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1
Bao, Xiuyu, Yiping Song, Tao Li, Shanshan Zhang, Lihua Huang, Shuya Zhang, Junting Cao, Xiaolin Liu, and Jianqin Zhang. "Comparative Transcriptome Profiling of Ovary Tissue between Black Muscovy Duck and White Muscovy Duck with High- and Low-Egg Production." Genes 12, no. 1 (December 31, 2020): 57. http://dx.doi.org/10.3390/genes12010057.
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The egg-laying rate is an important indicator for evaluating fertility of poultry. In order to better understand the laying mechanism of Muscovy ducks, gene expression profiles and pathways of ovarian tissues in high- and low-laying black (BH and BL) and white Muscovy ducks (WH and WL) during the peak production period were performed by using RNA-seq. The total number of reads produced for each ovarian sample ranged from 44,344,070 to 47,963,328. A total of 113, 619 and 87 differentially expressed genes (DEGs) were identified in BH-vs-WH, BL-vs-BH and BL-vs-WL, respectively. Among them, 54, 356 and 49 genes were up regulated and 59, 263 and 38 genes were down regulated. In addition, there were only 10 up-regulated genes in WL-vs-WH. In the comparison of DEGs in black and white Muscovy ducks, two co-expressed DEG genes were detected between BH-vs-WH and BL-vs-WL and seven DEGs were co-expressed between BL-vs-BH and WL-vs-WH. The RNA-Seq data were confirmed to be reliable by qPCR. Numerous DEGs known to be involved in ovarian development were identified, including TGFβ2, NGFR, CEBPD, CPEB2, POSTN, SMOC1, FGF18, EFNA5 and SDC4. Gene Ontology (GO) annotations indicated that DEGs related to ovarian development were mainly enriched in biological processes of “circadian sleep/wake cycle process,” “negative regulation of transforming growth factor-β secretion,” “positive regulation of calcium ion transport” in BH-vs-WH and “cell surface receptor signaling pathway,” “Notch signaling pathway” and “calcium ion transport” in BL-vs-BH. Besides, “steroid biosynthetic process,” “granulosa cell development” and “egg coat formation” were mainly enriched in BL-vs-WL and “reproduction,” “MAPK cascade” and “mitotic cell cycle” were mainly enriched in WL-vs-WH. KEGG pathway analysis showed that the PI3K-Akt signaling pathway and ovarian steroidogenesis were the most enriched in Muscovy duck ovary transcriptome data. This work highlights potential genes and pathways that may affect ovarian development in Muscovy duck.
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Ryan, Alice S., Barbara J. Nicklas, and Karen E. Dennis. "Aerobic exercise maintains regional bone mineral density during weight loss in postmenopausal women." Journal of Applied Physiology 84, no. 4 (April 1, 1998): 1305–10. http://dx.doi.org/10.1152/jappl.1998.84.4.1305.
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This study examines the effects of weight loss by caloric restriction (WL) and aerobic exercise plus weight loss (AEx+WL) on total and regional bone mineral density (BMD) in older women. Healthy, postmenopausal women [age 63 ± 1 (SE) yr] not on hormone-replacement therapy underwent 6 mo of WL ( n = 15) consisting of dietary counseling one time per week with a caloric deficit (250–350 kcal/day) or AEx+WL ( n = 15) consisting of treadmill exercise three times per week in addition to the weight loss. Maximal aerobic capacity increased only in the AEx+WL group ( P < 0.001). Body weight, percent fat, and fat mass decreased similarly in both groups ( P < 0.005), with no changes in fat-free mass. Total body BMD (by dual-energy X-ray absorptiometry) decreased in both groups ( P < 0.05). Femoral neck, Ward’s triangle, and greater trochanter BMD decreased in the WL group ( P ≤ 0.05) but were not significantly different after AEx+WL. L2–L4BMD did not significantly change in either group. Thus WL and AEx+WL both result in losses of total body BMD; however, AEx+WL appears to prevent the loss in regional BMD seen with WL alone in healthy, older women. This suggests that the addition of exercise to weight-loss programs may reduce the risk for bone loss.
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Beal, Dominic, Sean Graham, Brett Van Dam, Gregory Lyng, and Stephen Sonis. "Endoscopy and FACS analysis in classic and humanized murine models of GVHD (HUM1P.316)." Journal of Immunology 194, no. 1_Supplement (May 1, 2015): 52.41. http://dx.doi.org/10.4049/jimmunol.194.supp.52.41.
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Abstract It is perplexing that standard murine GVHD model endpoints of weight loss (WL) and composite clinical changes (CCC) often fail to respond to standard forms of therapy (tacrolimus and anti-p40 monoclonal antibody). To improve on the translatability of GVHD models we evaluated serial endoscopy as a means to directly assess injury and serial blood counts to predict onset of severe disease. Two models were used. CD3+ cells were magnetically depleted from bone marrow harvested from male Balb/c mice. Varying numbers of (depleted) bone marrow and splenocytes were then injected IV into lethally irradiated (8Gy) C57Bl/6 hosts. Serial endoscopy performed after GVHD onset (~2 weeks post transfer) demonstrated changes which strongly correlated with WL and CCC (R2=-0.84 and 0.79). Next we induced GVHD in a humanized model by the adoptive transfer of human PBMCs into severely immunocompromised mice (NSG). Serial blood draws demonstrated a strong correlation between peripheral blood human T cell (PBTC) numbers and WL and CCC (R2=-0.85 and 0.67 on day 42) suggesting that assessment of PBTC numbers may be applicable to the evaluation of therapies directly targeting these cell types. Day 7 human PBTC counts predicted final WL and CCC scores with high correlation (R2=-0.86 and 0.90) indicating that this metric can be used to stratify animals into groups prior to the onset of observable disease and treatment.
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Nicklas, B. J., E. M. Rogus, and A. P. Goldberg. "Exercise blunts declines in lipolysis and fat oxidation after dietary-induced weight loss in obese older women." American Journal of Physiology-Endocrinology and Metabolism 273, no. 1 (July 1, 1997): E149—E155. http://dx.doi.org/10.1152/ajpendo.1997.273.1.e149.
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Weight loss (WL) by hypocaloric diet decreases adipocyte lipolysis and fat oxidation, adaptations that might predispose individuals to regain weight. Our hypothesis was that the addition of endurance exercise (EX) to dietary-induced WL (6 mo; 250-350 kcal/day deficit) would prevent declines in abdominal (ABD) and gluteal (GLT) adipocyte lipolysis and fat oxidation in obese older women. At baseline, the WL (n = 9) and WL+EX (n = 11) groups had similar body composition, fat distribution, aerobic fitness (VO2max), and resting fat metabolism. Reductions in body weight (WL = 11%, WL+EX = 8%), percent body fat, and intra-abdominal fat area with the interventions were similar in both groups, but VO2max increased (9%, P < 0.01) only in the WL+EX group. Basal and adrenergic receptor- and postreceptor-stimulated lipolysis in ABD and GLT adipocytes decreased (20-70%, P < 0.05) in the WL group but did not change in the WL+EX group. Fat oxidation decreased (38%, P < 0.05) in the WL group but not in the WL+EX group. The changes in fat oxidation and GLT lipolysis differed significantly between groups. Fat oxidation correlated positively with ABD and GLT adipocyte basal lipolysis at baseline (r = 0.45 and r = 0.53, P < 0.05), and the changes in fat oxidation with the interventions correlated positively with changes in ABD and GLT adipocyte basal lipolysis (r = 0.50 and r = 0.42. P < 0.05) in the entire group of women. These results indicate that exercise counteracts the decline in fat oxidation with WL, in part by maintaining adipocyte lipolytic responsiveness in some weight-reduced postmenopausal women.
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Szabo-Reed, Amanda Nicole, Richard Washburn, Laura Martin, Cary Savage, and Joseph Donnelly. "4220 Cognitive Function and Relationships with Intervention Dropout, Adherence and Weight Loss." Journal of Clinical and Translational Science 4, s1 (June 2020): 25. http://dx.doi.org/10.1017/cts.2020.115.
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OBJECTIVES/GOALS: Greater cognitive function (CF) is associated with adherence to prescription medications, better program adherence and weight loss (WL) following bariatric surgery. The purpose of this study was to evaluate the association between baseline CF, intervention dropout, adherence and 3-month WL. METHODS/STUDY POPULATION: 107 (Mage = 40.9 yrs.), overweight/obese (BMI = 35.6 kg/m2) men (N = 17) and women (N = 90) completed a 3-mo. WL intervention. Participants were asked to attend weekly behavioral sessions, comply with a reduced calorie diet and complete 100 min of moderate intensity physical activity (PA)/wk. CF tasks including Flanker (attention), Stroop (Executive control) and working memory, body weight and cardiovascular fitness (covariate) were assessed at baseline and 3-mos. Session attendance, adherence to PA and diet prescriptions and number of off-diet episodes were recorded weekly. RESULTS/ANTICIPATED RESULTS: Results indicated that attention was positively correlated with session attendance (p = 0.016), adherence to the diet (p < 0.01) and PA (p = 0.023). Executive control was positively correlated with WL (p = 0.042). Working memory (two tasks) was also positively correlated with WL (p = .017 and p = .025). Analysis of variance (ANOVA) indicated that baseline attention (p = .012) was positively related to WL and negatively associated with drop out (p < .05). Hierarchical linear regression showed executive control (p = .036, R2 = .054) and working memory (p = .013, R2 = .073 and p = .017, R2 = .068) were associated with WL when controlling for fitness. DISCUSSION/SIGNIFICANCE OF IMPACT: These results suggest that stronger baseline attention is associated with completion of a 3-mo. WL intervention. Executive control and working memory are associated with amount of WL achieved. Additional, larger and longer trials to assess the role of baseline CF on WL and evaluating the impact of interventions designed to improve CF on WL are indicated.
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Zralý, Z., B. Písaříková, M. Trčková, M. Doležal, J. Thiemel, J. Simeonovová, and M. Jůzl. "Replacement of soya in pig diets with white lupine cv. Butan." Czech Journal of Animal Science 53, No. 10 (October 16, 2008): 418–30. http://dx.doi.org/10.17221/353-cjas.
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The purpose of the present study was to evaluate the effect of soya replacement (50 or 100%) with whole (WL) or dehulled seeds (DL) of white lupine cv. Butan in the diets for market pigs. The experiment was performed on 50 pigs in equal numbers of barrows and gilts with the initial mean body weight (BW) of 18.3 ± 2.1 kg, fed isonitrogenous and isoenergetic diets for 100 days. In the experimental starter pigs (18 to 35 kg BW), the mean daily body weight gain (BWG) was 0.61 to 0.64 kg and was insignificantly lower by 1.5 to 6.2% in comparison with the pigs fed the control soya diet (SBM). The diet intake was also lower by 5.4 to 6.8% and could result from a higher content of crude fibre. In the grower and finisher diets, no side effect of high lupine levels on the feed intake was evident. The intake of DL diets was higher in comparison with the soya diet. The feed efficiency of the finisher diets was insignificantly higher (<I>P</I> > 0.05) for experimental diets (WL 50, WL 100, DL 100) in contrast to the control diet. The differences among diets containing WL or DL seeds were insignificant. During the experiment, no adverse effect of lupine on the health of pigs was observed and no significant differences in the parameters of market pig meat, nutrition quality of meat and sensory analysis were detected. The inclusion of lupine in diets resulted in a significantly lower n-6/n-3 ratio of polyunsaturated fatty acids (<I>P</I> < 0.01) in meat lipids (5.15 to 5.33) in comparison with soya (8.75). It follows from the obtained results that the tested lupine variety seeds are a source of high-quality protein that can be an alternative to soya in the diets for market pigs.
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Unick, Jessica L., Christine A. Pellegrini, Shira I. Dunsiger, Kathryn E. Demos, J. Graham Thomas, Dale S. Bond, Robert H. Lee, Jennifer Webster, and Rena R. Wing. "An Adaptive Telephone Coaching Intervention for Patients in an Online Weight Loss Program." JAMA Network Open 7, no. 6 (June 7, 2024): e2414587. http://dx.doi.org/10.1001/jamanetworkopen.2024.14587.
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ImportanceWeight loss (WL) during the first month of a behavioral program is associated with longer-term WL. Testing of translatable and adaptive obesity programs is needed.ObjectiveTo compare brief, extended, and no telephone coaching for individuals with suboptimal response (ie, 1-month WL &lt;4%) within an online WL program.Design, Setting, and ParticipantsThis randomized clinical trial with enrollment between March 2019 and April 2022 (data collection completed May 2023) was conducted at an academic research center in the US. Eligible participants included adults aged 18 to 70 years with daily access to internet and a body mass index between 25 and 45.InterventionsAll participants received an automated online WL program (4 months) and WL maintenance program (8 months), consisting of video lessons, self-monitoring, and personalized feedback. Participants were randomized, such that individuals with suboptimal response received either brief telephone coaching (3 calls during weeks 5-8), extended telephone coaching (12 calls during weeks 5-16), or no coaching (control). Coaching included education, problem solving, and goal setting, and promoted engagement with the online program.Main Outcomes and MeasuresThe primary outcomes were percent weight change and proportion of participants achieving 5% or greater WL at 4 and 12 months. A priori hypotheses for WL were that WL for extended coaching would be greater than for brief coaching, and both extended and brief coaching would be greater than no coaching (control). A longitudinal mixed-effects model with participant-specific intercept was used to examine intervention effects on percent WL at 4 and 12 months. Secondary analyses focused on program engagement and cost/kilogram of WL.ResultsThe study included a total of 437 participants who reported WL at 1 month (mean [SD] age, 50.8 [11.4] years; mean [SD] BMI, 34.6 [5.0]; 305 female [69.8%] and 132 male [30.2%]) with 148 randomized to extended coaching, 143 assigned to brief coaching, and 146 assigned to the control group. Of all participants, 346 (79.2%) were considered to have a suboptimal response. WL at 4 months was significantly greater in the extended coaching group (mean [SD] WL, −7.0% [5.1%]) and brief coaching group (mean [SD] WL, −6.2% [4.7%]) vs the control group (mean [SD] WL, −4.5% [4.7%]) (P &lt; .001). Similarly, the proportion of participants achieving 5% or greater WL at 4 months was greater in the extended coaching group (89 participants [65.9%]) and brief coaching group (77 participants [58.5%]) vs control group (46 participants [36.5%]) (P &lt; .001). At 12 months, a similar pattern was observed for achievement of 5% WL or greater (extended coaching, 63 participants [48.1%]; brief coaching, 58 participants [45.9%]; control, 38 participants [32.8%]; P = .03). Percent WL at 12 months was significantly higher in extended coaching vs control (mean [SD] WL for extended coaching, −5.5% [6.7%]; mean [SD] WL for control, −3.9% [7.4%]; P = .03) but not for brief coaching (mean [SD] WL, −4.9% [6.1%]).Both the brief and extended coaching groups watched more lessons and self-monitored on more days compared with the control group. The cost per additional kilogram of WL, beyond that of the control group, was $50.09 for brief coaching and $92.65 for extended coaching.Conclusions and RelevanceIn this randomized clinical trial testing an adaptive intervention, the provision of coaching for individuals with suboptimal response improved WL and was cost-effective; further testing in clinical settings (eg, health care systems) is warranted.Trial RegistrationClinicalTrials.gov Identifier: NCT03867981
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Zhao, Xiaojun, Peize Lyu, Shenqin Fang, Shaohao Li, Xiaoxuan Tu, Penghe Ren, Dian Liu, Lyuming Chen, Lairong Xiao, and Sainan Liu. "Microstructure and Wear Behavior of Ti-xFe-SiC In Situ Composite Ceramic Coatings on TC4 Substrate from Laser Cladding." Materials 17, no. 1 (December 24, 2023): 100. http://dx.doi.org/10.3390/ma17010100.
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Titanium alloys are widely used in various structural materials due to their lightweight properties. However, the low wear resistance causes significant economic losses every year. Therefore, it is necessary to implement wear-resistant protection on the surface of titanium alloys. In this study, four types of in situ composite ceramic coatings with two-layer gradient structures were prepared on a Ti-6Al-4V (TC4) substrate using laser cladding. In order to reduce the dilution rate, a transition layer (Ti-40SiC (vol.%)) was first prepared on TC4 alloy. Then, a high-volume-fraction in situ composite ceramic working layer (Ti-xFe-80SiC (vol.%)) with different contents of Fe-based alloy powder (x = 0, 5, 10 and 15 vol.%) was prepared. The working surface of Ti-40SiC (TL) exhibited a typical XRD pattern of Ti, TiC, Ti5Si3, and Ti3SiC2. In comparison, both Ti-80SiC (WL-F0) and Ti-5Fe-80SiC (WL-F5) exhibited similar phase compositions to the TL coating, with no new phase identified in the coatings. However, the TiFeSi2 and SiC phases were presented in Ti-10Fe-80SiC (WL-F10) and Ti-15Fe-80SiC (WL-F15). It is proven that the addition of the Fe element could regulate the in situ reaction in the original Ti-Si-C ternary system to form the new phases with high hardness and good wear resistance. The hardness of the WL-F15 (1842.9 HV1) is five times higher than that of the matrix (350 HV1). Due to the existence of self-lubricating phases such as Ti5Si3 and Ti3SiC2, a lubricating film was presented in the WL-F0 and WL-F5 coatings, which could block the further damage of the friction pair and enhance the wear resistance. Furthermore, a wear-transition phenomenon was observed in the WL-F10 and WL-F15 coatings, which was similar to the friction behavior of structural ceramics. Under the load of 10 N and 20 N, the wear volume of WL-F15 coating is 5.2% and 63.7% of that in the substrate, and the depth of friction of WL-15 coating is only 14.4% and 80% of that in the substrate. The transition of wear volume and depth can be attributed to the wear mechanism changing from oxidation wear to adhesive wear.
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Rowland, IC, MG Mason, and J. Hamblin. "Effect of lupins and wheat on the yield of subsequent wheat crops grown at several rates of applied nitrogen." Australian Journal of Experimental Agriculture 28, no. 1 (1988): 91. http://dx.doi.org/10.1071/ea9880091.
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The responses of wheat to various rates of application of nitrogen fertiliser were compared following lupins (WL) or wheat (WW) in the previous year. Results covered 10 sites and trials were carried out between 1979 and 1984. giving 26 site-year comparisons. The trials were on sandy or duplex (sand over clay) soils. The overall yield of WL was greater than WW on 21 occasions (significant in 10 cases, P < 0.05), less than WW on 2 occasions (both significantly) and there was no difference on 3 occasions. When no nitrogen was applied the advantage of WL was 41% (WL 1.20 t/ha and WW 0.85 t/ha). The response to nitrogen differed between trials; over all trials a quadratic model best described the responses. There were significant interactions between rotation and nitrogen rate in 10 comparisons. In 4 of these cases, response to nitrogen with WW was greater than with WL and these response curves approached I another but did not meet, indicating that both residual nitrogen from the lupins and some other benefit from the lupins were involved. In 5 cases the greater response on WW resulted in convergence with the WL response curve, suggesting that residual nitrogen explained all of the benefit of lupins. In these cases the amount ofnitrogen fertiliser required to bring the yield of WW to that of the WL without nitrogen ranged from 20 to 47 kg N/ha, with a mean of 37 kg N/ha. Parallel response curves were observed In 12 cases, indicating involvement of factors other than residual nitrogen in the response to lupins, e.g. disease cleaning effects or slow release of nitrogen throughout the season. The type of response could not be related to particular site characteristics. When quadratic coefficients were averaged to give 'average response curves', similar rates of applied nitrogen were required for maximum yields in both WW and WL, and the maximum yields were 1.23 t/ha for WW and 1.41 t/ha for WL. The average advantage of WL over WW, in the absence of nitrogen fertiliser. was 350 kg/ha.
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Houston, Denise, Rebecca Neiberg, Shyh-Huei Chen, Michael Miller, Dalane Kitzman, W. Rejeski, Steve Messier, and Barb Nicklas. "PHYSICAL ACTIVITY AND WEIGHT LOSS MAINTENANCE IN OLDER ADULTS: LONG-TERM FOLLOW-UP DATA FROM FIVE RANDOMIZED TRIALS." Innovation in Aging 7, Supplement_1 (December 1, 2023): 390. http://dx.doi.org/10.1093/geroni/igad104.1291.
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Abstract Intentional weight loss (WL) in older adults is controversial as it may accelerate age-related muscle and bone loss, even if weight is regained. Current WL guidelines recommend physical activity (PA) for the maintenance of WL. However, whether participants who maintain WL have higher PA following randomized controlled trials (RCTs) of WL and PA is unknown. We examined PA among older adults from five WL and PA RCTs. Participants were invited to return for a follow-up visit 5-15 yrs after RCT completion (mean, 9.1 yrs). Among the 632 participants alive at long-term follow-up, 326 completed a follow-up visit (mean±SD age and BMI at randomization, 67.5±4.2 yrs and 33.8±4.9 kg/m2; 70% women). Weight change from baseline to long-term follow-up was assessed and participants categorized as weight gainers (>3%, 16%), weight maintainers (±3%, 32%), small weight losers (3-<10%, 28%), and large weight losers (>10%, 25%). Self-reported (CHAMPS) and objective (ActivPAL worn for 7 days) PA were assessed at long-term follow-up. Differences in PA by weight change groups were examined using mixed effects models adjusted for age, sex, race, WL assignment, time and study (as a random effect). There were no differences in self-reported PA by weight change group (all p’s>0.0.08). Objectively-measured steps per day (p=0.06) and stepping time (p=0.04) were marginally significant between groups, with large weight losers having greater values compared to weight gainers (mean: 4915 vs. 3790 steps/day and 70.8 vs. 55.1 minutes/day, respectively; p<0.05). Among those who returned at long-term follow-up, objectively measured PA was greater among large weight losers.
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Yoshida, Naohisa, Yuji Naito, Takaaki Murakami, Ryohei Hirose, Kiyoshi Ogiso, Yutaka Inada, Osamu Dohi, et al. "Linked color imaging improves the visibility of colorectal polyps: a video study." Endoscopy International Open 05, no. 06 (June 2017): E518—E525. http://dx.doi.org/10.1055/s-0043-105495.
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Abstract Background/study aim Linked color imaging (LCI) by a laser endoscope (Fujifilm Co, Tokyo, Japan) is a novel narrow band light observation. In this study, we aimed to investigate whether LCI could improve the visibility of colorectal polyps using endoscopic videos. Patients and methods We prospectively recorded videos of consecutive polyps 2 – 20 mm in size diagnosed as neoplastic polyps. Three videos, white light (WL), blue laser imaging (BLI)-bright, and LCI, were recorded for each polyp by one expert. After excluding inappropriate videos, all videos were evaluated in random order by two experts and two non-experts according to a published polyp visibility score from four (excellent visibility) to one (poor visibility). Additionally, the relationship between polyp visibility scores in LCI and various clinical characteristics including location, size, histology, morphology, and preparation were analyzed compared to WL and BLI-bright. Results We analyzed 101 colorectal polyps (94 neoplastic) in 66 patients (303 videos). The mean polyp size was 9.0 ± 8.1 mm and 54 polyps were non-polypoid. The mean polyp visibility scores for LCI (2.86 ± 1.08) were significantly higher than for WL and BLI-bright (2.53 ± 1.15, P < 0.001; 2.73 ± 1.47, P < 0.041). The ratio of poor visibility (score 1 and 2) was significantly lower in LCI for experts and non-experts (35.6 %, 33.6 %) compared with WL (49.6 %, P = 0.015, 50.5 %, P = 0.046). The polyp visibility scores for LCI were significantly higher than those for WL for all of the factors. With respect to the comparison between BLI-bright and WL, the polyp visibility scores for BLI-bright were not higher than WL for right-sided location, < 10 mm size, sessile serrated adenoma and polyp histology, and poor preparation. For those characteristics, LCI improved the lesions with right-sided location, SSA/P histology, and poor preparation significantly better than BLI. Conclusions LCI improved polyp visibility compared to WL for both expert and non-expert endoscopists. It is useful for improving polyp visibility in any location, any size, any morphology, any histology, and any preparation level.Study registration: UMIN000013770
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Shoshi, Ayumu, Naoto Harada, Kazuki Tokuda, Yoshihiro Kawasaki, Hayao Yamasaki, Asako Sato, Mitsuki Omura, Masayuki Yamaguchi, Kengo Tachihara, and Masahiro N. Machida. "Ring Gap Structure around Class I Protostar WL 17." Astrophysical Journal 961, no. 2 (January 30, 2024): 228. http://dx.doi.org/10.3847/1538-4357/ad12b5.
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Abstract WL 17 is a Class I object and was considered to have a ring–hole structure. We analyzed the structure around WL 17 to investigate the detailed properties of this object. We used Atacama Large Millimeter/submillimeter Array archival data, which have a higher angular resolution than previous observations. We investigated the WL 17 system with the 1.3 mm dust continuum and 12CO and C18O (J = 2–1) line emissions. The dust continuum emission showed a clear ring structure with inner and outer edges of ∼11 and ∼21 au, respectively. In addition, we detected an inner disk of <5 au radius enclosing the central star within the ring, the first observation of this structure. Thus, WL 17 has a ring–gap structure, not a ring–hole structure. We did not detect any marked emission in either the gap or inner disk, indicating that there is no sign of a planet, circumplanetary disk, or binary companion. We identified the source of both blueshifted and redshifted outflows based on the 12CO emission, which is clearly associated with the disk around WL 17. The outflow mass ejection rate is ∼3.6 × 10−7 M ⊙ yr−1 and the dynamical timescale is as short as ∼104 yr. The C18O emission showed that an inhomogeneous infalling envelope, which can induce episodic mass accretion, is distributed in the region within ∼1000 au from the central protostar. With these new findings, we can constrain the scenarios of planet formation and dust growth in the accretion phase of star formation.
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Johnstone, Alexandra M., Gerald E. Lobley, Graham W. Horgan, David M. Bremner, Claire L. Fyfe, Philip C. Morrice, and Garry G. Duthie. "Effects of a high-protein, low-carbohydrate v. high-protein, moderate-carbohydrate weight-loss diet on antioxidant status, endothelial markers and plasma indices of the cardiometabolic profile." British Journal of Nutrition 106, no. 2 (April 27, 2011): 282–91. http://dx.doi.org/10.1017/s0007114511000092.
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There are concerns that weight-loss (WL) diets based on very low carbohydrate (LC) intake have a negative impact on antioxidant status and biomarkers of cardiovascular and metabolic health. Obese men (n 16) participated in a randomised, cross-over design diet trial, with food provided daily, at approximately 8·3 MJ/d (approximately 70 % of energy maintenance requirements). They were provided with two high-protein diets (30 % of energy), each for a 4-week period, involving a LC (4 % carbohydrate) and a moderate carbohydrate (MC, 35 % carbohydrate) content. Body weight was measured daily, and weekly blood samples were collected. On average, subjects lost 6·75 and 4·32 kg of weight on the LC and MC diets, respectively (P < 0·001, sed 0·350). Although the LC and MC diets were associated with a small reduction in plasma concentrations of retinol, vitamin E (α-tocopherol) and β-cryptoxanthin (P < 0·005), these were still above the values indicative of deficiency. Interestingly, plasma vitamin C concentrations increased on consumption of the LC diet (P < 0·05). Plasma markers of insulin resistance (P < 0·001), lipaemia and inflammation (P < 0·05, TNF-α and IL-10) improved similarly on both diets. There was no change in other cardiovascular markers with WL. The present data suggest that a LC WL diet does not impair plasma indices of cardiometabolic health, at least within 4 weeks, in otherwise healthy obese subjects. In general, improvements in metabolic health associated with WL were similar between the LC and MC diets. Antioxidant supplements may be warranted if LC WL diets are consumed for a prolonged period.
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Cha, Sangjun, and M. James Jee. "MAximum-entropy ReconStruction (MARS): A New Strong-lensing Reconstruction Algorithm for the JWST Era." Proceedings of the International Astronomical Union 18, S381 (December 2022): 102–5. http://dx.doi.org/10.1017/s1743921323004015.
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AbstractThe MAximum-entropy ReconStruction (MARS) method is a free-form strong-lensing (SL) reconstruction algorithm, which adopts the maximum cross-entropy as a regularization. MARS shows remarkable convergence of multiple images in both source (∼0.”02) and image planes (∼0.”05 – 0.”1) while suppressing spurious fluctuations. Although the reconstruction requires a large number of free parameters exceeding ∼19,000, our implementation through PyTorch can obtain the reconstruction within hours. From our test using the publicly available synthetic clusters, we have verified that the reconstructed radial mass profiles are consistent with the truth within 1 percent. This makes MARS one of the best-performing SL reconstruction methods. We apply MARS to the six Hubble Frontier Fields clusters and present new mass reconstruction results. We also reconstruct a mass model of Abell 2744 using both weak-lensing (WL) and SL data from the JWST observations, with the largest dataset of Abell 2744, including 286 SL multiple images and ∼350 arcmin−2 WL constraints.
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Cha, Sangjun, Kim HyeongHan, Zachary P. Scofield, Hyungjin Joo, and M. James Jee. "Precision MARS Mass Reconstruction of A2744: Synergizing the Largest Strong-lensing and Densest Weak-lensing Data Sets from JWST." Astrophysical Journal 961, no. 2 (January 25, 2024): 186. http://dx.doi.org/10.3847/1538-4357/ad0cbf.
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Abstract We present a new high-resolution free-form mass model of A2744 that combines both weak-lensing (WL) and strong-lensing (SL) data sets from JWST. The SL data set comprises 286 multiple images, presenting the most extensive SL constraint to date for a single cluster. The WL data set, employing photo-z selection, yields a source density of ∼ 350 arcmin − 2 , marking the densest WL constraint ever. The combined mass reconstruction enables the highest-resolution mass map of A2744 within the ∼1.8 Mpc × 1.8 Mpc reconstruction region to date, revealing an isosceles triangular structure with two legs of ∼1 Mpc and a base of ∼0.6 Mpc. Although our algorithm, which is called MAximum-entropy ReconStruction (MARS), is entirely blind to the cluster galaxy distribution, the resulting mass reconstruction traces the brightest cluster galaxies remarkably well. The five strongest mass peaks coincide with the five most luminous cluster galaxies within ≲2″. We do not detect any unusual mass peaks that are not traced by the cluster galaxies, unlike the findings in previous studies. Our mass model shows the smallest scatter of SL multiple images in both source (∼0.″05) and image (∼0.″1) planes, which is lower than in previous studies by a factor of ∼4. Although MARS represents the mass field with an extremely large number of free parameters (∼300,000), it converges to a solution within a few hours because we use a deep-learning technique. We make our mass and magnification maps publicly available.
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Iacucci, M., R. Cannatelli, T. L. Parigi, A. Buda, N. Labarile, O. M. Nardone, G. E. Tontini, et al. "OP16 The first virtual chromoendoscopy artificial intelligence system to detect endoscopic and histologic remission in Ulcerative Colitis." Journal of Crohn's and Colitis 16, Supplement_1 (January 1, 2022): i017—i018. http://dx.doi.org/10.1093/ecco-jcc/jjab232.015.
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Abstract Background Endoscopic and histologic activity are important therapeutic targets in ulcerative colitis (UC). The Paddington International Virtual ChromoendoScopy ScOre (VCE-PICaSSO)1 demonstrated that enhanced visualisation of subtle mucosal and vascular inflammatory changes correlated strongly with histology. However, without adequate training, the subjective evaluation of white light (WL) and VCE endoscopic scores varies between observers. We aimed to develop an artificial intelligence (AI) system for objective assessment of endoscopic disease activity and predict histology related to both white light and VCE videos. Methods 469 endoscopy videos (48512 frames) from 235 patients representative of all grades of inflammation, from our prospective PICaSSO multicentre study1 were used to develop a convolutional neural network (CNN). 316 videos were divided into training (254) and validation (62) sets. 153 additional videos (78 patients) were used as test cohort. The videos were edited to separate clips with WL and with VCE, and assessed using Ulcerative Colitis Endoscopic Index of Severity (UCEIS) and PICaSSO, respectively. The classification stage of a pre-trained ResNet50 CNN classifier was trained to predict the healing or active inflammation on video frames. One network was trained to predict endoscopic remission (ER) as UCEIS≤1 from WL frames, and a second network was trained to predict PICaSSO≤3 from VCE. Histological remission (HR) was defined as Robarts Histological Index (RHI) ≤3 with no neutrophils in lamina propria or epithelium. Results In the validation cohort, our system predicted ER (UCEIS ≤1) in WL videos with 82% sensitivity (Se), 94% specificity (Sp) and an area under the ROC curve (AUROC) of 0.92. For the detection of remission in VCE videos (PICaSSO ≤3) Se was 74%, Sp 95%, and AUROC 0.95. In the testing cohort of independent videos, the diagnostic performance for both cut offs of ER remained similar. Our system also had an excellent diagnostic performance for the prediction of HR in the validation set, with Se, Sp, and Accuracy of 92%, 83%, and 85% respectively, using VCE, and 83%, 87%, and 86% respectively, with WL. In the testing set performance declined modestly while remaining good. Of note, the algorithm’s prediction of histology was similar with VCE and WL videos. Table 1 Table 2 Conclusion Our AI system accurately recognize endoscopic remission in videos and predict histological remission equally well. This is the first AI model developed to analyse inflammation and endoscopic remission in VCE through the PICaSSO score, and the first multi-domain system providing a complete endoscopic and histologic assessment. Reference 1. Iacucci et al. Gastroenterology 2021
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Liu, Xuexi, Hua Chen, Weiping Jiang, Ruijie Xi, Wen Zhao, Chuanfeng Song, and Xingyu Zhou. "Modeling and Assessment of GPS/Galileo/BDS Precise Point Positioning with Ambiguity Resolution." Remote Sensing 11, no. 22 (November 18, 2019): 2693. http://dx.doi.org/10.3390/rs11222693.
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Multi-frequency and multi-GNSS integration is currently becoming an important trend in the development of satellite navigation and positioning technology. In this paper, GPS/Galileo/BeiDou (BDS) precise point positioning (PPP) with ambiguity resolution (AR) are discussed in detail. The mathematical model of triple-system PPP AR and the principle of fractional cycle bias (FCB) estimation are firstly described. With the data of 160 stations in Multi-GNSS Experiment (MGEX) from day of year (DOY) 321-350, 2018, the FCBs of the three systems are estimated and the experimental results show that the range of most GPS wide-lane (WL) FCB is within 0.1 cycles during one month, while that of Galileo WL FCB is 0.05 cycles. For BDS FCB, the classification estimation method is used to estimate the BDS FCB and divide it into GEO and non-GEO (IGSO and MEO) FCB. The variation range of BDS GEO WL FCB can reach 0.5 cycles, while BDS non-GEO WL FCB does not exceed 0.1 cycles within a month. However, the accuracies of GPS, Galileo, and BDS non-GEO narrow-lane (NL) FCB are basically the same. In addition, the number of visible satellites and Position Dilution of Precision (PDOP) values of different combined systems are analyzed and evaluated in this paper. It shows that the triple-system combination can significantly increase the number of observable satellites, optimize the spatial distribution structure of satellites, and is significantly superior to the dual-system and single-system. Finally, the positioning characteristics of single-, dual-, and triple-systems are analyzed. The results of the single station positioning experiment show that the accuracy and convergence speed of the fixed solutions for each system are better than those of the corresponding float solutions. The average root mean squares (RMSs) of the float and the fixed solution in the east and north direction for GPS/Galileo/BDS combined system are the smallest, being 0.92 cm, 0.52 cm and 0.50 cm, 0.46 cm respectively, while the accuracy of the GPS in the up direction is the highest, which is 1.44 cm and 1.27 cm, respectively. Therefore, the combined system can accelerate the convergence speed and greatly enhance the stability of the positioning results.
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Charmley, E., and C. Thomas. "Effect of duration of wilting on the conservation of silage and on gains in body components by steers." Animal Production 48, no. 1 (February 1989): 91–98. http://dx.doi.org/10.1017/s0003356100003822.
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ABSTRACTFour silages were prepared from a sward of perennial ryegrass (Lolium perenne cv. Melle). Two were ensiled directly either without (UWN) or with formic acid at 31 1/t fresh material (UWA). The remaining herbage was left undisturbed in the swath for 43 h (WL) or was spread and harvested after 19 h (WS). The dry matter (DM) concentrations at harvest for the unwilted herbage were 229 (UWN) and 238 g DM per kg (UWA) and wilting increased DM concentration to a similar extent for both treatments (WS, 339 v. WL, 346 g DM per kg).Forty British Friesian steers initially 3·5 months of age and 105 kg live weight were used for the trial. Eight steers were allocated to an initial slaughter group and the remainder were offered the four silages at a restricted level to give 940 kJ digestible energy per kg M0·75. These animals were slaughtered after 112 days to estimate the incremental increases in the components of the body.Loss of DM in the field by respiration increased from 22·2 to 40·6 g/kg DM cut with increased length of wilting. In silo losses were greater with unwilted (UWN, 222, UWA 183 g/kg DM ensiled) than with wilted silage (WS, 133 WL, 122 g/kg DM ensiled). All silages were well preserved. Wilting was more effective than formic acid in reducing total fermentation acids but a lower proportion of these acids was in the form of lactic acid.Live-weight gain was lower for the steers given the control (UWN) silage (398 g/day) than for those given silages UWA (463 g/day), WS (476 g/day) and WL (470 g/day). However, a lower proportion of the gain by steers given UWN was in the form of gut contents so that gains in fat, protein and energy were not significantly affected by treatment. In conclusion, when steers were given similar amounts of digestible energy and unwilted silage was well preserved, neither the use of formic acid nor wilting influenced gains in protein and energy. Further, the duration of wilting, in the absence of any differences in DM content, had no effect on animal performance.
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Frusciante, N., F. Pace, V. F. Cardone, S. Casas, I. Tutusaus, M. Ballardini, E. Bellini, et al. "Euclid: Constraining linearly scale-independent modifications of gravity with the spectroscopic and photometric primary probes." Astronomy & Astrophysics 690 (October 2024): A133. http://dx.doi.org/10.1051/0004-6361/202347526.
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Context. The future Euclid space satellite mission will offer an invaluable opportunity to constrain modifications to Einstein’s general relativity at cosmic scales. In this paper, we focus on modified gravity models characterised, at linear scales, by a scale-independent growth of perturbations while featuring different testable types of derivative screening mechanisms at smaller non-linear scales. Aims. We considered three specific models, namely Jordan-Brans-Dicke, a scalar-tensor theory with a flat potential, the normal branch of Dvali-Gabadadze-Porrati (nDGP) gravity, a braneworld model in which our Universe is a four-dimensional brane embedded in a five-dimensional Minkowski space-time, and k-mouflage gravity, an extension of k-essence scenarios with a universal coupling of the scalar field to matter. In preparation for real data, we provide forecasts from spectroscopic and photometric primary probes by Euclid on the cosmological parameters and the additional parameters of the models, respectively, ωBD, Ωгc and ϵ2,0, which quantify the deviations from general relativity. This analysis will improve our knowledge of the cosmology of these modified gravity models. Methods. The forecast analysis employs the Fisher matrix method applied to weak lensing (WL); photometric galaxy clustering (GCph), spectroscopic galaxy clustering (GCsp) and the cross-correlation (XC) between GCph and WL. For the Euclid survey specifications, we define three scenarios that are characterised by different cuts in the maximum multipole and wave number, to assess the constraining power of non-linear scales. For each model we considered two fiducial values for the corresponding model parameter. Results. In an optimistic setting at 68.3% confidence interval, we find the following percentage relative errors with Euclid alone: for log10 ωBD, with a fiducial value of ωBD = 800, 27.1% using GCsp alone, 3.6% using GCph+WL+XC and 3.2% using GCph+WL+XC+GCsp; for log10 Ωгc, with a fiducial value of Ωгc = 0.25, we find 93.4, 20 and 15% respectively; and finally, for ϵ2,0 = −0.04, we find 3.4%, 0.15%, and 0.14%. From the relative errors for fiducial values closer to their ΛCDM limits, we find that most of the constraining power is lost. Our results highlight the importance of the constraining power from non-linear scales.
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BELEVTSEV, B. I., E. Yu BELIAYEV, and Yu A. KOLESNICHENKO. "1D AND 2D QUANTUM INTERFERENCE EFFECTS IN ELECTRON TRANSPORT IN Au FILM." International Journal of Modern Physics B 27, no. 08 (March 15, 2013): 1350026. http://dx.doi.org/10.1142/s0217979213500264.
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We present transport properties of quench-condensed Au film with nominal thickness ≈3.56 nm and R□ ≈ 5 k Ω for T > 10 K. This film has weak nonmetallic temperature dependence of resistance with logarithmic behavior above 10 K and somewhat stronger dependence at low temperatures. Above 3 K only two-dimensional (2D) quantum interference effects in electron transport have been found; whereas, below 3 K both one-dimensional (1D) and 2D effects of weak localization (WL) and electron–electron interaction (EEI) can be distinguished. This reflects inhomogeneous structure of the film near the thickness-controlled metal-insulator transition (MIT).
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Hartzler, Robert G. "EPTC Reduces Alfalfa (Medicago sativa) Tolerance to Bromoxynil." Weed Technology 5, no. 3 (September 1991): 632–34. http://dx.doi.org/10.1017/s0890037x00027469.
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EPTC applied at the time of ‘Saranac AR’ alfalfa establishment resulted in higher levels of crop injury from the octanoic acid ester of bromoxynil applied postemergence compared to alfalfa in areas not treated with EPTC. EPTC applied at 1.7 or 3.4 kg ai ha-1did not injure alfalfa. At Rock Springs, PA, 0.54 kg ai ha-1bromoxynil caused 28, 43, and 55% foliar injury in areas treated with 0, 1.7, and 3.4 kg ai ha-1EPTC, respectively. A similar interaction was observed at Landisville, PA, although the level of injury due to bromoxynil was less severe. EPTC also predisposed ‘WL 316’ alfalfa to bromoxynil injury in greenhouse experiments.
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Vannoni, Alessandra, Pietro Arena, Bruno Gonfiotti, Marica Eboli, Pierdomenico Lorusso, Amelia Tincani, Nicolò Badodi, et al. "The Design of Water Loop Facility for Supporting the WCLL Breeding Blanket Technology and Safety." Energies 16, no. 23 (November 24, 2023): 7746. http://dx.doi.org/10.3390/en16237746.
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The WCLL Breeding Blanket of DEMO and the Test Blanket Module (TBM) of ITER require accurate R&D activities, i.e., concept validation at a relevant scale and safety demonstrations. In view of this, the strategic objective of the Water Loop (WL) facility, belonging to the W-HYDRA experimental platform planned at C.R. Brasimone of ENEA, is twofold: to conduct R&D activities for the WCLL BB to validate design performances and to increase the technical maturity level for selection and validation phases, as well as to support the ITER WCLL Test Blanket System program. Basically, the Water Loop facility will have the capability to investigate the design features and performances of scaled-down or portions of breeding blanket components, as well as full-scale TBM mock-ups. It is a large-/medium-scale water coolant plant that will provide water coolant at high pressure and temperature. It is composed by single-phase primary (designed at 18.5 MPa and 350 °C) and secondary (designed at 2.5 MPa and 220 °C) systems thermally connected with a two-phase tertiary loop acting as an ultimate heat sink (designed at 6 bar and 80 °C). The primary loop has two main sources of power: an electrical heater up to about 1 MWe, installed in the cold side, downstream of the pump and upstream of the test section, and an electron beam gun acting as a heat flux generator. The WL has unique features and is designed as a multi-purpose facility capable of being coupled with the LIFUS5/Mod4 facility to study PbLi/water reaction at a large scale. This paper presents the status of the Water Loop facility, highlighting objectives, design features, and the analyses performed.
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Sadat Razavi, Mahsa, Abdollah Golmohammadi, Ali Nematollahzadeh, Alireza Ghanbari, Mahdi Davari, Cesare Rovera, Daniele Carullo, and Stefano Farris. "Impact of Bacterial Cellulose Nanocrystals-Gelatin/Cinnamon Essential Oil Emulsion Coatings on the Quality Attributes of ‘Red Delicious’ Apples." Coatings 12, no. 6 (May 28, 2022): 741. http://dx.doi.org/10.3390/coatings12060741.
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This study aimed to assess the effectiveness of bacterial cellulose nanocrystals (BCNCs)-gelatin (GelA)/cinnamon essential oil (CEO) emulsion coatings containing various CEO concentrations (1200, 1800, and 2400 μL/L) in retarding ripening and senescence of ‘Red Delicious’ apples during cold storage (60 days at 4 °C). Coatings decreased the weight loss (WL) (~3.6%), as compared to uncoated fruit (~4.8%). A direct relationship between CEO concentration and respiration rate/ethylene production was also disclosed. Flesh firmness was higher for coated samples, with better results detected especially when the highest amount of CEO was applied (36.48 N for the 2400 μL/L delivered dose vs. 32.60 N for the 1200 μL/L one). These findings were corroborated by additional tests on the surface color, total acidity, soluble solids content, pH, ascorbic acid, and activities of polyphenol oxidase (PPO) and peroxidase (POD). This study demonstrated the capability of BCNCs-GelA/CEO systems to dramatically enhance the storability and quality of apples during refrigerated storage, thus avoiding undesired losses and increasing the economic performance of fresh fruit industries.
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Flessel, John K. "Potato Leafhopper Control, 1991." Insecticide and Acaricide Tests 17, no. 1 (January 1, 1992): 173–74. http://dx.doi.org/10.1093/iat/17.1.173a.
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Abstract A 3-yr-old stand of WL 316' alfalfa at the Ohio Agricultural Research and Development Center, Wooster, was used for this study. Treatments were applied 18 Jul using a tractor mounted hydraulic sprayer calibrated to deliver 20 gal/acre at 32 psi using 8002 Teejet flat-fan nozzles. Plots were 20 by 40 ft, arranged in a randomized complete block design with 4 replicates. Insect samples 1, 3, 8, 14, and 21 DAT were taken with 20 pendulum sweeps with a standard 15-inch sweep net. The alfalfa was 2-4 inches tall at treatment and 12 inches at the completion of the study. The weather was warmer than normal and we were in a severe drought. The first precipitation fell 72 h after application. Precipitation fell on 6 days during the study and totaled 0.67 inches. The drought conditions caused the alfalfa to be stunted (only 12 inches tall versus the expected 18-20 inches at 21 DAT) and pea aphids were virtually nonexistent. Cygon was the standard at 0.25 lb (AI)/acre.
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Hui, Zhenzhen, Xuzhong Zuo, Longqiang Ye, Xuchun Wang, and Xuebin Zhu. "Solution Processable CrN Thin Films: Thickness-Dependent Electrical Transport Properties." Materials 13, no. 2 (January 16, 2020): 417. http://dx.doi.org/10.3390/ma13020417.
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Thickness is a very important parameter with which to control the microstructures, along with physical properties in transition-metal nitride thin films. In work presented here, CrN films with different thicknesses (from 26 to 130 nm) were grown by chemical solution deposition. The films are pure phase and polycrystalline. Thickness dependence of microstructures and electrical transport behavior were studied. With the increase of films thickness, grain size and nitrogen content are increased, while resistivity, zero-field sensitivity and magnetoresistance are decreased. In the temperature range of 5–350 K, all samples exhibited semiconductor-like properties with dρ/dT < 0. For the range above and below the Néel temperature, the resistivity can be fitted by the thermal activation model and the two-dimensional weak localization (2D-WL) model, respectively. The ultra-low magnetoresistance at a low temperature under high magnetic fields with a large zero-field sensitivity was observed in the CrN thin films. The zero-field sensitivity can be effectively tuned to 10−2 K−1 at 5 K with a magnetoresistance of less than 1% at 2 K under 14 T by reasonably controlling the thickness.
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Tannir, Hana, Leila Itani, Dima Kreidieh, Dana El Masri, and Marwan El Ghoch. "Can Intentional Weight Loss Ameliorate Sarcopenia in Individuals with Obesity? A Longitudinal Interventional Study." Clinics and Practice 12, no. 1 (February 17, 2022): 106–12. http://dx.doi.org/10.3390/clinpract12010014.
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Little remains known regarding the impact of weight loss on sarcopenic obesity (SO), and for this reason we aimed to assess the relationship between the two during a weight management program. Body composition was measured at baseline and six-month follow-up using the Tanita BC-418, and step measurements were obtained daily over a period of six months using an Omron HJ-320 pedometer, in 41 adults of both genders with obesity. The participants were then categorized according to the presence or absence of SO. After a significant weight loss, an improvement in the appendicular skeletal mass (ASM) to weight ratio (24.5 ± 3.5 vs. 26.2 ± 3.6, p < 0.01), indicated a decrease in the prevalence of SO by 12.2%. Moreover, these findings were confirmed by logistic regression analysis revealing a significant WL% ≥ 5% combined with an active lifestyle (i.e., ≥8000 steps/day), decreased the risk of SO by 91% (OR = 0.09; 95% CI: 0.02–0.56), after adjusting for age and gender. In conclusion, in a weight management setting, a personalized program for individuals with SO that incorporates new strategies in terms of weight loss and physical activity targets may be adopted to improve the sarcopenia-related index and reduce the prevalence of SO in this population.
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Ramadhani, Tezar Ridho, Siti Masrochah, and Ary Kurniawati. "Efektifitas Variasi Window Width Terhadap Informasi Anatomi CT Scan Sinus Paranasal Citra Jaringan Lunak Pada Kasus Sinusitis." Jurnal Imejing Diagnostik (JImeD) 9, no. 2 (September 24, 2023): 80–87. http://dx.doi.org/10.31983/jimed.v9i2.10330.
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Background: Selection window width (WW) and window level (WL) must be precise to produce an optimal overview of anatomical information on CT scan paranasal sinuses soft tissue window in case of sinusitis. WW affects controlling contrast resolution. A wide window width will appear the less contrast of image. The aim of the study is to know the difference in anatomical information with variation WW and to know the most optimal WW value for CT scan paranasal sinuses soft tissue window in case of sinusitis.Methods: The research design is a quantitative experimental study, using WW variations (90, 120, 200, 350, 400). Anatomical assessment of osteomeatal unit, agger nasi cell, ethmoid roof, onodi cells, sphenoid sinus, optic nerve, middle turbinate, uncinate process, haller cells, And ethmoidal bulla. The friedman test is used to know a significant difference and the highest value of mean rank to know the most optimal WW value.Results: There is difference in information on each anatomical object with a significance value of 0.05 and there is difference in the total information on anatomical object with a significance value of 0.000 0.05. WW 120 is most optimal to display osteomeatal unit, agger nasi cell, ethmoid roof, onodi cells, middle turbinate, uncinate process, and ethmoidal bulla. WW 90 is most optimal to display sinus sphenoidalis, optic nerve, and haller cells.Conclusions: WW 120 is most optimal to display total anatomical information on CT scan paranasal sinuses soft tissue window in case of sinusitis.
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Karmiris-Obratański, Panagiotis, Emmanouil L. Papazoglou, Beata Leszczyńska-Madej, Krzysztof Zagórski, and Angelos P. Markopoulos. "Surface and Subsurface Quality of Titanium Grade 23 Machined by Electro Discharge Machining." Materials 15, no. 1 (December 27, 2021): 164. http://dx.doi.org/10.3390/ma15010164.
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Electrical Discharge Machining (EDM) is a non-traditional cutting technology that is extensively utilized in contemporary industry, particularly for machining difficult-to-cut materials. EDM may be used to create complicated forms and geometries with great dimensional precision. Titanium alloys are widely used in high-end applications owing to their unique intrinsic characteristics. Nonetheless, they have low machinability. The current paper includes an experimental examination of EDM’s Ti-6Al-4V ELI (Extra Low Interstitials through controlled interstitial element levels) process utilizing a graphite electrode. The pulse-on current (IP) and pulse-on time (Ton) were used as control parameters, and machining performance was measured in terms of Material Removal Rate (MRR), Tool Material Removal Rate (TMRR), and Tool Wear Ratio (TWR). The Surface Roughness (SR) was estimated based on the mean roughness (SRa) and maximum peak to valley height (SRz), while, the EDMed surfaces were also examined using optical and SEM microscopy and cross-sections to determine the Average White Layer Thickness (AWLT). Finally, for the indices above, Analysis of Variance (ANOVA) was conducted, whilst semi-empirical correlations for the MRR and TMRR were given using the Response Surface Method (RSM). The results show that the pulse-on time is the most significant parameter of the machining process that may increase the MRR up to 354%. Pulse-on current and pulse-on time are shown to have an impact on the surface integrity of the finished product. Furthermore, statistics, SEM, and EDX images on material removal efficiency and tool wear rate are offered to support the core causes of surface and sub-surface damage. The average microhardness of the White Layer (WL) is 1786 HV.
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Janita Limbong, Rosari, Siti Masrochah, and Nanang Sulaksono. "PROCEDURE OF MULTI SLICE COMPUTED TOMOGRAPHY (MSCT) THORAX EXAMINATION USING POSITIVE CONTRAST MEDIA WITH BREAST CANCER CASE." JRI (Jurnal Radiografer Indonesia) 4, no. 1 (May 10, 2021): 1–9. http://dx.doi.org/10.55451/jri.v4i1.78.
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Background: The protocol for MSCT Thorax examination is axial/coronal/sagittal. The slice thickness parameter has an important role in examining MSCT Thorax in breast cancer cases using contrast media. The thinner the slice thickness, the better the detailed image obtained. The aim of this study is to explain the MSCT Thorax examination procedure in breast cancer cases using positive contrast media, the role of slice thickness in diagnosis and to find out diagnostic information on the MSCT Thorax examination in cancer cases breast.
Methods: This type of research is qualitative with a literature study approach. The data were obtained by identifying the problem then looking for keywords, namely MSCT Thorax, Slice thickness, breast cancer. Literature reviews are carried out through journal search engine searches, such as: Google Scholar, American Journal Rontgenology (AJR), Pubmed, Proquest. The collected journals are reduced based on inclusion criteria so that 3 relevant journals are obtained then analyzed descriptively so that they can answer the objectives to be drawn conclusions.
Results: The results of a literature study show that the MSCT Thorax examination procedure in cases of breast cancer using contrast media is fasting 6 hours before the examination, laboratory checks (urea cratinin within normal limits), releasing all metals in the body, CT scan plane, fixation tools, blankets. , contrast media, injector set.
Conclusion: Contrast media dosage 1-2 ml / kg body weight, flow rate 2-4 ml / s, concentration 300-350 mgl / ml, patient position supine feet first, upper limit of lung Apex and lower limit of diaphragm (depending on needs), axial cut, coronal, sagittal, the parameters used were kV, mAs, slice thickness, matrix, WW, WL. A thin slice thickness will provide more accurate diagnostic information and a clear picture of metastases and small lesions can be seen.
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LEVINZON, FELIX A., and L. K. J. VANDAMME. "COMPARISON OF 1/f NOISE IN JFETs AND MOSFETs WITH SEVERAL FIGURES OF MERIT." Fluctuation and Noise Letters 10, no. 04 (December 2011): 447–65. http://dx.doi.org/10.1142/s0219477511000685.
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Measurement results are presented from 0.1 Hz to 100 kHz of 1/f and thermal noise in different n-JFETs, and n- and p-MOSFETs. The comparison of the 1/f noise is based on Hooge's empirical relation with the 1/f noise parameter α as figure of merit, without suggesting a physical origin. We find that the empirical relation for 1/f noise in MOSFETs and JFETs can be used as a tool to pinpoint the dominant noise source (either ΔN number fluctuations or Δμ mobility fluctuations) and its location, either in the channel or in the parasitic series resistance. Similar relations hold in JFETs and MOSFETs for the 1/f noise corner frequency fc, where thermal and 1/f noise are equal and the ratio fc/fT with fT the unity current gain frequency. The geometry independent parameter α and ratio fc/fT are compared from MOSFETs and JFETs with different channel width (W) and length (L). The results show that very low-noise n-JFETs have a corner frequency fc ≈ 40 Hz, and very low 1/f and thermal noise in agreement with the high W/L ratio and high area WL of the device. Specifically, the equivalent input noise voltage of the investigated JFET IF9030 was about 3.7 nV/√ Hz at 1 Hz, 1.3 nV/√Hz at 10 Hz, and about 0.6 nV/√ Hz (3.6 ×10-19 V2/Hz or Req th noise = 23 Ω) for f ≥ 100 Hz. The 1/f noise parameter α for that JFET is as low as α = 2 × 10-8. This α-value is among the lowest values ever observed. MOSFETs often have α, fc and fc/fT values that are a few decades higher than for JFETs.
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Kaisar, Jeremy, Aaron Chen, Mathew Cheung, Elias Kfoury, Carlos F. Bechara, and Peter H. Lin. "Comparison of propaten heparin-bonded vascular graft with distal anastomotic patch versus autogenous saphenous vein graft in tibial artery bypass." Vascular 26, no. 2 (August 23, 2017): 117–25. http://dx.doi.org/10.1177/1708538117717141.
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Introduction Heparin-bonded expanded polytetrafluoroethylene grafts (Propaten, WL Gore, Flagstaff, AZ, USA) have been shown to have superior patency compared to standard prosthetic grafts in leg bypass. This study analyzed the outcomes of Propaten grafts with distal anastomotic patch versus autogenous saphenous vein grafts in tibial artery bypass. Methods A retrospective analysis of prospective collected data was performed during a recent 15-year period. Sixty-two Propaten bypass grafts with distal anastomotic patch (Propaten group) were compared with 46 saphenous vein graft (vein group). Pertinent clinical variables including graft patency and limb salvage were analyzed. Results Both groups had similar clinical risk factors, bypass indications, and target vessel for tibial artery anastomoses. Decreased trends of operative time (196 ± 34 min vs. 287 ± 65 min, p = 0.07) and length of hospital stay (5.2 ± 2.3 days vs. 7.5 ± 3.6, p = 0.08) were noted in the Propaten group compared to the vein group. Similar primary patency rates were noted at four years between the Propaten and vein groups (85%, 71%, 64%, and 57%, vs. 87%, 78%, 67%, and 61% respectively; p = 0.97). Both groups had comparable secondary patency rates yearly in four years (the Propaten group: 84%, 76%, 74%, and 67%, respectively; the vein group: 88%, 79%, 76%, and 72%, respectively; p = 0.94). The limb salvage rates were equivalent between the Propaten and vein group at four years (84% vs. 92%, p = 0.89). Multivariate analysis showed active tobacco usage and poor run-off score as predictors for graft occlusion. Conclusions Propaten grafts with distal anastomotic patch have similar clinical outcomes compared to the saphenous vein graft in tibial artery bypass. Our data support the use of Propaten graft with distal anastomotic patch as a viable conduit of choice in patients undergoing tibial artery bypass.
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Williams, Ewan R., Chad R. Straight, Hannah K. Wilson, Robert C. Lynall, Chris M. Gregory, and Ellen M. Evans. "Weight Loss and Exercise Effects on Rate of Torque Development and Physical Function in Overweight Older Women." Journal of Aging and Physical Activity, 2022, 1–7. http://dx.doi.org/10.1123/japa.2022-0032.
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Exercise training (EX) and weight loss (WL) improve lower extremity physical function (LEPF) in older overweight women; however, effects on rate of torque development (RTD) are unknown. This study aimed to determine the effects of WL + EX or WL alone on RTD, and relatedly LEPF, in overweight older women. Leg strength was assessed using isokinetic dynamometry, and RTD was calculated (RTD200 = RTD at 200 ms, RTDPeak = peak RTD, T2P = time to 1st peak). LEPF was determined via clinical functional tasks. Women (n = 44, 69.1 ± 3.6 years, 30.6 ± 4.3 kg/m2) completed a 6-month trial in EX + WL or WL groups with similar weight loss (−9.8 ± 4.2%, p > .95). EX + WL had greater improvements in (a) most LEPF tasks (p < .001) and (b) RTD200, compared with WL (36% vs. −16%, p = .031); no other RTD parameters differed. Changes in RTD parameters and LEPF were not related (all p > .05). RTD is responsive to EX but is not associated with LEPF in older women.
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Golling, M., V. Breul, Z. Zielska, and P. Baumann. "The 6:1 short stitch SL-WL-ratio: short term closure results of transverse and midline incisions in elective and emergency operations." Hernia, January 29, 2024. http://dx.doi.org/10.1007/s10029-023-02927-4.
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Abstract Aim To analyze laparotomy closure quality (suture/wound length ratio; SL/WL) and short term complications (surgical site occurrence; SSO) of conventional midline and transverse abdominal incisions in elective and emergency laparotomies with a longterm, absorbent, elastic suture material. Method Prospective, monocentric, non-randomized, controlled cohort study on short stitches with a longterm resorbable, elastic suture (poly-4-hydroxybutyrate, [p-4OHB]) aiming at a 6:1 SL/WL-ratio in midline and transverse, primary and secondary laparotomies for elective and emergency surgeries. Results We included 351 patients (♂: 208; ♀: 143) with midline (n = 194), transverse (n = 103), and a combined midline/transverse L-shaped (n = 54) incisions. There was no quality difference in short stitches between elective (n = 296) and emergency (n = 55) operations. Average SL/WL-ratio was significantly higher for midline than transverse incisions (6.62 ± 2.5 vs 4.3 ± 1.51, p < 0.001). Results in the first 150 patients showed a reduced SL/WL-ratio to the following 200 suture closures (SL/WL-ratio: 5.64 ± 2.5 vs 6.1 ± 2.3; p < 0.001). SL/WL-ratio varied insignificantly among the six surgeons participating while results were steadily improving over time. Clinically, superficial surgical site infections (SSI, CDC-A1/2) were encountered in 8%, while 4,3% were related to intraabdominal complications (CDC-A3). An abdominal wall dehiscence (AWD) occurred in 22/351 patients (6,3%)—twice as common in emergency than elective surgery (12,7 vs 5,1%)—necessitating an abdominal revision in 86,3% of cases. Conclusion We could show that a short stitch 6:1 SL/WL-ratio with a 2–0 single, ultra-long term, absorbent, elastic suture material can be performed in only 43% of cases (85% > 4:1 SL/WL-ratio), significantly better in midline than transverse incisions. Transverse incisions should preferably be closed in two layers to achieve a sufficient SL/WL-ratio equivalent to the median incision. Clinical Trials.gov Identifier NCT01938222.
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Golling, Markus, Zofia Zielska, Katalyn Maurer, and Petra Baumann. "O14 SHORT STITCH TRIAL 6:1 WITH 4-OH-BUTYRATE (MONOMAX) - FINAL RESULTS." British Journal of Surgery 108, Supplement_8 (November 1, 2021). http://dx.doi.org/10.1093/bjs/znab396.013.
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Abstract Aim Surgical technique and material used to close an abdominal wall incision are considered to be important determinants for the risk of developing surgical site occurences (SSOs). Aim of our prospective, non-randomized, monocentric study was a comparative analysis of the perioperative performance (6:1 suture/wound length (SL/WL)-ratio) and SSOs (surgical site infections [SSI] & 2°wound dehiscence/burst abdomen) following midline & transverse incisions. Material and Methods The trial is completed. It included 351 patients between 1/2013-10/2018 in a prospective database. The surgeons aimed at performing a 6:1 SL/WL-ratio in all laparotomies. Patient specific data (risk factors, intra- & postop parameters & SSI/SSO) were entered into the registry database. Satistics involved the Chi2-/ANOVA and Mann-Whitney Test. Results Overall, 82,3% (289/351) were operated electively, 17,7% (62/351) had an emergency laparotomy, 55% (n = 194) had a midline, 29% (n = 103) a transverse and 15% (n = 54) a combined L-shaped laparotomy (liver resection). A learning curve with respect to the bite width was encountered. While SL/WL ratio all laparotomies were similar, bite width varied but improved with experience. SSI was higher in transverse vs. median laparotomies and overall higher in emergency operations. The rate of 2°wound dehiscence (surgical site occurrence [SSO]) stayed at 1/351. Conclusions A learning curve is required to sufficiently perform a short stitch 6:1 suture. Median and transverse laparotomies can be closed safely by a 6:1 SL/WL ratio. SSO could be reduced compared to our historic patient cohort but did not differ within the > and < 6:1 ratio. Emergency laparotomies can also be safely performed with the short stitch technique.
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Schumacher, Kurt R., David N. Rosenthal, Adriana Batazzi, Sunkyung Yu, Garrett Reichle, Maria Bano, Shriprasad R. Deshpande, et al. "Abstract 15192: The Impact of Fontan Circulatory Failure on Heart Transplant Survival: A 20 Center Study." Circulation 148, Suppl_1 (November 7, 2023). http://dx.doi.org/10.1161/circ.148.suppl_1.15192.
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Introduction: Fontan circulatory failure (FCF) is a chronic state in palliated single ventricle heart disease with high morbidity and mortality including heart failure, multisystem end-organ disease, and need for heart transplant (HT). Specific FCF morbidities have not been rigorously defined limiting study of how FCF morbidities impact pre- and post-HT outcomes. Hypothesis: FCF-specific morbidities affect survival from HT waitlisting (WL) through 1-year post-HT. Methods: This 20-center, retrospective cohort study collected demographic, medical/surgical history, WL data, and peri- and post-HT data in Fontan patients WL since 2008. Using Delphi methodology, investigators defined FCF-specific morbidities and collected data. Appropriate univariate 2-group statistics compared surviving individuals with those who 1) died anytime from WL to 1-year post-HT, 2) died on the WL, 3) died within 1-year post-HT. Multivariable logistic regression determined independent risk factors for mortality between WL and 1-year post-HT. Results: Of 409 WL patients, 24 (5.9%) died on the WL. Of the 316 (77%) who underwent HT, 27 (8.5%) did not survive to 1-year. Univariate risk factors for WL death included higher aortopulmonary collateral burden, > 1 hospitalizations in prior year, younger age, sleep apnea, higher NYHA class, non-enrollment in school or work, and single-parent home. Risk factors for 1-year post-HT mortality included HLHS diagnosis, patent fenestration, anatomic Fontan obstruction, clinical cyanosis (pulse oximetry < 90%), polycythemia, portal variceal disease, psychiatric disease requiring treatment, and higher HLA class II PRA. For the 15% of patients not surviving from WL to 1-year post-HT, independent risk factors for mortality included >1 hospitalization in the year prior to WL (aOR 2.0, p=0.05) and clinical cyanosis (aOR 5.0, p=0.002). Notably, some FCF morbidities did not impact post-WL survival including protein-losing enteropathy, plastic bronchitis, and kidney disease. Conclusions: Fontan-palliated patients continue to have high mortality from WL through HT. Among FCF specific morbidities, cyanosis is associated with worsened survival and needs further study. Continued study of FCF phenotype is possible via this dataset.
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Dolla, Caterina, Erika Naso, Alberto Mella, Anna Allesina, Roberta Giraudi, Maria Cristina Torazza, Silvia Bruna Vanzino, et al. "Impact of type 2 diabetes mellitus on kidney transplant rates and clinical outcomes among waitlisted candidates in a single center European experience." Scientific Reports 10, no. 1 (December 2020). http://dx.doi.org/10.1038/s41598-020-78938-3.
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AbstractDespite type 2 diabetes mellitus (T2D) is commonly considered a detrimental factor in dialysis, its clear effect on morbidity and mortality on waitlisted patients for kidney transplant (KT) has never been completely elucidated. We performed a retrospective analysis on 714 patients admitted to wait-list (WL) for their first kidney transplant from 2005 to 2010. Clinical characteristics at registration in WL (age, body mass index -BMI-, duration and modality of dialysis, underlying nephropathy, coronary artery -CAD- and/or peripheral vascular disease), mortality rates, and effective time on WL were investigated and compared according to T2D status (presence/absence). Data about therapy and management of T2D were also considered. At the time of WL registration T2D patients (n = 86) were older than non-T2D (n = 628) (58.7 ± 8.6 years vs 51.3 ± 12.9) with higher BMI (26.2 ± 3.8 kg/m2 vs 23.8 ± 3.6), more frequent history of CAD (33.3% vs 9.8%) and peripheral vascular disease (25.3% vs 5.8%) (p < 0.001 for all analyses). Considering overall population, T2D patients had reduced survival vs non-T2D (p < 0.001). Transplanted patients showed better survival in both T2D and non-T2D groups despite transplant rate are lower in T2D (75.6% vs 85.8%, p < 0.001). T2D was also associated to similar waiting time but longer periods between dialysis start and registration in WL (1.6 years vs 1.2, p = 0.008), comorbidity-related suspension from WL (571 days vs 257, p = 0.002), and increased mortality rate (33.7% vs 13.9% in the overall population, p < 0.001). In T2D patients admitted to WL, an history of vascular disease was significantly associated to low patient survival (p = 0.019). In conclusion, T2D significantly affects survival also on waitlisted patients. Allocation policies in T2D patients may be adjusted according to increased risk of mortality and WL suspension due to comorbidities.
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Golling, Markus, Viktor Breul, Zofia Zielska, Sebastian Felbinger, and Petra Baumann. "6:1 Suture or Wound length ratio with the short stitch technique – a reality check on practicability and short term outcome." Surgery Research Journal 2, no. 2 (December 30, 2022). http://dx.doi.org/10.33425/2768-0428.1018.
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Aim: To analyze laparotomy closure of conventional midline and transverse abdominal incisions in elective and emergency laparotomies with a longterm, absorbent, elastic suture material. Method: Prospective, single centre, non randomised, controlled cohort study on short stitches with a longterm resorbable, elastic suture (material: poly-4-hydroxybutyrate) aiming at a 6:1 suture to wound (SL/WL) length ratio in midline and transverse, primary & secondary laparotomies for elective & emergency surgery. Results: We included 351 patients (♂: 208; ♀: 143), midline (n=194), transverse (n=103) and a combined midline/transverse L-shaped (n=54) incisions. There was no stitch performance quality difference between elective (n=296) and emergency (n=55) operations, while results in the first 150 patients showed a significantly reduced SL/WL-ratio to the following 200 suture closures (SL/WLratio: 5.64±2.5 vs 6.1±2.3, p<0.001). Average SL/WL-ratio in general was better for midline than transverse incision sutures (6.62±2.5 vs 4.3±1.51, p<0.001). SL/WL-ratio varied among the 6 surgeons participating, although results steadily improved and eventually approximated each other. Conclusions: We could show that a 6:1 SL/WL-ratio with a 2-0 single, ultra-long term, absorbent, elastic suture material can be significantly performed better in midline than transverse incisions. Transverse incisions should preferably be closed in 2 layers in order to achieve a sufficient SL/WL-ratio equivalent to the median incision. While on an individual level, results varied between surgeons, quality will improve and eventually approximate.
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Okada, Masato, Nobuaki Tanaka, Katsuomi Iwakura, Masahiro Seo, Takaharu Hayashi, Masamichi Yano, Akito Nakagawa, et al. "Abstract 13242: Annual Body Weight Change and Subsequent Prognosis in Heart Failure With Preserved Ejection Fraction: Insights From the PURSUIT-HFpEF Registry." Circulation 148, Suppl_1 (November 7, 2023). http://dx.doi.org/10.1161/circ.148.suppl_1.13242.
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Introduction: Maintaining optimal body weight is important in heart failure management. Weight gain (WG) may signal excessive caloric intake and fluid retention, whereas weight loss (WL) would imply cachexia. Both conditions could affect the prognosis of heart failure with reduced ejection fraction. However, the significance of WG and WL in patients with heart failure and preserved ejection fraction (HFpEF) has not been well established. Methods: An analysis was performed from a prospective multicenter observational registry for HFpEF (PURSUIT-HFpEF Registry) conducted in the Osaka region of Japan. Of 1231 patients who enrolled in the registry, we enrolled 662 patients (age, 82±9 years; females, 54.1%; body mass index, 22.3±4.3kg/m 2 ; atrial fibrillation, 38.3%) whose weight at discharge and one year later were both available. WG and WL were defined as a gain or loss of ≥5% weight between baseline and 1 year, respectively. Other patients who did not demonstrate a significant change in weight were categorized as having a stable weight (SW). All-cause mortality was the primary endpoint. Results: During 1-year, the median body weight slightly increased from 52.1 (interquartile range [IQR]: 45.1-61.9) to 53.0 kg (IQR 45.0-63.0) kg (p <0.001), with a median change of 0.6 kg (IQR: -1.8-2.8). A total of 182 (27%), 125 (19%), and 355 (54%) patients experienced WG, WL, and SW, respectively. During a follow-up of 603 days (IQR: 329-982), 149 patients died. The mortality rate was highest in patients experiencing WL, followed by those experiencing WG and SW (30.2% vs. 21.5% vs. 18.0%, respectively; log-rank p = 0.006). After adjusting for potential confounders, Cox regression analysis revealed that WL, not WG, was independently associated with higher mortality (hazard ratio 2.44 [95% CI 1.51-3.95], p <0.001). Conclusions: Significant number of patients with HFpEF experienced WG and WL within a year. Patients who experienced WL had a higher risk of mortality compared to those who experienced WG and SW. These results highlight the importance of monitoring body weight changes in the management of HFpEF.
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Zhang, Xin, Mingyu Chen, Tianren Zhong, Angelo De Santis, and Peng Han. "Far‐Field Groundwater Response to the Lamb Waves From the 2022 Hunga‐Tonga Volcano Eruption." Geophysical Research Letters 51, no. 11 (June 6, 2024). http://dx.doi.org/10.1029/2023gl107442.
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AbstractOn 15 January 2022, the largest eruption of the Hunga‐Tonga volcano in recorded history produced a plume registered by multi‐parametric instruments around the world. However, the far‐field hydrogeological responses to Lamb waves from this eruption remain underexplored. We studied the responses of groundwater to the volcanic eruption in the far‐field over 8,700 km, including 274 wells. Results show that the Lamb waves with a speed of 316 m/s affects the groundwater system, leading to similar fluctuations in well water level (WL) and opposite phase fluctuation in borehole strain. Different wells exhibit diverse responses in WL amplitudes, possibly for heterogeneities in local aquifer systems. Gain values of 5 wells that simultaneously measure atmospheric pressure, borehole air pressure, borehole strain and WL are consistent with results obtained through cross‐power spectrum estimation. This work demonstrates a novel response in far‐field groundwater systems induced by Lamb waves and expects application for aquifer parameter estimation.
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Johnson, Kelly E., Michelle K. Alencar, Brian Miller, Elizabeth Gutierrez, and Patricia Dionicio. "Exploring Sex Differences in the Effectiveness of Telehealth-Based Health Coaching in Weight Management in an Employee Population." American Journal of Health Promotion, July 27, 2020, 089011712094336. http://dx.doi.org/10.1177/0890117120943363.
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Purpose: To explore a telehealth-based lifestyle therapeutics (THBC) program on weight loss (WL) and program satisfaction in an employer population. Design: This study was a collaboration between inHealth Lifestyle Therapeutics and a large national employer group including 685 participants (296 women [64% obese] and 389 men [62% obese]). Measures: Percent WL and subjective rating (Perceived Program Value measured by a questionnaire) were assessed. Intervention: Average number of visits was 3.1 ± 0.4; each visit ranged between 20 and 45 minutes. Analysis: This study utilized a 2 × 2 block design using analysis of variance techniques based on sex (male and female) and initial body mass index (BMI) category (overweight and obese) tested at P ≤ .05. Results: There was no statistical difference in %WL between by sex ( F 1,681 = 0.398, P = .528) nor an interaction between sex and BMI ( F 1,681 = 0.809, P = .369). There was a statistically significant difference in %WL from pre to post program across initial BMI category ( F 1,681 = 13.707, P ≤ .001) with obese participants losing an average of 1.1% (0.5%-1.6%) more than overweight participants (overweight 2.5% [2.1%-3.0%] vs obese 3.6% [3.2%-3.9%]). Obese participants were 1.15 (1.07-1.25) times more likely to lose weight compared to overweight participants. Analysis of variance power analysis indicated sufficient power on minimum factor combination n = 106 ( Effect Size = 0.282). Conclusion: Results support the efficacy THBC in supporting WL with no reported differences between men and women, while having a high perceived value for employee participants.
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Kaur, Gurveen, Anchu Rachel Thomas, Renu Sarah Samson, Eby Varghese, Ratna Rachel Ponraj, Sumanth Kumbargere Nagraj, Deepti Shrivastava, et al. "Efficacy of electronic apex locators in comparison with intraoral radiographs in working length determination- a systematic review and meta-analysis." BMC Oral Health 24, no. 1 (May 4, 2024). http://dx.doi.org/10.1186/s12903-024-04259-w.
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Abstract Background Successful endodontic treatment needs accurate determination of working length (WL). Electronic apex locators (EALs) were presented as an alternative to radiographic methods; and since then, they have evolved and gained popularity in the determination of WL. However, there is insufficient evidence on the post-operative pain, adequacy, and accuracy of EALs in determining WL. Objective The systematic review and meta-analysis aims to gather evidence regarding the effectiveness of EALs for WL determination when compared to different imaging techniques along with postoperative pain associated with WL determination, the number of radiographs taken during the procedure, the time taken, and the adverse effects. Methods For the review, clinical studies with cross-over and parallel-arm randomized controlled trials (RCTs) were searched in seven electronic databases, followed by cross-referencing of the selected studies and related research synthesis. Risk of bias (RoB) assessment was carried out with Cochrane's RoB tool and a random-effects model was used. The meta-analysis was performed with the RevMan software 5.4.1. Results Eleven eligible RCTs were incorporated into the review and eight RCTs into the meta-analysis, of which five had high RoB and the remaining six had unclear RoB. Following meta-analysis, no significant difference in postoperative pain was found among the EAL and radiograph groups (SMD 0.00, CI .29 to .28, 354 participants; P value = 0.98). Radiograph group showed better WL accuracy (SMD 0.55, CI .11 to .99, 254 participants; P value = 0.02), while the EAL group had 10% better WL adequacy (RR 1.10, CI 1.03–1.18, 573 participants; P value = 0.006). Conclusion We found very low-certainty evidence to support the efficacy of different types of EAL compared to radiography for the outcomes tested. We were unable to reach any conclusions about the superiority of any type of EAL. Well-planned RCTs need to be conducted by standardizing the outcomes and outcome measurement methods.
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Dix, Alissa, Kathryn Porter Starr, Dipa Patel, Richard Sloane, Connie Bales, and Melissa Orenduff. "Balanced, Higher Protein at Meals in the Context of Obesity Intervention: A Diet Feasibility Study (P21-003-19)." Current Developments in Nutrition 3, Supplement_1 (June 1, 2019). http://dx.doi.org/10.1093/cdn/nzz041.p21-003-19.
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Abstract Objectives Obesity is a major health concern in mid and later life; ≥40% of those ≥60 years are obese. However, the optimal approach for obesity reduction during the latter half of life has not been identified. Consuming balanced, liberal amounts of high quality protein at each meal is recommended for older adults and could help preserve lean mass and physical function. This study examined the feasibility and efficacy of this approach in the context of a weight reduction intervention for obese middle-aged and older adults. Methods This analysis combines findings on calorie and protein intakes of obese participants (mean BMI = 37.4 kg/m2; 88.7% female) aged ≥ 45 yrs (mean = 64.8 yrs) from two RCTs with similar protocols. Participants were randomized to hypo-caloric diets with either RDA level protein (0.8 g/kg bw; C-WL) or higher protein (1.2 g/kg bw; HP-WL) for 6 months. The HP-WL group was counseled to consume 30 g high quality protein/meal and provided lean beef or pork for 2 of 3 meals daily. Both groups had weekly group counseling and weigh-ins. Diet records (3-day) collected at 0, 3 and 6 months were analyzed (Food Processor; ESHA Research) for daily intakes of kcals and macronutrients. Results Both C-WL (n = 30) and HP-WL (n = 59) reduced their kcal intake and successfully reduced their body mass. At 6 months, weight loss was 5.8% and 7.0% for C-WL and HP-WL, respectively. Diet record analysis confirmed HP-WL participants achieved intakes of 30 g protein/meal. At 3 and 6 months respectively, mean ± SD protein intakes were 30.1 ± 9.9 g and 29.7 ± 12 g for breakfast; 37.5 ± 8.2 g and 35.6 ± 9.3 g for lunch; and 40.7 ± 13.7 g and 39.2 ± 8.1 g for dinner; daily protein intake was 1.2 ± 0.3 g/kg bw. In contrast, the C-WL protein intakes remained unchanged (0.8 g/kg bw). Conclusions These findings confirm the feasibility of a balanced, higher protein weight loss diet for obese middle-aged and older adults. HP-WL participants achieved notable weight reduction while also meeting meal protein goals. This practical dietary approach may offer superior long-term outcomes for physical function in this high-risk population; thus, further study of these potential benefits is warranted. Funding Sources Beef Checkoff and Pork Checkoff, North Carolina Pork Council, Smithfield Foods, NIH (T32 AG000029), and US Department of Veterans Affairs Rehabilitation Research and Development Service Program (CDA-2/IK2 RX002348).
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Xu, Li-Bin, Ting-Ting Mei, Yi-Qi Cai, Wen-Jing Chen, Si-Xin Zheng, Liang Wang, Xiao-Dong Chen, and Yun-Shi Huang. "Correlation Between Components of Malnutrition Diagnosed by Global Leadership Initiative on Malnutrition Criteria and the Clinical Outcomes in Gastric Cancer Patients: A Propensity Score Matching Analysis." Frontiers in Oncology 12 (March 3, 2022). http://dx.doi.org/10.3389/fonc.2022.851091.
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ObjectiveMalnutrition is recognized as a risk factor for poor outcome in patients with gastric cancer (GC). In 2018, the Global Leadership Initiative on Malnutrition (GLIM) published standardized criteria for the diagnosis of malnutrition. Our aim was to investigate whether any of the components of the GLIM diagnostic criteria were related to worse clinical outcomes in patients with GC.MethodsThis study analyzed patients with GC who underwent radical gastrectomy in our hospital between 2014 and 2019. A preoperative nutritional assessment was performed for each patient. Matching was based on the presence of three GLIM components: high weight loss (WL), low body mass index (BMI), and low skeletal muscle index (SMI).ResultsThe analysis included 1,188 patients, including 241 (20.3%) with high WL, 156 (13.1%) with low BMI, and 355 (29.9%) with low SMI. Before matching, patients who met the GLIM component criteria were mostly associated with older age, low nutritional reserves, and late tumor progression. After matching, the clinical characteristics of the three cohorts were balanced. In the matched queue, the survival prognosis of the high WL group was worse than that of the non-WL group, and the postoperative complication rate was higher in the low SMI group than in the normal SMI group (P <0.05). In addition, the clinical outcomes in the low and normal BMI groups were similar (P >0.05).ConclusionOf the GLIM criteria, high WL and low SMI may be associated with poor clinical outcomes in patients with GC, while a low BMI may not be associated with outcome.
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"Methods for creating transgenic animals (R Bremel et al, Wl, CA, USA)." Biofutur 1998, no. 184 (December 1998): 100. http://dx.doi.org/10.1016/s0294-3506(99)80035-0.
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Kawai, Taketo, Hideyasu Matsuyama, Keita Kobayashi, Atsushi Ikeda, Makito Miyake, Koshiro Nishimoto, Yuto Matsushita, et al. "Photodynamic diagnosis‐assisted transurethral resection of bladder tumor for high‐risk non‐muscle invasive bladder cancer improves intravesical recurrence‐free survival (BRIGHT study)." International Journal of Urology, May 2, 2024. http://dx.doi.org/10.1111/iju.15483.
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ObjectivesIn a primary analysis of data from the BRIGHT study (UMIN000035712), photodynamic diagnosis‐assisted transurethral resection of bladder tumor (PDD‐TURBT) using oral 5‐aminolevulinic acid hydrochloride reduced residual tumors in high‐risk non‐muscle invasive bladder cancer (NMIBC). We aimed to evaluate the effectiveness of PDD‐TURBT for intravesical recurrence after a second transurethral resection for high‐risk NMIBC.MethodsHigh‐risk NMIBC patients initially treated with PDD‐TURBT (PDD group) were prospectively registered between 2018 and 2020. High‐risk patients with NMIBC who were initially treated with white‐light TURBT (WL group) were retrospectively registered. Intravesical recurrence‐free survival after the second transurethral resection was compared between the PDD and WL groups using propensity score matching analysis.ResultsIn total, 177 patients were enrolled in the PDD group, and 306 patients were registered in the WL group. After propensity score matching (146 cases in each group), intravesical recurrence within 1 year was significantly less frequent in the PDD group than in the WL group (p = 0.004; hazard ratio [HR] 0.44, 95% confidence interval [CI]: 0.25–0.77). In subgroup analysis, PDD‐TURBT showed a particularly high efficacy in reducing intravesical recurrence within 1 year, especially in cases of tumors measuring less than 3 cm (p = 0.003; HR 0.31, 95% CI: 0.14–0.67), absence of residual tumor at second transurethral resection (p = 0.020; HR 0.37, 95% CI: 0.16–0.86), and no postoperative intravesical Bacillus Calmette‐Guérin therapy (p < 0.001; HR 0.27, 95% CI: 0.13–0.58).ConclusionsPDD‐TURBT may reduce short‐term intravesical recurrence in patients with high‐risk NMIBC.
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Zhang, Zhenghua, Yang Tian, Wenjun Gao, Yubin Hu, Liangping Luo, Lichang Lei, Shasha Shen, and Dan Han. "Detection of PD-L1 expression levels in malignant pleural mesothelioma with a targeted MRI nanoprobe in vivo." Frontiers in Chemistry 12 (December 2, 2024). https://doi.org/10.3389/fchem.2024.1508912.
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ObjectivesImmune checkpoint inhibitors (ICIs) have demonstrated potential in inhibiting the growth of malignant pleural mesothelioma (MPM), and their efficacy is associated with the expression of programmed death-ligand 1(PD-L1). This study evaluated a PD-L1-targeted nanoprobe for detecting PD-L1 expression in a nude mouse model of malignant pleural mesothelioma (MPM).MethodsA PD-L1-binding peptide (WL-12) was conjugated with superparamagnetic iron oxide nanoparticles (SPIONs) to create the nanoprobe WL-12@Fe₃O₄. The nanoprobe’s stability, biotoxicity, targeting ability, and in vivo magnetic resonance (MR) imaging effects were assessed and compared to non-targeted Fe₃O₄ nanoparticles. ΔT2 values and PD-L1 expression were measured in H226 and MSTO-211H tumor tissues over 4 weeks to analyze correlations.ResultsThe WL-12@Fe₃O₄ nanoprobe demonstrated uniform distribution and a spherical shape, with a larger size (43.82 nm) and lower surface potential (−9.34 ± 0.54 mV) compared to Fe₃O₄ (32.67 nm, −20.20 ± 0.88 mV, P < 0.05). The XPS and FT-IR analysis results indicate the successful coupling of WL-12 with Fe3O4. It was well dispersed in serum and saline and showed no cytotoxicity or organ damage in vivo. The probe selectively accumulated in PD-L1-expressing MPM cells, especially MSTO-211H, and exhibited significantly higher uptake in high PD-L1-expressing H460 cells (930.22 ± 11.75 ng/mL) compared to low PD-L1-expressing A549 cells (254.89 ± 17.33 ng/mL, P < 0.05). Tumor iron levels in the WL-12@Fe₃O₄ group were significantly elevated (141.02 ± 17.33 μg/g) compared to controls (36.43 ± 3.56 μg/g, P < 0.05), with no significant differences in other organs (P > 0.05). The T2 values of H226 and MSTO-211H tumors decreased after probe injection, with ΔT2 values significantly higher in the targeted group than the nontargeted group (P < 0.05). ΔT2 values increased over 4 weeks, correlating strongly with PD-L1 expression (P < 0.05).ConclusionThe PD-L1-targeted nanoprobe with MRI is a promising tool for noninvasive, real-time assessment of PD-L1 expression in MPM.
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Farrera. Ayestaran, A., V. Montalvo, J. Masso, A. Garcia-Faura, B. Marques, and M. Lopez-Teijon. "P–188 Ambient light intensity and wavelength in the IVF laboratory does not affect life birth rates." Human Reproduction 36, Supplement_1 (July 1, 2021). http://dx.doi.org/10.1093/humrep/deab130.187.
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Abstract Study question Do different wavelengths and intensities in ambient lighting affect clinical outcomes? Summary answer Variations on ambient lighting intensity and wavelength do not affect life birth rates. What is known already Light is one of the factors to consider when designing an IVF laboratory. Most IVF clinics work under reduced illumination, trying to mimic uterine conditions as much as possible. Nevertheless, it has been described that 95% of the light that affects an embryo comes from the microscope, not ambient lighting. It is well accepted that exposure to extreme lighting conditions affects embryos through photo-oxidation and the creation of reactive oxygen species. Still, there is no study that documents the effect of different wavelengths on human embryos. Study design, size, duration Prospective study performed between january 2019 and february 2020. Every 60 days we changed ambient illumination conditions using the LED lighting installed throughout the IVF laboratory. Six different groups were created: Cyan (470nm), Green (550nm), Yellow (600nm), Orange (625nm), intense white (WH), and low intensity white (WL) as control group. Participants/materials, setting, methods A total of 572 egg donation cicles with 355 fresh single embryo transfers were included in the study. In all cycles ICSI and Time-lapse culture was performed (Embryoscope, Vitrolife). PGT and testicular biopsy/aspiration treatments were excluded. Eggs and embryos were exposed to ambient illumination during pick-up, denudation, ICSI, and embryo transfer procedures. Main results and the role of chance Light exposure during embryo/gamete manipulation is inevitable. Hence, we analyzed parameters linked to the success of an IVF cycle to assess the effect of different lighting conditions concluding that neither light color nor intensity affect IVF success rates. No differences were found between groups regarding maternal age, age of the recipient, diagnostic, or number of eggs received (p > 0.05). Fertilization rates were similar between groups (C = 77.04%; G = 73.72%; Y = 75.64%; O = 78.1%; WL = 76.4%; WH = 75.2%; p = 0.216) as well as good quality blastocyst rates (C = 57.35%; G = 57.37%; Y = 62.30%; O = 59.75%; WL = 63.28%; WH = 60.55%; p = 0.234). Regarding clinical outcomes both implantation and miscarriage rates were found to be equal between groups (C = 61.67%; G = 52.89%; Y = 55.10%; O = 66.18%; WL = 66.00%; WH = 53.55%; p = 0.194, and C = 24.32%; G = 19.15%; Y = 11.11%; O = 24.44%; WL = 15.15%; WH = 8.11%; p = 0.301). The main outcome for this study was live birth rates and no differences were found (C = 51.85%; G = 50.00%; Y = 52.17%; O = 53.97%; WL = 57.14%; WH = 50.75%; p = 0.168). Limitations, reasons for caution We must take into account that embryos were cultured inside a time-lapse incubator, diminishing the effect of ambient light. Wider implications of the findings: This study demonstrates that, with advances in culture technology, neither light intensity nor light wavelength affecting gametes/embryos during manipulation influence clinical outcomes. Trial registration number Not applicable
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Bella, Angelo, Nathan Carlson, and Ivan S. Gotchev. "On spaces with a $$\pi $$-base with elements with compact closure." Revista de la Real Academia de Ciencias Exactas, Físicas y Naturales. Serie A. Matemáticas 118, no. 1 (November 11, 2023). http://dx.doi.org/10.1007/s13398-023-01526-3.
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AbstractIn this paper we show that if X is a $$T_1$$ T 1 -space with a $$\pi $$ π -base whose elements have compact closure, then $$d(X)\le c(X)\cdot 2^{\psi (X)}$$ d ( X ) ≤ c ( X ) · 2 ψ ( X ) and therefore, for such spaces we have $$d(X)^{\psi (X)} = c(X)^{\psi (X)}$$ d ( X ) ψ ( X ) = c ( X ) ψ ( X ) . This result allows us to restate several known upper bounds of the cardinality of a Hausdorff space X by replacing in them d(X) with c(X). In addition, we show that for such spaces X Šapirovskiĭ’s inequality $$d(X)\le \pi \chi (X)^{c(X)}$$ d ( X ) ≤ π χ ( X ) c ( X ) , which is known to be true for regular Hausdorff spaces, is also valid. In the case when the space X is in addition sequential or radial, we show that $$|X|\le 2^{c(X)}$$ | X | ≤ 2 c ( X ) . This result extends two theorems of Arhangel$$'$$ ′ skiĭ to the class of Hausdorff spaces with a $$\pi $$ π -base whose elements have compact closures. We also show that spaces with a $$\pi $$ π -base with elements with compact closures are $$\alpha $$ α -favorable in the Banach–Mazur game, which implies such spaces are Baire. It was shown in Bella et al. (Quaest Math 46(4):745–760, 2023) that if a Hausdorff space X has a $$\pi $$ π -base consisting of elements with compact closure, then $$|X|\le 2^{wL(X)t(X)\psi _c(X)}$$ | X | ≤ 2 w L ( X ) t ( X ) ψ c ( X ) . We give a variation of this result by showing $$|X|\le \pi \chi (X)^{wL(X)\textrm{ot}(X)\psi _c(X)}$$ | X | ≤ π χ ( X ) w L ( X ) ot ( X ) ψ c ( X ) for such a space X. Note that since $$wL(X)\textrm{ot}(X)\le c(X)$$ w L ( X ) ot ( X ) ≤ c ( X ) , this result is at least as good as that given by Sun (Proc Am Math Soc 104:313–316, 1988). We also give a possible improvement of the bound in Bella et al. (2023) by showing that $$|X|\le 2^{wL(X)wt(X)\psi _c(X)}$$ | X | ≤ 2 w L ( X ) w t ( X ) ψ c ( X ) for a Hausdorff space X with a $$\pi $$ π -base consisting of elements with compact closure. This uses the weak tightness wt(X) defined in Carlson (Topol Appl 249:103–111, 2018), which has the property $$\textrm{ot}(X)\le wt(X)\le t(X)$$ ot ( X ) ≤ w t ( X ) ≤ t ( X ) . We also show that if X is a Hausdorff homogeneous space with a $$\pi $$ π -base consisting of elements with compact closure (such spaces are locally compact), then $$|X|\le wL(X)^{wt(X)\pi \chi (X)}$$ | X | ≤ w L ( X ) w t ( X ) π χ ( X ) . This generalizes the result in Bella and Carlson (Monatsh Math 192(1):39–48, 2020) that if X is a homogeneous compactum, then $$|X|\le 2^{wt(X)\pi \chi (X)}$$ | X | ≤ 2 w t ( X ) π χ ( X ) .
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Fujihana, T., O. Nishimura, K. Yabe, H. Hayashi, and M. Iwaki. "Effect of Titanium Implantation on the Mechanical Properties of Silicon Nitride." MRS Proceedings 354 (1994). http://dx.doi.org/10.1557/proc-354-249.
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AbstractA study has been made of the chemical composition and mechanical properties of Ti+-implanted Si3N4 surface layers. Implantation of 48Ti+ was performed with doses ranging from 10 to 1017 ions cm”2 at an energy of 150 keV, and at nearly room temperature. XPS was used to analyze the depth dependence of atomic fraction and chemical bonding states of Ti+-implanted layers. The near-surface hardness was measured by a Vickers hardness tester. The friction and wear properties were measured under unlubricated conditions at room temperature using a pin on disk-plane and a block on wheel-periphery configurations, in which the pin and wheel used were AISI1045 and ASTM Wl-9, respectively. Implanted Ti-atoms formed a gaussian distribution predicted by the range theory. At the average projected range, most of Ti-atoms existed as a metallic state and TiN bonding was also formed. Oxygen and carbon were found near the surface layers. In addition to the surface peak, O-atoms accumulated in front of the average projected range of Ti. Such O-atoms formed bonds of Si-oxides and Ti-oxides. Carbon existed as a graphitic state. With increasing a Ti dose, the near-surface hardness decreased, and the wear rate increased at the running-in stage having the high friction coefficient. The steady wear attributed to the stable friction coefficient appeared after the running-in stage, although such a stable stage was not observed for unimplanted Si3N4. The mechanism for the change in mechanical properties of Si3N4 induced by Ti+-implantation will be discussed in relation to XPS characteristics.
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"Cost analysis of glaucoma medications: a 3-year review. Vold SD,**Dr. Steven D. Vold, Scott and White Clinic, 2401 South 31st Street, Temple, TX 76508; e-mail: sdvold@swmail.sw.org Riggs WL, Jackimiec J. J Glaucoma 2002;11:354–358." American Journal of Ophthalmology 135, no. 4 (April 2003): 573. http://dx.doi.org/10.1016/s0002-9394(03)00036-9.
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