Academic literature on the topic 'Vocal fold biology'

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Journal articles on the topic "Vocal fold biology"

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Lee, Jung-Won, Hong-Goo Kang, Jeung-Yoon Choi, and Young-Ik Son. "An Investigation of Vocal Tract Characteristics for Acoustic Discrimination of Pathological Voices." BioMed Research International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/758731.

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This paper investigates the effectiveness of measures related to vocal tract characteristics in classifying normal and pathological speech. Unlike conventional approaches that mainly focus on features related to the vocal source, vocal tract characteristics are examined to determine if interaction effects between vocal folds and the vocal tract can be used to detect pathological speech. Especially, this paper examines features related to formant frequencies to see if vocal tract characteristics are affected by the nature of the vocal fold-related pathology. To test this hypothesis, stationary fragments of vowel /aa/ produced by 223 normal subjects, 472 vocal fold polyp subjects, and 195 unilateral vocal cord paralysis subjects are analyzed. Based on the acoustic-articulatory relationships, phonation for pathological subjects is found to be associated with measures correlated with a raised tongue body or an advanced tongue root. Vocal tract-related features are also found to be statistically significant from the Kruskal-Wallis test in distinguishing normal and pathological speech. Classification results demonstrate that combining the formant measurements with vocal fold-related features results in improved performance in differentiating vocal pathologies including vocal polyps and unilateral vocal cord paralysis, which suggests that measures related to vocal tract characteristics may provide additional information in diagnosing vocal disorders.
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Won, Ho-Ryun, Eun Hye Song, Jong Eun Won, Hye Young Lee, Sung Un Kang, Yoo Seob Shin, and Chul-Ho Kim. "Liquid-type non-thermal atmospheric plasma ameliorates vocal fold scarring by modulating vocal fold fibroblast." Experimental Biology and Medicine 244, no. 10 (May 14, 2019): 824–33. http://dx.doi.org/10.1177/1535370219850084.

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Injection laryngoplasty is a widely used therapeutic option for drug delivery into vocal folds (VFs). Efficient injectable materials are urgently needed for treating intractable VF disease. Liquid-type non-thermal atmospheric plasma (LTP) has been found to be useful for various biological applications, including in regenerative medicine. We evaluated the effects of LTP on VF regeneration. Migration and matrix metalloproteinase-2 expression of lipopolysaccharide (LPS)-treated human vocal fold-derived mesenchymal stem cells (VF-MSCs) were enhanced by LTP treatment. LTP treatment not only ameliorated nuclear factor-κB and interleukin-6 activation, induced by LPS treatment, but also the increased manifestation of α-smooth muscle actin and fibronectin, induced by transforming growth factor-ß. In a rabbit VF scarring animal model, histological analyses showed increased hyaluronic acid deposition and decreased collagen accumulation after LTP injection. Videokymographic analysis showed more improved vibrations in LTP-treated VF mucosa compared to those in non-treated group. In conclusion, LTP treatment enhanced the recruitment and activation of VF-MSCs. Regulated extracellular matrix (ECM) synthesis and eventual functional improvement of scarred VFs were observed upon LTP treatment. The results of this study suggest that LTP injection can enhance wound healing and improve functional remodeling following VF injury. Impact statement Voice disorder has a significant impact on life quality, and one of the major causes of this voice disorder is vocal fold scarring. Therefore, various approaches have been tried to treat for voice disorder. However, no method has satisfied all requirements until now. Plasma medicine, which involves the medical application of plasma, is a rapidly developing field. We have confirmed that liquid-type plasma improved vocal fold scarring by mobilizing and activating vocal fold fibroblast. In conclusion, liquid-type plasma is a potential therapeutic agent for promoting vocal fold scarring through simple injection and it may be an alternative therapeutic agent for the current situation to treat voice disorder.
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Lungova, Vlasta, Kate V. Griffin, Tadeas Lunga, and Susan L. Thibeault. "Drainage of amniotic fluid delays vocal fold separation and induces load-related vocal fold mucosa remodeling." Developmental Biology 466, no. 1-2 (October 2020): 47–58. http://dx.doi.org/10.1016/j.ydbio.2020.08.003.

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Thibeault, Susan L., Wenhua Li, and Stephanie Bartley. "A method for identification of vocal fold lamina propria fibroblasts in culture." Otolaryngology–Head and Neck Surgery 139, no. 6 (December 2008): 816–22. http://dx.doi.org/10.1016/j.otohns.2008.09.009.

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Objective Vocal fold biology research is emerging as a vital area of study in laryngology. One impediment is the lack of both commercially available vocal fold lamina propria fibroblasts and a constitutively expressed specific marker for fibroblasts. We present an in vitro technique that allows for identification of fibroblasts by ruling out the possibility of the cells belonging to other lineages that are found in vocal fold tissue. Study Design An in vitro study. Methods Two primary vocal fold fibroblast cell lines and one immortalized vocal fold fibroblast cell line were cultured. Immunohistologic staining for α-actinin, cytokeratin 19, and von Willebrand factor was completed for the three fibroblast lines in addition to skeletal, endothelial, and epithelial cell lines. Cell type was differentiated by positive staining for α-actinin, cytokeratin 19, and von Willebrand factor. Results Fibroblast cultures did not express α-actinin, cytokeratin 19, and von Willebrand factor, whereas skeletal muscle, endothelial, and epithelial cultured cells expressed each respectively. Conclusions This simple rule-out methodology for fibroblast confirmation is an important step when establishing cell culture, and it establishes sound internal validity particularly in the early stages of this emerging area of study.
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Cox, Abigail, and Preeti M. Sivasankar. "Investigating the pathobiology of vocal fold dehydration." FASEB Journal 34, S1 (April 2020): 1. http://dx.doi.org/10.1096/fasebj.2020.34.s1.02611.

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King, Suzanne N., Fei Chen, Marie E. Jetté, and Susan L. Thibeault. "Vocal fold fibroblasts immunoregulate activated macrophage phenotype." Cytokine 61, no. 1 (January 2013): 228–36. http://dx.doi.org/10.1016/j.cyto.2012.09.023.

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Fuja, Tannin J., Erin M. Ostrem, Megan N. Probst-Fuja, and Ingo R. Titze. "Differential cell adhesion to vocal fold extracellular matrix constituents." Matrix Biology 25, no. 4 (May 2006): 240–51. http://dx.doi.org/10.1016/j.matbio.2006.01.004.

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Lungova, Vlasta, and Susan L. Thibeault. "Mechanisms of larynx and vocal fold development and pathogenesis." Cellular and Molecular Life Sciences 77, no. 19 (April 6, 2020): 3781–95. http://dx.doi.org/10.1007/s00018-020-03506-x.

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Nakamura, Ryosuke, Renjie Bing, Carina P. Doyle, Michael J. Garabedian, and Ryan C. Branski. "Glucocorticoids activate Yes-associated protein in human vocal fold fibroblasts." Experimental Cell Research 405, no. 2 (August 2021): 112681. http://dx.doi.org/10.1016/j.yexcr.2021.112681.

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Tanigami, Yuki, Yoshitaka Kawai, Shinji Kaba, Ryuji Uozumi, Hiroe Ohnishi, Tomoko Kita, Koichi Omori, and Yo Kishimoto. "Establishment of a radiation-induced vocal fold fibrosis mouse model." Biochemical and Biophysical Research Communications 601 (April 2022): 31–37. http://dx.doi.org/10.1016/j.bbrc.2022.02.065.

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Book chapters on the topic "Vocal fold biology"

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Sato, Kiminori. "Pericytes in the Human Vocal Fold Mucosa." In Advances in Experimental Medicine and Biology, 79–93. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-030-02601-1_7.

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Sato, Kiminori. "Heterogeneity of Stem Cells in the Human Vocal Fold Mucosa." In Advances in Experimental Medicine and Biology, 63–80. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-24108-7_4.

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Sato, Kiminori. "The Macula Flava of the Human Vocal Fold as a Stem Cell Microenvironment." In Advances in Experimental Medicine and Biology, 171–86. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-69194-7_9.

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THIBEAULT, SUSAN L. "Hyaluronan Biology in Vocal Fold Morphology and Biomechanics." In Chemistry and Biology of Hyaluronan, 339–50. Elsevier, 2004. http://dx.doi.org/10.1016/b978-008044382-9/50047-9.

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Lungova, Vlasta, and Susan L. Thibeault. "Derivation of Three-Dimensional Human Induced Pluripotent Stem Cell-Derived Vocal Fold Mucosa for Clinical and Pharmacological Applications." In Methods in Molecular Biology. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/7651_2021_392.

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Conference papers on the topic "Vocal fold biology"

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Hewavitharanage, Sajini, Jayavardhana Gubbi, Dominic Thyagarajan, Ken Lau, and Marimuthu Palaniswami. "Estimation of vocal fold plane in 3D CT images for diagnosis of vocal fold abnormalities." In 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2015. http://dx.doi.org/10.1109/embc.2015.7319049.

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Ishii, I., S. Takemoto, T. Takaki, M. Takamoto, K. Imon, and K. Hirakawa. "Real-time laryngoscopic measurements of vocal-fold vibrations." In 2011 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2011. http://dx.doi.org/10.1109/iembs.2011.6091633.

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Chan, R. W. "The human umbilical vein as a biologic scaffold for vocal fold reconstruction." In 2010 36th Annual Northeast Bioengineering Conference. IEEE, 2010. http://dx.doi.org/10.1109/nebc.2010.5458281.

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Wang, Jianglin, and Cheolwoo Jo. "Vocal Folds Disorder Detection using Pattern Recognition Methods." In 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2007. http://dx.doi.org/10.1109/iembs.2007.4353023.

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Li-Jen Chen and L. Mongeau. "Measurements of the contact pressure in human vocal folds." In 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2009. http://dx.doi.org/10.1109/iembs.2009.5334476.

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Turkmen, H. Irem, M. E. Karsligil, and I. Kocak. "Assessment of videolaryngostroboscopy images based on visible vessels of vocal folds." In 2012 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2012. http://dx.doi.org/10.1109/embc.2012.6347423.

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