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Academic literature on the topic 'Wnt System'

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Published: 11 March 2023

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Journal articles on the topic "Wnt System"

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Staal, Frank J. T., Tiago C. Luis, and Machteld M. Tiemessen. "WNT signalling in the immune system: WNT is spreading its wings." Nature Reviews Immunology 8, no. 8 (August 2008): 581–93. http://dx.doi.org/10.1038/nri2360.

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Staal, Frank J. T., Tiago C. Luis, and Machteld M. Tiemessen. "Erratum: WNT signalling in the immune system: WNT is spreading its wings." Nature Reviews Immunology 15, no. 5 (April 7, 2015): 329. http://dx.doi.org/10.1038/nri3847.

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Park, Min Hee, Eun-Ah Sung, Margot Sell, and Wook-Jin Chae. "Dickkopf1: An Immunomodulator in Tissue Injury, Inflammation, and Repair." ImmunoHorizons 5, no. 11 (November 1, 2021): 898–908. http://dx.doi.org/10.4049/immunohorizons.2100015.

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Abstract Upon injury, inflammation and repair processes are orchestrated to maintain tissue homeostasis. The Wnt ligands play essential roles in cell differentiation and proliferation for tissue repair and regeneration. It is increasingly clear that Wnt ligands play crucial immune-modulatory roles in inflammatory diseases. It is predicted that comprehensive research regarding the cross-talk between nonimmune and immune cells in tissue injury and repair will flourish. The Wnt system and immune system interaction will be critical to understanding tissue injury, inflammation, and repair. In this study, we will first introduce the Wnt system and review the role of the Wnt system in tissue regeneration and repair. We will review the previous literature regarding how the Wnt ligands regulate the immune system. Next, we will discuss the current and future perspectives of Wnt ligands to target cancer and other immunological diseases. Finally, we will discuss the quintessential Wnt antagonist Dickkopf1 as an immunomodulatory ligand.
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Whangbo, J., J. Harris, and C. Kenyon. "Multiple levels of regulation specify the polarity of an asymmetric cell division in C. elegans." Development 127, no. 21 (November 1, 2000): 4587–98. http://dx.doi.org/10.1242/dev.127.21.4587.

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Wnt signaling systems play important roles in the generation of cell and tissue polarity during development. We describe a Wnt signaling system that acts in a new way to orient the polarity of an epidermal cell division in C. elegans. In this system, the EGL-20/Wnt signal acts in a permissive fashion to polarize the asymmetric division of a cell called V5. EGL-20 regulates this polarization by counteracting lateral signals from neighboring cells that would otherwise reverse the polarity of the V5 cell division. Our findings indicate that this lateral signaling pathway also involves Wnt pathway components. Overexpression of EGL-20 disrupts both the asymmetry and polarity of lateral epidermal cell divisions all along the anteroposterior (A/P) body axis. Together our findings suggest that multiple, inter-related Wnt signaling systems may act together to polarize asymmetric cell divisions in this tissue.
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Bordonaro, Michael. "Modular Cre/lox System and Genetic Therapeutics for Colorectal Cancer." Journal of Biomedicine and Biotechnology 2009 (2009): 1–12. http://dx.doi.org/10.1155/2009/358230.

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The Cre/lox system is a powerful tool for targeting therapeutic effectors in a wide variety of human disorders. I review a Cre/lox Wnt-targeted system that has shown promise against Wnt-positive colorectal cancer cell lines. In addition to Wnt-specific targeting of cell death inducers, the modular nature of this gene therapy model system can be exploited by designing positive and negative feedback loops to either amplify or inhibit Wnt activity for experimental or therapeutic benefit. I discuss the structural components and performance parameters of the system, the implication of these findings with respect to cancer stem cells, as well as the general applicability of this system to any disorder characterized by differential gene expression. I also consider the issue of gene delivery as well as in vivo testing requirements necessary for the further characterization and development of this system.
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Hollyday, Margaret, Jill A. McMahon, and Andrew P. McMahon. "Wnt expression patterns in chick embryo nervous system." Mechanisms of Development 52, no. 1 (July 1995): 9–25. http://dx.doi.org/10.1016/0925-4773(95)00385-e.

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Hrckulak, Dusan, Lucie Janeckova, Lucie Lanikova, Vitezslav Kriz, Monika Horazna, Olga Babosova, Martina Vojtechova, Katerina Galuskova, Eva Sloncova, and Vladimir Korinek. "Wnt Effector TCF4 Is Dispensable for Wnt Signaling in Human Cancer Cells." Genes 9, no. 9 (September 1, 2018): 439. http://dx.doi.org/10.3390/genes9090439.

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T-cell factor 4 (TCF4), together with β-catenin coactivator, functions as the major transcriptional mediator of the canonical wingless/integrated (Wnt) signaling pathway in the intestinal epithelium. The pathway activity is essential for both intestinal homeostasis and tumorigenesis. To date, several mouse models and cellular systems have been used to analyze TCF4 function. However, some findings were conflicting, especially those that were related to the defects observed in the mouse gastrointestinal tract after Tcf4 gene deletion, or to a potential tumor suppressive role of the gene in intestinal cancer cells or tumors. Here, we present the results obtained using a newly generated conditional Tcf4 allele that allows inactivation of all potential Tcf4 isoforms in the mouse tissue or small intestinal and colon organoids. We also employed the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system to disrupt the TCF4 gene in human cells. We showed that in adult mice, epithelial expression of Tcf4 is indispensable for cell proliferation and tumor initiation. However, in human cells, the TCF4 role is redundant with the related T-cell factor 1 (TCF1) and lymphoid enhancer-binding factor 1 (LEF1) transcription factors.
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Dickinson, M. E., R. Krumlauf, and A. P. McMahon. "Evidence for a mitogenic effect of Wnt-1 in the developing mammalian central nervous system." Development 120, no. 6 (June 1, 1994): 1453–71. http://dx.doi.org/10.1242/dev.120.6.1453.

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The analysis of mutant alleles at the Wnt-1 locus has demonstrated that Wnt-1-mediated cell signalling plays a critical role in development of distinct regions of the embryonic central nervous system (CNS). To determine how these signals participate in the formation of the CNS, we have ectopically expressed this factor in the spinal cord under the control of the Hoxb-4 Region A enhancer. Ectopic Wnt-1 expression causes a dramatic increase in the number of cells undergoing mitosis in the ventricular region and a concomitant ventricular expansion. Although this leads to consistent changes in the relative proportions of dorsal and ventral regions, Wnt-1 does not appear to act as a primary patterning signal. Rather, our experiments indicate that Wnt-1 can act as a mitogen in the developing CNS.
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Li, Shengchun, Yilin Zhang, Lihao Guo, and Xiaofang Li. "Potential Application of Alternate Tillage (AT) in a Rice–Wheat Rotation System—Based on Soil Physical Properties, Wheat Growth and Yield." Soil Systems 6, no. 3 (September 1, 2022): 70. http://dx.doi.org/10.3390/soilsystems6030070.

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Alternate tillage (AT) has the potential to reduce inputs and improve soil quality and crop yield, but there has been no research on the effect of AT on soil and wheat in a rice–wheat rotation system. In this study, field experiments were conducted to examine the effects of four tillage management methods (conventional tilling (CT) in each crop (RCT–WCT), no tilling (NT) in rice and conventional tilling in wheat (RNT–WCT, AT1), conventional tilling in rice and no tilling in wheat (RCT–WNT, AT2), and no tilling in each crop (RNT–WNT)) on the physical properties of soil, wheat growth, and yield. At the 0–5 cm soil layer, CT in the wheat season increased bulk density (BD) and decreased total properties, but it decreased BD at the 5–40 cm soil layer, and the effect of RCT–WCT was significantly greater than that of RNT–WCT. CT in the wheat season increased the root activity, root dry weight, net photosynthetic rate, leaf area index, antioxidant enzyme activities, and yield, and there was no significant effect between RCT–WCT and RNT–WCT. RNT-WCT has the potential to reduce inputs and maintain wheat yields.
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Hu, S., L. Yang, C. Wu, and TC-Y. Liu. "Regulation of Wnt signaling by physical exercise in the cell biological processes of the locomotor system." Physiology International 106, no. 1 (March 2019): 1–20. http://dx.doi.org/10.1556/2060.106.2019.07.

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In the past decade, researches on Wnt signaling in cell biology have made remarkable progress regarding our understanding of embryonic development, bone formation, muscle injury and repair, neurogenesis, and tumorigenesis. The study also showed that physical activity can reverse age-dependent decline in skeletal muscle, preventing osteoporosis, regenerative neurogenesis, hippocampal function, cognitive ability, and neuromuscular junction formation, and the age-dependent recession is highly correlated with Wnt signaling pathways. However, how the biological processes in cell and physical activity during/following exercise affect the Wnt signaling path of the locomotor system is largely unknown. In this study, we first briefly introduce the important features of the cellular biological processes of exercise in the locomotor system. Then, we discuss Wnt signaling and review the very few studies that have examined Wnt signaling pathways in cellular biological processes of the locomotor system during physical exercise.
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Dissertations / Theses on the topic "Wnt System"

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de, Bettignies A. S. "Wnt/Fz interactions in the developing central nervous system." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1444543/.

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Wnt signalling is central to many early developmental processes including embryonic patterning, programmed cell death and cell migration. Recent studies have implicated Wnt signalling in the formation of neuronal connections in the nervous system. Wntl a regulates synapse formation in the cerebellum by inducing presynaptic differentiation characterized by axonal remodelling and presynaptic assembly. A very similar gene, Wnt7b regulates dendritic development in hippocampal neurons, but can also trigger axonal remodelling. These different responses are due to the activation of different signalling pathways. We aim to identify the receptors triggering these processes in neurons. Intracellular signalling by Wnts is initiated by the activation of their seven transmembrane receptors Frizzled (Fz). Three known Wnt signalling pathways may be activated: the canonical, the planar cell polarity and Calcium pathways. Ten Fz receptors and 19 Wnts have been identified in the mouse genome. To begin to address what Fz receptors are used by Wnts, we examined the pattern of expression of Wnt 7a and Wnt 7b together with several Fz receptors during postnatal brain development. We found that Wnt7a,fz7, and fz3 are expressed in the postnatal and adult cerebellum. Wnt7b and fz3 are highly expressed in the postnatal hippocampus. These overlapping patterns of expression led us to investigate the ability of Wnt7a and Wnt7b to bind to the cell surface of HEK293 cells expressing the ligand-binding domain of Fz receptors. Binding of Wnt7a an -7b to Fz-3, -5, -7 and -8 was tested. Wnt7b binds Fz3 and Fz5, whilst Wnt7a binds Fz7 and Fz3. Signalling activity was then assessed by measuring TCF/LEF mediated transcription (Top-Flash assay) and by the increased levels of 6-catenin. Wnt-7a is able to activate the canonical pathway in Fz7 and Fz3/LRP6 transfected HEK293 cells. These studies highlight the idea that activation of the canonical / p-catenin pathway by Wnt7a can be mediated by Fz7 and the LRP6/Fz3 complex.
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Martin, Jennifer. "Wnt regulated transcription factor networks mediate vertebrate cardiogenesis." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Online version available for University members only until Feb. 15, 2012, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25801.

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Stevens, Mariana L. "Genomic integration of Wnt/β-catenin and BMP/Smad1 signaling coordinates digestive system development." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490352976010044.

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Iyengar, Sharanya. "Insights into Melanocyte Regeneration and Melanoma Initiation Using the Zebrafish Model System: A Dissertation." eScholarship@UMMS, 2015. https://escholarship.umassmed.edu/gsbs_diss/796.

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During regeneration, cells must coordinate proliferation and differentiation to rebuild tissues that are lost. Understanding how source cells execute the regeneration process has been a longstanding goal in regenerative biology with implications in wound healing and cell replacement therapies. Melanocytes are pigment-producing cells in the skin of vertebrates that can be lost during hair graying, injury and disease-related depigmentation. Melanoma is an aggressive skin cancer that develops from melanocytes, and it is hypothesized that melanoma cells have properties that are similar to melanocyte stem cells. To gain insight into melanocyte regeneration we set out to identify the source of regeneration melanocytes in adult zebrafish and the path through which progenitor cells reconstitute the pigment pattern. Using targeted cell ablation and single cell lineage-tracing analyses we identified that a majority of regeneration melanocytes arise through direct differentiation of mitfa-expressing progenitor cells. Concurrently, other mitfa-expressing cells divide symmetrically to generate additional mitfa-positive progenitors, thus maintaining regeneration capability. Using reporter assays and drug studies, we found that Wnt signaling gets turned on in progenitor cells during regeneration and Wnt inhibition after melanocyte ablation blocks regeneration. Based on our finding that Wnt signaling is active in differentiated melanocytes but not in the progenitor cells, we explored the role of Wnt signaling in tumor initiation. We found that approximately half of the melanomas are Wnt silent, and overexpression of dkk1b, a negative regulator of canonical Wnt signaling, accelerates melanoma onset. This work defines an unappreciated contribution by direct differentiation in melanocyte regeneration and suggests a broader role for this process in the maintenance of epithelial sheets. This study also identifies a shared pathway between melanocyte progenitors and melanoma cells, which could be applicable to other cancers.
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Iyengar, Sharanya. "Insights into Melanocyte Regeneration and Melanoma Initiation Using the Zebrafish Model System: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/796.

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During regeneration, cells must coordinate proliferation and differentiation to rebuild tissues that are lost. Understanding how source cells execute the regeneration process has been a longstanding goal in regenerative biology with implications in wound healing and cell replacement therapies. Melanocytes are pigment-producing cells in the skin of vertebrates that can be lost during hair graying, injury and disease-related depigmentation. Melanoma is an aggressive skin cancer that develops from melanocytes, and it is hypothesized that melanoma cells have properties that are similar to melanocyte stem cells. To gain insight into melanocyte regeneration we set out to identify the source of regeneration melanocytes in adult zebrafish and the path through which progenitor cells reconstitute the pigment pattern. Using targeted cell ablation and single cell lineage-tracing analyses we identified that a majority of regeneration melanocytes arise through direct differentiation of mitfa-expressing progenitor cells. Concurrently, other mitfa-expressing cells divide symmetrically to generate additional mitfa-positive progenitors, thus maintaining regeneration capability. Using reporter assays and drug studies, we found that Wnt signaling gets turned on in progenitor cells during regeneration and Wnt inhibition after melanocyte ablation blocks regeneration. Based on our finding that Wnt signaling is active in differentiated melanocytes but not in the progenitor cells, we explored the role of Wnt signaling in tumor initiation. We found that approximately half of the melanomas are Wnt silent, and overexpression of dkk1b, a negative regulator of canonical Wnt signaling, accelerates melanoma onset. This work defines an unappreciated contribution by direct differentiation in melanocyte regeneration and suggests a broader role for this process in the maintenance of epithelial sheets. This study also identifies a shared pathway between melanocyte progenitors and melanoma cells, which could be applicable to other cancers.
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Patthey, Cédric. "Induction of the isthmic organizer and specification of the neural plate border /." Umeå : Univ, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1811.

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Bertalot, Thomas. "Microenviroment modulation on plasticity of Enteric Nervous System derived cells." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423755.

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Growth factors such as EGF, bFGF and GDNF play an essential role in the ENS development and homeostasis. In vivo conditions which provide a reduction or absence of these factors promote the development of diseases such as intestinal agangliosis. Thus two models of in vitro culture that simulate the physiological condition (SM) and that of agangliosis (BM) was evaluated. ENS-derived cells (ENSc) were isolated from the myenteric plexus of the Sprague Dawley rats [Schaefer et al., 1997]. Particular attention was given to the regulation mechanisms mediated by TLR4 and Wnt signalling. At time of isolation, immunophenotypical characterization by flow cytometry showed the expression of stem cell (SOX2, NANOG, and CD34), neuronal and glial (p75, Nestin, GFAP) markers. Culturing in SM and BM showed a specific modulation of neuronal and glial differentiation and a greater responsiveness mediated by Frizzled 9 (SM) and TLR4 (BM) was observed. Moreover, a neuronal subpopulation co-expressed the receptors TLR4 and Frizzled-9 suggesting that this cell population may be involved in the maintenance of homeostasis and in the regulation of inflammatory processes. Furthermore, only SM cultures formed neurosphere-like structures. Wnt3a stimulation activated the canonical Wnt pathway through Frizzled-9 and qRT-PCR analysis demonstrated anti-inflammatory activity. In addition, a cross-talk between LPS/TLR4 and Wnt pathway was demonstrated by western blotting. Differentiation processes are also influenced by the extracellular matrix (ECM). In this study, the modulatory effect induced by ECM was evaluated assessing an in vitro model: ENS-derived cells cultured on a decellularized ECM of adult rat jejunum. Acellular matrixes (AMs) were provided using a modified enzyme detergent decellularization protocol [Meezan et al., 1975]. Histological study, SEM and quantification of residual DNA verified the complete decellularization. Immunofluorescence and western blotting demonstrated that the structural proteins such as collagen I, III , IV and laminin were preserved. After culturing ENSc on AMs for 7 and 14 days, the ECM demonstrated to influence the ENSc spatial organization, exerting a synergic effect with the factors present in the culture medium. In fact, only the AM cultures with SM, showed ganglion-like structures partially interconnected and positive for βIII tubulin. ENSc cultured on acellular matrix may represent a useful in vitro model for toxicological and pharmacological studies as well as a possible tissue scaffold in regenerative medicine.
E’ noto che i fattori di crescita quali EGF, bFGF e GDNF giocano un ruolo essenziale nello sviluppo e nell’omeostasi del sistema nervoso enterico (SNE). Condizioni in vivo che prevedono un calo o un’assenza del loro apporto, favoriscono lo sviluppo di patologie quali agangliosi intestinale. In questo lavoro di tesi, allestendo due modelli di coltura in vitro che simulano la condizione fisiologica (SM) e quella di agangliosi (BM) mediante coltura in presenza (SM) o meno di fattori di crescita (BM) è stata oggetto di studio la risposta differenziativa di cellule isolate da plesso mienterico di ratto Sprague Dawley (ENSc) [Schaefer et al., 1997]. In particolare, veniva prestata attenzione ai meccanismi di regolazione della risposta cellulare mediata dal segnale TLR4 e Wnt. Lo studio di caratterizzazione dell’immunofenotipo mediante citofluorimetria evidenziava nelle popolazioni estratte l’espressione di marcatori di staminalità (SOX2, Nanog e CD34) e di linea neuronale e gliale (p75, Nestina, GFAP). Inoltre, si evidenziava la presenza di una sottopolazione con caratteristiche neuronali che co-esprimeva i recettori TLR4 e Frizzled-9, suggerendo un ruolo nella regolazione del processo infiammatorio. La coltura in terreno SM e BM dimostrava di modulare in maniera specifica il differenziamento neuronale e gliale delle ENSc e di conferire una maggiore reattività mediata dal Frizzled 9 (coltura SM) e dal TLR4 (coltura BM). Inoltre, l’analisi di microscopia ottica evidenziava la formazione di strutture del tipo neurosfere solo nelle colture trattate con terreno standard. Lo stimolo indotto dal Wnt3a risultava efficace nell’attivare la via di segnale canonica di Wnt attraverso il recettore Frizzled 9 e, all’analisi di espressione genica mediante qRT-PCR, dimostrava un’attività di tipo anti-infiammatorio. Inoltre, mediante uno studio di western blotting, si dimostrava che la via pro-infiammatoria del TLR4 cross-reagiva con il segnale Wnt attivandolo. E’ noto che il processo differenziativo è fortemente condizionato dalla matrice extracellulare. In questo studio l’effetto modulatorio indotto dalla matrice sulla risposta differenziativa delle cellule ENSc è stato valutato utilizzando matrice acellularizzata (AM) di tessuto intestinale di ratto. La preparazione dello scaffold ha previsto 5 cicli ripetuti di decellularizzazione del trattamento modificato detergente enzimatico di Meezan [1975]. La completa decellularizzazione del tessuto veniva verificata mediante studio istologico, analisi di microscopia elettronica a scansione (SEM) e quantificazione del contenuto di DNA residuo. All’analisi di immunofluorescenza e western blotting, le proteine strutturali quali collagene I, III, IV e laminina risultavano preservate al termine della decellularizzazione. Dopo coltura per 7, 14 giorni delle cellule ENSc sulla matrice, AM dimostrava di condizionare l’organizzazione spaziale delle cellule ENSc esercitando un effetto specifico differenziativo in sinergia con i fattori di crescita. Infatti, solo le matrici mantenute in terreno SM mostravano una caratteristica organizzazione delle cellule ENSc in strutture interconnesse di tipo simil-gangliare esprimenti il marcatore neuronale βIII tubulina. Le colture di ENSc su matrice acellulare possono rappresentare un valido modello in vitro per studi tossicologici ed un possibile sostituto tessutale nella medicina rigenerativa.
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Dias, Neto Domingos Pedro Manuel. "The wnt/b-catenin signalling pathway and anterior posterior patterning in the vertebrate central nervous system." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368691.

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Hanson, Miranda Leah. "Prenatal cadmium exposure dysregulates sonic hedgehog and Wnt/beta-catenin signaling in the thymus resulting in immunomodulatory effects." Morgantown, W. Va. : [West Virginia University Libraries], 2009. http://hdl.handle.net/10450/10625.

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Thesis (Ph. D.)--West Virginia University, 2009.
Title from document title page. Document formatted into pages; contains vii, 250 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.
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Matzelle, Melissa M. "Inflammation Inhibits Osteoblast-Mediated Bone Formation in Rheumatoid Arthritis and Regulates the Wnt and BMP Signaling Pathways: A Dissertation." eScholarship@UMMS, 2012. https://escholarship.umassmed.edu/gsbs_diss/596.

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Osteoclast-mediated focal articular bone erosion is a hallmark of rheumatoid arthritis, a disease of inflammation-induced bone loss. Inflammation in the bone microenvironment enhances osteoclast differentiation leading to bone erosion. Simultaneously, inflammation also inhibits osteoblast-mediated bone formation, further contributing to the net loss of bone. Previous studies have shown a paucity of mature osteoblasts at eroded bone surfaces correlating with suppression of bone formation and upregulation of antagonists of the Wnt pathway, a signaling cascade essential for osteoblast lineage commitment. Despite these observations, the exact pathogenesis of impaired bone formation in the setting of inflammation is not clearly understood. This dissertation aims to delineate the mechanisms by which inflammation suppresses osteoblast differentiation and activity in inflammatory arthritis. Specifically, this research elucidates how inflammation-induced alterations in the Wnt and bone morphogenetic protein (BMP) osteogenic signaling pathways contribute to bone loss and formation at distinct inflammatory microenvironments within the bone. Secondly, the means by which cellular mediators, including lymphocytes and macrophages, facilitate bone erosion and formation was addressed. Taken together, the research in this dissertation underscores the relationship between inflammation-induced bone loss and alterations in osteogenic signaling. Using an innovative murine inflammatory arthritis model, this study definitively demonstrates that resolving inflammation promotes osteoblast-mediated bone formation. Repair of erosions correlates with upregulation of synovial expression of Wnt10b, a Wnt agonist, and downregulation of sFRP1 and sFRP2, Wnt antagonists. This work also directly evaluates the contribution of sFRP1 to inflammation-induced bone destruction. Furthermore, this research demonstrates that expression of BMP3, a negative regulator of BMP signaling, is upregulated in osteoblasts by IL-17, a pro-inflammatory cytokine. BMP3-expressing osteoblasts are also observed at erosion sites in murine arthritis. Lastly, evaluation of the mediators of inflammation-induced periosteal bone formation implicates BMP2 as a means by which inflammation may positively regulate osteoblast function. This dissertation further elucidates the role of T cells and macrophages in the erosion and formation processes, respectively. In the absence of lymphocytes, bone erosion occurred normally, demonstrating that RANKL-expressing lymphocytes are not absolutely required for the bone erosion. Preliminary studies also suggest that M2 macrophages are potential mediators of bone formation via the expression of BMP2. In conclusion, this dissertation explores the ability of inflammation to act as a rheostat, which controls the fate of bone by modulating not only osteoclast differentiation, but also osteogenic signaling pathways and cellular mediators in the bone microenvironment. The soluble mediators and cell types identified in this research highlight novel mechanisms by which inflammation may regulate osteoblast activity within the bone microenvironment. Collectively, these data imply that strict control of inflammation may be necessary in order to create an anabolic environment that preserves bone architecture in diseases of inflammation-induced bone loss.
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Books on the topic "Wnt System"

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Schulte, Gunnar, and Pawel Kozielewicz, eds. Pharmacology of the WNT Signaling System. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-85499-7.

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Hole, B. J. Assessment of a continuous miner wet-head system. Sudbury: HSE Books, 2000.

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Millett, Matthew. Demonstration reedbed filtration systems: At WWT Slimbridge and WWT Martin Mere. Slimbridge: Wildfowl and Wetlands Trust, 1997.

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Carr, David W. Outfall water quality from wet detention systems. Brooksville, Fla: Environmental Section, Resource Projects Department, Southwest Florida Water Management District, 1997.

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Calasanz. Creating the body you want: Calasanz martial arts system. Norwalk, Conn: Calasanz Martial Arts Pub., 2000.

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McCullar, Scott. Dewey Decimal System defeats Truman!: Library cartoons. Jefferson, N.C: McFarland, 1998.

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So you want to be a wizard. [Montréal, Québec]: Wizard Wow Fun Industries, 2017.

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Goldberg, Stephen. Four-minute neurologic exam.: (an answer to the "Neuro WNL" problem. Miami: Medmaster, 1999.

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The 4-minute neurologic exam: An answer to the "Neuro WNL" problem. Miami, FL: Medmaster, 1987.

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Great Britain. Department of Trade and Industry. and Great Britain. Small Business Service., eds. Less taxing tax: What small businesses want from the taxation system. [London]: Department of Trade and Industry, 2004.

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Book chapters on the topic "Wnt System"

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Yadav, Vikas, Njainday Jobe, Lubna Mehdawi, and Tommy Andersson. "Targeting Oncogenic WNT Signalling with WNT Signalling-Derived Peptides." In Pharmacology of the WNT Signaling System, 279–303. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/164_2021_528.

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Davidson, Gary. "LRPs in WNT Signalling." In Pharmacology of the WNT Signaling System, 45–73. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/164_2021_526.

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Sonavane, Pooja R., and Karl Willert. "Controlling Wnt Signaling Specificity and Implications for Targeting WNTs Pharmacologically." In Pharmacology of the WNT Signaling System, 3–28. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/164_2021_529.

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Hu, Yan, Chiara Ciminieri, Qianjiang Hu, Mareike Lehmann, Melanie Königshoff, and Reinoud Gosens. "WNT Signalling in Lung Physiology and Pathology." In Pharmacology of the WNT Signaling System, 305–36. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/164_2021_521.

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Katanaev, Vladimir L., Artem Blagodatski, Jiabin Xu, Yuri Khotimchenko, and Alexey Koval. "Mining Natural Compounds to Target WNT Signaling: Land and Sea Tales." In Pharmacology of the WNT Signaling System, 215–48. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/164_2021_530.

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Micka, Miroslav, and Vítězslav Bryja. "Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?" In Pharmacology of the WNT Signaling System, 117–35. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/164_2021_527.

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Inestrosa, Nibaldo C., Cheril Tapia-Rojas, Waldo Cerpa, Pedro Cisternas, and Juan M. Zolezzi. "WNT Signaling Is a Key Player in Alzheimer’s Disease." In Pharmacology of the WNT Signaling System, 357–82. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/164_2021_532.

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Kozielewicz, Pawel, Hannes Schihada, and Gunnar Schulte. "Employing Genetically Encoded, Biophysical Sensors to Understand WNT/Frizzled Interaction and Receptor Complex Activation." In Pharmacology of the WNT Signaling System, 101–15. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/164_2021_534.

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De Palma, Anna, and Giovanna Nalesso. "WNT Signalling in Osteoarthritis and Its Pharmacological Targeting." In Pharmacology of the WNT Signaling System, 337–56. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/164_2021_525.

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Hojjat-Farsangi, Mohammad, Ali Moshfegh, Johan Schultz, Martin Norin, Thomas Olin, Anders Österborg, and Håkan Mellstedt. "Targeting the Receptor Tyrosine Kinase ROR1 by Small Molecules." In Pharmacology of the WNT Signaling System, 75–99. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/164_2021_535.

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Conference papers on the topic "Wnt System"

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NAYAK, LOSIANA, RAJAT K. DE, and ABHIROOP DATTA. "PREDICTION OF SYSTEM STATES, ROBUSTNESS AND STABILITY OF THE HUMAN WNT SIGNAL TRANSDUCTION PATHWAY USING BOOLEAN LOGIC." In 15th International Symposium on Mathematical and Computational Biology. WORLD SCIENTIFIC, 2016. http://dx.doi.org/10.1142/9789813141919_0012.

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Winges, Johan, Thomas Rylander, Tomas McKelvey, Carl Petersson, Christian Ekman, and Lars-Ake Johansson. "System identification and tuning of WPT systems." In 2017 IEEE International Conference on Environment and Electrical Engineering and 2017 IEEE Industrial and Commercial Power Systems Europe (EEEIC / I&CPS Europe). IEEE, 2017. http://dx.doi.org/10.1109/eeeic.2017.7977544.

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Chenquan Hua, Changming Wang, and Yanfeng Geng. "Flow regime identification for wet gas flow based on WPT and RBFN." In 2009 IEEE International Conference on Intelligent Computing and Intelligent Systems (ICIS 2009). IEEE, 2009. http://dx.doi.org/10.1109/icicisys.2009.5357662.

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Card, R. W. "Economic Design of Hybrid Wet-Dry Cooling Systems." In ASME 2013 Power Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/power2013-98111.

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A hybrid wet-dry cooling system can be designed for a large combined-cycle power plant. A well-designed hybrid cooling system will provide reasonable net generation year-round, while using substantially less water than a conventional wet cooling tower. The optimum design for the hybrid system depends upon climate at the site, the price of power, and the price of water. These factors vary on a seasonal basis. Two hypothetical power plants are modeled, using state-of-the-art steam turbines and hybrid cooling systems. The plants are designed for water-constrained sites incorporating typical weather data, power prices, and water prices. The principles for economic designs of hybrid cooling systems are demonstrated.
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Leusch, Gregor, Evgeny Matusov, and Hermann Ney. "The RWTH system combination system for WMT 2009." In the Fourth Workshop. Morristown, NJ, USA: Association for Computational Linguistics, 2009. http://dx.doi.org/10.3115/1626431.1626441.

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Inaba, Sakano, Shirakawa, Miyazaki, Iwamura, Maeda, Mashino, Nagai, and Mori. "Sub-system power module for a 42V motor generator system [automotive applications." In IC's. IEEE, 2004. http://dx.doi.org/10.1109/wct.2004.239867.

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Luchaninov, A. I., D. V. Gretskih, A. V. Gomozov, V. A. Katrich, and M. V. Nesterenko. "Electrodynamic Approach to Designing WPT Systems with Accounting for Non-system Interactions." In 2019 IEEE 2nd Ukraine Conference on Electrical and Computer Engineering (UKRCON). IEEE, 2019. http://dx.doi.org/10.1109/ukrcon.2019.8879788.

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Tello, Alejandro D. "Qualification and Assessment of Subsea Insulation Systems." In ASME 2013 32nd International Conference on Ocean, Offshore and Arctic Engineering. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/omae2013-10987.

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As offshore oil and gas production continues to push into deeper waters, subsea production systems are challenged to manage the inherently higher operating temperatures and pressures. As a consequence of their direct exposure to seawater, subsea “wet” insulation systems on subsea trees, manifolds, and jumpers are amongst the most affected by this progression. Due to the significant thermal gradient between the production stream and subsea environment, subsea insulation systems are constantly trying to inhibit the natural heat transfer. In an effort preserve the operational integrity of the production system, the subsea insulation system maintains the production stream temperature above the hydrate formation and wax deposition temperatures. Thus, any failures such as cracks, disbondment, or hydrolysis, substantially influence the subsea system’s operational philosophy. As a result of ExxonMobil’s observed performance challenges with wet insulation systems, a thorough qualification program was initiated in 2007 to validate the performance of a wet insulation system under simulated service conditions. The qualification consisted of 3 test phases, including basic material property tests, simulated service tests, and an extended service test, for multiple insulation systems. This paper presents an overview of select subsea insulation failures, the qualification program, and subsequent assessment of key material properties, such as tensile strength/elongation, density, and hardness.
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Hong, Pan, and Zheng Yuan. "Vibration-Based Fault Diagnosis of Pump Using WPT." In ASME 2008 Fluids Engineering Division Summer Meeting collocated with the Heat Transfer, Energy Sustainability, and 3rd Energy Nanotechnology Conferences. ASMEDC, 2008. http://dx.doi.org/10.1115/fedsm2008-55291.

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A vibration-based fault diagnosis method of pump units based on wavelet packet transform (WPT) is proposed in this paper. Compared with Fourier transform (FT) and wavelet transform (WT), WPT can subdivide the whole time-frequency domain. It can perform signals with good time resolution at high frequency and vice versa. WPT is considered as a good tool to signal denoising, accounting for its perfect ability in decomposing and reconstructing signal and its characteristic of no redundancy and divulges after denoising. In addition, WPT modulus maximal coefficient provides a simple but accurate method in calculating the Lipschitz exponents, which is the measurement of signal singularity. According to the singularity analysis results of vibration signal, we can recognize the fault pattern of pump units. This paper makes a detail research on signal denoising and singularity analysis based on WPT. Taking the main shaft and thrust bearing vibration signal for example, the experimental results show that WPT is effectively in the fault diagnosis system of pump unit.
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Mostafa, Tarek M., Dai Bui, Aam Muharam, Reiji Hattori, and Aiguo Patrick Hu. "A Capacitive Power Transfer System with a CL Network for Improved System Performance." In 2018 IEEE Wireless Power Transfer Conference (WPTC). IEEE, 2018. http://dx.doi.org/10.1109/wpt.2018.8639497.

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Reports on the topic "Wnt System"

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Pidaparti, Sandeep, Charles W. White, and Nathan Weiland. Wet Cooling Tower Cooling System Spreadsheet Model for sCO2. Office of Scientific and Technical Information (OSTI), March 2020. http://dx.doi.org/10.2172/1608968.

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David Rencher. Reduction of Water Use in Wet FGD Systems. Office of Scientific and Technical Information (OSTI), June 2008. http://dx.doi.org/10.2172/941698.

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Searcy, K., M. Richardson, G. Blythe, D. Wallschlaeger, P. Chu, and C. Dene. Selenium Speciation and Management in Wet FGD Systems. Office of Scientific and Technical Information (OSTI), February 2012. http://dx.doi.org/10.2172/1040596.

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Elliott, D. C., L. J. Sealock, M. R. Phelps, G. G. Neuenschwander, and T. R. Hart. Development of a catalytic system for gasification of wet biomass. Office of Scientific and Technical Information (OSTI), August 1993. http://dx.doi.org/10.2172/10120451.

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Buelt, J. L. Mobile encapsulation and volume reduction system for wet low-level wastes. Office of Scientific and Technical Information (OSTI), August 1985. http://dx.doi.org/10.2172/5401671.

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Unknown. ENHANCED CONTROL OF MERCURY BY WET FLUE GAS DESULFURIZATION SYSTEMS. Office of Scientific and Technical Information (OSTI), June 2001. http://dx.doi.org/10.2172/794238.

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G. Blythe, B. Marsh, S. Miller, C. Richardson, and M. Richardson. ENHANCED CONTROL OF MERCURY BY WET FLUE GAS DESULFURIZATION SYSTEMS. Office of Scientific and Technical Information (OSTI), June 2001. http://dx.doi.org/10.2172/828035.

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Beitelman, Alfred D. REMR Management System - Coatings for Use on Wet or Damp Steel Surfaces. Fort Belvoir, VA: Defense Technical Information Center, December 1997. http://dx.doi.org/10.21236/ada341787.

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Branover, H., Y. Unger, A. El-Boher, and H. Schweitzer. Development of a wet vapor homogeneous liquid metal MHD power system. Final report. Office of Scientific and Technical Information (OSTI), September 1991. http://dx.doi.org/10.2172/10150340.

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Roberson, G. P., and D. C. Camp. Active source requirements for assay of sludge drums on the BIR WIT system. Office of Scientific and Technical Information (OSTI), April 1998. http://dx.doi.org/10.2172/641266.

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