work reveals the importance of YAP/TAZ proteins for the maintenance of colorectal cancer cells proliferation through Cyclin E1 expression. Our work on liver metastases from patients with colorectal cancer shows that high expression of YAP/TAZ is connected to a higher proliferative index in metastatic lesions. Moreover, high YAP/TAZ expression is associated with shorter patient progression-free survival and shorter overall survival. Studying the expression and level of YAP/TAZ activation could be an interesting prognosis marker to anticipate metastatic relapse and potent druggable target to delay tumoral recurrence
Harms, Christoph Friedemann. "Endogene Systeme der Neuroprotektion." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2003. http://dx.doi.org/10.18452/14874.
Full textThe neuroprotective effect of melatonin and 17 beta-estradiol has been evaluated in several in vitro models of neuronal apoptosis and necrosis. Melatonin was not neuroprotective in three models of apoptosis but showed a pro-apoptotic effect in primary cortical neurons. Melatonin revealed to damage naïve neurons, too. Partial protection was observed against necrotic neurodegeneration after oxygen-glucose deprivation (OGD). The use of melatonin as a therapeutic agent might be of interest in neurodegenerative diseases with excitotoxic damage like epilepsia or ischemia, but is questioned in case of apoptotic neurodegeneration. 17 beta-estradiol was neuroprotectiv in both necrotic and apoptotic neurodegeneration. Differences in the mechanism of neuroprotetion and in the efficacy in different regions of the brain were observed. A neuroprotective effect was visible only in hippocampal and septal cultures if 17 beta-estradiol was applied 20 h prior (long term pre-treatment) but not in cortical neurons. This effect correlates with an increased density of estrogen receptor-alpha and an increased expression of anti-apoptotic proteins like Bcl-2 and Bcl-xL in these regions. These effect could be blocked with receptor antagonists, protein synthesis inhibitors and an inhibitor of the phosphatidylinositol 3-kinase. A short term pre-treatment revealed a receptor independent neuroprotective potential against OGD and glutamate toxicity. The failure of 17 beta-estradiol to protect cortical neurons against apoptosis could be an experimental basis to understand, why a long lasting treatment with estrogens of women with mild to moderate Alzheimer´s disease failed to inhibit the progress of the illness (Mulnard et al., 2000)
Masin, Marianela. "Identification and characterization of the molecular complex formed by the P2X2 receptor subunit and the adapter protein Fe65 in rat brain." Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-B6DE-2.
Full textJürgens, Daniel. "Untersuchung der elektrischen Hyperfeinwechselwirkung in Mn+1AXn-Phasen mittels der gestörten γ-γ-Winkelkorrelation." Doctoral thesis, 2013. http://hdl.handle.net/11858/00-1735-0000-0022-5EB8-2.
Full textBooks on the topic "WW 2"
Kachmar, Paul Elliot. WW-II 1/2. New York: Vantage Press, 2002.
Find full textSheets, John L. 745 survivor WW-2: Combat infantry rifleman. Gallipolis, OH: J.L. Sheets, 2000.
Find full textDrabkin, Artem. Red Army infantrymen remember the Great Patriotic War: A collection of interviews with 16 Soviet WW-2 veterans. Bloomington, IN: AuthorHouse, 2009.
Find full textDrabkin, Artem. Red Army infantrymen remember the Great Patriotic War: A collection of interviews with 16 Soviet WW-2 veterans. Bloomington, IN: AuthorHouse, 2009.
Find full textPictorial HIST WW 2. Main Street Books, 1990.
Find full textCasterson, Scott. Short History WW 2. Lulu Press, Inc., 2016.
Find full textKachmer, Paul Elliott. WW II 1/2. Vantage Pr, 2002.
Find full textWw Iii:behind Lin Nuk (Ww III : Behind the Lines, Book 2). Berkley, 1990.
Find full textCd-Rom, 1. Starhawks 2 C/D&W/Ww. N-TK ENTERTAINMENT, 1996.
Find full textPublishing, RH Value. War Planes & Air Battles WW 2. Crescent, 1988.
Find full textBook chapters on the topic "WW 2"
"2 Water into Wine (= WW)." In Lady E. S. Drower's Scholarly Correspondence, 73–133. BRILL, 2012. http://dx.doi.org/10.1163/9789004222472_004.
Full text"PP P PP aa a aa rr r rr tt t tt tt t tt ww w ww oo o oo." In Routledge Philosophy GuideBook to Plato and the Republic, 41–204. Routledge, 2002. http://dx.doi.org/10.4324/9780203069813-2.
Full textConference papers on the topic "WW 2"
Angelos, Mathew G., Elise C. Kohn, and Andrea K. McCollum. "Abstract LB-190: Novel cell cycle regulation through the WW-domain of the co-chaperone BAG3." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-lb-190.
Full textHill, Steven C. "Modeling nonlinear optics in microdroplets." In OSA Annual Meeting. Washington, D.C.: Optica Publishing Group, 1993. http://dx.doi.org/10.1364/oam.1993.ww.2.
Full textMcCollum, Andrea K., Mathew G. Angelos, Andrea D. Fischione, Marco Mineo, and Elise C. Kohn. "Abstract 2032: A novel function of WW domain binding protein 2 (WBP2) in regulating cytoskeletal function and cellular division through binding to co-chaperone BAG3." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2032.
Full textCadirci, Sertac, and Hasan Gunes. "Boundary Layer Separation Control on an Inclined Plate Using Jet and Vortex Actuator." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-62551.
Full textKondo, Taisei, Mikihito Otani, Takako Sinzi, Megumi Aibara, Kiyoshi Kurakawa, Kazumi Sekiguchi, Atsushi Kobayashi, Aiko Takazawa, and Masakazu Furuichi. "Life History Support System “LHS” - Recording Memories and Sharing Stories for Family Social Network." In AHFE 2023 Hawaii Edition. AHFE International, 2023. http://dx.doi.org/10.54941/ahfe1004376.
Full textReports on the topic "WW 2"
Litaor, Iggy, James Ippolito, Iris Zohar, and Michael Massey. Phosphorus capture recycling and utilization for sustainable agriculture using Al/organic composite water treatment residuals. United States Department of Agriculture, January 2015. http://dx.doi.org/10.32747/2015.7600037.bard.
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