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Journal articles on the topic 'Vizi occulti'

Author: Grafiati

Published: 9 March 2023

Last updated: 10 March 2023

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1

Ortu, Rosanna. "Alle origini della tutela giuridica del consumatore: fondamenti romanistici della disciplina europea." Zeszyty Naukowe KUL 60, no. 3 (October 27, 2020): 281–97. http://dx.doi.org/10.31743/zn.2017.60.3.281-297.

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Nel presente contributo si sono voluti comparare taluni aspetti della disciplina della tutela del contraente debole nel contratto di compravendita, figura che attualmente coincide con quella del consumatore, concentrando l’attenzione su alcuni istituti presenti nel diritto romano, in cui emergono alcune situazioni di disparità contrattuale. Nella disciplina dell’Editto degli edili curuli, i magistrati repubblicani stabilirono una normativa speciale per la dichiarazione dei vizi occulti nelle vendite di schiavi ed animali, presupponendo una responsabilità oggettiva del venditore che non si fosse attenuto alle disposizioni edilizie. Un intervento importante che andò a definire una settorializzazione della materia, inquadrata all’interno della vendita in generale. Da ciò derivava una sovrapposizione in livelli della disciplina giuridica negoziale: sul piano orizzontale si collocava la regolamentazione della vendita prevista dal ius civile, mentre sul piano verticale si innestava quella speciale, di ius honorarium, prevista dall’Editto degli edili curuli. Tale modalità si riscontra anche in ambito europeo con la Direttiva 1999/44/CE, a proposito della vendita di beni di consumo, che rappresenta la manifestazione più eclatante del ruolo che il legislatore europeo ha nell’ambito della protezione del consumatore in materia contrattuale. Come nel mondo antico, nella Direttiva 1999/44/CE l’intervento normativo è giustificato dall’esigenza di creare uno spazio di tutele maggiori destinate a determinati soggetti, nonché delimitate per contenuto e ambito.

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2

Pacheco Cano, Carlos I., Marilyn A. Arosemena, Roumen B. Iordanov, Ankitha Lingamaneni, and Ankur Aneja. "Acquired Factor VIII Inhibitor Presenting as Occult GI Bleeding." Case Reports in Hematology 2018 (June 19, 2018): 1–3. http://dx.doi.org/10.1155/2018/1910854.

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An acquired coagulation factor deficiency is characterized by acquired autoantibodies against specific clotting factors in those without diagnosed hemophilia. It is a relatively rare condition with an incidence of approximately one case per million per year. We present a case report of an elderly male who initially presented with an occult GI bleed that was identified with a positive fecal occult blood test result. This is the first case reported to our knowledge of an acquired factor inhibitor deficiency presenting in this manner. We postulate the importance of acquired factor inhibitors in the setting of unexplained anemia given absence of overt clinical symptoms that could contribute to aggravate an established GI bleed, especially in the elderly population.

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Tan, Chieh Suai, Kenneth P. Chan, Charles T. Chuah, Heng Joo Ng, Foong Koon Cheah, Felicia S. Teo, and Philip CT Eng. "Life Threatening and Occult Mediastinal Haemorrhage Secondary to Acquired Factor VIII Deficiency." Annals of the Academy of Medicine, Singapore 38, no. 3 (March 15, 2009): 280–81. http://dx.doi.org/10.47102/annals-acadmedsg.v38n3p280.

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4

Gibeili, Chloé, Arek Sulukdjian, Audrey Chanlon, and Nathan Moreau. "Unilateral glossodynia as a harbinger of an occult cerebellopontine angle tumour." BMJ Case Reports 15, no. 4 (April 2022): e249408. http://dx.doi.org/10.1136/bcr-2022-249408.

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A woman in her late 80s with severe bronchomalacia was referred to a tertiary orofacial pain clinic for unexplained right unilateral glossodynia of progressive and continuous evolution for the past 8 months, spreading to the ipsilateral labiomental region, associated with ipsilateral hypoacusia. Local and general clinical examinations were unremarkable and routine blood work could not reveal any underlying systemic disease explaining the glossodynia and burning/pricking labiomental pain. Suspecting a painful trigeminal neuropathy secondary to a space-occupying lesion, a cerebral MRI was prescribed, revealing an ipsilateral cerebellopontine angle lesion, compatible with either a schwannoma or meningioma. This lesion invaded the root entry zones of cranial nerves V and VIII explaining the patient’s oral pain and hypoacusia. Following a neurosurgical consultation where surgical treatment was rejected, her pain was successfully managed by topical pregabalin mouthwashes, to prevent any risk of respiratory depression related to her underlying severe bronchomalacia.

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Tibesar, Eric E. "Bleeding Gastric Heterotopic Polyp in the Duodenum of a Teenager with Severe Factor VII Deficiency." Case Reports in Gastroenterology 14, no. 3 (October 8, 2020): 467–71. http://dx.doi.org/10.1159/000508441.

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Heterotopic gastric tissue can be found throughout the intestinal tract, and when it is present in the small intestine, it can present with symptoms that include gastrointestinal bleeding, chronic abdominal pain, diarrhea, and chronic dyspepsia. This finding is incredibly rare in pediatrics, but if present, it can lead to significant morbidity and mortality. This can be especially true if a patient presents with a comorbidity of a bleeding disorder. We here present the case of a teenage male with a history of severe factor VII deficiency who was found to have iron deficiency anemia resulting in multiple blood transfusions from an occult lower gastrointestinal bleed. He was ultimately found to have a bleeding gastric heterotopic polyp in his duodenum that was successfully removed via surgery.

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Mahendradas, Padmamalini, Rohit Shetty, Kavitha Avadhani, Cecil Ross, Anchal Gupta, and Bhujang K. Shetty. "Polycythemia Vera and Increased Hemophilic Factor VIII Causing Acute Zonal Occult Outer Retinopathy: A Case Report." Ocular Immunology and Inflammation 18, no. 4 (July 21, 2010): 319–21. http://dx.doi.org/10.3109/09273941003798767.

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Lopetegui Lia, Nerea, Abigael Luke, Syed Daniyal Asad, Shashank Sama, Leo J. Wolansky, and Upendra P. Hegde. "Intracranial bleeding following soccer‐related head trauma in a young student with occult factor VII deficiency." Clinical Case Reports 8, no. 11 (October 3, 2020): 2148–51. http://dx.doi.org/10.1002/ccr3.3094.

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8

Agostini, Vanessa, Chiara Biasoli, Rino Biguzzi, Rita Santarelli, and Pietro Leoni. "Case Report: Coexistence of Factor VIII Inhibitor and Lupus Anticoagulant." Blood 110, no. 11 (November 16, 2007): 3948. http://dx.doi.org/10.1182/blood.v110.11.3948.3948.

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Abstract Acquired haemophilia is a very rare (1,5 per million per year) and serious coagulophaty that is associated with significant morbidity and mortality. This disorder is caused by the development of autoantibodies directed against coagulaton factor, usually for factor (F) VIII. About half of the cases occurred in apparently healthy people and were considered idiopathic, although there were others known associations, including postpartum period, autoimmune disease, cancer and drugs. The simultaneous presence of F VIII inhibitor and lupus anticoagulant (LAC) is extremely rare and the differentiation between these two conditions is crucial because the clinical manifestation range from massive, life-threatening haemorrhage to thrombosis. We report a case of 78 years old men affected by acquired haemophilia presentig with gluteus and right forearm non traumatic haematoma and anemia. The activated partial thromboplastin time (aPTT) was prolonged at 158,5s (normal 20–35s), with a normal prothrombin time (PT) of 9,88s (normal 9–13s). An aPTT inhibitor screening was positive, with demonstration of time-dependent inhibition. F VIII activity was reduced at 0,26% (normal 58,5–131,7%) and F VIII inhibition level was 41,53 Bethesda Units (BU). The patient was also found to have LAC. Screening tests for antinuclear antibodies, viral titres, occult cancer and cardiolipin antibodies were negative, chest Xray was negative and venous ultrasonografy of lower limbs was performed in order to exclude a concomitant deep venous thrombosis. At the admittance in hospital the patient received packed red cells transfusions for the anemia and treatment with prednisone 1mg/kg once daily in order to autoantibody eradication. After a week was associated therapy with cyclophosfamide 500mg per meter squared every 21 days. The acute bleeding stopped without using bypassing agents or recombinant activated F VII. One month after the institution of the immunosoppressive therapy the F VIII level was 0,9% and the inhibitor level was decreased at 9 B.U. After six cycles of cyclophosfamide and prednisone, tapered at 12,5 mg once daily, F VIII level raised at 16,05% but the inhibitor level remined 6,49 B.U., so was decided to change the immunosoppressive treatment and cyclosporin was administrated at the dose of 50 mg once daily. three months later the aPTT was 26s and factor level was 118% and the cyclosporin treatment discontinuated; thirty days after the aPTT was again 58 s and FVIII levels decreased at 78% so the immunosoppressive treatment was reintroduced at the same dosage of 50 mg daily. The patient had a good performance status without side-effects treatment related and without haemorragic complications. cyclosporin was tailed off successfully two months later after obtained a stabilization of F VIII level at 80% and disappearance of the inhibitor. The aPTT value was 52s and LAC persisted present without thromboembolic manifestation and evidence of autoimmune disorder. Conclusion: idiophatic acquired haemophilia A occurs most frequently in older adults and often presents acutely with life-threatening haemorragies; the advanced age of patients sometimes limits the therapeutic options precluding the most aggressive treatments and necessitating dose reductions of drugs. Our patieny outlines the potential role of cyclosporin in the treatment of acquired haemophilia even at the lower doses of 50 mg daily. The concomitant presence of LAC probably mitigates the bleeding episodes caused by acquired F VIII deficiency and viceversa.

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Roe, Sophie. "Monica Black and Eric Kurlander, eds.: Revisiting the “Nazi Occult”: Histories, Realities, Legacies . Rochester, NY: Camden House, 2015; pp. viii + 297." Journal of Religious History 43, no. 4 (December 2019): 560–61. http://dx.doi.org/10.1111/1467-9809.12615.

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10

Monas, Sidney. "Book ReviewsThe Occult in Russian and Soviet Culture.Edited by Bernice Glatzer Rosenthal. Ithaca, N.Y.: Cornell University Press, 1997. Pp. vii+468." Journal of Modern History 71, no. 2 (June 1999): 517–18. http://dx.doi.org/10.1086/235287.

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11

Allen, J. S. "DAVID ALLEN HARVEY. Beyond Enlightenment: Occultism and Politics in Modern France. DeKalb: Northern Illinois University Press. 2005. Pp. viii, 267. $38.00." American Historical Review 111, no. 5 (December 1, 2006): 1613–14. http://dx.doi.org/10.1086/ahr.111.5.1613.

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12

Magrini, Paolo, Paolo Marcia, and Achille Casale. "DUE NUOVE SPECIE SINTOPICHE DI TYPHLOREICHEIA DELLA SARDEGNA SUD-ORIENTALE (Coleoptera, Carabidae)." Fragmenta Entomologica 43, no. 2 (October 31, 2011): 117. http://dx.doi.org/10.4081/fe.2011.39.

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Vengono descritte e illustrate due nuove specie sintopiche di <em>Typhloreicheia</em> della Sardegna sud-orientale: la prima, <em>T. carlonnisi</em> n. sp., campionata alla base del pozzo d’ingresso della Grotta Su Pittiolu de Gospuru (Armungia, Cagliari), la seconda, <em>T. paladinii</em> n. sp., campionata sotto i massi che circondano l’ingresso della medesima cavità e sul Monte Lora presso San Vito (Muravera). La prima risulta affine per molti caratteri alle specie del “gruppo angelae” (sensu Magrini 2003a), e si distingue dalle altre <em>Typhloreicheia</em> note di Sardegna per la combinazione dei seguenti caratteri: piccole dimensioni, tempie appiattite e poco sporgenti, elitre con setole discali presenti nelle interstrie 2-3-5-7 e margini laterali con denticoli presenti fino all’apice; edeago breve, con apice del lobo mediano sottile e incurvato ventralmente in visione laterale, asimmetrico in visione ventrale. Lamella copulatrice costituita da una lamina allungata con apice arrotondato, con la porzione dorsale nettamente sclerificata in forma di artiglio. La seconda, appartenente al “gruppo occulta” (sensu Magrini & Bulirsch 2002), si differenzia dall’affine <em>Typhloreicheia</em> viti Magrini & Bulirsch, 2002 per le elitre più allungate e meno convesse, per l’edeago più robusto, con lobo mediano meno appuntito e appena incurvato a sinistra in visione ventrale e apice più corto e largo in visione laterale, e per la lamella copulatrice con apice più arrotondato; le differenze nettamente maggiori nei confronti delle altre specie del gruppo sono evidenziate nella chiave dicotomica allegata. La spettacolare radiazione adattativa del genere <em>Typhloreicheia</em> in Sardegna, recentemente proposta e discussa da uno degli autori del presente contributo (A.C.), e le ipotesi concernenti l’origine di questa linea di Reicheiina nell’isola, sono richiamate ed evidenziate alla luce dei nuovi dati.

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13

Ball, Christopher. "The Occult Life of Things: Native Amazonian Theories of Materiality and Personhood edited by FernandoSantos-Granero, ed. Tucson: University of Arizona Press, 2009. viii + 277 pp." Journal of Linguistic Anthropology 22, no. 3 (December 2012): 239–41. http://dx.doi.org/10.1111/j.1548-1395.2012.01168.x.

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Kselman, Thomas. "Beyond Enlightenment: Occultism and Politics in Modern France. By David Allen Harvey. DeKalb: Northern Illinois University Press, 2005. viii + 274 pp. $38.00 cloth." Church History 76, no. 1 (March 2007): 200–201. http://dx.doi.org/10.1017/s0009640700101696.

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Tarango, Cristina, Anne Blackmore, and Joseph S. Palumbo. "Chronic IVC Occlusion Predisposing to Acute Lower Extremity DVT in Children." Blood 126, no. 23 (December 3, 2015): 4724. http://dx.doi.org/10.1182/blood.v126.23.4724.4724.

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Abstract Congenital atresia of the inferior vena cava (IVC) is a known risk factor for spontaneous lower extremity thrombosis in adults. However, little is known about the incidence of IVC occlusion and its relationship to spontaneous lower extremity thrombosis in children. We reviewed the medical records of consecutive patients with IVC occlusion and lower extremity DVT who presented to our institution between 2008 and 2015. Data were reviewed for risk factors for thrombosis, treatment, and outcomes including recurrent thrombosis, bleeding complications, and post-thrombotic syndrome. This represents the largest reported analysis of previously healthy pediatric patients with occult chronic IVC occlusion presenting with unprovoked acute lower extremity thrombosis. Ten patients aged 13 to 18 years (median age 16.5yrs, 90% male) presenting with acute lower extremity thrombosis were found to have chronic occlusion of the IVC. One patient presented with pulmonary embolism. Seven patients underwent site-directed thrombolysis, and 3 patients received anticoagulation alone. All patients had persistent IVC occlusion regardless of treatment. Two patients had recurrent thrombosis while on anticoagulation. There were no provoking factors identified that preceded the presentation of acute lower extremity thrombosis, and none had predisposing risk factors that could explain the IVC occlusion. Four patients had a negative thrombophilia work up. Five had mild thrombotic risk factors such as heterozygosity for Factor V Leiden or elevated factor VIII levels. Only one patient had a significant thrombophilic risk factor, familial mild protein C deficiency. Five patients had post thrombotic syndrome based on standardized scoring tools. All patients remain on indefinite anticoagulation. This case series suggests that chronic IVC occlusion increases the risk of unprovoked lower extremity thrombosis and pulmonary embolism in healthy children with resultant long-term complications. It also highlights the importance of imaging the IVC in young patients with unprovoked or minimally provoked iliofemoral DVT. Indefinite anticoagulation in patients presenting with unprovoked thrombosis secondary to IVC occlusion should be considered. Disclosures No relevant conflicts of interest to declare.

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Hunt, Emily. "Jill Galvan, The Sympathetic Medium: Feminine Channelling, The Occult, and Communication Technologies, 1859–1919 (Ithaca: Cornell University Press, 2010), 216 + viii pp., £29.50, $45.00 (USD), €33.54, ISBN-13: 978-0801448010." Victoriographies 2, no. 1 (May 2012): 68–70. http://dx.doi.org/10.3366/vic.2012.0064.

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Garcilazo-Reyes, Y., N. Zapata-Canto, B. Cacho-Díaz, O. Navarro-Fernández, R. Espinoza-Zamora, A. Bonilla-Navarrete, and A. Avilés-Salas. "P11.71.B Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) in a patient with blastic plasmacytoid dendritic cell neoplasm: a rare neurologic manifestation in a rare disease." Neuro-Oncology 24, Supplement_2 (September 1, 2022): ii75. http://dx.doi.org/10.1093/neuonc/noac174.260.

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Abstract Background Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare aggressive myeloid hematological malignancy. Skin lesions, bone marrow, lymph nodes or visceral organs can be involved. 30% of patients will have infiltration to the nervous system,occult asymptomatic infiltration is frequent. Immunophenotype express CD4, CD56, and CD123, and flow cytometry is essential. Material and Methods 70-yo Hispanic male with a 1-month history of multiple violaceous cutaneous nodules and adenopathies.Neurological complaints included diplopia, hypoesthesia in the left face, dysphagia, gait difficulties, and generalized weakness with distal hypoesthesia. Examination revealed multiple cranial neuropathy (bilateral VI and VII nerve palsies, left V3 and VIII palsies and IX, X involvement), global areflexia, length-dependent weakness, ataxic gait and cerebellar syndrome. An inguinal ganglionar biopsy retrieved cells positive for CD4, TCL1, CD68 and CD123, whereas CD3, CD20, CD7, CD8, CD30 and myeloperoxidase were negative. PET/CT showed multiple supra and infradiaphragmatic adenopathies, bilateral pleural, pericardial and abdominal implants. Bone marrow biopsy was negative. Brain MRI showed contrast enhancement in the cerebellar folia and in the roots of the cranial nerves clinically involved. Multiple CSFs demonstrated high protein count (281- 310mg/dl), normal glucose and cell count; CSF flow cytometry and cytology reported no blastic infiltration (negative CD4, CD56 and CD123), CSF onconeuronal antibodies were negative. Nerve conduction studies fulfilled definite electrodiagnostic EFNS criteria for CIDP. Sural nerve biopsy reported inflammatory demyelination without infiltration. Systemic chemotherapy (Cyclophosphamide/Vincristine) with intrathecal cytarbine/methotrexate was administered. Results Favorable initial, but brief response was noticed for the cranial nerves and gait. He had neurological relapse with gait impossibility. Neuraxis MRI showed no contrast enhancement in the brain but new contrast enhancement of lumbosacral roots. Nerve conduction studies reported severe worsening criteria of CIDP. The PET/CT demonstrated complete response. Five days of methylprednisolone (1gr IV) followed by oral prednisone were prescribed (50 mg qd). However, two weeks later he suffered clinical neurological worsening with respiratory failure. IVIg was started (.4g/kg/day for 5 days) with no improvement; palliative care decision was consented. Conclusion We report the case of an adult male with multiple cranial nerve palsy, cerebellar syndrome and refractory rapidly progressive asymmetric polyneuropathy with BPDCN. CIDP in the absence of multiple attempts to demonstrate nervous system infiltration led us to consider this as a paraneoplastic phenomenon refractory to treatment. To our knowledge no CIDP has been reported in this rare disease

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Waddell, Mark A. "Michael Hunter. The Occult Laboratory: Magic, Science and Second Sight in Late Seventeenth-Century Scotland. Rochester, N. Y.: Boydell and Brewer. 2001. Pp. vii, 247. $90.00. ISBN 0-85115-801-3." Albion 34, no. 3 (2002): 551–52. http://dx.doi.org/10.2307/4054805.

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Molland, George. "Michael Hunter (Editor). The Occult Laboratory: Magic, Science, and Second Sight in Late Seventeenth‐Century Scotland. vii + 247 pp., illus., app., bibl., index. Suffolk, England/Rochester, N.Y.: Boydell Press, 2001. $90." Isis 94, no. 1 (March 2003): 150–51. http://dx.doi.org/10.1086/376139.

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Helmer, Étienne. "Marginalisation et intégration dans la cité: éléments pour une lecture dynamique de la pensée politique de la République." ΠΗΓΗ/FONS 2, no. 1 (December 14, 2017): 45. http://dx.doi.org/10.20318/fons.2017.3857.

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Résumé: On estime souvent que le coeur de la réflexion politique de Platon dans la République porte sur les conditions de possibilité de la cité juste. Une telle lecture se concentre alors sur l’institution des philosophes-rois, et sur l’organisation tripartite ou trifonctionnelle de la cité, avec à la clé un débat sur le caractère utopique ou non de cette construction politique. Sans être fausse, cette lecture est toutefois extrêmement partielle et réductrice en ce qu’elle occulte le point essentiel de la pensée politique de Platon dans ce dialogue: celle-ci ne se limite pas à l’analyse des conditions de possibilité de la cité juste, mais concerne plus généralement l’ensemble des processus d’intégration et de marginalisation de différentes catégories de population et de différentes fonctions requises pour édifier la cité. Trois arguments vont dans ce sens, que mon article présentera de façon détaillée. Premièrement, les difficultés d’élaboration du régime juste en raison des rapports tendus entre l’économie et la politique (livre II), ainsi que la dégradation des régimes sous l’effet du conflit entre ces deux sphères (livre VIII) invitent à voir dans la République une réflexion sur la politique comme dynamique socio-économique, plutôt qu’une description de la structure politique et économique statique sur laquelle se fonde la cité juste. Deuxièmement, les trois caté-gories fonctionnelles requises pour édifier la cité juste sont moins présentées comme des éléments prêts à y être intégrés et à y exercer leur tâche propre que comme des éléments dont le statut reste problématique et qui sont sujets à de nombreuses trans-formations affectant l’équilibre de l’ensemble de la cité. Cela se vérifie notamment à propos des philosophes, tant en ce qui concerne leur existence et leur éducation que leur préservation. Troisièmement, Platon ne se contente pas dans ce dialogue de dé-crire les trois catégories fonctionnelles qui composent la Kallipolis. Il y évoque aussi des catégories en apparence secondaires - les enfants sans talent, les mendiants, les in-curables - dont il signale le degré d’intégration ou de marginalisation variable selon la forme du régime et les forces qui l’animent.Mots-clés: Cité, exclusion, intégration, marginalisation, Platon, République Abstract: It is often assumed that the heart of Plato’s political thought in the Republic addresses the conditions of possibility of the just city. Such a reading then concentrates mostly on the institution of the philosopher-kings, and the tripartite organization of the city. Without being wrong, this reading is however extremely partial and reductive as it obscures the main focus of Plato’s political thought in this dialogue. Far from analyzing only the conditions of possibility of the just city, Plato’s main concern deals with the processes of marginalization and integration of distinct population groups and functions in the city. Three arguments go in this direction. First, both the antagonistic relationships between economy and politics at the first stages of the city (Book II), and the progressive degradation of the regimes as a result of the conflict be-tween these two spheres (Book VIII), invite us to read the Republic as a reflection on politics considered as a socio-economic dynamic, rather than a mere description of the static political and economic structure of the just city. Second, the three functional categories required to build this city are less presented as elements ready to be put at work, than as problematic elements, which are subject to many changes. This is especially true about the philosophers, with respect to their existence, education and preservation. Third, Plato also evokes secondary categories, in the just city and the ordinary cities as well - for instance, the children without talent, the beggars, the incurables - and he wonders about how and how far they can or must be integrated in-to or marginalized from the cities.Keywords: City, exclusion, integration marginalization, Plato, Republic

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Heath, Michael. "Cornelius Agrippa. De occulta philosophia libri tres. Edited by V. Perrone Compagni. (Studies in the History of Christian Thought, XLVIII.) Pp. vii + 657. Leiden-New York-Cologne: Brill, 1992. Gld. 295/$168.75. 90 04 09421 0." Journal of Ecclesiastical History 45, no. 1 (January 1994): 150–52. http://dx.doi.org/10.1017/s0022046900016663.

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Revel-Vilk, Shoshana, Ariel Revel, Michal Lipschuetz, David Varon, and Ora B. Paltiel. "Menorrhagia In Adolescents: The Tip of the Iceberg." Blood 116, no. 21 (November 19, 2010): 3654. http://dx.doi.org/10.1182/blood.v116.21.3654.3654.

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Abstract Abstract 3654 Background: Menorrhagia in adolescents could be the first sign of a bleeding disorder. Prior research has found occult bleeding disorders, e.g. von Willebrand disease, in women with menorrhagia. We hypothesized that most adolescents girls with menorrhagia do not seek medical attention; thus we performed a survey of adolescents girls in their schools. Methods: Between February and April, 2008 we presented the study to 705 adolescents girls in six schools. The presentation included a short lecture and completion of a questionnaire. Due to ethical regulations the questionnaire could include only general information without any identifying data. The adolescents were asked if the thought they had heavy periods. The answers options were “yes”, “no”, “sometimes”, and “do not know”. After providing parental and individual consent, 94 adolescents girls completed a detailed personal and family (Hospital for Sick Children) HSC bleeding questionnaire and a pictorial bleed assessment chart (PBAC) during the next menstrual cycle. A blood sample was taken from 62 adolescents (66%) for complete blood count, partial thromboplastin time, prothrombin time, factor VIII, von Willebrand factor (VWF) activity and antigen. The distribution of age, years since menarche and response to the initial question regarding heavy periods was similar among the entire approached population, those who consented and those who had laboratory evaluation (Table 1). Results: One hundred and five adolescents girls (15%) reported they had heavy periods on the initial questionnaire. An additional 21% reported to have heavy periods sometimes. Frequency of perceived menorrhagia was not associated with age or years since menarche. Among the 94 girls who completed the full questionnaires, menorrhagia based on a PBAC ≥ 100 and/or a positive answer on the HSC questionnaire was found in 34 adolescents (36%, 95% CI 26.5%-46.7%). Almost a third of those adolescents (11/34) did not perceive they had menorrhagia according to their response on the initial questionnaire. Prevalence of menorrhagia was not associated with age, years since menarche, family history of bleeding symptoms or evidence of other bleeding symptoms. Hemoglobin levels were significantly lower in those with vs. those without menorrhagia, mean±SD, 12.6±1 vs. 13.2±0.8 (p=0.025). Of the six adolescents with hemoglobin <12 g/dL, only two were aware they had anemia. Menorrhagia was not significantly associated with coagulation abnormalities. One girl with menorrhagia was found to have borderline VWF levels. Discussion: Menorrhagia is under-diagnosed in adolescents. By using standardized questionnaires, we were able to identify a group of girls with menorrhagia associated with higher risk of anemia. Importantly, some of these girls were not aware they had a problem. The lack of association between menorrhagia and coagulation abnormalities could be related to the small sample size or to the non-selective nature of the study participants (inclusion of girls with menorrhagia who did not seek medical attention). Yet, we believe that questioning adolescents for menorrhagia is important as it could contribute to their improved well-being. The low participation rate further highlights the difficulty in doing research in this area. Disclosures: No relevant conflicts of interest to declare.

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ELMER, PETER. "MICHAEL HUNTER (ed.), The Occult Laboratory: Magic, Science and Second Sight in Late Seventeenth-Century Scotland. A New Edition of Robert Kirk's The Secret Commonwealth and Other Texts. Woodbridge: Boydell Press, 2001. Pp. vii+247. ISBN 0-85115-801-3. £50.00, $90.00 (hardback)." British Journal for the History of Science 35, no. 2 (June 2002): 213–50. http://dx.doi.org/10.1017/s0007087402304709.

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Rezazadeh, Arash, Patricia P. Ashby, and Vivek R. Sharma. "Use of Recombinant Factor VIIa (rVIIa) for Treatment of Bleeding in Type II B Von Willebrand Disease: A Case Report." Blood 112, no. 11 (November 16, 2008): 4514. http://dx.doi.org/10.1182/blood.v112.11.4514.4514.

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Abstract Background: Von Willebrand disease (vWD) is an inherited bleeding disorder caused by a deficiency or dysfunction of von Willebrand’s factor (VWF). Type 2 vWD is a qualitative deficiency of VWF with the IIB variant being caused by a “gain of function” mutation that results in increased affinity of the vWF for platelet GPIb. Treatment of choice for bleeding episodes is factor VIII-VWF concentrate or DDAVP in selected cases. We are reporting a case of type IIB vWD where rVIIa was used successfully for hemostasis. Case report: A 28 year old white female with type IIB vWD had being doing well with Humate-P® which she used most frequently for menorrhagia. She had also been treated successfully with Humate-P® for peri-operative hemostasis during back surgery but approximately 3 years after this developed anaphylactic reaction while getting humate-P for an episode of severe menorrhagia. A test dose of a different lot of Humate-P® in the hospital also resulted in a severe reaction. Administration of Koâte®-DVI and Alphanate® was subsequently attempted but caused similar anaphylactic reactions after the first few doses. She had normal IgA levels. Amicar and hormonal therapy was used to control the menorrhagia to where she was able to maintain a relatively stable Hgb level and not require frequent PRBC transfusion. Unfortunately, a few months later the patient developed GI bleeding from what was initially an occult source and ended up needing upwards of 40 units of PRBC transfusion over a period of two months. She was offered options of trying cryoprecipitate as well as DDAVP but refused after weighing the risks and benefits. At this time, rVIIa was given and the bleeding appeared to slow down resulting in lesser frequency of transfusion but it did not entirely stop. After several unsuccessful attempts to locate the source, a tagged RBC study finally found the bleed originating near the cecal area which eventually turned out to be a malignant ileocecal carcinoid that had been missed on initial colonoscopy as well as on capsule camera endoscopy. There was no clincally overt carcinoid syndrome. Patient underwent a right hemicolectomy and received rVIIa perioperatively according to the protocol approved for patients with hemophilia with factor inhibitor. She received NovoSeven® 90 mcg/kg before the surgery and then q2h for the first 24 hours. She had rVIIa q3h on post-op day one. The dose frequency was dropped to q4h on day 2 followed by q6h on post-op days 3 to 7. This provided excellent perioperative hemostasis. She has done well with no further GI bleed or recurrence of the tumor after more than a year and her menorrhagia is fairly well controlled with hormonal therapy and amicar. Discussion: Factor VII, a vitamin K-dependent glycoprotein, promotes hemostasis by activating the extrinsic pathway of the coagulation cascade. Although it does not affect the vWF level it probably bypasses the deficiency via thrombin generation on platelet surface. In literature search we found two case reports regarding utilizing rFVII in vWD, both with uncontrolled bleeding despite adequate factor replacement. First case with acquired vWD and GI bleed and the second case was inherited vWD with GI angiodysplasia. The precise mechanism of action in this setting however is not fully understood. Conclusion: To our knowledge this is the first report of utilizing rVIIa in a patient intolerant to vWF without inhibitors to vWF. rVIIa should be considered a viable option for hemostasis in patients unable to tolerate vWF due to severe allergy.

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Starn, Randolph. "Raffaella Castagnola, ed. I Guicciardini e le scienze occulte: L'oroscopo di Francesco Guicciardini; Lettere di alchimia, astrologia e cabala a Luigi Guicciardini. (Istituto Nazionale di Studi sul Rinascimento, Studi e Testi, 19.) Florence: Leo S. Olschski Editore, 1990. 8 pls. + vii + 397 pp. L. 85.000." Renaissance Quarterly 46, no. 1 (1993): 209–10. http://dx.doi.org/10.2307/3039176.

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Baldwin, Martha. "Raffaella Castagnola (ed.) I Guicciardini e le scienze occulte: L'oroscopo di Francesco Guicciardini, lettere di alchimia, astrologia e cabala a Luigi Guicciardini. Istituto Nazionale di Studi sul Rinascimento, Studi e Testi XIX. Florence: Leo S. Olschki Editore, 1990. Pp. vii+ 397. ISBN 88-222-3761-7. L. 85000." British Journal for the History of Science 24, no. 3 (September 1991): 374–75. http://dx.doi.org/10.1017/s0007087400027448.

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Alvar Nuño, Antón. "The power of things: the materiality of magic in the Roman empire - ADAM PARKER and STUART MCKIE (edd.), MATERIAL APPROACHES TO ROMAN MAGIC. OCCULT OBJECTS & SUPERNATURAL SUBSTANCES (TRAC Themes in Roman Archaeology, vol. 2; Oxbow Books, Oxford2018). Pp. vii + 135, figs. 58. ISBN 978-1-78570-881-7. £40." Journal of Roman Archaeology 33 (2020): 592–98. http://dx.doi.org/10.1017/s1047759420000173.

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Roberts, Jonathan C., Miguel A. Escobar, Suchitra Acharya Acharya, Nina Hwang, Michael Wang, Sarah A. Hale, Abiola Oladapo, Sohaib Asghar, Syed Mehdi, and Peter A. Kouides. "Retrospective Chart Review of Gastrointestinal Bleeding in Patients with Von Willebrand Disease." Blood 136, Supplement 1 (November 5, 2020): 20–21. http://dx.doi.org/10.1182/blood-2020-133499.

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Background: Recurrent overt or occult gastrointestinal (GI) bleeding is a serious complication of von Willebrand Disease (VWD) and is the most common cause of hospitalization for patients with VWD. Data from the VWD Prophylaxis Network (VPN) emphasized the importance of prophylaxis in minimizing bleeding episodes in VWD; however, the management of GI bleeding in these patients remains challenging. Despite the availability of von Willebrand factor (VWF) replacement therapy, GI bleeding may be refractory and require the use of multiple treatment approaches. Currently, there are limited published data and no consensus regarding the most effective treatment for GI bleeding in patients with VWD. Aims: To describe the natural history of treatment and management of GI bleeds in patients with VWD, stratified by those patients who have a history of GI bleeding that precedes this chart review versus patients who experienced their first GI bleed within the 5 years of this chart review. Outcomes following the use of VWF replacement products and adjuvant therapy, including recombinant VWF were collected. Methods: This ongoing retrospective, multicenter, observational chart review (abstraction initiated 2019) will include up to 20 patients from 6 US centers with confirmed congenital VWD with ≥1 GI bleed within the last 5 years. Demographics and clinical information, including potential etiology, treatment regimens, will be gathered from patient records on all recorded GI bleeds within the last 5 years. Clinical effectiveness will be defined by treatment response, change in duration of treatment, or time to bleed resolution across treatment cohorts (e.g., prophylaxis vs on-demand; recombinant VWF [rVWF] vs plasma-derived VWF [pdVWF]), at the time of a GI bleed and for any subsequent period of prophylactic treatment to prevent GI bleed recurrence. Data will be analyzed descriptively. Results: To date, data on 37 bleeds in 13 patients with Type 1 (23%), Type 2 (46%) or Type 3 (31%) VWD have been abstracted; 54% were female, mean (±SD) age was 53.9 (22.0) years, 85% had ≥1 recorded GI-specific morbidity, 6 patients (46%) had no history of prior GI bleeding. Three patients (23%) were on regular prophylaxis using pdVWF-factor VIII (FVIII) concentrates at initial GI bleed presentation. All were receiving Humate-P; dose was not recorded for 2 patients and 1 patient received 50 IU/kg. Out of 37 bleeding episodes, 9 (24%) occurred in patients during VWF prophylaxis, of which 7 occurred in 1 patient. Among the 7 patients with a previous history of GI bleeding, 1 was on a prophylactic regimen prior to the initial GI bleeding episode. None of the patients without a history of GI bleeding were on a prophylactic regimen at the initiation of the chart review; 1 patient was receiving prophylaxis at the time the fourth bleed was documented. On-demand treatment for GI bleeding included aminocaproic acid, tranexamic acid, pdVWF-FVIII concentrates, rFVIII, rVWF, corticosteroids, polypectomy, and thalidomide. After resolution of the GI bleeding episode, in 17/37 bleeding events, prophylactic treatment continued (either as part of the final treatment regimen to resolve the bleed and sustained prophylaxis, or after the final treatment regimen purely as prophylaxis). At the conclusion of data collection for the current patients, 4 out of 6 without a GI bleeding history, and 1 out of 7 with a GI bleeding history, were receiving prophylaxis. Conclusions: Data from this retrospective chart review are the first to describe prophylactic regimens prior to and after GI bleeding, in VWD patients with and without a GI bleeding history. More patients with congenital VWD and a history of GI bleeding were treated with prophylaxis following GI bleeds, compared to patients without a history of GI bleeds. These data describe the role of prophylaxis in management of GI bleeding and add to existing data from the VPN describing a modest reduction of GI bleeding in some patients on prophylaxis. These data underscore the continuing unmet need of the successful management of GI bleeding in VWD. Further data will be collected, and additional analyses performed to determine if this trend persists in a larger sample of patients with VWD. Disclosures Roberts: uniQure:Consultancy;Takeda:Consultancy, Research Funding, Speakers Bureau;Pfizer:Consultancy;Novo Nordisk:Consultancy, Speakers Bureau;Sanofi:Consultancy, Speakers Bureau;Octapharma:Consultancy, Speakers Bureau.Escobar:National Hemophilia Foundation:Consultancy, Membership on an entity's Board of Directors or advisory committees;Takeda:Consultancy, Membership on an entity's Board of Directors or advisory committees;Sanofi:Consultancy, Membership on an entity's Board of Directors or advisory committees;Pfizer:Consultancy, Membership on an entity's Board of Directors or advisory committees;Genentech, Inc.:Consultancy, Membership on an entity's Board of Directors or advisory committees;Novo Nordisk:Consultancy, Membership on an entity's Board of Directors or advisory committees.Acharya:Novonordisk, BPL:Membership on an entity's Board of Directors or advisory committees.Hwang:Takeda:Honoraria;Shire:Honoraria.Wang:Bioverativ Inc:Honoraria;CSL Behring:Honoraria;Biomarin:Honoraria;Genentech:Honoraria;Takeda:Honoraria;Bayer:Honoraria.Hale:Takeda Pharmaceutical Company Limited:Current Employment.Oladapo:Takeda:Current Employment, Current equity holder in publicly-traded company.Asghar:HCD Economics:Current Employment.

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Grell, Ole Peter. "Bruce T. Moran. The Alchemical World of the German Court: Occult Philosophy and Chemical Medicine in the Circle of Moritz of Hessen (1572–1632). Sudhoff's Archiv, Beiheft 29. Stuttgart: Franz Steiner Verlag1991. Pp. 193. ISBN 3-515-05369-7. DM 58. - Bruce T. Moran. Chemical Pharmacy Enters the University: Johannes Hartmann and the Didactic Care of Chymiatria in the Early Seventeenth Century. Madison: American Institute for the History of Pharmacy, 1991. Pp. vii + 88. ISBN 0-931292-24-7, $16.50 (hardback); 0-931292-9, $7.50 (paperback)." British Journal for the History of Science 25, no. 3 (September 1992): 360–61. http://dx.doi.org/10.1017/s0007087400029204.

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Houliston, Victor. "Bruce T. Moran, The alchemical wvorld of the German court: occult philosophy and chemical medicine in the circle of Moritz of Hessen (1572–1632), Sudhoffs Archiv, Beiheft 29, Stuttgart, Franz Steiner, 1991, pp. 193, illus., DM 58.00 (paperback, 3-515-05369-7). - Bruce T. Moran, Chemical pharmacy enters the university: Johannes Hartmann and the didactic care of chymiatria in the early seventeenth century, Publication 14 (NS), Madison, Wisc., American Insitute of the History of Pharmacy, 1991, pp. vii, 88, illus., $16.50 (0-931292-24-7), $7.50 (paperback, 0-931292-23-9)." Medical History 36, no. 2 (April 1992): 227–28. http://dx.doi.org/10.1017/s0025727300055095.

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Rabin, Sheila J. "Ole Peter Grell, ed., Paracelsus: The Man and His Reputation, His Ideas and Their Transformation (Studies in the History of Christian Thought, 85.) Leiden and Boston: Brill, 1998. x + 360 pp. $114.75. ISBN: 90-06-11177-8. - Noel L. Brann, Trithemius and Magical Theology: A Chapter in the Controversy over Occult Studies in Early Modern Europe (SUNY Series in Western Esoteric Traditions.) Albany: State University of New York Press, 1998. x + 354 pp. $23.95. ISBN: 0-7914-3962-3. - Richard Kieckhefer, Forbidden Rites: A Necromancer's Manual of the Fifteenth Century (Magic in History.) University Park: Pennsylvania State University Press, 1998. viii + 384 pp. 28 pls. $60 (cl), $19.95 (pbk). ISBN: 0-271-01750-3 (cl), 0-271-01751-1 (pbk)." Renaissance Quarterly 53, no. 3 (2000): 903–6. http://dx.doi.org/10.2307/2901511.

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den Bok, Nico. "Gelukkig wie bestemd is tot geloof: Een systematisch-theologische analyse van Augustinus’ verkiezingsleer in relatie tot de menselijke wilsvrijheid2Bijv. GLA XXI 42: ‘Agit enim omnipotens in cordibus hominum etiam motum voluntatis eorum; vgl. XX 43: ‘quod eius [sc. hominus] voluntatem proprio vitio suo malum in hoe peccatum iudicia suo iusto et occulto inclinavit’. Zie ook De correptione et gratia XIV 43: ‘cui volenti [sc. Deo] salvum facere nullum hominum resistit arbitrium’ en XIV 45: ‘Non est itaque dubitandum, volentati Dei <...> humanas voluntates non posse resistere, quominus faciat ipse quod vult; quandoquidem etiam de ipsis hominum voluntatibus quod vult, cum vult, faciat’ (N.B.: het ‘cum vult’ geeft indirect het vrije van de wilsact aan, op het moment dat/wanneer Hij het wil, gebeurt het, maar Hij kan het ook niet-willen); vgl. PS XX 41. Zie eveneens DP XIII 33: ‘Nos ergo volumus, sed Deus in nobis operatur veile’ en XVII 41: niet alleen het ‘praeparare’ en ‘praevenire’, maar ook het ‘operari’ en ‘facere’ bij het tot geloof komen wordt aan God toegeschreven. Augustinus herhaalt soms, dat Gods wil de wil van mensen meer in Zijn macht heeft dan zij die in hun eigen macht hebben.Eén van de indrukwekkendste teksten is wel CG XII38: ‘Subventum est igitur infirmati voluntatis humanae, ut divina gratia indeclinabiliter et insuperabiliter ageretur et ideo, quamvis infirma, non tarnen deficeret neque adversitate aliqua vinceretur’. Vgl. de close-reading van J. Mausbach, Die Ethik des heiligen Augustinus, BD II: Die sittliche Befähigung des Menschen und ihre Verwirklichung, Freiburg i.Br. 19091, 35; Mausbach leest ook deze zin niet-deterministisch. Andere teksten zijn bijv. CG VIII 17: Als Christus voor Petrus gebeden heeft opdat zijn geloof niet zal bezwijken, kan Petrus’ geloof niet bezwijken, want anders zou Christus’gebed kunnen falen; en PS VIII 13: ‘Haec itaque gratia <...> a nullo duro corde respuitur’." NTT Journal for Theology and the Study of Religion 48, no. 3 (July 1, 1994): 191–204. http://dx.doi.org/10.5117/ntt1994.3.002.bok.

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Sarah Micallef, Kelvin Cortis, and Claude Magri. "Hepatic Necrosis after Trans-Arterial Embolization of Metastatic Neuroendocrine Tumour." European Journal of Case Reports in Internal Medicine, Vol 7 No 5 (March 19, 2020). http://dx.doi.org/10.12890/2020_001530.

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Liver metastases from neuroendocrine tumours (NETs) are usually seen on cross-sectional imaging at presentation. In such cases, curative surgical resection is usually not possible given that most patients have bilobar disease. Various locoregional approaches are now widely available that enable local control of disease and management of systemic symptoms. These include trans-arterial embolization (TAE), trans-arterial chemoembolization (TACE), selective internal radiotherapy and thermal ablation. We describe a rare case of hepatic necrosis after TAE in a 61-year-old woman with a metastatic NET. Cross-sectional imaging showed extensive necrosis affecting segments VII and VIII of the liver. This occurred secondary to thrombosis in the portal vein branches to these segments, confirmed on a Doppler ultrasound scan. The mechanism of portal vein thrombosis after TAE could be due to the presence of occult arterioportal anastomoses. These allow transit of the embolizing agents into the portal vein branches supplying the treated segments and subsequent thrombosis.

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Calipari, Maurizio. "La proporzionalità delle cure negli scritti di Gerald A. Kelly, s.j." Medicina e Morale 55, no. 2 (April 30, 2006). http://dx.doi.org/10.4081/mem.2006.360.

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Il tema della proporzionalità delle terapie e dei mezzi di sostegno vitale è sicuramente uno degli argomenti più vivi ed attuali nel dibattito bioetico. Tra gli autori che più specificamente si sono occupati di questa problematica vi è il Gesuita Gerald A. Kelly, teologo moralista statunitense, che negli anni 50’ ha prodotto diversi lavori sul tema. Il presente contributo, articolato in due parti, dapprima si sofferma ad esporre il contenuto dei principali scritti di Padre Kelly circa la proporzionalità delle cure, evidenziandone in particolare gli elementi di maggiore novità; nella seconda parte, invece, viene presentata un’analisi critica dei contenuti precedentemente esposti, soprattutto in riferimento ad alcuni passaggi “problematici” presenti negli scritti di Kelly. Alla luce di quanto trattato in questo articolo, risulta chiaro come gli studi di Padre Kelly possano rappresentare, ancora oggi, un valido punto di riferimento per una approfondita e maggiormente elaborata riflessione sull’ampio tema della proporzionalità delle cure. ---------- The issue of proportionality of therapies and of life-sustaining means is surely one of the core arguments into the present bioethical debate. Amongst the authors interested in this problems there is the Jesuit Gerald A. Kelly, American moral theologian, who produced a lot of works on this issue, in 50’s of XX century. This article, divided into two parts, shows first the content of the principal Fr. Kelly’s writings on proportionality of therapies, pointing out particularly the elements of main originality, and then presents a critical analysis of the content previously exposed, above all referring to some “problematic” passages present in Kelly’s writings. In the light of what this article shoes, it’s clear how Fr. Kelly’s works can represent, even today, a valid benchmark for a deeper and a more elaborated reflection on the wide issue of proportionality of therapies.

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