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Ciocoi-Pop, Ana-Blanca. "“Unicul Lucru Capabil Să Surprindă Un Crâmpei De VeȘnicie, Este Arta” Forestiera Feltrinelli, De Joachim Wittstock, Traducere De Maria Sass." Lucian Blaga Yearbook 21, no. 1-2 (December 1, 2020): 291–98. http://dx.doi.org/10.2478/clb-2020-0019.
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Abstract Joachim Wittstock’s novella Forestiera Feltrinelli, translated into Romanian by Maria Sass, appeared under the aegis of the Honterus publishing house in Sibiu, in 2019. Combining present-day economic realities, with a parallelism of temporal planes, and the antonimy between the mythical past and the disillusioning present, Wittstock manages to interweave in his most recent volume social and historical analyses, love stories and subtle eroticism, existentialist concerns and political dimensions. The volume can be regarded as an important contribution to a better relationing of the Romanian readership with German literature in Romania, and to a better understanding of the complex thematic and narrative mechanisms in Joachim Wittstock’s works. A fascinating page of the history of Sibiu, of the Romanian Saxons, and of the author’s biography, the volume is a succesful and innovative attempt in the landscape of contemporary Romanian and European literature, and its Romanian translation a welcome and necessary initiative in view of a multicultural understanding of the literatures of ethnic minorities in Romania.
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Cortie, M. B. "“Nanoporous gold”, A. Wittstock et al. (eds.)." Gold Bulletin 45, no. 4 (October 31, 2012): 233–34. http://dx.doi.org/10.1007/s13404-012-0072-7.
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Neufang, Matthias. "Solution to a conjecture by Hofmeier–Wittstock." Journal of Functional Analysis 217, no. 1 (December 2004): 171–80. http://dx.doi.org/10.1016/j.jfa.2004.02.013.
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Greavu, Alexandra. "Rezension: Kronstädter Beiträge zur germanistischen Forschung, Band 20: Gesehenes, Gehörtes, Erdachtes. Kulturelle, literarische und sprachliche Paradigmen und Strategien der (rumänien)deutschen Postmoderne. Aldus Verlag, Kronstadt:2020." Germanistische Beiträge 47, no. 1 (December 1, 2021): 302–17. http://dx.doi.org/10.2478/gb-2021-0019.
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Abstract The present paper reviews the articles published in the 20th volume of the Kronstädter Beiträge zur germanistischen Forschung, which focus on a variety of postmodern elements found within German culture, language, and literature. A special emphasis is set on the person and works of the German author living in Romania Joachim Wittstock, whom the given volume has been dedicated to, on the occasion of his 80th birthday.
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Helemskii, A. Ya. "Nonmatricial version of the Arveson-Wittstock extension principle, and its generalization." Functional Analysis and Its Applications 42, no. 3 (July 2008): 213–19. http://dx.doi.org/10.1007/s10688-008-0030-6.
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Eimers, Enno. "Sylvia Asmus/Uwe Wittstock: Marcel Reich-Ranicki. Ein Leben, viele Rollen." Das Historisch-Politische Buch (HPB) 69, no. 1-2 (January 1, 2021): 61–62. http://dx.doi.org/10.3790/hpb.69.1-2.61.
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Толстова, Елена Владимировна, and Владимир Александрович Иванов. "DEVELOPMENT OF INTERNATIONAL NATURE-BASED EDUCATION FROM LUTHER THROUGH WITTSTOCK TO VOLKOV." Bulletin of the Chuvash State Pedagogical University named after I Y Yakovlev, no. 2(115) (July 26, 2022): 226–35. http://dx.doi.org/10.37972/chgpu.2022.115.2.030.
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В статье рассматриваются чувашские и немецкие пословицы о природосообразном воспитании, проводится их сравнение, выявляется общее и специфичное, обнаруживается потенциал для совершенствования образовательного процесса через его этнопедагогизацию. Активное обращение к опыту народного воспитания актуально сегодня ввиду сложной политической и экологической ситуации в мире. Материалом для исследования послужили малоизвестный труд немецкого филолога А. Виттштока «Воспитание пословицей», высказывания реформатора М. Лютера о воспитании детей, труды академика Г. Н. Волкова, а также деятельность этих ученых в сфере образования. Основное внимание в статье уделено немецкоязычному труду «Воспитание пословицей», который можно по праву назвать энциклопедией немецкой народной педагогики, где автором дано представление о принципах воспитания молодежи, идеях прогрессивных педагогов того времени, приведены примеры из жизни выдающихся людей. Несмотря на разницу в несколько веков между источниками паремий, сравнительно-сопоставительный анализ чувашских и немецких пословиц позволяет выявить общие черты в педагогических представлениях народов о последовательности в воспитании, ценности детской игры в обучении детей, роли матери, семьи, специфике женского образования, уважении к труду, бережном отношении к единой для всех народов природе. На основании проведенного исследования делается вывод о способности паремий внести вклад в приобщение современного поколения к истории, коллективной этнической памяти, воспитание достойных граждан своей страны, ценящих традиции и ответственно относящихся к окружающей среде. The article deals with the Chuvash and German proverbs about nature-based education, compares them, reveals some common and specific features, presents their potential for improving the educational process through its ethnopedagogization. An active use of the experience of folk education is relevant today due to the difficult political and environmental situation in the world. The little-known work of the German philologist A. Wittstock “Education through a Proverb”, the statements of the reformer M. Luther on the upbringing of children, the works of academician G. N. Volkov, as well as the activities of these scientists in the field of education provided the material for the current work. The main attention in the article is paid to the book “Education through a Proverb” in German which can be called the encyclopedia of German folk pedagogy, where the author gives an idea of the principles of educating young people, the ideas of progressive teachers of that time, and also provides examples from the lives of prominent people. Despite the difference of several centuries between the sources of paremias considered, a comparative analysis of the Chuvash and German proverbs reveals some common features in the pedagogical ideas of peoples about consistency in education, value of children’s play in teaching children, the role of mother, family, specifics of women’s education, respect for work, care for nature. On the basis of the study, a conclusion is made about the ability of proverbs to contribute to familiarizing the modern generation with history, collective ethnic memory, educating worthy citizens of their country who appreciate traditions and treat environment responsibly.
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Showalter, Dennis, and William P. Guthrie. "The Later Thirty Years War. From the Battle of Wittstock to the Treaty of Westphalia." German Studies Review 27, no. 2 (May 2004): 370. http://dx.doi.org/10.2307/1433094.
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Ivonin, Yuri, and William P. Guthrie. "The Later Thirty Years' War: From the Battle of Wittstock to the Treaty of Westphalia." Sixteenth Century Journal 36, no. 4 (December 1, 2005): 1168. http://dx.doi.org/10.2307/20477640.
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Quak, Arend. "Sprache und Kultur in der Geschichte. Beiträge des Festkolloquiums zum, written by Antje Wittstock, Martin Schubert." Amsterdamer Beiträge zur älteren Germanistik 76, no. 1 (April 4, 2016): 148–49. http://dx.doi.org/10.1163/18756719-12340008.
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Wilson, Peter H. (Peter Hamish). "The Later Thirty Years War: From the Battle of Wittstock to the Treaty of Westphalia (review)." Journal of Military History 68, no. 2 (2004): 586–87. http://dx.doi.org/10.1353/jmh.2004.0082.
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Niekerk, Carl. "Der Fall Esra. Ein Roman vor Gericht. Über die neuen Grenzen der Literaturfreiheit by Uwe Wittstock." German Studies Review 37, no. 2 (2014): 473–75. http://dx.doi.org/10.1353/gsr.2014.0050.
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König, Fritz H. "Uwe Wittstock: Über die Fähigkeit zu trauern. Das Bild der Wandlung im Prosawerk von Christa Wolf und Franz Fühmann." GDR Bulletin 14, no. 1 (October 17, 1988): 43–46. http://dx.doi.org/10.4148/gdrb.v14i1.849.
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Tanzer, Harald. "Wittstock, Uwe: Von der Stalinallee zum Prenzlauer Berg. Wege der DDR-Literatur 1949- 1989. München : Piper, 1989. - ISBN 3- 492-11136-X. 304 Seiten, DM 19,80." Informationen Deutsch als Fremdsprache 17, no. 5-6 (December 1, 1990): 680–82. http://dx.doi.org/10.1515/infodaf-1990-175-691.
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Palanisamy, Krishnaveni, Sven Daboss, Fatemehsadat Rahide, Sonia Dsoke, and Christine Kranz. "In Situ Analytical Techniques: Solid Electrolyte Interface Analysis of Al Anode Materials for Al-Ion Batteries." ECS Meeting Abstracts MA2022-02, no. 1 (October 9, 2022): 97. http://dx.doi.org/10.1149/ma2022-02197mtgabs.
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Rechargeable post Li-ion batteries based on aluminum (Al) are gaining attention due to high abundance of Al, the high theoretical volumetric capacity, and high safety associated with the low flammability [1,2]. In comparison to Li-ion batteries (LiBs), where the solid-electrolyte interphase (SEI) has been studied for decades, little is known on SEI formation in dependence of the used electrolyte for Al electrodes. In this study, we present the electrochemical performance of Al foils with two different thicknesses (0.025 mm and 0.075 mm), which were used as negative electrode in Al-ion batteries in AlCl3/1-ethyl-3-methylimidazolium chloride [EMIm]Cl electrolyte. Atomic force microscopy (AFM) was used to determine changes in the morphology of Al foils during the charge - discharge process to obtain information on the SEI and its microstructural morphology [3]. Spatially-resolved information on the electrochemical activity of interphase layers on cycled Al foils can be obtained via scanning electrochemical microscopy (SECM), which so far has only be studied at LiBs [4]. First results reveal the correlation between the morphological changes of SEI layer during cycling and its electrochemical behavior depending on the Al foil surface properties, which will be presented and discussed in this contribution. Key words: Al foil, AFM, microstructure, SEI layer, SECM. References: Meng-Chang Lin, Ming Gong, Bingan Lu, Yingpeng Wu, Di-Yan Wang, Mingyun Guan, Michael Angell, Changxin Chen, Jiang Yang, Bing-Joe Hwang and Hongjie Dai, Nature, 520, 325–328 (2015). Li, and N.J. Bjerrum, J. Power Sources, 110, 1–10 (2002). Feng Wu, Na Zhu, Ying Bai, Yaning Gao, and Chuan Wu, Green Energy & Environment 3, 71-77, (2018). Bastian Krueger, Luis Balboa, Jan Frederik Dohmann, Martin Winter, Peter Bieker and Gunther Wittstock. ChemElectroChem,7, 3590–3596, (2020). This work contributes to the research performed at CELEST (Center for Electrochemical Energy Storage Ulm-Karlsruhe) and was funded by the German Research Foundation (DFG) under Project ID 390874152 (POLiS Cluster of Excellence).
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Muhly, Paul S., and Qiyuan Na. "Extension of completely bounded A-B bimodule maps." Glasgow Mathematical Journal 36, no. 2 (May 1994): 145–55. http://dx.doi.org/10.1017/s0017089500030688.
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AbstractIn this paper, we present an “order” characterization of completely bounded bimodule maps for bimodules over unital operator algebras. We use this result to prove a bimodule generalization of Wittstock's generalized Hahn-Banach theorem. Our proofs simplify and unify some of Wittstock's arguments.
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Jarosinska, Elzbieta, Zuzanna Zambrowska, and Emilia Witkowska Nery. "Antifouling Strategies for Electrochemical Sensors in Cell Culture Application." ECS Meeting Abstracts MA2022-01, no. 53 (July 7, 2022): 2223. http://dx.doi.org/10.1149/ma2022-01532223mtgabs.
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Electrode fouling is one of the main challenges encountered during electrochemical measurements of biological material. This process takes place at the electrode surface and negatively affects analytical parameters of the sensors[1]. The impermeable layer is formed through nonspecific adsorption and polymerization or precipitation of fouling agents, such as: proteins, lipids, phenols or neurotransmitters. There are several antifouling strategies employed to protect the surface based on the hydrophobic or zwitterionic molecules, formation of a physical barrier or chemical modification of the surface with self-assembled monolayers, polymers or hydrogels[2,3]. Antifouling material should be biocompatible, naturally inert and continuously protect the electrode in a complex environment as blood, urea, sweat or wastewater[2]. Electrochemical sensors can be used for monitoring of oxygen and glucose consumption in cell cultures. In long term measurement, where sensors are permanently incorporated into cell culture matrix, oxygen and glucose sensors provide information about cell viability that can be translated to toxicity during tests of new drugs. For such systems electrodes need to withstand prolonged (at least 3-4 weeks) contact with the cell culture matrix and the surrounding medium, thus biofouling is a major issue. We have tested antifouling layers including major strategies: coating with polymers (e.g. Nafion®, phenylenediamine, polyvinyl chloride, polysilicate matrix), hydrogels (e.g. polyhydroxyethyl methacrylate), proteins (e.g. albumin), polyethylene glycol and poly-L-lactic acid. Electrodes were first coated with syringaldazine, which is easily adsorbed on carbon surfaces and provides facile to interpret response towards pH changes[4]. It is also very stable in buffer solutions but quickly desorbs in more complex media, thus making it an excellent probe for measurement of beneficial impact of antifouling layers. Tests were first conducted on macro- glassy carbon electrodes and later on low-cost pencil based sensors (250 µm diameter) as it was shown that some layers are less stable due to the big size of the electrode surface. It was revelated that polysilicate matrix, poly-L-lactic acid, polyhydroxyethyl methacrylate are suitable candidates for antifouling layers for electrochemical sensors. All three were tested as sensors in HELA cell culture, assessing cell growth on the layers and around the electrodes. Stability of the layers was evaluated during three weeks of cell culture. References: Lin PH., Li BR., Analyst, 2020, 145, 1110 Hassen B.L., Siraj S., Wong D.K.Y., Rev. Anal. Chem., 2016; 35(1): 1–28 Campuzano S. et al., Int. J. Mol. Sci. 2019, 20, 423 M. Michalak, M. Kurel, J. Jedraszko, D. Toczydlowska, G. Wittstock, M. Opallo, W. Nogala, Analytical Chemistry, 2015, 87, 23, 11641–11645 Authors acknowledge financial support of the National Centre for Research and Development under the grant LIDER/38/01381/L-9/17/NCBR/2018, and EWN would like to also thank the Foundation for Polish Science (FNP), from which she was supported through START programme and National Science Centre Poland for the MINIATURA grant NCN 2017/01/X/ST4/00463
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Oezaslan, Mehtap, Alexandra Dworzak, Christoph Mahr, Paul Paciok, Andreas Rosenauer, and Marc Heggen. "Effect of the Potentiostatic and Potentiodynamic Dealloying on the Structure and Chemical Distribution of Ag Atoms in Au-Enriched Nanoparticles." ECS Meeting Abstracts MA2022-02, no. 13 (October 9, 2022): 795. http://dx.doi.org/10.1149/ma2022-0213795mtgabs.
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Recently, nanoporous gold (np-Au) prepared by dealloying has emerged as an efficient and durable catalyst for electrochemical oxidation of small alcohols. [1] An additional increase of surface-to-volume ratio by nano-sizing of AuxAg1-x master alloy might improve the catalytic methanol oxidation reaction (MOR). Only few research groups have recently shown that the morphology, structure and elemental distribution of dealloyed nanoparticles (NPs) depend on the various parameters such as initial particle size and composition.[2-4] Starting from AuxAg1-x alloy NPs, it is, however, unclear how the different dealloyed Au-rich NP motifs such as core-shell, hollow or porous NPs and the Ag distribution influence the catalytic MOR performance. In this work, we have investigated the effects of potentiodynamic and potentiostatic dealloying methods on the structure and chemical distribution of the residual Ag atoms for dealloyed Au-rich NPs. First, two size types of Ag-rich AuxAg1-x alloy NPs were prepared by one pot colloidal route and wet impregnation route. Larger Au23Ag77 NPs (size of 77 ± 26 nm) form a homogeneous disordered alloy, while the Au14Ag86 NPs with a size of 12 ± 5 nm show a strong enrichment of Ag atoms at the particle surface, referred to as core-shell arrangement. Subsequently, the as-prepared NPs with two sizes (12 nm and 77 nm) were electrochemically dealloyed using a potentiodynamic (cyclic voltammetry, CV) or potentiostatic (chronoamperometry, CA) method in 0.1 M HClO4. We observed that the CV method leads to the formation of pores inside the initial 77 nm NPs. Very interestingly, high-resolution STEM-EDX shows the appearance of Ag-rich regions near to the pore network of these dealloyed NPs. Unlike, after the dealloying by CV method the initial 12 nm NPs are still dense and solid, forming a thin Au-rich particle shell. After the exposure to air, the internal Ag atoms tend to segregate to the particle surface. In the CA method, we pointed out that the applied anodic potential has a strong influence of the surface diffusion behavior of the remaining Au atoms. Below a critical potential of 1.3 V vs. RHE, the dealloying process is kinetically hindered by the passivation of Au surface atoms. This critical potential in the CA method is strongly different to the critical dissolution potential of Ag atoms for AgxAu1-x NPs obtained from the CV profile (around 1.05 V vs. RHE). However, when the applied potential is larger than the critical potential, e.g. 1.6 V vs. RHE, the difference in the obtained structure and composition of dealloyed 77 nm NPs is negligible between potentiodynamic and potentiostatic approaches. On the other hand, the potentiostatic dealloying at 1.6 V vs. RHE leads to higher surface content of residual Ag for dealloyed NPs with 12 nm compared to potentiodynamic. This increased enrichment of the residual Ag atoms near the particle surface is also supported by XPS. In summary, we correlate the structural parameters (initial particle size, composition/distribution) of dealloyed AgxAu1-x NPs with the electrochemical dealloying methods (potentiostatic vs. potentiodynamic). Tailoring the surface diffusion rate of the Au atoms and the Ag distribution helps to improve the catalytic performance for MOR. References: [1] Graf, Haensch, Carstens, Wittstock, Weissmüller, Nanoscale 2017, 9, 17839-17848. [2] Oezaslan, Heggen, Strasser, JACS 2012, 134, 514-524. [3] Li, Chen, Sieradzki, NanoLett 2014, 14, 2569-2577. [4] Rurainsky, Garz ́on Manjon, Hiege, Chen, Scheu, Tschulik, J. Mater. Chem. A, 2020, 8, 19405.
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Puchianu, Carmen Elisabeth. "Rumänische Realität surrealistisch verkörpert: Joachim Wittstocks Erzählung Hades, (m)eine postmoderne Lesart." Germanistische Beiträge 44, no. 1 (June 1, 2019): 41–58. http://dx.doi.org/10.2478/gb-2019-0002.
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Abstract Our analysis of Joachim Wittstock’s narrative entitled Hades and published thirteen years after the fall of the communist regime in Romania aims at pointing out the intimate connection between socio-political reality and personal experience reflected by the creative process of turning reality into fiction by writing. We consider the chosen narrative both as a political and literary statement, reflecting much of the way of life in Romania during the late 1980s. The narrative may be considered as some kind of withheld fiction and a pertinent comment of the author as to the role of fiction in a totalitarian regime.
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Wipfler, K., X. Han, S. S. H. Park, K. Wittstock, and K. Michaud. "POS0344 RISK OF ACPA POSITIVITY BY MOTIF-BASED CLASSIFICATION OF HLA-DRB1 SHARED EPITOPE ALLELES IN RA." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 401.1–401. http://dx.doi.org/10.1136/annrheumdis-2021-eular.153.
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Background:The shared epitope (SE) is the strongest known genetic risk factor for rheumatoid arthritis (RA) and is associated with an amino acid motif at positions 70-74 in HLA-DRB1. It is linked to anti-citrullinated protein antibody (ACPA) positivity, a specific serological marker for RA. In 2005, a new classification of HLA-DRB1 alleles was proposed, in which each allele is sorted into one of five classes (S1, S2, S3P, S3D, or X).1 The method was subsequently validated for predicting risk of developing RA2 and was described as “a major advance and a template for future studies.”3 However, there have been relatively few studies utilizing this classification.Objectives:To characterize the prevalence of each SE genotype from the 2005 classification and their association with ACPA positivity in a cohort of individuals with RA.Methods:Participants in FORWARD, The National Databank for Rheumatic Diseases, with RA and donated serum (collected 2010-2019) were analyzed to obtain ACPA status and high-resolution HLA-DRB1 type. Alleles were classified based on the presence (S2, S3P) or absence (S1, S3D, X; collectively L) of the SE motif, and individuals were classified by allele pair. Logistic regression models (adjusted for age, sex, and race/ethnicity) to determine risk of ACPA positivity by class were generated using L/L as the reference.Results:Characteristics of the 855 participants at the time of sample collection are presented in Table 1. Overall, 67% of participants were SE positive and 51% were ACPA positive. Of the 1,710 total alleles, X was the most common (29%) followed by S3P (24%), S1 (18%), S2 (18%), and S3D (9%). Adjusted models showed that the risk of ACPA positivity was highest among those with the genotype S2/S3P, followed by S2/S2, S2/S3D, S2/X, S3P/S3D, S1/S2, S3P/S3P, S3P/X, and S1/S3P (Figure 1).Table 1.Characteristics of study population by SE status and allele count (mean [SD] or n [%]). Significance was assessed by Student’s t-test or Χ2 test, as appropriate.SE negativeSE positiveP (SE- vs SE+)0 allelesAll1 allele2 allelesn=286n=569n=407n=162Age, years57.4 (12.3)58.1 (11.8)58.0 (11.9)58.5 (11.5)0.42RA duration, years15.2 (12.8)17.0 (13.9)16.8 (14.1)17.6 (13.4)0.07Female259 (90.6)500 (87.9)359 (88.2)141 (87.0)0.24White260 (90.9)525 (92.3)372 (91.4)153 (94.4)0.49History of smoking117 (40.9)223 (39.2)166 (40.8)57 (35.2)0.63RDCI, 0-92.4 (1.8)2.0 (1.7)2.1 (1.7)1.9 (1.7)<0.01ACPA positive74 (25.9)365 (64.1)241 (59.2)124 (76.5)<0.001RF positive84 (29.4)333 (58.5)219 (53.8)114 (70.4)<0.001Pain VAS, 0-104.2 (2.7)3.6 (2.7)3.7 (2.6)3.5 (2.9)<0.01Patient global severity, 0-104.0 (2.5)3.3 (2.5)3.4 (2.4)3.1 (2.6)<0.001HAQ-II, 0-31.0 (0.7)0.8 (0.6)0.8 (0.6)0.8 (0.6)<0.001csDMARD use204 (71.3)433 (76.1)302 (74.2)131 (80.9)0.13bDMARD use165 (57.7)351 (61.7)244 (59.95)107 (66.0)0.26Corticosteroid use98 (34.3)165 (29.0)121 (29.7)44 (27.2)0.12Figure 1.Risk of ACPA positivity by the motif-based classification and prevalence of SE by binary status, allele count, and class. The area within each circle is proportionate to the sample size of that group.Conclusion:The ranking by risk of ACPA positivity among this RA cohort is similar to the order of risk for developing RA, as determined in the 2006 validation paper for this classification method. A notable trend among the classes with one SE positive allele is the consistent ranking of S3D as higher risk, X in the middle, and S1 as the lowest, suggesting a potential protective effect from S1 alleles. Future work should examine clinical associations with these allele classes, including disease progression and treatment effects.References:[1]du Montcel, ST et al. New classification of HLA-DRB1 alleles supports the shared epitope hypothesis of rheumatoid arthritis susceptibility. Arthritis Rheum52, 1063–1068 (2005).[2]Michou, L et al. Validation of the reshaped shared epitope HLA-DRB1 classification in rheumatoid arthritis. Arthritis Res Ther8, R79 (2006).[3]Winchester, R. Reshaping Cinderella’s slipper: the shared epitope hypothesis. Arthritis Res Ther8, 109 (2006).Acknowledgements:This study was sponsored by Bristol Myers Squibb.Disclosure of Interests:Kristin Wipfler: None declared, Xue Han Employee of: Bristol Myers Squibb, Sarah (Sang Hee) Park Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Keith Wittstock Employee of: Bristol Myers Squibb, Kaleb Michaud: None declared
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Harrold, L., K. Wittstock, S. Kelly, S. H. Park, X. Han, Y. Shan, C. Roberts-Toler, N. Middaugh, and V. Khaychuk. "AB0202 IMPROVEMENT IN CLINICAL DISEASE ACTIVITY AND PATIENT-REPORTED OUTCOMES AFTER 6 MONTHS OF TREATMENT WITH ABATACEPT, STRATIFIED BY LINE OF THERAPY, IN PATIENTS WITH RA: RESULTS FROM A LARGE, US, NATIONAL OBSERVATIONAL STUDY." Annals of the Rheumatic Diseases 80, Suppl 1 (May 19, 2021): 1125–26. http://dx.doi.org/10.1136/annrheumdis-2021-eular.701.
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Background:RA is more responsive to treatment in the early stages of disease, and early treatment may lead to better long-term outcomes.1,2 Data on the effectiveness of specific drugs as first or later lines of therapy will help inform treatment sequencing.Objectives:Data from patients enrolled in the Corrona RA Registry were used to compare the effectiveness of abatacept across lines of therapy overall (primary cohort) and in a subset of patients who were anti-citrullinated protein antibody positive (ACPA+).Methods:Patients with RA who initiated abatacept (January 2006 to October 2020), had 6 months’ follow-up (within 4−9 months of starting abatacept), had baseline (BL) and follow-up CDAI scores available, and had BL CDAI >2.8 were included. Outcomes were compared for first-, second- and third or higher-line therapy: 0, 1 or ≥2 prior biologic DMARDs or Janus kinase inhibitors, respectively. Continuous outcomes included change from BL to 6 months in mean CDAI and patient-reported pain, fatigue, and HAQ. Binary outcomes included rate of achieving minimal clinically important difference (MCID) in CDAI or modified ACR20/50/70 at 6 months. Continuous and binary outcomes were analysed using multiple linear and logistic regression, respectively. The models included line of therapy, age, sex, disease duration, work status, SC nodules, history of hypertension and depression, BL CDAI, BL patient-reported pain and BL fatigue. Additional subgroup analyses were carried out in patients with moderate/high disease activity (CDAI >10) at BL.Results:In total, 2876 patients (2327 with BL CDAI >10; 890 ACPA+) were included; 442, 911, and 1523 patients initiated first-, second- or third/higher-line abatacept, respectively. Compared with patients on second/third/higher-line abatacept therapy, those on first-line abatacept were significantly older, had shorter disease duration, and had lower BL CDAI, pain and fatigue (all p<0.001). In adjusted analyses, patients receiving abatacept as earlier lines of therapy had significantly greater improvement from BL in mean CDAI and in patient-reported fatigue and HAQ (Table 1). There was no significant difference between lines of therapy in change in patient-reported pain. Patients receiving first-line abatacept had significantly higher odds of achieving a MCID in CDAI or modified ACR20/50/70 response (Figure 1). Similar patterns were seen when the sample was limited to patients with moderate/high disease activity or in patients who were ACPA+.Conclusion:There were significant differences in improvement in clinical disease activity and patient-reported outcomes across lines of therapy. Better treatment responses were observed with earlier lines of abatacept therapy in the overall population, in patients who were ACPA+ and in those with moderate/high BL disease activity.References:[1]Harrold LR, et al. Clin Rheumatol 2017;36:1215−1220.[2]Monti S, et al. RMD Open 2015;1(Suppl 1):e000057.Table 1.Adjusted mean change in CDAI and patient-reported outcomes from BL to 6 months after initiation of abatacept by line of therapy (primary cohort)Adjusted outcome, mean change (SE)First-line (n=440)Second-line (n=898)Third/higher-line (n=1515)p valueaCDAI−7.96 (0.33)−7.49 (0.27)−5.74 (0.19)<0.001Patient-reported pain (VAS 0–100)−9.43 (0.69)−7.98 (0.47)−7.70 (0.35)0.074Patient-reported fatigue (VAS 0–100)−7.49 (0.71)−5.87 (0.51)−4.81 (0.36)0.002Patient-reported HAQ−0.16 (0.01)−0.12 (0.01)−0.08 (0.01)<0.001aEstimated by multiple linear regression model adjusted for age, sex, disease duration, work status, SC nodules, history of hypertension and depression, BL CDAI, BL patient-reported pain and BL fatigue (factors that were identified a priori based on clinical experience or that differed significantly by line of therapy); p values reflect ANOVA overall test of differences across lines of therapy.VAS=visual analogue scale.Acknowledgements:Professional medical writing and editorial assistance was provided by Claire Line, PhD, at Caudex and was funded by Bristol Myers Squibb. The poster was a collaborative effort between Corrona and Bristol Myers Squibb, with financial support provided by Bristol Myers Squibb. This study was sponsored by Corrona, LLC. Corrona is supported through contracted subscriptions with multiple pharmaceutical companies.Disclosure of Interests:Leslie Harrold Consultant of: AbbVie, Bristol Myers Squibb, Genentech/Roche, Grant/research support from: Pfizer, Keith Wittstock Employee of: Bristol Myers Squibb, Sheila Kelly Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Sang Hee Park Employee of: Bristol Myers Squibb, Xue Han Employee of: Bristol Myers Squibb, Ying Shan: None declared, Carla Roberts-Toler: None declared, Nicole Middaugh: None declared, Vadim Khaychuk Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb
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Wang, C. A., R. Wong, T. D. Kou, H. Zheng, K. Wittstock, V. Khaychuk, and V. Patel. "POS0343 TREATMENT PERSISTENCE AND ADHERENCE AMONG PATIENTS WITH JUVENILE IDIOPATHIC ARTHRITIS RECEIVING ABATACEPT OR TNF INHIBITORS USING US CLAIMS DATA." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 425. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1289.
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BackgroundJuvenile idiopathic arthritis (JIA) is the most common rheumatic condition among children and teens1 and contributes to a diminished quality of life.2 Previous data underscore the potential for abatacept to improve health-related outcomes in patients with JIA after demonstrating poor responses to other DMARDs.3 Patients with RA show greater persistence on abatacept vs TNF inhibitors (TNFi), and this should also be confirmed in patients with JIA.4ObjectivesTo evaluate treatment persistence and adherence at 12- and 18-month follow-up in patients with JIA newly initiating either abatacept or a TNFi.MethodsThis analysis used data from the IQVIA PharMetrics Plus claims database from Jan 2008–Apr 2021. We identified patients with ≥ 1 claim of JIA diagnosis after Jan 2008, who were < 18 years old at initial diagnosis, had ≥ 1 claim of abatacept or TNFi treatment (adalimumab, etanercept, golimumab) following diagnosis, had continuous enrollment in medical and pharmacy benefits for ≥ 12 months before index date (first prescription of abatacept or TNFi), and had 12 or 18 months’ continuous medical and pharmacy enrollment after index date. Patients receiving abatacept or TNFi treatment ≤ 12 months prior to index date and patients initiating combined abatacept + TNFi treatment on the index date were excluded. Specific outcomes included: discontinuation (absence of a new prescription for index treatment within the gap of 5× treatment half-life), persistence rate (proportion of patients continuing index medication without any gaps exceeding 5× treatment half-life), and treatment adherence (defined as medication possession ratio [MPR, proportion of follow-up period where medication supply is available] and proportion of days covered [PDC, proportion of follow-up period where a patient is covered by a given drug]). All outcomes were reported at 12 and 18 months. All statistical analyses are descriptive with the intent for hypothesis generation.ResultsThere were 2847 patients (abatacept, n = 111; TNFi, n = 2736) at 12-month follow-up; fewer completed the 18-month follow-up (2403 patients: abatacept, n = 94; TNFi, n = 2309). At index date, treatment groups were similar for sex, geographic location, and comorbidities (Table 1). Numerically higher persistence was observed in patients prescribed abatacept compared with TNFi overall at both time points. Abatacept persistence was higher than etanercept but similar to adalimumab (Figure 1). At 12 months, the percent of patients with PDC ≥ 0.8 was 57% for abatacept, 51% for adalimumab, and 38% for etanercept, while MPR ≥ 0.8 was 63% for abatacept, 55% for adalimumab, and 42% for etanercept. Patients prescribed abatacept had numerically greater proportions of PDC ≥ 0.8 (abatacept, 48%; adalimumab, 40%; etanercept, 29%) and MPR ≥ 0.8 (abatacept, 53%; adalimumab, 44%; etanercept, 33%) at 18 months.Table 1.Baseline characteristics of patients with 12-month follow-up dataCharacteristicAbatacept (n = 111)TNFi (n = 2736)Age, years, mean (SD)14.4 (3.8)12.6 (4.6)Female sex89 (80.2)1930 (70.5)Geographic region South43 (38.7)865 (31.6) Midwest40 (36.0)818 (29.9) West9 (8.1)408 (14.9) East19 (17.1)540 (19.7) Unknown0 (0)105 (3.8)Comorbidities Asthma9 (8.1)275 (10.1) COPD11 (9.9)323 (11.8) Cardiovascular disease14 (12.6)222 (8.1) Uveitis14 (12.6)321 (11.7) Iridocyclitisa12 (10.8)216 (7.9)CCI score, mean (SD)0.58 (0.73)0.46 (0.68)Data are shown as n (%) unless otherwise specified.aSubgroup disease under uveitis.CCI, Charlson Comorbidity Index; COPD, chronic obstructive pulmonary disease.ConclusionThe present findings suggest that patients with JIA initiating abatacept treatment display numerically higher persistence and adherence compared with patients treated with TNFis at both 12- and 18-months’ follow-up.References[1]Prakken B, et al. Lancet 2011;377:2138–49.[2]Lovell DJ, et al. Arthritis Rheumatol 2015;67:2759–70.[3]Ruperto N, et al. Lancet 2008;372:383–91.[4]Han X, et al. J Health Econ Outcomes Res 2021;8:71–8.AcknowledgementsThis study was sponsored by Bristol Myers Squibb. Medical writing and editorial assistance were provided by Ryan Miller, of Caudex, and were funded by Bristol Myers Squibb. Project analysis was provided by Akshay Vinod (Mu Sigma).Disclosure of InterestsChing-An Wang Consultant of: Novartis (used to work there as an external contractor from Jan 2016 to Apr 2021), Employee of: Bristol Myers Squibb, Robert Wong Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Tzuyung Douglas Kou Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Hanke Zheng Employee of: Bristol Myers Squibb, Keith Wittstock Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Vadim Khaychuk Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb, Vardhaman PATEL Shareholder of: Bristol Myers Squibb, Employee of: Bristol Myers Squibb
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Ailes, Mary Elizabeth. "On the Verge of War: International Relations and the Jülich‐Kleve Succession Crises, 1609–1614. By Alison D. Anderson. Studies in Central European Histories. Edited by, Thomas A. Brady Jr. and Roger Chickering. Boston: Humanities Press, 1999. Pp. xvi+276. $86.00.The Later Thirty Years War: From the Battle of Wittstock to the Treaty of Westphalia. By William P. Guthrie. Contributions in Military Studies, number 222. Westport, CT: Greenwood Press, 2003. Pp. x+307. $69.95." Journal of Modern History 77, no. 2 (June 2005): 392–94. http://dx.doi.org/10.1086/431822.
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Franklin, Giovanna Formiga, Omar Hassan, El-Mahdi Halim, Pierre-Louis Taberna, Patrice Simon, and Florence Duclairoir. "Electrochemical Development and Characterization By SECM of 2D Carbon-Based Materials Architectured for Energy Storage and Conversion." ECS Meeting Abstracts MA2022-01, no. 12 (July 7, 2022): 840. http://dx.doi.org/10.1149/ma2022-0112840mtgabs.
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With the fastly-growing social and commercial demands for portable electronic devices and the need for developing environmentally friendly high-power energy sources, new non-critical, non-toxic materials are currently being widely studied [1]. Electrochemical Double Layer Capacitors, also termed as supercapacitors, store energy electrostatically by charge separation at the high-surface-area porous carbon / electrolyte interface, by charging the electrochemical double layer [2]. Carbon-based materials are the most widely used electrode materials for EDLCs because of their desirable physical-chemical properties and low cost. Out of the various carbon structures explored as electrode materials, graphene appears to be a promising candidate thanks to its key properties [3]. In this work, in-depth electrochemical characterizations of 2-Dimensional graphene-based materials was achieved using Scanning Electrochemical Microscopy (SECM) technique to study local electrochemical properties: ionic transport and charge transfer properties. 2D carbon materials with tuned interlayer distance were prepared by bridging reduced graphene oxide (rGO) sheets using hexanediamine electroactive molecules acting as pillars. Pillared and non-pillared porous graphene hydrogel (6GH and GHG respectively) composed were also synthetized and tested. Those measurements gave insights about the electroactivity and conductivity of the material’s surface. Also, the influence of the nature and lengths of the pillar on the electrochemical performance have been studied. Preliminary results using conventional electrochemical techniques show that the specific capacitance of raw GHG (170 F g-1) was reduced down to 70F g-1 when adding 6 carbons-hexanediamine pillars during its hydrothermal synthesis to prepare the 6GH (pillared graphene hydrogel). For the rGO, the addition of pillars with different lengths resulted in an increase of specific capacitance from 100 F g-1 to rGO to 140 F g-1 for rGO pillared with 7 atoms pillar diamine pillar (7RP) and 130 F g-1 for rGO pillared with 8 atoms diamine pillar (8RP) . Then, SECM experiments in feedback mode allowed for a fast comparison of the change in local electrochemical activity for the different surfaces through redox reactions between the tip and the electrode surface for all developed materials. Fitting measured approach curves to simulated ones can be used to estimate rate coefficients, as suggested by Chang, Mirkin and Bard [5]. The effective rate coefficient (keff) values for the mediator regenerating surface reaction were estimated using Wittstock's method by fitting the approach curves recorded at different positions. A 10µm diameter platinum-disc microelectrode was the tip connected to the Bio-Logic SECM-150 bipotentiostat and responsible for the approach curve measurement. For the GHG, it was found a 2.3 10-2 cm s-1 effective constant, which is reduced to 1.6 1.8 10-2 cm s-1 for the 6GH. For the rGO, the keff has the value of 3.3 10-2 cm s-1. The next step is to define the effective constant for the pillared rGO 7RP and 8RP. This study contributed to define the key characteristics allowing for the use of electrodes for supercapacitors offering optimal performance in energy density and power density. 1- Zhang, Li Li; Zhao, X. S. Carbon-based materials as supercapacitor electrodes. , 38(9), 2520–0, 2009. 2- Jiang Yang, Sundaram Gunasekaran. Electrochemically reduced graphene oxide sheets for use in high performance supercapacitors,Carbon, 2013. 3- Zhu, Y.; Murali, S.; Stoller, M. D.; Ganesh, K. J.; Cai, W.; Ferreira, P. J.; Pirkle, A.; Wallace, R. M.; Cychosz, K. A.; Thommes, M. Carbon-Based Supercapacitors Produced by Activation of Graphene, 2011. 4-TAKAHASHI, Yasufumi. Development of High-Resolution Scanning Electrochemical Microscopy for Nanoscale Topography and Electrochemical Simultaneous Imaging. Electrochemistry, 2016. 5- C. Wei, A.J. Bard, M.V. Mirkin, Scanning electrochemical microscopy. 31. Application of SECM to study of charge transfer processes at the liquid/liquid interface, J. Phys. Chem. 99 Figure 1
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Probst, Inga. "‚Social Turn‘ vor der Wende? Helke Misselwitz’ und Volker Koepps filmische Sozialdiagnosen." Convivium. Germanistisches Jahrbuch Polen, December 28, 2018, 111–28. http://dx.doi.org/10.18778/2196-8403.2018.06.
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Helke Misselwitz’ Dokumentarfilm Winter adé (1988) und Volker Koepps siebenteilige Langzeitdokumentation des Wittstock Zyklus (1974-1997) sind bislang zumeist aus dem genderkritischen Blickwinkel des filmischen Frauenportraits analysiert worden. Diese Perspektive ausweitend, untersucht der vorliegende Artikel, inwiefern die Filme sozialdiagnostische Auskunft über Ungleichheit in der späten DDR geben. Diskutiert wird, ob diese Filme als Dokumente eines ‚Social Turns‘ geltend gemacht werden können, der sich schon vor dem großen Strukturwandel der 1990er-Jahre ankündigt.
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"Volker Wittstock ist Lothar‐Cremer‐Preisträger 2009." Bauphysik 31, no. 3 (June 2009): 196. http://dx.doi.org/10.1002/bapi.200990022.
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Schopper, Franz. "Seddin, Freyenstein and Wittstock. Research, presentation and sustainable site management in Northern Brandenburg." Internet Archaeology, February 28, 2020. http://dx.doi.org/10.11141/ia.54.5.
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Brandenburg State Authorities for Heritage Management and State Museum of Archaeology, together with local authorities, developed a project, to integrate various important archaeological sites into a shared cultural tourism concept – thus the Prignitz Archaeological Route was formed. This article highlights three of the seven sites that are included in the project: the Bronze Age grave mound from 800 BCE at Seddin, the abandoned town of the 12th and 13th century in Freyenstein and the battlefield from 1636 near Wittstock. Each place had to apply three main approaches: heritage management, research and tourism development.
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Gottwald, Herwig. "Uwe Wittstock, Leselust. Wie unterhaltsam ist die neue deutsche Literatur? Ein Essay." Arbitrium 15, no. 2 (1997). http://dx.doi.org/10.1515/arbi.1997.15.2.268.
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Gantet, Claire. "'Sieber, Andrea, Wittstock, Antje, Melancholie – zwischen Attitüde und Diskurs. Konzepte in Mittelalter und Früher Neuzeit'." Revue de l’Institut français d’histoire en Allemagne, January 1, 2011. http://dx.doi.org/10.4000/ifha.6577.
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Lamping, Dieter. "Wilfried Wittstruck, Der dichterische Namengebrauch in der deutschen Lyrik des Spätmittelalters." Arbitrium 7, no. 1 (1989). http://dx.doi.org/10.1515/arbi.1989.7.1.48.
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