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Dissertations / Theses on the topic 'Warfarin'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Zhang, Jieying Eunice. "Pharmacogenetics of warfarin." Thesis, University of Liverpool, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.569544.

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Warfarin is one of the most commonly used oral anticoagulants worldwide and is highly efficacious for the treatment and prevention of thromboembolic disorders. However, due to its narrow therapeutic index and large interindividual variability, it remains a challenging drug to prescribe. Genetic factors (CYP2C9 and VKORCI), together with clinical factors (age and body weight), account for up to 60% of warfarin dose variance but the remaining ~40% variability remains unexplained. A polymorphism rs2108622 in CYP4F2, a vitamin K oxidase, has previously been associated with increased warfarin stabl
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2

Ab, Ghani Azizah. "Pharmacogenetics in warfarin therapy." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/18317/.

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Warfarin is a challenging drug to dose accurately, especially during the initiation phase because of its narrow therapeutic range and large inter-individual variability. Therefore, the aim of this thesis was to investigate the use of pharmacogenetics and clinical data to improve warfarin therapy. Genetic variants in cytochrome P450 2C9 (CYP2C9) and vitamin K epoxide reductase (VKORC1) are known to influence warfarin dose. Therefore we developed a pharmacogenetic dosing algorithm to predict warfarin stable dose prospectively in a British population based on 456 patients who started warfarin in
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3

Choiniere, Jennifer. "Content and Uniformity of Mexican Manufactured Lovastatin and Warfarin Versus American Manufactured Lovastatin and Warfarin." The University of Arizona, 2005. http://hdl.handle.net/10150/624720.

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Class of 2005 Abstract<br>Objective: To analyze the quantity of active ingredient as well as the content uniformity of lovastatin and warfarin manufactured in Mexico as compared to the lovastatin and warfarin manufactured in the United States. Methods: High-pressure liquid chromatography assays modified from the U.S. Pharmacopoeia will be used to evaluate the amount of active ingredient found in lovastatin and warfarin manufactured in Mexico and America. Area-under-the-curve analysis was done to evaluate relative quantities of the active ingredients. Results: The amount of lovastatin found i
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4

Ghaswalla, Parinaz K. "Medication-Related Problems in Older Adults: A Focus on Underuse of Warfarin and Warfarin-Antibiotic Interactions." VCU Scholars Compass, 2011. http://scholarscompass.vcu.edu/etd/2631.

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The work presented in this dissertation focuses on two important medication-related problems in older adults, that is, untreated indication and drug-drug interactions, specifically with respect to a high-risk medication such as warfarin. Warfarin is a challenge to use in clinical practice due to its narrow therapeutic index, variability in dose-response and its interactions with numerous foods and drugs. This dissertation presents the research from two projects. In the first project the prevalence and predictors of warfarin use in nursing home (NH) residents with atrial fibrillation (AF), and
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5

Eriksson, Niclas. "On the Prediction of Warfarin Dose." Doctoral thesis, Uppsala universitet, Klinisk farmakologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-172864.

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Warfarin is one of the most widely used anticoagulants in the world. Treatment is complicated by a large inter-individual variation in the dose needed to reach adequate levels of anticoagulation i.e. INR 2.0 – 3.0. The objective of this thesis was to evaluate which factors, mainly genetic but also non-genetic, that affect the response to warfarin in terms of required maintenance dose, efficacy and safety with special focus on warfarin dose prediction. Through candidate gene and genome-wide studies, we have shown that the genes CYP2C9 and VKORC1 are the major determinants of warfarin maintenanc
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6

Chen, Y. Y. "Genetics of the anticoagulant drug warfarin." Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597528.

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In this thesis I use the most widely prescribed anticoagulant drug, warfarin, as a model to investigate the effect of genetic determinants on drug efficacy and safety. Following a literature review of all the genes involved in warfarin pharmacokinetics and pharmacodynamics, 35 candidate genes were selected for investigation. Two independent Swedish cohorts of warfarin-treated patients were analysed. First linkage disequilibrium maps were constructed for each gene. Selected SNPs integrated with putative functional variants were genotyped in 201 patients recruited at the Uppsala University. A pa
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7

Khan, Tayyaba Irfan. "Factors affecting anticoagulation response to Warfarin." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413389.

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8

Myszka, David Gerard. "Photoaffinity labeling of warfarin binding proteins /." The Ohio State University, 1991. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487694702785693.

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9

Msolli, Ines. "Nanosystèmes polymères pour la libération contrôlé de la Warfarine : conception et évaluation biologique." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCD033/document.

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Dans ce travail de thèse, nous avons synthétisé des dérivés de poly(acide (R,S)-3,3-diméthylmalique) (PDMMLA). Les copolymères de PDMMLA sont composésprincipalement de deux monomères: un monomère hydrophobe contenant un groupementhexylique et un monomère hydrophile contenant un groupement acide. Grâce à la proportionde chaque monomère dans le copolymère final, la balance hydrophile/hydrophobe est ajustée.Donc six copolymères ont été obtenus: trois copolymères statistiques PDMMLAHn-co-Hex100-n et trois copolymères à blocs PDMMLAHn-b-Hex100-n. Ces copolymères sont àl’origine de nanoparticules sa
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10

Hickmott, Helen Ruth. "Factors affecting the pharmacological activity of warfarin." Thesis, University of Newcastle Upon Tyne, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.251170.

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11

Chan, E. W.-Y. "Warfarin : Stereochemical aspects of pharmacokinetics and response." Thesis, University of Manchester, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374525.

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12

Choonara, I. A. "Clinical pharmacology of warfarin and vitamin K." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383440.

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13

Misra, Devyani. "Warfarin use and risk of osteoporotic fractures." Thesis, Boston University, 2012. https://hdl.handle.net/2144/21219.

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Thesis (M.S.M.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>OBJECTIVE: Prior studies examining the association of warfarin use and osteoporotic fractures have found conflicting results and have had methodological problems, such as confounding by indication and confounding by duration of w
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14

Russomanno, Giusy. "Translational pharmacogenomics: a study of warfarin dosing." Doctoral thesis, Universita degli studi di Salerno, 2016. http://hdl.handle.net/10556/2210.

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2014 - 2015<br>Warfarin is one of the most commonly used oral anticoagulants worldwide and is highly efficacious for the treatment and prevention of thromboembolic disorders. However, due to its narrow therapeutic index, large inter-individual variability in dose requirements, and extensive drug and food interactions, warfarin remains a challenging drug to prescribe. Genetic factors (CYP2C9 and VKORC1), together with clinical factors (age and body weight), account for up to 60% of warfarin dose variance, whereas ~40% variability remains poorly understood. Several warfarin dosing algorithms, c
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15

Dahlgren, Marie, and Anneli Johansson. "Warfarinbehandlade patienters behov av information." Thesis, Halmstad University, School of Social and Health Sciences (HOS), 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-2956.

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<p>Ett stort antal patienter behandlas med warfarin som förebyggande mot blodpropp. Läkemedlet kräver regelbunden blodprovstagning där INR- värdet mäts för att kunna anpassa dosen individuellt så länge behandling pågår. Indikationen kan till exempel vara förmaksflimmer, mekanisk hjärtklaff eller tromboembolism. Warfarin är ett känt problemläkemedel där interaktionsrisken med andra läkemedel är stor och andra faktorer såsom kost och livsstilsförändringar kan påverka dess effekt. Syftet med litteraturstudien var att beskriva patienters behov av information vid warfarinbehandling. Studien baseras
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16

King, Barry Philip. "Genetic factors affecting warfarin dose requirements and clearance." Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.417716.

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17

Liaghat, Mitra. "Sjuksköterskors erfarenheter och upplevelser av att arbeta inom antikoagulationsmottagning." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-219561.

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Background Number of patients treated with medicine that has an anticoagulation character is constantly increasing. Chronic atrial fibrillation is the most common diagnosis being treated, but other diagnoses such as venous thrombosis), pulmonary embolism, stroke, coronary stent thrombosis and arterial thrombosis treated. There are a variety of anticoagulant drugs. In Sweden Warfarin is used as standard medicine for oral anticoagulation therapy. Purpose The purpose of this study is to examine and reflect nurses' experiences of working on anticoagulation clinic, and if he / she claims to have ac
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18

Mullan, Judy. "To develop and trial a new warfarin education program." Access electronically, 2005. http://www.library.uow.edu.au/adt-NWU/public/adt-NWU20060221.101350/index.html.

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Thesis (Ph.D.)--University of Wollongong, 2005.<br>Typescript. This thesis is subject to a two year embargo until 17/11/2007 and may only be viewed and copied with the permission of the author. For further information please Contact the Archivist. Includes bibliographical references: leaf 226-249.
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19

Shaw, Kaitlyn. "The pharmacogenomics of warfarin safety and effectiveness in children." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44242.

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20

Leksell, Sofia. "Är NOAK ett bättre behandlingsalternativ än warfarin vid förmaksflimmer?" Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-53851.

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Bakgrund Förmaksflimmer är en arytmi som uppkommer av att sinusknutan slutar styra hjärtrytmen och impulser initieras istället på flera olika ställen i förmaken. Detta orsakar en snabb och oregelbunden kontraktion med försämrad cirkulation som resultat. Förmaksflimmer är den vanligaste orsaken till stroke och en viktig del i behandlingen av förmaksflimmer är därför att förebygga stroke genom antikoagulerande läkemedel. Warfarin har länge varit förstahandsval, men nya läkemedel, så kallade icke vitamin K antagonist oral antikoagulantia (NOAK) har de senaste åren godkänts som förebyggande behand
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21

Clark, Justin. "An evaluation of Warfarin and Statin Drug-Drug Interactions." The University of Arizona, 2012. http://hdl.handle.net/10150/623593.

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Class of 2012 Abstract<br>Objectives: To evaluate the literature with respect to drug-drug interactions of the hydroxymethylglutaryl CoA reductase inhibitors atorvastatin, fluvastatin, lovastatin, pitavastitin, pravastatin, simvastatin, and rosuvastatin with warfarin. Methods: This descriptive retrospective study identified articles reporting on each drug-drug interaction from the online databases PubMed (1970 – February 2012) and the drug compendia Micromedex and Facts & Comparisons. The studies included in this investigation were primary literature reports, written in English with human sub
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22

Clark, Justin, and Daniel Malone. "An Evaluation of Warfarin and Statin Drug-Drug Interactions." The University of Arizona, 2012. http://hdl.handle.net/10150/614476.

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Class of 2012 Abstract<br>Objectives: To evaluate the literature with respect to drug-drug interactions of the hydroxymethylglutaryl CoA reductase inhibitors atorvastatin, fluvastatin, lovastatin, pitavastitin, pravastatin, simvastatin, and rosuvastatin with warfarin. Methods: This descriptive retrospective study identified articles reporting on each drug-drug interaction from the online databases PubMed (1970 – February 2012) and the drug compendia Micromedex and Facts & Comparisons. The studies included in this investigation were primary literature reports, written in English with human
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23

Smith, Nicole Thomas. "Validation of criteria used to predict warfarin dosing decisions /." Diss., CLICK HERE for online access, 2004. http://contentdm.lib.byu.edu/ETD/image/etd427.pdf.

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24

Thomas, Nicole. "Validation of Criteria Used to Predict Warfarin Dosing Decisions." BYU ScholarsArchive, 2004. https://scholarsarchive.byu.edu/etd/40.

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People at risk for blood clots are often treated with anticoagulants, warfarin is such an anticoagulant. The dose's effect is measured by comparing the time for blood to clot to a control time called an INR value. Previous anticoagulant studies have addressed agreement between fingerstick (POC) devices and the standard laboratory, however these studies rely on mathematical formulas as criteria for clinical evaluations, i.e. clinical evaluation vs. precision and bias. Fourteen such criteria were found in the literature. There exists little consistency among these criteria for assessing clinical
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25

Gilbert, Kimberlee Danielle. "Interactions between herbal supplements and warfarin: a patient teaching tool." Montana State University, 2012. http://etd.lib.montana.edu/etd/2012/gilbert/GilbertK0512.pdf.

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Many Americans are using herbal supplements without telling their primary care providers. When a person is taking warfarin, a medication that has a narrow therapeutic window and the potential for interaction with many substances, including food, medications, and supplements, providers must inform them of the risks. A literature review was done to find current literature related to warfarin and herbal interactions. Limited quality data is available, with most literature found being case reports, and small population studies. A patient teaching pamphlet was created and tested using a pre-test/po
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26

Hamberg, Anna-Karin. "Pharmacometric Models for Individualisation of Warfarin in Adults and Children." Doctoral thesis, Uppsala universitet, Klinisk farmakogenomik och osteoporos, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-197599.

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Warfarin is one of the most widely used anticoagulants. Therapy is complicated by warfarin’s narrow therapeutic range and pronounced variability in individual dose requirements. Although warfarin therapy is uncommon in children, it is crucial for children with certain congenital or acquired heart diseases. Treatment in children is especially difficult due to the lack of i) a decision support tool for efficient and consistent dose adjustments, and ii) a flexible warfarin formulation for accurate and reproducible dosing. The overall aim of this thesis was to develop a PKPD-based pharmacometric m
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27

Sconce, Elizabeth A. "Improving the stability of anticoagulation in patients on warfarin therapy." Thesis, University of Newcastle Upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437259.

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28

Sandén, Per. "Efficacy and safety of warfarin treatment in venous thromboembolic disease." Doctoral thesis, Umeå universitet, Institutionen för folkhälsa och klinisk medicin, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-133618.

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Background As a major cause of morbidity and mortality treatment of venous thromboembolism is important, with the correct use of anticoagulants it is possible to greatly reduce both mortality and morbidity. Warfarin is among the most widely used anticoagulants being effective in treatment and prevention of venous thromboembolism with few negative side effects other than bleeding complications. With a narrow therapeutic window warfarin treatment requires constant monitoring and adjustments to stay effective without an increased bleeding risk. The aim of this thesis was to study the efficacy and
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29

Pisa, Ana Carolina Chaves. "Efeito do controle de morcegos Desmodus rotundus na ocorrência de focos de raiva no estado do Espírito Santo." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-25082015-102004/.

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A raiva é uma zoonose nervosa, aguda e fatal que acomete todos os mamíferos e provoca enormes prejuízos para os pecuaristas. No ciclo epidemiológico rural, a doença é transmitida por morcegos hematófagos aos herbívoros e, ainda que haja um esforço por parte dos órgãos de defesa e dos produtores rurais para que se evite a ocorrência da doença, historicamente percebe-se que o combate à raiva com base somente na atuação em focos e vacinação de suscetíveis não elimina eficazmente o problema. Um dos pilares do Programa Nacional de Controle da Raiva dos Herbívoros (PNCRH) do Ministério da Agricultur
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30

Osman, Abdimajid. "Studies on warfarin treatment with emphasis on inter-individual variations and drug monitoring." Doctoral thesis, Linköping : Linköping University, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1000s.pdf.

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31

Delaney, Joseph Austin C. "Assessing the risks associated with warfarin therapy and related methodological considerations." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19281.

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Warfarin is an anticoagulant medication that is used for the prevention and treatment of venous and arterial thrombotic complications. The evaluation of the risks associated with warfarin therapy, and its interaction with other drugs, poses important methodological challenges. In this thesis, we studied two of these risks and assessed techniques to address these methodological challenges using data from the United Kingdom's General Practice Research Database (GPRD). First, we conducted a case-control study to examine the r
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32

Biss, Tina Tracey. "Identification of the factors influencing anticoagulation response to warfarin in children." Thesis, University of Newcastle Upon Tyne, 2012. http://hdl.handle.net/10443/1546.

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The requirement for anticoagulant therapy in children is increasing and warfarin remains the long-term anticoagulant agent of choice. However, little is known about the factors that influence inter-individual variability in response to warfarin among children. The aim of this MD was to gain a greater understanding of the factors that affect warfarin anticoagulant control and response in children. A retrospective study of a cohort of anticoagulated children identified factors contributing to poor anticoagulant control. It also highlighted the importance of the way in which anticoagulant control
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33

Hatch, Ellen. "Variability in response to warfarin : analysis of pharmacogenetic and environmental factors." Thesis, University of Newcastle Upon Tyne, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.500980.

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Anticoagulation response to warfarin is unpredictable because of the wide interindividual variability in dose requirement and the drug's narrow therapeutic index. The aim of my PhD project was to ftirther investigate and identify factors that contribute to the variability in warfarin dose requirements. Identification of the factors contributing to the variability could help toward improving the safety of warfarin through personalized therapy.
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34

Jorgensen, Andrea Lyn. "Improving the evidence base in pharmacogenetic studies : Warfarin as an example." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539496.

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35

Al-Zubiedi, Sameh A. "Investigating warfarin variabilty : the contribution of clinical, genetic, and enviromental factors." Thesis, University of Liverpool, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501741.

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Warfarin is the most widely used oral anticoagulant for the prevention and treatment of various cardiovascular diseases. However, its complications represent an important clinical problem. The drug has a very low therapeutic index and there is significant interpatient and inter-iscmer variability in both pharmacokinetics and pharmacodynamics; these are affected by a large number of genetic and non-genetic factors. Genetic variation in CYP2C9 and VKORCl has been most extensively studied in relation to warfarin dose requirements.
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36

Barraclough, John. "Pharmacogenetic, clinical and demographic factors in the management of warfarin therapy." Thesis, Sheffield Hallam University, 2012. http://shura.shu.ac.uk/20622/.

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It has been estimated that, at any one time, more than one million people in the U.K. are taking the anticoagulant drug warfarin, for the treatment or prevention of venous thromboembolism. The incidence of life threatening haemorrhage, due to overdose, is approximately two per one hundred patient years. It is well known that there is great inter-individual variability in reaching and maintaining a therapeutic level of oral anticoagulants, in part, due to the combined effect of gender, age, body size and drug interactions. In recent years, single nucleotide polymorphisms (SNPs) have been identi
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37

Sutcliffe, Frances Anne. "Warfarin metabolism and disposition in anticoagulant-resistant and susceptible mouse strains." Thesis, University of Surrey, 1986. http://epubs.surrey.ac.uk/848073/.

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The differential susceptibilities of warfarin-susceptible LAC-grey and warfarin-resistant HC house mice to the anticoagulant effect of the oral rodenticide 3-(alpha-acetonyl benzyl)-4-hydroxycoumarin (Warfarin) in terms of their blood clotting times, were determined. The hypoprothrombinaemic effect of both the R(+) and S(-) warfarin enantiomers was also investigated, in addition to the standard test for warfarin-resistance in mice, the ability to survive on a diet containing 0.025% warfarin for 21 days. Onto this base of knowledge of the exact hypoprothrombinaemic responses evoked by treatment
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38

Podda, G. "PREDICTION OF OPTIMAL WARFARIN MAINTENANCE DOSE USING ADVANCED ARTIFICIAL NEURAL NETWORKS." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/219087.

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Introduction. The individual response to vitamin K antagonists (VKA) is highly variable, being influenced by clinical factors and genetic variants of enzymes that are involved in the metabolism of VKA (CYP2C)) and vitamin K (VKORC1). Currently, the dose of VKA is adjusted based on measurements of the prothrombin time. In the last years, mathematical algorithms were developed for estimating the appropriate VKA dose, based on different mathematical approaches working on clinical and genetic data. Artificial Neural Networks (ANN) are computerized algorithms resembling interactive processes of th
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39

Ho, Lok-yan. "The clinical efficacy and risk of anticoagulation in Chinese patients /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B3829591X.

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40

Cholerton, S. "A study of the relationships between the pharmacokinetics and the pharmacodynamics of warfarin and vitamin K1̲." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381337.

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41

Chemodurow, Lucy, and Shanna Christensen. "A Pre-­‐ Post-­‐Evaluation of Implementing an Inpatient Warfarin Monitoring and Education Policy." The University of Arizona, 2010. http://hdl.handle.net/10150/623797.

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Class of 2010 Abstract<br>OBJECTIVES: The objective of this study was to evaluate whether implementation of new anticoagulation policy at a community hospital resulted in better monitoring of warfarin, increased warfarin patient education prior to discharge, and less bleeding complications due to warfarin. METHODS: This study was a pre-­‐ post-­‐retrospective chart review quality improvement study. A retrospective chart review was conducted of all patients who were inpatients and received warfarin in the time period of April 1, 2008 to July 31, 2008 (historical control group before implemen
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42

Hellman, Jacob, and Jonny Dahlberg. "Development of an applicationfor individualized Warfarin treatment : Independent Project in Engineering Physics." Thesis, Uppsala universitet, Institutionen för teknikvetenskaper, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-180358.

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A problem with the widley usedanticoagulant medicine Warfarin hasalways been that the therapeutic dosevaries from person to person and thatthere has not been any methods toestimate individually-based dosingregimens. By using a new populationmodeldescribing the relationship betweenWarfarin dose and INR(internationalnormalized ratio) response fordifferent individuals based on their age,weight and genotypes, a user friendly,dose estimating program has beendeveloped in Java. The applicationestimates the INR given the individualparameters and dosing, but it's alsopossible to estimate the predicted
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43

Coleman, Craig I., Jan Beyer-Westendorf, Thomas J. Bunz, Charles E. Mahan, and Alex C. Spyropoulos. "Postthrombotic Syndrome in Patients Treated With Rivaroxaban or Warfarin for Venous Thromboembolism." Sage, 2018. https://tud.qucosa.de/id/qucosa%3A35470.

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Postthrombotic syndrome (PTS) is a frequent complication of venous thromboembolism (VTE). Using MarketScan claims data from January 2012 to June 2015, we identified adults with a primary diagnosis code for VTE during a hospitalization/emergency department visit, ≥6 months of insurance coverage prior to the index event and newly started on rivaroxaban or warfarin within 30 days of the index VTE. Patients with <4-month follow-up postindex event or a claim for any anticoagulant during 6-month baseline period were excluded. Differences in baseline characteristics between rivaroxaban and warfarin u
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44

Kidd, Robert Scott. "The Development And Validation Of A Novel Genetic-Based Warfarin Dosing Nomogram." The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1216306028.

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45

Mosher, Carrie M. "CYP2C9 binding determinants and activation mechanisms for phenytoin and (S)-warfarin metabolism /." Thesis, Connect to this title online; UW restricted, 2008. http://hdl.handle.net/1773/8170.

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46

Hermans, Johannes Jozef Robertus Maria. "Comparative metabolism of warfarin and acenocoumarol: stereoselectivity in oxidative and reductive biotransformation routes." [Maastricht : Maastricht : Rijksuniversiteit Limburg] ; University Library, Maastricht University [Host], 1993. http://arno.unimaas.nl/show.cgi?fid=6508.

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47

Perona, Stephen. "Hemorrhagic Events Lead to an Increase in International Normalized Ratio in Warfarin Patients." The University of Arizona, 2010. http://hdl.handle.net/10150/623790.

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Class of 2010 Abstract<br>OBJECTIVES: The purpose of this study was to demonstrate that an increase in INR is associated with a hemorrhagic event in patients taking the oral anticoagulant warfarin. METHODS: A retrospective review of data from 18 patients previously stable on warfarin therapy with an elevation in INR at the time of a hemorrhagic event. Patients were receiving warfarin treatment in the anticoagulation clinic at the Southern Arizona VA Healthcare system from April 2008 to December 2009. Primary outcome measures included a comparison of INR, warfarin dose, and hematocrit at basel
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Hood, Evan, and Jeannie K. Lee. "Postoperative Warfarin Re-Initiation Strategies: an Interview-Based Comparison of Certified Anticoagulation Providers." The University of Arizona, 2013. http://hdl.handle.net/10150/614249.

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Class of 2013 Abstract<br>Specific Aims: The purpose of this study is to identify a postoperative warfarin re-initiation protocol used most commonly by certified anticoagulation providers. Our main hypothesis is that certified Anticoagulation providers use a postoperative warfarin re-initiation strategy based upon clinical experience/knowledge as opposed to a guideline-based approach. Methods: The Anticoagulation Forum website will be used to select the anticoagulation providers to interview via telephone. The selection process will be as follows: an excel spreadsheet will be created separa
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Cove, Christina Lauren. "Severe renal dysfunction among individuals taking warfarin and implications for new oral anticoagulants." Thesis, Boston University, 2014. https://hdl.handle.net/2144/21140.

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Thesis (M.S.M.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>BACKGROUND: Although novel anticoagulant drugs have proven safety and efficacy profiles from Phase III clinical trials, those patients with significant kidney disease were excluded. The lack of knowledge about incidence, severity
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50

Lind, Marcus. "Determinants of adverse events during oral anticoagulant treatment." Doctoral thesis, Umeå universitet, Institutionen för folkhälsa och klinisk medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-53431.

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Treament with oral anticoagulation is highly effective in reducing the burden of thromboembolic complications in several clinical conditions. The number of patients receiving oral anticoagulation is growing steadily. InSwedenabout 1.5 percent of the population receives treatment. Although the treatment is highly effective in preventing thromboembolic complications, it is also associated with a substantial increase in the risk of bleeding. In clinical practice every physician has to balance the potential benefit of treatment against the risk of bleeding complications in the individual patient.
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