Journal articles on the topic 'Vitamin D'
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Köse, Nurgül. "Blood vitamin D levels in patients with fibromyalgia and the effectiveness of vitamin D treatment." Dicle Medical Journal/Dicle Tıp Dergisi 40, no. 4 (January 12, 2013): 585–88. http://dx.doi.org/10.5798/diclemedj.0921.2013.04.0337.
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J. Mustafa, Awat, and Aso F. Salih. "VITAMIN D INTOXICATION IN INFANTS WITH VITAMIN D SUPPLEMENTS." Journal of Sulaimani Medical College 10, no. 1 (March 21, 2020): 67–71. http://dx.doi.org/10.17656/jsmc.10241.
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Lucock, Mark, Patrice Jones, Charlotte Martin, Emma Beckett, Zoe Yates, John Furst, and Martin Veysey. "Vitamin D." Journal of Evidence-Based Complementary & Alternative Medicine 20, no. 4 (April 15, 2015): 310–22. http://dx.doi.org/10.1177/2156587215580491.
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Interest in vitamin D and the VDR gene is increasing as putative roles in human health and evolutionary processes are explored. This review looks beyond the classic biochemistry that links vitamin D to calcium homeostasis; it explores how vitamin D interacts with light in a broader perspective than simple skin photosynthesis. It examines how the vitamin influences circadian rhythm, and how it may have helped drive the evolution of skin pigmentation. To this end, the nutrient–nutrient relationship with folate is also explored. The VDR gene is additionally examined as a factor in the evolutionary selection of skin depigmentation at higher latitudes to allow vitamin D synthesis. Evidence is given to show that VDR polymorphisms exhibit a latitudinal gradient in allele prevalence consistent with such a paradigm. Overall, the review examines new evo-devo ideas that link light-sensitive vitamins to human health/phenotype, both within and across the lifecycle.
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Pusparini, Pusparini. "DEFISIENSI VITAMIN D TERHADAP PENYAKIT (Vitamin D Deficiency and Diseases)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 21, no. 1 (April 15, 2018): 90. http://dx.doi.org/10.24293/ijcpml.v21i1.1265.
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It has been estimated that deficiency and insufficiency of Vitamin D affect one bilion people worldwide. Vitamin D deficiency can befound not only in countries with four (4) seasons, but also in countries with sunlight exposure all year long The objective of this studywas to know whether vitamin D deficiency can occur in Indonesia as well and to explore the role of vitamin D in people‘s health, althoughIndonesia is a country in the equator region. To avoid long term negative health consequences 25 hydroxyvitamin D/25 (OH) D serumlevel should be between 30 and 100 ng/mL. The main source of vitamin D is by synthesis at the skin which is exposed to ultraviolet Bradiation. The other source of vitamin D is from food. There are a lot of causes of vitamin D deficiency, for example: decreased vitaminD synthesis, nutritional intake of vitamin D, maternal vitamin D stores and exclusive breastfeeding, mal absorption and decreasedsynthesis or increased degradation of 25 (OH) D. From the above factors, decreased vitamin D synthesis is the main cause of vitamin Ddeficiency. The vitamin D deficiency is estimated and plays an important role in multiple disorders, such as: osteoporosis, fracture, cancer,cardiovascular disease, diabetes mellitus, autoimmune disease and infectious disease. A good strategy in managing vitamin D deficiencyis needed in order to solve the related problems.
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Gašparini, Dora, and Marija Kaštelan. "Vitamin D i koža." Medicina Fluminensis 57, no. 4 (December 1, 2021): 356–64. http://dx.doi.org/10.21860/medflum2021_264890.
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Povezanost vitamina D i kože započinje sintezom vitamina D u koži, a neprestano se istražuju i uočavaju novi mehanizmi kojima najistraživaniji vitamin utječe na najveći organ ljudskoga tijela. Cilj je ovoga rada dati pregled dosadašnjih spoznaja o interakciji vitamina D i kože te utjecaju razina vitamina D na kožne bolesti. Po nekim istraživanjima suboptimalne razine vitamina D nalaze se u čak 30 – 90 % stanovništva, a procjenjuje se da postoji manjak vitamina D u oko jedne milijarde ljudi na cijelome svijetu. U 25,6 – 68 % pacijenata sa psorijazom postoji nedostatak vitamina D, a manjak vitamina D nazočan je u čak 97 % pacijenata. Nadalje, niz opservacijskih studija i metaanaliza dokazalo je da su serumske razine kalcidiola niže u djece i odraslih s atopijskim dermatitisom, a pojedina istraživanja dokazala su da u čak 70,5 % pacijenata s vitiligom postoji nedostatak vitamina D. Niske razine vitamina D povezuju se i s progresijom malignog melanoma, no nepoznato je u kojem trenutku izloženosti UV zračenju vitamin D prestaje djelovati protektivno i započinje biti rizični čimbenik za razvoj tumora kože. Unatoč brojnim provedenim istraživanjima, još uvijek nije poznata priroda odnosa vitamina D i pojedinih kožnih bolesti, odnosno je li on uzročnoposljedičan ili slučajan, dok se u drugih dermatoza, poput psorijaze, dokazi o povezanosti s razinom vitamina D primjenjuju u svakodnevnom radu s pacijentima – u dijagnostici i liječenju.
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Kroll, Dorothy. "Update on Vitamins: Vitamin D." Alternative and Complementary Therapies 1, no. 3 (April 1995): 172–76. http://dx.doi.org/10.1089/act.1995.1.172.
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BİLGİLİ, Ali, and Onur ALAÇIK. "Levels of Vitamin D in Some Vitamin D Veterinary Preparations Kept in Different Storage Conditions." ISPEC Journal of Agricultural Sciences 6, no. 2 (June 15, 2022): 195–201. http://dx.doi.org/10.46291/ispecjasvol6iss2id287.
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Bu çalışmada, enjektabl preparatlarda vitamin D 3'ün stabilitesi için uygun saklama koşullarının belirlenmesi amaçlanmıştır. Enjekte edilebilir D vitamini preparatlarında vitamin D 3'ün farklı saklama koşulları altında zamana göre değişimleri belirlendi. Mühürsüz (analizin 0. gününde müstahzar mührü açılmış, diğer günlerde analizler için aynı müstahzar kullanılmıştır) ve mühürlü müstahzarlarda (her analiz gününde yeni müstahzar mührü açılarak analiz yapılmıştır) vitamin D analizleri yapılmıştır. 0, 7, 14, 28 ve 56. günlerde güncel ABD Farmakopesinin değiştirilmiş ve doğrulanmış bir yöntemiyle gerçekleştirilmiştir. D3 vitamini değişikliklerinin 4 °C'de saklama koşulları altında 25 °C'ye göre daha yüksek olduğu bulundu. D vitamini oranı 3Mühürsüz müstahzarlardaki değişiklikler, farklı saklama koşulları altındaki mühürlü müstahzarlara kıyasla önemli ölçüde arttı. Sonuç olarak, enjekte edilebilir vitamin preparatları açıldıktan sonra, oda sıcaklığında ve ışıksız çevre koşullarında uygun şekilde saklanabilmektedir.
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Nguyen, Timothy. "Vitamin D and Vitamin D Analogs." Journal for Nurse Practitioners 12, no. 3 (March 2016): 208–9. http://dx.doi.org/10.1016/j.nurpra.2015.12.020.
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S.A. Mursalova, S.S. Safarova, Kh.M. Mirzayeva, S.N. Valiyeva, T.F. Jafarova, and A.N. Khudiyeva. "Qadın reproduktiv sağlamlığı və vitamin D." Actual Questions of Modern Gynecology and Perinatology 10, no. 2 (July 19, 2023): 27–32. http://dx.doi.org/10.28942/mgpam.v10i2.109.
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D vitamini çatışmazlığı 21-ci əsrin pandemiyasıdır. Vitamin D həm qadınlarda, həm də kişilərdə reproduktiv proseslərin tənzimlənməsində mühüm rol oynayır. Vitamin D reseptorları yumurtalıq, endometrium və fallopiya toxumalarında mövcuddur.borularda, həmçinin desidua və plasentada. Vitamin D steroidogenezdə iştirak edir. Məqalədə D vitamini çatışmazlığının bir çox ginekoloji problemlərin, o cümlədən polikistik yumurtalıq sindromu, endometrioz, uşaqlıq leyomyoması, dismenoreya kimi xəstəliklərin inkişafındakı rolundan bəhs edilir.
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Koprivica, Marko, and Svetlana Kašiković-Lečić. "Causes, consequences, and treatment of vitamin D deficiency in humans." Medicinski casopis 57, no. 3 (2023): 119–24. http://dx.doi.org/10.5937/mckg57-43860.
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This group of vitamins consists of vitamin D2 and vitamin D3, which are synthesized in the body of some invertebrates and plants, but also in the human body. Ultraviolet rays cause vitamin D to integrate under the skin. The vitamin is transported via specific proteins to all parts of the body, where it performs numerous roles. The low level of vitamin D in blood is a current public health problem. Vitamin D deficiency is especially pronounced among the elderly and obese. Currently, vitamin D deficiency is associated with an increase in bone and cardiovascular diseases, diabetes, malignant, autoimmune and allergies diseases. That is why it is extremely essential to establish and correct the deficiency of this vitamin in a timely manner. Compensation can be done partly through food, but also through oral supplements, and in more severe cases, by intramuscular administration of vitamins.
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Wilson, Louise R., Laura Tripkovic, Kathryn H. Hart, and Susan A. Lanham-New. "Vitamin D deficiency as a public health issue: using vitamin D2or vitamin D3in future fortification strategies." Proceedings of the Nutrition Society 76, no. 3 (March 28, 2017): 392–99. http://dx.doi.org/10.1017/s0029665117000349.
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The role of vitamin D in supporting the growth and maintenance of the skeleton is robust; with recent research also suggesting a beneficial link between vitamin D and other non-skeletal health outcomes, including immune function, cardiovascular health and cancer. Despite this, vitamin D deficiency remains a global public health issue, with a renewed focus in the UK following the publication of Public Health England's new Dietary Vitamin D Requirements. Natural sources of vitamin D (dietary and UVB exposure) are limited, and thus mechanisms are needed to allow individuals to achieve the new dietary recommendations. Mandatory or voluntary vitamin D food fortification may be one of the mechanisms to increase dietary vitamin D intakes and subsequently improve vitamin D status. However, for the food industry and public to make informed decisions, clarity is needed as to whether vitamins D2and D3are equally effective at raising total 25-hydroxyvitamin D (25(OH)D) concentrations as the evidence thus far is inconsistent. This review summarises the evidence to date behind the comparative efficacy of vitamins D2and D3at raising 25(OH)D concentrations, and the potential role of vitamin D food fortification as a public health policy to support attainment of dietary recommendations in the UK. The comparative efficacy of vitamins D2and D3has been investigated in several intervention trials, with most indicating that vitamin D3is more effective at raising 25(OH)D concentrations. However, flaws in study designs (predominantly under powering) mean there remains a need for a large, robust randomised-controlled trial to provide conclusive evidence, which the future publication of the D2–D3Study should provide (BBSRC DRINC funded: BB/I006192/1). This review also highlights outstanding questions and gaps in the research that need to be addressed to ensure the most efficacious and safe vitamin D food fortification practices are put in place. This further research, alongside cost, availability and ethical considerations (vitamin D3is not suitable for vegans), will be instrumental in supporting government, decision-makers, industry and consumers in making informed choices about potential future vitamin D policy and practice.
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Silva, Guilherme Lobo Oliveira, Jamile Ananda Batista de Vasconcelos, Pedro Luís de Castro Lanzoni Breda, and Larissa Alves Guimarães. "Vitamina D na implantodontia / Vitamin D in implantodontics." Brazilian Journal of Health Review 4, no. 6 (November 25, 2021): 26377–87. http://dx.doi.org/10.34119/bjhrv4n6-219.
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Grey, Vijaylaxmi, Larry Lands, Harpreet Pall, and Donna Drury. "Monitoring of 25‐OH Vitamin D Levels in Children With Cystic Fibrosis." Journal of Pediatric Gastroenterology and Nutrition 30, no. 3 (March 2000): 314–19. http://dx.doi.org/10.1002/j.1536-4801.2000.tb02733.x.
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ABSTRACTBackground:Patients with cystic fibrosis are at risk for malabsorption of fat‐soluble vitamins, and those with low 25‐OH vitamin D levels have a higher risk of low bone mineral density and long‐term skeletal complications. It is currently recommended that vitamins A and E be monitored yearly; however, no recommendations exist for 25‐OH vitamin D. Because all three vitamins are fat‐soluble, the hypothesis in the current study was that low levels of vitamins A and E could identify patients at risk for low 25‐OH vitamin D, so that 25‐OH vitamin D measurements could be obtained in only selected circumstances.Methods:Forty (21 girls) patients with CF, age 10.5 ± 3.9 (SD) years, were assessed in a cross‐sectional survey for ideal weight for height (percentage of predicted), spirometry (percentage of predicted FEV1, 33/40 patients), and serum levels of vitamins A, E, 25‐OH vitamin D, and cholesterol (37/40 patients).Results:Nine (22.5%) of 40 patients were malnourished (percentage of predicted ideal weight for height <85%), 7 (21.2%) of 33 had moderate to severe lung disease (FEV1 <60%), 4 (10%) of 40 had low levels of vitamin A, 3 (7.5%) of 40 had low vitamin E levels, 4 (10.8%) of 37 low vitamin E/cholesterol levels, and 4 (10%) of 40 had marginal or low levels of 25‐OH vitamin D (<40 mmol/l). The patients with low 25‐OH vitamin D were older, with no child < 12 years of age having a 25‐OH vitamin D level less than 40 mmol/l. They also had lower vitamin E and vitamin E/cholesterol levels than those with normal 25‐OH vitamin D levels. The groups did not differ in percentage of predicted ideal weight for height, lung function, or vitamin A levels. The best positive predictor for 25‐OH vitamin D less than 40 mmol/l was low vitamin E (66.7%), with a negative predictive value of 94.6%. 25‐OH vitamin D levels correlated with vitamin E/cholesterol levels (r = 0.41, P < 0.01) and weakly with vitamin E levels (r = 0.28, P < 0.08), but not with vitamin A levels.Conclusions:These results suggest that children aged less than 12 years and older children with normal vitamin E levels are especially unlikely to have low 25‐OH vitamin D levels, and this measure can therefore be omitted. In contrast, those children with low vitamin E levels may warrant monitoring.
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Kotake-Nara, Eiichi, Shiro Komba, and Megumi Hase. "Uptake of Vitamins D2, D3, D4, D5, D6, and D7 Solubilized in Mixed Micelles by Human Intestinal Cells, Caco-2, an Enhancing Effect of Lysophosphatidylcholine on the Cellular Uptake, and Estimation of Vitamins D’ Biological Activities." Nutrients 13, no. 4 (March 29, 2021): 1126. http://dx.doi.org/10.3390/nu13041126.
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Vitamins D have various biological activities, as well as intestinal calcium absorption. There has been recent concern about insufficient vitamin D intake. In addition to vitamins D2 and D3, there are lesser-known vitamins D4–D7. We synthesized vitamins D5–D7, which are not commercially available, and then evaluated and compared the mixed micelles-solubilized vitamins D uptake by Caco-2 cells. Except for vitamin D5, the uptake amounts of vitamins D4–D7 by differentiated Caco-2 cells were similar to those of vitamins D2 and D3. The facilitative diffusion rate in the ezetimibe inhibited pathway was approximately 20% for each vitamin D type, suggesting that they would pass through the pathway at a similar rate. Lysophosphatidylcholine enhanced each vitamin D uptake by approximately 2.5-fold. Lysophosphatidylcholine showed an enhancing effect on vitamin D uptake by reducing the intercellular barrier formation of Caco-2 cells by reducing cellular cholesterol, suggesting that increasing the uptakes of vitamins D and/or co-ingesting them with lysophosphatidylcholine, would improve vitamin D insufficiency. The various biological activities in the activated form of vitamins D4–D7 were estimated by Prediction of Activity Spectra for Substances (PASS) online simulation. These may have some biological activities, supporting the potential as nutritional components.
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Varsamis, Nikolaos, Georgios A. Christou, Christos Derdemezis, Alexandros Tselepis, and Dimitrios Kiortsis. "The Associations of Dietary Vitamin K Intake and Circulating Vitamin 25(OH)D with Serum Lipoprotein Levels: The Vitamin Deficiency Matters." Hormone and Metabolic Research 55, no. 03 (February 27, 2023): 196–204. http://dx.doi.org/10.1055/a-2020-2080.
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AbstractA synergistic interplay between vitamins K and D appears to exist. We aimed to investigate for the first time whether the associations of dietary vitamin K intake and circulating 25(OH)D with serum lipoprotein levels are influenced by the existence of deficiency of either or both vitamins K and D. Sixty individuals [24 males, 36(18–79) years old] were examined. Vitamin deficiency of K1 and D were defined as vitamin K1 intake/body weight (BW)<1.00 μg/kg/day and circulating 25(OH)D<20 ng/ml, respectively. In individuals with vitamin K1 deficiency, the vitamin K1 intake/BW correlated positively with high density lipoprotein-cholesterol (HDL-C) (r=0.509, p=0.008) and negatively with serum triglycerides (TG) (r=–0.638, p=0.001), whereas circulating 25(OH)D correlated negatively with TG (r=–0.609, p=0.001). In individuals with vitamin D deficiency, the vitamin K1 intake/BW correlated positively with HDL-C (r=0.533, p=0.001) and negatively with TG (r=–0.421, p=0.009), while circulating 25(OH)D correlated negatively with TG (r=–0.458, p=0.004). The above-mentioned associations of vitamin K1 intake/BW and circulating 25(OH)D with serum lipoproteins were not detected in individuals without vitamin K1 deficiency or the ones without vitamin D deficiency. The vitamin K2 intake/BW correlated negatively with low density lipoprotein-cholesterol (LDL-C) (r=–0.404, p=0.001). In conclusion, the associations of vitamin K1 intake with TG and HDL-C and of circulating 25(OH)D with TG were more pronounced in individuals with deficiency of either or both vitamins K1 and D. Increased dietary vitamin K2 intake was associated with decreased LDL-C.
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Kaminsky, O. V. "Vitamin D dosage." INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) 17, no. 5 (January 4, 2022): 435–42. http://dx.doi.org/10.22141/2224-0721.17.5.2021.241524.
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Despite its historical name, vitamin D is not a vitamin at all but a hormone that, when activated, is a metabolically active steroid fat-soluble hormone that acts on cellular receptors. Vitamin D hormone is synthesized endogenously and then metabolized in the body, provi-ding that there are the necessary precursors and some factors — the effects of ultraviolet light on the skin. At the same time, vitamins themselves are nutrients, co-factors of biochemical reactions that are not synthesized in the body and cannot interact with receptors, consumed with food, so the hormone D is not a vitamin. Disputes about its use and dosage continue throughout the study period of vitamin D hormone. Most reputable experts in Europe and the USA support the need to replenish and maintain a normal level of vitamin D, believing it to be completely safe and useful. In 2011, the US Endocrine Society issued clinical practice guidelines for vitamin D, indicating that the desired serum concentration of 25(OH)D is > 75 nmol/l (> 30 ng/ml) to achieve the maximum effect of this vitamin on calcium metabolism, bone, and muscle metabolism. According to them, for a consistent increase in serum 25(OH)D above 75 nmol/l (30 ng/ml), adults may require at least 1,500-2,000 IU/day of additional vitamin D, at least 1,000 IU/day in children and adolescents. The most common form of thyroid dysfunction is secondary hyperparathyroidism, which develops due to vitamin D defect/deficiency (80–90 %). Non-optimal serum concentrations of 25(OH)D lead to secondary hyperparathyroidism, potentially leading to decreased bone mineralization and, ultimately, to an increased risk of osteopenia, osteoporosis and fractures, cardiac arrhythmia, and increased blood pressure. Vitamin D is most commonly used at a star-ting dose of 5,000 IU daily for 2–3 months, then transferring patients to maintenance doses of 2,000–4,000 IU/day daily that are consi-dered safe. However, it should be noted that some patients will need constant administration of 5,000 IU of vitamin D per day for a long time (years) to maintain the target optimal level of 25(OH)D in the blood, especially in patients with normocalcemic forms of secondary hyperparathyroidism.
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Okazaki, Ryo. "5. Vitamin D Deficiency and Vitamin D Insufficiency." Nihon Naika Gakkai Zasshi 96, no. 4 (2007): 742–47. http://dx.doi.org/10.2169/naika.96.742.
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Kihal, Abdelhacib, María Ercilda Rodríguez-Prado, Carles Cristofol, and Sergio Calsamiglia. "Short Communication: Quantification of the Effect of Mycotoxin Binders on the Bioavailability of Fat-Soluble Vitamins In Vitro." Animals 11, no. 8 (July 30, 2021): 2251. http://dx.doi.org/10.3390/ani11082251.
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The aim of this study was to determine the capacity of six mycotoxin binders (MTBs) to adsorb vitamins A, D and E in an in vitro system that simulates gastric and intestinal digestion. Experiment 1 evaluated the recovery rate of vitamins A, D and E in the incubation conditions. In Experiment 2, the main factors were the MTB (bentonite, clinoptilolite, sepiolite, montmorillonite, active carbon and yeast cell walls), vitamins (A, D and E) and incubation type (vitamins incubated separately or together). The recovery was high for vitamin D (83%) and E (93%), but low for vitamin A (23%), for which no further analyses were conducted. When incubated separately, vitamin D was only adsorbed by yeast cell wall (20.2%). Vitamin E adsorption was highest with bentonite (54.5%) and montmorillonite (46.3%) and lowest with sepiolite (16.6%) and active carbon (18.5%). When incubated together, vitamin D was not adsorbed by any MTB. Vitamin E adsorption was highest in bentonite (61.8%) and montmorillonite (50.7%) and lowest in sepiolite (15.4%). Results indicate that the bioavailability of vitamin E, but not that of vitamin D, may be reduced in the presence of MTBs.
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Andini, Ary, Farah Nuriannisa, Gilang Nugraha, Nathalya Dwi Kartika Sari, Muslikha Nourma Rhomadhoni, Satya Nugraha Wirayudha, Eka Apriliani Maisurotun Sholeh, Audria Intan Faradita, and Fika Dwi Wahyuningtiyas. "The effect of dietary antioxidant vitamins on malondialdehyde, white blood cells, and platelets." Bali Medical Journal 12, no. 2 (June 16, 2023): 1892–96. http://dx.doi.org/10.15562/bmj.v12i2.4284.
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Introduction: Vitamins have a main role in controlling metabolism in the body and the immune system. Vitamins A, C, and E are known as antioxidant nutrients and vitamin D is essential for innate and adaptive immune function. This study is aimed to analyze the effect of vitamin intake regularly on malondialdehyde (MDA) levels, white blood cell (WBCs) and platelet counts, and differences count of leukocyte Method: The study used 6 groups including the control group without intervention and the intervention group intake of one tablet of vitamin a day for 7 days which were divided into groups of vitamin A 2000 IU, vitamin C 1000 mg, vitamin D 400 IU, vitamin E 100 IU and multivitamins C 1000 mg and D 400 IU Results: Based on the study was explained that vitamins C, D, and E and multivitamins C and D were able to reduce MDA levels and leukocyte counts descriptively but not significantly. The differential leukocyte count has various levels depending on the type of vitamin. Conclusion: Therefore, the consumption of vitamins A, C, D, and E and multivitamins C and D had no significant effect on MDA levels, WBCs count, platelets count, and differential count of leukocyte.
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van Ballegooijen, Adriana J., Stefan Pilz, Andreas Tomaschitz, Martin R. Grübler, and Nicolas Verheyen. "The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review." International Journal of Endocrinology 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/7454376.
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Vitamins D and K are both fat-soluble vitamins and play a central role in calcium metabolism. Vitamin D promotes the production of vitamin K-dependent proteins, which require vitamin K for carboxylation in order to function properly. The purpose of this review is to summarize available evidence of the synergistic interplay between vitamins D and K on bone and cardiovascular health. Animal and human studies suggest that optimal concentrations of both vitamin D and vitamin K are beneficial for bone and cardiovascular health as supported by genetic, molecular, cellular, and human studies. Most clinical trials studied vitamin D and K supplementation with bone health in postmenopausal women. Few intervention trials studied vitamin D and K supplementation with cardiovascular-related outcomes. These limited studies indicate that joint supplementation might be beneficial for cardiovascular health. Current evidence supports the notion that joint supplementation of vitamins D and K might be more effective than the consumption of either alone for bone and cardiovascular health. As more is discovered about the powerful combination of vitamins D and K, it gives a renewed reason to eat a healthy diet including a variety of foods such as vegetables and fermented dairy for bone and cardiovascular health.
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Bhatti, Saeed Akram, Abdul Haseeb Khan, and Shoaib Ahmad. "VITAMIN D STATUS;." Professional Medical Journal 21, no. 05 (December 13, 2018): 918–24. http://dx.doi.org/10.29309/tpmj/2014.21.05.2491.
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… Objective: Our primary objective was to estimate the vitamin D status amongboth the rural and urban dwellers of Sargodha. Study Design: A cross sectional population survey.Place and Duration of Study: Individuals were selected from six different medical centersin the Sargodha city, Vitamin D measurement was done in Khan Lab Sargodha from January2013 to June 2013. Methodology: After an awareness campaign, healthy individuals and medicalpatients from six different clinics in Sargodha city were selected after excluding the diseasesthat interfered with the metabolism of calcium and vitamin D. The initial assessment involvedan interview based questionnaire, at the clinic by the treating doctor. It recorded the informationregarding age, sex, weight, residence, and co-morbid conditions like, DM, hypertension,ischemic heart disease and kidney disease and medications especially oral vitamin D supplementation.The physical assessments included height, weight record and blood pressuremeasurements. The test: It was performed in Khan Lab Sargodha. Quantitative determinationof 25-OH vitamin D was done from the serum by using competitive immunoluminometric assayon Maglumi 1000 fully automated chemistry analyzer. Results: Out of total 100 specimens 46were found to be having low levels of vitamin D levels. Insufficient levels (21-29 ng/ml) were presentin 10 individuals. It was less than 10 ng/ml in 11, less than 5 ng/ml in 4, while 21 individualswere having levels between 10-20 ng/ml. Five individuals had levels more than 100 ng/ml.None of the individuals had level in toxic range. Out of 56 females 27(48.22%) had low vitaminD levels, while out of 44 males 19 (43.2%) were found to be having levels less than 30ng/ml.The median age of individuals having levels less than 30ng/ml was 37 years (14-57 years). Therelationship of high BMI and vitamin deficiency was statistically non-significant (p-value = .282).Conclusions: Although the sample size is small, however our study reveals that a large proportion(46%) of studied individuals representing the asymptomatic general population is havinglow level of vitamin D. in order to address this public issue concrete measures need to be takenin order to prevent adverse consequences of low vitamin D levels.
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Lazić, Vesna, Biljana Mijović, Miloš Maksimović, Olivera Rašević, Maida Mulić, and Maja Vuković. "Vitamin D and atherosclerosis." Биомедицинска истраживања 12, no. 1 (2021): 99–108. http://dx.doi.org/10.5937/bii2101099l.
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Cardiovascular diseases rank first on the mortality list globally or 31%. The basic measure of prevention in accordance with the recommendations of the World Health Organization is a change in risk lifestyle in terms of diet, physical activity, tobacco and alcohol consumption. Vitamin D was previously recognized as a regulator of calcium and phosphorus ratio, bone remodeling or the main controller of skeletal pathophysiology. However, vitamin D enjoys great interest in clinical and epidemiological research in terms of its possible impact on reducing the risk of cardiovascular diseases. Among other things, vitamin D deficiency is associated with an increased risk of endothelial dysfunction. Although the deficiency has been identified as a risk marker for cardiovascular diseases, the mechanism of action of vitamin D on the path from endothelial dysfunction to cardiovascular diseases has not been fully revealed. The findings in this segment of activity of vitamin D would be significant in terms of reducing morbidity and mortality from cardiovascular diseases.
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Jandrić-Kočič, Marijana. "Vitamin D and hypertension." Medicinski glasnik Specijalne bolnice za bolesti štitaste žlezde i bolesti metabolizma 28, no. 89 (2023): 76–91. http://dx.doi.org/10.5937/mgiszm2389076j.
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Vitamin D is the name for a group of fatsoluble secosteroids, prohormones. Almost all tissues of the human body have vitamin D receptors. 3% of the human genome is under the influence of vitamin D. A significant number of epidemiological studies confirmed the integral connection of vitamin D and its metabolites with the value of blood pressure. Vitamin D lowers blood pressure by inhibiting the renin-angiotensin-aldosterone system, modulating the tone of vascular smooth muscle cells and influencing the vascular endothelium. The results of randomized controlled trials and meta-analyses of the same do not generally support the widespread use of vitamin D in the prevention and treatment of arterial hypertension. Nevertheless, a large number of experimental studies confirm the antihypertensive effect of vitamin D supplementation predominantly in people aged ≥ 50 years as well as obese people with vitamin D deficiency. Further research is needed to determine the potential benefit of vitamin D replacement therapy in hypertensive people.
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Látalová, Vendula, František Kopřiva, Denis Dvořák, and Eva Karásková. "Vitamin D and immunity." Česko-slovenská pediatrie 79, no. 2 (April 1, 2024): 77–80. http://dx.doi.org/10.55095/cspediatrie2024/016.
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DUMITRU, Nicoleta, Andra BURUIANĂ, Eugenia PETROVA, Maria OLARU, and Adina GHEMIGIAN. "Vitamin D and maternal-fetal implications." Romanian Journal of Medical Practice 11, no. 2 (June 30, 2016): 151–54. http://dx.doi.org/10.37897/rjmp.2016.2.9.
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Vitamin D is a fat-soluble vitamin and a presteroid hormone synthesized in the dermis under UVB rays. In terms of its endocrine functions, it has an important role in mineral homeostasis. Besides these effects, recent studies have found a series of non-calciotropic actions of vitamin D: modulation of autoimmune processes, promoting secretion and insulin action, pulmonary development, inhibition of malignant cells proliferation in various cancers, implications in maternal-fetal pathology. Recent studies have identified the association of vitamin D deficiency in pregnancy with a series of maternal complications (preeclampsia, bacterial vaginosis, gestational diabetes, increased risk of cesarean delivery) and fetal complications (affecting skeletal development and tooth enamel, impaired fetal growth). Also, newborns from mothers with vitamin D deficiency have an increased risk of tetany, hypocalcemia, with or without seizures and an increased susceptibility to respiratory diseases (asthma, bronchiolitis RSV). Conclusions: There is no current consensus on routine screening of vitamin D deficiency in pregnancy, nor the required dosage for vitamin D supplementation in pregnant women. All pregnant women should have a balanced diet and get vitamin D as part of prenatal vitamins. Their purpose is to increase the availability of calcidiol to the fetus and newborn with a beneficial role over the classic effects of vitamin D and possibly over the non-calciotropic ones.
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Dawson-Hughes, B. "Calcium, vitamin D and vitamin D metabolites." Osteoporosis International 6, S1 (January 1996): 93. http://dx.doi.org/10.1007/bf02499912.
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Butt, Maleeha Tahir, Amber Shami, Waqas Qarshi, Raheela Shaheen, Zarrin Khaliq Chaudari, and Mehak Shafiq. "Vitamin D Deficiency as Etiological Factor for Breast Cancer." Pakistan Journal of Medical and Health Sciences 16, no. 8 (August 30, 2022): 836–38. http://dx.doi.org/10.53350/pjmhs22168836.
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Aim: To determine the association between vitamin D deficiency and breast cancer. Material and methods: This study was conducted on 72 participants, 36 cases and 36 healthy controls were enrolled. Basic demographic information was recorded. Vitamins D deficiency was assessed between both groups. Serum Vitamin D level < 20 ng/ml was considered as vitamin D deficient. Results: Mean age in the cases was 34.64±9.14 years and 36.22±8.78 years in controls. Significant association was found between vitamins D deficiency and breast cancer. In cases there 28 (77.7%) patients with vitamin D deficient and in controls 15 (41.7%) patients. Conclusion: Vitamin D deficiency is a major risk factor for breast cancer.
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Mozos, Ioana, Dana Stoian, and Constantin Tudor Luca. "Crosstalk between Vitamins A, B12, D, K, C, and E Status and Arterial Stiffness." Disease Markers 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/8784971.
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Arterial stiffness is associated with cardiovascular risk, morbidity, and mortality. The present paper reviews the main vitamins related to arterial stiffness and enabling destiffening, their mechanisms of action, providing a brief description of the latest studies in the area, and their implications for primary cardiovascular prevention, clinical practice, and therapy. Despite inconsistent evidence for destiffening induced by vitamin supplementation in several randomized clinical trials, positive results were obtained in specific populations. The main mechanisms are related to antiatherogenic effects, improvement of endothelial function (vitamins A, C, D, and E) and metabolic profile (vitamins A, B12, C, D, and K), inhibition of the renin-angiotensin-aldosterone system (vitamin D), anti-inflammatory (vitamins A, D, E, and K) and antioxidant effects (vitamins A, C, and E), decrease of homocysteine level (vitamin B12), and reversing calcification of arteries (vitamin K). Vitamins A, B12, C, D, E, and K status is important in evaluating cardiovascular risk, and vitamin supplementation may be an effective, individualized, and inexpensive destiffening therapy.
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Mochulska, O. M., O. R. Boyarchuk, M. I. Kinash, O. M. Shulhai, and L. I. Dobrovolska. "Vitamin status as an assessment of vitamins A, E, D providing in children with allergic dermatosis." Modern pediatrics. Ukraine, no. 6(126) (October 29, 2022): 55–61. http://dx.doi.org/10.15574/sp.2022.126.55.
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Vitamins are a group of biologically highly active, low molecular weight organic compounds of various chemical nature, which are practically not synthesized in the body or are synthesized in insufficient quantities, mainly income with food, and are vital to ensure for the flow and regulation of metabolic processes. Vitamins A, E, D play an important role in ensuring the normal functioning of the skin and mucous membranes, adequate immune response, maintaining the body’s resistance to various adverse external factors. Purpose - to study, evaluate and analyze the vitamin status, providing of vitamins A, E, D in children with allergic dermatoses. Materials and methods. 24 children with allergic dermatoses and 32 children of the control group aged 6 to 17 years were examined. General clinical, immunological, biochemical, questionnaires and statistical research methods were used. Results. Among the examined children with isolated allergopathology such as allergodermatoses were diagnosed 10 (41.7%) children, the remaining children were with combined allergic pathology such as allergodermatoses and bronchial asthma 14 (58.3%) children. The research of the providing of vitamins A, E, D in children with allergic dermatoses based on clinical symptoms showed the presence of hypovitaminosis manifestations of vitamin A in 9 (37.5%) children, vitamin E - 8 (33.3%) children, vitamin D - 14 (58.3%) children. Examination of vitamin status in children with allergodermatoses showed a marked decrease in blood levels of vitamin A, a moderate decrease in vitamin D levels, a slight decrease in vitamin E levels compared with children in the control group (p<0.05). In general, all examined children with allergodermatoses and the control group had low levels of vitamin D, subnormal low levels of vitamin A, normal levels of vitamin E according to the recommended criteria of normal supply of vitamins A, E, D according to blood levels. Conclusions. Based on the results of the study, the need for personalized correction of the consumption of vitamins A, E, D, taking into account the composition of the diet in children with allergic dermatoses, who are on elimination hypoallergenic diets were established. The synergistic effect of three vitamins A, E, D at the level of the immune system allows to recommend such a vitamin formula both for prophylactic purposes and in the complex treatment of children with skin allergies. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
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van Ballegooijen, Adriana J., Joline W. J. Beulens, Charlotte A. Keyzer, Gerjan J. Navis, Stefan P. Berger, Martin H. de Borst, Marc G. Vervloet, and Stephan J. L. Bakker. "Joint association of vitamins D and K status with long-term outcomes in stable kidney transplant recipients." Nephrology Dialysis Transplantation 35, no. 4 (February 12, 2019): 706–14. http://dx.doi.org/10.1093/ndt/gfy399.
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Abstract Background Kidney transplant recipients (KTRs) experience substantial survival benefit compared with dialysis patients. However, their mortality and graft failure risk remain high. KTRs are often low in micronutrient status, including vitamins D and K. We investigated the association of both vitamins D and K status, and vitamin D treatment with all-cause mortality and death-censored graft failure. Methods We studied 461 KTRs from a single-centre study at median 6.1 years after transplantation. At baseline, vitamins D and K concentrations were measured by 25-hydroxyvitamin D [25(OH)D] and dephosphorylated uncarboxylated matrix gla protein (dp-ucMGP) and patients were categorized into: 25(OH)D <50/≥50 nmol/L and median dp-ucMGP <1057/≥1057 pmol/L. Results Mean age was 52 ± 12 years, and 122 KTRs (26%) had low vitamins D and K status. During median 9.8 years follow-up, 128 patients (28%) died and 48 (10%) developed death-censored graft failure. Low vitamins D and K status was associated with 2.33 (1.26–4.30) [hazard ratio (95% confidence interval)] increased mortality risk and 3.25 (1.17–9.08) increased graft failure risk compared with KTR with 25(OH)D ≥50 nmol/L and dp-ucMGP <1057 pmol/L. Dp-ucMGP was strongly associated with mortality (per 500 pmol/L increase): 1.41 (1.08–1.41) for vitamin D treatment versus no treatment 1.07 (0.97–1.18), and graft failure 1.71 (1.17–2.49) for vitamin D treatment versus 1.19 (1.05–1.36) no treatment, P-interaction <0.07 for vitamin D treatment (n = 44). Conclusions Combined vitamins D and K deficiency are highly prevalent and are associated with increased mortality and graft failure risk compared with high vitamins D and K status. Low vitamin K status was strongly associated with an increased risk of premature mortality and graft failure for patients treated with vitamin D versus no vitamin D treatment.
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Khan, Nauman, and Tahmina. "Vitamin D Deficiency in the Elderly Patients and Role of Vitamin D in the Prevention of COVID-19 Infection." European Journal of Medical and Health Sciences 3, no. 2 (March 31, 2021): 8–9. http://dx.doi.org/10.24018/ejmed.2021.3.2.765.
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SARS Covid'19 is declared as a global pandemic by World Health Organization [1]. The aim of this short report is to find out the association of Vitamin D in prevention of Covid'19 in elderly patients who are already having other co-morbidities. People of any age are susceptible to Corona virus but the elderly patients and patients with chronic underlying diseases are at higher risk. Many elderly patients with COVID-19 are at risk of mal-nutrition [2].
Vitamins are of two types, Lipid soluble vitamins and water-soluble vitamins [3]. Lipid soluble vitamins can be stored in the body while water soluble vitamins cannot be stored in the body, hence needed to take regularly [4]. Vitamin D is a lipid soluble vitamin also it can be synthesized by our own body.
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Jose, Rosmi, Venketeswaramurthy N, and Sambath Kumar R. "A CRITICAL REVIEW ON HYPOTHESIS, PATHOPHYSIOLOGY OF SCHIZOPHRENIA, AND ROLE OF VITAMINS IN ITS MANAGEMENT." Asian Journal of Pharmaceutical and Clinical Research 11, no. 8 (August 7, 2018): 25. http://dx.doi.org/10.22159/ajpcr.2018.v11i8.23259.
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This review describes about the literatures addressing the role of vitamin supplementation in schizophrenia. Evidence is suggesting that vitamin supplementation includes Vitamin A, Vitamin D, Vitamin E, Vitamin B complex, and Vitamin C may be important in treatment. In schizophrenia, patients may have increased level of homocysteine (Hcy), due to the polymorphism in methylenetetrahydrofolate reductase and hypofunction of N-methyl-D-aspartate receptors. The vitamins main effects are reduced the Hcy level and maintain dopamine and serotonin levels. Add-on treatment with high-dose B vitamins including B6, B9, and B12 and also Vitamin D can significantly reduce symptoms of schizophrenia more than standard treatments alone.
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Elaroussi, M. A., and H. F. DeLuca. "Calcium uptake by chorioallantoic membrane: effects of vitamins D and K." American Journal of Physiology-Endocrinology and Metabolism 267, no. 6 (December 1, 1994): E837—E841. http://dx.doi.org/10.1152/ajpendo.1994.267.6.e837.
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The chorioallantoic membrane (CAM) of birds is an epithelial tissue that actively transports large amounts of Ca during embryonic development. In this study the effect of vitamins D and K on Ca uptake by the CAM was studied. Four dietary treatments were used to produce eggs that are the following: deficient in vitamins D and K (-D/-K), sufficient in both (+D/+K), or deficient in one and sufficient in the other (-D/+K or +D/-K). Vitamin D-deficient (-D) Japanese quail embryos (from hens fed 1,25-dihydroxyvitamin D3) do not hatch because of severe Ca deficiency resulting from their inability to obtain Ca from shell, whereas vitamin K deficiency results in only 14% reduction in hatchability. The results demonstrate that Ca uptake by CAM is vitamin D dependent and only slightly vitamin K dependent. Ca-binding activity of CAM extracts was unchanged by vitamin K deficiency, and only a small increase was provided by vitamin D treatment. Vitamin D stimulated both Ca entry and exist from the chorion cells as indicated by the increased accumulated 45Ca in +D embryos. We conclude that vitamin D is essential for the utilization of eggshell Ca by the developing embryo and hence its survival, suggesting that Ca transport across the CAM is largely a vitamin D-dependent process.
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Zendjabil, Mustapha, and Omar Abbou. "Vitamin D deficiency." Batna Journal of Medical Sciences (BJMS) 2, no. 2 (December 30, 2012): 153–55. http://dx.doi.org/10.48087/bjmsra.2015.2211.
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La vitamine D a des effets sur l’os qui sont bien connus. Ces dernières années, d’autres effets ont été mis en évidence et les études observationnelles ont noté des associations avec de nombreuses pathologies. Le déficit en cette vitamine est très fréquent. L’évaluation du statut en vitamine D repose sur le dosage de la 25-OHD qui a très récemment fait l’objet d’une standardisation. Alors que l’intérêt de la supplémentation en vitamine D dans le cadre des pathologies osseuses est clairement établi, son intérêt dans le cadre des maladies métaboliques et immunitaires n’est pas encore démontré.
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Rosero Olarte, Oscar. "Vitamina D y salud ósea en la mujer posmenopáusica. Revisión." Revista Colombiana de Endocrinología, Diabetes & Metabolismo 2, no. 1 (March 25, 2017): 14–19. http://dx.doi.org/10.53853/encr.2.1.66.
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La vitamina D es un determinante importante de la salud ósea y de la función neuromuscular. Recientemente se ha catalogado el déficit de vitamina D como un problema epidémico de proporción mundial.Evidencia reciente sugiere que el aporte de vitamina D en dosis suficiente disminuye el riesgo de fracturas, así como el riesgo de presentar caídas en pacientes ancianos.Mantener un nivel adecuado de vitamina D es una práctica simple y poco costosa que contribuye a disminuir las consecuencias que su déficit representa para la salud ósea.
Abstract Vitamin D is an important determinant of bone health and neuromuscular function. Vitamin D deficiency is now recognized as a worldwide epidemic. Recent evidence suggests that vitamin D intake in a sufficient dose decreases the risk of fractures and falls among elderly patients. It takes a simple and low-cost practice to maintain vitamin D at suitable levels, thus contributing to decrease the consequences that its deficit entails for bone health.
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Shamaoon, Muhammad, Dr Maryam, Muhammad Ahsan, and Rahman Ahmad. "VITAMIN D AND PNEUMONIA." Professional Medical Journal 25, no. 04 (April 10, 2018): 532–37. http://dx.doi.org/10.29309/tpmj/2018.25.04.341.
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Background: Pneumonia is lower respiratory tract infection (LRTI) andrepresents inflammatory conditions of the lungs i.e of the lower respiratory tracts, air sacs andlung parenchyma.1 Objectives: To determine the role of vitamin D supplementation in reducingmorbidity in children with pneumonia. Study Design: Randomized Controlled trial. Place andDuration of Study: Pediatric Department, Mayo Hospital Lahore from December 2014 to May2015. Patient & Methods: Two hundred children of age 2 – 59 months with pneumonia (fever,cough, tachypnea, and subcostal recessions) and low vitamin D level (< 20 ng/ml) were includedin the study. One Hundred pneumonia patients received antibiotics (group A) and vitamins D(100,000 IU) while another group of hundred patients received only antibiotics without vitaminsupplementation (group B). When respiratory distress settled, length of stay in hospital wascalculated at the time of discharged. All patients were followed in pediatric OPDs for 3 monthsafter in-hospital treatment to pick recurrence of pneumonia symptoms (if any). Results: Themean recovery time for vitamin D group (5.7 +2.8 days) and non-vitamin D (6.1+2.8 days)was almost same with P=0.29. But the frequency of repeated episodes of pneumonia within30 days of treatment was lower in intervention group n=4 (2%) than the non-intervention groupn=18 (9%) (P = 0.002). Conclusion: 100,000 IU of vitamin D given once during treatment ofpneumonia decreases the chances of recurrence in the next 30 days.
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Melo van Lent, Debora, Sarah Egert, Steffen Wolfsgruber, Luca Kleineidam, Leonie Weinhold, Holger Wagner-Thelen, Birgit Stoffel-Wagner, et al. "Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old." Nutrients 15, no. 1 (December 23, 2022): 61. http://dx.doi.org/10.3390/nu15010061.
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Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities. Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom n = 250 developed all-cause dementia and n = 209 developed Alzheimer’s dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia. Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively). In particular, subjects with vitamin D deficiency (25.3%, <25 nmol/L) were at increased risk for all-cause dementia and AD (HR1.91 (95%CI 1.30; 2.81); HR2.28 (95%CI 1.47; 3.53), respectively). Vitamins A and E and beta-carotene were unrelated to (AD) dementia. Conclusions. Vitamin D deficiency increased the risk to develop (AD) dementia. Our study supports the advice for monitoring vitamin D status in the elderly and vitamin D supplementation in those with vitamin D deficiency. We observed no relationships between the other vitamins with incident (AD) dementia, which is in line with previous observational studies.
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Santos, Lorena Vieira, and Marcos Alan Vieira Bittencourt. "VITAMINA D E SUA INFLUÊNCIA NA ORTODONTIA INFLUENCE OF VITAMIN D IN ORTHODONTICS." Revista da Faculdade de Odontologia da Universidade Federal da Bahia 47, no. 2 (March 4, 2020): 39–44. http://dx.doi.org/10.9771/revfo.v47i2.35773.
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A vitamina D é um hormônio que encontra receptores em vários órgãose tecidos, regulando os níveis de cálcio e fosfato no organismo.Níveis adequados de vitamina D são imprescindíveis para a saúde dosossos e dos dentes em crianças e adultos mas, atualmente, a hipovitaminoseD tem sido verificada com elevada prevalência. A escassezresulta em anormalidades na mineralização óssea, pela redução dafunção dos osteoblastos e pela alteração na formação e recrutamentodos osteoclastos. Esta interferência no remodelamento ósseo temestimulado a busca pela compreensão da influência e participaçãoda vitamina D na movimentação dentária ortodonticamente induzida.Sugere-se que sua aplicação local promove aumento na taxa derecrutamento e ativação dos osteoclastos, resultando em maior reabsorçãoóssea alveolar no lado de pressão do ligamento periodontal, eaumento no número de osteoblastos na superfície oposta do alvéolo,indicando uma formação óssea mais intensa. Além disto, estudos têmconcluído que a vitamina D não parece estar entre as variáveis potenciaispara reabsorção radicular. Por outro lado, pesquisas também têmsido conduzidas com o objetivo de avaliar sua influência no desenvolvimentodentário e do complexo craniofacial, uma vez que cálcioe fosfato são fundamentais para estes processos. Contudo, embora aprodução de pesquisas tenha aumentado consideravelmente, aindahá poucos trabalhos no campo da Ortodontia que esclareçam a realimplicação da deficiência ou excesso de vitamina D nas respostas teciduaisrelacionadas ao movimento dentário. ABSTRACTVitamin D is an hormone with receptors in a great variety of organs andtissues, acting to regulate calcium and phosphate levels in the body.Adequate levels of vitamin D are very important for the health of boneand teeth in both children and adults. However, nowadays, vitaminD deficiency has been verified with high prevalence. This deficiencyresults in abnormalities in bone mineralization, because of the reductionof osteoblasts function and disturbance in osteoclasts formationand recruitment. This influence in bone remodeling has stimulatedthe search for better understanding the influence and participation ofvitamin D in orthodontically induced dental movement. It has beensuggested that its local application promotes an increase in the rate ofrecruitment and activation of osteoclasts on the pressure side of theperiodontal ligament, which results in increased alveolar bone resorption,and an increase at the number of osteoblasts on the opposite surfaceof the alveolar bone, which indicates a greater bone formation.In addition, studies have shown that vitamin D does not appear to beamong the potential variables for root resorption. On the other hand,researches have also been conducted with the aim of evaluating itsinfluence on dental and facial development, since calcium and phosphateare essential for these processes. However, although the number of published researches has increased considerably, thereare still few studies involving orthodontics that clarify the realimplication of vitamin D deficiency or excess in tissue responsesrelated to tooth movement.
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Ibrahim Abdullah, Muhammadu, Bashir Abdulkadir, Hafsatu Garba Bawa-Sani, Mujahid Hussaini, O. R. Ibrahim, F. M. Umar, and Habibat Bello Bolanle. "Impact of Vitamin D Supplementation in the Therapy Of Tuberculosis." UMYU Journal of Microbiology Research (UJMR) 8, no. 2 (December 30, 2023): 24–29. http://dx.doi.org/10.47430/ujmr.2382.004.
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Ultraviolet B (UV-B) synthesis occurs when the skin is exposed to sunshine and produces vitamin D as a result. Additionally, nutritional supplements and diet can provide it. Animals are the primary source of vitamin D. Vitamin D has been identified as a risk factor for tuberculosis (TB) disease and infection. It is considered that vitamin D influences the release of antimicrobial peptides like cathelicidin in response to viral and bacterial stimuli, which is thought to affect both the innate and adaptive immune systems. This essay sought to provide an outline of vitamin D's role in the treatment of tuberculosis. For journal articles, reports, and reliable sources, several databases were searched to compile pertinent information. Additionally, search terms were utilised interchangeably to find pertinent materials. The majority of the literature revealed a connection between vitamin D levels and TB. Furthermore, research has indicated that certain vitamins, including Vitamins C and D, have antimycobacterial capabilities. Despite contradicting data about the relationship between Vitamin D Deficiency (VDD) and the risk of tuberculosis, vitamin D supplementation is still a viable strategy. The analysis of the impact of vitamin D supplementation as a potential therapeutic intervention for TB infection should pay more attention to exploring larger sample sizes and metabolite chemicals.
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Beaulieu, Normand, Norman M. Curran, Charles Gagné, Micheline Gravelle, and Edward G. Lovering. "Liquid Chromatographic Methods for Vitamins A and D in Multivitamin-Mineral Formulations." Journal of AOAC INTERNATIONAL 72, no. 2 (March 1, 1989): 247–54. http://dx.doi.org/10.1093/jaoac/72.2.247.
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Abstract Liquid chromatographic screening procedures have been developed for the estimation of vitamins A and D in multivitamin-mineral tablet, capsule, gelatin capsule, and syrup formulations. The procedure can be used for measuring vitamin A present as either retinyl acetate or retinyl palmitate, and also for measuring the contribution to total vitamin A activity from 13-cis retinyl esters. The retinyl esters and their isomers are resolved from each other and their oxidation products. Ergocalciferol and cholecalciferol are not resolved from each other but they are resolved from other vitamin D isomers and from vitamins A, E, and K and their degradation products. Both assays use a 3 μm amino column, with a mobile phase of hexane for vitamin A and 1% isopropanol in hexane for vitamin D. The precision of replicate injections for vitamins A and D is better than 1% and the recovery from spiked syrups is better than 98%. The coefficient of variation for both assay methods is about 5%. Twenty formulations were analyzed for vitamin A and 24 were analyzed for vitamin D.
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Shikh, Evgenia V., Anna A. Makhova, and Ekaterina I. Alekseeva. "Vitamins А, С and D — Essential Trio for Infants." Current Pediatrics 18, no. 3 (September 18, 2019): 152–59. http://dx.doi.org/10.15690/vsp.v18i3.2031.
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Administration of essential vitamins A, C and D in vitamin-mineral complex in common dosage is efficient for immunity formation, harmonious physical and neuropsychic development, rickets prevention. Dosage of components at the physiological daily maintenance in basic vitamin complexes for infants is integral for nursing mother supplementation and fortification of the food used for infant weaning. If necessary, and specifically in immature infants, the basic vitamin complex (vitamins A, C and D) can be extended with other required micronutrients (vitamin D, for example, can be extended up to 1000 ME). It depends on feeding type, intake of vitamin-mineral complexes for nursing mothers, seasonal prevalence, region and many other factors.
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Andrade, Isabella Pedrotti Leme de, Taís Donha Yarid Angelieri, Vitória de Oliveira Cristóvão, Luiza Santucci Teixeira, Giovanna Rossetto Magalhães, Carolina Vieira Marum, and João Kleber de Almeida Gentile. "Hypovitaminosis D in post bariatric patients: Narrative review." Brazilian Journal of Case Reports 3, no. 3 (February 20, 2023): 3–7. http://dx.doi.org/10.52600/2763-583x.bjcr.2023.3.3.3-7.
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Obesity can be associated with several diseases, signs, and symptoms. Among them, there is nutrient deficiency, especially vitamin D, which regulates calcium and phosphate and helps in bone remodeling. Vitamin D deficiency is related directly to the inadequate intake of foods rich in vitamins, less exposure to the sun and, mainly, to the sequestration of fat-soluble vitamins by the adipose tissue, making it even more difficult for the body to absorb them. Among these complications is the worsening of vitamin deficiency, with a focus on vitamin D, which is already present before the patient undergoes bariatric surgery. Regarding the types of bariatric surgery, each one establishes a degree of vitamin D deficiency that the patient will have postoperatively. That is, each type of bariatric surgery, as they are performed in different ways, directly interfere with the patient's absorption of vitamins. Postoperatively, vitamin D supplementation is recommended for all patients. However, due to poor patient compliance and lack of consent among physicians on the best form of supplementation, the deficiency is maintained, further impairing the treatment, and causing a worsening of the bariatric patient's condition.
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Rosales, Cristian J., and Debasish Bandyopadhyay. "Vitamin D: Controversy Cancer and Beyond." Journal of Nutritional Biology 4, no. 2 (October 17, 2018): 236–43. http://dx.doi.org/10.18314/jnb.v4i2.1374.
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Vitamins are an essential part to wellbeing. This was not something always known however, as the Germ theory was the accepted thesis of the 18th century. It was found that certain accessory factors helped mitigate and even cure these diseases such as beriberi, scurvy, and rickets. Accessory factors, later coined vitamins by Casimir Funk, are an essential constituent of the human diet. Vitamin D is technically not a vitamin but functions as a steroid hormone whose most well-known purpose is calcification of the human skeleton. This helps prevent osteomalacia in adults and rickets, a serious problem in children due to their developmental stages. But besides its well-known role, vitamin D also has other important non-calcification purposes, including being a possible anticancer agent. Calcitriol (1,25 dihydroxycholecalciferol, vitamin D3) has found to treat certain cancers in various ways: from the VDR-RXR complex to analogs being able to decrease tumor growth, lowering expression of stem cell marker genes, and inhibition of the Wnt pathway. Although there is promise in its effectiveness based on studies of squamous cell carcinoma, prostate, breast, colon, and ovarian cancer; hypercalcemia, lack of consistent data, and insufficient clinical trials are serious issues that constantly get in the way of progression of vitamin D’s legitimacy as a solution.
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Remy, Daniella, Gillian Murphy, Michelle Mravunac, Daen Medina, Tina Taylor, Cecile Konn, Colombe Holloway, and Ran Zheng. "Vitamins for the Prevention and/or Treatment of COVID-19: An Umbrella Review." CAND Journal 30, no. 4 (December 28, 2023): 15–31. http://dx.doi.org/10.54434/candj.160.
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Objective: This umbrella review synthesizes the existing literature on the role of vitamins for COVID-19 prevention and management. The objective is to elucidate potential preventive and therapeutic dimensions of these vitamins, highlight clinical applicability, and identify avenues for future research. Methods: A systematic search was conducted using PubMed and Google Scholar, with predefined key words for each vitamin combined with COVID-19-related terms. Narrative and systematic reviews were included, following Cochrane guidelines. AMSTAR scoring was used to assess systematic review quality, while SANRA guidelines were used to evaluate narrative reviews. Data extraction, synthesis, and reference overlap were conducted. Findings: Narrative reviews (n=14) revealed preclinical benefits of vitamins A, B group, C, D, and E (no research on vitamin K found) in COVID-19 management, with potential for immune modulation and anti-inflammatory responses. Of the systematic reviews (n=44), none included vitamins A or E. Some B vitamins exhibited potential, with significant associations between vitamin C supplementation and reduced COVID-19 severity. Many significant findings were also found between vitamin D deficiency and heightened COVID-19 risks, as well as promising effects of vitamin D supplementation. Conclusion: Vitamins A, B group, C, D, and E hold mechanistic rationale for combating COVID-19, as suggested by narrative reviews. In systematic reviews, vitamin D deficiency underscores its role in COVID-19 severity, while vitamin C and D supplementation show potential benefits as adjunct therapies. This umbrella review highlights the comprehensive research on the efficacy of vitamins in addressing COVID-19, with challenges that warrant further investigation.
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