Relevant bibliographies by topics / Vocal fold healing

Academic literature on the topic 'Vocal fold healing'

Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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Journal articles on the topic "Vocal fold healing"

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Branski, Ryan C. "Perioperative Voice Recovery: A Wound-Healing Perspective." Perspectives on Voice and Voice Disorders 23, no. 2 (July 2013): 42–46. http://dx.doi.org/10.1044/vvd23.2.42.

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To describe the wound healing process through an oversimplified graphic, a classic cartoon in a Dermatology Clinics textbook shows a Volkswagen Beetle, with the license plate TRAUMA that has driven through a wooden fence, leaving both a substantive hole in the fence and piles of broken wooden planks. The obvious priority would be to rebuild the fence so that it is identical to its pretrauma state. This analogy and accompanying graphic provide a framework for a unique perspective on wound healing. For the sake of simplicity, let us assume that the vocal fold is a fence, and instead of a Volkswagen Beetle, the trauma is surgical excision of a vocal fold lesion. Immediately following surgery, the human body initiates the process of rebuilding vocal fold tissue. From a physiological perspective, it would be ideal to regain the original architecture of the vocal fold to ensure minimal alteration to phonatory physiology. Unfortunately, beyond the 2nd trimester of gestation, wounds heal with subsequent scarring. In the vocal folds, this scarring can have significant deleterious effects on vocal fold pliability and lead to dysphonia. However, investigators have shown that wounds heal regeneratively (i.e., no scarring) in the fetal environment. This observation provides potential targets for therapies to direct wound healing toward a more favorable outcome. In this article, I provide a brief overview of the biochemical processes associated with wound healing. Subsequently, I outline the underlying rationale for tissue mobilization in the context of acute vocal fold injury.
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Carissa, Portone-Maira, and M. Johns Michael. "Perioperative Voice Recovery and the Vocal Folds: Perspectives From the Voice Care Team." Perspectives on Voice and Voice Disorders 23, no. 2 (July 2013): 53–60. http://dx.doi.org/10.1044/vvd23.2.53.

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Information regarding the significance of wound healing in laryngology is steadily increasing. Vocal fold tissue may be injured by phonotrauma (excessive impact from the opposing vocal fold), chemical agents (e.g., stomach acid), trauma, or iatrogenic causes (i.e., intubation, vocal fold surgery). Following injury, the affected area becomes inflamed. The body initiates cell proliferation and matrix deposition to begin the process of healing. Matrix remodeling during the healing process determines the degree of scar formation. Vocal fold scar has well-documented structural and functional consequences, and is notoriously difficult to manage (Hirano, 2005). Our roles as vocal professionals in relationship to the stages of wound healing change at key time points: before creating a wound, when making a wound, acute management (0–2 weeks), subacute management (2–8 weeks), and late management (8 weeks and beyond)..
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Cohen, Seth M., C. Gaelyn Garrett, Shan Huang, and Mark S. Courey. "Acute Histologic Effects of Extraesophageal Reflux on Vocal Fold Healing." Annals of Otology, Rhinology & Laryngology 114, no. 4 (April 2005): 296–303. http://dx.doi.org/10.1177/000348940511400408.

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This study evaluates how extraesophageal reflux affects membranous vocal fold healing in a canine model. We created membranous vocal fold injuries in the animals and randomly assigned them to topical application of acid and pepsin at pH 2 or pH 6 or of normal saline solution every other day for 12 days. The experimental vocal folds were compared to uninjured, control vocal folds from animals painlessly sacrificed for other reasons. Hematoxylin and eosin, fibronectin, and procollagen I staining were performed for histologic analysis. The injured specimens had three times greater cellular infiltrate (p ≤ .001, analysis of variance) and twice as much fibronectin and procollagen I (p ≤ .001, analysis of variance) as did the specimens from the control animals. No significant differences or trends were identified for cellular infiltrate, fibronectin, or procollagen I within the injured groups (p > .05, Bonferroni t-test). Acute wound healing did not appear to be influenced by the presence of acid and pepsin at pH 2 or 6 as compared to saline solution.
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Hirano, Shigeru, Susan Thibeault, Charles N. Ford, Diane M. Bless, and Shin-Ichi Kanemaru. "Hepatocyte Growth Factor and its Receptor C-Met in Rat and Rabbit Vocal Folds." Annals of Otology, Rhinology & Laryngology 111, no. 8 (August 2002): 661–66. http://dx.doi.org/10.1177/000348940211100801.

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Vocal fold fibrotic scar is characterized by fibrosis of the lamina propria and epithelium, and is difficult to treat. Hepatocyte growth factor (HGF) has antifibrotic activity and has received attention as a possible therapeutic alternative to treat fibrosis. In this study, in order to clarify whether HGF can be involved in vocal fold scarring, we examined the existence of HGF and its receptor, c-Met, in rat vocal folds, and then the activity of HGF in rabbit injured vocal folds, using immunohistochemistry and enzyme-linked immunosorbent assay. We found HGF and c-Met on epithelial cells and gland cells of the rat vocal folds. On the injured vocal folds of rabbits, little HGF was observed immediately after injury, but prominent activity occurred simultaneously with reepithelialization of the vocal fold mucosa on days 10 to 15. The activity of HGF was observed on fibroblasts in the lamina propria, as well as the epithelium. It is suggested that HGF in the vocal folds is produced by the fibroblasts and delivered to the epithelium. The implication of these findings is that HGF is involved in wound healing of the vocal fold, and may provide an alternative approach in preventing and treating vocal fold scarring.
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Novaleski, Carolyn K., Bruce D. Carter, M. Preeti Sivasankar, Sheila H. Ridner, Mary S. Dietrich, and Bernard Rousseau. "Apoptosis and Vocal Fold Disease: Clinically Relevant Implications of Epithelial Cell Death." Journal of Speech, Language, and Hearing Research 60, no. 5 (May 24, 2017): 1264–72. http://dx.doi.org/10.1044/2016_jslhr-s-16-0326.

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Purpose Vocal fold diseases affecting the epithelium have a detrimental impact on vocal function. This review article provides an overview of apoptosis, the most commonly studied type of programmed cell death. Because apoptosis can damage epithelial cells, this article examines the implications of apoptosis on diseases affecting the vocal fold cover. Method A review of the extant literature was performed. We summarized the topics of epithelial tissue properties and apoptotic cell death, described what is currently understood about apoptosis in the vocal fold, and proposed several possible explanations for how the role of abnormal apoptosis during wound healing may be involved in vocal pathology. Results and Conclusions Apoptosis plays an important role in maintaining normal epithelial tissue function. The biological mechanisms responsible for vocal fold diseases of epithelial origin are only beginning to emerge. This article discusses speculations to explain the potential role of deficient versus excessive rates of apoptosis and how disorganized apoptosis may contribute to the development of common diseases of the vocal folds.
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Kim, Choung-Soo, Hyunsu Choi, Ki Cheol Park, Sung Won Kim, and Dong-Il Sun. "The Ability of Human Nasal Inferior Turbinate–Derived Mesenchymal Stem Cells to Repair Vocal Fold Injuries." Otolaryngology–Head and Neck Surgery 159, no. 2 (March 20, 2018): 335–42. http://dx.doi.org/10.1177/0194599818764627.

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Objective This study investigated the ability of implanted human nasal inferior turbinate–derived mesenchymal stem cells (hTMSCs) to repair injured vocal folds. To this end, we used quantitative real-time polymerase chain reaction (PCR) to analyze the early phase of wound healing and histopathological analysis to explore the late phase of wound healing in xenograft animal models. Study Design Prospective animal study. Setting Research laboratory. Subjects and Methods The right-side lamina propria of the vocal fold was injured in 20 rabbits and 30 rats. Next, hTMSCs were implanted into half of the injured vocal folds (hTMSC groups). As a control, phosphate-buffered saline (PBS) was injected into the other half of the injured vocal folds (PBS groups). Rat vocal folds were harvested for polymerase chain reaction (PCR) at 1 week after injury. Rabbit vocal folds were evaluated endoscopically and the larynges harvested for histological and immunohistochemical examination at 2 and 8 weeks after injury. Results In the hTMSC group, PCR showed that hyaluronan synthase ( HAS) 1, HAS 2, and transforming growth factor ( TGF)–β1 were significantly upregulated compared with the PBS group. Procollagen type III ( COL III) messenger RNA expression was significantly upregulated in the PBS group compared with the normal group. Histological analyses showed that hTMSC administration afforded more favorable collagen and hyaluronic acid deposition than was evident in the controls. Implanted hTMSCs were observed in injured vocal folds 2 weeks after implantation. Conclusions Our results show that hTMSCs implantation into injured vocal folds facilitated vocal fold regeneration, with presenting antifibrotic effects.
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Goel, Alexander N., Bhavani S. Gowda, Mysore S. Veena, Travis L. Shiba, and Jennifer L. Long. "Adipose-Derived Mesenchymal Stromal Cells Persist in Tissue-Engineered Vocal Fold Replacement in Rabbits." Annals of Otology, Rhinology & Laryngology 127, no. 12 (October 8, 2018): 962–68. http://dx.doi.org/10.1177/0003489418806008.

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Objectives: Cell therapies using mesenchymal stromal cells (MSCs) have been proposed as a promising new tool for the treatment of vocal fold scarring. However, the mechanisms by which MSCs promote healing as well as their duration of survival within the host vocal fold have yet to be defined. The aim of this work was to assess the persistence of embedded MSCs within a tissue-engineered vocal fold mucosal replacement in a rabbit model of vocal fold injury. Methods: Male rabbit adipose-derived MSCs were embedded within a 3-dimensional fibrin gel, forming the cell-based outer vocal fold replacement. Four female rabbits underwent unilateral resection of vocal fold epithelium and lamina propria and reconstruction with cell-based outer vocal fold replacement implantation. Polymerase chain reaction and fluorescent in situ hybridization for the sex-determining region of the Y chromosome (SRY-II) in the sex-mismatched donor-recipient pairs sought persistent cells after 4 weeks. Results: A subset of implanted male cells was detected in the implant site at 4 weeks. Many SRY-II-negative cells were also detected at the implant site, presumably representing native female cells that migrated to the area. No SRY-II signal was detected in contralateral control vocal folds. Conclusions: The emergent tissue after implantation of a tissue-engineered outer vocal fold replacement is derived both from initially embedded adipose-derived stromal cells and infiltrating native cells. Our results suggest this tissue-engineering approach can provide a well-integrated tissue graft with prolonged cell activity for repair of severe vocal fold scars.
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Branski, Ryan C., Katherine Verdolini, Vlad Sandulache, Clark A. Rosen, and Patricia A. Hebda. "Vocal Fold Wound Healing: A Review for Clinicians." Journal of Voice 20, no. 3 (September 2006): 432–42. http://dx.doi.org/10.1016/j.jvoice.2005.08.005.

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Gaston, Joel, and Susan L. Thibeault. "Hyaluronic acid hydrogels for vocal fold wound healing." Biomatter 3, no. 1 (January 2013): e23799. http://dx.doi.org/10.4161/biom.23799.

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Dion, Gregory R., Teja Guda, Shigeyuki Mukudai, Renjie Bing, Jean‐Francois Lavoie, and Ryan C. Branski. "Quantifying vocal fold wound‐healing biomechanical property changes." Laryngoscope 130, no. 2 (May 6, 2019): 454–59. http://dx.doi.org/10.1002/lary.27999.

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Dissertations / Theses on the topic "Vocal fold healing"

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Mizuta, Masanobu. "Effect of the Regulation of Oxidative Stress on Vocal Fold Wound Healing/ Expression of reactive oxygen species during wound healing of vocal folds in a rat model." Doctoral thesis, Kyoto University, 2015. http://hdl.handle.net/2433/199160.

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京都大学
0048
新制・課程博士
博士(医学)
甲第18851号
医博第3962号
新制||医||1007(附属図書館)
31802
京都大学大学院医学研究科医学専攻
(主査)教授 別所 和久, 教授 鈴木 茂彦, 教授 瀬原 淳子
学位規則第4条第1項該当
Doctor of Medical Science
Kyoto University
DFAM
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2

Mizuta, Masanobu. "Effect of the Regulation of Oxidative Stress on Vocal Fold Wound Healing / Expression of reactive oxygen species during wound healing of vocal folds in a rat model." Kyoto University, 2003. http://hdl.handle.net/2433/199160.

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3

Hiwatashi, Nao. "The efficacy of a novel collagen-gelatin scaffold with basic fibroblast growth factor for the treatment of vocal fold scar." Kyoto University, 2016. http://hdl.handle.net/2433/215428.

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Final publication is available at http://onlinelibrary.wiley.com/doi/10.1002/term.2060/abstract;jsessionid=F0849D98381EEF9E83401A02B9042F4D.f04t02
Kyoto University (京都大学)
0048
新制・課程博士
博士(医学)
甲第19602号
医博第4109号
新制||医||1014(附属図書館)
32638
京都大学大学院医学研究科医学専攻
(主査)教授 別所 和久, 教授 伊佐 正, 教授 川口 義弥
学位規則第4条第1項該当
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Books on the topic "Vocal fold healing"

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Ryan, C. Ph D. Branski, Shigeru Hirano, and Ph D. Verdolini Katherine. Vocal Fold Wound Healing: From Basic Science to Clinical Care. Plural Publishing, 2008.

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Conference papers on the topic "Vocal fold healing"

1

Li, Yun (Yvonna), Yee Key (Nicole) Li, Alireza Najafi Yazdi, and Luc Mongeau. "Implementation of Agent Based Model of Tissue Inflammation on a Graphics Processing Unit Platform." In ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fmd2013-16131.

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Scarring of the vocal folds is commonly caused by surgical injury or high impact voice use. As the by-product of the tissue healing in response to the injury, scarring involves a plethora of cells and chemicals whose interactions are dynamic and non-linear (Li et al, 2011). A thorough understanding of the wound healing process is needed. The ability to model cellular interactions using computer simulations constitutes the first step towards patient specific treatments of vocal fold injuries.
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Seekhao, Nuttiiya, Caroline Shung, Joseph Jaja, Luc Mongeau, and Nicole Y. K. Li-Jessen. "Real-Time Agent-Based Modeling Simulation with in-Situ Visualization of Complex Biological Systems: A Case Study on Vocal Fold Inflammation and Healing." In 2016 IEEE International Parallel and Distributed Processing Symposium Workshops (IPDPSW). IEEE, 2016. http://dx.doi.org/10.1109/ipdpsw.2016.20.

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Bhattacharya, Pinaki, and Thomas H. Siegmund. "Determination of Mechanical Stresses in Vibration and Contact During Flow-Structure-Interaction in Vocal Folds." In ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53849.

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Mechanical stresses in vocal folds (VFs) developed during self-oscillation — due to interaction with the glottal flow — play an important role in tissue damage and healing. Contact stresses occurring due to collision between VFs modify both self-oscillation characteristics, as well as stresses. The complexity of the problem is increased due to other factors acting in combination: transient nature of the flow, non-linear and anisotropic biomechanical properties of the VFs, and acoustic loading. Experiments with physical models [1] have attempted to deduce the state of stress in the interior through measurement of superior surface deformation. However, these methods pose challenges in data acquisition. on the other hand, full three-dimensional transient computational analysis of a self-oscillating and contacting VF model requires highly sophisticated algorithms as well as prohibitive resource usage. Not surprisingly, therefore, it has not been conducted until now. We hypothesize that a high-fidelity numerical simulation incorporating realistic tissue properties is essential to accurately determine stresses within VFs during self-oscillation and contact.
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