Journal articles on the topic 'Vitamin B complex Physiological effect'
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Dawood, Tamara N. "Effect of vitamin C and/or vitamin B complex intake on some productive, physiological and reproductive traits in the female rabbits." Iraqi Journal of Veterinary Medicine 39, no. 1 (June 4, 2015): 8–15. http://dx.doi.org/10.30539/iraqijvm.v39i1.188.
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The aim of this work was to establish the vital role of using vitamin B complex and/or vitamin C in the reproduction. Twenty female rabbits were used and they were divided randomly into four equal groups, all animals were fed 100 g of concentrate pellets diet/ head. The first group was offered drinking water free of vitamins, (control group), second group was supplied with water containing vitamin C (40 mg/ 100ml water/ head), third group was supplied with water containing vitamin B complex (0.5 ml/100ml/head), and fourth group was water supplied containing 20 mg of vitamin C and 0.25 ml of vitamin B complex/100 ml water/head. At the beginning of the experiment, male rabbits were introduced to the females for mating for one hour at morning daily for two weeks before the food and water were supplied. The results revealed that, body weight of all groups increased progressively with age. The treated groups gained insignificantly more than the control group, the second and fourth group showed higher but insignificant. In second and third group caused significant increase in PCV, Hb, WBCs, lymphocyte percentage and decrease in neutrophil, monocyte and eosinophil percentages compared with the control group. However, blood glucose and serum cholesterol levels were significantly decreased (P<0.05) in second and fourth group when compared with first group. While vitamins groups caused insignificant increase in alkaline phosphatase activity enzyme. However, the treated groups showed significantly higher fertility rate and reproductive efficiency ratio compared with the control group and numerically higher in prolificacy ratio (%). But third and fourth group showed better prolificacy and reproductive efficiency ratio than the second group
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Hrubša, Marcel, Tomáš Siatka, Iveta Nejmanová, Marie Vopršalová, Lenka Kujovská Krčmová, Kateřina Matoušová, Lenka Javorská, et al. "Biological Properties of Vitamins of the B-Complex, Part 1: Vitamins B1, B2, B3, and B5." Nutrients 14, no. 3 (January 22, 2022): 484. http://dx.doi.org/10.3390/nu14030484.
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This review summarizes the current knowledge on essential vitamins B1, B2, B3, and B5. These B-complex vitamins must be taken from diet, with the exception of vitamin B3, that can also be synthetized from amino acid tryptophan. All of these vitamins are water soluble, which determines their main properties, namely: they are partly lost when food is washed or boiled since they migrate to the water; the requirement of membrane transporters for their permeation into the cells; and their safety since any excess is rapidly eliminated via the kidney. The therapeutic use of B-complex vitamins is mostly limited to hypovitaminoses or similar conditions, but, as they are generally very safe, they have also been examined in other pathological conditions. Nicotinic acid, a form of vitamin B3, is the only exception because it is a known hypolipidemic agent in gram doses. The article also sums up: (i) the current methods for detection of the vitamins of the B-complex in biological fluids; (ii) the food and other sources of these vitamins including the effect of common processing and storage methods on their content; and (iii) their physiological function.
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Pyatnychko, O. M., M. I. Zhyla, N. V. Shkodyak, O. O. Saliy, M. V. Derkach, and L. V. Kalynovska. "The efficiency of the drug based on butaphosphane, B vitamins and L-carnitine in the treatment of horses." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 23, no. 101 (April 5, 2021): 31–37. http://dx.doi.org/10.32718/nvlvet10106.
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An important feature of living organisms, acquired in the process of evolution, is the ability to adapt to various external influences and changes in the environment, to maintain homeostasis and regulatory processes in organs, systems and the body as a whole. However, with modern breeding technologies, the physiological capabilities of the animal's body are often unable to change as quickly as required by the conditions of industrial maintenance, which leads to stress. Vitamin preparations and biologically active feed additives are widely used by veterinary medicine specialists to increase resistance to stressful situations, disease prevention, increase resistance, safety and productivity of farm animals. Preparation L-tsyn, solution for injection (manufactured by BIOTESTLAB LLC), is a drug, the action of which is due to the prescription combination of active substances, namely: butaphosphane, B vitamins (vitamin B12, vitamin B3) and L-carnitine. The aim of the study was to investigate the effectiveness of the drug L-tsyn on horses under the influence of stressors of various natures. Two experiments on working horses with constant, excessive physical activity with chronic exercises and with complex therapy of intoxication with signs of acute renal failure in horse were conducted. Clinical trials of the drug were performed on working horses aged 5–15 years, of different sexes. The drug was administered in a dose of 20–25 ml per animal, 1 time per day for 5 consecutive days. The clinical condition of the experimental animals was observed for 21 days from the start of the drug. The morpho-functional state of the animal's body before and after the drug was established according to the indicators of the clinical condition, morphological and biochemical parameters of the blood, which were determined according to generally accepted methods. In working horses under excessive load the drug L-tsyn activated the processes of hematopoiesis, improved the physiological state of the body and contributed to the increase the general tone of the body. The drug as part of complex therapy in the treatment of intoxication, showed hepato- and nephroprotective properties, reduced the manifestations of intoxication, helped to restoration of the animal’s normal physiological state. According to the results of clinical, hematological and biochemical studies, it can be concluded that the drug L-tsyn has a stimulating effect on metabolic processes in the animals’ body, shows tonic properties, increases the body's resistance to toxins and adverse environmental factors and can be used as monotherapy and for the complex treatment of diseases of various etiologies in horses.
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Rahmawati, Alfiah, Rr Catur Leny Wulandari, Atika Zahria Arisanti, and Alivia Nurrokhmah. "THE EFFECT OF DATE JUICE AND HONEY ON INCREASING HEMOGLOBIN IN PREGNANT WOMEN WITH ANEMIA." International Journal of Islamic and Complementary Medicine 3, no. 2 (September 23, 2022): 57–64. http://dx.doi.org/10.55116/ijicm.v3i2.43.
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Pregnancy is a physiological change in women. There are changes in the body during pregnancy, one of which is in the blood vessel system. These changes make the volume of plasma in the blood increase, this results in dilution of the blood. From these changes, pregnant women are prone to anemia, where the condition of the body lacks blood. Globally, the incidence of anemia reaches 29.9% in women of childbearing age or more than half a billion women aged 15-49 years have anemia. With a prevalence of 29.6% in non-pregnant women of childbearing age and 36.5% in pregnant women of childbearing age. Anemia in pregnancy has several effects such as premature birth and postpartum hemorrhage. So anemia during pregnancy requires serious treatment. There are pharmacological and non-pharmacological treatments for anemia. One of the non-pharmacological treatments that can be done is using dates and honey. Dates and honey contain iron, vitamin C, vitamin B complex and folic acid which are needed in the formation of blood cells. In this case, the researcher conducted a search for evidence of foreign literature traced through electronic media facilities with keyword guidance. There were 6 relevant articles, each of which represented an effect of giving dates and honey in cases of anemia during pregnancy, especially in pregnant women who have anemia.
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Golovach, P. I., M. M. Zmiya, and S. O. Pokotylo. "Morphological composition of blood and clinical indicators in ball fattening on the effect of b vitamins (В1, В2, В5, В6, В10, В12)." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 22, no. 99 (October 28, 2020): 53–57. http://dx.doi.org/10.32718/nvlvet9908.
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In realization of the genetic productivity potential of different species of farm animals, an important place is given to full feeding. Insufficient supply of farm animals with individual vitamins has negative impact on the activity of the relevant enzyme systems, hormonal status, metabolism of nutrients, the state of the natural resistance of the various organs and organ systems, the processes of adaptation and productivity level. Numerical searches have shown that farm animals need in different vitamins depends on the type, age, sex, physiological state, the season, the level of productivity and others. According to some reports ruminants have been providing with water-soluble B vitamins by their rumen microbial synthesis accordingly it was recommended to rations setting for cattle, sheep and goats, along with nutrients and minerals only by carotene and vitamins D and E. Specific features of the effect of different doses of complex B vitamins (thiamine hydrochloride, riboflavin, niacin, pyridoxine hydrochloride, folic acid, ciankobalamin in venous blood) on morphological composition (erythrocytes, leukocytes, platelets, hemoglobin, hematocrit, erythrocyte sedimentation rate) and clinical indicators (heart rate, respiratory rate, type temperature) at the final stage bull fattening. Studies have shown that the addition to the diet of calves for fattening balanced nutrients and minerals and fat-soluble vitamins A, D, E complex of B vitamins (В1, В2, В5, В6, В10, В12) in appropriate doses generally positive effect on erythrocytes, leukocytes, hemoglobin, hematocrit, dose-dependent additionally introduced into the diet of B vitamins (В1, В2, В5, В6, В10, В12). The basis for our dosage of various B vitamins for Bovine experimental groups on fattening is the corresponding percentage of the recommended doses of certain B vitamins for fattening pigs (10 % – D1, 20 % – D2, 40 % – D3, 60 % – D4 group). The biggest change in terms on morphological composition in animals 3rd ((В1 – 0,040; В2 – 0,06; В5 – 1.2; В6 – 0.25; В10 – 0.0030; В12 – 0.0006 mg/kg body weight) and 4th (В1 – 0.070; В2 – 0.10; В5 – 2.0; В6 – 0.40; В10 – 0.0050; В12 – 0.0010 mg/kg body weight) research groups, and smallest – in bull 1st (В1 – 0.015; В2 – 0.03; В5 – 0.5; В6 – 0.10; В10 – 0.0012; В12 – 0.0002 mg/kg body weight) and 2 th (В1 – 0.025; В2 – 0.04; В5 – 0.8; В6 – 0.15; В10 – 0.0020; В12 – 0.0004 mg/kg body weight) research group, which is associated with dose introduced to the diet of calves during the final fattening phase of B vitamins (В1, В2, В5, В6, В10, В12).
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Fathimah, Fathimah, Vina Intan Aprilia, Kartika Pibriyanti, Lulu' Luthfiya, and Hafidhotun Nabawiyah. "THE EFFECT OF DATE FRUITS (PHOENIX DACTYLIFERA L) INTERVENTION TO INCREASE HEMOGLOBIN LEVELS IN FEMALE ADOLESCENTS." Media Gizi Mikro Indonesia 13, no. 2 (July 22, 2022): 97–104. http://dx.doi.org/10.22435/mgmi.v13i2.5138.
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Background. Anemia is one of the common health problems globally, where a condition of red blood cells is inadequate to meet the physiological needs caused by iron deficiency. The short term impact of anemia on adolescents can cause growth disorders, while the long term impact on pregnant women can cause pregnancy and childbirth complications. Date fruit is one of the fruits that containing iron (Fe), vitamin C, vitamin B complex, and folic acid that can help form red blood cells. Consuming the date fruits may improve formation of red blood cells and prevent anemia. Objective. To determine the effect of the intervention of date fruits in increasing hemoglobin levels among female adolescents at Islamic boarding school. Method. This research was performed using a pre-experimental study with one group pretest and posttest design. The sampling method in this research used purposive sampling with samples of 30 female adolescent students aged 15–18 years old at Modern Islamic Boarding School (Pondok Modern Gontor Putri 2), Ngawi, East Java, Indonesia. The inclusion criteria was adolescent suffering from anemia (age 15 until 18 years, Hb <12 g/dL, not menstruation during intervention). The intervention was carried out for seven days by giving seven date fruits (50 g) per day. Hemoglobin levels had recorded before and after intervention. The data were analyzed using paired t-test. Results. The median hemoglobin (Hb) level before giving date fruits was 10.8 g/dL and the median Hb level after giving date fruits was 11.9 g/dL. There were differences in Hb levels before and after giving date fruit in the treatment group (p=0.001). Conclusion. The intervention of consuming seven date fruits (50 g) for seven days effectively increased hemoglobin level.
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Zmiya, M. M., and P. I. Golovach. "СТАН ГУМОРАЛЬНОЇ ЛАНКИ ІМУННОГО СТАТУСУ У БУГАЙЦІВ НА ВІДГОДІВЛІ ЗА ВПЛИВУ ВІТАМІНІВ ГРУПИ B (B1, B2, B5, B6, B10, B12)." Scientific Messenger of LNU of Veterinary Medicine and Biotechnology 18, no. 3(70) (September 5, 2016): 115–19. http://dx.doi.org/10.15421/nvlvet7027.
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In realization of the genetic productivity potential of different species of farm animals, an important place is given to full feeding. Insufficient supply of farm animals with individual vitamins has negative impact on the activity of the relevant enzyme systems, hormonal status, metabolism of nutrients, the state of the natural resistance of the various organs and organ systems, the processes of adaptation and productivity level.Numerical searches have shown that farm animals need in different vitamins depends on the type, age, sex, physiological state, the season, the level of productivity and others. According to some reports ruminants have been providing with water–soluble B vitamins by their rumen microbial synthesis accordingly it was recommended to rations setting for cattle, sheep and goats, along with nutrients and minerals only by carotene and vitamins D and E .Studies have shown that the addition to the diet of calves for fattening complex of B vitamins (В1, В2, В5, В6, В10, В12) in different doses generally positive effect on bactericidal, lisocim and complement activity of blood serum, immunoglobulin cell in bull fattening.Studies have shown that the addition to the diet of bull fattening balanced in nutrients and minerals and fat–soluble vitamins A, D, E complex of B vitamins (В1, В2, В5, В6, В10, В12) in appropriate doses generally positive effect on humoral immunity state, major changes are complement activity of blood serum, depends on the dose additionally entered the diet fattening bulls B vitamins.The biggest change on humoral immunity state of calves for fattening derived from animals 3rd D (B1 – 0.040; B2 – 0.06; B5 – 1.2; B6 – 0.25, B10 – 0.0030; B12 – 0.0006 mg/kg body weight) and 4th D (B1 – 0.070; B2 – 0.10; B5 – 2.0; B6 – 0.40; B10 – 0.0050; B12 – 0.0010 mg/kg body weight) groups, and the smallest – in calves 1th D (В1 –0.015; В2 – 0,03; В5 – 0.5; В6 – 0.10; В10 – 0.0012; В12 – 0.0002 mg/kg body weight) group.
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Danylenko, Svitlana, Lolita Marynchenko, Viktoriia Bortnyk, Oksana Potemska, and Olena Nizhelska. "Use of Highly Dispersed Silica in Biotechnology of Complex Probiotic Product Based on Bifidobacteria." Innovative Biosystems and Bioengineering 6, no. 1 (May 6, 2022): 16–24. http://dx.doi.org/10.20535/ibb.2022.6.1.256179.
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Background. The probiotics immobilization technology is one of the most effective ways for controlled and continuous delivery of viable cells into the intestine. It is well known that multifaceted physiological roles of bifidobacteria are to normalize and stabilize the microbiocenosis, to form intestine colonization resistance, to synthesis amino acids, proteins and vitamins, to maintain non-specific resistance of the organism and so all. Such a wide range of positive effects on the macroorganism allows us to consider bifidobacteria as a basis for functional immobilized healthcare products development.
Objective. Taxonomic position determination of the Bifidobacterium longum strain selected for immobilization, study of the viability of this bifidobacteria strain in a complex probionic product based on highly dispersed silica in simulated gastrointestinal tract's conditions and after freeze-drying.
Methods. The production strain Bifidobacterium longum IMV B-7165 from the Institute of Food Resources of the National Academy of Agrarian Sciences of Ukraine collection of industrial strains has been used in the study. It was isolated from the healthy human infant's gastrointestinal tract.
Commonly used bioinformatics, microbiological, biotechnological and statistical methods have been applied.
Results. The best alignments for the sequence of bifidobacteria isolate "4202" 16S rRNA (it was previously deposited as Bifidobacterium longum IMV B-7165) and classic dendrograms based on these results were performed. According to the results of microscopic studies of samples of microorganisms with highly dispersed silica products ("Enterosgel", "Sillard P" and "Toxin.Net") it was found that the immobilization of the Streptococcus thermophilus and bifidobacteria cultures did not differ fundamentally. To study the immobilization effect on the bifidobacteria preservation and properties the following carriers were used: "Enterosgel", "Toxin.NET" and "Sillard P". The survival of immobilized bifidobacteria was further studied in simulated gastrointestinal conditions: immobilized cells are better protected from acid and bile, although with increasing acidity, survival decreases in both control and immobilized cells.
Conclusions. The taxonomic position of a bifidobacterial isolate from the healthy human infants used in immobilization studies was clarificated (Bifidobacterium animalis subsp lactis). Under the simulated conditions of the upper gastrointestinal tract in the case of acid and bile impact, the best survival was demonstrated by immobilized cultures of bifidobacteria together with the Enterosgel sorbent (a content of 10% by weight of the culture). The survival of immobilized preparations after freeze-drying was slightly reduced in the case of immobilization on the "Enterosgel" and "Toxin.NET" samples of enterosorbents (a content from 15% to 25% by weight of the culture). The best results were observed in the case of immobilization of bifidobacteria with 5% content of the "Toxin.NET" enterosorbent (enterosgel + inulin).
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Farkhutdinova, A. R., and M. T. Sabitov. "Feed additive based on biologically active substances for fattening steers." Kormlenie sel'skohozjajstvennyh zhivotnyh i kormoproizvodstvo (Feeding of agricultural animals and feed production), no. 7 (July 1, 2021): 58–65. http://dx.doi.org/10.33920/sel-05-2107-06.
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The modern agricultural market offers a wide range of products designed for a highly effective and most importantly safe increase in growth indicators, the level of development and the degree of productivity of domestic animals. The leading role in achieving the highest quality result is played by a competent choice of feed additives. The purpose of the research was to study the use of a feed additive based on biologically active substances (BAS) in the fattening of steers. The effect of the feed additive based on a natural, balanced, natural complex of biologically active substances such as vitamins B, C, PP, tryptophan (with oral administration bioavailability reaches 90 %), antioxidants, essential and free amino acids, enzymes and trace element salts on the growth and development of young cattle of Black-and-White breed has been studied. The steers of the control group received the main diet, and the animals of the experimental group in addition to the main diet received the feed additive consisting of vitamins, amino acids, antioxidants, enzymes and trace element salts. It has been found by the studies that the use of the test feed additive based on BAS provides an improvement in the digestibility and assimilation of nutrients in the diet, which contributed to the increase in the average daily live weight gain in the experimental group by 263 g or 25 %, the decrease in feed consumption for 1 kg of gain and the improvement in blood biochemical parameters, such as inorganic phosphorus, AST, ALT, alkaline phosphatase within physiological norms. In order to balance the diets of 9-monthold steers by biologically active substances and improve the physiological and biochemical status, the digestibility of nutrients that contribute to the increase in the average daily weight gain, it is recommended to use the feed additive based on BAS with drinking water.
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Alaidaroos, Bothaina A. "Isolation and Molecular Identification of Phenol Degrading Bacterium from Industrial Wastes, Collected from Jeddah Saudi Arabia." Bioscience Biotechnology Research Communications 14, no. 4 (December 25, 2021): 1992–2001. http://dx.doi.org/10.21786/bbrc/14.4.90.
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In the past two decades, phenolic compounds have had different applications, however their use in densification has increased considerably due to Covid 19. Discharge of these dangerous materials is highly toxic and causes risk and severe problems to the environment and health of human and animals, in addition to it being harmful to the aquatic life. Phenol degradation is very important due to high toxicity and stability. The aim of this study is to isolate phenol-degrading aerobic bacteria from hydrocarbon contaminated soil or wastewater, collected from the industrial area of Jeddah. Minimal medium containing phenol as carbon source was used to isolate different bacteria. About 30 actinomycete isolates were obtained, purified and preserved on Starch nitrate. Out of 30 isolates, eight isolates (27%) grow well in medium containing 0.1% phenol. After growing in broth medium, isolate BA4 and isolate BA8 were very active in phenol degradation. Growth and phenol degradation was measured in liquid medium for the two isolates. Morphological and physiological characters of these isolates were detected using different methods. Using molecular methods, they were belonging to a genus of actinomycetes. They were identified as Streptomyces flavabus BA4 and Streptomyces sp. BA8.The effects of some growth factors on growth and phenol degradation were determined. Growth was measured by dry weight (mg/l) while phenol degradation was detected by assaying the residual phenol concentration. The presence of electron donors such as glucose, starch, glycine, peptone, and Na acetate affect both growth and phenol degradation. It was clear that addition of 1 g/l peptone enhanced both growth and phenol degradation. The isolate use phenol and its derivatives m-cresol and o-cresol as carbon sources and addition of vitamin B complex increased the bacterial growth. In conclusion, phenol degradation was detected by actinobacteria and was affected by some physical and biochemical factors. It was noticed that optimization of growth conditions enhanced both growth and phenol degradation by the two selected Streptomyces isolate. Degradation process by isolate BA4 could be a promising solution for removal of phenol from wastewater.
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Fujii, Akira, Hiroko Matsumoto, and Hirotsugu Yamamoto. "Effect of vitamin B complex on neurotransmission and neurite outgrowth." General Pharmacology: The Vascular System 27, no. 6 (September 1996): 995–1000. http://dx.doi.org/10.1016/0306-3623(95)02072-1.
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Merzlenko, R. A., D. V. Kaveshnikov, A. P. Chernyavsky, V. N. Pozdnyakova, and A. N. Musokhranova. "Effect of vitamin—amino acid complex AMIVIT on physiological indices and productivity of piglets." Russian Agricultural Sciences 41, no. 4 (July 2015): 274–76. http://dx.doi.org/10.3103/s1068367415040138.
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B. ANGLO-OJEDA, AILYN, APRIL B. FLORES, and AVRIL LEY ANN V. RECTO. "Comparative Evaluation of the Anti-Angiogenic Properties of Vitamin B Complex and Ascorbic Acid using Duck Embryo Chorioallantoic Membrane (CAM) Assay." International Multidisciplinary Research Journal 4, no. 2 (June 26, 2022): 175–81. http://dx.doi.org/10.54476/8028643.
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With tens of millions of people diagnosed with cancer each year, and with the increasing attention on the use of vitamins as an important part of human health, investigating the effect of essential vitamins on angiogenesis which is a critical step in cancer development plays a significant role in fighting the disease. The study compares the effects of vitamin B complex (Vitamin B1 + B6 + B12) and ascorbic acid on angiogenesis using the Chorioallantoic Membrane (CAM) assay. The CAM of ten-day-old duck embryos were treated with various concentrations (1mg/ml, 3mg/ml, and 5mg/ml) of commercially available vitamin B complex and ascorbic acid, and the vascularization of the CAM was determined after two days of incubation. Results revealed that vitamin B complex and ascorbic acid have anti-angiogenic properties at peaks in dosages of 5mg/ml and 3mg/ml respectively. However, all concentrations of both vitamins have a significant effect on the growth of secondary blood vessels. The result of the post hoc test showed that vitamin B complex at a dosage of 5mg/ml exhibited the highest anti-angiogenic activity. Keywords: angiogenesis, anti-angiogenic, property vitamin B complex, CAM assay
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Yani, Ahmad, Muh Yusri Karim, Zainuddin, and Siti Aslamyah. "The effect of vitamin B complex and phosphorus on the RNA/DNA ratio and larval growth of barramundi (Lates calcarifer Bloch, 1790)." IOP Conference Series: Earth and Environmental Science 1119, no. 1 (December 1, 2022): 012069. http://dx.doi.org/10.1088/1755-1315/1119/1/012069.
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Abstract Barramundi (L. calcarifer) is a valuable fish with aquaculture potential. One of the factors determining the success of barramundi aquaculture is the availability of seeds, however larviculture success is often low. This research examined the effect of supplementation with various combinations of vitamin B complex and phosphorus on the RNA/DNA ratio and growth of captive-bred barramundi larvae. Barramundi larvae aged 2 days were stocked at a density of 25 fish/L and reared for 30 days with natural feed (Chlorella and rotifers) in 40 L containers filled with 30 L water. Commercial vitamin B complex and mineral phosphorus were dissolved in water and added to the larval rearing media. The research used a completely randomized factorial design with 2 factors, 4 levels and 3 replicates, giving 16 treatments and 48 experimental units. The factors were vitamin B complex (0, 75, 150, and 225 mg/L) and phosphorus (0, 0.5, 1.0, and 1.5 mg/L). Analysis of variance showed that the combination of vitamin B complex and phosphorus had a highly significant effect (p<0.01) on the RNA/DNA ratio. Barramundi larval growth was lowest with 0 mg/L of both supplements (control) and highest with 150mg/L vitamin B complex and 1.0 mg/L phosphorus, decreasing with higher levels of either additive.
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Blomhoff, H. K. "Vitamin A regulates proliferation and apoptosis of human T- and B-cells." Biochemical Society Transactions 32, no. 6 (October 26, 2004): 982–84. http://dx.doi.org/10.1042/bst0320982.
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Vitamin A is known to protect against infections, but it is not established how vitamin A metabolites stimulate the immune system. We have investigated the effects of physiological levels of retinoic acid on the function of normal human T- and B-cells. Surprisingly, we found that the proliferation of B-cells was inhibited by retinoids, and that this was due to rapid inhibition of the cell cycle machinery regulating G1-to-S transition. In contrast, the proliferation of T-cells was enhanced by physiological levels of retinoic acid, and the effect was due to induction of IL-2 (interleukin 2). The ‘non-death-receptor’-mediated apoptosis of normal T-cells induced by prolonged (but single) stimulation of the cells was also prevented by retinoid acid, and also this effect was mediated via enhanced production of IL-2. The induction of IL-2 was at the transcriptional level, and all the effects of vitamin A on both B-and T-cells were mediated via the nuclear retinoic acid receptors (RARs), and not retinoid X receptors (RXRs).
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Arisandy, Aprilianto Bayu, Agustina Widyasworo, and Eddy Trijana Sudani. "PERBEDAAN PEMBERIAN LARUTAN VITAMIN B KOMPLEKS PADA TELUR TETAS TERHADAP HASIL TETAS AYAM KAMPUNG." AVES: Jurnal Ilmu Peternakan 12, no. 1 (June 12, 2018): 31–51. http://dx.doi.org/10.35457/aves.v12i1.1502.
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ABSTRACT
The research was conducted at Mrs. Sripurwanti's farm in Rejotangan Village, Rejotangan Sub-district, Tulung Agung Regency. The research was conducted from 1 March to 1 April 2017. The aim of the research to determine the difference in the solution of Vitamin B Complex to the results of domestic chicken include hatchability, mortality and hatching weight. Research material using selected 225 eggs of chicken eggs and Vitamin B Complex as many as 30 grains. The research method used is experiments with Completely Randomized Design (RAL). The study was divided into 5 treatments and 5 replications per repeat consisting of 9 eggs. Treatment consists of the addition of Vitamin B complex as much as 0, 45 mg, 90 mg, 135 mg, and 180 mg The results are expected can provide information about alternative moisture enhancer ingredients namely Vitamin B Komplek. The results showed that vitamin B complex was not significant (P> 0.05) to hatchability, live eggs and die 2nd candling , mortality, and hatching weight. Vitamin B complex has significant effect (P <0,05) on hatchability and mortality based on candling to 2. Result of the research can be concluded that giving Vitamin B Complex as much as 45 mg deserves to be additive addition of humidity because it can increase the percentage of hatchability by 15%
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Alnahdi, Hanan S. "Hepatoprotective effect of vitamin B complex on diclofenac sodium induced liver toxicity in rats." International Journal of Academic Research 4, no. 5 (September 1, 2012): 120–29. http://dx.doi.org/10.7813/2075-4124.2012/4-5/a.15.
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Tamura, Tetsuya, Gail Otulakowski, and Brian P. Kavanagh. "Could nanotechnology make vitamin E therapeutically effective?" American Journal of Physiology-Lung Cellular and Molecular Physiology 316, no. 1 (January 1, 2019): L1—L5. http://dx.doi.org/10.1152/ajplung.00430.2018.
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Vitamin E (VitE) has important antioxidant and anti-inflammatory effects and is necessary for normal physiological function. α-Tocopherol (α-T), the predominant form of VitE in human tissues, has been extensively studied. Other VitE forms, particularly γ-tocopherol (γ-T), are also potent bioactive molecules. The effects are complex, involving both reactive oxygen and nitrogen species, but trials of VitE have been generally negative. We propose that a nanoparticle approach to delivery of VitE might provide effective delivery and therapeutic effect.
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Coburn, Stephen, Joel Stauffer, Kimberley Grobien, Beomjin Kim, and Douglas Townsend. "A Physiologically Based Pharmacokinetic (PBPK) Model of Vitamin B-6 Metabolism in the Mouse Incorporated With Visualization of Complex Compartmental Models." Current Developments in Nutrition 5, Supplement_2 (June 2021): 1307. http://dx.doi.org/10.1093/cdn/nzab059_008.
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Abstract Objectives To develop a compartmental model which describes vitamin B-6 metabolism in the blood and tissues of the mouse under a variety of circumstances and to develop a computer application which can utilize the data to display the movement of tracer through the various compartments. Methods A circulation model was developed. Literature data from vitamin B-6 feeding studies and tracer experiments were used to develop an appropriate compartmental model using the SAAM II program (The Epsilon Group, Charlottesville, VA). A web-based application transforms the mass and flux data into intuitive and interactive graphical illustrations. Results Describing the interconversions between pyridoxine, pyridoxine 5’-phosphate, pyridoxal, pyridoxal 5’-phosphate, pyridoxamine, pyridoxamine 5’-phosphate and 4-pyridoxic acid in multiple tissues required 231 compartments. The largest amount of data deals with liver and brain. The model includes less detailed information on plasma, erythrocytes, gut, bone, muscle, heart, kidney, skin, adipose tissue and lung. The model includes adjustments to food intake, water intake, cardiac output, binding sites and Vmax values for enzymes based on the specified body weight of experimental animals. We did not include growth curves at this time. The model uses two parallel systems to monitor the steady state of endogenous metabolites as well as following tracer administration. Binding mechanisms are included to provide conservation of vitamin B-6 when intake is reduced. The model provides reasonable agreement with literature data on various vitamin B-6 intakes as well as oral and intravenous administration of tracer. It also reveals some areas which need clarification. For example, we have not found any detailed analysis of vitamin B-6 metabolites in mouse urine. There is little pyridoxic acid in plasma or urine suggesting that pyridoxic acid may not be the primary end product for vitamin B-6 in the mouse. The visualization application shows changes in the content of all 231 compartments over time illustrating the value of such computer applications in the interpretation of large, complex models. Conclusions This model facilitates the simulation of various dietary and physiological conditions on vitamin B-6 metabolism in mice. We hope to adapt it to rats, pigs and humans. Funding Sources Purdue University Fort Wayne.
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Pourié, Grégory, Nicolas Martin, Jean-Luc Daval, Jean-Marc Alberto, Rémy Umoret, Jean-Louis Guéant, and Carine Bossenmeyer-Pourié. "The Stimulation of Neurogenesis Improves the Cognitive Status of Aging Rats Subjected to Gestational and Perinatal Deficiency of B9–12 Vitamins." International Journal of Molecular Sciences 21, no. 21 (October 28, 2020): 8008. http://dx.doi.org/10.3390/ijms21218008.
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A deficiency in B-vitamins is known to lead to persistent developmental defects in various organs during early life. The nervous system is particularly affected with functional retardation in infants and young adults. In addition, even if in some cases no damage appears evident in the beginning of life, correlations have been shown between B-vitamin metabolism and neurodegenerative diseases. However, despite the usual treatment based on B-vitamin injections, the neurological outcomes remain poorly rescued in the majority of cases, compared with physiological functions. In this study, we explored whether a neonatal stimulation of neurogenesis could compensate atrophy of specific brain areas such as the hippocampus, in the case of B-vitamin deficiency. Using a physiological mild transient hypoxia within the first 24 h after birth, rat-pups, submitted or not to neonatal B-vitamin deficiency, were followed until 330-days-of-age for their cognitive capacities and their hippocampus status. Our results showed a gender effect since females were more affected than males by the deficiency, showing a persistent low body weight and poor cognitive performance to exit a maze. Nevertheless, the neonatal stimulation of neurogenesis with hypoxia rescued the maze performance during adulthood without modifying physiological markers, such as body weight and circulating homocysteine. Our findings were reinforced by an increase of several markers at 330-days-of-age in hypoxic animals, such as Ammon’s Horn 1hippocampus (CA1) thickness and the expression of key actors of synaptic dynamic, such as the NMDA-receptor-1 (NMDAR1) and the post-synaptic-density-95 (PSD-95). We have not focused our conclusion on the neonatal hypoxia as a putative treatment, but we have discussed that, in the case of neurologic retardation associated with a reduced B-vitamin status, stimulation of the latent neurogenesis in infants could ameliorate their quality of life during their lifespan.
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GARG, RAVENDRA, NIRPENDRA SINGH, and ANURADHA DUBE. "Intake of nutrient supplements affects multiplication ofLeishmania donovaniin hamsters." Parasitology 129, no. 6 (November 18, 2004): 685–91. http://dx.doi.org/10.1017/s0031182004006055.
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The role of the essential nutrients, vitamins A,B (complex), C and E and iron, as prophylactic as well as supportive therapy in experimental visceral leishmaniasis (VL), was studied in hamsters. Prophylactic administration of vitamin C (50, 100 and 250 mg/kg) from day15 to day 0 (15 doses) significantly reduced the intake ofLeishmania donovaniin hamsters but had no therapeutic effect. In contrast, vitamins A,B complex and E and iron, whether used prophylactically or therapeutically, promoted parasite multiplication. The efficacy of sodium stibogluconate, a reference antileishmanial drug, was appreciably improved in animals administered prophylactically with vitamin C. However, supplementation of vitamin C during established infections resulted in reduced drug action. The results show that the prophylactic use of vitamin C may prevent the onset of leishmania infection and cautions against the indiscriminate use of nutrient supplements such as vitamin A, B complex, and E and iron in VL endemic areas.
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Vidayati, Lelly Aprilia. "PENGARUH PEMBERIAN VITAMIN B KOMPLEK TERHADAP GEJALA PREMENSTRUAL SYNDROME (PMS)." NURSING UPDATE : Jurnal Ilmiah Ilmu Keperawatan P-ISSN : 2085-5931 e-ISSN : 2623-2871 1, no. 1 (October 3, 2019): 6–14. http://dx.doi.org/10.36089/nu.v1i1.31.
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Premenstrual syndrome is stillexperienced by student, namely 32 students.According to Anityo researche (2014), theanalysis of the effect of vitamin B complexonphysical symptoms and premature psychology ofthe syndrome result in significant result, this isshown from reduced to loss of physical andpsychology complaint. From the results ofpreliminary study on the first level students ofD3 midwifery STIKES NHM there are 32 (84%)of students who experienced premenstrualsyndrome. The aim of the research is theinfluence of vitamin B complex towardsymptoms of premenstrual syndrome. The research design used preexperimental design with one group pretestposttest approach. The independent variable isvitamin B complex, while the dependent variableis students who experience premenstrualsyndrome. The population is 32 respondents andthe sample is 30 respondents. The samplingtechnique used in this study is random sampling.Data collection used questionnaires andinterviews, then analyzed using Paired t test. The average symptom of premenstrualsyndrome before being given vitamin B complexis 38.43 and after being given is 22.37. Theresult of data analysis with Paired t test showedthe value of P Value (0.000) with significancelevel α (0.05), it means value of P Value < α,meaning there is influence of vitamin B complextoward symptoms of premenstrual syndrome. thesynthesis vitamin B complex helps ofneurotransmitter in the brain so that it producesserotonin which plays a role in regulatingmental process, mood, while serotonin activityis related to premenstrual syndrome.
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Ali, Mennatallah A., Hala A. Hafez, Maher A. Kamel, Heba I. Ghamry, Mustafa Shukry, and Mohamed A. Farag. "Dietary Vitamin B Complex: Orchestration in Human Nutrition throughout Life with Sex Differences." Nutrients 14, no. 19 (September 22, 2022): 3940. http://dx.doi.org/10.3390/nu14193940.
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The importance of B complex vitamins starts early in the human life cycle and continues across its different stages. At the same time, numerous reports have emphasized the critical role of adequate B complex intake. Most studies examined such issues concerning a specific vitamin B or life stage, with the majority reporting the effect of either excess or deficiency. Deep insight into the orchestration of the eight different B vitamins requirements is reviewed across the human life cycle, beginning from fertility and pregnancy and reaching adulthood and senility, emphasizing interactions among them and underlying action mechanisms. The effect of sex is also reviewed for each vitamin at each life stage to highlight the different daily requirements and/or outcomes. Thiamine, riboflavin, niacin, pyridoxine, and folic acid are crucial for maternal and fetal health. During infancy and childhood, B vitamins are integrated with physical and psychological development that have a pivotal impact on one’s overall health in adolescence and adulthood. A higher intake of B vitamins in the elderly is also associated with preventing some aging problems, especially those related to inflammation. All supplementation should be carefully monitored to avoid toxicity and hypervitaminosis. More research should be invested in studying each vitamin individually concerning nutritional disparities in each life stage, with extensive attention paid to cultural differences and lifestyles.
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Ehmedah, Adil, Predrag Nedeljkovic, Sanja Dacic, Jelena Repac, Biljana Draskovic-Pavlovic, Dragana Vučević, Sanja Pekovic, and Biljana Bozic Nedeljkovic. "Effect of Vitamin B Complex Treatment on Macrophages to Schwann Cells Association during Neuroinflammation after Peripheral Nerve Injury." Molecules 25, no. 22 (November 19, 2020): 5426. http://dx.doi.org/10.3390/molecules25225426.
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Peripheral nerve injury (PNI) triggers a complex multi-cellular response involving the injured neurons, Schwann cells (SCs), and immune cells, often resulting in poor functional recovery. The aim of this study was to investigate the effects of the treatment with vitamin B (B1, B2, B3, B5, B6, and B12) complex on the interaction between macrophages and SCs during the recovery period after PNI. Transection of the motor branch of the femoral nerve followed by reconstruction by termino-terminal anastomosis was used as an experimental model. Isolated nerves from the sham (S), operated (O), and operated groups treated with the B vitamins (OT group) were used for immunofluorescence analysis. The obtained data indicated that PNI modulates interactions between macrophages and SCs in a time-dependent manner. The treatment with B vitamins complex promoted the M1-to M2-macrophage polarization and accelerated the transition from the non-myelin to myelin-forming SCs, an indicative of SCs maturation. The effect of B vitamins complex on both cell types was accompanied with an increase in macrophage/SC interactions, all of which correlated with the regeneration of the injured nerve. Clearly, the capacity of B vitamins to modulate macrophages-SCs interaction may be promising for the treatment of PNI.
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Klerk, Mariska, Petra Verhoef, Bert Verbruggen, Evert Schouten, Henk Blom, Gerard Bos, and Martin den Heijer. "Effect of Homocysteine Reduction by B-Vitamin Supplementation on Markers of Clotting Activation." Thrombosis and Haemostasis 88, no. 08 (2002): 230–35. http://dx.doi.org/10.1055/s-0037-1613192.
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SummaryHomocysteine may have an effect on risk of cardiovascular disease by stimulating procoagulant factors and/or impair anti-coagulant mechanisms or fibrinolysis. However, data in humans of such effects are sparse. In this intervention study, we examined the effect of homocysteine lowering by B-vitamin supplementation on prothrombin fragments 1 and 2 (F1+2), thrombin-antithrombin complex (TAT), and fibrin degradation products (D-dimer). The study comprised 118 healthy volunteers, 50 with homocysteine > 16 µmol/L and 68 with homocysteine ≤ 16 µmol/L, who were randomized to placebo or highdose B-vitamin supplements (5 mg folic acid, 0.4 mg hydroxycobalamin, and 50 mg pyridoxine) daily for 8 weeks. Although homocysteine concentrations were 27.7% (p < 0.0001) reduced in the Bvitamin group compared to the placebo group, no effect on F1+2 and TAT concentrations was observed. A 10.4% reduction was observed for D-dimer (p = 0.08).In conclusion, it appears that in healthy subjects homocysteine reduction by B-vitamin supplementation has a modest beneficial effect on clotting activation.
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Mistik, Selcuk, Emine Agadayi, and Emel Koseoglu. "The Effect of Vitamin B12, Physical and Cognitive Activity on Idiopathic Forgetfulness." Eurasian Journal of Family Medicine 10, no. 2 (June 30, 2021): 41–48. http://dx.doi.org/10.33880/ejfm.2021100201.
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Aim: In this study, we aimed to evaluate the effect of physical activity, vitamin B supplementation and mental activity on cognitive functions in middle-aged individuals with subjective forgetfulness. Methods: We included 82 people between 40-65 years of age who were admitted to Erciyes University Faculty of Medicine, Family Medicine and Neurology Departments polyclinics with the complaint of subjective forgetfulness between May 2017 and May 2018. General physical examination, blood tests including B12, folic acid level and thyroid functions were performed. In addition to the socio-demographic questionnaire, Beck Anxiety and Beck Depression Scale, Montreal Cognitive Assessment Test, Visual and Verbal Memory Tests were performed. Sixty-eight subjects were randomly allocated to 3 groups as cognitive activity, physical activity and vitamin B supplementation. The physical activity group made a minimum of half-hour brisk walk daily. The cognitive activity group was asked to solve a hooked puzzle every day. Vitamin supplement group used daily vitamin B complex. At the end of the third month, cognitive tests and B12 blood level test were repeated. Results: Improvement in cognitive functions was found only in the walking group. Long-term visual memory and verbal memory sub-test scores improved significantly in all groups. There were some differences between the groups in terms of verbal memory subtest scores. Conclusion: In people with forgetfulness, walking, puzzle and vitamin B supplementation seem to have positive effects even after a period of three months in terms of cognitive functions and memory. Keywords: dementia, cognitive activity, exercise, physical, B vitamins
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Morwal, Sandhya, and Sunanda Sharma. "Clinico-therapeutic management of ketosis in cow-a field case." Journal of Dairy, Veterinary & Animal Research 8, no. 5 (October 23, 2019): 179–80. http://dx.doi.org/10.15406/jdvar.2019.08.00264.
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This paper deals with a clinical case in a HF cow with signs of ketosis, along with owner history, clinical symptoms and laboratory findings. Milk, urine and blood sample were collected for proper diagnosis of disease. Detection of ketone bodies in urine with Rothera’s test was carried out. Therapeutic regimen was administered as per varied physiological conditions. Such medications as dextrose, steroids, vitamin B complex parenterally (all injected), along with oral gluconeogenic precursors and jaggery were administered. The case was treated successfully, with an excellent recovery.
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Stough, Con, Andrew Scholey, Jenny Lloyd, Jo Spong, Stephen Myers, and Luke A. Downey. "The effect of 90 day administration of a high dose vitamin B-complex on work stress." Human Psychopharmacology: Clinical and Experimental 26, no. 7 (September 8, 2011): 470–76. http://dx.doi.org/10.1002/hup.1229.
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Djokic, Gorica, Petar Vojvodic, Davor Korcok, Anita Agic, Anica Rankovic, Vladan Djordjevic, Aleksandra Vojvodic, et al. "The Effects of Magnesium – Melatonin - Vit B Complex Supplementation in Treatment of Insomnia." Open Access Macedonian Journal of Medical Sciences 7, no. 18 (August 30, 2019): 3101–5. http://dx.doi.org/10.3889/oamjms.2019.771.
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Insomnia means difficulty in falling asleep and/or stays asleep. Insomnia commonly leads to daytime sleepiness, lethargy, and a general feeling of being unwell. The most common treatment of insomnia includes GABAA receptor positive allosteric modulators or Melatonin agonists. Our study aimed to evaluate the efficacy of Magnesium- melatonin-vitamin B complex supplement in the treatment of insomnia. The study included 60 patients diagnosed with insomnia. The patients were randomly divided into study group (N = 30), and control group (N = 30), and study group was treated with Magnesium-melatonin-vitamin B complex (one dose contains 175 mg liposomal magnesium oxide, 10 mg Vit B6, 16 μg vit B12, melatonin 1 mg, Extrafolate-S 600 μg) once a day 1 hour before sleep, during the 3 months. The severity of insomnia symptoms was measured by self-reported Athens insomnia scale (AIS), with a cut-off score by Soldatos (AIS score ≥ 6). Mean AIS score at zero points was 14,93 ± 3,778 in the study group and 14,37 ± 4,081 in the control group (p = 0,476), indicating the compatibility of the groups, and both scores correspond to mild to moderate insomnia. Mean AIS score after 3 months of the Magnesium- melatonin- vitamin B complex supplementation was 10,50 ± 4,21 corresponding to mild insomnia, while median AIS score in the control group was 15,13 ± 3,76 which is referred to moderate insomnia, and difference among groups was significant (p = 0,000). Our founding’s indicating that 3 months of the Magnesium- melatonin-vitamin B complex supplementation has a beneficial effect in the treatment of insomnia regardless of cause.
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Markun, Stefan, Isaac Gravestock, Levy Jäger, Thomas Rosemann, Giuseppe Pichierri, and Jakob M. Burgstaller. "Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue: A Systematic Review, Meta-Analysis, and Meta-Regression." Nutrients 13, no. 3 (March 12, 2021): 923. http://dx.doi.org/10.3390/nu13030923.
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Vitamin B12 is often used to improve cognitive function, depressive symptoms, and fatigue. In most cases, such complaints are not associated with overt vitamin B12 deficiency or advanced neurological disorders and the effectiveness of vitamin B12 supplementation in such cases is uncertain. The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) is to assess the effects of vitamin B12 alone (B12 alone), in addition to vitamin B12 and folic acid with or without vitamin B6 (B complex) on cognitive function, depressive symptoms, and idiopathic fatigue in patients without advanced neurological disorders or overt vitamin B12 deficiency. Medline, Embase, PsycInfo, Cochrane Library, and Scopus were searched. A total of 16 RCTs with 6276 participants were included. Regarding cognitive function outcomes, we found no evidence for an effect of B12 alone or B complex supplementation on any subdomain of cognitive function outcomes. Further, meta-regression showed no significant associations of treatment effects with any of the potential predictors. We also found no overall effect of vitamin supplementation on measures of depression. Further, only one study reported effects on idiopathic fatigue, and therefore, no analysis was possible. Vitamin B12 supplementation is likely ineffective for improving cognitive function and depressive symptoms in patients without advanced neurological disorders.
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Shlenkina, T. M., E. M. Romanova, V. V. Romanov, and V. N. Lyubomirova. "IMMUNOMODULATING PROPERTIES OF A NUMBER OF BIOLOGICALLY ACTIVE FEED ADDITIVES." Vestnik of Ulyanovsk state agricultural academy 212 (December 25, 2021): 130–35. http://dx.doi.org/10.18286/1816-4501-2021-4-130-135.
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The article presents results of the studies on assessment of the effect of a number of biologically active feed additives on leukocyte formula structure of African sharptooth catfish. The biologically active feed additives under study were: "Irkutin" adaptogen, "Sporothermin" probiotics and "Chiktonik" vitamin - amino acid complex. Until recently, adaptogenes have not been used in fish feeding, but they are widely used in medicine to increase nonspecific resistance and resistance to stress. We evaluated the effect of the adaptogenes on leukocyte formula structure of African sharptooth catfish. The effect of "Chiktonik" vitamin-amino acid complex and "Sportermin" probiotics based on B. subtilis and B. licheniformis bacteria on the leukocyte formula of African catfish was also evaluated. The probiotics was used to regulate the microbiocenosis of fish gastrointestinal tract. The vitamin-amino acid complex was used to improve fish metabolism. In the course of the work, it was found that "Irkutin" adaptogene had the most pronounced effect on leukocyte formula structure among all the studied biologically active feed ingredients. Analysis of the leukocyte formula in case of usage of biologically active feed ingredients revealed activation of the phagocytic link. In case of application of each of the biologically active feed ingredients, a specific redistribution of the content of lymphocytes, neutrophils, monocytes and other cells in the leukocyte formula of African catfish took place. The research results showed that biologically active feed ingredients: "Irkutin" adaptogene, "Sportermin" probiotics, "Chiktonik" vitamin-amino acid complex showed an immunomodulatory effect.
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Fardet, Anthony. "New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?" Nutrition Research Reviews 23, no. 1 (June 2010): 65–134. http://dx.doi.org/10.1017/s0954422410000041.
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Epidemiological studies have clearly shown that whole-grain cereals can protect against obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety, reduced transit time and glycaemic response), fibre (improved faecal bulking and satiety, viscosity and SCFA production, and/or reduced glycaemic response) and Mg (better glycaemic homeostasis through increased insulin secretion), together with the antioxidant and anti-carcinogenic properties of numerous bioactive compounds, especially those in the bran and germ (minerals, trace elements, vitamins, carotenoids, polyphenols and alkylresorcinols), are today well-recognised mechanisms in this protection. Recent findings, the exhaustive listing of bioactive compounds found in whole-grain wheat, their content in whole-grain, bran and germ fractions and their estimated bioavailability, have led to new hypotheses. The involvement of polyphenols in cell signalling and gene regulation, and of sulfur compounds, lignin and phytic acid should be considered in antioxidant protection. Whole-grain wheat is also a rich source of methyl donors and lipotropes (methionine, betaine, choline, inositol and folates) that may be involved in cardiovascular and/or hepatic protection, lipid metabolism and DNA methylation. Potential protective effects of bound phenolic acids within the colon, of the B-complex vitamins on the nervous system and mental health, of oligosaccharides as prebiotics, of compounds associated with skeleton health, and of other compounds such as α-linolenic acid, policosanol, melatonin, phytosterols andpara-aminobenzoic acid also deserve to be studied in more depth. Finally, benefits of nutrigenomics to study complex physiological effects of the ‘whole-grain package’, and the most promising ways for improving the nutritional quality of cereal products are discussed.
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Bakleicheva, Margarita O., Irina V. Kovaleva, Olesya N. Bespalova, and Igor Yu Kogan. "The effect of vitamin D on women’s reproductive health." Journal of obstetrics and women's diseases 67, no. 3 (December 15, 2018): 4–19. http://dx.doi.org/10.17816/jowd6734-19.
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Background. According to WHO data (2014), more than two billion people are deficient in microelements or have a “hidden hunger” due to the deficiencies of vitamins and minerals. Currently, experts estimate the vitamin D deficiency as a new type of pandemic of the XXI century.
Aim. The current analysis was undertaken to evaluate the effect of vitamin D on women’s reproductive health.
Materials and Methods. Based on the findings of retrospective and prospective studies, meta-analyzes, and material trials over the past 20 years, as well as in accordance with the results of 290 prospective cohort randomized trials, the level of vitamin D affects 172 basic physiological indicators associated with the risk of such complications of pregnancy as miscarriage, preeclampsia, gestational diabetes mellitus, and bacterial vaginosis.
Results. Vitamin D has been shown to be able to act as an immune regulator during the implantation. The placenta produces and responds to vitamin D, which has a local anti-inflammatory response and simultaneously induces the production of decidual growth factors for successful pregnancy. Activated T- and B-lymphocytes have the vitamin D receptors and therefore 1,25(OH)2D is an effective modulator in the immune system. It is able to inhibit the proliferation of Th1 and to restrict the production of such cytokines as interferon-gamma (IFN-γ), interleukin-2 (IL-2), and tumor necrosis factor-alpha (TNF-α). In addition, vitamin D is able to induce cytokines of Th2 that have the protective effect on pregnancy.
Conclusion. Adequate vitamin D intake is important for the successful conception and prolongation of pregnancy, as well as for the health of the fetus and newborn.
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Vasilevich, Fedor I., Valentina M. Bachinskaya, and Yulia V. Petrova. "Influence of the vitamin-microelement complex on the biological usefulness of meat." Veterinariya, Zootekhniya i Biotekhnologiya 7, no. 104 (2022): 28–35. http://dx.doi.org/10.36871/vet.zoo.bio.202207004.
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On the domestic market of feed additives, we note a steady growth of new mineral and vitamin supplements, which differ in their composition and cost. The development and introduction into veterinary practice of feed additives that have a positive effect on the physiological state of the animal organism, contribute to an increase in average daily weight gain, safety, and also do not affect the quality and safety of livestock products is relevant for the manufacturer and animal husbandry. The article presents the results of a study of the vitamin-microelement complex «Trivit + Abioiodoselen» for broiler chickens of the Cobb-500 cross, according to the proposed scheme from 2 days of age to 5 days of age and from 15 days to 18 days of age at a dose of 1 ml per 1 liter of water. The introduction of this drug to broiler chickens in drinking water has a positive effect on the body of the bird, contributes to an increase in muscle tissue of selenium – by 12,8 %, iron – by 50,8 % in relation to the control group of broiler chickens. An increase in essential amino acids was noted in the experimental group of histidine– by 0,4 %; leucine + isoleucine– by 1,6 %; lysine – by 1,2 % and threonine – by 0,6 %, non-essential amino acids increased by 0,3 % tyrosine, 0,4 % serine and 9,0 % glutamate.
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Sarkar, Tukki, Samya Banerjee, and Akhtar Hussain. "Significant photocytotoxic effect of an iron(iii) complex of a Schiff base ligand derived from vitamin B6and thiosemicarbazide in visible light." RSC Advances 5, no. 37 (2015): 29276–84. http://dx.doi.org/10.1039/c5ra04207k.
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An iron(iii)–Schiff base complex derived from vitamin B6and thiosemicarbazide is significantly photocytotoxic to HeLa cancer cells in visible light (400 nm–700 nm) but non-toxic in the absence of light.
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Reyes-Garcı́a, Gerardo, Roberto Medina-Santillán, Flavio Terán-Rosales, Eduardo Mateos-Garcı́a, and Carlos Castillo-Henkel. "Characterization of the potentiation of the antinociceptive effect of diclofenac by vitamin B complex in the rat." Journal of Pharmacological and Toxicological Methods 42, no. 2 (October 1999): 73–77. http://dx.doi.org/10.1016/s1056-8719(00)00045-9.
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Liao, Robert S., Robert P. Rennie, and James A. Talbot. "Assessment of the Effect of Amphotericin B on the Vitality of Candida albicans." Antimicrobial Agents and Chemotherapy 43, no. 5 (May 1, 1999): 1034–41. http://dx.doi.org/10.1128/aac.43.5.1034.
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ABSTRACT The processes involved in cell death are complex, and individual techniques measure specific fractions of the total population. The interaction of Candida albicans with amphotericin B was measured with fluorescent probes with different cellular affinities. These were used to provide qualitative and quantitative information of physiological parameters which contribute to fungal cell viability. SYBR Green I and 5,(6)-carboxyfluorescein were used to assess membrane integrity, and bis-(1,3-dibutylbarbituric acid)trimethine oxonol and 3,3-dihexyloxacarbocyanine iodide were used to evaluate alterations in membrane potential. The fluorescent indicators were compared with replication competency, the conventional indicator of viability. By using these tools, the evaluation of the response of C. albicans to amphotericin B time-kill curves delineated four categories which may represent a continuum between alive and dead. The data showed that replication competency (CFU per milliliter) as determined by conventional antifungal susceptibility techniques provided only an estimate of inhibition. Interpretation of fluorescent staining characteristics indicated that C. albicans cells which were replication incompetent after exposure to greater than 0.5 μg of amphotericin B per ml still maintained degrees of physiological function.
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Otocka-Kmiecik, Aneta, and Aleksandra Król. "The Role of Vitamin C in Two Distinct Physiological States: Physical Activity and Sleep." Nutrients 12, no. 12 (December 21, 2020): 3908. http://dx.doi.org/10.3390/nu12123908.
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This paper is a literature overview of the complex relationship between vitamin C and two opposing physiological states, physical activity and sleep. The evidence suggests a clinically important bidirectional association between these two phenomena mediated by different physiological mechanisms. With this in mind, and knowing that both states share a connection with oxidative stress, we discuss the existing body of evidence to answer the question of whether vitamin C supplementation can be beneficial in the context of sleep health and key aspects of physical activity, such as performance, metabolic changes, and antioxidant function. We analyze the effect of ascorbic acid on the main sleep components, sleep duration and quality, focusing on the most common disorders: insomnia, obstructive sleep apnea, and restless legs syndrome. Deeper understanding of those interactions has implications for both public health and clinical practice.
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Samatar, Aisha A., Nahla A. Yossif, Hawazin H. Eltoum, Mohamed Qaje Adan, Ismail Adam Arbab,, Bdria Abdalla Hassan, and Ali Jimale Mohamed. "The Effect of Helicobacter pylori Infection on Vitamin B12 and Some Hematological Parameters among Sudanese Individuals: A Case-Control Study." Saudi Journal of Medicine 7, no. 12 (December 14, 2022): 621–24. http://dx.doi.org/10.36348/sjm.2022.v07i12.004.
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Background: Helicobacter Pylori (H. pylori) infection is a major gastric infection worldwide and has been associated with many hematologic disorders. Objective: The purpose of this study was to determine the effect of H. pylori infection on Sudanese people. Method: Blood samples are collected from 60 persons; 30 patient (as sample) and 30 patients (as control sample). Vitamin B12 and complete blood count (CBC) tests are performed. Results: The results revealed that Vitamin B 12 level mean was significantly lower among H. pylori patients than the controls (p-value 0.013). The results also revealed that there are no significant differences between gander in vitamin B12 level among patients. The correlation between vitamin B12 and age was found to be negative (R=0.444 & P=0.014). Conclusion & Recommendations: Vitamin B12 level, HB and RBC are lower in H. pylori infected Sudanese individuals compared to the normal people. Thus, we highly recommend for further research and case-control studies in discovering the causal factors related to reduction of vitamin B12 among H. pylori infected Sudanese individuals.
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Gay, Olivia Teresa Gonzalez, Roberto Rodriguez Labrada, Luis Velázquez Perez, Yaimee Mojena Vazquez, Raul Rodriguez Aguilera, Nalia Canales Ochoa, Yenisey Coira Moreno, Yoenis Figueredo, and Jacqueline Medrano Montero. "Effect of B-Vitamin Therapy on Painful Muscle Cramps in Preclinical Carriers of Spinocerebellar Ataxia Type 2." International Journal of Psychophysiology 168 (October 2021): S188—S189. http://dx.doi.org/10.1016/j.ijpsycho.2021.07.515.
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Shlenkina, T. M., E. M. Romanova, V. V. Romanov, and L. A. Shadyeva. "INFLUENCE OF COMPONENTS OF BIOLOGICALLY ACTIVE ADDITIVE FOR FUNCTIONAL FEEDING COMPLEXES ON FISH BLOOD PARAMETERS." Vestnik of Ulyanovsk state agricultural academy 212 (December 25, 2021): 124–29. http://dx.doi.org/10.18286/1816-4501-2021-4-124-129.
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The aim of the work was to study red and white blood composition of African sharptooth catfish, reared with application of innovative biotechnology elements, which involve usage of a complex of biologically active components, including Irkutin adaptogen, Sporothermin probiotics and Chiktonik vitamin and amino acid complex. Irkutin adaptogen was used to increase fish organism resistance to unfavorable environmental factors. Sporothermin probiotics was applied as an immunomodulatory agent to increase immunity, reduce the negative effects of stress factors, prevent infections, and regulate microbiocenosis. Chiktonik vitamin - amino acid complex was considered as a source of vitamins and amino acids, which the fish organism desperately needs when reared in recirculating aquaculture system. The object of the study was sexually mature males and females of African sharptooth catfish. The tasks of the work included assessment of the fish blood system reaction to components of our functional feed additive. The results of the research showed that application of Irkutin adaptogen in rearing of African catfish had an activating effect on the level of erythrocytes, leukocytes and hemoglobin content in the fish blood. Usage of Sporothermin probiotics also had a conspicuous effect on the content of blood corpuscles and hemoglobin content. However, Chiktonik vitamin-amino acid complex had the strongest activating effect on blood parameters, all parameters were significantly higher than in case of application of other biologically active components. The activating effect of each biologically active component did not go beyond the physiological norm.
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Solyanik, A. V., V. G. Semenov, V. G. Tyurin, A. F. Kuznetsov, V. G. Sofronov, A. Kh Volkov, V. V. Solyanik, S. V. Solyanik, and V. A. Solyanik. "The effect of fumaric acid, dipromonium and vitamin C on the productivity of sows." IOP Conference Series: Earth and Environmental Science 935, no. 1 (December 1, 2021): 012023. http://dx.doi.org/10.1088/1755-1315/935/1/012023.
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Abstract The article presents the results of the effect of fumaric acid, dipromonium and vitamin C on productivity, physiological state and natural resistance of sows. The scientific and economic experience was carried out at the pig-breeding complex with a production capacity of 27 thousand heads “Voskhod” in the Mogilev region of Belarus. Forty primiparous gilts were divided into four groups (n = 10): a control and three experimental groups. Experimental gilts received basal diet supplemented with fumaric acid (4.0 g/kg of dry matter), dipromonium (0.4 g/kg) or vitamin C (0.1 g/kg) from 1 to 20 d of lactation. The animals of the control group did not receive the indicated preparation. The use of additives contributed to an increase in the milk yield of pigs, the viability of piglets and their growth rate by 21.1-30.0% (P<0.05), 6.0-6.6 and 10.0-27.9%, respectively, as well as influenced the morphological, biochemical and immunological parameters of the blood of pigs and their progeny.
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Anino, Calvince, Arnold Onyango, Samuel Imathiu, and Julius Maina. "Effect of Lactic Acid Bacteria Starter Cultures on Vitamin and Oligosaccharide Composition of Milk Extracted from Three Common Bean (Phaselous Vulgaris L) Varieties." Journal of Food Research 8, no. 3 (May 7, 2019): 103. http://dx.doi.org/10.5539/jfr.v8n3p103.
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Fermented foods have in recent times attracted consumer interest mainly due to perceived health benefits of probiotic microorganisms. This study characterized changes in the concentrations of selected B-complex vitamins and oligosaccharides of common bean milk during fermentation by a common dairy starter culture, YF L-903 (Streptococcus thermophilus + Lactobacillus Bulgaricus subs Debulgaricus), and three probiotic cultures namely ABT (Lactobacillus acidophilus La-5 + Bifidobacterium animalis Bb-12 + Streptococcus thermophilus), Yoba (Lactobacillus rhamnosus yoba + Streptococcus thermophilus), and Yoba Fiti (Lactobacillus rhamnosus GR1 + Streptococcus thermophilus). Bean milk was prepared from three common bean varieties. It was found that, apart from thiamine (vitamin B1) and riboflavin (vitamin B2), fermentation with each of the mixed cultures caused significant increase in the vitamin B complex. Significant reductions (p<0.05) in the oligosaccharides concentration of the bean milks were observed upon fermentation. Highest reduction in the oligosaccharide sugars of 77.8% was found in milk from pinto bean variety fermented with ABT culture. These findings suggest that LAB probiotic cultures have a potential for improving biosynthesis of vitamins and removal of the verbascose, stachyose and raffinose oligosaccharides, thus making the product more digestible and the nutrients more bioavailable.
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Lewis, John E., Eduard Tiozzo, Angelica B. Melillo, Susanna Leonard, Lawrence Chen, Armando Mendez, Judi M. Woolger, and Janet Konefal. "The Effect of Methylated Vitamin B Complex on Depressive and Anxiety Symptoms and Quality of Life in Adults with Depression." ISRN Psychiatry 2013 (January 21, 2013): 1–7. http://dx.doi.org/10.1155/2013/621453.
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Depression, the most common type of mental illness, is the second leading cause of disability and is increasing among Americans. The effect of improved nutrition, particularly with dietary supplements, on depression may provide an alternative to standard medical treatment. Some studies have shown that certain nutrients (e.g., inositol and S-adenosyl methionine) are effective at improving depressed mood, although the results are not unequivocal. The current study was a randomized, double-blind, placebo-controlled trial to evaluate the efficacy of a vitamin B complex nutritional supplement (Max Stress B) for improving depressive and anxiety symptoms according to the Beck Depression and Anxiety Inventories (BDI and BAI) in 60 adults diagnosed with major depression or other forms of depressive disorders. Secondary outcomes included quality of life according to the SF-36. Participants were assessed at baseline and 30- and 60-day followups. Max Stress B showed significant and more continuous improvements in depressive and anxiety symptoms, compared to placebo. Additionally, Max Stress B showed significant improvement on the mental health scale of the SF-36 compared to placebo. Thus, we showed modest utility of Max Stress B to improve mood symptoms and mental health quality of life in adults with depression.
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Blackman, Alison, Alyssa Boutin, Alexei Shimanovsky, William J. Baker, and Nicholas Forcello. "Levocarnitine and vitamin B complex for the treatment of pegaspargase-induced hepatotoxicity: A case report and review of the literature." Journal of Oncology Pharmacy Practice 24, no. 5 (May 19, 2017): 393–97. http://dx.doi.org/10.1177/1078155217710714.
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Asparaginase is a chemotherapeutic agent that is commonly used in combination with other medications for the treatment of acute lymphoblastic leukemia. An adverse effect of asparaginase includes hepatotoxicity, which can lead to severe liver failure and death. Several reports have documented successful treatment of asparaginase-induced hepatotoxicity using levocarnitine (l-carnitine) and vitamin B complex. Herein, we report a patient with acute lymphoblastic leukemia that experienced acute liver injury following pegaspargase administration. Our patient was successfully treated with l-carnitine and vitamin B complex for 8 days and achieved recovery of hepatic function. Furthermore, we review the current literature and provide a recommendation on a regimen that can be used as an option for the treatment of asparaginase-induced hepatic injury.
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., Nurfadilah, Ruqayyah Jamaluddin, and Muhammad Yusri Karim. "The Effect of Vitamin B Complex on Survival, Growth and Stress Resistance of Nile Tilapia (Oreochromis niloticus) Larvae." International Journal of Scientific and Research Publications (IJSRP) 11, no. 11 (November 12, 2021): 237–42. http://dx.doi.org/10.29322/ijsrp.11.11.2021.p11929.
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Ganguly, S., and A. K. Banik. "Effect of Vitamin B-complex on Growth and L-glutamic acid Accumulation by a Mutant Micrococcus glutamicus AB100." Biosciences Biotechnology Research Asia 8, no. 2 (December 30, 2011): 753–58. http://dx.doi.org/10.13005/bbra/930.
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Ghasemi, Shima, Amirreza Babaloo, Mehrnoosh Sadighi, Zeinab Torab, Hamidreza Mohammadi, and Elshan Khodadust. "Effect of vitamin B complex administration on pain and sensory problems related to inferior alveolar nerve damage following mandibular implant placement surgery." Journal of Advanced Periodontology & Implant Dentistry 14, no. 1 (May 30, 2022): 13–19. http://dx.doi.org/10.34172/japid.2022.007.
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Background. Inferior alveolar nerve damage can lead to mild to severe paresthesia and even facial pain. One of the treatments considered today for the reconstruction and treatment of damaged peripheral nerves is the use of vitamin supplements. This study aimed to evaluate the effect of vitamin B complex supplementation on pain and sensory problems following mandibular implant placement surgery. Methods. In this single-blind clinical trial, 46 patients applying for implant placement, who were eligible for the study, were evaluated. All the patients were examined for sensory facial injury and inferior alveolar nerve injury within 24 hours after implant placement. The nerve damage was recorded by AI (asymmetry index) in the initial examination. Patients who reported clinical and radiographic signs of nerve damage due to implant or drill impingement of the nerve canal were excluded from the study and promptly treated with anti-inflammatory protocols. Then the patients were randomly divided into control (n=23) and intervention (n=23) groups. Patients in the control group received routine treatment after implantation, and patients in the intervention group received vitamin B complex pills in addition to routine treatment. A placebo was used to eliminate the inductive effect of the drug in the control group. Follow-up of patients was performed at intervals of 14 days and 1, 2, and 3 months after treatment. Data analysis was performed using SPSS 24 and Kruskal-Wallis, Wilcoxon, and chi-squared tests. Results. In both groups, a decreasing trend in pain intensity was observed for up to three months. There were no significant differences between the mean pain intensity in the intervention and control groups at all the follow-up intervals. In both groups, a decrease in the rate of paresthesia was observed during the 3-month follow-up. The mean of paresthesia in the two groups was not significantly different at any follow-up interval. Conclusion. Vitamin B complex might not affect pain intensity and paresthesia after implant surgery.
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Mikkelsen, Kathleen, Monica D. Prakash, Nyanbol Kuol, Kulmira Nurgali, Lily Stojanovska, and Vasso Apostolopoulos. "Anti-Tumor Effects of Vitamin B2, B6 and B9 in Promonocytic Lymphoma Cells." International Journal of Molecular Sciences 20, no. 15 (August 1, 2019): 3763. http://dx.doi.org/10.3390/ijms20153763.
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Chronic inflammation can lead to tumour initiation and progression. Vitamin B complex has the ability to regulate the immune response and, therefore, inflammation but many of the mechanistic and molecular processes involved in this regulation are still not fully understood. This study sought to determine some of these processes by studying the effects of vitamin B2 (riboflavin) B6 (pyridoxine) and B9 (folic acid) on un-differentiated pro-monocytic lymphoma cells in regard to their ability to alter the proliferation, migration, apoptosis, cytokines and expression levels of programmed death ligand 1. We show that vitamin B2, B6 and B9, on pro-monocytic lymphoma cells exerted an anti-tumorigenic effect. This data could form the basis for future studies in using vitamin B supplementation to reduce cancer cell growth in vivo.
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Justo, Rayssa, Marcelo Cesar, Edimilson Migowski, and Rafael Cisne. "Relation between vitamins of the b complex, GABA and glutamate, and their role in neurocognitive disorders -Brief review." International Journal of Basic and Applied Sciences 5, no. 4 (November 29, 2016): 229. http://dx.doi.org/10.14419/ijbas.v5i4.6707.
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Vitamins, especially the water-soluble complex of vitamins B, are highlighted in the daily clinical practice. Numerous studies emphasize the need for supplementation, mainly in groups with deficiency of these vitamins, such as the elderly, pregnant women, children and patients with diseases associates with cognitive disorder. Thiamine (B1), a vitamin of the diet, is an important cofactor for the three key enzymes involved in the citric acid cycle and the pentose phosphate cycle. Pyridoxine (B6) and cobalamin (B12) act in the CNS as a cofactor in the metabolism reactions of homocysteine. Deficiency of some neurotransmitter precursors can also cause symptoms of attention deficit hyperactivity disorder in children, especially amino acid and vitamin B deficiency. Inhibitory and excitatory neurotransmitters regulate diverse behavioral processes, including sleep, learning, memory and sensation of pain. They are also implicated in many pathological processes, such as epilepsy and neurotoxicity. Studies suggest that the excitatory amino acids may play a role in learning and memory. The binding of glutamate to its receptor triggers molecular and cellular events associated with numerous physiological and pathophysiological pathways, including the development of an increased sensation of pain (hyperalgesia), brain neurotoxicity or synaptic alterations involved in certain types of memory formation. Between the two major classes of neuroactive amino acids, γ-aminobutyric acid (GABA) is the major inhibitory amino acid. It is known that GABA plays a fundamental role in encoding information and behavioral control, in the regulation of motor function and in motor learning. The inter-relationships between diet, the brain and behavior are complex. However, micronutrients are known to have a direct influence on cognitive function through their involvement in the energy metabolism of neurons and glia cells, the synthesis of neurotransmitters, receptor binding and the maintenance of membrane ion pumps.