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Journal articles on the topic 'Wound healing monitoring'

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Author: Grafiati

Published: 10 March 2023

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1

Greenwood, J. E., B. A. Crawley, S. L. Clark, P. R. Chadwick, D. A. Ellison, B. A. Oppenheim, and C. N. McCollum. "Monitoring wound healing by odour." Journal of Wound Care 6, no. 5 (May 2, 1997): 219–21. http://dx.doi.org/10.12968/jowc.1997.6.5.219.

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2

Delode, J., E. Rosow, C. Roth, J. Adams, and F. Langevin. "A wound-healing monitoring system." ITBM-RBM 22, no. 1 (February 2001): 49–52. http://dx.doi.org/10.1016/s1297-9562(01)90046-4.

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3

Patel, Shubham, Faheem Ershad, Min Zhao, Roslyn Rivkah Isseroff, Bin Duan, Yubin Zhou, Yong Wang, and Cunjiang Yu. "Wearable electronics for skin wound monitoring and healing." Soft Science 2, no. 2 (2022): 9. http://dx.doi.org/10.20517/ss.2022.13.

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Wound healing is one of the most complex processes in the human body, supported by many cellular events that are tightly coordinated to repair the wound efficiently. Chronic wounds have potentially life-threatening consequences. Traditional wound dressings come in direct contact with wounds to help them heal and avoid further complications. However, traditional wound dressings have some limitations. These dressings do not provide real-time information on wound conditions, leading clinicians to miss the best time for adjusting treatment. Moreover, the current diagnosis of wounds is relatively subjective. Wearable electronics have become a unique platform to potentially monitor wound conditions in a continuous manner accurately and even to serve as accelerated healing vehicles. In this review, we briefly discuss the wound status with some objective parameters/biomarkers influencing wound healing, followed by the presentation of various novel wearable devices used for monitoring wounds and accelerating wound healing. We further summarize the associated device working principles. This review concludes by highlighting some major challenges in wearable devices toward wound healing that need to be addressed by the research community.

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4

Pasche, Stéphanie, Silvia Angeloni, Réal Ischer, Martha Liley, Jean Luprano, and Guy Voirin. "Wearable Biosensors for Monitoring Wound Healing." Advances in Science and Technology 57 (September 2008): 80–87. http://dx.doi.org/10.4028/www.scientific.net/ast.57.80.

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Continuous health monitoring often requires hospitalization, which can become an expensive and inconvenient choice for the patient. In this perspective, wearable sensors that allow in situ biosensing constitute a very promising technology. This work aims to develop immunosensors for continuous monitoring of the wound healing process, based on pH changes, as well as on the concentrations of inflammatory proteins such as the C-reactive protein (CRP). Sensing principles include the use of responsive hydrogels that swell in response to changes in the surroundings, and the use of functional surfaces that specifically recognize the target protein. The detection principle is based on an optical signal, using the evanescent field of light propagating along a waveguide, probing refractive index changes. An optical sensing system that can be integrated in a wound dressing patch has been designed, including a white light source (LED), and a spectrometer for detection. The sensor was successfully tested in the laboratory with biological samples (blood serum), demonstrating reversible pH measurements between pH 6-8, and detection of changes in the concentration of CRP between 1 and 100 μg/ml. The sensor will later be integrated into wound dressings or bandages, forming a sensing patch that is connected via optical fibres and electrical wires to the detection system and power supply. This novel technology will be particularly valuable in applications such as the supervision of skin grafts and ulcer treatments.

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5

Sattar, Hina, Imran Sarwar Bajwa, Riaz ul Amin, Jan Muhammad, Muhammad Faheem Mushtaq, Rafaqut Kazmi, Muhammad Akram, Muhammad Ashraf, and Umar Shafi. "Smart Wound Hydration Monitoring Using Biosensors and Fuzzy Inference System." Wireless Communications and Mobile Computing 2019 (December 12, 2019): 1–15. http://dx.doi.org/10.1155/2019/8059629.

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Skin wounds either minor or chronic may heal up with different time durations. But, this time duration of healing could not be easily predicted as healing is affected by different factors, e.g., age, nutrition, medication, and surroundings. Despite these factors, wound characteristic also plays a role in the healing process. Wound characteristics include wound size, wound type, internal and external wound environment, body temperature, body oxygenation, wound hydration, and infection. Therefore, monitoring of wound healing also required careful consideration of wound characteristics. Although the healthcare domain contains many applications for detection and monitoring of diseases, the wound care domain requires efficient techniques and sensing systems for the identification of wound biomarkers such as temperature, blood pressure, oxygen, and infection status of wound using biosensors. In the current research, we provide a wound care solution based on a biosensor-based sensing system to measure basic biomarkers, considered as major wound characteristics, i.e., body temperature and body oxygenation, and design a fuzzy inference system to predict their effect on wound hydration, which ultimately recommends necessary actions to boost healing.

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6

HOFFMANN, K., K. WINKLER, S. EL-GAMMAL, and P. ALTMEYER. "A wound healing model with sonographic monitoring." Clinical and Experimental Dermatology 18, no. 3 (May 1993): 217–25. http://dx.doi.org/10.1111/j.1365-2230.1993.tb02174.x.

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7

Comino-Sanz, Inés María, Rafael Cabello Jaime, Josefina Arboledas Bellón, Juan Francisco Jiménez-García, Mercedes Muñoz-Conde, María José Díez Requena, Francisco Javier García Díaz, Begoña Castro, and Pedro Luis Pancorbo-Hidalgo. "A Digital Tool for Measuring Healing of Chronic Wounds Treated with an Antioxidant Dressing: A Case Series." International Journal of Environmental Research and Public Health 20, no. 5 (February 25, 2023): 4147. http://dx.doi.org/10.3390/ijerph20054147.

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(1) Abstract: Wound monitoring is an essential aspect in the evaluation of wound healing. This can be carried out with the multidimensional tool HELCOS, which develops a quantitative analysis and graphic representation of wound healing evolution via imaging. It compares the area and tissues present in the wound bed. This instrument is used for chronic wounds in which the healing process is altered. This article describes the potential use of this tool to improve the monitoring and follow-up of wounds and presents a case series of various chronic wounds with diverse etiology treated with an antioxidant dressing. (2) Methods: A secondary analysis of data from a case series of wounds treated with an antioxidant dressing and monitored with the HELCOS tool. (3) Results: The HELCOS tool is useful for measuring changes in the wound area and identifying wound bed tissues. In the six cases described in this article, the tool was able to monitor the healing of the wounds treated with the antioxidant dressing. (4) Conclusions: the monitoring of wound healing with this multidimensional HELCOS tool offers new possibilities to facilitate treatment decisions by healthcare professionals.

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8

Sattar, Hina, Imran Sarwar Bajwa, Riaz Ul-Amin, Aqsa Mahmood, Waheed Anwar, Bakhtiar Kasi, Rafaqut Kazmi, and Umar Farooq. "An Intelligent and Smart Environment Monitoring System for Healthcare." Applied Sciences 9, no. 19 (October 5, 2019): 4172. http://dx.doi.org/10.3390/app9194172.

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Skin wound healing is influenced by two kinds of environment i.e., exterior environment that is nearby to wound surface and interior environment that is the environment of the adjacent part under wound surface. Both types of environment play a vital role in wound healing, which may contribute to continuous or impaired wound healing. Although, different previous studies provided wound care solutions, but they focused on single environmental factors either wound moisture level, pH value or healing enzymes. Practically, it is insignificant to consider environmental effect by determination of single factors or two, as both types of environment contain a lot of other factors which must be part of investigation e.g., smoke, air pollution, air humidity, temperature, hydrogen gases etc. Also, previous studies didn’t classify overall healing either as continuous or impaired based on exterior environment effect. In current research work, we proposed an effective wound care solution based on exterior environment monitoring system integrated with Neural Network Model to consider exterior environment effect on wound healing process, either as continuous or impaired. Current research facilitates patients by providing them intelligent wound care solution to monitor and control wound healing at their home.

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9

Mallick, Sourav, Moinul Hasan, Nasrin Juyena, Dhriti Biswas, Mohammad Shoriotullah, and Md Alam. "Ultrasonographic monitoring of abdominal wound healing in ewes." Journal of Advanced Veterinary and Animal Research 4, no. 3 (2017): 261. http://dx.doi.org/10.5455/javar.2017.d221.

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10

Pakolpakçıl, Ayben, Bilgen Osman, Elif Tümay Özer, Yasemin Şahan, Behçet Becerir, Gökhan Göktalay, and Esra Karaca. "Halochromic composite nanofibrous mat for wound healing monitoring." Materials Research Express 6, no. 12 (January 6, 2020): 1250c3. http://dx.doi.org/10.1088/2053-1591/ab5dc1.

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11

Bassey, Christopher E., and Samuel Cowell. "Monitoring Diabetic Wound Healing with a Dielectric Probe." Biophysical Journal 106, no. 2 (January 2014): 618a—619a. http://dx.doi.org/10.1016/j.bpj.2013.11.3422.

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12

Pan, Chia-Pin, Yihui Shi, Khalid Amin, Charles S. Greenberg, Zishan Haroon, and Gregory W. Faris. "Wound healing monitoring using near infrared fluorescent fibrinogen." Biomedical Optics Express 1, no. 1 (July 27, 2010): 285. http://dx.doi.org/10.1364/boe.1.000285.

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13

Bodo, Michael, Timothy Settle, Joseph Royal, Eric Lombardini, Evelyn Sawyer, and Stephen W. Rothwell. "Multimodal noninvasive monitoring of soft tissue wound healing." Journal of Clinical Monitoring and Computing 27, no. 6 (July 6, 2013): 677–88. http://dx.doi.org/10.1007/s10877-013-9492-z.

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14

Qin, Wan, Yuandong Li, Jingang Wang, Xiaoli Qi, and Ruikang K. Wang. "In Vivo Monitoring of Microcirculation in Burn Healing Process with Optical Microangiography." Advances in Wound Care 5, no. 8 (August 2016): 332–37. http://dx.doi.org/10.1089/wound.2015.0669.

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15

Khan, Munezza Ata, Umar Ansari, and Murtaza Najabat Ali. "Real-time wound management through integrated pH sensors: a review." Sensor Review 35, no. 2 (March 16, 2015): 183–89. http://dx.doi.org/10.1108/sr-08-2014-689.

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Purpose – Real-time monitoring of wound or injured tissues is critical for speedy recovery, and the onset of a cascade of biochemical reactions provides potential biomarkers that facilitate the process of wound monitoring, e.g. pH, temperature, moisture level, bacterial load, cytokines, interleukins, etc. Among all the biomarkers, pH has been known to have a profound impact on the wound healing process, and is used to determine the incidence of bacterial infection of the wound (persistently elevated alkaline pH), proteolytic activity at the site of injury, take rate in skin grafting, wound healing stage and preparation for wound debridement. Design/methodology/approach – This review highlights the significance of pH in determination of clinical parameters and for selection of an appropriate treatment regime, and it presents an in-depth analysis of the designs and fabrication methods that use integrated pH sensors, which have been reported to date for the real-time monitoring of wound healing. Findings – For an expedited wound healing process, the significance of pH mandated the need of an integrated sensor system that would facilitate real-time monitoring of healing wounds and obviate the requirement of redressing or complicated testing procedures, which are both labor-intensive and painful for the patient. The review also discussed different types of sensor systems which were developed using hydrogel as a pH-responsive system coupled with voltammetry, potentiometry, impedimetric and flex-circuit inductive transducer systems. All of the mentioned devices have considerable potential for clinical applications, and there is need of in vivo testing to validate their efficiency and sensitivity under practical scenarios. Originality/value – This manuscript is an original review of literature, and permission has been granted to use the figures from previously published papers.

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16

Tang, Ning, Youbin Zheng, Xue Jiang, Cheng Zhou, Han Jin, Ke Jin, Weiwei Wu, and Hossam Haick. "Wearable Sensors and Systems for Wound Healing-Related pH and Temperature Detection." Micromachines 12, no. 4 (April 14, 2021): 430. http://dx.doi.org/10.3390/mi12040430.

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Wound healing is a complex tissue regeneration process involving many changes in multiple physiological parameters. The pH and temperature of a wound site have long been recognized as important biomarkers for assessing wound healing status. For effective wound management, wound dressings integrated with wearable sensors and systems used for continuous monitoring of pH and temperature have received much attention in recent years. Herein, recent advances in the development of wearable pH and temperature sensors and systems based on different sensing mechanisms for wound status monitoring and treatment are comprehensively summarized. Challenges in the areas of sensing performance, infection identification threshold, large-area 3-dimensional detection, and long-term reliable monitoring in current wearable sensors/systems and emerging solutions are emphasized, providing critical insights into the development of wearable sensors and systems for wound healing monitoring and management.

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17

Mamone, Virginia, Miriam Di Fonzo, Nicola Esposito, Mauro Ferrari, and Vincenzo Ferrari. "Monitoring Wound Healing With Contactless Measurements and Augmented Reality." IEEE Journal of Translational Engineering in Health and Medicine 8 (2020): 1–12. http://dx.doi.org/10.1109/jtehm.2020.2983156.

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18

Zhu, X., Y. Tang, J. Chen, S. Xiong, S. Zhuo, and J. Chen. "Monitoring wound healing of elastic cartilage using multiphoton microscopy." Osteoarthritis and Cartilage 21, no. 11 (November 2013): 1799–806. http://dx.doi.org/10.1016/j.joca.2013.08.016.

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19

Kenworthy, Pippa, Michael Phillips, Tiffany L. Grisbrook, William Gibson, Fiona M. Wood, and Dale W. Edgar. "Monitoring wound healing in minor burns—A novel approach." Burns 44, no. 1 (February 2018): 70–76. http://dx.doi.org/10.1016/j.burns.2017.06.007.

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20

Sattar, Hina, Imran Sarwar Bajwa, and Umar Farooq Shafi. "An Intelligent Air Quality Sensing System for Open-Skin Wound Monitoring." Electronics 8, no. 7 (July 17, 2019): 801. http://dx.doi.org/10.3390/electronics8070801.

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There are many factors that may have a significant effect on the skin wound healing process. The environment is one of them. Although different previous research woks have highlighted the role of environmental elements such as humidity, temperature, dust, etc., in the process of skin wound healing, there is no predefined method available to identify the favourable or adverse environment conditions that seriously affect (positively or negatively) the skin wound healing process. In the current research work, an IoT-based approach is used to design an AQSS (Air Quality Sensing System) using sensors for the acquisition of real-time environment data, and the SVM (Support Vector Machine) classifier is applied to classify environments into one of the two categories, i.e., “favourable”, and “unfavourable”. The proposed system is also supported with an Android application to provide an easy-to-use interface. The proposed system provides an easy and simple means for patients to evaluate the environmental parameters and monitor their effects in the process of open skin wound healing.

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21

Basov, Alexandr A., Sergey R. Fedosov, Vadim V. Malyshko, Anna A. Elkina, Oxana M. Lyasota, and Stepan S. Dzhimak. "Evaluation of effectiveness of a new treatment method for healing infected wounds: an animal model." Journal of Wound Care 30, no. 4 (April 2, 2021): 312–22. http://dx.doi.org/10.12968/jowc.2021.30.4.312.

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Objective: To evaluate the effectiveness of a new treatment method in healing superficial infected wounds compared with surgical debridement with chlorhexidine solution. Method: In this animal model, two wounds were created on the back of 10 male adult rabbits. Wounds treated by Method 1 were debrided using 0.02% chlorhexidine aqueous solution and an antibiotic topical ointment. Wounds treated by Method 2 wounds were treated using a newly developed device which enabled visual monitoring of the wound as it was treated with various pharmacological solutions (including antiseptic, antiseptic oxidant and an osmotically active agent) specifically formulated for each wound healing stage. Wound area size (using digital planimetry) and time taken to clean the wound were recorded, and biopsies were taken, at the beginning of the study and at various timepoints throughout. Result: It was observed that both wound cleaning and wound healing were accelerated by treatment with method 2 compared with method 1 (by 43.8% and 36.7%, respectively). There were also a significantly smaller number of complications in these wounds [p=0.0044] due to the positive ratios of neutrophils and fibroblasts in the wound cavities (from the third to the fourteenth day after wound modelling). Conclusion: Wounds treated with the new device in method 2 had a shorter wound healing time than wounds treated with a traditional method. The automated influx–outflow of solutions removed any fragments of necrotic tissue from the wound surface. Wounds were able to be monitored without the need to remove dressings. The transparent, airtight film, which allowed for wound monitoring without the need to remove dressings, meant that suturing was not required. This resulted in no complications in the wounds treated by this new method.

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22

Martin, Nuria, Claire Taylor, Nadine Hachach-Haram, and Therese Hona. "Wound care in patients with perineal reconstruction." Gastrointestinal Nursing 17, Sup9 (November 1, 2019): S44—S52. http://dx.doi.org/10.12968/gasn.2019.17.sup9.s44.

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Nurses play an essential role in monitoring and managing wounds after any surgery. This article focuses on how to optimise perineal wound healing after an extra-levator abdominoperineal excision of the rectum (ELAPE) or a pelvic exenteration for locally advanced rectal cancer. After radical rectal surgery, a perineal defect may be created that requires perineal reconstruction to fill the remaining cavity. Reconstruction of these defects is essential to restore form and function and reduce patient morbidity. A range of reconstructive options are available for perineal reconstruction. This includes inferior or superior gluteal artery perforator (IGAP/SGAP) flaps, which are fasciocutaneous flaps that provide robust, well-vascularised tissue to fill the perineal defect in a V-Y configuration while significantly reducing donor-site morbidity. The inferior gluteal artery perforator (IGAP) is most suitable when stoma formation is being considered. Possible complications after flap reconstruction include wound infection, abscess, flap necrosis, full-thickness dehiscence, bone exposure, delayed healing and persistent perineal sinus. Prevention is key to wound management; this encompasses regular monitoring, careful positioning and use of pressure-relieving equipment until the flap tissue is well perfused and healing well. Negative-pressure wound therapy is a therapeutic technique that uses a vacuum dressing to promote wound healing and enhance the formation of healthy granulation tissue and it can be useful to promote the healing of surgical wounds. Good nursing care is vital in optimising wound healing.

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23

Gao, Yuji, Dat T. Nguyen, Trifanny Yeo, Su Bin Lim, Wei Xian Tan, Leigh Edward Madden, Lin Jin, et al. "A flexible multiplexed immunosensor for point-of-care in situ wound monitoring." Science Advances 7, no. 21 (May 2021): eabg9614. http://dx.doi.org/10.1126/sciadv.abg9614.

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Chronic wounds arise from interruption of normal healing due to many potential pathophysiological factors. Monitoring these multivariate factors can provide personalized diagnostic information for wound management, but current sensing technologies use complex laboratory tests or track a limited number of wound parameters. We report a flexible biosensing platform for multiplexed profiling of the wound microenvironment, inflammation, and infection state at the point of care. This platform integrates a sensor array for measuring inflammatory mediators [tumor necrosis factor–α, interleukin-6 (IL-6), IL-8, and transforming growth factor–β1], microbial burden (Staphylococcus aureus), and physicochemical parameters (temperature and pH) with a microfluidic wound exudate collector and flexible electronics for wireless, smartphone-based data readout. We demonstrate in situ multiplexed monitoring in a mouse wound model and also profile wound exudates from patients with venous leg ulcers. This technology may facilitate more timely and personalized wound management to improve chronic wound healing outcomes.

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24

Li, Pengcheng, Feiyun Cui, Heying Chen, Yao Yang, Gang Li, Hongju Mao, and Xiaoyan Lyu. "A Microfluidic Cell Co-Culture Chip for the Monitoring of Interactions between Macrophages and Fibroblasts." Biosensors 13, no. 1 (December 31, 2022): 70. http://dx.doi.org/10.3390/bios13010070.

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Macrophages and fibroblasts are two types of important cells in wound healing. The development of novel platforms for studying the interrelationship between these two cells is crucial for the exploration of wound-healing mechanisms and drug development. In this study, a microfluidic chip composed of two layers was designed for the co-culturing of these two cells. An air valve was employed to isolate fibroblasts to simulate the wound-healing microenvironment. The confluence rate of fibroblasts in the co-culture system with different macrophages was explored to reflect the role of different macrophages in wound healing. It was demonstrated that M2-type macrophages could promote the activation and migration of fibroblasts and it can be inferred that they could promote the wound-healing process. The proposed microfluidic co-culture system was designed for non-contact cell–cell interactions, which has potential significance for the study of cell–cell interactions in biological processes such as wound healing, tumor microenvironment, and embryonic development.

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25

Tavakol, Daniel Naveed, Samantha C. Schwager, Lindsay A. Jeffries, Anthony Bruce, Bruce A. Corliss, Christopher A. DeRosa, Cassandra L. Fraser, Shayn M. Peirce, and Patrick S. Cottler. "Oxygen-Sensing Biomaterial Construct for Clinical Monitoring of Wound Healing." Advances in Skin & Wound Care 33, no. 8 (June 11, 2020): 428–36. http://dx.doi.org/10.1097/01.asw.0000666912.86854.2b.

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26

Chen, H., A. Nedzvedz, O. Nedzvedz, Sh Ye, Ch Chen, and S. Ablameyko. "Wound Healing Monitoring by Video Sequence Using Integral Optical Flow." Journal of Applied Spectroscopy 86, no. 3 (July 15, 2019): 435–42. http://dx.doi.org/10.1007/s10812-019-00838-w.

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27

Wahabzada, Mirwaes, Manuela Besser, Milad Khosravani, Matheus Thomas Kuska, Kristian Kersting, Anne-Katrin Mahlein, and Ewa Stürmer. "Monitoring wound healing in a 3D wound model by hyperspectral imaging and efficient clustering." PLOS ONE 12, no. 12 (December 7, 2017): e0186425. http://dx.doi.org/10.1371/journal.pone.0186425.

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28

Malone, Matthew, Saskia Schwarzer, Annie Walsh, Wei Xuan, Abdulaziz Al Gannass, Hugh G. Dickson, and Frank L. Bowling. "Monitoring wound progression to healing in diabetic foot ulcers using three-dimensional wound imaging." Journal of Diabetes and its Complications 34, no. 2 (February 2020): 107471. http://dx.doi.org/10.1016/j.jdiacomp.2019.107471.

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29

Castro, Pedro A. A., Cassio A. Lima, Mychel R. P. T. Morais, Telma M. T. Zorn, and Denise M. Zezell. "Monitoring the Progress and Healing Status of Burn Wounds Using Infrared Spectroscopy." Applied Spectroscopy 74, no. 7 (May 18, 2020): 758–66. http://dx.doi.org/10.1177/0003702820919446.

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Burns are one of the leading causes of morbidity worldwide and the most costly traumatic injuries. A better understanding of the molecular mechanisms in wound healing is required to accelerate tissue recovery and reduce the health economic impact. However, the standard techniques used to evaluate the biological events associated to wound repair are laborious, time-consuming, and/or require multiple assays/staining. Therefore, this study aims to evaluate the feasibility of Fourier transform infrared (FT-IR) spectroscopy to monitor the progress and healing status of burn wounds. Burn injuries were induced on Wistar rats by water vapor exposure and biopsied for further histopathological and spectroscopic evaluation at four time-points (3, 7, 14, and 21 days). Spectral data were preprocessed and compared by principal component analysis. Pairwise comparison of post-burn groups to each other revealed that metabolic activity induced by thermal injury decreases as the healing progresses. Higher amounts of carbohydrates, proteins, lipids, and nucleic acids were evidenced on days 3 and 7 compared to healthy skin and reduced amounts of these molecular structural units on days 14 and 21 post-burn. FT-IR spectroscopy was used to determine the healing status of a wound based on the biochemical information retained by spectral signatures in each phase of healing. Our findings demonstrate that FT-IR spectroscopy can monitor the biological events triggered by burn trauma as well as to detect the wound status including full recovery based on the spectral changes associated to the biochemical events in each phase.

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Schneider, Verena, Daniel Kruse, Ives Bernardelli de Mattos, Saskia Zöphel, Kendra-Kathrin Tiltmann, Amelie Reigl, Sarah Khan, Martin Funk, Karl Bodenschatz, and Florian Groeber-Becker. "A 3D In Vitro Model for Burn Wounds: Monitoring of Regeneration on the Epidermal Level." Biomedicines 9, no. 9 (September 3, 2021): 1153. http://dx.doi.org/10.3390/biomedicines9091153.

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Burns affect millions every year and a model to mimic the pathophysiology of such injuries in detail is required to better understand regeneration. The current gold standard for studying burn wounds are animal models, which are under criticism due to ethical considerations and a limited predictiveness. Here, we present a three-dimensional burn model, based on an open-source model, to monitor wound healing on the epidermal level. Skin equivalents were burned, using a preheated metal cylinder. The healing process was monitored regarding histomorphology, metabolic changes, inflammatory response and reepithelialization for 14 days. During this time, the wound size decreased from 25% to 5% of the model area and the inflammatory response (IL-1β, IL-6 and IL-8) showed a comparable course to wounding and healing in vivo. Additionally, the topical application of 5% dexpanthenol enhanced tissue morphology and the number of proliferative keratinocytes in the newly formed epidermis, but did not influence the overall reepithelialization rate. In summary, the model showed a comparable healing process to in vivo, and thus, offers the opportunity to better understand the physiology of thermal burn wound healing on the keratinocyte level.

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Sruthi, Mrs R. "IN VITRO CELL CYTOTOXICITY AND WOUND HEALING ACTIVITY OF TOPICAL FILM FORMING HYDROGEL OF PAPAIN UREA IN VERO CELLS." YMER Digital 21, no. 02 (February 12, 2022): 332–44. http://dx.doi.org/10.37896/ymer21.02/34.

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Wounds, whether acute or chronic, are one of the most common health problems worldwide, and medicative drugs are frequently used in wound healing. More research into wound treatment is being conducted at a rapid pace. For some wound types, enzymatic debridement of nonviable tissue remains the most effective debridement option. In theory, topical enzymes have been used in this therapy to remove necrotic tissue in the wound bed by digesting and dissolving the devitalized tissue. Papain, a plant-derived enzyme with a long history of clinical success, is one of these enzymes. The formulation of papain urea film forming gel is being used for wound repair. Vero cells were assessed in vitro for cell cytotoxicity and wound healing activity. When compared with the control, the results demonstrate significant healing activity and wound closure area. As a result of the findings of the study, the current formulation appears to be effective in healing wounds in in-vitro experiments

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32

Omidi, Meisam, Amir Yadegari, and Lobat Tayebi. "Wound dressing application of pH-sensitive carbon dots/chitosan hydrogel." RSC Advances 7, no. 18 (2017): 10638–49. http://dx.doi.org/10.1039/c6ra25340g.

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33

Nixon, Rachel. "Negative pressure wound therapy in the management of wounds." Companion Animal 24, no. 7 (July 2, 2019): 372–79. http://dx.doi.org/10.12968/coan.2019.0014.

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Negative pressure wound therapy, the controlled application of sub-atmospheric pressure to the wound surface, is becoming an increasingly popular treatment modality for the management of wounds in both human and veterinary medicine. It is proposed to exert a number of actions on the wound environment to promote healing. It is well recognised in the management of acute and chronic wounds and with skin grafting. It shows promise in cases of exposed orthopaedic implants and postoperatively on high-risk closed surgical incisions. Close monitoring following application is essential to ensure continued function. Importantly, it is typically well tolerated with minimal associated complications. However, significant complications are reported, if rarely, hence careful decision-making should be implemented to ensure appropriate use.

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34

Francesko, Antonio, Petya Petkova, and Tzanko Tzanov. "Hydrogel Dressings for Advanced Wound Management." Current Medicinal Chemistry 25, no. 41 (January 31, 2019): 5782–97. http://dx.doi.org/10.2174/0929867324666170920161246.

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Background: Composed in a large extent of water and due to their nonadhesiveness, hydrogels found their way to the wound dressing market as materials that provide a moisture environment for healing while being comfortable to the patient. Hydrogels’ exploitation is constantly increasing after evidences of their even broader therapeutic potential due to resemblance to dermal tissue and ability to induce partial skin regeneration. The innovation in advanced wound care is further directed to the development of so-called active dressings, where hydrogels are combined with components that enhance the primary purpose of providing a beneficial environment for wound healing. Objective: The objective of this review is to concisely describe the relevance of hydrogel dressings as platforms for delivery of active molecules for improved management of difficult- to-treat wounds. The emphasis is on the most recent advances in development of stimuli- responsive hydrogels, which allow for control over wound healing efficiency in response to different external modalities. Novel strategies for monitoring of the wound status and healing progress based on incorporation of sensor molecules into the hydrogel platforms are also discussed.

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Kekonen, Atte, Mikael Bergelin, Max Johansson, Narender Kumar Joon, Johan Bobacka, and Jari Viik. "Bioimpedance Sensor Array for Long-Term Monitoring of Wound Healing from Beneath the Primary Dressings and Controlled Formation of H2O2 Using Low-Intensity Direct Current." Sensors 19, no. 11 (May 31, 2019): 2505. http://dx.doi.org/10.3390/s19112505.

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Chronic wounds impose a significant financial burden for the healthcare system. Currently, assessment and monitoring of hard-to-heal wounds are often based on visual means and measuring the size of the wound. The primary wound dressings must be removed before assessment can be done. We have developed a quasi-monopolar bioimpedance-measurement-based method and a measurement system to determine the status of wound healing. The objective of this study was to demonstrate that with an appropriate setup, long-term monitoring of wound healing from beneath the primary dressings is feasible. The developed multielectrode sensor array was applied on the wound area and left under the primary dressings for 142 h. The impedance of the wounds and the surrounding intact skin area was measured regularly during the study at 150 Hz, 300 Hz, 1 kHz, and 5 kHz frequencies. At the end of the follow-up period, the wound impedance had reached the impedance of the intact skin at the higher frequencies and increased significantly at the lowest frequencies. The measurement frequency affected the measurement sensitivity in wound monitoring. The skin impedance remained stable over the measurement period. The sensor array also enabled the administration of periodical low-intensity direct current (LIDC) stimulation in order to create an antimicrobial environment across the wound area via the controlled formation of hydrogen peroxide (H2O2).

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Domische, Marian Yu, Andrii V. Maliar, Volodymyr V. Maliar, Vitalii V. Maliar, and Vasyl A. Maliar. "MONITORING ASSESSMENT OF THE EARLY PROCESS ON THE BACKGROUND OF TES THERAPY." Wiadomości Lekarskie 75, no. 10 (2022): 2445–48. http://dx.doi.org/10.36740/wlek202210124.

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The aim: To investigate and evaluate the effect of TEC therapy on the wound process. Materials and methods: On the models of clean, purulent and purulent-necrotic wounds in a comparative aspect, the wound process in the dynamics of wound healing in dental patients was studied in 233 patients, of which 105 were treated with TES therapy and 128 were treated with traditional treatment. A monitoring evaluation of the wound process was carried out based on the screening of the cytological picture of the wound contents, the study of the types of cytograms of smears-imprints from the wound on the 3rd, 6th and 9th days after surgical interventions. Results: It was established that against the background of TEC therapy, compared to traditional therapy, a positive trend of reparative processes in the wound was noted starting from the 3rd day. Destructive forms of granulocytes were significantly reduced with a simultaneous increase in the quantitative and qualitative composition of macrophages and an increase in the number of fibroblasts. The transition of the inflammatory phase to the regeneration phase was observed in the smear-imprints. Conclusions: The positive effect of TEC therapy on regenerative processes, both on clean and purulent and purulent-necrotic wounds at all stages of healing, has been estab¬lished. The cytological picture of the wound contents, the type of cytogram of smears-imprints are sensitive markers of regenerative processes in the wound, regardless of its type. These criteria for evaluating the course of the wound process can be successfully used for prognostic purposes.

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Qin, Mei, Hao Guo, Zhang Dai, Xu Yan, and Xin Ning. "Advances in flexible and wearable pH sensors for wound healing monitoring." Journal of Semiconductors 40, no. 11 (November 2019): 111607. http://dx.doi.org/10.1088/1674-4926/40/11/111607.

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Andreoli, Arianna, Marie-Thérèse Ruf, Ghislain Emmanuel Sopoh, Peter Schmid, and Gerd Pluschke. "Immunohistochemical Monitoring of Wound Healing in Antibiotic Treated Buruli Ulcer Patients." PLoS Neglected Tropical Diseases 8, no. 4 (April 24, 2014): e2809. http://dx.doi.org/10.1371/journal.pntd.0002809.

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HISAMATSU, T., J. PONEROS, G. TEARNEY, B. BOUMA, N. NISHIOKA, and D. PODOLSKY. "In vivo monitoring of intestinal wound healing using optical coherence tomography." Gastroenterology 120, no. 5 (April 2001): A150. http://dx.doi.org/10.1016/s0016-5085(01)80740-x.

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Hisamatsu, Tadakazu, John M. Poneros, Guillermo J. Tearney, Brett E. Bouma, Noman S. Nishioka, and Daniel K. Podolsky. "In vivo monitoring of intestinal wound healing using optical coherence tomography." Gastroenterology 120, no. 5 (April 2001): A150. http://dx.doi.org/10.1016/s0016-5085(08)80740-8.

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Hofer, H. P., E. Kukovetz, G. Egger, G. A. Khoschsorur, R. Wildburger, W. Petek, and R. J. Schaur. "PMN-related parameters for the monitoring of wound healing in traumatology." European Journal of Orthopaedic Surgery & Traumatology 5, no. 1 (December 1995): 21–26. http://dx.doi.org/10.1007/bf02716209.

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Jørgensen, Line Bisgaard, Ulrich Halekoh, Gregor B. E. Jemec, Jens Ahm Sørensen, and Knud Bonnet Yderstræde. "Monitoring Wound Healing of Diabetic Foot Ulcers Using Two-Dimensional and Three-Dimensional Wound Measurement Techniques: A Prospective Cohort Study." Advances in Wound Care 9, no. 10 (October 1, 2020): 553–63. http://dx.doi.org/10.1089/wound.2019.1000.

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Rico-Jimenez, Jose, Jang Hyuk Lee, Aneesh Alex, Salma Musaad, Eric Chaney, Ronit Barkalifa, Eric Olson, et al. "Non-invasive monitoring of pharmacodynamics during the skin wound healing process using multimodal optical microscopy." BMJ Open Diabetes Research & Care 8, no. 1 (April 2020): e000974. http://dx.doi.org/10.1136/bmjdrc-2019-000974.

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ObjectiveImpaired diabetic wound healing is one of the serious complications associated with diabetes. In patients with diabetes, this impairment is characterized by several physiological abnormalities such as metabolic changes, reduced collagen production, and diminished angiogenesis. We designed and developed a multimodal optical imaging system that can longitudinally monitor formation of new blood vessels, metabolic changes, and collagen deposition in a non-invasive, label-free manner.Research design and methodsThe closure of a skin wound in (db/db) mice, which presents delayed wound healing pathologically similar to conditions in human type 2 diabetes mellitus, was non-invasively followed using the custom-built multimodal microscope. In this microscope, optical coherence tomography angiography was used for studying neovascularization, fluorescence lifetime imaging microscopy for nicotinamide adenine dinucleotide (phosphate) (NAD(P)H) assessment, fluorescence intensity changes of NAD(P)H and flavin adenine dinucleotide (FAD) cofactors for evaluating metabolic changes, and second harmonic generation microscopy for analyzing collagen deposition and organization. The animals were separated into four groups: control, placebo, low concentration (LC), and high concentration (HC) treatment. Images of the wound and surrounding areas were acquired at different time points during a 28-day period.ResultsVarious physiological changes measured using the optical imaging modalities at different phases of wound healing were compared. A statistically significant improvement in the functional relationship between angiogenesis, metabolism, and structural integrity was observed in the HC group.ConclusionsThis study demonstrated the capability of multimodal optical imaging to non-invasively monitor various physiological aspects of the wound healing process, and thus become a promising tool in the development of better diagnostic, treatment, and monitoring strategies for diabetic wound care.

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Jamieson, Amanda Mercedes, Meredith Crane, Yun Xu, William Henry, and Jorge Albina. "Triaging the innate immune system: Responding to lung infections suppresses the dermal wound healing response." Journal of Immunology 200, no. 1_Supplement (May 1, 2018): 108.24. http://dx.doi.org/10.4049/jimmunol.200.supp.108.24.

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Abstract The development of pneumonia is a risk for hospitalized patients. Retrospective analysis of patient data revealed a strong correlation with the development of pneumonia and poor wound healing. Responding to lung infections and the healing wound response involve many of the same innate immune cell types, in particular macrophages, monocytes, and neutrophils. This study addresses the impact of lung infections on the ability to heal a dermal wound at a distal site. Using two in vivo models of injury combined with either bacterial (Klebsiella or Streptococcus) or viral (IAV) lung infections, this study unequivocally demonstrates that lung infections suppress the ability to heal wounds. Cutaneous wound healing is delayed in mice that have an ongoing lung infection. There is a decrease in trafficking of innate immune cells, in particular neutrophils and monocytes, into wounds of mice that have an ongoing lung infection. There are also decreased chemokines and cytokines in wounds from infected mice. Systemic changes of the innate immune system occur after wounding and infection that impact immune cell trafficking into wounds, but allow the immune response in the lung to remain intact. There are also alterations in the wound environment when there are simultaneous wounds and lung infections. By redirecting the innate immune response to the wounds we are able to increase wound healing. This information will allow for the better monitoring and supportive care for patients with this type of complex disease sequelae.

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Vadivel, S. A., and A. Balasubramaniam. "A REVIEW OF HERBAL MEDICINE USED IN WOUND HEALING." YMER Digital 21, no. 05 (May 27, 2022): 1162–70. http://dx.doi.org/10.37896/ymer21.05/d2.

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The main purpose of this review is to identify herbal medicines with great potential for treating minor wounds. The herbal medicine in wound healing for both traditional and nontraditional forms of the medicine dating back at least 5000 years. The herbs are minimal unwanted side effect. Based on medicine to prove efficacy of herbal medicines & focus on better understanding for their mechanism of actions, the more Scientist were increase on modern Scientific method and evidence. Quantitative human health benefit for herbal medicine is still rare or dispersed for limiting their proper valuation. The traditional medicinal plants are prepared by wound healing purposes covering a broad area of different skin related diseases. The herbal medicine in wound management involve disinfection, debridement & provision of a suitable environment for aiding the natural course of healing. Here we are report on some plants, which are used as wound healing agent in traditional medicine around the world

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Chan, Hannah O., Rakesh Joshi, Alexander Morzycki, Andrew C. Pun, Joshua N. Wong, and Collins Hong. "96.5 Using Computer Vision-Based Algorithms Trained on Mobile-Device Camera Images for Monitoring Burn Wound Healing." Journal of Burn Care & Research 43, Supplement_1 (March 23, 2022): S64. http://dx.doi.org/10.1093/jbcr/irac012.099.

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Abstract Introduction The appropriate characterization of burn depth and healing is paramount. Unfortunately, the accuracy of approximating thermal injury depth among all physicians is poor. While tools to improve detection accuracy, including laser doppler imaging and laser speckle imaging exist, these technologies are expensive and limited to specialized burn referral centres. They also do not provide an easy means for quantitative, interval tracking of burn healing. Considering these limitations, the application of artificial intelligence has garnered significant interest. We herein present the use of three novel machine learning and computer vision-based algorithms to track burn wound healing. Methods Convolutional neural network (CNN) models, were trained on 1800 2D color burn images, to classify them into four burn severities. These CNNs were used to develop saliency algorithms that identify the highest “attention” pixels used to recognize burns. Image-based algorithms that count these attention pixels of the CNN, count pixels representing red granulation of burns, and measure burns, were also developed. As proof-of-concept, we tracked the healing of a localized burn on a 25-year-old female patient. The patient suffered a scald on the dorsum of the foot, resulting in a deep partial-thickness burn. Opting out of surgical intervention, the patient visited the hospital over a 6-week period for treatment with non-adhesive dressings and silver nitrate. High-resolution images of the burn, with and without a fiducial marker, were captured with a smartphone camera every 7-days. Images were taken under institutional lighting and used as algorithmic inputs. Results Data analyses indicate that the healing of the open-wound area was accurately measured in millimetres (+/- 1.7 mm error) using a fiducial marker (18.3 mm diameter). The open-wound area shrank consistently from week 1 to week 6 seen in (Figure 1. a-b). The normalized, 2D colour images, where the “red” pixel value was counted (Figure 1. a-b), confirms the reduction of the red granulation in the wound. The saliency algorithm also measured a percentage reduction in the machine learning model’s total attention pixels over the 6-week period (Figure 1. c-d). This suggests that the model was less discerning of the healing burn wound over time, suggesting burn healing, which was also clinically validated.

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Mellergaard, Maiken, Stéphane Fauverghe, Carlotta Scarpa, Vladimir Luca Pozner, Søren Skov, Lise Hebert, Michael Nielsen, Franco Bassetto, and Luc Téot. "Evaluation of Fluorescent Light Energy for the Treatment of Acute Second-degree Burns." Military Medicine 186, Supplement_1 (January 1, 2021): 416–23. http://dx.doi.org/10.1093/milmed/usaa299.

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ABSTRACT Introduction The use of photobiomodulation has been proposed to improve wound healing for the last two decades. Recent development in photobiomodulation has led to the development of a novel biophotonic platform that utilizes fluorescent light energy (FLE) within the visible spectrum of light for healing of skin inflammation and wounds. Materials and Methods In this article, FLE was used in preliminary analysis on 18 case studies of acute second-degree burns and in a pilot study using an ex vivo human skin model. Efficacy of FLE on wound healing and tissue remodeling was evaluated by monitoring improvements in the treated tissues, assessing pain for the patients, and by performing human genome microarray analysis of FLE-treated human skin samples. Results Healing was reported for all 18 patients treated with FLE for acute second-degree burns without reported adverse effects or development of infections. Furthermore, preliminary ex vivo skin model data suggest that FLE impacts different cellular pathways including essential immune-modulatory mechanisms. Conclusions The results presented in this article are encouraging and suggest that FLE balances different stages of wound healing, which opens the door to initiating randomized controlled clinical trials for establishing the efficacy of FLE treatment in different phases of wound healing of second-degree burns.

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RoyChoudhury, Sohini, Yogeswaran Umasankar, Jose Jaller, Ingrid Herskovitz, Joshua Mervis, Evan Darwin, Penelope A. Hirt, et al. "Continuous Monitoring of Wound Healing Using a Wearable Enzymatic Uric Acid Biosensor." Journal of The Electrochemical Society 165, no. 8 (2018): B3168—B3175. http://dx.doi.org/10.1149/2.0231808jes.

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Wipke-Tevis, Deidre D. "Subcutaneous Tissue Oximetry: Implications for Wound Healing and Monitoring Critically Ill Patients." Critical Care Nursing Clinics of North America 7, no. 2 (June 1995): 275–85. http://dx.doi.org/10.1016/s0899-5885(18)30401-5.

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Kiesewetter, Lisa, Laura Littau, Heike Walles, Aldo R. Boccaccini, and Florian Groeber-Becker. "Reepithelialization in focus: Non-invasive monitoring of epidermal wound healing in vitro." Biosensors and Bioelectronics 142 (October 2019): 111555. http://dx.doi.org/10.1016/j.bios.2019.111555.

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