We are proudly a Ukrainian website. Our country was attacked by Russian Armed Forces on Feb. 24, 2022.
You can support the Ukrainian Army by following the link: https://u24.gov.ua/.
Even the smallest donation is hugely appreciated!
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Wide life.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Chang, Chew-Hung, and Gillian Kidman. "Life-long and life-wide education for our sustainable future." International Research in Geographical and Environmental Education 31, no. 2 (April 3, 2022): 85–88. http://dx.doi.org/10.1080/10382046.2022.2057895.
Rogers, Rebecca. "Understanding Literacy Development “Lifelong and Life Wide”." Reading Research Quarterly 46, no. 1 (January 3, 2011): 86–96. http://dx.doi.org/10.1598/rrq.46.1.5.
Veatch, Robert M. "Limiting life support: A world-wide consensus? *." Critical Care Medicine 32, no. 2 (February 2004): 597–98. http://dx.doi.org/10.1097/01.ccm.0000110662.17035.76.
Ravindran, Aisha. "Splitting a Life Wide Open: Poetic Auto/Biography and Life Narratives." International Journal of the Humanities: Annual Review 8, no. 9 (2010): 49–62. http://dx.doi.org/10.18848/1447-9508/cgp/v08i09/43029.
Pamphilon, Barbara. "HOW AGED WOMEN REMEMBER THEIR LIFE-LONG/LIFE-WIDE LEARNING: MAKING THE BEST OF LIFE." Educational Gerontology 31, no. 4 (April 20, 2005): 283–99. http://dx.doi.org/10.1080/03601270590916795.
Kay, Judy, and Bob Kummerfeld. "From data to personal user models for life‐long, life‐wide learners." British Journal of Educational Technology 50, no. 6 (September 18, 2019): 2871–84. http://dx.doi.org/10.1111/bjet.12878.
PETRUCCI, G., and B. ZUCCARELLO. "Fatigue life prediction under wide band random loading." Fatigue & Fracture of Engineering Materials & Structures 27, no. 12 (December 2004): 1183–95. http://dx.doi.org/10.1111/j.1460-2695.2004.00847.x.
Malynevskaya, K. I. "Internet in our Life." Thesis, Київський національний університет технологій та дизайну, 2017. https://er.knutd.edu.ua/handle/123456789/8442.
Keildson, Sarah. "Model selection strategies in genome-wide association studies." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:bd97c2e3-10e3-4007-9b7b-199e99d04f94.
Unravelling the genetic architecture of common diseases is a continuing challenge in human genetics. While genome-wide association studies (GWAS) have proven to be successful in identifying many new disease susceptibility loci, the extension of these studies beyond single-SNP methods of analysis has been limited. The incorporation of multi-locus methods of analysis may, however, increase the power of GWAS to detect genes of smaller effect size, as well as genes that interact with each other and the environment. This investigation carried out large-scale simulations of four multi-locus model selection techniques; namely forward and backward selection, Bayesian model averaging (BMA) and least angle regression with a lasso modification (lasso), in order to compare the type I error rates and power of each method. At a type I error rate of ~5%, lasso showed the highest power across varied effect sizes, disease frequencies and genetic models. Lasso penalized regression was then used to perform three different types of analysis on GWAS data. Firstly, lasso was applied to the Wellcome Trust Case Control Consortium (WTCCC) data and identified many of the WTCCC SNPs that had a moderate-strong association (p<10-5) type 2 diabetes (T2D), as well as some of the moderate WTCCC associations (p<10-4) that have since been replicated in a large-scale meta-analysis. Secondly, lasso was used to fine-map the 17q21 childhood asthma risk locus and identified putative secondary signals in the 17q21 region, that may further contribute to childhood asthma risk. Finally, lasso identified three potential interaction effects potentially contributing towards coronary artery disease (CAD) risk. While the validity of these findings hinges on their replication in follow-up studies, the results suggest that lasso may provide scientists with exciting new methods of dissecting, and ultimately understanding, the complex genetic framework underlying common human diseases.
3
Barrett, Jeffrey C. "Design and analysis of genome-wide association studies." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:45790b5c-e50c-406a-bb3c-a96868b11a28.
Despite many years of effort, linkage and candidate gene association studies have yielded disappointingly few risk loci for common human diseases such as diabetes, auto-immune disorders and cancers. Large sample sizes, increased understanding of the patterns of correlation in genetic variation, and plunging genotyping costs have enabled genome-wide association studies, which have good power to detect common risk alleles of modest effect. I present an evaluation of SNP choice in study design and show that overall, despite substantial differences in genotyping technologies, marker selection strategies and number of markers assayed, the first generation platforms all offer good levels of genome coverage (∼ 70%). I next describe the largest such project undertaken to date, the Wellcome Trust Case Control Consortium, which consisted of 2000 cases from each of seven common diseases and 3000 shared controls. It identified nearly two dozen new associations. I demonstrate the importance of careful data quality control, including both standard and unorthodox analyses. I next focus on the association results therein for Crohn’s disease. I present a replication experiment in over 1000 additional Crohn’s patients which unambiguously confirmed six previously published loci and four new loci. Next I describe, in a general context, several issues impeding the combination of genome-wide scans, including data annotation, population structure and differences in genotyping platform. Each of these problems is shown to be tractable with available methods, provided that these methods are applied prudently. I present the results of a meta-analysis of three genome-wide scans for Crohn’s disease. The data showed a striking excess of significant associations, and a replication experiment involving over 4000 independent Crohn’s patients verified twenty new risk loci. Finally, I discuss the early success of genome-wide association and its consequences for further understanding the biology of human disease.
4
Ridout, Kate E. "Genome-wide analysis of selection in mammals, insects and fungi." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:5a894760-9240-4e79-a50f-37547f108a00.
Characterising and understanding factors that affect the rate of molecular evolution in proteins has played a major part in the development of evolutionary theory. The early analyses of amino acid substitutions stimulated the development of the neutral theory of molecular evolution, which later evolved into the nearly neutral theory. More recent work has lead to a better understanding of the role selection plays at the molecular level, but there is still limited understanding of how higher levels of protein organisation affect the way natural selection acts. The investigation of this question is the central aim of this thesis, which is addressed via the analysis of selective pressures in secondary protein structures in insects, mammals and fungi. The analyses for the first two groups were conducted using publically available datasets. To conduct the analyses in fungi, genome sequence data from the fungal genus Microbotryum (sequenced in our laboratory) was assembled and annotated, resulting in the development of a number of bioinformatics tools which are described here. The fungal, insect and mammalian datasets were interrogated with regard to a number of structural features, such as protein secondary structure, position of a site with regard to adaptively evolving sites, hydropathy and solvent-accessibility. These features were correlated with the signals of positive and purifying selection detected using phylogenetic maximum likelihood and Bayesian approaches. I conclude that all of the factors examined can have an effect on the rate of molecular evolution. In particular, disordered and hydrophilic regions of the protein are found to experience fewer physiochemical constraints and contain a higher proportion of adaptively evolving sites. It is also revealed that positively selected residues are ‘clustered’ together spatially, and these trends persist in the three taxa. Finally, I show that this variation in adaptive evolution is a result of both selective events and physiochemical constraint.
5
Klinterhäll, Annika, and Elisabeth Green. "Sex on the table. The formation of a wide-ranging sex education." Thesis, Malmö högskola, Fakulteten för hälsa och samhälle (HS), 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-27035.
There is a settled stereotype for women and men which give them different possibilities in our society. The schools, which are one of the most important sources of knowledge, have a great possibility to influence. This is the reason why we are interested in how the schools are working with a project, which we will call X henceforth. What was the purpose with the project and what does it contain? What is missing in the former education, since the project was started? Are there any obstacles or prerequisite in the design of the project or in the school teaching on the basis of X? We have done interviews in the gathering of empirical material to find out all the answers to our questions. To support this, we have chosen a few theories which we find suitable for the material. The teacher´s and the principal find the project X very important in the development of a more open-minded pupil. They also think that the project is helping them a lot by being supported with material and knowledges how to work with the subject.
6
Bhattacharya, Kanishka. "Gene x gene interactions in genome wide association studies." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:6cb7ab29-90df-4d70-bc2f-531f874b79d0.
Genome wide association studies (GWAS) have revolutionized our approach to mapping genetic determinants of complex human diseases. However, even with success from recent studies, we have typically been able to explain only a fraction of the trait heritability. GWAS are typically analysed by testing for the marginal effects of single variants. Consequently, it has been suggested that gene-gene interactions might contribute to the missing heritability of complex diseases. GWAS incorporating interaction effects have not been routinely applied because of statistical and computational challenges relating to the number of tests performed, genome-wide. To overcome this issue, I have developed novel methodology to allow rapid testing of pairwise interactions in GWAS of complex traits, implemented in the IntRapid software. Simulations demonstrated that the power of this approach was equivalent to computationally demanding exhaustive searches of the genome, but required only a fraction of the computing time. Application of IntRapid to GWAS of a range of complex human traits undertaken by the Wellcome Trust Case Control Consortium (WTCCC) identified several interaction effects at nominal significance, which warrant further investigation in independent studies. In an attempt to fine-map the identified interacting loci, I undertook imputation of the WTCCC genotype data up to the 1000 Genomes Project reference panel (Phase 1 integrated release, March 2012) in the neighbourhood of the lead SNPs. I modified the IntRapid software to take account of imputed genotypes, and identified stronger signals of interaction after imputation at the majority of loci, where the lead SNP often had moved by hundreds of kilobases. The X-chromosome is often overlooked in GWAS of complex human traits, primarily because of the difference in the distribution of genotypes in males and females. I have extended IntRapid to allow for interactions with the X chromosome by considering males and females separately, and combining effect estimates across the sexes in a fixed-effects meta-analysis. Application to genotype data from the WTCCC failed to identify any strong signals of association with the X-chromosome, despite known epidemiological differences between the sexes for the traits considered. The novel methods developed as part of this doctoral work enable a user friendly, computationally efficient and powerful way of implementing genome-wide gene-gene interaction studies. Further work would be required to allow for more complex interaction modelling and deal with the associated computational burden, particularly when using next-generation sequencing (NGS) data which includes a much larger set of SNPs. However, IntRapid is demonstrably efficient in exhaustively searching for pairwise interactions in GWAS of complex traits, potentially leading to novel insights into the genetic architecture and biology of human disease.
7
Clemente, Batalha Pardal Diana 1990. "European-wide studies on pro-inflammatory risk factors in early life and molecular markers of aging." Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/666990.
Although universal and unavoidable, aging does not occur in a uniform way. In this dissertation, we assessed the effects of early life exposure to pro-inflammatory risk factors (air pollution and obesity) on mitochondrial DNA (mtDNA) content and telomere length, considered as markers of biological aging, at birth and during childhood. First we observed that an increment in nitrogen dioxide (NO2) exposure during pregnancy was associated with a decrease in both placental mtDNA content and birth weight and length (chapter 2 and 3). Secondly, we showed that the association between prenatal NO2 exposure and infant growth could be mediated by placental mtDNA content (chapter 2 and 3). Thirdly, our study found that increased pre- and postnatal exposure to air pollutants lead to shorter leukocyte telomere length in 8 year old children (chapter 4). Finally, we showed that increased obesity indicators were associated with significant shorter telomeres in 8 year old children (chapter 5). Tot i que és universal i inevitable, l'envelliment no es produeix de manera uniforme. En aquesta tesi, es van avaluar els efectes de l'exposició primerenca a factors de risc proinflamatoris (contaminació de l'aire i obesitat) sobre el contingut d'ADN mitocondrial (mtDNA) i la longitud del telómero, considerats com a marcadors de l'envelliment biològic, en néixer i durant la infància. En primer lloc, vam observar que un increment de l'exposició al diòxid de nitrogen (NO2) durant l'embaràs es va associar amb una disminució tant del contingut de ADN de la placenta plasmàtica com del pes i la durada del part (capítols 2 i 3). En segon lloc, vam mostrar que l'associació entre l'exposició NO2 prenatal i el creixement infantil podria estar mediada per contingut de ADN de placenta (capítols 2 i 3). En tercer lloc, el nostre estudi va descobrir que l'augment de l'exposició pre i postnatal als contaminants atmosfèrics conduir a una menor longevitat de leucòcits en nens de 8 anys (capítol 4). Finalment, vam mostrar que un augment dels indicadors d'obesitat es van associar amb telòmers més curts significatius en nens de 8 anys (capítol 5).
8
Powers, Ralph Wilson. "Genome-wide screens reveal that reduced TOR signaling extends chronological and replicative life span in S. cerevisiae /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/5044.
Sternberg, André Dirk [Verfasser], André [Akademischer Betreuer] Bardow, and Francois [Akademischer Betreuer] Maréchal. "System-wide perspective for life cycle assessment of CO2-based C1-chemicals / André Dirk Sternberg ; André Bardow, Francois Maréchal." Aachen : Universitätsbibliothek der RWTH Aachen, 2018. http://d-nb.info/1162900296/34.
Choudhry, Hani. "Genome-wide analysis of the hypoxic breast cancer transcriptome using next generation sequencing." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:9a66b553-a66c-4164-a854-5881be65ca45.
Hypoxia pathways are associated with the pathogenesis of both ischaemic and neoplastic diseases. In response to hypoxia the transcription factor hypoxia‐inducible factor (HIF) induces the expression of hundreds of genes with diverse functions. These enable cells to adapt to low oxygen availability. To date, pan-genomic analyses of these transcriptional responses have focussed on protein-coding genes and microRNAs. However, the role of other classes of non-coding RNAs, in particular lncRNAs, in the hypoxia response is largely uncharacterised. My thesis aimed at improving understanding of the transcriptional regulation of the non-coding transcriptome in hypoxia. I performed an integrated genomic analysis of both non-coding and coding transcripts by massively parallel sequencing. This was interfaced with pan-genomic analyses of DNAse hypersensitivity and HIF, H3k4me3 and RNApol2 binding in hypoxic cells. These analyses have revealed that hypoxia profoundly regulated all RNA classes. snRNAs and tRNAs are globally downregulated in hypoxia, whilst miRNAs, mRNAs and lncRNAs are both up- and downregulated with an overall trend towards slight upregulation. In addition, a significant number of previously non-annotated (and largely hypoxia upregulated) transcripts were identified, including novel intergenic transcripts and natural antisense transcripts. HIF bound close to genes for mRNAs, miRNAs and lncRNAs that were upregulated by hypoxia, but was excluded from binding at genes for RNA classes that showed global downregulation. This suggests that HIF acts as a transcriptional activator (but not repressor), of lncRNAs as well as mRNAs and miRNAs. Consistent with direct regulation by HIF, many of these hypoxia-inducible, HIF-binding lncRNAs were downregulated following HIF knockdown. Analysis of RNApol2 binding and DNAse HSS signals at HIF transcriptional target genes indicated that HIF-dependent transcriptional activation occurs through release of RNApol2 that is pre-bound to open promoters of lncRNAs as well as mRNAs. In these datasets, NEAT1 was the most hypoxia-upregulated, HIF-targeted lncRNA in MCF-7 cells and, despite binding of both HIF-1 and HIF-2 isoforms at its promoter, was selectively regulated by HIF-2 alone. Furthermore, NEAT1 was induced by hypoxia in a wide range of breast cancer cell lines and in hypoxic xenograft models. Functionally, NEAT1 is required for the assembly of nuclear paraspeckle structures. Increased nuclear paraspeckle formation was observed in hypoxia and was dependent on both NEAT1 and HIF-2. Knockdown of hypoxia-induced NEAT1 significantly reduced cell proliferation and survival and induced apoptosis. Finally, high expression of NEAT1 correlated with poor clinical outcome in a large cohort of breast cancer patients. These findings extend the role of the hypoxic transcriptional response in cancer into the spectrum of non-coding transcripts and provide new insights into molecular roles of hypoxia-regulated lncRNAs, which may provide the basis for novel therapeutic targets in the future.
Kühn, Rolf, and Michael Staudigl. "Michel Henry’s “Radical Phenomenology of Life”." In Phenomenology World-Wide, 497–500. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-007-0473-2_54.
Eng, Erling. "The Life and Work of Erwin Straus." In Phenomenology World-Wide, 665–67. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-007-0473-2_77.
Zecchi, Stefano. "Enzo Paci, the Life World from an Empirical Approach." In Phenomenology World-Wide, 479–81. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-007-0473-2_47.
Marques, Oge. "The World Wide Web." In Innovative Technologies in Everyday Life, 3–18. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-45699-7_2.
Greene, Maxine. "Wide-Awakeness and the Moral Life." In Foundations of Education, 147–54. 2nd ed. New York: Routledge, 2022. http://dx.doi.org/10.4324/9781003340362-14.
Stow, Daniel, and Chris Roadknight. "Antigens, Antibodies, and the World Wide Web." In Advances in Artificial Life, 161–65. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/3-540-44811-x_17.
Walshe, Ray, and Mark Humphrys. "First Implementation of the World-Wide-Mind." In Advances in Artificial Life, 714–18. Berlin, Heidelberg: Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/3-540-44811-x_83.
Tymieniecka, Anna-Teresa. "A Note on Edmund Husserl’s Late Breakthrough to the Plane of Nature-Life, Completing His Itinerary." In Phenomenology World-Wide, 685–87. Dordrecht: Springer Netherlands, 2002. http://dx.doi.org/10.1007/978-94-007-0473-2_81.
Quercia, Daniele, Luca Maria Aiello, Rossano Schifanella, and Adam Davies. "The Digital Life of Walkable Streets." In WWW '15: 24th International World Wide Web Conference. Republic and Canton of Geneva, Switzerland: International World Wide Web Conferences Steering Committee, 2015. http://dx.doi.org/10.1145/2736277.2741631.
Cobb, Camille, and Tadayoshi Kohno. "How Public Is My Private Life?" In WWW '17: 26th International World Wide Web Conference. Republic and Canton of Geneva, Switzerland: International World Wide Web Conferences Steering Committee, 2017. http://dx.doi.org/10.1145/3038912.3052592.
De Nadai, Marco, Jacopo Staiano, Roberto Larcher, Nicu Sebe, Daniele Quercia, and Bruno Lepri. "The Death and Life of Great Italian Cities." In WWW '16: 25th International World Wide Web Conference. Republic and Canton of Geneva, Switzerland: International World Wide Web Conferences Steering Committee, 2016. http://dx.doi.org/10.1145/2872427.2883084.
Theocharous, Georgios, Philip S. Thomas, and Mohammad Ghavamzadeh. "Ad Recommendation Systems for Life-Time Value Optimization." In WWW '15: 24th International World Wide Web Conference. New York, NY, USA: ACM, 2015. http://dx.doi.org/10.1145/2740908.2741998.
Grohens, Théotime, Sam Meyer, and Guillaume Beslon. "A Genome-Wide Evolutionary Simulation of the Transcription-Supercoiling Coupling." In The 2021 Conference on Artificial Life. Cambridge, MA: MIT Press, 2021. http://dx.doi.org/10.1162/isal_a_00434.
Ferrara, Emilio, Yong-Yeol Ahn, Yana Volkovich, and Young-Ho Eom. "Session details: Connecting online & offline life workshop (COOL 2014)." In WWW '14: 23rd International World Wide Web Conference. New York, NY, USA: ACM, 2014. http://dx.doi.org/10.1145/3254764.
Hintze, Arend, Yasir Imam, and Lars Rönnegård. "Testing the Efficiency of a Genome-Wide Association Study on a Computational Evolutionary Model." In The 2022 Conference on Artificial Life. Cambridge, MA: MIT Press, 2022. http://dx.doi.org/10.1162/isal_a_00491.
Teehan, Paul, Stefan Storey, and Milind Kandlikar. "Rapid integrated life cycle assessment of building-wide IT systems." In 2011 IEEE International Symposium on Sustainable Systems and Technology (ISSST). IEEE, 2011. http://dx.doi.org/10.1109/issst.2011.5936894.
Starkweather, Gary K. "DSHARP - a wide screen multi-projector display." In 19th Congress of the International Commission for Optics: Optics for the Quality of Life, edited by Giancarlo C. Righini and Anna Consortini. SPIE, 2003. http://dx.doi.org/10.1117/12.523805.
Hernández-Lemus, Enrique, Jesús K. Estrada-Gil, Irma Silva-Zolezzi, J. Carlos Fernández-López, Alfredo Hidalgo-Miranda, Gerardo Jiménez-Sánchez, Leonardo Dagdug, and Leopoldo Gracía-Colin S. "Nonlinear Analysis of Time Series in Genome-Wide Linkage Disequilibrium Data." In COMPLIFE 2007: The Third International Symposium on Computational Life Science. AIP, 2008. http://dx.doi.org/10.1063/1.2891412.
Ferre, Zuleika, Néstor Gandelman, and Giorgina Piani. Quality of Life in Montevideo. Inter-American Development Bank, September 2008. http://dx.doi.org/10.18235/0011268.
This paper analyzes various dimensions of the quality of life in Montevideo. The paper finds that satisfaction with various public goods and services at the neighborhood level play a minor role in the overall reported well-being of individuals and in the satisfaction of life domains, such as leisure, social life, family, health, housing, neighborhood economic situation and work. This is in spite of significant disparities in a wide range of indicators among those living in different areas of the city. The results further suggest that differences in overall happiness and in domain satisfaction are mostly due to differences in individual outcomes like education, health, labor situation and housing quality.
2
Dix, Katherine, Syeda Kashfee Ahmed, Toby Carslake, and Shani Sniedze-Gregory. Evidence of impact underpinning Life Education Programs. Life Education Australia, September 2021. http://dx.doi.org/10.37517/978-1-74286-643-7.
This rapid evaluation of core Life Education programs conducted by the Australian Council for Educational Research (ACER) in June 2021 is an independent investigation that demonstrates the evidence base underpinning Life Education programs in primary schools Australia-wide. It presents a national snapshot by drawing upon existing Life Education-specific evaluation data, existing ACER student wellbeing data, and accepted best practice in the field of student health and wellbeing education. The project addressed the key evaluation questions: How are core Life Education programs underpinned by evidence-based best practice, and how are core Life Education programs impacting primary-aged student wellbeing outcomes that align to the health and physical education Australian and State Curriculums?
3
Al-Qadi, Imad, Jaime Hernandez, Angeli Jayme, Mojtaba Ziyadi, Erman Gungor, Seunggu Kang, John Harvey, et al. The Impact of Wide-Base Tires on Pavement—A National Study. Illinois Center for Transportation, October 2021. http://dx.doi.org/10.36501/0197-9191/21-035.
Researchers have been studying wide-base tires for over two decades, but no evidence has been provided regarding the net benefit of this tire technology. In this study, a comprehensive approach is used to compare new-generation wide-base tires (NG-WBT) with the dual-tire assembly (DTA). Numerical modeling, prediction methods, experimental measurements, and environmental impact assessment were combined to provide recommendations about the use of NG-WBT. A finite element approach, considering variables usually omitted in the conventional analysis of flexible pavement was utilized for modeling. Five hundred seventy-six cases combining layer thickness, material properties, tire load, tire inflation pressure, and pavement type (thick and thin) were analyzed to obtained critical pavement responses. A prediction tool, known as ICT-Wide, was developed based on artificial neural networks to obtain critical pavement responses in cases outside the finite element analysis matrix. The environmental impacts were determined using life cycle assessment. Based on the bottom-up fatigue cracking, permanent deformation, and international roughness index, the life cycle energy consumption, cost, and green-house gas (GHG) emissions were estimated. To make the outcome of this research effort useful for state departments of transportation and practitioners, a modification to AASHTOWare is proposed to account for NG-WBT. The revision is based on two adjustment factors, one accounting for the discrepancy between the AASHTOware approach and the finite element model of this study, and the other addressing the impact of NG-WBT.
4
Wilcove, Gerry L. Quality of Life in the Navy, Findings from 1990 to 1992: The Navy-Wide Personnel Survey. Volume 2. Management Report. Fort Belvoir, VA: Defense Technical Information Center, February 1994. http://dx.doi.org/10.21236/ada277257.
Cooke. L51783 100000 Hour Design Life of Turbo Compressor Packages. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), January 1998. http://dx.doi.org/10.55274/r0010340.
The gas pipeline industry continues to respond to the challenges of competitive markets and the need to manage the cost of service effectively. A major cost element being reviewed by the industry is the operating and maintenance expense for its fleet of older turbo compressor units. Many turbo-machinery manufacturers and operators typically quote 100,000 hours as a design limit for service life of turbo compressor components. The Pipeline Research Committee initiated this study to review the life limiting criteria for certain critical components and determine if the design target of 100,000 hours can be safely and reliably met or extended with special component management practices. The first phase of the project was to select the turbomachinery components that would be included in the review. Committee members were surveyed with a detailed questionnaire designed to identify critical components based on: high hours (eg. at or approaching 100,000 hours), the most common engine types operated by the member organizations, and the components of greatest concern from a risk and expense point of view. The selection made covers a wide range of engine types that are of interest to most of the committee companies. This selection represents some 78% of the "high hour" units operated by the committee and includes components from GE Frame 3 and Frame 5, Solar Saturn, Rolls Royce Avon, and Cooper RT56 engines. The report goes into detail regarding the various damage mechanisms which can be the main life limiting factor of the component; creep, fatigue, environmental attack, wear and microstructure instability. For each of the component types selected, the study identifies the life limiting criteria and outlines how the components may be managed for extended life. Many of the selected components can be reliably operated beyond 100,000 hours by following the management practices set out in the report. The decision to continue to operate components or replace with new components is usually based on either a predetermined engineering life limit or retirement for cause. Operating life limits are based on engineering calculations that establish the component life, beyond which the risk of failure is high. Such limits assume a standard, or most often, a worst case set of operating conditions to be conservative for all types of service. Retirement for cause is based on specific inspection techniques applied at appropriate intervals to ensure that damage below a defined limit is identified and the parts are then removed for either refurbishment or retirement.
6
Al-Qadi, Imad, Hasan Ozer, Mouna Krami Senhaji, Qingwen Zhou, Rebekah Yang, Seunggu Kang, Marshall Thompson, et al. A Life-Cycle Methodology for Energy Use by In-Place Pavement Recycling Techniques. Illinois Center for Transportation, October 2020. http://dx.doi.org/10.36501/0197-9191/20-018.
Worldwide interest in using recycled materials in flexible pavements as an alternative to virgin materials has increased significantly over the past few decades. Therefore, recycling has been utilized in pavement maintenance and rehabilitation activities. Three types of in-place recycling technologies have been introduced since the late 70s: hot in-place recycling, cold in-place recycling, and full-depth reclamation. The main objectives of this project are to develop a framework and a life-cycle assessment (LCA) methodology to evaluate maintenance and rehabilitation treatments, specifically in-place recycling and conventional paving methods, and develop a LCA tool utilizing Visual Basic for Applications (VBA) to help local and state highway agencies evaluate environmental benefits and tradeoffs of in-place recycling techniques as compared to conventional rehabilitation methods at each life-cycle stage from the material extraction to the end of life. The ultimate outcome of this study is the development of a framework and a user-friendly LCA tool that assesses the environmental impact of a wide range of pavement treatments, including in-place recycling, conventional methods, and surface treatments. The developed tool provides pavement industry practitioners, consultants, and agencies the opportunity to complement their projects’ economic and social assessment with the environmental impacts quantification. In addition, the tool presents the main factors that impact produced emissions and energy consumed at every stage of the pavement life cycle due to treatments. The tool provides detailed information such as fuel usage analysis of in-place recycling based on field data.
7
Guirola, Luis, Laura Hospido, and Andrea Weber. Family and career: An analysis across Europe and North America. Madrid: Banco de España, May 2024. http://dx.doi.org/10.53479/36575.
Using data for 17 countries in Europe and North America, we compare the career trajectories of mothers and fathers and of women and men without children across cohorts and at different points in their life cycle. There is wide cross-country variation in employment and earnings gaps at age 30. At age 50, however, employment gaps between mothers and non-mothers have closed in most countries. We also observe convergence in employment gaps between mothers and fathers by age 50, but these gaps do not close altogether. Motherhood gaps in earnings also close by age 50 between mothers and non-mothers, particularly among the highly educated. But there is strong persistence in earnings gaps between mothers and fathers even among highly educated parents. The main reasons for the remaining gaps at later stages in the life-cycle are part-time work among women and fatherhood premia as fathers’ earnings outperform non-fathers’ over their life-cycle.
8
Cendales, Boris, Sergio Useche, Viviola Gómez, Leonor Cedillo, Daryl Stephenson, Shirly Yan, and Paul Landsbergis. Mental Health Outcomes among Urban Public Transport Workers: A Systematic Literature Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2023. http://dx.doi.org/10.37766/inplasy2023.1.0076.
Review question / Objective: Systematically review the literature to assess the effects of occupational exposures and interventions on Urban Public Transport (UTP) workers’ mental health. Condition being studied: In order to include a wide spectrum of outcomes, mental health was defined according to the WHO (2001) as a “state of well-being in which the individual realizes his or her own abilities, can cope with the normal stresses of life, can work productively and fruitfully, and is able to make a contribution to his or her community”.
9
Hammond. L52354 State of the Art Review - Development of Optimized Welding Solutions for X100 Line Pipe Steel. Chantilly, Virginia: Pipeline Research Council International, Inc. (PRCI), April 2012. http://dx.doi.org/10.55274/r0010637.
The driving force for the development of high strength steel for pipelines is the prospect of significant reduction in capital expenditure (CAPEX) in the construction and commissioning of long distance gas pipelines. Further savings might be made by design optimization and lower operating expenditure (OPEX) leading to enhanced whole life economics for such pipelines. Over the past 40 years, pipelines have been constructed in a wide range of steel grades specified in the well-known API Standard 5L ranging from grade A up to grade X80 (ISO 3183 Grade L555) and covering a range of specified minimum yield strength from 30 ksi (270 MPa) to 80 ksi (555 MPa). This work fully characterizes X100 prototype line pipe from four suppliers, to determine its weldability, to consider its influences on the design of pipelines together with design optimization and to determine its effects and implications on the construction of pipelines.
10
Ragunathan, Yoithapprabhunath Thuckanaickenpalayam, Srichinthu Kenniyan Kumar, Deepak Gupta, Diksha Singh, Swetha Pasupuleti, and Madhavan Nirmal Ramdas. Effectiveness of Neoadjuvant Molecular-Targeted Chemotherapy in Ameloblastoma - A Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2022. http://dx.doi.org/10.37766/inplasy2022.6.0018.
Review question / Objective: The aim of this article is to obtain an in-depth review of ameloblastoma tumor to determine the available level of evidence and the possible benefit of targeted therapeutics for the treatment of BRAF V600E mutation in ameloblastoma tumor. Condition being studied: Ameloblastoma is an epithelium-derived odontogenic tumour that evolved since the prehistoric era. Ameloblastoma is unique among the odontogenic neoplasms occurring in the jaws, because of its locally invasive behaviour and high recurrence rate. Facial asymmetry, displacement of teeth, malocclusion, and pathologic fractures are some of the asymmetrical features that ameloblastoma is known to cause. If left untreated, they often lead to wide tissue destruction and deformity. For the treatment of ameloblastomas, conventional chemotherapy and radiation have been unexplored or contraindicated and to date, wide surgical resection is the only treatment of choice for ameloblastoma tumours, resulting in post-treatment compromised quality of life in the individuals.
