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Трегуб, П. П., Н. А. Малиновская, В. П. Куликов, and Д. А. Кузовков. "Hypercapnia and its combination with hypoxia decrease the permeability of the blood-brain barrier in rats." Zhurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», no. 2 (June 28, 2021): 30–36. http://dx.doi.org/10.25557/0031-2991.2021.02.30-36.
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Цель исследования - оценка проницаемости ГЭБ после сочетанного воздействия гиперкапнии и гипоксии. Методика. Исследования проведены на 40 крысах-самцах Wistar рандомизированых на 4 равные группы (n=10): нормобарическая гипоксия (PO2 - 90 мм рт. ст./13%; PCO2 - 1 мм рт. ст./0,1%); пермиссивная гиперкапния (PO2 - 150 мм рт. ст./21%; PСO2 - 50 мм рт. ст./7%); гиперкапническая гипоксия (PO2 - 90 мм рт. ст./13%; PCO2 - 50 мм рт. ст./7%); контрольная группа (PO2 - 150 мм рт. ст./21%; PCO2 - 1 мм рт. ст./0,1%). Респираторные воздействия проводили в специальной камере в течение 15 сут по 30 мин ежедневно. Газовую смесь подавали в камеру компрессором со скоростью 15 л/мин. Контроль газового состава в камере проводили газоанализатором Microlux (Микролюкс, Россия). Через 24 ч после завершения курсов респираторных воздействий животным внутрибрюшинно вводили 2%-й раствор красителя Evans blue в объеме 4 мл/кг массы животного. Оценку проницаемости ГЭБ осуществляли через 24 ч после введения красителя путем фотометрического измерения его содержания в плазме крови и флуоресцентной микроскопии ткани головного мозга. Анализ интенсивности флуоресценции Evans blue в ткани головного мозга проводился на конфокальном микроскопе FV10i-W (Olympus, Япония). Определяли флуоресцентную интегративную оптическую плотность Evans blue с последующим расчетом индекса проницаемости по концентрации красителя в крови. Определение содержания красителя в крови осуществляли фотометрически (при 610 нм) с использованием планшетного фотометра Multiscan FS (Thermo scientific, США) по калибровочным кривым. Результаты. Индекс проницаемости ГЭБ (содержание в мозге/концентрация в крови) был существенно ниже в группах, которые подвергались респираторным воздействиям с наличием гиперкапнического компонента. Заключение. Интермиттирующая гиперкапническая гипоксия формирует наименьший уровень проницаемости ГЭБ по сравнению с изолированным воздействием гипоксии или гиперкапнии. The aim of study was to evaluate the blood-brain barrier (BBB) permeability after a combined treatment with hypercapnia and hypoxia. Methods. Experiments were performed on 40 Wistar male rats randomized to 4 equal groups (n=10): normobaric hypoxia (PO2 = 90 mm Hg/13%/PCO2 = 1 mm Hg/0.1% CO2,), permissive hypercapnia (PO2 = 150 mm Hg/21%; PCO2 = 50 mm Hg/7%); hypercapnic hypoxia (PO2 = 90 mm Hg/13%, PCO2 = 50 mm Hg/7%); and a control group (PO2 - 150 mm Hg/21%; PCO2 - 1 mm Hg/0.1%) in a special chamber for 15 days, 30 min daily. The gas mixture was delivered to the chamber with a compressor at 15 l/min. Gas composition was monitored with a gas analyzer (Microlux, Russia). At 24 hrs after completion of respiratory exposures, Evans blue dye was administered i.p. (4 ml/kg body weight). BBB permeability was assessed from the content of Evans blue dye in blood plasma photometrically and in brain tissue by fluorescent microscopy. Evans blue fluorescence intensity in brain tissue was analyzed with a confocal microscope FV10i-W (Olympus, Japan). Fluorescent integrative optical density of Evans blue was determined and used for calculation of the permeability index from blood concentration of the dye. Blood concentration of the dye was measured photometrically (at 610 nm) with a plate photometer Multiscan FS (Thermo Scientific, USA) using calibration curves. Results. The BBB permeability index (content of Evans blue dye in the brain / concentration of Evans blue dye in blood) was significantly lower in the groups that underwent respiratory exposures with the presence of a hypercapnic component. Conclusion. Intermittent hypercapnic hypoxia yields the lowest BBB permeability compared to the isolated effect of either hypoxia or hypercapnia.
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Kłosińska, Urszula. "Ocena obiektów cebuli (Allium cepa L.) pod względem tolerancji na suszę w fazie kiełkowania i wzrostu siewek." Biuletyn Instytutu Hodowli i Aklimatyzacji Roślin, no. 291 (December 9, 2020): 93–99. http://dx.doi.org/10.37317/biul-2020-pb89.
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Celem badań była ocena wpływu niedoboru wody na zdolność kiełkowania nasion i wzrost siewek cebuli oraz identyfikacja obiecujących obiektów do wykorzystania w przyszłych programach hodowli nowych odmian cebuli tolerancyjnych na stres suszy. Oceniono 150 linii/odmian cebuli pochodzących z polskich i zagranicznych firm hodowlano-nasiennych oraz z Banku Genów Instytutu Ogrodnictwa w Skierniewicach. Doświadczenia prowadzono w warunkach laboratoryjnych indukując stres suszy przez zastosowanie 18% poliglikolu etylenowego (PEG8000) w fazie kiełkowania nasion i 10% PEG w fazie siewek. Badane obiekty cebuli wykazały istotne zróżnicowanie pod względem tolerancji na stres suszy, potwierdzone wysokimi wartościami współczynnika zmienności (CV) dla ocenianych parametrów: maksymalny procent skiełkowanych nasion (35,3%), świeża masa siewek (38,5%), długość liścieni siewek (42,9%) i długość korzeni siewek (56,3%). Zanotowano, że niedobór wody najmniej ograniczył kiełkowanie nasion o 23%, następnie długość korzeni o 36%, a najbardziej świeżą masę siewek i długość liścieni, odpowiednio o 52% i 53,5%. Stwierdzono silną korelację (r = 0,81‒0,86) między cechami opisującymi wzrost siewek w warunkach suszy, wskazując, że deficyt wody redukuje wzrost całych siewek. Natomiast zależności pomiędzy nimi a kiełkowaniem w stresie suszy okazały się nieistotne (r = 0,19‒0,24). Spośród 150 obiektów cebuli, genotyp 171026 wykazał wysoki poziom tolerancji na suszę zarówno w fazie kiełkowania, jak i w fazie siewek.
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KITLV, Redactie. "Book reviews." New West Indian Guide / Nieuwe West-Indische Gids 86, no. 3-4 (January 1, 2012): 309–407. http://dx.doi.org/10.1163/13822373-90002420.
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A World Among these Islands: Essays on Literature, Race, and National Identity in Antillean America, by Roberto Márquez (reviewed by Peter Hulme) Caribbean Reasonings: The Thought of New World, The Quest for Decolonisation, edited by Brian Meeks & Norman Girvan (reviewed by Cary Fraser) Elusive Origins: The Enlightenment in the Modern Caribbean Historical Imagination, by Paul B. Miller (reviewed by Kerstin Oloff) Caribbean Perspectives on Modernity: Returning Medusa’s Gaze, by Maria Cristina Fumagalli (reviewed by Maureen Shay) Who Abolished Slavery: Slave Revolts and Abolitionism: A Debate with João Pedro Marques, edited by Seymour Drescher & Pieter C. Emmer, and Abolitionism and Imperialism in Britain, Africa, and the Atlantic, edited by Derek R . Peterson (reviewed by Claudius Fergus) The Mediterranean Apprenticeship of British Slavery, by Gustav Ungerer (reviewed by James Walvin) Children in Slavery through the Ages, edited by Gwyn Campbell, Suzanne Miers & Joseph C. Miller (reviewed by Indrani Chatterjee) The Invisible Hook: The Hidden Economics of Pirates, by Peter T. Leeson (reviewed by Kris Lane) Theorizing a Colonial Caribbean-Atlantic Imaginary: Sugar and Obeah, by Keith Sandiford (reviewed by Elaine Savory) Created in the West Indies: Caribbean Perspectives on V.S. Naipaul, edited by Jennifer Rahim & Barbara Lalla (reviewed by Supriya M. Nair) Thiefing Sugar: Eroticism between Women in Caribbean Literature, by Omise’eke Natasha Tinsley (reviewed by Lyndon K. Gill) Haiti Unbound: A Spiralist Challenge to the Postcolonial Canon, by Kaiama L. Glover (reviewed by Asselin Charles) Divergent Dictions: Contemporary Dominican Literature, by Néstor E. Rodríguez (reviewed by Dawn F. Stinchcomb) The Caribbean Short Story: Critical Perspectives, edited by Lucy Evans, Mark McWatt & Emma Smith (reviewed by Leah Rosenberg) Society of the Dead: Quita Manaquita and Palo Praise in Cuba, by Todd Ramón Ochoa (reviewed by Brian Brazeal) El Lector: A History of the Cigar Factory Reader, by Araceli Tinajero (reviewed by Juan José Baldrich) Blazing Cane: Sugar Communities, Class, and State Formation in Cuba, 1868-1959, by Gillian McGillivray (reviewed by Consuelo Naranjo Orovio) The Purposes of Paradise: U.S. Tourism and Empire in Cuba and Hawai’i, by Christine Skwiot (reviewed by Amalia L. Cabezas) A History of the Cuban Revolution, by Aviva Chomsky (reviewed by Michelle Chase) The Cubalogues: Beat Writers in Revolutionary Havana, by Todd F. Tietchen (reviewed by Stephen Fay) The Devil in the Details: Cuban Antislavery Narrative in the Postmodern Age, by Claudette M. Williams (reviewed by Gera Burton) Screening Cuba: Film Criticism as Political Performance during the Cold War, by Hector Amaya (reviewed by Ann Marie Stock) Perceptions of Cuba: Canadian and American Policies in Comparative Perspective, by Lana Wylie (reviewed by Julia Sagebien) Forging Diaspora: Afro-Cubans and African Americans in a World of Empire and Jim Crow, by Frank Andre Guridy (reviewed by Susan Greenbaum) The Irish in the Atlantic World, edited by David T. Gleeson (reviewed by Donald Harman Akenson) The Chinese in Latin America and the Caribbean, edited by Walton Look Lai & Tan Chee-Beng (reviewed by John Kuo Wei Tchen) The Island of One People: An Account of the History of the Jews of Jamaica, by Marilyn Delevante & Anthony Alberga (reviewed by Barry Stiefel) Creole Jews: Negotiating Community in Colonial Suriname, by Wieke Vink (reviewed by Aviva Ben-Ur) Only West Indians: Creole Nationalism in the British West Indies, by F.S.J. Ledgister (reviewed by Jerome Teelucksingh) Cultural DNA: Gender at the Root of Everyday Life in Rural Jamaica, by Diana J. Fox (reviewed by Jean Besson) Women in Grenadian History, 1783-1983, by Nicole Laurine Phillip (reviewed by Bernard Moitt) British-Controlled Trinidad and Venezuela: A History of Economic Interests and Subversions, 1830-1962, by Kelvin Singh (reviewed by Stephen G. Rabe) Export/Import Trends and Economic Development in Trinidad, 1919-1939, by Doddridge H.N. Alleyne (reviewed by Rita Pemberton) Post-Colonial Trinidad: An Ethnographic Journal, by Colin Clarke & Gillian Clarke (reviewed by Patricia van Leeuwaarde Moonsammy) Poverty in Haiti: Essays on Underdevelopment and Post Disaster Prospects, by Mats Lundahl (reviewed by Robert Fatton Jr.) From Douglass to Duvalier: U.S. African Americans, Haiti, and Pan Americanism, 1870-1964, by Millery Polyné (reviewed by Brenda Gayle Plummer) Haiti Rising: Haitian History, Culture and the Earthquake of 2010, edited by Martin Munro (reviewed by Jonna Knappenberger) Faith Makes Us Live: Surviving and Thriving in the Haitian Diaspora, by Margarita A. Mooney (reviewed by Rose-Marie Chierici) This Spot of Ground: Spiritual Baptists in Toronto, by Carol B. Duncan (reviewed by James Houk) Interroger les morts: Essai sur le dynamique politique des Noirs marrons ndjuka du Surinam et de la Guyane, by Jean-Yves Parris (reviewed by H.U.E. Thoden van Velzen & W. van Wetering)
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Horton, B. D. "Ripening Patterns within a Peach as Indicated by Force and Soluble Solids Concentration." Journal of the American Society for Horticultural Science 117, no. 5 (September 1992): 784–87. http://dx.doi.org/10.21273/jashs.117.5.784.
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Variability in maturity within a peach (Prunus persica, L. Batsch) fruit was estimated by measurements of force and the soluble solids concentration (SSC) at 16 coordinates around the peach at five maturity stages: 1) about one-half final swell (immature); 2) 85% final swell (green); 3) firm-ripe and similar to chip #3 of the Clemson Univ. system; 4) firm-ripe and similar to chip #5; and 5) tree-ripe. Firm-ripe 3 and 4 stages were firm enough to ship, but the tree-ripe stage was too soft. Firmness measured with a 4.7-mm-diameter penetrometer tip from two cultivars indicates a strong trend for the peach tip and cheeks to be firmer than tissue at other coordinates. Coordinates at the equator and around the stem end are generally firmer than coordinates at lat. 45°N, particularly in stages 3, 4, and 5. The SSC in juice from a cylinder of fruit adjacent to the puncture was higher at long. 90°E-W than at the sutures and higher at lat. 0° than at 70°S. Variance increased for force and decreased for SSC between maturity stages to the firm-ripe stage. The coordinate technique might be used to characterize and select cultivars that would be most suitable for once-over harvests.
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Jurczak, Anna Aleksandra. "Wyuczona bezradność człowieka a jego rola w organizacji." Ogrody Nauk i Sztuk 9 (August 15, 2019): 178–88. http://dx.doi.org/10.15503/onis2019.178.188.
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Teza. „Wyuczona bezradność” stała się zjawiskiem, które w XXI wieku jest ściśle związane ze sposobem funkcjonowania pracownika we wszystkich organizacjach (tak w dużych, jak i w małych firmach), ale także z ryzykiem, z którym muszą liczyć się osoby zarządzające bądź działy zasobów ludzkich. Sam problem dotyczy także przedstawicieli wolnych zawodów i osób samozatrudnionych. Artykuł ukazuje sposób funkcjonowania jednostki wykazującej wyuczoną bezradność oraz różnego rodzaju deficyty, na które jest ona narażona.
Omówione koncepcje. Na potrzeby artykułu zostały omówione koncepcje wyuczonej bezradności (M. E. P. Seligman; L. Y. Abramson i J. Teasdale; M. Kofta i G. Sędek) oraz konstrukty Ja (Ja podmiotowe, Ja przedmiotowe, Ja idealne, Ja realne, Ja powinnościowe).
Wyniki i wnioski. „Wyuczona bezradność” jest czynnikiem, który w znaczący sposób wpływa na kondycję psychiczną człowieka. Mechanizm ten znajduje negatywne odzwierciedlenie w samoocenie człowieka, co w dużym stopniu modyfikuje jego motywację oraz chęć do działania. W rzeczywistości organizacyjnej wspomniane aspekty w sposób bezpośredni przekładają się na efektywność pracy i lojalność pracowniczą, co odbija się na jakości świadczonych usług i migracji kadry.
Oryginalność/wartość poznawcza podejścia. Połączenie tematyki z zakresu psychologii organizacji i psychologii zarządzania, która znajduje swoje odzwierciedlenie w zmieniającej się rzeczywistości pracowników firm, zarówno tych małych, jak i dużych. Ukazuje ono mechanizm funkcjonowania człowieka oraz jego szanse i zagrożenia we współczesnym świecie.
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Herok, Piotr. "Summary Statements in the Gospel of Matthew." Biblical Annals 13, no. 4 (October 27, 2023): 617–33. http://dx.doi.org/10.31743/biban.14912.
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This article examines the summary statements in the first gospel. The investigation aims to establish a precise set of Matthean texts belonging to this literary genre. Following a presentation of a variety of solutions (R. Schnackenburg, J. Gnilka, E. Schweizer, D.A. Hagner, R.H. Gundry, J. Nolland, A. Paciorek, U. Luz, R.T. France, W.D. Davies and D.C. Allison, C.S. Keener, G.R. Osborne, C.A. Evans, S. Grasso, W. Egger, B. Gerhardsson, L. Novakovic), literary considerations are examined against the background of various scholarly propositions, giving precise criteria to denote a given gospel text as a summary. On this basis, eight Matthean texts are proposed as summaries – (1) 4:23–25, (2) 8:16–17, (3) 9:35–36, (4) 12:15–21, (5) 14:13–14, (6) 14:34–36, (7) 15:29–31, and (8) 19:1–2 – while showing their thematic interpenetration and mutual dependence.
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Maksymowicz, Agata, and �ucja Kapralska. "AKTYWNO�� JAKO STRATEGIA POMY�LNEGO STARZENIA SI� W �WIETLE INTERNETOWYCH RAD I WSKAZ�WEK DLA SENIOR�W." Studia Humanistyczne AGH 22, no. 2 (2023): 29–46. http://dx.doi.org/10.7494/human.2023.22.2.29.
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Niniejsza praca dotyczy zagadnienia organizacji czasu wolnego os�b przebywaj�cych na emeryturze. Kolejny etap �ycia po zako�czeniu pracy niesie za sob� brak obowi�zk�w zawodowych i powolne wycofywanie si� z pe�nionych dot�d r�l spo�ecznych. Stan ten z jednej strony mo�e by� b�ogos�awie�stwem, z drugiej powodowa� uczucie pustki i stres z powodu tak nadmiaru czasu wolnego, jak i konieczno�ci przystosowania si� do nowej sytuacji. St�d pytanie: co robi� na emeryturze, by przeciwdzia�a� wspomnianym powy�ej stanom i zjawiskom i odnale�� si� w nowej spo�ecznej roli? Analiza zasob�w internetu oraz rynku wydawniczego pozwala znale�� r�ne �r�d�a porad, z kt�rych seniorzy przechodz�cy na emerytur� mog� skorzysta�. W pracy poddano analizie kilka z nich. S� to rady starszych senior�w, poradniki ksi��kowe, portale przeznaczone dla senior�w, strony www i publikacje instytucji aktywizuj�cych osoby starsze, w ko�cu � portale firm komercyjnych zainteresowanych seniorami jako konsumentami. Wi�kszo�� rad wpisuje si� w model staro�ci aktywnej, emerytury zaplanowanej i zorganizowanej pod wzgl�dem zagospodarowania czasu wolnego, przygotowania mentalnego, zdrowotnego oraz administracyjnego. Jest to model po��dany, gdy� pozwala zwi�kszy� szanse na fizyczny i psychiczny dobrostan senior�w, st�d rady takie wydaj� si� wspiera� samodzielne uczestnictwo os�b starszych w �yciu spo�ecznym.
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Khemira, Habib, P. B. Lombard, David Sugar, and Anita N. Azarenko. "Hedgerow Orientation Affects Canopy Exposure, Flowering, and Fruiting of `Anjou' Pear Trees." HortScience 28, no. 10 (October 1993): 984–87. http://dx.doi.org/10.21273/hortsci.28.10.984.
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Mature hedgerows of `Anjou' pear (Pyrus communis L.) trees, planted north(N)-south (S) or east (E)-west (W), were used to study the effect of hedgerow orientation on fruiting and canopy exposure. In 1990, flower bud density tended to be lower on the E-W rows, especially on their N sides. Fruit set (FS) was highest on the S side of E-W rows and lowest on the N side, while the E and W sides of the N-S rows were intermediate. Crop density (CD) had a similar pattern as FS, with more fruit on the S than on the N side of the E-W rows. CD was more evenly distributed between the sides on the N-S hedgerows. Differences in FS and CD between sides were related to different levels of sunlight interception. Light exposure was lowest on the N sides of the E-W rows and highest on the S sides throughout the growing season and especially toward the equinoxes. Increased exposure to the sun on the S and W sides late in the season led to more fruit with solar injury. Fruit from E–W rows were larger and less firm. Accumulated yields over 11 years showed a 21.4% increase in the N-S rows over those of the E-W rows.
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Janiszewski, Piotr, Karol Borzuta, Dariusz Lisiak, Eugenia Grześkowiak, Krzysztof Powałowski, Beata Lisiak, and Łukasz Samardakiewicz. "Jakość mięsa krów w poszczególnych klasach uformowania i otłuszczenia tusz ocenianych według systemu EUROP." Zywnosc Nauka Technologia Jakosc/Food Science Technology Quality 112, no. 3 (2017): 74–83. http://dx.doi.org/10.15193/zntj/2017/112/199.
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Celem pracy było określenie wpływu klas uformowania i otłuszczenia tusz wołowych ocenianych systemem EUROP na jakość mięsa. Badano populację 216 tusz krów rasy nizinnej czarno-białej, reprezentującą trzy klasy uformowania i cztery klasy otłuszczenia w celu określenia zależności pomiędzy jakością mięśnia longissimus thoracis a klasami EUROP. Ocena jakościowa mięśnia obejmowała pomiar pH24, parametry barwy w systemie CIE L*a*b* mierzone przy użyciu spektrofotometru Minolta CR- 400 oraz ocenę marmurkowatości. Na podstawie uzyskanych wyników badań stwierdzono, że zarówno klasyfikacja uformowania, jak i otłuszczenia nie wiążą się z jakością mięsa w klasach R i O oraz w klasach 2, 3 i 4. Wykazano natomiast, że mięso tusz klasy uformowania P oraz klasy otłuszczenia 1 charakteryzowało się wyższym pH24 (p ≤ 0.,01) i większą częstotliwością występowania odchyleń jakościowych typu DFD (ang. Dark Firm Dry). Ponadto mięso tusz klasy otłuszczenia 1 cechowało się najniższymi wartościami parametrów składowych barwy a* i b* (p ≤ 0,01) oraz mniejszą marmurkowatością (p ≤ 0,01) w porównaniu z klasami 3 i 4. Klasy uformowania i otłuszczenia krów miały związek z masą tusz ciepłych, która wzrastała wraz ze zwiększeniem stopnia uformowania (p ≤ 0.,01) oraz ze zwiększeniem stopnia otłuszczenia (p ≤ 0,01). Wielkość powierzchni przekroju mięśnia longissimus thoracis nie zależała od klasy otłuszczenia (p ≤ 0,88), różniła się natomiast w zależności od klasy uformowania i wykazywała istotną różnicę pomiędzy klasą P a klasami O i R (p ≤ 0,05).
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Bąk-Badowska, Jolanta, Ilona Żeber-Dzikowska, and Jarosław Chmielewski. "Evaluation of the degree of healthiness of the pedunculate oak (Quercus robur L.) acorns in the Włoszczowa– Jędrzejów Nature Park and its neighbouring area." Ochrona Srodowiska i Zasobów Naturalnych 28, no. 1 (March 1, 2017): 14–19. http://dx.doi.org/10.1515/oszn-2017-0003.
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Abstract The aim of the study was to demonstrate the degree of healthiness of the pedunculate oak (Quercus robur) acorns found in the Włoszczowa-Jędrzejów Nature Park (abbreviation: W-JOChK) and in the neighbouring area. It was dealt with by making the analysis of health of the acorns (total 3,600). The research material included the samples of fallen down acorns, collected under the pedunculate oaks in Kurzelów (W-JOChK), as well as Żelisławice. The study was conducted from late September 2014 to early October 2015. The analysis of acorns demonstrated that over 50% of the acorns were damaged by insects. The ‘perpetrators’ of the damage proved to be Curculio glandium (Coleoptera: Curculionidae - acorn weevil) and Cydia splendana (Lepidoptera: Tortricidae - chestnut tortrix). It was stated that acorns from the pedunculate oak trees, which were found on the protected area, were twice less frequently inhabited by Curculio glandium than those originating from the trees in Żelisławice - near the industrial firm. The damages caused by Cydia splendana in both study sites were similar in number. The results indicate that the acorns of oaks in more polluted environment are probably more vulnerable to infestation by insects.
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Febby and Sugi Suhartono. "DETERMINAN PEMILIHAN KANTOR AKUNTAN PUBLIK (KAP)." Jurnal Akuntansi 9, no. 2 (August 15, 2020): 1–16. http://dx.doi.org/10.46806/ja.v9i2.758.
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Abstract
In the process of maximizing the value of the company, a conflict of interest between the manager and the shareholders often arises, which is often called an agency problem. This happens because managers prioritize the opposite interests, ownership does not like the personal interests of managers because what managers do will add costs to the company so that it will cause a decrease in corporate profits. Therefore, companies need a corporate monitoring function through external auditors that are used by company managers to reduce agency problems that arise in the company and reduce fraud in the presentation of the company's financial statements. Therefore, this study discusses the factors that can influence the decisions of public accounting firms such as institutional share ownership, managerial stock ownership, largest shareholding, company size, independent commissioners and leverage. The sample in this study consisted of 135 manufacturing companies. Sampling was done by purposive sampling method. The analytical method used is logistic regression analysis using SPSS 20. The conclusion from the results of the analysis in this study is that the largest shareholding has a positive interest in the selection of a public accounting firm.
Keywords: Selection of Public Accounting Firm, Independent Commissioner, Institutional Ownership, Managerial Ownership, Largest Share Ownership, Company Size, Leverage.
References:
Alfian, N., & Suryansyah, A. (2017). "Pengaruh Efektivitas Komite Audit, Ukuran Perusahaan dan Leverage terhadap Pemilihan Auditor Eksternal." Jurnal Akuntansi Dan Investasi, Vol. 2, No. 2, p. 82–93.
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Latchem, Emma Jane, Thomas Kress, Clare P. Grey, Peter A. A. Klusener, Ramachandran Vasant Kumar, and Alexander C. Forse. "Investigating Transport through Separator Membranes in Aqueous Organic Redox Flow Batteries Using NMR Spectroscopy." ECS Meeting Abstracts MA2022-01, no. 48 (July 7, 2022): 1995. http://dx.doi.org/10.1149/ma2022-01481995mtgabs.
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Electricity and heat generation contribute 25% of greenhouse gas emissions globally.1 Redox flow batteries (RFBs) are prospective devices for long-duration energy storage, which is required to integrate more renewable energy sources onto the electricity grid.2 RFBs have a modular design with decoupled power and energy ratings, allowing them to be scaled to suit grid-level energy storage requirements. The development of aqueous organic redox flow batteries (AORFBs), such as quinone-based systems, is gaining momentum because they are potentially cheaper, safer and more sustainable than vanadium-based RFBs.3-5 However, the crossover of redox-active species through the separator membrane can lead to irreversible capacity fade, limiting their lifetime and economic viability.6 It has previously been demonstrated that in situ spectroscopic techniques are powerful tools for determining reaction mechanisms in redox flow batteries.5,7 Here, we explore how solution-state in situ nuclear magnetic resonance (NMR) spectroscopy and solid-state NMR spectroscopy can be used to study the crossover of electrolytes in AORFBs. We demonstrate that in situ solution NMR spectroscopy can be used to characterise transport in operating AORFBs with high temporal resolution and minimal system disturbance. This method can therefore be applied to investigate how crossover is governed by structure-property relationships and the charging protocols used. Furthermore, polymer-electrolyte interactions within the membrane can be probed using complementary solid-state NMR studies. Together, these fundamental studies will ultimately advance our understanding of electrolyte crossover, so that improved separator membranes can be developed. References: Climate Change 2014: Synthesis Report; Pachauri, R. K., Mayer, L., Intergovernmental Panel on Climate Change, Eds.; Intergovernmental Panel on Climate Change: Geneva, Switzerland, 2015. Rugolo, J.; Aziz, M. J., Energy Environ. Sci. 5 7151-7160 (2012). Lin, K.; Chen, Q.; Gerhardt, M. R.; Tong, L.; Kim, S. B.; Eisenach, L.; Valle, A. W.; Hardee, D.; Gordon, R. G.; Aziz, M. J.; Marshak, M. P., Science 349, 1529-1532 (2015). Kwabi, D. G.; Lin, K.; Ji, Y.; Kerr, E. F.; Goulet, M.-A.; De Porcellinis, D.; Tabor, D. P.; Pollack, D. A.; Aspuru-Guzik, A.; Gordon, R. G.; Aziz, M. J., Joule 2, 1894–1906 (2018). Zhao, E. W.; Liu, T.; Jónsson, E.; Lee, J.; Temprano, I.; Jethwa, R. B.; Wang, A.; Smith, H.; Carretero-González, J.; Song, Q.; Grey, C. P., Nature 579, 224–228 (2020). Tan, R.; Wang, A.; Malpass-Evans, R.; Williams, R.; Zhao, E. W.; Liu, T.; Ye, C.; Zhou, X.; Darwich, B. P.; Fan, Z.; Turcani, L.; Jackson, E.; Chen, L.; Chong, S. Y.; Li, T.; Jelfs, K. E.; Cooper, A. I.; Brandon, N. P.; Grey, C. P.; McKeown, N. B.; Song, Q., Mater. 19, 195–202 (2020). Zhao, E. W.; Jónsson, E.; Jethwa, R. B.; Hey, D.; Lyu, D.; Brookfield, A.; Klusener, P. A. A.; Collison, D.; Grey, C. P., Am. Chem. Soc. 143, 1885–1895 (2021).
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Zhou, Yucun, Weilin Zhang, Zheyu Luo, Nicholas Kane, and Meilin Liu. "(Invited) Novel Air Electrode and Catalyst Materials for High-Performance and Durable Regenerative Proton-Conducting Solid Oxide Cells." ECS Meeting Abstracts MA2022-02, no. 47 (October 9, 2022): 1752. http://dx.doi.org/10.1149/ma2022-02471752mtgabs.
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Regenerative solid oxide cells can operate in either a fuel cell mode or an electrolysis mode as needed. Recently, regenerative proton-conducting solid oxide cells (R-PSOCs) have attracted considerable attention due to their potential for efficient and low-cost power and fuel co-generation.1, 2 However, the performance and durability of R-PSOCs are still limited by the lack of highly active and robust air electrode/catalyst materials for dual-mode operation. In this presentation, we will highlight the critical scientific challenges facing the development of efficient and durable air electrode/catalyst materials for R-PSOCs as well as the strategies for dramatically enhancing electrode activity and durability. We will then present our recent progress in the development of new air electrodes 3, 4 as well as the mechanism of electrode reactions and degradation, as revealed by a combination of modeling, simulation, and in situ/operando characterization of electrode processes 5, 6. Catalytic activity, evolution of the surface chemistry, and contaminant (e.g., water and chromium) tolerance of both the conventional La0.6Sr0.4Co0.2Fe0.8O3−δ (LSCF) electrode and the newly developed PrBa0.8Ca0.2Co2O5+δ–BaCoO3−δ (PBCC–BCO) electrode will be discussed. Performance, long-term stability, and degradation mechanism of R-PSOCs using LSCF and PBCC–BCO air electrodes will be reported. We will further introduce our recent progress in the development of highly active and durable catalyst coatings for the air electrodes with significantly enhanced performance and durability under typical operating conditions with the presence of contaminants. Reference: L. Yang, S. Wang, K. Blinn, M. Liu, Z. Liu, Z. Cheng and M. Liu, Science, 2009, 326, 126-129. C. Duan, J. Huang, N. Sullivan and R. O'Hayre, Appl. Phys. Rev., 2020, 7, 011314. Y. Zhou, E. Liu, Y. Chen, Y. Liu, L. Zhang, W. Zhang, Z. Luo, N. Kane, B. Zhao and L. Soule, ACS Energy Lett., 2021, 6, 1511-1520. Y. Zhou, W. Zhang, N. Kane, Z. Luo, K. Pei, K. Sasaki, Y. Choi, Y. Chen, D. Ding and M. Liu, Adv. Funct. Mater., 2021, 2105386. J. H. Kim, S. Yoo, R. Murphy, Y. Chen, Y. Ding, K. Pei, B. Zhao, G. Kim, Y. Choi and M. Liu, Energy Environ. Sci., 2021, 14, 1506-1516. Y. Niu, Y. Zhou, W. Zhang, Y. Zhang, C. Evans, Z. Luo, N. Kane, Y. Ding, Y. Chen and X. Guo, Adv. Energy Mater., 2022, 2103783.
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Yang, Guang Yong. "Design of Carbon Efficient Online Logistics Networks." Advanced Materials Research 962-965 (June 2014): 1444–49. http://dx.doi.org/10.4028/www.scientific.net/amr.962-965.1444.
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With development of internet network, more traditional brick-and-mortar firms sell products via online channels. The key feature of online channels is home delivery, hence, how to design efficient online logistics networks has been the core problem faced by online firms. Furthermore, with increasing pollution of ecological environment and global warming, more carbon emission regulations enacted and implemented also impact firms operation and decision. This paper mainly study online logistics networks design constraint from carbon emission regulations. We analyze the following three types of networks, dropping delivery network (D), delivery network via distribution center (W), and last mile delivery network (L). Combining carbon emission from inbound and outbound transportation, and emission from inventory storage, we design optimal logistics networks and then analyze online logistics network design of Sunfeng best choice firm.
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Gerber, Kinga, Eckard Wimmer, and Aniko V. Paul. "Biochemical and Genetic Studies of the Initiation of Human Rhinovirus 2 RNA Replication: Identification of a cis-Replicating Element in the Coding Sequence of 2Apro." Journal of Virology 75, no. 22 (November 15, 2001): 10979–90. http://dx.doi.org/10.1128/jvi.75.22.10979-10990.2001.
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ABSTRACT We have previously shown that the RNA polymerase 3Dpolof human rhinovirus 2 (HRV2) catalyzes the covalent linkage of UMP to the terminal protein (VPg) using poly(A) as a template (K. Gerber, E. Wimmer, and A. V. Paul, J. Virol. 75:10969–10978, 2001). The products of this in vitro reaction are VPgpU, VPgpUpU, and VPg-poly(U), the 5′ end of minus-strand RNA. In the present study we used an assay system developed for poliovirus 3Dpol (A. V. Paul, E. Rieder, D. W. Kim, J. H. van Boom, and E. Wimmer, J. Virol. 74: 10359–10370, 2000) to search for a viral sequence or structure in HRV2 RNA that would provide specificity to this reaction. We now show that a small hairpin in HRV2 RNA [cre(2A)], located in the coding sequence of 2Apro, serves as the primary template for HRV2 3Dpol in the uridylylation of HRV2 VPg, yielding VPgpU and VPgpUpU. The in vitro reaction is strongly stimulated by the addition of purified HRV2 3CDpro. Our analyses suggest that HRV2 3Dpol uses a “slide-back” mechanism during synthesis of the VPg-linked precursors. The corresponding cis- replicating RNA elements in the 2CATPase coding region of poliovirus type 1 Mahoney (I. Goodfellow, Y. Chaudhry, A. Richardson, J. Meredith, J. W. Almond, W. Barclay, and D. J. Evans, J. Virol. 74:4590–4600, 2000) and VP1 of HRV14 (K. L. McKnight and S. M. Lemon, RNA 4:1569–1584, 1998) can be functionally exchanged in the assay with cre(2A) of HRV2. Mutations of either the first or the second A in the conserved A1A2A3CA sequence in the loop of HRV2 cre(2A) abolished both viral growth and the RNA's ability to serve as a template in the in vitro VPg uridylylation reaction.
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Vemberain, Jesselin, and Yustina Triyani. "ANALISIS PENGARUH PROFITABILITAS, UKURAN PERUSAHAAN, LEVERAGE, DAN KEPEMILIKAN INSTITUSIONAL TAX AVOIDANCE." Jurnal Akuntansi 10, no. 1 (February 28, 2021): 40–62. http://dx.doi.org/10.46806/ja.v10i1.785.
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Tax avoidance is a scheme that aims to minimize the tax burden by taking advantage of loopholes in the tax provisions of a country. Tax avoidance is a practice carried out by individual and corporate taxpayers to reduce the tax burden that must be paid without violating the applicable tax laws. This study aims to analyze the effect of profitability, firm size, leverage and institutional ownership on tax avoidance. This study uses the basic theory : agency theory and compliance theory. The object of the research is a manufacturing company in the consumer goods industry sector which is listed on the Indonesia Stock Exchange during the 2016-2019 period. Researchers conducted descriptive statistical tests, coefficient similarity test (pooling), classical assumption test, multiple linear analysis, and hypothesis testing. The conclusion is that there is sufficient evidence that profitability and firm size have a negative effect on tax avoidance, while there is insufficient evidence that leverage has a positive effect on tax avoidance, and there is not sufficient evidence that institutional ownership has a negative effect on tax avoidance. Key word : profitability, firm size, leverage, institutional ownership, tax avoidance References: Arianandini, P. W., & Ramantha, I. W. (2018). Pengaruh Profitabilitas, Leverage, dan Kepemilikan Institusional Pada Tax Avoidance. E-Jurnal Akuntansi, 22, 2088–2116. https://doi.org/10.24843/eja.2018.v22.i03.p17 Darmayanti, P. P. B., & Merkusiwati, N. K. L. A. (2019). Pengaruh Ukuran Perusahaan, Profitabilitas, Koneksi Politik dan Pengungkapan Corporate Social Responsibility Pada Tax Avoidance. E-Jurnal Akuntansi, 26, 1992–2019. https://doi.org/10.24843/eja.2019.v26.i03.p12 Dewanti, I. G. A. D. C., & Sujana, I. K. (2019). Pengaruh Ukuran Perusahaan, Corporate Social Responsibility, Profitabilitas dan Leverage pada Tax Avoidance. E-Jurnal Akuntansi, 28, 377. https://doi.org/10.24843/eja.2019.v28.i01.p15 Dewi, N. L. P. P., & Noviari, N. (2017). Pengaruh Ukuran Perusahaan, Leverage, Profitabilitas dan Corporate Social Responsibility Terhadap Penghindaran Pajak (Tax Avoidance). E-Jurnal Akuntansi, 21(2), 830–859. https://doi.org/10.24843/EJA.2017.v21.i02.p01 Dewinta, I. A. R., & Setiawan, P. E. (2016). Pengaruh Ukuran Perusahaan, Umur Perusahaan, Profitabilitas, Leverage, Dan Pertumbuhan Penjualan Terhadap Tax Avoidance. E-Jurnal Akuntansi Universitas Udayana, 14(3), 1584–1613. Ekonomi Bung Hatta. (2020). Ukuran Perusahaan (Pengertian, Jenis, Kriteria dan Indikator). https://ekonomi.bunghatta.ac.id/index.php/id/artikel/811-ukuran-perusahaan-pengertian-jenis-kriteria-dan-indikator diakses tanggal 12 Januari 2021 Fiandri, K. A., & Muid, D. (2017). 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Theory of the firm: Managerial Behavior, Agency Costs and Ownership Structure. Journal of Financial Economics, 3(4), 305–360. https://doi.org/https://doi.org/10.1016/0304-405X(76)90026-X Kushariadi, B., & Putra, R. N. (2018). Good Corporate Governance, Leverage, Ukuran Perusahaan Dan Tax Avoidance. Journal of Islamic Finance and Accounting, 1(2), 1-18. https://doi.org/10.22515/jifa.v1i2.1401 Oktamawati, M. (2017). Pengaruh Karakter Eksekutif, Komite Audit, Ukuran Perusahaan, Leverage, Pertumbuhan Penjualan, Dan Profitabilitas Terhadap Tax Avoidance. Jurnal Akuntansi Bisnis, 15(1), 23–40. https://doi.org/10.24167/JAB.V15I1.1349 Pitaloka, S., & Merkusiwati, N. K. L. A. (2019). Pengaruh Profitabilitas, Leverage, Komite Audit, dan Karakter Eksekutif Terhadap Tax Avoidance. E-Jurnal Akuntansi, 27, 1202-1230. https://doi.org/10.24843/eja.2019.v27.i02.p14 Prasetyo, I., & Pramuka, B. A. (2018). Pengaruh Kepemilikan Manajerial, Kepemilikan Institusional, dan Proporsi Dewan Komisaris Independen terhadap Manajemen Laba. Jurnal Ekonomi, Bisnis, Dan Akuntansi (JEBA), 20(2), 1–15. https://doi.org/10.32616/jbr.v1i2.64 Putra, I. G. L. N. D. C., & Merkusiwati, N. K. L. A. (2016). Pengaruh Komisaris Independen, Leverage, Size dan Capital Intensity Ratio pada Tax Avoidance (Studi pada Perusahaan Manufaktur di Bursa Efek Indonesia Periode 2012-2014). E-Jurnal Akuntansi Universitas Udayana, 17(1), 690–714. https://ojs.unud.ac.id/index.php/Akuntansi/article/view/22025 Putri, A. A., & Lawita, N. F. (2019). Pengaruh Kepemilikan Institusional Dan Kepemilikan Manajerial Terhadap Nilai Perusahaan. Jurnal Akuntansi & Ekonomika, 9(1), 68–75. https://doi.org/10.32795/widyaakuntansi.v1i1.249 Putri, V. R., & Putra, B. I. (2017). Pengaruh Leverage, Profitability, Ukuran Perusahaan Dan Proporsi Kepemilikan Institusional Terhadap Tax Avoidance. Jurnal Manajemen Dayasaing, 19(1), 1-11. https://doi.org/10.23917/dayasaing.v19i1.5100 Rahayu, S. K. (2017). Perpajakan (Konsep dan Aspek Formal). Bandung : Rekaya Sains. Riyanto, B. (2013). Dasar-Dasar Pembelanjaan Perusahaan. BPFE. Sintyawati, N. L. A., & Dewi, M. R. (2018). Pengaruh Kepemilikan Manajerial, Kepemilikan Institusional Dan Leverage Terhadap Biaya Keagenan Pada Perusahaan Manufaktur. E-Jurnal Manajemen Universitas Udayana, 7(2), 993-1020. https://doi.org/10.24843/EJMUNUD.2018.v7.i02.p16. Tahar, A., & Rachman, A. K. (2014). Pengaruh Faktor Internal dan Faktor Eksternal Terhadap Kepatuhan Wajib Pajak. Jurnal Akuntansi Dan Investasi, 15(1), 56–67. Tebiono, J. N., & Sukanda, I. B. N. (2019). Faktor-Faktor yang mempengaruhi Tax Avoidance pada Perusahaan Manufaktur yang terdaftar Di BEI. Jurnal Bisnis Dan Akuntansi, 21(1), 121–130. http://jurnaltsm.id/index.php/JBA Utari, N. K. Y. U., & Supadmi, N. L. (2017). Pengaruh Corporate Governance, Profitabilitas Dan Koneksi Politik Pada Tax Avoidance. E-Jurnal Akuntansi Universitas Udayana, 18(3), 2202–2230. Yudea. (2018). Pengaruh Mekanisme Corporate Governance, Ukuran Perusahan, dan Leverage Terhadap Tax Avoidance. Jurnal Reviu Akuntansi Dan Keuangan, 21(2), 115–124. Zain, M. (2005). Manajemen Perpajakan. Jakarta : Salemba Empat.
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Wang, Yan, Chu-Fan Xu, Yu-Jian Liu, Yan-Fei Mao, Zhou Lv, Si-Yuan Li, Xiao-Yan Zhu, and Lai Jiang. "Salidroside Attenuates Ventilation Induced Lung Injury via SIRT1-Dependent Inhibition of NLRP3 Inflammasome." Cellular Physiology and Biochemistry 42, no. 1 (2017): 34–43. http://dx.doi.org/10.1159/000477112.
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Background: Salidroside (SDS) is the main effective ingredient of Rhodiola rosea L with a variety of pharmacologic properties. We aim to investigate the effects of SDS on ventilation induced lung injury (VILI) and explore the possible underlying molecular mechanism. Methods: Lung injury was induced in male ICR mice via mechanical ventilation (30 ml/kg) for 4h. The mice were divided in four groups:(1) Control group; (2) Ventilation group; (3) SDS group; (4) Ventilation with SDS group. SDS (50 mg/kg) was injected intraperitoneally 1h before operation. Mouse lung vascular endothelial cells (MLVECs) were subjected to cyclic stretch for 4h. Results: It was found that SDS attenuated VILI as shown in HE staining, cell count and protein content levels in BAL fluid, W/D and Evans blue dye leakage into the lung tissue. SDS treatment inhibited the activation of NLRP3 inflammasome and subsequent caspase-1 cleavage as well as interleukin (IL)-1β secretion both in vivo and in vitro. Moreover, SDS administration up-regulated SIRT1 expression. Importantly, knockdown of SIRT1 reversed the inhibitory effect of SDS on NLRP3 inflammasome activation. Conclusions: Taken together, these findings indicate that SDS may confer protection against ventilation induced lung injury via SIRT1-de-pendent inhibition of NLRP3 inflammasome activation.
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Gutiérrez-Álzate, Katherine, Iuri L. S. Rosario, Rafael L. C. de Jesus, Leonardo F. Maciel, Stefanie A. Santos, Carolina O. de Souza, Carla Paulo Vieira, Carlos P. Cavalheiro, and Marion Pereira da Costa. "Physicochemical, Rheological, and Nutritional Quality of Artisanal Fermented Milk Beverages with Cupuassu (Theobroma grandiflorum) Pulp and Flour." Foods 12, no. 11 (May 31, 2023): 2217. http://dx.doi.org/10.3390/foods12112217.
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The use of fruits and their by-products in food has dramatically impacted the food industry due to the nutritional benefits and the technological and sensory effects of food matrices. Therefore, this research aimed to evaluate the effects of adding cupuassu (Theobroma grandiflorum) pulp and flour on fermented milk beverages’ physicochemical, microbial, and sensory properties during refrigerated storage (0, 7, 14, 21, and 28 days). Twelve formulations were realized with different percentages of cupuassu pulp (0, 5, 7.5, and 10% w/v) and flour (0, 1.5, and 3% w/v). The treatments with 3% cupuassu flour presented the highest percentages of protein, fat, fiber, and carbohydrates, compared with the samples containing pulp. On the other hand, the addition of pulp increased water retention capacity and color parameters (L*, a*, b*, and C*) and decreased pH and syneresis on day 0 of storage. During storage, the samples with pulp showed increases in pH values, consistency index, and apparent viscosity. In comparison, cupuassu flour addition decreased syneresis values and increased L* and b* during storage, as did pulp. In addition, sample HPHF (10% pulp and 3% cupuassu flour), based on just-about-right, penalty, and check-all-that-apply analyses, improved some sensory attributes of the fermented milk beverage, such as brown color, acid taste, bitter taste, cupuassu flavor, and firm texture. It can be concluded that cupuassu pulp and flour addition improves the physicochemical and sensory quality of fermented milk beverages and can provide nutritional value to the product.
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Rieder, Elizabeth, Aniko V. Paul, Dong Wook Kim, Jacques H. van Boom, and Eckard Wimmer. "Genetic and Biochemical Studies of Polioviruscis-Acting Replication Element cre in Relation to VPg Uridylylation." Journal of Virology 74, no. 22 (November 15, 2000): 10371–80. http://dx.doi.org/10.1128/jvi.74.22.10371-10380.2000.
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ABSTRACT In addition to highly conserved stem-loop structures located in the 5′- and 3′-nontranslated regions, genome replication of picornaviruses requires cis-acting RNA elements located in the coding region (termed cre) (K. L. McKnight and S. M. Lemon, J. Virol. 70:1941–1952, 1996; P. E. Lobert, N. Escriou, J. Ruelle, and T. Michiels, Proc. Natl. Acad. Sci. USA 96:11560–11565, 1999; I. Goodfellow, Y. Chaudhry, A. Richardson, J. Meredith, J. W. Almond, W. Barclay, and D. J. Evans, J. Virol. 74:4590–4600, 2000). cre elements appear to be essential for minus-strand RNA synthesis by an as-yet-unknown mechanism. We have discovered that the cre element of poliovirus (mapping to the 2C coding region of poliovirus type 1; nucleotides 4444 to 4505 in 2C), which is homologous to thecre element of poliovirus type 3, is preferentially used as a template for the in vitro uridylylation of VPg catalyzed by 3Dpol in a reaction that is greatly stimulated by 3CDpro (A. V. Paul, E. Rieder, D. W. Kim, J. H. van Boom, and E. Wimmer, J. Virol. 74:10359–10370, 2000). Here we report a direct correlation between mutations that eliminate, or severely reduce, the in vitro VPg-uridylylation reaction and produce replication phenotypes in vivo. None of the genetic changes significantly influenced translation or polyprotein processing. A substitution mapping to the first A (A4472C) of a conservedAAACA sequence in the loop of PV-cre(2C) eliminated the ability of the cre RNA to serve as template for VPg uridylylation and abolished RNA infectivity. Mutagenesis of the second A (A4473C; AAACA) severely reduced the yield of VPgpUpU and RNA infectivity was restored only after reversion to the wild-type sequence. The effect of substitution of the third A (A4474G; AAACA) was less severe but reduced both VPg uridylylation and virus yield. Disruption of base pairing within the upper stem region of PV-cre(2C) also affected uridylylation of VPg. Virus derived from transcripts containing mutations in the stem was either viable or quasi-infectious.
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Grover, Phulwinder K., Lauren A. Thurgood, David E. Fleming, Wilhelm van Bronswijk, Tingting Wang, and Rosemary L. Ryall. "Intracrystalline urinary proteins facilitate degradation and dissolution of calcium oxalate crystals in cultured renal cells." American Journal of Physiology-Renal Physiology 294, no. 2 (February 2008): F355—F361. http://dx.doi.org/10.1152/ajprenal.00529.2007.
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We have previously proposed that intracrystalline proteins would increase intracellular proteolytic disruption and dissolution of calcium oxalate (CaOx) crystals. Chauvet MC, Ryall RL. J Struct Biol 151: 12–17, 2005; Fleming DE, van Riessen A, Chauvet MC, Grover PK, Hunter B, van Bronswijk W, Ryall RL. J Bone Miner Res 18: 1282–1291, 2003; Ryall RL, Fleming DE, Doyle IR, Evans NA, Dean CJ, Marshall VR. J Struct Biol 134: 5–14, 2001. The aim of this investigation was to determine the effect of increasing concentrations of intracrystalline protein on the rate of CaOx crystal dissolution in Madin-Darby canine kidney (MDCKII) cells. Crystal matrix extract (CME) was isolated from urinary CaOx monohydrate (COM) crystals. Cold and [14C]oxalate-labeled COM crystals were precipitated from ultrafiltered urine containing 0–5 mg/l CME. Crystal surface area was estimated from scanning electron micrographs, and synchrotron X-ray diffraction was used to determine nonuniform strain and crystallite size. Radiolabeled crystals were added to MDCKII cells and crystal dissolution, expressed as radioactive label released into the medium, was measured. Increasing CME content did not significantly alter crystal surface area. However, nonuniform strain increased and crystallite size decreased in a dose-response manner, both reaching saturation at a CME concentration of 3 mg/ and demonstrating unequivocally the inclusion of increasing quantities of proteins in the crystals. This was confirmed by Western blotting. Crystal dissolution also followed saturation kinetics, increasing proportionally with final CME concentration and reaching a plateau at a concentration of ∼2 mg/l. These findings were complemented by field emission scanning electron microscopy, which showed that crystal degradation also increased relative to CME concentration. Intracrystalline proteins enhance degradation and dissolution of CaOx crystals and thus may constitute a natural defense against urolithiasis. The findings have significant ramifications in biomineral metabolism and pathogenesis of renal stones.
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Baas, P. W., and H. C. Joshi. "Gamma-tubulin distribution in the neuron: implications for the origins of neuritic microtubules." Journal of Cell Biology 119, no. 1 (October 1, 1992): 171–78. http://dx.doi.org/10.1083/jcb.119.1.171.
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Axons and dendrites contain dense microtubule (MT) assays that are not attached to a traditional MT nucleating structure such as the centrosome. Nevertheless, the MTs within these neurites are highly organized with respect to their polarity, and consist of a regular 13-protofilament lattice, the two known characteristics of MTs nucleated at the centrosome. These observations suggest either that axonal and dendritic MTs arise at the centrosome, or that they are nucleated locally, following a redistribution of MT nucleating material from the centrosome during neuronal development. To begin distinguishing between these possibilities, we have determined the distribution of gamma-tubulin within cultured sympathetic neurons. gamma-tubulin, a newly discovered protein which is specifically localized to the pericentriolar region of nonneuronal cells (Zheng, Y., M. K. Jung, and B. R. Oakley. 1991. Cell. 65:817-823; Stearns, T., L. Evans, and M. Kirschner. 1991. Cell. 65:825-836), has been shown to play a critical role in MT nucleation in vivo (Joshi, H. C., M. J. Palacios, L. McNamara, and D. W. Cleveland. 1992. Nature (Lond.). 356:80-83). Because the gamma-tubulin content of individual cells is extremely low, we relied principally on the high degree of resolution and sensitivity afforded by immunoelectron microscopy. Our studies reveal that, like the situation in nonneuronal cells, gamma-tubulin is restricted to the pericentriolar region of the neuron. Furthermore, serial reconstruction analyses indicate that the minus ends of MTs in both axons and dendrites are free of gamma-tubulin immunoreactivity. The absence of gamma-tubulin from the axon was confirmed by immunoblot analyses of pure axonal fractions obtained from explant cultures. The observation that gamma-tubulin is restricted to the pericentriolar region of the neuron provides compelling support for the notion that MTs destined for axons and dendrites are nucleated at the centrosome, and subsequently released for translocation into these neurites.
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Wolf, C. P. ": Social Assessment of High Technology: The Superconducting Super Collider in Southeast Michigan . Richard W. Stoffle, Michael W. Traugott, Florence Jensen, Robert Copeland. ; The Superconducting Super Collider at the Stockbridge, Michigan, Site: Community Support and Land Acquisition . Richard W. Stoffle, Michael W. Traugott, Camilla L. Harshbarger, Florence V. Jensen, Michael J. Evans, Paula Drury." American Anthropologist 91, no. 4 (December 1989): 1053–54. http://dx.doi.org/10.1525/aa.1989.91.4.02a00460.
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Paul, Aniko V., Elizabeth Rieder, Dong Wook Kim, Jacques H. van Boom, and Eckard Wimmer. "Identification of an RNA Hairpin in Poliovirus RNA That Serves as the Primary Template in the In Vitro Uridylylation of VPg." Journal of Virology 74, no. 22 (November 15, 2000): 10359–70. http://dx.doi.org/10.1128/jvi.74.22.10359-10370.2000.
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ABSTRACT The first step in the replication of the plus-stranded poliovirus RNA is the synthesis of a complementary minus strand. This process is initiated by the covalent attachment of UMP to the terminal protein VPg, yielding VPgpU and VPgpUpU. We have previously shown that these products can be made in vitro in a reaction that requires only synthetic VPg, UTP, poly(A), purified poliovirus RNA polymerase 3Dpol, and Mg2+ (A. V. Paul, J. H. van Boom, D. Filippov, and E. Wimmer, Nature 393:280–284, 1998). Since such a poly(A)-dependent process cannot confer sufficient specificity to poliovirus RNA replication, we have developed a new assay to search for a viral RNA template in conjunction with viral or cellular factors that could provide this function. We have now discovered a small RNA hairpin in the coding region of protein 2C as the site in PV1(M) RNA that is used as the primary template for the in vitro uridylylation of VPg. This hairpin has recently been described in poliovirus RNA as being an essential structure for the initiation of minus strand RNA synthesis (I. Goodfellow, Y. Chaudhry, A. Richardson, J. Meredith, J. W. Almond, W. Barclay, and D. J. Evans, J. Virol. 74:4590–4600, 2000). The uridylylation reaction either with transcripts of cre(2C) RNA or with full-length PV1(M) RNA as the template is strongly stimulated by the addition of purified viral protein 3CDpro. Deletion of the cre(2C) RNA sequences from minigenomes eliminates their ability to serve as template in the reaction. A similar signal in the coding region of VP1 in HRV14 RNA (K. L. McKnight and S. M. Lemon, RNA 4:1569–1584, 1998) and the poliovirus cre(2C) can be functionally exchanged in the assay. The mechanism by which the VPgpUpU precursor, made specifically on the cre(2C) template, might be transferred to the site where it serves as primer for poliovirus RNA synthesis, remains to be determined.
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Aalen, F. H. A., D. McCourt, Desmond A. Gillmor, Robin E. Glasscock, T. J. Hughes, J. H. Andrews, J. A. K. Grahame, et al. "Reviews of Books." Irish Geography 6, no. 1 (January 3, 2017): 94–107. http://dx.doi.org/10.55650/igj.1969.988.
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IRELAND : A GENERAL AND REGIONAL GEOGRAPHY, by T. W. Freeman, Fourth edition. London : Methuen, 1909. xx + 558 pp. £5.THE IRISHNESS OF THE IRISH, by E. Estyn Evans. Belfast: the Irish Association for Cultural, Economic and Social Relations. 1908. pp. 8. 2s. 6d.ENCYCLOPAEDIA OF IRELAND. Dublin : Allen Figgis, 1968. 463 pp. 120s.AN INTRODUCTION TO MAP READING FOR IRISH SCHOOLS, by R. A. Butlin. Dublin : Longmans, Browne & Nolan Limited, 1968. 123 pp. with four half‐inch O.S. map extracts. 10s.AN OUTLINE OF THE RE‐TRIANGULATION OF NORTHERN IRELAND, by W. R. Taylor. Belfast: Her Majesty's Stationery Office, 1907. 27 pp. 4s. 6d.A REVIEW OF DRUMLIN SOILS RESEARCH, 1959–1966, by J. Mulqueen and W. Burke. Dublin : An Foras Talúntais, 1967. 57 pp. 5s.FAMILY AND COMMUNITY IN IRELAND, by Conrad M. Arensberg and Solon T. Kimball. Harvard : the University Press, 2nd edition, 1968. 417 pp. $7.95.LONDONDERRY AREA PLAN. James Munce partnership. Belfast, 1968. 156 pp. 32s 6d.AN AGRICULTURAL ATLAS OF COUNTY GALWAY, by J. H. Johnson and B. S. MacAodha. Social Sciences Research Centre, University College, Galway, Research Papers Numbers 4 and 5. Dublin : Scepter Publishers Ltd., 1967. 66 pp.LIFE IN IRELAND, by L. M. Cullen. London : B. T. Batsford Ltd. New York : G. P. Putnams's Sons. 1968. xiv + 178 pp. 25s.PHASES OF IRISH HISTORY, by Eoin MacNeill. Dublin : Gill, 1968. 364 pp. 10s 6d.ANGLO‐IRISH TRADE, 1660–1800, by L. M. Cullen. Manchester : the University Press, 1968. 252 pp. 60s.IRISH PEASANT SOCIETY, by K. H. Connell. Oxford: The Clarendon Press, 1968. 167 pp. 35s.THE COUNTY DONEGAL RAILWAYS (Part One of a History of the Narrow‐Gauge Railways of North‐West Ireland), by Edward M. Patterson. Newton Abbot: David and Charles : 2nd edition, 1969. 208 pp. 40s.THE IRISH LIGHTHOUSE SERVICE, by T. G. Wilson. Dublin: Allen Figgis, 1908. 149 pp. 42s.REPORT OF THE DEPUTY KEEPER OF THE PUBLIC RECORDS, 1960–65. Cmd. 521. 1908. 244 pp. 17s Cd. SOURCES FOR THE STUDY OF LOCAL HISTORY IN NORTHERN IRELAND. 102 pp. 2s 6d. IRISH ECONOMIC DOCUMENTS. 37 pp. 1s. All published by Her Majesty's Stationery Office, Belfast.IRISH JOURNAL OF AGRICULTURAL ECONOMICS AND RURAL SOCIOLOGY, Volume I, numbers 1 (1967), 2 and 3 (1968). Dublin : An Foras Talúntais (Agricultural Institute). Each number 10s.JOURNAL OF THE KERRY ARCHAEOLOGICAL AND HISTORICAL SOCIETY. No. 1, 1968, 116 pp. No. 2, 1969, 150 pp.Maps and map cataloguesTHE KINGDOME OF IRELAND, by John Speed. Dublin : Bord Fáilte Éireann, 1966. Obtainable from the Library, Trinity College, Dublin. 12s. 6d.MAP CATALOGUE. Ordnance Survey of Northern Ireland. Belfast: Her Majesty's Stationery Office, 1908. 40 pp. 5s.CATALOGUE OF SMALL SCALE MAPS AND CHARTS. Ordnance Survey of Ireland. Dublin : Government Publications Office, 1968. 11pp. 1s.EIRE. Dublin : Ordnance Survey office. 1:350,000. 1968. 58 × 43 in. £5 10s.NORTHERN IRELAND, Sheet 4 (the south‐east). 1:126,720. 1968. 40 × 30 in. Paper, flat, 5s. Ordnance Survey of Northern Ireland, Belfast.WICKLOW AND DISTRICT. Teaching extract. l:63,360, fully coloured. 1968. 1s.ICAO. Aeronautical chart: Ireland 1:500,000. 1968. Two sheets, 38 in. 29 in and 40 in. × 29 in. 5s.ICAO. World aeronautical chart: Ireland. 1:1,000,000. 1968. 21 1/2 in. × 27 in. 5s.INTERNATIONAL MAP OF THE WORLD. Ireland. 1:1,000,000. 1968. 183/4 in. 29 1/4 in. 5s.
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Павелків, Роман, and Інна Петренко. "ПЕДАГОГІЧНІ ПІДХОДИ ДО ФОРМУВАННЯ ОСВІТНЬОГО ПРОСТОРУ: ТЕОРЕТИЧНИЙ АНАЛІЗ ПРОБЛЕМИ." Інноватика у вихованні 1, no. 13 (June 15, 2021): 39–49. http://dx.doi.org/10.35619/iiu.v1i13.371.
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У статті здійснено теоретичний аналіз педагогічних підходів до формування освітнього простору. Освітній простір – це складна система, що розвивається, це динамічна єдність суб’єктів освітнього процесу і їх відносин. Освітній простір містить у собі: просторово-семантичний компонент (архітектурно-естетичну організацію життєвого простору учнів (архітектура шкільних будинків, організація класної кімнати, дизайн інтер’єру і т. п.); символічний простір школи (різні символи, настінна інформація і т. п.); змістовно-методичний компонент (концепції навчання, виховання, навчальні програми, плани, підручники і т. п.); форми й методи організації освіти; комунікаційно-організаційний компонент.
З’ясовано, що у зв’язку зі зміною змісту освіти змінюється підхід до формування освітнього простору й форма його організації. У педагогіці підхід є системотворчою категорією, що визначає процесуальну закономірність компонентів освітньої системи, а також є способом розгляду педагогічної діяльності. Як особлива наукова категорія підхід уважається основою формування не тільки будь-якої педагогічної теорії, але й практики: саме підхід лежить в основі формування принципів і методів навчання, виховання, освіти. На практиці від правильного розуміння сутності підходу залежить точне визначення його місця й ролі серед інших феноменів педагогічної діяльності, таких, як мета, принцип, форма, метод, прийом.
Схарактеризовано основні педагогічні підходи до визначення сутності освітнього простору, як-то: культурно-гуманістичний (Н. Щиголєва); системно-цілісний (Г. Сєріков); ментально-емоційний (Р. Еверман, Ю. Копиленко й ін.); особистісно-розвивальний (J. Sechrest, J. L. Parker); соціально-географічний (В. Кінєльов, О. Сошнєва); дистанційний (A. W. Bates, T. Evans, J. E. Lee й ін.); локально-постерний (Л. Санкін, M. Cesaronі, E. Kopachkov), просторовий (Р. Пономарьов), коадаптаційний підхід (Л. Іванова).
Доведено, що відмінностями між зазначеними підходами є: визначення сутності, основного ядра освітнього простору; розуміння місця освітнього середовища і його ролі, ієрархії структурних компонентів, механізмів формування освітнього простору, ролі педагога (від активного учасника до посередника).
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Bélair, G., L. Simard, and J. D. Eisenback. "First Report of the Barley Root-Knot Nematode Meloidogyne naasi Infecting Annual Bluegrass on a Golf Course in Quebec, Canada." Plant Disease 90, no. 8 (August 2006): 1109. http://dx.doi.org/10.1094/pd-90-1109a.
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Annual bluegrass, Poa annua L., is an important component of the vegetation on golf course greens and fairways throughout Canada and is widely distributed across the world (2). The barley root-knot nematode, Meloidogyne naasi Franklin, infects and damages cereals such as barley (Hordeum vulgare), sorghum (Sorghum vulgare), and wheat (Triticum durum and T. vulgare), mainly in Europe. Of the root-knot species, M. naasi in particular, prefers grasses over other hosts, and infestations of this nematode can reduce the growth and vigor of turfgrasses (1). In July 2005, annual bluegrass at Beaconsfield Golf Club in Pointe Claire (45°26′N, 73°50′W), Quebec showed signs of an unidentified disease. Irregular yellowish/chlorotic patches were observed on the collar of one golf green. Lower turfgrass density in the turf areas with symptoms was noted. When roots were examined under a dissecting microscope, galling was observed. Upon dissection of washed galls, root-knot nematode egg masses and mature females inside the roots were observed. Nematode extractions of the soil from two samples of 50 g from the green and around the collar and perimeter were also done by the modified Baermann pan method. No juveniles were recovered from soil samples from the healthy area and an average of 400 and 1,500 juveniles/kg dry soil were counted in collar and perimeter samples of the patches. Morphological identification of mature females and juveniles were performed and confirmed to be M. naasi. Currently, there are no regulations to control the introduction of this nematode into Canada. To our knowledge, this is the first report of the occurrence of M. naasi in Canada where it is causing noticeable damage to turfgrass in Quebec. A soil survey is currently underway to examine the distribution of this nematode on golf course turfgrasses in Ontario and Quebec. References: (1) R. Cook and G. W. Yeates. Nematode pests of grassland and forage crops. Pages 305–350 in: Plant Parasitic Nematodes in Temperate Agriculture. K. Evans et al., eds. CAB International, Wallingford, UK, 1993. (2) S. I. Warwick. Can. J. Plant Sci. 59:1053, 1979.
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Hogrefe, Christin, Thomas Waldmann, Miguel Benavente Molinero, Ludwig Wildner, Peter Axmann, and Margret Wohlfahrt-Mehrens. "Analysis of Graphite Lithiation Behaviour in Li-Ion Full Cells Using a Novel Cross-Sectional in Situ Optical Microscopy Method." ECS Meeting Abstracts MA2022-02, no. 3 (October 9, 2022): 238. http://dx.doi.org/10.1149/ma2022-023238mtgabs.
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In Li-Ion batteries, the graphite anode undergoes chromatic changes from grey (unlithiated graphite) to blue (LiC18) to red (LiC12) to gold (LiC6) during lithiation.1 When charged with high current rates, lithiation gradients are observable due to mass transport limitations within the anode.2 Due to high lithiation degrees at the surface, the anode potential decreases locally and the possibility of Li deposition is increased.3 We introduce a new in situ optical microscopy set-up, which allows a direct observation of the cross-section of Li-ion full cells in combination with simultaneous recording of electrochemical data (Figure 1). Extensive analysis of the chromatic changes from the graphite electrode surface to the current collector gives insights into the lithiation processes on electrode and particle level. The set-up was validated by comparing the electrochemical results with data from coin full cells. The propagation of lithiation fronts for LiC12 (~ 3300 µm2 min-1) and LiC6 (~1260 µm2 min-1) at 1C through the graphite electrode coating were determined as well as the estimation of apparent solid-state diffusion coefficients in the order of 10-10 cm2 s-1 from analyzing the phase propagation within single particles at C/10. Additionally, the expansion of all components of the whole cell can be observed individually. We found that the graphite contributes mainly to the cell expansion, both irreversibly (4%) and reversibly (4-13%). Directly observing the described phenomena in the full cell can give insights into aging mechanisms of the materials. Figure 1 Exemplary image from the video at the end of charge of an in situ measurement (cycling at C/10) of a graphite-NMC 622 full cell cross-sections. References P. Maire, A. Evans, H. Kaiser, W. Scheifele and P. Novák, J. Power Sources, 155(11), A862 (2008). M. Weiss, R. Ruess, J. Kasnatscheew, Y. Levartovsky, N. R. Levy, P. Minnmann, L. Stolz, T. Waldmann, M. Wohlfahrt-Mehrens, D. Aurbach, M. Winter, Y. Ein-Eli and J. Janek, Adv. Energy Mater., 11(n/a), 2101126 (2021). T. Gao, Y. Han, D. Fraggedakis, S. Das, T. Zhou, C.-N. Yeh, S. Xu, W. C. Chueh, J. Li and M. Z. Bazant, Joule (2021). Figure 1
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Sibuea, Kezia, and Rizka Indri Arfianti. "PENGARUH KUALITAS AUDIT, UKURAN PERUSAHAAN, KOMPLEKSITAS PERUSAHAAN DAN RISIKO PERUSAHAAN TERHADAP AUDIT FEE." Jurnal Akuntansi 10, no. 2 (August 31, 2021): 126–40. http://dx.doi.org/10.46806/ja.v10i2.804.
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Companies that hire an auditor to audit their financial statements are charged an audit fee. The audit fee is a payment given by the company to the auditor in exchange for his or her services. The purpose of this study is to discover if audit quality, firm size, complexity, and company risk all play a role in setting audit costs for financial statements. This study used a purposive sampling technique using a sample of 54 manufacturing businesses listed on the Indonesia Stock Exchange for the 2017-2019 period. Data analysis techniques used include the descriptive analysis test, classical assumption test, multiple regression analysis test, simultaneous test (f-test), and partial test (t-test). According to the findings of the study, audit quality, firm size, and firm complexity all have a significant positive impact on audit fees. While the firm risk variable is not proven to have an effect on audit fees.
Keywords: Audit fee, Audit quality, Company size, Company complexity, Company risk.
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Mücker., Jan P. "C. R. EVANS, L. S. FINN, D. W. HOBILL (eds.): Frontiers in numerical relativity. Cambridge University Press, Cambridge, New York, New Rochelle, Melbourne, Sydney, XIV + 435 Seiten, Preis: f 35.00. ISBN 0-521-36666-." Astronomische Nachrichten: A Journal on all Fields of Astronomy 311, no. 6 (1990): 350. http://dx.doi.org/10.1002/asna.2113110605.
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Searle, D. J., and P. J. Woods. "Detailed Documentation of a Holocene Sea-Level Record in the Perth Region, Southern Western Australia." Quaternary Research 26, no. 3 (November 1986): 299–308. http://dx.doi.org/10.1016/0033-5894(86)90091-8.
Full textAbstract:
Holocene prograded coastal sequences at Becher/Rockingham, southern Western Australia, contain a detailed record of sea level over the last 6400 yr. Radiocarbon dating and use of a distinct stratigraphic indicator as a sea-level marker permit reconstruction of sea-level history and suggest that the sea was at least 2.5 m above present datum about 6400 yr B.P. before falling to its present level. No evidence was found for eustatic fluctuations of the scale proposed by R. W. Fairbridge [1961,in“Physics and Chemistry of the Earth” (L. H. Ahrens, F. Press, K. Rankema, and S. K. Runcorn, Eds.), Vol. 4, pp. 99–185, Pergamon, Oxford]. The sea-level record preserved on this coast can be explained by hydro-isostasy, tectonism, or eustasy, acting individually or in concert. Without a fixed reference point or analogous data from other locations, a firm conclusion on which mechanism(s) has(have) operated could not be reached. Published sea-level data from this and other coasts are often insufficiently detailed to compare with this study. Application of the techniques of this study to analogous sedimentary sequences elsewhere will provide data of comparable accuracy that would contribute to a more precise understanding of relative sea-level movements in the late Quaternary.
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Maddu, Akhiruddin, Sejahtera Ahmad, and Tony Sumaryada. "Development of Glucose Meter Using Boric Acid-Modified Carbon Dots as Fluorescent Probe." Photonics Letters of Poland 13, no. 3 (September 30, 2021): 49. http://dx.doi.org/10.4302/plp.v13i3.1080.
Full textAbstract:
A glucose meter has been developed utilizing boric acid-modified carbon dots as a fluorescence probe. Boric acid-modified carbon dots produces varying fluorescence emission with varying glucose concentration in water. Boric acid-modified carbon dots mixed with glucose addition was excited by a violet laser (405 nm), then the emission intensity was detected by a photodetector to be converted to an electrical signal that as an input signal for a microcontroller for glucose concentration measurement. The output voltage of the glucose meter is corresponding to the fluorescence emission measured by using a spectrofluorometer with glucose concentration in the boric acid-modified carbon dots. Full Text: PDF ReferencesH. Teymourian, A. Barfidokht, J. Wang, "Electrochemical glucose sensors in diabetes management: an updated review (2010–2020)", Chem. Soc. Rev. 49, 7671 (2020). CrossRef D.C. Klonoff, "Overview of Fluorescence Glucose Sensing: A Technology with a Bright Future", J Diabetes Sci. Technol. 6(6), 1242 (2012). CrossRef J.C. Pickup, F. Hussain, N.D. Evans, O.J. Rolinski, David J.S. Birch, "Fluorescence-based glucose sensors", Biosens. Bioelectron. 20, 2555 (2005). CrossRef H. Fang, G. Kaur, B. Wang, "Progress in Boronic Acid-Based Fluorescent Glucose Sensors", J. Fluoresc. 14(5), 481 (2004). CrossRef T. Kawanishi, M.A. Romey, P.C. Zhu, M.Z. Holody, S. Shinkai, "A Study of Boronic Acid Based Fluorescent Glucose Sensors", J. Fluoresc. 14(5), 499 (2004). CrossRef A.S. Krishna, P.A. Nair, C. Radhakumary, K. Sreenivasan, "Carbon dot based non enzymatic approach for the detection and estimation of glucose in blood serum", Mater. Res. Express 3(1), 055001 (2016). CrossRef G.P.C. Mello, E.F.C. Simões, D.M.A. Crista, J.M.M. Leitão, L. Pinto da Silva, J.C.G. Esteves da Silva, "Glucose Sensing by Fluorescent Nanomaterials", Crit. Rev. Anal. Chem. 49(6), 542 (2019). CrossRef X. Shan, L. Chai, J. Ma, Z. Qian, J. Chen, H. Feng, "B-doped carbon quantum dots as a sensitive fluorescence probe for hydrogen peroxide and glucose detection", Analyst 139, 2322 (2014). CrossRef J. Dong, S. Li, H. Wang, Q. Meng, L. Fan, H. Xie, C. Cao, W. Zhang, "Simple Boric Acid-Based Fluorescent Focusing for Sensing of Glucose and Glycoprotein via Multipath Moving Supramolecular Boundary Electrophoresis Chip", Anal. Chem. 85(12), 5884 (2013). CrossRef Y. Cui, F. Chen, X-B. Yin, "A ratiometric fluorescence platform based on boric-acid-functional Eu-MOF for sensitive detection of H2O2 and glucose", Biosens. Bioelectron. 135, 208 (2019). CrossRef
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Kusuma Wijayanti, Puspita Adhi, and Surya Cahyadi. "Antecedents-Consequences Modification to Decrease Hyper-activity and Improve Attention of Child with ADHD." JPUD - Jurnal Pendidikan Usia Dini 13, no. 2 (November 30, 2019): 232–48. http://dx.doi.org/10.21009/jpud.132.03.
Full textAbstract:
The prevalence of ADHD children increases every year. Some researchers have shown that psychosocial behavior therapy (antecedents-consequences modification) was effective to decrease hyperactivity and increase attention to ADHD children. This study aims to find out the effectiveness of antecedents-consequences modification by parents and teachers to decrease hyperactivity and increase attention to a 6 years old boy with ADHD. The study was a single case experimental design. Psychosocial behavior therapy has been used with antecedents-consequences modification. The antecedents-consequences modification was applied by teacher at school and parents at home. Data were analyzed using Wilcoxon Signed Rank Test. Results showed that there’s a significant decrease of hyperactivity behavior and significant increase of doing his assignment both at school and also at home. Not only about the content of behavior therapy itself, but how to give the therapy is important. Parents and teacher should do the therapy consistently, immediately, specifically and saliency to reach the target of intervention.
Keywords: ADHD Children, Antecedents, Consequences, Modification
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Rajagopalan, P., F. D. Boudinot, C. K. Chu, B. C. Tennant, B. H. Baldwin, and R. F. Schinazi. "Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks." Antimicrobial Agents and Chemotherapy 40, no. 3 (March 1996): 642–45. http://dx.doi.org/10.1128/aac.40.3.642.
Full textAbstract:
The woodchuck (Marmota monax) has proven to be a suitable animal model for studying hepatitis B virus (HBV) infection owing to similarities in the course of infection between woodchuck hepatitis virus (WHV) in woodchucks and HBV in humans. (-)-beta-L-2',3'-Dideoxy-3'-thiacytidine (3TC; lamivudine) is a nucleoside analog which has demonstrated antiviral activity against HBV as well as human immunodeficiency virus (HIV). The purpose of the present investigation was to characterize the pharmacokinetics of 3TC following intravenous and oral administration of 20 mg of 3TC per kg of body weight to woodchucks. Following intravenous administration, the concentrations of 3TC in plasma declined, with a terminal half-life of 2.84 +/- 0.85 h (mean +/- standard deviation). The systemic clearance and steady-state volume of distribution of 3TC were 0.22 +/- 0.078 liters/h/kg and 0.75 +/- 0.13 liters/kg, respectively. The renal clearance of the nucleoside analog was 0.063 +/- 0.016 liters/h/kg. The oral bioavailability of 3TC ranged from 18 to 54%. Allometric relationships between pharmacokinetic parameters and body weight developed by Hussey et al. (E.K. Hussey, K.H. Donn, M.J. Daniel, S.T. Hall, A.J. Harker, and G.L. Evans, J. Clin. Pharmacol. 34:975-977, 1994) were augmented by including data from woodchucks, monkeys (S.M. Blaney, M.J. Daniel, A.J. Harker, K. Godwin, and F.M. Balis, Antimicrob. Agents Chemother. 39:2779-2782, 1995), and additional data from rats (P. Rajagopalan, L. Moore, C.K. Chu, R.F. Schinazi, and F.D. Boudinot, submitted for publication). Interspecies scaling of the pharmacokinetic parameters of 3TC demonstrated a good correlation between clearance (0.74 . W0.76 [where W is body weight]; r = 0.93; P < 0.025), apparent volume of distribution (1.62 . W0.81; r = 0.98; P < 0.005), and steady-state volume of distribution (1.09 . W0.94; r = 0.99; P < 0.05) and species body weight. The allometric relationships for clearance and volume of distribution at steady state predicted the observed pharmacokinetic parameters in humans quite well; however, the apparent volume of distribution was underestimated in humans. Thus, the pharmacokinetic data obtained with the woodchuck HBV animal model should be useful for designing clinical trials.
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Soffianningrum, Imbarsari, Yufiarti, and Elindra Yetti. "ECE Educator Performance: Teaching Experience and Peer Teaching Ability through Basic Tiered Training." JPUD - Jurnal Pendidikan Usia Dini 16, no. 1 (April 30, 2022): 52–68. http://dx.doi.org/10.21009/jpud.161.04.
Full textAbstract:
ABSTRACT: Teacher performance has been the focus of educational policy reforms in recent decades for the professional development of teachers. The purpose of this study was to determine the effect of teaching experience and peer teaching skills on basic training on ECE teacher performance. This research uses ex-post facto quantitative method of comparative analysis and design by level. The population is all ECE teachers who attend basic-level education and training in Tangerang Regency, totaling 3358 people consisting of 116 male teachers and 3,242 female teachers. Data collection techniques using a questionnaire with data analysis include descriptive analysis. Requirements test analysis and inferential analysis. The results show that there are differences in the performance of ECE teachers between teachers with more than five years of teaching experience and less than five years, in the group of ECE teachers with high peer teaching skills and low peer teaching skills. The implication of this research is that it is hoped that various parties will become more active in aligning ECE teacher training so that it can improve the performance of ECE teachers.
Keywords: teaching experience, peer teaching ability, tiered basic training, ECE teacher performance
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Hill, G. N., W. R. Henshall, and R. M. Beresford. "Manipulating rainfall to study symptom expression of Botrytis cinerea infection in wine grapes." New Zealand Plant Protection 70 (July 26, 2017): 301–9. http://dx.doi.org/10.30843/nzpp.2017.70.64.
Full textAbstract:
Botrytis cinerea infection of wine grapes can result in a variety of symptoms. The most common symptom is botrytis bunch rot (BBR), where infected berries rot and shrivel, and eventually produce fungal sporulation. Another symptom is slip skin, where the skins of infected ripe berries slide easily from the pulp. It is hypothesised that a reduction in osmotic potential in grape berries due to late-season rainfall leads to slip skin symptom development. Hyphal growth of B. cinerea on osmotically adjusted agar was inhibited at osmotic potentials associated with near-ripe berries. Vine sheltering was used in a research vineyard to manipulate rainfall artificially and to alter berry sugar content in Vitis vinifera Sauvignon blanc vines, with the aim of increasing osmotic potential and altering symptom expression. Both BBR and slip skin symptoms were affected by the various sheltering conditions, with sheltered vines having lower BBR and higher slip skin at harvest.
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THE PERSONALITY OE IRELAND. HABITAT. HERITAGE AND HISTORY by E. Estyn Evans. Cambridge: University Press. 1973. 123 pp. £2.70. Reviewed by: T. J. HughesHISTORY IN THE ORDNANCE MAP: AN INTRODUCTION FOR IRISH READERS, by John H. Andrews. Dublin : the Ordnance Survey, l974. 63 pp. £1.00. Reviewed by: Gordon L. DaviesINISHKILLANE — CHANGE AND DECLINE IN THE WEST OF IRELAND. by Hugh Brody. London: Allen Lane, the Penguin Press, 1973. 286 pp. £2.95. Reviewed by: William J. SmythNORTHERN IRELAND. by M.A. Busteed (PROBLEM REGIONS OF EUROPE. edited by D. I. Srargill). London: Oxford University Press, 1974. 48 pp. £1.00. Reviewed by: N. C. MitchclHAS IRELAND A POPULATION PROBLEM ? by R. E. Blackith. P. Dowding and F. J. Purcell. Dublin: the Irish Conservation Society, 1973. 57 pp. £0.50. Reviewed by: A. J. ParkerTHE DOWNSHIRE ESTATES IN IRELAND, 1801–1845, by W. A. Maguire. Oxford: the Clarendon Press, 1972. 284 pp. £0.00. Reviewed by: R. H. BuchananOFFICE LOCATION IN IRELAND: THE ROLE OF CENTRAL DUBLIN, by Michael J. Bannou. Dublin: An Foras Forbartha, 1973. 144 pp. £1.75. Reviewed by: A. J. ParkerIRISH RAILWAYS SINCE 1916. by Michael H. C. Baker. London: Ian Allan. 1972. 224 pp. £3.16. Reviewed by: James E. KillenA RAILWAY ATLAS OF IRELAND, by S. Maxwell Hajducki. Newton Abbot: David and Charles. 1074. 70 pp. £4.25. Reviewed by: James E, KillenACHILL. by Kenneth McNally. Newton Abbot : David and Charles. 1973. 239 pp. £3.50.; THE ARAN ISLANDS, by Daphne Pochin Mould. Newton Abbot: David and Charles. 1072. 171 pp. £2.75. Reviewed by: J. P. HaughtonTHE LIBERTIES OF DUBLIN, edited by Elgy Gillespie. Dublin : E. and T. O'Brien Ltd.. 11 Clare Street. 1973. 1211 pp. £1.65. Reviewed by: J. A. K. GrahameAN ATLAS OF IRISH HISTORY, by Ruth Dudley Edwards. London: Methuen 1973. 261 pp. £2.70 (hardback), £1.50 (paperback). Reviewed by: A. A. HornerTHE HERITAGE OF HOLY CROSS, by Geraldine Carville. Belfast : Blackstaff Press, 1973. 175 pp. £5 (hardback), £1.75 (paperback). Reviewed by:STUDIES OF FIELD SYSTEMS IN THE BRITISH ISLES,edited by A. R. H. Baker and R. A. Butlill. Cambridge: the University Press, 1973. 702 pp. £11.00. Reviewed by: J. H. AndrewsMAN MADE THE LAND: ESSAYS IN ENGLISH HISTORICAL GEOGRAPHY, edited by Man R. H. Baker and J. B. Harley. Newton Abbot : David & Charles, 1973. 208 pp. with 263 illustrations. £6.25.; ENGLISH LANDSCAPES, by W. G. Hoskins. London: British Broadcasting Corporation. 1973. 120 pp. with 84 illustrations. £0.75. Reviewed by: Kobin K. GlasscockTHE GLYNNS: Journal of the Glens of Antrim Historical Society, Vol. 1. 1973. 45 pp. £0.50. Reviewed by: J. A. K. Grahame
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Angelo, Stefanus, and Nunung Nuryani. "PENGARUH PILIHAN METODE NILAI WAJAR PROPERTI INVESTASI TERHADAP NILAI PERUSAHAAN REAL ESTATE." Jurnal Akuntansi 10, no. 2 (August 31, 2021): 90–97. http://dx.doi.org/10.46806/ja.v10i2.801.
Full textAbstract:
IAS 40 (adopted in PSAK 13, 2012) about investment properties allowing companies to choose the method of measuring their investment properties, namely the cost method and the fair value method. Side that oppose fair value method argue that fair value is unreliable and costly. The purpose of this study, therefore, is to examine the relevance of the fair value accounting choice method and determinants that affect of fair value accounting choice method for investment property. This research is using secondary data observation technique which acquired from annual financial reports for real estate, manufacturing, and trading sector companies listed on the Indonesia Stock Exchange during the 2012-2016 period. By using judgment sampling method, the research sample tested were 48 companies (19 real estate companies, 15 manufacturing companies, and 14 trading companies). The results of this research shows that fair value accounting choice method has a positive significant on firm value. In that case shows that fair value accounting choice have a value relevance so it can help investor to make a investment decision. For determinants of fair value accounting choice, that firm size variables has significant positive and leverage significant negatively with determinants of fair value accounting choice while big four has no effect on determinants of fair value accounting choice.
Keywords:
Value relevance, Investment property, Firm size, Leverage, Big four.
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White, Brian S., Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, et al. "Abstract 5407: A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis." Cancer Research 83, no. 7_Supplement (April 4, 2023): 5407. http://dx.doi.org/10.1158/1538-7445.am2023-5407.
Full textAbstract:
Abstract Patient-derived xenografts (PDXs) model human intra-tumoral heterogeneity in the context of the intact tissue of immunocompromised mice. Histological imaging via hematoxylin and eosin (H&E) staining is performed on PDX samples for routine assessment and, in principle, captures the complex interplay between tumor and stromal cells. Deep learning (DL)-based analysis of large human H&E image repositories has extracted inter-cellular and morphological signals correlated with disease phenotype and therapeutic response. Here, we present an extensive, pan-cancer repository of nearly 1,000 PDX and paired human progenitor H&E images. These images, curated from the PDXNet consortium, are associated with genomic and transcriptomic data, clinical metadata, pathological assessment of cell composition, and, in several cases, detailed pathological annotation of tumor, stroma, and necrotic regions. We demonstrate that DL can be applied to these images to classify tumor regions with an accuracy of 0.87. Further, we show that DL can predict xenograft-transplant lymphoproliferative disorder, the unintended outgrowth of human lymphocytes at the transplantation site, with an accuracy of 0.97. This repository enables PDX-specific investigations of cancer biology through histopathological analysis and contributes important model system data that expand on existing human histology repositories. We expect the PDXNet Image Repository to be valuable for controlled digital pathology analysis, both for the evaluation of technical issues such as stain normalization and for development of novel computational methods based on spatial behaviors within cancer tissues. Citation Format: Brian S. White, Xing Yi Woo, Soner Koc, Todd Sheridan, Steven B. Neuhauser, Shidan Wang, Yvonne A. Evrard, John David Landua, R Jay Mashl, Sherri R. Davies, Bingliang Fang, Maria Gabriela Raso, Kurt W. Evans, Matthew H. Bailey, Yeqing Chen, Min Xiao, Jill Rubinstein, Ali Foroughi pour, Lacey Elizabeth Dobrolecki, Maihi Fujita, Junya Fujimoto, Guanghua Xiao, Ryan C. Fields, Jacqueline L. Mudd, Xiaowei Xu, Melinda G. Hollingshead, Shahanawaz Jiwani, PDXNet consortium, Tiffany A. Wallace, Jeffrey A. Moscow, James H. Doroshow, Nicholas Mitsiades, Salma Kaochar, Chong-xian Pan, Moon S. Chen, Luis G. Carvajal-Carmona, Alana L. Welm, Bryan E. Welm, Ramaswamy Govindan, Shunqiang Li, Michael A. Davies, Jack A. Roth, Funda Meric-Bernstam, Yang Xie, Meenhard Herlyn, Li Ding, Michael T. Lewis, Carol J. Bolt, Dennis A. Dean, Jeffrey H. Chuang. A pan-cancer PDX histology image repository with genomic and pathological annotations for deep learning analysis. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5407.
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Sitepu, B. P., and Ika Lestari. "PELAKSANAAN RENCANA PEMBELAJARAN SEMESTER DALAM PROSES PEMBELAJARAN DI PERGURUAN TINGGI." Perspektif Ilmu Pendidikan 32, no. 1 (April 30, 2018): 41–49. http://dx.doi.org/10.21009/pip.321.6.
Full textAbstract:
Higher-education curriculum is contained in Semester Learning Plan (RPS) as stated in Permenristekdikti No. 44 of 2015. RPS should bind lecturers and students into the contract of study/ college so that it needs to be supervised and examination of the quality of RPS made by lecturers. The purpose of this study is to conduct surveys and observations within the Fakultas Ilmu Pendidikan, Universitas Negeri Jakarta to obtain complete and accurate data and information. Referring to its purpose, this research includes descriptive evaluative research using qualitative and quantitative data. Data collection techniques used questionnaires, interviews, and document studies. Data is processed and analyzed using simple and descriptive statistics. The research was conducted in the Fakultas Ilmu Pendidikan, Universitas Negeri Jakarta in 2017. The results from the research are the percentage of lecturers to make RPS, student involvement in refining RPS, RPS utilization for students, students' knowledge on the subject and learning objectives during the course, and the references used. Further recommendations can be evaluated on the content of RPS made by lecturers in accordance with Permenristekdikti No. 44 of 2015.
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Peraturan pemerintah No 19 Tahun 2005
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Albrecht, Ken. "(Invited) Development of Highly Luminescent Radical Core Carbazole Dendrimer." ECS Meeting Abstracts MA2022-01, no. 13 (July 7, 2022): 895. http://dx.doi.org/10.1149/ma2022-0113895mtgabs.
Full textAbstract:
The development of emitting materials for OLEDs has started with fluorescence, moved to phosphorescence, and reached TADF. These materials have singlet ground state, but recently some ground state doublet (radical) emitting materials have been reported.1,2 The excited state of doublet emitters also has a doublet character, and theoretically, can achieve 100% exciton utilization efficiency in an OLED device. Triphenylmethyl radicals such as PTM (perchlorotriphenylmethyl) radical were recognized as emitters from the 1980s. The photostability of these radicals are extremely low, but in 2006 the introduction of donor (carbazole) unit was reported to improve the photostability and opened the door to utilize them as a luminescent materials.3 Carbazole dendrimers are widely used as solution-processable OLED material including TADF emitters.4 The dendron has a highly polarized unique electronic structure due to the summation of the inductive electron-withdrawing effect of carbazole units.5 The attachment of carbazole dendrons to luminescent radical is expected to increase the stability through the steric and electronic effects. A carbazole dendron (G2 to G4) attached TTM (tris(2,4,6-trichlorophenyl)-methyl) radicals were successfully synthesized and photophysical parameters were determined. All dendrimers showed red emission. PLQY (photoluminescence quantum yield) increased when the generation increased and reached 80%. The major reason was the decrease in the internal conversion rate (non-radiative decay). The photostability (PL intensity half-life measured under continuous laser irradiation) in solution has increased 100 to 1000 times compared to simple TTM radicals. These results indicate that the carbazole dendron attached TTM radicals are potential material for efficient OLEDs. References [1] Q. Peng, A. Obolda, M. Zhang, F. Li, Angew. Chem. Int. Ed. 2015, 54, 7091. [2] X. Ai, E. W. Evans, S. Dong, A. J. Gillett, H. Guo, Y. Chen, T. J. Hele, R. H. Friend, F. Li, Nature 2018, 563, 536. [3] V. Gamero, D. Velasco, S. Latorre, F. Lopez-Calahorra, E. Brillas, L. Julia, Tetrahedron Lett. 2006, 47, 2305. [4] K. Albrecht, K. Matsuoka, K. Fujita, K. Yamamoto, Angew. Chem. Int. Ed. 2015, 54, 5677. [5] K. Albrecht, K. Yamamoto J. Am. Chem. Soc. 2009, 131, 2244.
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Lloyd-Laney, Henry, Nicholas Yates, James Stapleton, Alice Hewson, Natalia Baranska, Alan Bond, David Gavaghan, and Alison Parkin. "Utilising Fourier Transform Voltammetry to Advance the Enzyme Electrochemistry Toolkit." ECS Meeting Abstracts MA2023-02, no. 52 (December 22, 2023): 2515. http://dx.doi.org/10.1149/ma2023-02522515mtgabs.
Full textAbstract:
Electron transfer and redox chemistry drives life and Biology can provide inspiration for the design of sustainable fuel catalysts that achieve highly active and selective small molecule transformations. In particular, the Parkin group are interested in hydrogenases,1 biological H2-producing enzymes, and lytic polysaccharide monooxygenases (LPMOs),2, 3 enzymes that breakdown cellulose. We seek to understand how the rate and energetics of electron transfer controls catalysis in such enzymes;4 to do this we collaborate with the Gavaghan and Bond groups to develop more powerful bioelectrochemical methodologies.5 This talk will describe our most recent efforts to integrate sinusoidal voltammetry into our enzyme-electrochemistry toolkit.6, 7 The technique offers advantages in terms of simulation speed, which in turn enables the powerful application of Bayesian statistical analysis to visualise the uncertainty in the modelling approach. However, we still rely on large amplitude Fourier transform voltammetry and direct current methodologies to visualise the Faradaic current and readily define redox reaction parameter bounds. References: [1] H. Adamson, M. Robinson, J. J. Wright, L. A. Flanagan, J. Walton, D. Elton, D. J. Gavaghan, A. M. Bond, M. M. Roessler and A. Parkin, J. Am. Chem. Soc., 2017, 139, 10677-10686. [2] P. J. Lindley, A. Parkin, G. J. Davies and P. H. Walton, Faraday Discuss., 2022, 234, 336-348. [3] J. Branch, B. S. Rajagopal, A. Paradisi, N. Yates, P. J. Lindley, J. Smith, K. Hollingsworth, W. B. Turnbull, B. Henrissat, A. Parkin, A. Berry and G. R. Hemsworth, Biochem. J., 2021, 478, 2927-2944. [4] A. R. Dale-Evans, M. J. Robinson, H. O. Lloyd-Laney, D. J. Gavaghan, A. M. Bond and A. Parkin, Front. Chemistry, 2021, 9. [5] H. Adamson, A. M. Bond and A. Parkin, Chem. Comm., 2017, 53, 9519-9533. [6] H. O. Lloyd-Laney, N. D. J. Yates, M. J. Robinson, A. R. Hewson, J. D. Firth, D. M. Elton, J. Zhang, A. M. Bond, A. Parkin and D. J. Gavaghan, Anal. Chem., 2021, 93, 2062-2071. [7] H. O. Lloyd-Laney, N. D. J. Yates, M. J. Robinson, A. R. Hewson, J. Branch, G. R. Hemsworth, A. M. Bond, A. Parkin and D. J. Gavaghan, Journal of Electroanalytical Chemistry, 2023, 935, 117264.
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Wirawan, Tri Cahyo Utomo, and Ari Hadi Prasetyo. "FAKTOR DETERMINAN KUALITAS AUDIT PADA KANTOR AKUNTAN PUBLIK DI DKI JAKARTA." Jurnal Akuntansi 10, no. 2 (August 31, 2021): 75–89. http://dx.doi.org/10.46806/ja.v10i2.800.
Full textAbstract:
The probability of an auditor found and reported a mistatement or an error due to fraud that occurs in a client's accounting system in perform the task called as audit quality. This study aims to determine the effect of competency, independency, professionalism, audit tenure and audit delay on audit quality. The research object consist of auditors who work in an active Public Accounting Firm (KAP) located in the DKI Jakarta area. The sampling technique used purposive sampling technique, obtained 85 auditor respondents from 12 active Public Accounting Firms listed in the KAP database published by the Ministry of Finance of the Republic of Indonesia in the DKI Jakarta area. The data analysis technique used is descriptive statistical analysis, data quality test, classical assumption test and hypothesis testing using SPSS Statistics 22. The results of the study conclude that there is sufficient evidence that the variables of competency, independency, professionalism and audit tenure have significant positive effect on audit quality. On the other hand, there is not enough evidence that the audit delay variable has a significant negative effect on audit quality.
Keywords: Competency, Independency, Professionalism, Audit Tenure, Audit Delay, Audit Quality.
References:
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Nuryani, Nunung. "PENGARUH BIAYA AUDIT TERHADAP KUALITAS AUDIT DAN DETERMINAN BIAYA AUDIT." Jurnal Akuntansi 9, no. 2 (August 15, 2020): 32–47. http://dx.doi.org/10.46806/ja.v9i2.760.
Full textAbstract:
Financial information is one of the important information in decision making. However, many cases of fraud committed by management so that the information in the financial statements cannot be relied upon in decision making. Therefore, the auditor's job is to ensure that the company's financial statements are represented correctly (faithful representation) so that financial statement information becomes more quality and useful in making decisions. So this study aims to examine the effect of audit fee on audit quality. In addition, this study also examines important determinants of audit costs, namely company size, profitability, audit risk, complexity, and firm size. By using the purposive sampling method, samples of the financial and manufacturing industry in 2010-2017 used are 39 firms per year. This sample is used to examine the effect of audit fee on audit quality and the determinant of audit fee using simple linear regression analysis and multiple linear regression analysis. The result of this research shows that audit fees have a significant positive effect on audit quality. In addition, this study shows that firm size, complexity, and firm size are important determinants that determine audit fee. However, profitability and audit risk have not been proven to explain audit fees.
Keywords: Audit Quality, Audit Fee, Firm Size, Profitability, Audit Risk, Complexity, Auditor Size
Referencens:
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Smith, J. A., T. J. Dreaden, A. E. Mayfield, A. Boone, S. W. Fraedrich, and C. Bates. "First Report of Laurel Wilt Disease Caused by Raffaelea lauricola on Sassafras in Florida and South Carolina." Plant Disease 93, no. 10 (October 2009): 1079. http://dx.doi.org/10.1094/pdis-93-10-1079b.
Full textAbstract:
Laurel wilt disease, caused by Raffaelea lauricola (T.C. Harr., Fraedrich & Aghayeva sp. nov.), which is a fungal symbiont of the nonnative redbay ambrosia beetle (Xyleborus glabratus Eichhoff), has caused widespread mortality of native redbay (Persea borbonia (L.) Spreng) in Georgia, South Carolina, and Florida since 2002. The disease has been noted on other species in the Lauraceae including sassafras in Georgia (1), and more recently, on avocado and camphor in Florida (4). Since 2005, wilted shoots, branch dieback, and tree death have been observed in sassafras trees (Sassafras albidum (L.)) in Liberty, McIntosh, Chatham, Effingham, Bulloch, Evans, and Screven counties in Georgia; Bamberg, Beaufort, Charleston, Colleton, Hampton, and Orangeburg counties in South Carolina; and Putnam County in Florida. Symptomatic sassafras trees ranged from 1 to 12 m high and 2.5 to 25 cm in diameter at breast height. In contrast to red bay trees that retain wilted foliage, symptomatic sassafras defoliate rapidly as trees wilt and die. Multiple symptomatic ramets originating from a common root system have been observed. Removal of bark from stem and root sections from wilted trees revealed black-to-brownish staining in the sapwood, characteristic of laurel wilt. Wood chips from symptomatic areas of branches and roots were surface sterilized and plated on cycloheximide-streptomycin malt agar as previously described (1) and R. lauricola was routinely isolated. Small subunit (18S) sequences from rDNA were amplified by PCR and sequenced using primers NS1 and NS4 (3) for isolates from sassafras from Florida and South Carolina. BLASTn searches revealed homology to Raffaelea sp. C2203 (GenBank Accession No. EU123076, 100% similarity) described by Fraedrich et al. (1) from redbay and later named R. lauricola (2). The small subunit rDNA sequences for these isolates have been deposited into GenBank ( http://www.ncbi.nlm.nih.gov/Genbank/index.html ) and assigned Accession Nos. EU980448 (Florida) and GQ329704 (South Carolina). Koch's postulates have been completed with R. lauricola on this host previously (1). Laurel wilt on sassafras often was geographically isolated from other symptomatic hosts in Georgia and South Carolina and appears to occur on this host independently of proximity to redbay. Further studies to determine the epidemiology of laurel wilt on sassafras, potential resistance, and impact on sassafras life history and distribution are needed. Given the clonal nature of sassafras, the disease would appear to have the potential to move through roots of trees once established in a stand. References: (1) S. W Fraedrich et al. Plant Dis. 92:215, 2008. (2) T. C. Harrington et al. Mycotaxon 104:399, 2008. (3) M. A. Innis et al. PCR Protocols, A Guide to Methods and Applications. Academic Press, San Diego, CA, 1990. (4) J. A. Smith et al. Plant Dis. 93:198, 2009.
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Dillon, S. R., K. E. Lewis, S. Mudri, K. Kleist, L. Griffin, L. S. Evans, J. Bhandari, et al. "POS0094 ALPN-303, AN ENGINEERED DUAL BAFF/APRIL ANTAGONIST, POTENTLY INHIBITS PATHOGENIC LYMPHOCYTE SUBSETS AND FUNCTION IN B-CELL- AND ANTIBODY-RELATED PRECLINICAL MODELS." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 268.2–269. http://dx.doi.org/10.1136/annrheumdis-2022-eular.771.
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BackgroundB-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are tumor necrosis factor (TNF) superfamily members that bind TACI (transmembrane activator and CAML interactor), BCMA (B-cell maturation antigen), and/or BAFF-R on B cells and together support B cell development, differentiation, and survival. ALPN-303 is an Fc fusion protein of a human TACI variant TNFR domain engineered by directed evolution1,2. It mediates significantly improved combined BAFF and APRIL inhibition in vitro and enhanced pharmacokinetic and immunomodulatory properties in preclinical studies, as compared to wild-type (WT) TACI-Fc molecules. B-cell targeting therapies like the WT TACI-Fc fusions atacicept and telitacicept have demonstrated promising clinical potential in B cell-related diseases like systemic lupus erythematosus (SLE). ALPN-303, with enhanced inhibitory activity against BAFF and APRIL, has previously been shown to demonstrate promising efficacy in an (NZB/NZW)F1 mouse model of lupus, and may therefore further improve clinical outcomes in such diseases.ObjectivesTo further characterize the comparative activity of ALPN-303 versus an Fc matched control, a WT TACI-Fc comparator (telitacicept), and/or a B cell-depleting therapy (anti-mouse CD20 [anti-mCD20] monoclonal antibody [mAb]), in antibody-related preclinical models.MethodsThe functional activity of ALPN-303, as compared to telitacicept or a depleting anti-mCD20 mAb, was evaluated in a sheep red blood cell (SRBC) immunization mouse model. Mice immunized intraperitoneally with SRBC on Study Day 0 were administered 200 µg ALPN-303 or a molar-matched amount (240 µg) of telitacicept on Days 1 and 6 or were treated with 200 µg anti-mCD20 (rat IgG2b) on Day 1. At study termination on Day 15, serum was collected to measure levels of test article and anti-SRBC immunoglobulin (Ig) titers, and spleens and bone marrow (BM) were collected for immunophenotyping by flow cytometry. A study in the inducible bm12 mouse model of lupus was also conducted, with mice treated twice weekly with 200 µg ALPN-303 or a molar-matched dose of Fc control, starting on Day 5 after splenocyte transfer and continuing through Week 13.ResultsALPN-303 administration rapidly and potently reduced BM plasma cells, splenic germinal center B cells, follicular T helper cells, and plasmablasts in SRBC-immunized mice, often significantly more so than telitacicept and/or anti-mCD20 mAb. ALPN-303 also significantly reduced serum titers of anti-SRBC IgM, IgG1, IgG2a, and IgG2b as compared to all other treatment groups. In the bm12 model, ALPN-303 treatment significantly impacted the same key lymphocyte subsets affected in the SRBC model, and significantly reduced circulating anti-dsDNA antibodies (Figure 1) and total IgA, IgM, IgG1, IgG2b, and IgG3, and inhibited renal IgG deposits (Figure 1).Figure 1.ALPN-303 treatment significantly reduces serum autoantibody titers and renal immune complex deposition in the inducible bm12 mouse model of lupus. *p<0.05, **p<0.01, ****p<0.0001 by the Kruskal-Wallis test.ConclusionALPN-303 is an engineered, potent BAFF/APRIL antagonist that continues to consistently demonstrate encouraging immunomodulatory activity and efficacy in vitro and in vivo, as further demonstrated in the SRBC immunization and bm12 lupus models, with superiority to WT TACI-Fc and anti-CD20 comparators. ALPN-303 may thus be an attractive development candidate for the treatment of multiple autoimmune and inflammatory diseases, particularly B cell- and/or autoantibody-related diseases such as SLE, Sjögren’s syndrome, and other connective tissue diseases. A Phase 1 study of ALPN-303 in adult healthy volunteers (NCT05034484) is ongoing.References[1]Dillon SR, Evans LS, Lewis KE, et al. Annals of the Rheumatic Diseases 2021;80:21.[2]Dillon SR, Evans LS, Lewis KE, et al. Arthritis Rheumatol. 2021; 73 (suppl 10).Disclosure of InterestsStacey R. Dillon Employee of: Alpine Immune Sciences, Katherine E. Lewis Employee of: Alpine Immune Sciences Inc, Sherri Mudri Employee of: Alpine Immune Sciences Inc, Kayla Kleist Employee of: Alpine Immune Sciences Inc, Luana Griffin Employee of: Alpine Immune Sciences Inc, Lawrence S. Evans Employee of: Alpine Immune Sciences Inc, Janhavi Bhandari Shareholder of: Amgen, Novo Nordisk, Employee of: Alpine Immune Sciences Inc, Logan Garrett Employee of: Alpine Immune Sciences Inc, Michelle A. Seaberg Employee of: Alpine Immune Sciences Inc, NingXin Wang Employee of: Alpine Immune Sciences Inc, Allison Chunyk Employee of: Alpine Immune Sciences Inc, Daniel Ardourel Employee of: Alpine Immune Sciences Inc, LuAnne Hebb Employee of: Alpine Immune Sciences Inc, Martin F. Wolfson Employee of: Alpine Immune Sciences Inc, Mark W. Rixon Employee of: Alpine Immune Sciences Inc, Pamela Holland Employee of: Alpine Immune Sciences Inc, Stanford L. Peng Employee of: Alpine Immune Sciences Inc
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Koltun, Elena S., Meghan A. Rice, W. Clay Gustafson, David Wilds, Jingjing Jiang, Bianca J. Lee, Zhengping Wang, et al. "Abstract 3597: Direct targeting of KRASG12X mutant cancers with RMC-6236, a first-in-class, RAS-selective, orally bioavailable, tri-complex RASMULTI(ON) inhibitor." Cancer Research 82, no. 12_Supplement (June 15, 2022): 3597. http://dx.doi.org/10.1158/1538-7445.am2022-3597.
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Abstract Mutant RAS is common in pancreatic carcinoma (PDAC), non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) and exists predominantly in the GTP-bound (RAS(ON)) state, leading to excessive downstream oncogenic signaling. KRASG12C(OFF) inhibitors have provided clinical proof of concept for targeting mutant KRAS. Preclinical data suggests inhibition of RAS(ON) may be a superior therapeutic strategy. In addition, KRASG12 mutations such as KRASG12D and KRASG12V remain unserved.RMC-6236 is a first-in-class, potent, oral tri-complex RASMULTI(ON) small molecule inhibitor designed to treat cancers driven by a variety of RAS mutations. RMC-6236 non-covalently binds to an abundant intracellular chaperone protein, cyclophilin A (CypA), resulting in a binary complex that engages RAS(ON) to form a high-affinity, RAS-selective tri-complex that sterically inhibits RAS binding to effectors. Exposure to RMC-6236 suppressed ERK phosphorylation and cell growth, and induced apoptosis in multiple human RAS-addicted cancer cell lines in vitro.RMC-6236 induced dose-dependent, deep, and durable suppression of RAS pathway activation up to 48 hours in preclinical xenograft models in vivo. Prolonged exposure in tumors was observed relative to blood and various healthy tissues, likely mediated by high affinity binding of RMC-6236 to tumor CypA.RMC-6236 at tolerable doses induced profound and durable tumor regressions in multiple cell line-derived (CDX) and patient-derived (PDX) RASMUT xenograft models, including NSCLC, CRC and PDAC. Anti-tumor activity was particularly notable in KRAS position 12 (G12X) mutant tumors, particularly KRASG12D, KRASG12V, and KRASG12R, with significant tumor regressions observed. Tumor growth inhibition was durable even in tumors that did not regress. Intermittent scheduling of RMC-6236 was active and permitted a higher dose intensity than daily dosing.RMC-6236 promoted anti-tumor immunity in vivo and was additive with anti-PD1 antibodies, driving durable complete responses and immunologic memory in a KRAS mutant CRC model. Furthermore, RMC-6236 treatment reversed oncogenic RAS-driven immune evasion mechanisms in a checkpoint blockade refractory KRAS mutant model, significantly transforming the tumor microenvironment in favor of anti-tumor immunity.These preclinical results support the inclusion of NSCLC, PDAC, and CRC patients in our planned clinical trial of RMC-6236 in patients with KRASG12X advanced solid tumors. Citation Format: Elena S. Koltun, Meghan A. Rice, W. Clay Gustafson, David Wilds, Jingjing Jiang, Bianca J. Lee, Zhengping Wang, Stephanie Chang, Mike Flagella, Yunming Mu, Nuntana Dinglasan, Nicole Nasholm, James W. Evans, Yingyun Wang, Kyle Seamon, Yang Liu, Cristina Blaj, John Knox, Rebecca Freilich, Elsa Quintana, Jim Cregg, Alun Bermingham, Adrian L. Gill, Jacqueline Am Smith, Mallika Singh. Direct targeting of KRASG12X mutant cancers with RMC-6236, a first-in-class, RAS-selective, orally bioavailable, tri-complex RASMULTI(ON) inhibitor [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 3597.
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Hughes, T. J., David Langridge, J. P. Haughton, James E. Killen, A. A. Horner, D. McCourt, E. M. Fahy, et al. "Reviews of Books." Irish Geography 6, no. 4 (December 30, 2016): 502–14. http://dx.doi.org/10.55650/igj.1972.947.
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MAN AND HIS HABITAT. ESSAYS PRESENTED TO EMYR ESTYN EVANS, edited by R. H. Buchanan, Emrys Jones and Desmond McCourt. London: Routledge and Kegan Paul, 1971. xi + 279 pp. £5.50.A SYSTEMATIC GEOGRAPHY OF IRELAND, by Desmond Gillmor. Dublin: Gill and MacMillan, 1971. 214 pp. £1.05.L'IRLANDE. 1, MILIEU ET HISTOJRE, by J. Guiffan, J. Verrière and P. Rafroidi. Paris: Armand Colin, 1970. 320 pp.AIR TEMPERATURE IN IRELAND, 1931–1960. Dublin: Department of Transport and Power, Meteorological Service, 1971. 68 pp. 35p.MONTHLY, SEASONAL AND ANNUAL, MEAN AND EXTREME VALUES OF DURATION OF BRIGHT SUNSHINE IN IRELAND, 1931–1960. Dublin: Department of Transport and Power, Meteorological Service, 1971. 26 pp. 15p.THE APPLICATION OF GEOGRAPHICAL TECHNIQUES TO PHYSICAL PLANNING. Dublin: An Foras Forbartha, 1971. 163 pp. £2.00.AN TSUIRBHEIREACHT AR GHAELTACHT NA GAILLIMHE/THE GALWAY GAELTACHT SURVEY. Galway: University College, Social Sciences Research Centre, 1969. Volume 1, 81 pp. Volume 2, 44 figures.TRANSPORTATION IN DUBLIN. Dublin: An Foras Forbartha (The National Institute for Physical Planning and Construction Research), No Date. 48 pp. £1.THE CORK SUB‐REGIONAL PLANNING STUDY, by F. B. Gillie. Dublin: An Foras Forbartha, 1971. 125 pp. £1.50.CORK: AN ENVIRONMENTAL STUDY OF CORK, by Peter Dovell. Dublin: An Foras Forbartha, 1971. 42 pp. 50p.THE SPADE IN NORTHERN AND ATLANTIC EUROPE, edited by Alan Gailey and Alexander Fenton. Belfast: Ulster Folk Museum and Institute of Irish Studies, 1970. xiii + 257 pp. £1.65.DESERTED MEDIEVAL VILLAGES, edited by Maurice Beresford and John G. Hurst. London: Lutterworth Press, 1971. 340 pp. £8.00.REGIONAL ARCHAEOLOGIES: ULSTER, by L. N. W. Flanagan. London: Heinemann Educational Books, 1970. 56 pp. 90p.IRISH PASSENGER STEAMSHIP SERVICES. Volume 2: SOUTH OF IRELAND, by D. B. McNeill. Newton Abbot: David and Charles, 1971. 240 pp. £2.50.THREE HUNDRED YEARS OF IRISH PRINTED MAPS. Belfast: Ulster Museum, 1972. 32 pp.JOURNAL OF THE KERRY ARCHAEOLOGICAL AND HISTORICAL SOCIETY, No. 4, 1971. 194 pp. Not on public sale.JOURNAL OF THE OLD ATHLONE SOCIETY, Vol. 1, No. 2, 1970–71. 76 pp. 75p.GEOLOGY OF BELFAST AND THE LAGAN VALLEY, by P. I. Manning, J. A. Robbie and H. E. Wilson. H.M. Stationery Office, 1970. 242 pp. £2.MAP REVIEWGEOLOGY OF NORTHERN IRELAND, Sheet 36 (Belfast). 1:63,360. 1966GEOLOGY OF BELFAST AND DISTRICT. 1:21,120. 1971. Both published by the Ordnance Survey, Southampton, for the Institute of Geological Sciences.
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Hubisz, John L. "Legal Alchemy: The Use and Misuse of Science in the Law, by David L. Faigman, Galileo’s Revenge: Junk Science in the Courtroom, by Peter W. Huber, and The Casebook of Forensic Detection: How Science Solved 100 of the World’s Most Baffling Crimes, by Colin Evans." Physics Teacher 38, no. 1 (January 2000): 57. http://dx.doi.org/10.1119/1.880433.
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Marcelino, Juan, and Mulyani. "UKURAN PERUSAHAAN MEMODERASI PENGARUH PROFITABILITAS DAN SOLVABILITAS TERHADAP AUDIT DELAY." Jurnal Akuntansi 10, no. 2 (August 31, 2021): 98–113. http://dx.doi.org/10.46806/ja.v10i2.802.
Full textAbstract:
Audit delay is the length of time required by the company in completing the audit of the financial statements. This delay can affect the level of decision uncertainty from investors. However, there are still many go-public companies that are late in submitting their audited financial reports. The theories used are agency theory, signal theory and compliance theory. The sampling technique was determined based on the purposive sampling method so as to produce a total sample of 44 companies and obtained a total of 132 observations. The data analysis techniques used in this study were pooling test, descriptive statistical test, classical assumption test, multiple linear regression test, moderated regression test. Analysis, F test, t test, and coefficient of determination test. The t test results show that solvency has a significance value greater than 0.05, profitability, firm size, the interaction between profitability and firm size, and the interaction between solvency and firm size have a significance less than 0.05. The conclusion of this study shows that there is sufficient evidence of profitability, firm size, the interaction between profitability and firm size and the interaction between solvency and firm size has a negative effect on audit delay and there is insufficient evidence that solvency has a positive effect on audit delay.
Keywords: Profitability, Solvability, Firm Size, Audit Delay.
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Sri Wahyuni, Siti Fadilah, and Adolf Bastian. "Children's independence Skills Analysis at Low Socioeconomic Environment." JPUD - Jurnal Pendidikan Usia Dini 14, no. 2 (November 30, 2020): 303–12. http://dx.doi.org/10.21009/jpud.142.08.
Full textAbstract:
Research suggests that child independence is more popular in countries with greater wealth and a higher percentage of the educated population. Various research implications expect children's independence and compliance to increase over time in developing countries. This study aims to describe the independence of early childhood who comes from low-income families or at low socioeconomic environment. Using quantitative descriptive, data collection techniques are carried out through a questionnaire. The study population was 30 respondents from the ECE institution who were included in the list of low-income families in 2018, using an area sampling technique. Overall, the teacher stated that all indicators of dependence on children from low-income families had reached the high category, which was 75%. The implication of further research is that aspects of independence in physical abilities, self-confidence, responsibility, discipline, sociability, sharing, and independence in terms of emotional control in early childhood can develop better in a low socio-economic environment.
Keywords: Early Childhood, Independence skills, low-socioeconomic environment
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