Journal articles: 'Vitamin effervescent'

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Permatasari, Jelly, Uce Lestari, and Prago Kaipur. "Sediaan Granul Effervescent Dari Sari Buah Pepaya (Carica papaya L)." Riset Informasi Kesehatan 7, no. 1 (June 30, 2018): 39. http://dx.doi.org/10.30644/rik.v7i1.126.

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ABSTRAK Latar Belakang : Zaman yang semakin modern pola pikir masyarakat lebih senang akan sesuatu yang praktis, dikarenakan aktivitas masyarakat yang sangat padat yang menyebabkan masyarakat lupa dalam menjaga kebutuhan vitamin dan nutrisi yang dibutuhkan tubuh. Umumnya masyarakat lebih senang mengkonsumsi yang serba instan, baik makanan atau minuman. Makanan atau minuman tersebut terkadang hanya memiliki sedikit vitamin yang dibutuhkan tubuh. Buah pepaya (Carica papaya L) merupakan sumber yang kaya akan nutrisi seperti, provitamin A, karotenoid, vitamin C, vitamin B, likopen, mineral diet dan serat makanan. Salah satu alternatif yang baru dalam meningkatkan konsumsi buah pepaya adalah dalam bentuk sediaan granul effervescent instan. Metode : Pada buah pepaya dirancang formula granul effervescent menjadi 3 formula yaitu F1, F2, dan F3 dilakukan proses juicer di dapatkan sari buah pepaya ditambahkan maltodekstrin menghasilkan serbuk, dilakukan 2 fase yaitu fase asam dan fase basa didapatkan granul fase asam dan granul fase basa, setelah itu kedua granul dicampurkan menghasilkan granul effervescent. Hasil : Hasil dari uji dapat di simpulkan bahwa pada formula 3 dan 2 granul effervescent sari buah pepaya memberikan evaluasi yang lebih baik di bandingkan formula 1. Formula 3 menjadi formula granul effevescent sari buah pepaya yang paling disukai konsumen karena memiliki bau yang khas. Kesimpulan : Sari Buah Pepaya dapat diformulasi menjadi sediaan granul Effervescent. Kata Kunci : Carica papaya L, Granul effervescent, Juicer. ABSTRACT Introduction : The modern the mindset for the community was happy to be something that was practical , because of the high that the community forget in maintaining the needs of vitamins and nutrition needed body .Generally the community prefer to consume in an instant , good food or drink .Food or drink is sometimes had few vitamin needed body. Papaya fruit ( carica papaya l ) is a source of rich in nutrients as, provitamin a, carotenoid, vitamin c, vitamin b, lycopene, mineral diet and fibers food. One alternative new in fruit of the papaw increase consumption is in the form of preparations effervescent instant granule. Methoda : One fruit pepaya designed formula granule effervescent be 3 formula that f1 , f2 , and f3 done process juicer obtained juice pepaya added maltodekstrin produce of , conducted 2 phase namely the acid and the bases obtained granule phase acid and granule the bases , after both granule get mixed produce granule. Result : The results of the can be concluded that in formula 3 and 2 granule effervescent juice evaluation pepaya provide better compare formula 1. Formulas 3 be formula granule effevescent juice pepaya most favored consumers having a peculiar smell. Conclution : Papaya Fruit Essence can be formulated into EfferVescent granule preparations. Keyword : Carica papaya L, Granul effervescent, Juicer.

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Liu, Zhongbing, Xuemei Sun, Tiantian Liang, Yi Luo, Xiaoyan Chen, Ting Li, Lin Chen, et al. "Preparation and Characterization of the Biological Compound Effervescent Granule of Calcium Acetate." Current Pharmaceutical Biotechnology 20, no. 11 (September 30, 2019): 934–44. http://dx.doi.org/10.2174/1389201020666190628144637.

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Objective: Calcium acetate (Ca(CH3COO)2) is commonly used in calcium supplement for medicine, which is used as an auxiliary agent to treat osteoporosis. An effervescent granule is widely used in medical industry due to its palatability. The purpose of this study is to develop a new preparation of compound effervescent granule of the biological calcium acetate (Ca(CH3COO)2 effervescent granule), overcoming the disadvantages of the previous other dosage forms of calcium and thus enhancing the therapeutic efficacy. Methods: The biological Ca(CH3COO)2 effervescent granule was prepared by the wet granulation method. The formulation was optimized by the orthogonal experiment. The effervescent base was comprised of various amounts of citric acid and sodium bicarbonate. Other ingredients were added for optimal performance of effervescent granule. The performed Ca(CH3COO)2 effervescent granule was evaluated for the particle size, repose angle, pH value of solution, calcium acetate content and effervescence time. The in vivo effects of Ca(CH3COO)2 effervescent granule on the bone microarchitecture were investigated via Micro-CT detection, and the serum calcium level was also investigated. Results: The optimized formulation of the biological Ca(CH3COO)2 effervescent granules was composed of calcium acetate, citric acid, sodium bicarbonate, PEG6000, aspartame, PVP ethanol solution, lactose and vitamin D. Our findings reveal that this biological Ca(CH3COO)2 effervescent granule exhibited prominent effect on preventing the bone-mass loss and did better in enhancing the bone microarchitecture compared to the other calcium preparations. Conclusion: The biological Ca(CH3COO)2 effervescent granule is a novel dosage form among so many kinds of calcium preparations. It may perform better functions in the dairy calcium supplement.

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Trimedona, Neni, Rahzarni Rahzarni, and Yenni Muchrida. "KARAKTERISTIK SERBUK EFFERVESCENT DARI EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus)." LUMBUNG 20, no. 1 (February 28, 2021): 44–54. http://dx.doi.org/10.32530/lumbung.v20i1.335.

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Kulit buah naga merah kaya akan kandungan komponen aktif yang bermanfaat bagi kesehatan seperti vitamin, mineral, senyawa fenolik dan kandungan pigmen betasianin. Potensi ini dapat dikembangkan dengan mengolahnya menjadi produk pangan yang berkhasiat untuk kesehatan seperti minuman serbuk effervescent. Penelitian ini bertujuan untuk mendapatkan persentase penambahan effervescent mix (campuran asam sitrat, asam tartarat dan natrium bikarbonat) yang menghasilkan minuman effervescent dengan karakteristik yang paling baik. Kulit buah naga merah diekstrak dengan pelarut air yang diasamkan, kemudian dijadikan serbuk instan dengan metode pengeringan busa. Serbuk instan yang diperoleh dikombinasikan dengan effervescent mix dengan penambahan sebanyak 40%, 50%, dan 60% dari berat serbuk instan kulit buah naga yang digunakan. Sifat fisikokimia yang diamati adalah pH, waktu larut, kadar air, kandungan total fenol dan kadar betasianin. Dari hasil penelitian diperoleh bahwa pH serbuk effervescent berkisar antara 4,98-5,03 dengan waktu larut serbuk berkisar antara 99 - 109 detik. Kadar air terendah diperoleh pada perlakuan penambahan 50% effervescent mix yaitu sebesar 9,02%, dan kandungan total fenol tertinggi adalah 95,57 mg GAE/100g serbuk untuk perlakuan yang sama. Kadar betasianin serbuk effervescent mengalami penurunan seiring peningkatan jumlah penambahan effervescent mix.

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Ratrinia, P. W., Sumartini, and N. E. Hasibuan. "The effect of addition dfferent types of binders to the effervescent chemical characteristics of Sonneratia casolaris fruits." IOP Conference Series: Earth and Environmental Science 967, no. 1 (January 1, 2022): 012049. http://dx.doi.org/10.1088/1755-1315/967/1/012049.

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Abstract Sonneratia caseolaris fruit that has not been widely explored is as an effervescent raw material. The purpose of this study was to determine the effervescent chemical characteristics of Sonneratia caseolaris fruit with the addition of several different types of binders. The research design used in this study was a Completely Randomized Design using four treatments using different binders, namely Polyvinyl Pyrrolidone (PVP), gelatin, Pulvis Gummi Arabicum (PGA), and maltodextrin. The test method used in this research is the analysis of water content, pH value, vitamin C, antioxidants, phenols, and soluble time. Statistical analysis used was the analysis of variance (ANOVA) with a 95% confidence level. The results showed that different binders had a significantly different effect (P<0.05) on the test results for water content, pH, vitamin C, antioxidants, phenols, and soluble time. The addition of gelatin to the effervescent gave the best value on the results of the soluble time test, namely water content, antioxidants, and soluble time. Meanwhile, the addition of PGA gave the best value for the phenolic test results. The conclusion obtained from this study is that the addition of different binders can have a significantly different effect on the effervescent chemical characteristics of Sonneratia caseolaris fruit.

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Oliveira, M. S., M. P. R. Torres, A. L. Raiser, E. B. Ribeiro, C. R. Andrighetti, and D. M. S. Valladão. "Effervescent vitamin C tablets and its quality control." Scientific Electronic Archives 13, no. 5 (April 29, 2020): 73. http://dx.doi.org/10.36560/13520201055.

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Panzarini, Sônia Regina, Antônio César Perri de Carvalho, Wilson Roberto Poi, and Celso Koogi Sonoda. "Use of vitamin C in delayed tooth replantation." Brazilian Dental Journal 16, no. 1 (April 2005): 17–22. http://dx.doi.org/10.1590/s0103-64402005000100003.

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This study evaluated microscopically the effects of root surface treatment with three different solutions in delayed rat teeth replantation. Central incisors from 30 rats (Rattus norvegicus, albinus Wistar) were extracted and left on a bench for 6 h. The pulps were extirpated and root canals were irrigated with 1% sodium hypochlorite. After endodontic treatment, the root surfaces of all teeth were submitted to a 10-min treatment with 1% sodium hypochlorite, changed every 5 min. The teeth were then rinsed with saline for 10 min and assigned to 3 groups with ten specimens each. Groups I, II and III were treated, respectively, with 2% acidulated-phosphate sodium fluoride, vitamin C solution and effervescent vitamin C (2 g, Redoxon®). After root surface treatment, the teeth were filled with calcium hydroxide and replanted. The animals were sacrificed after 10 and 60 days. Group I (fluoride) presented the largest areas of replacement resorption and ankylosis. Comparing both vitamin C groups, Group III (effervescent vitamin C) yielded better results, showing more areas of ankylosis and replacement resorption than areas of inflammatory resorption.

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Broncová, Gabriela, Vadim Prokopec, and Tatiana V. Shishkanova. "Potentiometric Electronic Tongue for Pharmaceutical Analytics: Determination of Ascorbic Acid Based on Electropolymerized Films." Chemosensors 9, no. 5 (May 14, 2021): 110. http://dx.doi.org/10.3390/chemosensors9050110.

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This work deals with the design of an experimental potentiometric electronic tongue (ET) for the recognition of various samples of effervescent tablets with different ascorbic acid (vitamin C) contents. The ET consisted of twelve potentiometric sensors based on conductive polymers, which were derived from 4-amino-2,1,3-benzothiadiazole, 3,4-diaminobenzoic acid, and neutral red on the surface of the platinum electrode using cyclic voltammetry. The aim of the potentiometric study was to assess the influence of the vitamin C content and the composition of the matrix of commercial samples on the potentiometric response. The results obtained from the sensor array proved that the stability of the potentiometric signal and the accuracy of measurements are affected by individual sensors. The identification of the vitamin C content in the individual samples of effervescent tablets obtained by means of the potentiometric electronic tongue corresponded with the results of the coulometric titration.

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Jeong, Moon-Jin, Myoung-Hwa Lee, Soon-Jeong Jeong, So-Jeong Kim, Myeong-Ji Ko, Hye-Won Sim, Ju-Young Lee, Ae-Jung Im, and Do-Seon Lim. "Effect of Commercial Effervescent Vitamin Tablets on Bovine Enamel." Journal of Dental Hygiene Science 19, no. 4 (December 31, 2019): 261–70. http://dx.doi.org/10.17135/jdhs.2019.19.4.261.

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Tölgyesi, Ádám, Evelin Girincsi, Viktória Hermann, Andrea Simon, and Mária Bálint. "Determination of fat-soluble vitamins A, D2, D3, E and K3 by isotope dilution and LC-MS/MS instrument assembly." Élelmiszervizsgálati Közlemények 68, no. 3 (2022): 3994–4005. http://dx.doi.org/10.52091/evik-2022/3-2-eng.

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The purpose of our publication is the determination of the total amount (of natural origin and added) of fat-soluble vitamins A, D2, D3 and E in low amounts in foods (wheat flour, soft drinks, effervescent tablets) and dietary supplements using a liquid chromatography tandem mass spectrometry (LC-MS/MS) method. The samples were diluted with isotope-labeled derivatives of the target components (vitamin A-d6, vitamin D2-d3, vitamin D3-d3, vitamin E-d6), and after extraction and saponification, they were purified by liquid-liquid extraction. After a solvent exchange, the concentration of the vitamins was determined on a C8 HPLC column using acidic mobile phases (0.1% formic acid in water/methanol) and LC-MS/MS technique. In dietary supplements, the analysis of the fat-soluble vitamin K3 may also be important, because the use of vitamin K3 is currently not approved in human formulations. During the determination of vitamin K3, saponification is not necessary, due to its structure, alkaline hydrolysis would lead to the decomposition of vitamin K3, so this component was analyzed by a method different from the one used for the other vitamins. LC-MS/MS analysis of small amounts of vitamin K3 is more complicated than that of other vitamins due to the low sensitivity of the MS instrument to vitamin K3. The determination of vitamin K3 was therefore carried out after chemical derivatization with L-cysteine as a derivatizing reagent, also with isotope dilution and LC-MS/MS technique. After intralaboratory validation, the methods were successfully used in domestic and international proficiency tests in infant formulas and liquid vitamin preparations.

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Kova´cs-Hadady, Katalin, and Istva´n Fa´bia´n. "Determination of vitamin C in effervescent tablets containing other vitamins together with trace elements." Journal of Pharmaceutical and Biomedical Analysis 14, no. 11 (August 1996): 1479–86. http://dx.doi.org/10.1016/0731-7085(96)01786-4.

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Purbowati, I. S. M., A. Maksum, and R. Anggriawan. "Effervescent formulation based on variation of nanocapsules matrix type and roselle (Hibiscus sabdariffa) nanocapsules percentage." Food Research 5, no. 3 (May 10, 2021): 53–59. http://dx.doi.org/10.26656/fr.2017.5(3).299.

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Roselle flowers are usually consumed in the form of fresh steeping. To increase the flexibility of using roselle, effervescent roselle-based products are made which of course more practical, efficient and attractive. Unfortunately, the bioactive compound in roselle extracts is not stable to environmental influences so nanoencapsulation technology needs to be done. The encapsulation matrix type gives a unique effect on each core. The purposes of this study were to determine the effects of variation in the matrix types and percentage of roselle nanocapsules on the physical and chemical effervescent properties. The research design used in this study was a Complete Random Design with 2 factors and 3 replications. The first factor comprised matrix types (A): maltodextrin (A1) and Arabic gum (A2). The second factor was roselle nanocapsule percentages (B): 10% (B1), 15% (B2) and 20% (B3). Observed variables in this study were total phenol, anthocyanin, vitamin C, antioxidant activity and dissolving time. The Arabic gum nano encapsulated matrix type gave a better value of Vitamin C, antioxidant activity and dissolving time than maltodextrin, namely 0.149±0.049 µg/3 g, 34.02±4.52%, 2.93±0.80 mins. The percentage of roselle nanocapsules by 20% gave the highest vitamin C value, namely 0.188±0.032 µg /3 g. The best treatment combination was obtained from the treatment (A2B3) Arabic gum nanocapsules using the third percentage (20%) with the characteristics: total phenol content 4.17 µg /3 g, anthocyanin 0.070 µg /3 g, vitamin C 0.188 µg /3 g when it dissolves in 1.25 mins.

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Hiola, Reni, and Robert Tungadi. "DEVELOPMENT OF EFFERVESCENT GRANULE OF CORN MILK, SUPPLEMENTED WITH PROBIOTICS LACTOBACILLUS STRAIN SHIROTA." International Journal of Applied Pharmaceutics 10, no. 5 (September 8, 2018): 71. http://dx.doi.org/10.22159/ijap.2018v10i5.27459.

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Objective: One of the materials which can be formulated into probiotics drink is corn milk. It has nutrient contents such as vitamin A, B, C, minerals, and fibres. The objective of this study was to develop and evaluate the probiotic drink of corn milk which was formulated into an effervescent granule.Methods: The first step was carried out to make corn extract with the addition of Lactobacillus strain Shirota and incubated 24 h at 40 °C to gain corn milk. After that, corn milk was centrifuged to get filtrate and dried by oven 40 °C for 2 d to gain dry powder. Then corn milk powder was formulated into effervescent granule (3 formulas) using different ratio of acids. The method which used in making effervescent granule of corn milk was wet granulation. All formulas were done evaluations including physical and chemical properties of granule and hedonic test.Results: The results showed that formula 1 (only citric acid 23.84%) gave unsatisfactory results particularly on the evaluation tests such as LOD 9.64%, dissolution time 3.25 min, moisture content 10.67% and hedonic test which did not meet the requirements. Otherwise, formula 2 (only tartaric acid 23.84%) and formula 3 (citric acid 7.94% and tartaric acid 15.9% combination) showed satisfactory results for all evaluation tests of granules. Particularly formula 3 gave pH 5 on pH test which was the same as pH lactic acid for fermentation and LOD 4.34%, MC 4.53%, ρb 0.53 g/ml, ρt 0.62 g/ml and hedonic test around 80%.Conclusion: Formula 3 was the best formulation based on the evaluation and the stability of corn milk effervescent granule.

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XU, Jian, and Yan LI. "The formulation and preparation technology of aspirin and vitamin C effervescent tablets." Pharmaceutical Care and Research 12, no. 2 (April 2012): 129–31. http://dx.doi.org/10.5428/pcar20120218.

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Permana, Benny, Debora Ronauli, and Ilma Nugrahani. "Development and Validation of Spectrofluorometric Method for the Determination of Ascorbic Acid in Several Dosage Forms by Using Methylene Blue." Acta Pharmaceutica Indonesia 46, no. 1 (June 30, 2021): 1–6. http://dx.doi.org/10.5614/api.v46i1.14917.

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Ascorbic acid or vitamin C is one of the most widely consumed supplement and available at the market in several preparations such as tablet, sweetlet, effervescent tablet, and ready to drink product. Spectrofluorometric method has been developed in this study for quantitative determination of ascorbic acid in various forms of products based on the reaction between ascorbic acid and methylene blue. Methylene blue concentration decreased along with the addition of ascorbic acid due to a redox reaction which caused the formation of colorless leuco-methylene blue and dehydroascorbic acid. The fluorescence intensity of methylene blue was measured at excitation and emission wavelengths of 664 nm and 686 nm respectively. The proposed method was found to have a good selectivity, linearity, accuracy, and precision. Validation studies demonstrated a good linearity for the method with a correlation coefficient > 0.999 and Vx0 < 2%. The accuracy test also met the requirements with the recoveries were not less than 90.0% and not more than 110.0%. Precision test gave a relative standard deviation (% RSD) not more than 2%. The ascorbic acid content in several marketed products was evaluated by this new spectrofluorometric method and the result was in good agreement for effervescent tablet, isotonic drink and lozenges with the label claim and specification. Due to its simplicity, the method can be used to analyze vitamin C in different product forms.

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E. Rech, Andrea, Cristina P. Farina, Pamela C. Lukasewicz Ferreira, and Diogo Miron. "DETERMINATION OF ARGININE AND ASCORBIC ACID IN EFFERVESCENT TABLETS BY MULTIDIMENSIONAL CHROMATOGRAPHY." Drug Analytical Research 1, no. 2 (December 28, 2017): 44–52. http://dx.doi.org/10.22456/2527-2616.79222.

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This paper describes a fast and direct method for quantification of arginine and ascorbic acid (vitamin C) in effervescent tablets. HPLC-UV multidimensional chromatography (RP18 and cyanopropyl columns) was developed and validated. Phosphate buffer 10 mMpH 3.4 was used as mobile phase. Satisfactory resolution between the drugs was obtained with analysis time less than 8.0 min. Method was linear in the ranges of 140-320 mg.mL-1 and 240-560 mg.mL-1 for arginine and ascorbic acid, respectively. Precision showed RSD <2.0%. Recovery was 99.5% and 100.0% for arginine and ascorbic acid, respectively. Robustness was confirmed through factorial analysis 22 (pH and mobile phase flow rate as factors).

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Faisal, Abdu. "Formulation by design approach for effervescent granules of vitamin C using statistical optimization methodologies." Journal of Applied Pharmaceutical Research 8, no. 4 (November 11, 2020): 62–69. http://dx.doi.org/10.18231/j.joapr.2020.v.8.i.4.62.69.

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Sihomning, Christina, and Vivi Eulis Diana. "Formulasi Sediaan Serbuk Effervescent Sari Buah Jambu Biji (Psidium Guajava)." Jurnal Dunia Farmasi 1, no. 1 (May 14, 2019): 7–14. http://dx.doi.org/10.33085/jdf.v1i1.4346.

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Pendahuluan: Jambu biji (Psidium guajava) merupakan salah satu tanaman yang sudah lama dimanfaatkan sebagai tanaman obat. Buah jambu biji mengandung beta karoten dan vitamin Cyang tinggi sehingga dapat meningkatkan daya tahan tubuh dan menyembuhkan sariawan, jambu biji mengandung zat non-gizi yang tinggi dan kaya akan serat pangan. Tujuan: dari penelitian ini untuk mengetahui apakah sari buah jambu biji dapat diformulasikan dalam bentuk sediaan serbuk effervecent. Metode: Penelitian ini menggunakan metode eksperimental, formulasi sediaan serbuk effervecent yang terdiri dari berbagai komposisi diantaranya asam sitrat, asam tartrat, natrium bikarbonat, laktosa, dan serbuk kering sari buah jambu biji. Pengujian terhadap sediaan serbukeffervecent dari sari buah jambu biji meliputi pengujian waktu dispersi, pH dan pengujian hedonik. Hasil: Uji waktu dispersi pada sediaan serbuk effervecent sari buah jambu biji menunjukkan waktu dispersi yang baik, dimana semua sediaan larut sempurna dalam waktu kurang dari 52-59 detik, dimana formula I memiliki waktu dispersi tercepat yaitu 28,29 detik, formula II dengan waktu 31,58 detik, dan formula III dengan waktu dispersi terlama yaitu 34,08 detik. Pada pengujian pH serbuk effervecent sari buah jambu biji didapatkan pH masing-masing produk dengan jumlah, formula I dengan pH 4,6 dan formula II pH 4,7 sedangkan formula III 4,8. Pada pengujian hedonik yaitu atribut rasa menunjukkan formula III rasa terlalu asam, Formula II memiliki rasa tidak terlalu asam, dan Formula I memiliki rasa lebih manis. Kesimpulan :Sari buah jambu biji (Psidium guajava) dapat diformulasikan kedalam bentuk sediaan serbuk effervecent. Disarankan kepada peneliti selanjutnya untuk membuat sediaan serbuk effervecent sari dari sari buah lainnya.

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Lötter, A. P., M. M. De Villiers, J. S. Handford, and W. Liebenberg. "Identification and Prevention of Insoluble Reaction Products Forming after Dissolution of Effervescent Multi-Vitamin Tablets." Drug Development and Industrial Pharmacy 21, no. 17 (January 1995): 1989–98. http://dx.doi.org/10.3109/03639049509065883.

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Vlachou, Marilena, Angeliki Siamidi, Natassa Pippa, and Nikolaos Fikioris. "Vitamin C Fast Action Tablets by Doctor's Formulas' Food Supplements: Evaluation of Matrix Properties." Advanced Science, Engineering and Medicine 11, no. 11 (November 1, 2019): 1111–14. http://dx.doi.org/10.1166/asem.2019.2451.

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Vitamin C (ascorbic acid) is a diet dependent vitamin that promotes antioxidation though free radical scavenging and electron donation, has anti-inflammatory properties, supports growth of healthy immune cells and enhances bioavailability of iron in hemoglobin. Vitamin C as a food supplement is commercially available in many forms like immediate/extended release, effervescent and chewable tablets. Its absorption from a solid dosage form after oral administration depends on the release of the active ingredient from the product under physiological conditions and the permeability across the gastrointestinal tract. Generally, immediate release formulations provide rapid drug absorption and consequently a quick onset of the therapeutic effect. The aim of this study was to examine whether the physicochemical properties of the excipients, present in the solid pharmaceutical formulation under study, promote a synergistic interaction with the stereoelectronic features of ascorbic acid, so that the latter is released into the gastric-like dissolution environment in 30 minutes, thus ensuring fast onset of action. Vitamin C fast action tablets by Doctor's Formulas' Food Supplements were evaluated regarding their tablets' properties. Uniformity of tablets regarding their weight, thickness, friability, hardness, disintegration and dissolution was achieved. The careful choice of the appropriate type and quantity of excipients (calcium phosphate, corn starch, silicon dioxide, maltodextrin and magnesium stearate) in the tablet formulation, along with the application of the suitable compression force, ensures right handling/packaging and safe transportation. Moreover the disintegration time as well as the dissolution profile matched the requirements needed for immediate release formulations.

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MEURMAN, J. H., and H. MURTOMAA. "Effect of effervescent vitamin C preparations on bovine teeth and on some clinical and salivary parameters in man." European Journal of Oral Sciences 94, no. 6 (December 1986): 491–99. http://dx.doi.org/10.1111/j.1600-0722.1986.tb01791.x.

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Ribeiro, Danilo Braga, Gabriela Santos Silva, Djanira Rubim dos Santos, Andressa Rose Castro Costa, Eliane Braga Ribeiro, Mihaela Badea, and Gilvanda Silva Nunes. "Determination of the Antioxidant Activity of Samples of Tea and Commercial Sources of Vitamin C, Using an Enzymatic Biosensor." Antioxidants 10, no. 2 (February 22, 2021): 324. http://dx.doi.org/10.3390/antiox10020324.

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Antioxidants are synthetic or natural compounds capable of preventing or delaying oxidative damage caused by chemical species that can oxidize cell biomolecules, such as proteins, membranes, and DNA, leading to the development of various pathologies, such as cancer, atherosclerosis, Parkinson, Alzheimer, and other diseases serious. In this study, an amperometric biosensor was used to determine the antioxidant activity of teas and effervescent products based on vitamin C, available on the market. A sensor composed of three electrodes was used. The performance of the following electrochemical mediators was evaluated: meldola blue combined with Reineck salt (MBRS), Prussian blue (PB), and cobalt phthalocyanine (CoPC), as well as the time of polymerization in the enzymatic immobilization process and the agitation process during chronoamperometric measurements. Prussian blue proved to be more efficient as a mediator for the desired purposes. After optimizing the construction stages of the biosensor, as well as the operational parameters, it presented stability for a period of 7 months. The results clearly indicate that the biosensor can be successfully used to detect fraud in products called “antioxidants” or even in drugs containing less ascorbic acid than indicated on the labels. The detection limit was set at 4.93 µmol·L−1.

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Khan, Mohammad Rizwan, Zeid Abdullah Alothman, Mu Naushad, Ayman Abdul Ghfar, and Saikh Mohammad Wabaidur. "SIMULTANEOUS ANALYSIS OF VITAMIN C AND ASPIRIN IN ASPIRIN C EFFERVESCENT TABLETS BY HIGH PERFORMANCE LIQUID CHROMATOGRAPHY–PHOTODIODE ARRAY DETECTOR." Journal of Liquid Chromatography & Related Technologies 35, no. 17 (January 2012): 2454–61. http://dx.doi.org/10.1080/10826076.2011.633679.

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Dobrovolskaya, O. V., N. V. Demin, A. V. Smirnov, and N. V. Toroptsova. "Bone mineral density status and the need for anti-osteoporotic therapy in postmenopausal women with systemic scleroderma." Medical Council, no. 9 (June 12, 2019): 72–79. http://dx.doi.org/10.21518/2079-701x-2019-9-72-79.

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The article is devoted to the study of bone mineral density in patients with systemic scleroderma (SSD) and the identification of persons, who needs the anti-osteoporotic treatment. A total of 170 postmenopausal women were examined: 103 patients with SSD and 67 patients without inflammatory rheumatic diseases. Osteoporosis (OP) was detected in 49.5% in the patient group and in 31% in the control group (p <0.05). The correlation relation between the bone mineral density (BMD) and body mass index was found to be direct, and the one between BMD and the duration of the disease and the cumulative dose of glucocorticoids was found to be inverse. The blood vitamin D level (25(OH)D) was significantly lower in patients than in controls (19.3 ± 7.4 ng/ml and 23.3 ± 8.6 ng/ml, respectively), and among individuals with SSD it was significantly lower in patients with OP than in patients without OP (p <0.05). 85% examined patients with SSD needed the anti-osteoporotic therapy. Treatment with the generic alendronate in the form of effervescent tablets to prepare Binosto buffer solution was effective and safe in patients with SSD with esophageal hypotension.

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Tashkhourian, Javad, Hamed Valizadeh, and Abdolkarim Abbaspour. "Ascorbic Acid Determination Based on Electrocatalytic Behavior of Metal-Organic Framework MIL-101-(Cr) at Modified Carbon-Paste Electrode." Journal of AOAC INTERNATIONAL 102, no. 2 (March 1, 2019): 625–32. http://dx.doi.org/10.5740/jaoacint.18-0135.

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Abstract Background: Metal-organic frameworks (MOFs) are classified as microporous materials. They have large surface areas, low framework densities, accessible cages, and tunnels with modifiable pores. Objective: The MOF MIL-101(Cr) with a large pore volume was synthesized hydrothermally and used in the electrochemical reactions as an electrocatalyst for the determination of ascorbic acid (AA). The synthesized MOF was characterized by scanning electron microscopy and X-ray powder diffraction. Methods: The electrocatalytic behavior of a carbon-paste electrode modified with MIL-101(Cr) was studied through electro-oxidation of AA by cyclic voltammetry and square wave voltammetry. The conventional three-electrode cell system, consisting of Ag/AgCl (3 M KCl) as thereference, platinum wire as the counter electrode, and modified carbon paste as the working electrode,was used in the experiment. Results: Under optimized experimental conditions, the electrode revealed a linear relationship between the oxidation peak current and concentration of AA over a wide range from 0.01 to 10 mM with the LOD of 0.006 mM (3 Sb/m). The results showed that 100-fold ofNa+, K+, Mg2+, Ca2+, Cl−, SO42−, sorbitol, sucrose, fructose, citric acid, 40-fold of NO3−, glucose, sucrose, urea, and 10-fold of uric acid had no significant interference. The method was adapted for the determination of the concentration of AA present in two real samples (vitamin C tablet and vitamin C effervescent tablet) with recovery of 97.0 and 96.0%, respectively. Conclusions: A simple, sensitive and reliable modified electrode has been established and applied for the determination of AA. Highlights: The modified electrode represented a good performance in the analysis of the real sample.

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Soleymani, Bahram, Behrooz Zargar, and Saadat Rastegarzadeh. "Separation and pre-concentration of Sunset Yellow in beverages and effervescent vitamin C tablets by a new flotation technique prior to spectrophotometric determination." Food Additives & Contaminants: Part A 36, no. 11 (August 26, 2019): 1605–15. http://dx.doi.org/10.1080/19440049.2019.1657965.

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Perrin, Germain, Sarah Berdot, Frédérique Thomas, Bruno Pannier, Nicolas Danchin, Pierre Durieux, and Brigitte Sabatier. "Evaluation of exposure to effervescent drugs in a large health check-up population in France: a cross-sectional study." BMJ Open 8, no. 7 (July 2018): e022368. http://dx.doi.org/10.1136/bmjopen-2018-022368.

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ObjectivesThe relationship between high dietary sodium intake and hypertension is well established. Some drugs are associated with high-sodium content, particularly effervescent tablets (ETs). Despite a possible cardiovascular risk associated with the use of such drugs, observational data describing exposure to ETs in ambulatory subjects are lacking.This study aims to estimate the prevalence of exposure to ETs and to highlight factors associated with this exposure in a large French health check-up population.DesignThis was a cross-sectional study.Setting and participantsParticipants were French individuals who underwent medical check-ups at the Investigations Préventives et Cliniques centre between April and June 2017.ResultsIn total, 1043 subjects were included in the study. The prevalence of exposure to ETs in the last 30 days was 26.9% (95% CI 24.2% to 29.6%). Exposure was frequent (ie, two ETs per week or more in the last 30 days) for 7.3% of subjects. Self-medication was the major source of exposure (93.8%). Paracetamol, aspirin, vitamins and betaine accounted for 95.3% of the ETs used. The factors associated with this exposure by multivariate analysis were: male gender, Overseas French origin, depression and body mass index ≥25 kg/m2. A diagnosis of hypertension or treatment with diuretics were not protective factors against exposure to ETs.ConclusionExposure to ETs is frequent in the general population, particularly through self-medication. Clinical conditions associated with low-salt requirements were not associated with lower exposure to ETs, suggesting a lack of awareness by practitioners and patients about this iatrogenic issue.

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Listov, Konstantin N., and Roman A. Yakovlev. "Development of the composition and technology of effervescent tablets for the prevention of cerebral circulation disorders in the elderly." Russian Military Medical Academy Reports 40, no. 2 (July 14, 2021): 77–82. http://dx.doi.org/10.17816/rmmar77854.

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Increasing the level of antioxidants in the human body plays an important role in increasing longevity. Studies on small laboratory animals showed that in the main group with an increased content of antioxidant enzymes, life expectancy was 20% higher than in the comparison group with age and heart diseases. Thus, the hypothesis is confirmed that a high content of active free radical molecules causes aging and the data obtained on small laboratory animals will increase the human lifespan. This fact is associated with the occurrence of heart and oncological diseases, as well as other age-related pathologies. In order to prevent the development of the above diseases, a drug was developed with an innovative composition of complex-compatible components. The experimental drug contains substances with an increased content of antioxidants for the prevention of cerebrovascular accidents, such as dihydroquercetin and black grape extract. And also vitamins and amino acids: succinic acid, ascorbic acid, glycine. The choice of the composition of the experimental drug was carried out on the basis of the antioxidant properties of these groups of substances, which are widely known, and their combined use will become a potentiated synergy of the selected components and complement their effect. Due to the fact that the classical technology for the production of effervescent dosage forms does not allow combining the components of the composition of the experimental drug, the task of developing an individual technology for combining the acid and alkaline fractions of the formulation by separating the components at the stage of the technological process of drying the raw material was solved. Thanks to this, it became possible to separate the granulation of acid and alkaline components, which made it possible to stabilize the tabletting mixture (3 tables, bibliography: 8 refs.).

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Nsengiyumva, C., J. O. De Beer, W. Van de Wauw, A. J. Vlietinck, and F. Parmentier. "An exprimental design approach to selecting the optimum liquid chromatographic conditions for the determination of vitamins B1, B2-phosphate, B3, B6 and C in effervescent tablets containing saccharin and sunset yellow FCF." Chromatographia 44, no. 11-12 (June 1997): 634–44. http://dx.doi.org/10.1007/bf02466667.

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Murdinah, M. "The Use of Alginate in Lemon Extract Effervescent Powder Production." Jurnal Pengolahan Hasil Perikanan Indonesia 18, no. 2 (November 25, 2015). http://dx.doi.org/10.17844/jphpi.v18i2.10619.

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Study on the use of alginate in lemon (Citrus medica var lemon) extract effervescent powder production has conducted. The aims of the research are to determine the optimum concentration of alginate used in lemon extract effervescent powder to produced best product and acceptance consumen.The lemon extract effervescent powder formula consisted of lemon extract powder, sucrose, aspartame, salt and effervescent mix (citric acid-tartrat acid-sodium bicarbonat). The alginate used in this study was extracted from Sargassum filipendula sea weed. The concentration of alginate used in lemon effervescent powder production was varied from 1; 2; 3 and 4%. The parameters observed to see the quality of the product were moisture content, ash content, pH, viscosity and organoleptic of dietary fiber, sugar content, vitamin C content, total titratable acids, TPC and E.Coli to the best product. The result showed that the higher the concentration of alginate used in lemon effervescent powder production, the higher viscousness and the lower the organoleptic value. The optimum concentration of alginate used in the lemon extract effervescent powder processing was 1%. The characteristic this product 7.60% moisture content, 0.86% insoluble dietary fiber , 7.92% soluble dietary fiber, 3.74% sugar content, 55,26 mg/100 g vitamin C, 134.15 mL 0.1 NaOH/100 mL total titratable acids, 20 cPs viscosity, <2.5x102 coloni/mL TPC and E.Coli negative. Keywords: Alginate, characteristic, effervescent powder, lemon extract

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Mahesh B., Bagul, and Surawase Rajendra K. "Development of Zinc Gluconate Vitamin C Effervescent Tablet for Immunity Improvement and Management of COVID-19." Research Journal of Pharmaceutical Dosage Forms and Technology, November 12, 2022, 299–303. http://dx.doi.org/10.52711/0975-4377.2022.00049.

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This look at aimed to increase the system of effervescent tablet containing zinc Gluconate and Ascorbic acid (vit c) combination to increase immunity and likely through reducing viral load and improving immunity of the patients. In this examine the formula turned into calculated exactly and then prepared by way of two distinct srtategies for compression and assessment. The flowability of powder and grannules turned into investigated effervescent tablet were produced by way of direct compression and wet granulation approach. The produced tablet have been then evaluated for appropriate hardness, friability ˂1%, effervescent time ˂ 3 minutes, solution PH ˂6, water content ˂ 0.5% and most beneficial content uniformity. The powder aggregate prepared for the direct compression technique had acceptable flowability however required a excessive compression force. Flowability and different physicochemical properties of this powder. Including compressibility and hardness have been progressed with the aid of granulation. The result of effervescent tablet produced by way of the moist granulation technique, which incorporate a higher percent of granulated content material have been higher than other method. The PVP-K30 binder solution is suitable to produced bubbling granules which are compressed into tablet, because of improvement in flowability and compactibility.

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Zubaydah, Wa Ode Sitti, Wa Fia, Sitti Adawia, N. Novitasari, R. Rahmasari, and Dhidi Dharmadi Hasanuddin. "Formulasi Minuman Effervescent Mix Serbuk Daun Kelor (Moringa oleifera)." Pharmauho: Jurnal Farmasi, Sains, dan Kesehatan 4, no. 2 (April 21, 2019). http://dx.doi.org/10.33772/pharmauho.v4i2.6281.

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Sehat merupakan salah satu tujuan yang hendak dicapai oleh semua orang. Di Indonesia, terdapat tanaman yang mengandung banyak manfaat bagi kesehatan masyarakat dan mengandung zat gizi yang sangat tinggi mulai dari zat gizi makro hingga zat gizi mikro. Tanaman tersebut adalah Moringa oleifera atau yang lebih sering disebut pohon kelor oleh masyarakat Indonesia. Namun, tidak banyak orang mengetahui akan manfaat-manfaat pohon kelor sehingga pemanfaatannya masih sangat rendah di masyarakat. Salah satu manfaat yang dapat diambil dari pohon kelor terdapat pada daunnya. Daun kelor merupakan salah satu bagian dari tanaman kelor yang telah banyak diteliti kandungan gizi dan kegunaannya. Penelitian lain menyatakan bahwa menunjukkan bahwa daun kelor mengandung vitamin C setara vitamin C dalam 7 jeruk, vitamin A setara vitamin A pada 4 wortel, kalsium setara dengan kalsium dalam 4 gelas susu, potassium setara dengan yang terkandung dalam 3 pisang, dan protein setara dengan protein dalam 2 yoghurt. Daun kelor merupakan tanaman lokal yang mengandung zat gizi yang tinggi, namun pemanfaatannya sebagai bahan pangan masih sangat rendah. Agar zat gizi yang terkandung dalam daun kelor dapat dimanfaatkan tubuh, maka perlu diolah menjadi minuman yang digemari oleh masyarakat seperti minuman effervescent dengan sensasi rasa yang menyegarkan di mulut.Kata kunci: kelor, serbuk, nutrisi, effervescent

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Putri, Nurwigya Mohamad, Nangsih Sulastri Slamet, Prisca Safriani Wicita, and Arlan K. Imran. "GRANUL EFFERVESCENT KOMBINASI BUNGA TELANG (Clitoria ternatea) DAN JERUK KALAMANSI (Citrus microcarpa) SEBAGAI ALTERNATIF MINUMAN KESEHATAN." Journal of Experimental and Clinical Pharmacy (JECP) 1, no. 1 (February 2, 2021). http://dx.doi.org/10.52365/jecp.v1i1.196.

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Bunga telang (Clitoria ternatea) adalah tanaman yang memiliki potensi farmakologis sebagai antioksidan, antimikroba, antiparasit, anti-inflamasi, antikanker, antihistamin. Jeruk kalamansi (Citrus microcarpa) merupakan tanaman yang sangat kaya akan mineral dan vitamin C sehingga sangat baik digunakan untuk bahan baku minuman kesehatan. Sediaan granul effervescent adalah hasil dari gabungan senyawa asam dan basa yang bila ditambahkan dengan air (H2O) akan bereaksi melepaskan karbon dioksida (CO2), sehingga efek ini akan menghasilkan buih pada sediaan. Tujuan dari penelitian ini adalah untuk memanfaatkan bunga telang dan jeruk kalamansi sebagai bahan aktif dan untuk menghasilkan sediaan granul effervescent sebagai alternatif minuman kesehatan. Ekstrak bunga telang diperoleh dari metode ekstraksi sederhana dengan cara diblender menggunakan air (1:3). Sari jeruk kalamansi diperoleh dari perasan buahjeruk kalamansi. Hasil penelitian menunjukkan bahwa sediaan granul effervescent kombinasi bunga telang dan jeruk kalamansi ini memiliki warna granul putih keunguan dan larutan biru muda bening serta memiliki bau dan rasa kombinasi bunga telang dan jeruk kalamansi, waktu dispersi yang memenuhi persyaratan waktu larut yakni 1 menit 4 detik dan indeks kompresibilitas 13,3%. Berdasarkan penilaian panelis dari parameter tekstur, warna, aroma dan rasa menunjukkan rata-rata 4,3 dengan kategori suka.Kata Kunci : Bunga telang, Jeruk kalamansi, Granul effervescent

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Lestari, Diah Dwi, Arief Rakhman Affandi, Endang Is Retnowati, and Iffah Muflihati. "FORMULASI PEMBUATAN TABLET EFFERVESCENT MENGGUNAKAN EKSTRAK KUNYIT DENGAN PENAMBAHAN VITAMIN C." Jurnal Teknologi Pangan 15, no. 2 (December 31, 2021). http://dx.doi.org/10.33005/jtp.v15i2.2945.

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Thoke, Sagar B., Yogesh P. Sharma, Swati S. Rawat, and Satish L. Nangude. "FORMULATION DEVELOPMENT & EVALUATION OF EFFERVESCENT TABLET OF ALENDRONATE SODIUM WITH VITAMIN D3." Journal of Drug Delivery and Therapeutics 3, no. 5 (September 15, 2013). http://dx.doi.org/10.22270/jddt.v3i5.623.

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A. U., Gayke. "DESIGEN, FORMULATION AND EVALUATION OF EFFERVESCENT TABLET OF ALENDRONATE SODIUM WITH VITAMIN D3." World Journal of Pharmacy and Pharmaceutical Sciences, September 1, 2017, 2034–40. http://dx.doi.org/10.20959/wjpps20179-10155.

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Dalmaz, Aslihan, and Sezen Sivrikaya Özak. "Green deep eutectic solvent assisted liquid–liquid microextraction procedure for Sunset Yellow dye in effervescent vitamin C tablets." Journal of the Iranian Chemical Society, January 4, 2022. http://dx.doi.org/10.1007/s13738-021-02454-y.

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Dinc, Erdal, and Dumitru Baleanu. "Ratio Spectra-Continuous Wavelet Transform and Ratio Spectra-Derivative Spectrophotometry for the Quantitative Analysis of Effervescent Tablets of Vitamin C and Aspirin." Revista de Chimie 59, no. 5 (June 9, 2008). http://dx.doi.org/10.37358/rc.08.5.1817.

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Simultaneous spectrophotometric analysis of tablets and binary mixtures containing vitamin C (VC) and aspirin (ASP) with overlapping spectra was performed by ratio spectra-continuous wavelet transform (RS-CWT) and ratio spectra-derivative spectrophotometry (RS-DS). In the application of RS-CWT and RS-DS to the simultaneous analysis of VC and ASP no separation step was considered. The basis of RS-CWT and RS-DS approaches is the transformation and the derivation of the ratio spectra of the related compounds and their samples. Calibration graphs in the linear concentration range 4-20 mg/mL for both compounds were obtained by measuring the CWT and first derivative amplitudes at 260.8 nm for VC and 234.6 nm for ASP in the BIOR-CWT spectra and at 256.0 nm for VC and 230.7 nm for ASP in the first derivative of ratio spectra, respectively. Both methods were tested by using the synthetic mixtures and standard addition technique, and were applied to the simultaneous determination of VC and ASP in commercial effervescent tablets and a good coincidence was reported for experimental results obtained by the proposed RS-CWT and RS-DS.

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Thi Ngan, Dang, Bui Mai Ngoc, Ha Thi Thanh Huong, and Nguyen Thi Hai Yen. "Preparation of Green Tea Effervescent Tablets." VNU Journal of Science: Medical and Pharmaceutical Sciences 36, no. 3 (September 25, 2020). http://dx.doi.org/10.25073/2588-1132/vnumps.4258.

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This study aims to prepare green tea effervescent tablets with high EGCG content to retain the antioxidant and antibacterial effects of green tea as well as to diversify green tea product lines. The green tea effervescent tablets, prepared in the study by the method of wet granulation and stamping, met the general quality standards for effervescent tablets according to Vietnam Pharmacopeia V with the content of EGCG, quantified by HPLC, reaching 8.423 ± 0.023%. Keywords Green tea, effervescent tablets, epigallocatechin gallate, HPLC. References [1] Do Tat Loi, Vietnamese medicinal plants andherbs, Thoi Dai Publishing House, Vietnam, 2013, pp. 187-188.[2] Shutsung Liao, Yung-hsi Kao, Richard A.Hiipakka, Green Tea: Biochemical and Biological Basis for Health benefits, Vitamins and Hormones. 62 (2001) 09-61. https://doi.org/10.1016/s0083-6729(01)62001-6.[3] Shuichi Masuda, Yuko Shimamura, Colin R. Martin, Effect of Green Tea on Nitrosamines: Implications for Cancer, Tea in health and disease prevention. 68 (2013) 813-820. https://doi.org/10.1016/C2010-0-64948-0[4] Richard S. Bruno, Joshua A. Bomser, Mario G. Ferruzzi, Antioxidant capacity of Green tea (Camellia sinensis). 4 (2014) 33-39. https://doi.org/10.1016/B978-0-12-404738-9.00004-0. [5] C.J. Chang et al, Separation of catechins from green tea using carbon dioxide extraction, Food chemistry. 68 (1) (2000) 109-113. https://doi.org/10.1016/S0308-8146(99)00176-4[6] M.E. Harbowy et al, Tea chemistry, Critical reviews in plant sciences. 16 (5) (1997) 415-480. https://doi.org/10.1080/07352689709701956[7] Le Quan Nghiem, Huynh Van Hoa, Preparation and biopharmaceutical, Hanoi Education Publishing House, Vietnam, 2007, pp. 194-200.[8] S. Taymouri et al, Formulation and optimization of effervescent tablet containing bismuth sub-citrate, Journal of Reports in Pharmaceutical Sciences. 8 (2) (2019) 236. https://doi.org/10.4103/jrptps.JRPTPS_11_19[9] A. Aslani et al, Formulation, characterization and physicochemical evaluation of potassium citrate effervescent tablets, Advanced pharmaceutical bulletin. 3 (1) (2013) 217. https://doi.org/10.5681/apb.2013.036[10] Herbert A Liberman, Leon Lachman, Joseph B. Schwartz, Effervescent tablets, Pharmaceutical dosage form: Tablets. 1 (2005) 285-302. https://doi.org/10.1002/jps.2600790225[11] Ministry of Health Portal, Vietnam pharmacopeia V, Medical Publishing House, Vietnam, 2018.[12] I.H.T. Guideline, Validation of analytical procedures: text and methodology Q2 (R1), International conference on harmonization, Geneva, Switzerland, 2005.[13] A. Bradfleld et al,The catechins of green tea. Part I, Journal of the Chemical Society (Resumed). (1947) 32-36.[14] M.J. Lee. et al, Pharmacokinetics of tea catechins after ingestion of green tea and (−)-epigallocatechin-3-gallate by humans: formation of different metabolites and individual variability, Cancer Epidemiology and Prevention Biomarkers. 11 (10) (2002) 1025-1032.

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Journal articles on the topic 'Vitamin effervescent'

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