Journal articles on the topic 'Vitamin A deficiency'
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McDowell, L. R. "Vitamin nutrition of livestock animals: Overview from vitamin discovery to today." Canadian Journal of Animal Science 86, no. 2 (June 1, 2006): 171–79. http://dx.doi.org/10.4141/a05-057.
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The term “vitamin” or “vitamine” was first used in 1912. What later became known as vitamin deficiency diseases — scurvy, beriberi, night blindness and xeropthalmia — had plagued the world from antiquity. From 1900 through the 1930s, experiments with animals helped to advance knowledge of vitamins considerably. There are 15 vitamins of significance for livestock. A number of factors influence vitamin requirements and vitamin utilization, including physiological make-up and production function; confinement rearing without pasture; stress, disease and adverse environmental conditions; vitamin antagonists; use of antimicrobial drugs; and body vitamin reserves. Under commercial livestock and poultry production conditions, vitamin allowances higher than National Research Council (USA) requirements may be needed for optimum performance. Generally, the optimum vitamin supplementation level is the quantity that achieves the best growth rate, feed utilization and health (including immune competency), while also providing adequate body reserves. Key words: Vitamins, history, deficiency, requirements, supplementation
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Pusparini, Pusparini. "DEFISIENSI VITAMIN D TERHADAP PENYAKIT (Vitamin D Deficiency and Diseases)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 21, no. 1 (April 15, 2018): 90. http://dx.doi.org/10.24293/ijcpml.v21i1.1265.
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It has been estimated that deficiency and insufficiency of Vitamin D affect one bilion people worldwide. Vitamin D deficiency can befound not only in countries with four (4) seasons, but also in countries with sunlight exposure all year long The objective of this studywas to know whether vitamin D deficiency can occur in Indonesia as well and to explore the role of vitamin D in people‘s health, althoughIndonesia is a country in the equator region. To avoid long term negative health consequences 25 hydroxyvitamin D/25 (OH) D serumlevel should be between 30 and 100 ng/mL. The main source of vitamin D is by synthesis at the skin which is exposed to ultraviolet Bradiation. The other source of vitamin D is from food. There are a lot of causes of vitamin D deficiency, for example: decreased vitaminD synthesis, nutritional intake of vitamin D, maternal vitamin D stores and exclusive breastfeeding, mal absorption and decreasedsynthesis or increased degradation of 25 (OH) D. From the above factors, decreased vitamin D synthesis is the main cause of vitamin Ddeficiency. The vitamin D deficiency is estimated and plays an important role in multiple disorders, such as: osteoporosis, fracture, cancer,cardiovascular disease, diabetes mellitus, autoimmune disease and infectious disease. A good strategy in managing vitamin D deficiencyis needed in order to solve the related problems.
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Fahad Aldaihani, Saad. "VITAMIN DEFICIENCY AND FOOD SUPPLEMENTS." International Journal of Advanced Research 9, no. 12 (December 31, 2021): 540–52. http://dx.doi.org/10.21474/ijar01/13941.
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Vitamins are a heterogeneous group of organic compounds that help ensure the human bodys wellbeing and function. This paper introduces the importance of all vitamins, both water-soluble and fat-soluble, as well as problems deriving from their deficiency. Additionally, vitamin supplements as part of treating vitamin deficiency, and possible harmful effects on the human body areshowcased. The main focus of the paper is on the vitamin B complex, and vitamin B12 specifically. The benefits of vitamin B12, as well as its action in the human body and the noxious effects of any lack of vitamin B12 in the human body, are also discussed. Some of the health conditionsan individual may need to face when they have vitamin B12 deficiency include neural tube defects, Alzheimers disease, depression, and megaloblastic anaemia, which are also introduced and further discussed, in terms of symptomatology, causes and suggested treatment. The toxicity of vitamin B12 is also introduced, and possible causes for vitamin B12 deficiency are showcased.
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MIHĂESCU, Victoria-Mădălina, Raluca-Ioana DASCĂLU, Andra Ioana NUȚĂ, and Luminița-Bianca GROSU. "DEFICIENCY AND TOXICITY OF VITAMINS." Annals of the Academy of Romanian Scientists Series of Medicine 4, no. 1 (2023): 38–48. http://dx.doi.org/10.56082/annalsarscimed.2023.1.38.
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Vitamins are substances necessary to sustain life, with many functions. Vitamins must be obtained from food, as they are either not made in the body at all or are not made in sufficient quantities for growth, vitality and wellbeing. Lack of a particular vitamin can lead to incomplete metabolism, fatigue and other important health problems. Deficiency of a vitamin causes symptoms which can be cured by that vitamin. Large doses of vitamins may slow or ever reverse diseases such as cancer, osteoporosis, nerve degeneration and heart disease.
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Varsamis, Nikolaos, Georgios A. Christou, Christos Derdemezis, Alexandros Tselepis, and Dimitrios Kiortsis. "The Associations of Dietary Vitamin K Intake and Circulating Vitamin 25(OH)D with Serum Lipoprotein Levels: The Vitamin Deficiency Matters." Hormone and Metabolic Research 55, no. 03 (February 27, 2023): 196–204. http://dx.doi.org/10.1055/a-2020-2080.
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AbstractA synergistic interplay between vitamins K and D appears to exist. We aimed to investigate for the first time whether the associations of dietary vitamin K intake and circulating 25(OH)D with serum lipoprotein levels are influenced by the existence of deficiency of either or both vitamins K and D. Sixty individuals [24 males, 36(18–79) years old] were examined. Vitamin deficiency of K1 and D were defined as vitamin K1 intake/body weight (BW)<1.00 μg/kg/day and circulating 25(OH)D<20 ng/ml, respectively. In individuals with vitamin K1 deficiency, the vitamin K1 intake/BW correlated positively with high density lipoprotein-cholesterol (HDL-C) (r=0.509, p=0.008) and negatively with serum triglycerides (TG) (r=–0.638, p=0.001), whereas circulating 25(OH)D correlated negatively with TG (r=–0.609, p=0.001). In individuals with vitamin D deficiency, the vitamin K1 intake/BW correlated positively with HDL-C (r=0.533, p=0.001) and negatively with TG (r=–0.421, p=0.009), while circulating 25(OH)D correlated negatively with TG (r=–0.458, p=0.004). The above-mentioned associations of vitamin K1 intake/BW and circulating 25(OH)D with serum lipoproteins were not detected in individuals without vitamin K1 deficiency or the ones without vitamin D deficiency. The vitamin K2 intake/BW correlated negatively with low density lipoprotein-cholesterol (LDL-C) (r=–0.404, p=0.001). In conclusion, the associations of vitamin K1 intake with TG and HDL-C and of circulating 25(OH)D with TG were more pronounced in individuals with deficiency of either or both vitamins K1 and D. Increased dietary vitamin K2 intake was associated with decreased LDL-C.
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Lakho, Arshad Sattar, Aqeel Ahmed Channa, Abdul Ghaffar Dars, Syed Zulfiquar Ali Shah, and Muhammad Iqbal. "VITAMIN B12 DEFICIENCY." Professional Medical Journal 25, no. 05 (May 7, 2018): 753–58. http://dx.doi.org/10.29309/tpmj/18.4438.
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Butt, Maleeha Tahir, Amber Shami, Waqas Qarshi, Raheela Shaheen, Zarrin Khaliq Chaudari, and Mehak Shafiq. "Vitamin D Deficiency as Etiological Factor for Breast Cancer." Pakistan Journal of Medical and Health Sciences 16, no. 8 (August 30, 2022): 836–38. http://dx.doi.org/10.53350/pjmhs22168836.
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Aim: To determine the association between vitamin D deficiency and breast cancer. Material and methods: This study was conducted on 72 participants, 36 cases and 36 healthy controls were enrolled. Basic demographic information was recorded. Vitamins D deficiency was assessed between both groups. Serum Vitamin D level < 20 ng/ml was considered as vitamin D deficient. Results: Mean age in the cases was 34.64±9.14 years and 36.22±8.78 years in controls. Significant association was found between vitamins D deficiency and breast cancer. In cases there 28 (77.7%) patients with vitamin D deficient and in controls 15 (41.7%) patients. Conclusion: Vitamin D deficiency is a major risk factor for breast cancer.
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Khrulev, Aleksej E., Alina N. Baykina, Natal’ya A. Shiyanova, Anna Yu Sirotkina, Ol’ga Yu Salokhina, and Vera N. Grigorieva. "Status of water-soluble vitamins and neurological disorders in dialysis patients." Neurology Bulletin LII, no. 1 (June 23, 2020): 55–59. http://dx.doi.org/10.17816/nb17771.
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The deficit of vitamins in patients receiving the long-term hemodialysis is discussed in the modern literature. Vitamin deficiency in a dialysis patient can be explained by the peculiarity of the diet recommendations, the need to take a number of medications, impaired absorption of vitamins in the digestive tract, poor appetite, uremic anorexia, depression, limited ability to buy and cook food, as well as losses of vitamins during the procedure of program hemodialysis. An analytical review of current (2011 and later) publications containing a comprehensive analysis of data on the status of water-soluble vitamins and its role in the development of neurological disorders in dialysis patients is provided. There is a high risk of deficiency of various water soluble vitamins and neurological disorders, such as vitamin B1 deficiency and thiamine deficiency encephalopathy and polyneuropathy, vitamin B6 deficiency and pyridoxine deficiency polyneuropathy, folic acid metabolism disorders, as well as vitamin B12 and the development of hyperhomocysteinemia, cognitive and depressive disorders, strokes, restless legs syndrome and dialysis polyneuropathy among the patients with end-stage chronic kidney disease and program hemodialysis. Vitamin C deficiency and the development of severe asthenic syndrome with insomnia and depression are described in dialysis patients. It seems necessary to revise the traditional nutritional approaches to the dialysis patients based on the analysis of the literature. Special attention is paid to the possible addition of such water-soluble vitamins as B1, B6, B9, B12 and C. Timely diagnosis of vitamin deficiency conditions and neurological disorders in patients on program hemodialysis, the development of methods for their correction and their introduction into clinical practice would improve the life expectancy and quality of life of dialysis patients.
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Abeer Talib Abdulqader. "Effects of vitamin deficiency (A, C and D) in maternal on the weights of newborns." Tikrit Journal of Pure Science 23, no. 1 (April 1, 2018): 9–12. http://dx.doi.org/10.25130/tjps.v23i1.472.
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The present study was designed to find the relation between vitamin deficiency (A, C and D) of maternal and the weights of newborns. The study used 50 volunteers (40 pregnant women with vitamins deficiency and 10 pregnant women without vitamins deficiency). Pregnant women were divided to two groups according to vitamins state. Newborn weights directly were reported at birth time. Vitamins levels showeddecreased invitamin A, vitamin C and vitamin D in 40 pregnant female and normal in 10 pregnant female. Where, Vitamins levels showedsignificant decreased (P<0.05) 40 pregnant female 10 pregnant femalecompared with 10 normal pregnant female. Also, results show a high correlation between decreased vitamins levels and newborn weights. It was concluded from this study that the vitamins deficiency (A, C and D) in maternal led to decreased the weights of newborn.
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Gray, Brenda. "Vitamin Deficiency." Science News 159, no. 8 (February 24, 2001): 115. http://dx.doi.org/10.2307/3981595.
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Andrade, Isabella Pedrotti Leme de, Taís Donha Yarid Angelieri, Vitória de Oliveira Cristóvão, Luiza Santucci Teixeira, Giovanna Rossetto Magalhães, Carolina Vieira Marum, and João Kleber de Almeida Gentile. "Hypovitaminosis D in post bariatric patients: Narrative review." Brazilian Journal of Case Reports 3, no. 3 (February 20, 2023): 3–7. http://dx.doi.org/10.52600/2763-583x.bjcr.2023.3.3.3-7.
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Obesity can be associated with several diseases, signs, and symptoms. Among them, there is nutrient deficiency, especially vitamin D, which regulates calcium and phosphate and helps in bone remodeling. Vitamin D deficiency is related directly to the inadequate intake of foods rich in vitamins, less exposure to the sun and, mainly, to the sequestration of fat-soluble vitamins by the adipose tissue, making it even more difficult for the body to absorb them. Among these complications is the worsening of vitamin deficiency, with a focus on vitamin D, which is already present before the patient undergoes bariatric surgery. Regarding the types of bariatric surgery, each one establishes a degree of vitamin D deficiency that the patient will have postoperatively. That is, each type of bariatric surgery, as they are performed in different ways, directly interfere with the patient's absorption of vitamins. Postoperatively, vitamin D supplementation is recommended for all patients. However, due to poor patient compliance and lack of consent among physicians on the best form of supplementation, the deficiency is maintained, further impairing the treatment, and causing a worsening of the bariatric patient's condition.
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Koprivica, Marko, Jelena Bjelanovic, and Radmila Velicki. "The effects of vitamin B12 deficiency." Medical review 74, no. 11-12 (2021): 391–95. http://dx.doi.org/10.2298/mpns2112391k.
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Vitamin B12 is one of the most important B vitamins. This vitamin has an important role in cellular metabolism and is also associated with folate and vitamin B6 metabolism. Vitamin B12 deficiency occurs as a result of some diseases, the use of certain medications, or inadequate nutrition. It primarily affects the elderly and women, but is also common among the pediatric population. The B12 deficiency mostly affects the functions of the nervous and hematopoietic systems but it can also affect the skin, heart, bones, and eyes. The treatment of vitamin B12 deficiency includes oral or intramuscular vitamin B12 supplementation according to different treatment regimens.
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Andrès, Emmanuel, Noel Lorenzo-Villalba, Jean-Edouard Terrade, and Manuel Méndez-Bailon. "Fat-Soluble Vitamins A, D, E, and K: Review of the Literature and Points of Interest for the Clinician." Journal of Clinical Medicine 13, no. 13 (June 21, 2024): 3641. http://dx.doi.org/10.3390/jcm13133641.
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Fat-soluble vitamins, including vitamins A, D, E, and K, are energy-free molecules that are essential to the body’s functioning and life. Their intake is almost exclusively exogenous, i.e., dietary. As a result, fat-soluble vitamin deficiencies are rarer in industrialized countries than in countries with limited resources. Certain groups of people are particularly affected, such as newborns or growing children, pregnant or breastfeeding women, and elderly or isolated individuals. Deficiencies in vitamins A, D, E, and K are also relatively frequent in subjects with digestive tract disorders, liver diseases, chronic pathologies, or in intensive care patients. Deficiencies or excesses of fat-soluble vitamins are responsible for a variety of more or less specific clinical pictures. Certain syndromes are typical of fat-soluble vitamin deficiency, such as the combination of ophthalmological and immunity impairments in the case of vitamin A deficiency or hemorrhagic syndrome and osteopenia in the case of vitamin E deficiency. This is also the case for osteomalacia, muscular weakness, even falls, and rickets in the case of vitamin D deficiency. Diagnosis of a deficiency in one of the fat-soluble vitamins relies on blood tests, which are not always essential for routine use. In this context, a therapeutic test may be proposed. Treatment of deficiencies requires vitamin supplementation, a well-balanced diet, and treatment of the cause.
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Inoue, Akitoshi, Kentaro Itabashi, Takayasu Iwai, Hitoshi Kitahara, and Yoshiyuki Watanabe. "Imaging findings of vitamin deficiencies: are they forgotten diseases?" BJR|Open 3, no. 1 (January 2021): 20210011. http://dx.doi.org/10.1259/bjro.20210011.
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Vitamin deficiency is rare in modern industrialised countries; however, it still occurs in patients with specific backgrounds, such as those with extremely unbalanced diets, those with alcoholism and those who have undergone gastrointestinal surgery. Imaging examinations that demonstrate classic findings confirm the clinical diagnosis of vitamin deficiency and help monitor response to treatment. Because vitamin deficiencies are not prevalent, the diagnosis might not be straightforward. Therefore, imaging should be performed in cases of suspected vitamin deficiency. Radiologists should be familiar with characteristic imaging findings of vitamin deficiency and should survey an affected patient’s background and blood vitamin levels. Because symptoms of vitamin deficiency are quickly improved by vitamin replacement, early diagnosis is essential. This pictorial review provides imaging findings for deficiencies in vitamins B1 (Wernicke encephalopathy and wet beriberi), B12 (subacute combined degeneration), C (scurvy), D (rickets) and K (bleeding tendency).
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Koprivica, Marko, and Svetlana Kašiković-Lečić. "Causes, consequences, and treatment of vitamin D deficiency in humans." Medicinski casopis 57, no. 3 (2023): 119–24. http://dx.doi.org/10.5937/mckg57-43860.
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This group of vitamins consists of vitamin D2 and vitamin D3, which are synthesized in the body of some invertebrates and plants, but also in the human body. Ultraviolet rays cause vitamin D to integrate under the skin. The vitamin is transported via specific proteins to all parts of the body, where it performs numerous roles. The low level of vitamin D in blood is a current public health problem. Vitamin D deficiency is especially pronounced among the elderly and obese. Currently, vitamin D deficiency is associated with an increase in bone and cardiovascular diseases, diabetes, malignant, autoimmune and allergies diseases. That is why it is extremely essential to establish and correct the deficiency of this vitamin in a timely manner. Compensation can be done partly through food, but also through oral supplements, and in more severe cases, by intramuscular administration of vitamins.
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Godbole Siddhant Kamble, Bhakti. "Rare Presentation of a Very Common Deficiency (Vitamin B12 Deficiency)." International Journal of Science and Research (IJSR) 12, no. 4 (April 5, 2023): 293–95. http://dx.doi.org/10.21275/sr23404123439.
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Vollbracht, Claudia, Peter W. Gündling, Karin Kraft, and Iris Friesecke. "Blood concentrations of vitamins B1, B6, B12, C and D and folate in palliative care patients: Results of a cross-sectional study." Journal of International Medical Research 47, no. 12 (September 23, 2019): 6192–205. http://dx.doi.org/10.1177/0300060519875370.
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Objective The main purpose of palliative care is symptom relief. Frequently, the symptoms of patients requiring palliative care are the same as common symptoms of vitamin deficiency (e.g. pain, weakness, fatigue, depression). The study aim was to investigate whether patients in palliative care are vitamin deficient. Method This was a monocentre cross-sectional study. Patients attending the palliative care unit of a general hospital in Germany from October 2015 to April 2016 were examined for vitamin blood concentrations and symptoms. Data were analysed using univariate analysis and bivariate correlations. Results Data were available from 31 patients. Vitamin D3 deficiency (<62.5 nmol/L) affected 93.5% of patients, vitamin B6 deficiency (<4.1 ng/mL) 48.4%, vitamin C deficiency (<4.5 mg/L) 45.2%, vitamin B1 deficiency (<35 µg/L) 25.8% and vitamin B12 deficiency (<193 pg/mL) 12.9%. There was a significant negative correlation between vitamin B1 ranges and pain (r = −0.384) and depression (r = −0.439) symptoms. Conclusion All patients showed a deficiency in at least one of the measured vitamins; 68% had concurrent deficiencies in >1 vitamin. A follow-up study using validated questionnaires and a larger sample is needed to investigate the effects of targeted vitamin supplementation on quality of life and symptom burden.
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S., Balasubramanian, Jayakumar M., Lakshmi Narasimhan R., Bhanu K., and Shanmuga Sundaram N. "Neurological Manifestations of Vitamin B12 Deficiency." International Journal of Neurology and Neurosurgery 11, no. 1 (2019): 18–23. http://dx.doi.org/10.21088/ijnns.0975.0223.11119.3.
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Pupić-Bakrač, Ana, Antea Pervan, Jure Pupić-Bakrač, and Jakov Končurat. "Extremely severe vitamin B12 deficiency." Medicina Fluminensis 55, no. 3 (September 1, 2019): 301–10. http://dx.doi.org/10.21860/medflum2019_221625.
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Aim: Vitamin B12 (cobalamin) is nutrient from the vitamin B complex family. It is essential in the human body for deoxyribonucleic acid (DNA) synthesis and for cellular energy production. Vitamine B12 deficiency is decrease in its serum concentration below 220 pmol/L, and it can be present in various range of hematologic and systemic symptoms and signs. The aim of this article is to provide extensive information on extreme forms of deficiency of vitamin B12. Case report: 83-year-old men presented with fatigue, intolerance of physical activity, vertigo, paresthesia in fingers, dispersion, epigastric pain, vomitting and loss of apetite. Vital parameters were within normal range, and physical examination did not reveal any patological findings, except icterus of sclera and subicterus of skin. Urgent laboratory findings showed erythrocytes 1.18 x 1012/L (4.34-5.72 x 1012/L), hemoglobin 50 g/L (138-175 g/L), mean corpuscular volume (MCV) 123.6 fL (83.0-97.2 fL), vitamin B12 < 61 pmol/L (220-665 pmol/L). Patient started parenteral therapy with vitamin B12. After 5 days, rapid increase in reticulocyte count was observed, with haemogram stabilization within 6 weeks. In a follow-up period of two years, the patient had no symptoms. Conclusion: We presented patient with extreme deficiency of vitamin B12. Screening for vitamin B12 deficiency should be established in each patient with macrocytic anemia, even with slightly elevated MCV.
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Malik, Arif, Bushra Shaheen, Muhammad Shahzad Farooq, Qura-Tul Ain, and Sulayman Waquar. "VITAMIN-D DEFICIENCY;." Professional Medical Journal 24, no. 09 (September 8, 2017): 1437–43. http://dx.doi.org/10.29309/tpmj/2017.24.09.947.
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Background: Deficiency of vitamin D is characterized by the low bone masswhich leads to the bone fragility and high risk of fractures. Bone fractures causes the formationof free radicals, generated by the tissue damaged. Uncontrolled production of free radicalsaccelerates the oxidative stress and increased the bone remodeling process ultimatelycauses osteoporosis. One of the most damaging effects of free radicals is lipid peroxidation;end product of which is MDA, it also act as major factor in osteoblastic activity. Low level ofantioxidative defense system found in osteoporotic patients due to the deficiency of vitamin D.Many important mineral ions removed from bones and risk of bone fragility increases. Currentstudy is aim to check the antioxidative effect produced from excess reactive oxygen speciescompared with low level of vitamin D which is held responsible for higher or lower activityof bone cells. Study Design: Case Control Study. Setting: Study was conducted at Instituteof Molecular Biology and Biotechnology (IMBB), University of Lahore. Period of Study: Oneyear. Materials and Methods: Blood samples of 272 post-menopausal osteoporotic womenbetween the age 49-57 were collected from Jinnah hospital Lahore. While the samples of 92individuals were served as a control. Concentration of both enzymatic and non-enzymaticantioxidant such as CAT, GSH, SOD, GPx and GR, vitamin A, C and E and levels of MDAwere estimated spectrophotometrically. While the concentration of IL6, AOPPS, AGEs, TNF-α,MMP9, Isoprostanes, LDH, cholesterol, triglycerides, free fatty acids and phospholipid weremeasured by using commercially available Elisa kits. Results: Blood plasma levels of vitaminD were significantly lower in osteoporosis patients than in normal subjects. In addition, levelof stress biomarker such as MDA was found to be higher in patients as compared to control.Due to oxidative stress, level of antioxidants (GSH, CAT, and SOD) was found to be reduced.Blood cells and many other important minerals are also reduces in patient group from theirnormal amount. Conclusion: It concludes that excess production of free radicals over whelmsthe antioxidative system, thus it may leads to osteoporosis. Further more antioxidant speciessubjected to body might protect bone loss and also help in acceleration of healing of fracturedbones.
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Sharafetdinov, Khaider Kh, Vera M. Kodentsova, Oksana A. Vrzhesinskaya, Olga V. Kosheleva, Nina A. Beketova, Svetlana N. Leonenko, Oxana A. Plotnikova, et al. "Vitamin status of patients with certain chronic non-communicable diseases." Clinical nutrition and metabolism 1, no. 3 (September 15, 2020): 105–16. http://dx.doi.org/10.17816/clinutr50303.
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Background. Inadequate supply with vitamins is a risk factor for the development of many nutritionally-related diseases and their progression. Data on the actual vitamin status of patients are necessary to develop measures for its improvement.
Aim. To characterize the supply of persons with non-communicable diseases with vitamins A, E, C, B2 and -carotene by determining their level in the blood of patients.
Material and methods. The blood serum level of vitamins C, A, E, B2 and -carotene in 138 patients (41 men and 97 women) 2280 years old with cardiovascular diseases, obesity, gastrointestinal diseases, type 2 diabetes mellitus (T2DM), osteoarthrosis has been determined.
Results. Vitamin C concentration corresponded to adequate status in approximately 2/3 of the examined patients; among patients with T2DM, such sufficiency occurred 1.61.9 fold less often than in other groups. The frequency of reduced levels of vitamins C, A and E was statistically significantly more frequent in patients with gastrointestinal diseases. The -/-tocopherol ratio in the serum of patients in all groups was close to 1:50, while in patients with gastrointestinal diseases reached 1:60.7. The proportion of patients sufficiently supplied with all studied vitamins ranged from 15.8 to 70.0%. Patients with osteoarthrosis were best of all provided with all vitamins: multiple (3 or more vitamins) vitamin deficiency was not found. In other groups of patients, multiple vitamin deficiency occurred in 5.327.6% of the examined (an average of 16.4%). Among patients with gastrointestinal diseases there was not a single person sufficiently provided with all the studied vitamins. Multiple vitamin deficiency in patients with gastrointestinal diseases was detected more often (p 0.01) compared with patients with T2DM and osteoarthrosis. Given the high prevalence of vitamin D deficiency, it is possible to extrapolate that a significant proportion of patients with a combined deficiency of 2 vitamins (6.931.6% in the samples examined) will move into the category of persons with a simultaneous deficiency of 3 vitamins.
Conclusion. The purposeful development of supplements containing effective doses of vitamins for various nosologies is necessary.
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Mantle, David. "Nutritional supplementation for vitamin B12 and vitamin K2 deficiency following ileostomy or colostomy formation." Gastrointestinal Nursing 18, Sup4 (May 1, 2020): S12—S16. http://dx.doi.org/10.12968/gasn.2020.18.sup4.s12.
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Most dietary vitamins and minerals are absorbed from the duodenal and jejunal sections of the small bowel. The exceptions are vitamin B12 and vitamin K2, which are absorbed from the terminal ileum and colon respectively. Patients who have undergone ileostomy or colostomy procedures are at risk of deficiency of these vitamins, with associated risk of developing anaemia and nervous system dysfunction (vitamin B12), and bone weakening and cardiovascular disease (vitamin K2). Patients should therefore be monitored for deficiency of these vitamins, which may develop over a protracted period of time. Patients lacking the terminal ileum or colon can still absorb supplemental vitamins B12 or K2 given orally, provided a sufficient loading dose is given to facilitate absorption from the remaining gastrointestinal tract.
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Csapó, J., Cs Albert, and J. Prokisch. "The role of vitamins in the diet of the elderly II. Water-soluble vitamins." Acta Universitatis Sapientiae, Alimentaria 10, no. 1 (October 1, 2017): 146–66. http://dx.doi.org/10.1515/ausal-2017-0010.
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AbstractFollowing a presentation of humans’ water-soluble vitamin requirements, the authors will discuss in detail the role these vitamins play in human organism and outline those major biochemical processes that are negatively affected in the body in case of vitamin deficiency. They point out that in the elderly population of developed countries cases of water-soluble vitamin deficiency are extremely rare and they are due to the lack of dietary vitamin, but mostly to the vitamin being released from its bindings, the difficulty of free vitamin absorption, gastrointestinal problems, medication, and often alcoholism. Among water-soluble vitamins, B12is the only one with a sufficient storage level in the body, capable of preventing deficiency symptoms for a long period of time in cases of vitamin-deficient nutrition. Each type of vitamin is dealt with separately in discussing the beneficial outcomes of their overconsumption regarding health, while the authors of the article also present cases with contradictory results. Daily requirements are set forth for every water-soluble vitamin and information is provided on the types of nutrients that help us to the water-soluble vitamins essential for the organism.
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Sutanto, Luciana B. "The needs of vitamin in medical ill patients." World Nutrition Journal 6, S1 (October 31, 2022): 12. http://dx.doi.org/10.25220/wnj.v06.s1.0008.
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Vitamin deficiency is often appeared in medical ill patients. The vitamin deficiency can be deficiency favouring disease development, inadequacy or deficit worsening the condition, or deficiency as a result of disease. Recommendation number 1 from ESPEN micronutrient guideline 2022 is adequate amounts of all essential trace elements and vitamins shall be supplied to all patients receiving medical nutrition from the beginning of the period of nutritional support.
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Tiangga, Eleanor, Asha Gowda, and John A. Dent. "Vitamin D deficiency in psychiatric in-patients and treatment with daily supplements of calcium and ergocalciferol." Psychiatric Bulletin 32, no. 10 (October 2008): 390–93. http://dx.doi.org/10.1192/pb.bp.107.019109.
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Aims and MethodThis study examines the prevalence of vitamin D deficiency in a group of male psychiatric in-patients and follows 16 of them prospectively during treatment with calcium and ergocalciferol tablets.ResultsOf 17 male patients, 15 had vitamin D deficiency and two had borderline deficiency. Vitamin D deficiency was associated with Black and minority ethnic background. Improvement in vitamin D status was observed following replacement therapy.Clinical ImplicationsVitamin D deficiency may be widespread in the psychiatric population particularly in Black and minority ethnic but also in White European in-patients. Vitamin D level should be routinely monitored in psychiatric in-patients. for those with vitamin D deficiency, replacement therapy can be commenced with calcium and ergocalciferol tablets (containing 10 μg of ergocalciferol), which is safe and well tolerated. All psychiatric in-patients should have adequate exposure to sunlight and attention to diet to ensure that they receive their recommended daily allowance of vitamins and minerals.
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Mihniova, Nataliia. "The Relevance of Correction of Vitamin-mineral Deficiencies in Adults and Children." Family Medicine, no. 4 (December 30, 2016): 55–59. http://dx.doi.org/10.30841/2307-5112.4.2016.248520.
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Nutrient deficiency in the diet increases the risk of various diseases. The article discusses the physiological role of vitamins and minerals, especially vitamin1mineral metabolism in the human body, the main causes of their deficiency in the diet. Recommendations for the prevention and correction of vitamin and mineral deficiencies using customized vitamin and vitamin-mineral complexes.
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Roodenburg, AnnetJ C., Clive E. West, Robert Hovenierl, and Anton C. Beynen. "Supplemental vitamin A enhances the recovery from iron deficiency in rats with chronic vitamin A deficiency." British Journal of Nutrition 75, no. 4 (April 1996): 623–36. http://dx.doi.org/10.1079/bjn19960165.
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Studies with anaemic children and pregnant women from areas where vitamin A deficiency is endemic have shown a beneficial effect on Fe status of supplemental vitamin A in addition to Fe supplementation. This suggests a relationship between vitamin Aand Fe status, which we attempted to mimic in rats with anaemia and chronic vitaminA deficiency. Male rats were fed on Fe-adequate diets (35 mg Fe/kg)containing different levels of vitamin A (1200,450,150,75 and 0 retinol equivalents (RE)/kg feed) until they were 5 weeks old. These diets wereidentical to the diets fed to their mothers. Then the young male rats were transferred to diets containing the same levels of vitamin A but no added Fe. After another 2 weeks the rats wererepleted with Fe (35 mg/kg feed) without or with vitamin A to a level of 1200 RE/kg feed. Increased vitamin A intake by the groups previously fed on diets with either 0 or 75 RE/kg produced a reduction in blood haemoglobin concentration, packed cell volume and erythrocyte count. In the group which had been fed on the diet without vitamin A, supplemental vitamin A raised mean cell volume, plasma Fe concentration and total Fe-binding capacity. Vitamin A supplementation during the period of Fe repletion produceda decrease in splenic and tibia Fe concentration, the effect being greater with increasing seventy of previous vitamin A deficiency. The paradoxical effect of supplemental vitamin A on haemoglobin, packed cell volume and erythrocyte count can be explained by a decrease in the degree of haemwoncentration. Thus, the positive effect of supplemental vitamin A seen in humans is also observed with rats under controlled experimental conditions. We speculate that supplemental vitamin A during Fe repletion contributes to optimum erythropoiesis and Fe mobilization when baseline vitamin A status is impaired
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Ibrahim, Mohammad, Shabina Khan, Sanchita Pathak, Mohd Mazhar, and Harpreet Singh. "Vitamin B-Complex and its Relationship with the Health of Vegetarian People." Natural Resources for Human Health 3, no. 3 (August 23, 2023): 342–54. http://dx.doi.org/10.53365/nrfhh/169824.
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Vitamins are essential for a healthy life. Compared to other nutrients, the body needs them in very small amounts. B vitamins, often known as the vitamin B complex, are a class of water-soluble vitamins with key functions in cellular metabolism. Thiamine (vitamin B1), riboflavin (vitamin B2), niacin (vitamin B3), pantothenic acid (vitamin B5), pyridoxine (vitamin B6), biotin (vitamin B7), folate (vitamin B9), often known as folic acid, and cobalamin (vitamin B12) are the eight distinct vitamins that collectively constitute the vitamin B complex. The body's energy levels, cognitive activity, and cell metabolism are all directly impacted by B vitamins. Four main factors contribute to vitamin B deficiency: an unbalanced diet, excessive alcohol intake, different drugs, and disorders that induce gut malabsorption. If these B vitamin deficiencies are left untreated, they can eventually cause symptoms such as peripheral neuropathy, heart attacks, strokes etc. B vitamins are present in natural, whole foods. Compared to their unprocessed counterparts, white flour and other processed carbohydrates like sugar often contain fewer B vitamins. Excellent sources of vitamins Bs comprise legumes (beans or pulses), potatoes, bananas, whole grains, tempeh, chilli peppers, brewer's yeast, nutritional yeast, and molasses. This paper provides an in-depth summary of the most popular types of vitamin B, emphasizing why the body needs them, the symptoms of a deficiency, and what diet or foods are rich in them.
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Babazadeh, Daryoush, Seyed Amin Razavi, Wafaa A. Abd El-Ghany, and Paul F Cotter. "Vitamin D Deficiency in Farm Animals: A Review." Farm Animal Health and Nutrition 1, no. 1 (September 25, 2022): 10–16. http://dx.doi.org/10.58803/fahn.v1i1.7.
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One of the most effective vitamins in the musculoskeletal structure and immune system of farm animals is Vitamin D. The widespread risk of Vitamin D deficiency states is known widely resulting in autoimmune diseases, diabetes, rickets, metabolic bone diseases, and cancers. The aim of this review is to address the subject of Vitamin D deficiency in farm animals and the role of vitamin D in health and deficiency states. Although Vitamin D deficiency is generally defined as < 20 ng/mL in serum, but this level remains to be discussed. Vitamin D synthesis in the skin is the major source of Vitamin D in the body and is influenced by genetic and several environmental factors, such as length of sun exposure, season, and latitude. Sun exposure might be limited during winter in some areas, such as northern latitudes. Thus, food sources can play essential roles in supplying the demand for vitamin D. Some animal species have more sensitivity to Vitamin D deficiency due to their different metabolism, homeostasis, and adaptation to specific diets and environments. Farm animal species, such as cattle, pigs, llamas, Alpacas, small ruminants, and broiler chickens are more sensitive to Vitamin D deficiency. However, some farm animal species including horses and donkeys usually have a low risk of Vitamin D deficiency. Therefore, the management of Vitamin D deficiency and its consequences are critical in some species. The inclusion of Vitamin D in the body of farm animals depended on farming practices, sun exposure in different seasons, and the content of diets. Due to the diversity of species, regulation of many ongoing processes in animals’ bodies, the complexity of Vitamin D metabolism, and different metabolites, more studies are necessary to find the vital roles of vitamin D in the prevention and control of diseases in farm animals.
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GÜLER, Sertaç Ata, Alican GÜREŞİN, Umut ONBAŞILAR, Turgay ŞİMŞEK, Handan KAYA ÇELİK, Nihat Zafer UTKAN, and Zafer CANTÜRK. "Vitamin and Micronutrient Deficiency and Peripheral Polyneuropathy Following Intragastric Balloon Technique Used For Obese People: Preliminary Study." Turkish Journal of Diabetes and Obesity 6, no. 3 (December 29, 2022): 208–14. http://dx.doi.org/10.25048/tudod.1142865.
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Aim: Complications from malnourishment when treating obesity are common, especially following bariatric surgery. Peripheral polyneuropathy due to vitamin and micronutrient deficiency is the most commonly encountered complication of bariatric surgery. The objective of this study was to investigate if this technique may lead to peripheral polyneuropathy due to vitamin B1, B2, B6, B12,folate, zinc, iron, and copper deficiency.
Material and Methods: In this study nine patients whose obesity was treated with the Spatz3 intragastric balloon technique wereinvestigated for vitamin and micronutrient deficiencies and any consequent peripheral polyneuropathy. Vitamin B1, B2, B6, B12,zinc, copper, iron and folate were measured. Electromyography (EMG) was used to evaluate peripheral polyneuropathy, based on the Toronto Clinical Neuropathy Score (TCNS).
Results: None of the patients had vitamin B1, B2 or B6 deficiency, whereas one patient (11%) had vitamin B12 and another one patient (11%) had folate deficiency. Copper deficiency was seen in five patients (55.6%), iron deficiency was seen in seven patients (77.8%) and zinc deficiency was seen in eight patients (88.9%). Two patients (22.2%) had abnormal sensory nevre velocity and were diagnosed with polyneuropathy. However, these two had normal concentrations of B vitamins and folate but were deficient for copper, iron, and zinc.
Conclusion: The intragastric balloon technique does not appear to be associated with peripheral polyneuropathy due to vitamin B deficiency. In our opinion it is a safe approach for obesity treatment in terms of the risk of peripheral polyneuropathy due to vitamin B deficiency.
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Vilms, E. A., D. V. Turchaninov, T. A. Yunatskaya, and I. A. Sokhoshko. "ASSESSMENT OF VITAMIN PROVISION OF THE POPULATION OF THE LARGE ADMINISTRATIVE AND ECONOMIC CENTER OF THE WESTERN SIBERIA." Hygiene and sanitation 96, no. 3 (March 27, 2019): 277–80. http://dx.doi.org/10.18821/0016-9900-2017-96-3-277-280.
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Evaluation of vitamin status in residents of the Omsk city (106 men and 135 women) aged of from 18 to 75 years according to the serum content of vitamins A, D, E, K, C, B1, B5, B6, B9, B12. Lack of vitamins in the majority of the observed cases (63.2 ± 3.8%) had a combined character. There was revealed pronounce lack of vitamin D and folic acid, respectively in 70.9 ± 3.6% and 63.2 ± 5.6% of observed persons. The substantial proportion of the population was found to suffer from lacks of vitamin B1 (47.5 ± 4.2%), B6 (49.7 ± 3.8%), and vitamin E (47.1 ± 4.0%). The frequency of detection of a reduced availability of vitamin C was 16.2 ± 3.4%, B12 - 13.2 ± 3.2%, respectively. The deficiency of vitamin A deficiency was seldom (from 5.8 ± 1.9%). In the sample no person with a deficiency of vitamin K and pantothenic acid (B5) was revealed. Mediane of concentrations of phylloquinone, retinol and ascorbic acid and cyanocobalamin in blood serum were in the range of optimum values. Borderline values of the content (at the level of the lower limit of normal) were seen for vitamin E, B1, B6. There were found age differences in the availability of vitamins E, K, ascorbic acid.
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Keita, Y., A. A. Ndongo, M. N. Sylla, A. Sylla, B. Niang, D. I. Ly, A. Thiongane, F. Ly, and A. Ba. "Vitamin B12 Deficiency in Children Due to Lack of Intake: A Report of Two Cases at the Pediatric Department at Aristide Le Dantec Hospital." Journal of Pediatric Health and Nutrition 1, no. 3 (October 26, 2021): 3–9. http://dx.doi.org/10.14302/issn.2691-5014.jphn-21-3923.
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We report 2 cases of vitamin B12 deficiency in children due to deficient intake. These were 2 girls aged 4 years (case 1) and 6 years (case 2), respectively, hospitalized in December 2020 and March 2021 in the pediatric ward of Le Dantec hospital. Both patients presented with aregenative anemia, melanoderma and undernutrition. The bone marrow count in case 1 showed a dysmyelopoiesis with megablastosis. The blood vitamin B12 level was low in both cases. Folic acid blood levels were normal in both patients, but an associated martial deficiency was found in case 2. The dietary survey revealed a lack of intake of animal products rich in vitamin B12. Vitamin B12 replacement therapy was effective with rapid regression of all clinical signs observed in both children. The control of the vitamin B12 level after 1 month of treatment was normal in both patients. The disappearance of the symptoms under substitute treatment confirmed the deficiency of Vitamin B12 intake in both patients. Conclusion: Both of our patients had a profound Vitamin B12 deficiency in a context of deficiency in nutrition. The regression of the symptoms was spectacular under vitamin B12 replacement therapy, confirming the deficiency. We recommend in our context a contribution in micronutrients such as vitamins in children after weaning to avoid dietary errors.
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Oh, Jongwon, Hyung-Doo Park, Su-Young Kim, Won-Jung Koh, and Soo-Youn Lee. "Assessment of Vitamin Status in Patients with Nontuberculous Mycobacterial Pulmonary Disease: Potential Role of Vitamin A as a Risk Factor." Nutrients 11, no. 2 (February 5, 2019): 343. http://dx.doi.org/10.3390/nu11020343.
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As microbiological diagnostic techniques improve and the frequency of nontuberculous mycobacterial pulmonary disease (NTM-PD) infection increases worldwide, NTM-PD is becoming increasingly important to clinicians and researchers. Vitamin activity has been associated with the host immune response in tuberculosis; however, such information is very limited in NTM-PD. We performed a case-control study in 150 patients with NTM-PD and 150 healthy controls to investigate serum vitamin status. We measured concentrations of vitamins A, D, and E along with homocysteine and methylmalonic acid (MMA) as indicators of vitamin B12 deficiency, using high-performance liquid chromatography (HPLC) or HPLC-tandem mass spectrometry. The serum concentrations of vitamins A and E were significantly lower in patients with NTM-PD than in healthy controls (1.5 vs. 2.1 µmol/L, p < 0.01 for vitamin A; and 27.3 vs. 33.1 µmol/L, p < 0.01 for vitamin E). In contrast, the serum concentrations of vitamin D and homocysteine were not significantly different between the two groups. Vitamin A deficiency (< 1.05 µmol/L) was significantly more prevalent in patients with NTM-PD than in healthy controls (p < 0.01) and was associated with an 11-fold increase in risk of NTM-PD. Multiple vitamin deficiencies were only observed in patients with NTM-PD (7.3% of all NTM-PD patients). Positive correlations were observed among vitamins (vitamins A and D; r = 0.200, p < 0.05; vitamins D and E, r = 0.238, p < 0.05; vitamins A and E, r = 0.352, p < 0.05). Serum vitamin status, demographic variables, and biochemical indicators were not associated with treatment outcomes. Vitamin A deficiency was strongly associated with patients with NTM-PD. Our study suggests that altered vitamin status is associated with mycobacterial disease. Future well-designed prospective studies with large patient cohorts addressing these issues are needed to clarify the significance of vitamins in NTM-PD.
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Tsukanov, A. Yu, D. V. Turchaninov, D. A. Satybaldin, T. A. Yunatskaya, and K. N. Sokolov. "Micronutrient deficiency in men with infertility." Andrology and Genital Surgery 21, no. 2 (July 5, 2020): 58–63. http://dx.doi.org/10.17650/2070-9781-2020-21-2-58-63.
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The study objective is to compare the level of micronutrients in men with infertility and men with normal fertility. Materials and methods. The levels of А, В9, D, Е, С vitamins in blood using high-performance liquid chromatography and selenium and zinc in hair using atomic absorption mass-spectrometry were measured in men with diagnosis of male idiopathic infertility (n = 82) and men with normal fertility (n = 93).Conclusion. Absence of a total lack of micronutrient deficiency in men with infertility was observed. Presumably, azoospermia can be associated with deficiency in some micronutrients casting doubt on the necessity of administration of multicomponent vitamin and mineral complexes.Results. Blood levels of А, D and В9 vitamins did not significantly differ in the studied groups, while differences in blood levels of С and Е vitamins and selenium and zinc in hair were statistically significant. While the levels of А, Е, В9 vitamins, selenium and zinc were in the reference ranges, vitamin C deficiency was observed in the test group and vitamin D deficiency in both groups. Higher level of selenium in the test group presumably reflects its higher metabolism due to higher influx of xenobiotics in the organism and indicates pre-deficiency state.
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Yadav, Roopesh Kumar, Sudhanshu Mishra, and Deepti Jain. "Methylcobalamine (Vitamin B12): Water Soluble Vitamin with Various Pharmacological Aspect." Journal of Drug Delivery and Therapeutics 11, no. 1 (January 15, 2021): 130–37. http://dx.doi.org/10.22270/jddt.v11i1.4488.
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Vitamin B12 is a water-soluble vitamin that plays a key role in the brain's proper functioning and nervous system, in blood flow, and in reducing weakness and tiredness. In their food, most people get adequate vitamin B12, but in some health conditions (e.g. inadequate sleep, stomach/intestinal disorders, inflammation, cancer), there could be a shortage. If left unchecked, severe Vitamin B12 deficiency results in anemia and nerve damage. Vitamin B12 deficiency is typically treated using parenteral and oral dosage formulations, but absorption and compliance problems are involved with these routes of administration. Most significantly, the function of this missing intrinsic factor has been shown to assist in vitamin B12 absorption and a deficiency known as pernicious anaemia. Vitamin B12 is only partially absorbed when delivered by mouth to patients with pernicious anemia, but hematologically re-absorbed in patients with pernicious anemia. Parenteral administration of the extrinsic element will treat pernicious anaemia satisfactorily. There are several roles and advantages of vitamin B 12 in the human body with therapeutic effects also.
Keywords: Water Soluble Vitamins, Methylcobalamine, Vitamin B12, Pernicious Anaemia.
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ASLAM, MUHAMMAD, ZAHID MASOOD, Abdul SATTAR, and Maria Qudsia. "VITAMIN D DEFICIENCY;." Professional Medical Journal 19, no. 02 (February 22, 2012): 208–13. http://dx.doi.org/10.29309/tpmj/2012.19.02.2013.
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Objective: To study the Prevalence of Vitamin D deficiency in pregnant women. Study Design: A Cross-sectional analyticalstudy through convenient sampling technique. Setting and duration: At a private Clinic located at East Canal Road Faisalabad, from March2011 to June 2011. Material and method: The study included consecutive 61 pregnant women of reproductive age and non-pregnant womenwere excluded. Blood samples were taken in morning i.e. overnight fasting samples, by venepuncture by disposable syringes sample weretaken and samples were stored at -20 degree centigrade till they were analyzed. Our interest was in age and serum Vitamin D 3 levels. Results:Out of 61 pregnant women results showed that 87.0% pregnant women were having Vitamin D deficiency, 10.0% were having Vitamin Dinsufficiency, 3.0% had Vitamin D sufficiency and none shows Vitamin D intoxication. Vitamin D deficiency was more prevalent in pregnantwomen of younger age group. Furthermore prevalence was higher among the pregnant mothers with high parity. Moreover, 65% women werenot exposed to sunlight properly, 60% women had muscle cramps and bony aches. 90% women never were tested for tested Vitamin D levelsbefore. Conclusions: Prevalence of Vitamin D deficiency is significant in pregnant women. It is also important for its effects on various organsand systems of body as well as on pregnancy and neonate. The different aspects of study led to conclusion to emphasize that Health educationbe imparted to pregnant women and their families in terms of diet, proper sunlight exposure and taking Vitamin D supplements in pregnancy. It isthus recommended to perform Vitamin D levels in every pregnant woman.
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Hafiza, Urwa, Waheed Ahmad, Naz Hina, Akhtar M. Shoaib, Khan M. Saleem, and Wajid Muhammad. "Association of vitamin deficiency with the progression of anaemia." Egyptian Journal of Haematology 49, no. 2 (April 2024): 115–20. http://dx.doi.org/10.4103/ejh.ejh_80_23.
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Vitamins are micronutrients that play a vital role in the body’s proper functioning and development. Furthermore, they are an essential requirement of the body for producing red blood cells (RBCs) and their growth. A particular quantity of micronutrients is mandatory for the regulation of body metabolism. Deficiency in vitamins leads to different types of anaemia in the body. Furthermore, deficiencies in both fat-soluble and water-soluble vitamins are linked to the destruction of RBCs. This review article was aimed at finding the correlation between the deficiency of vitamins and anaemia, with a major focus on the deficiency of vitamins B-9 and B-12 and their association with anaemia. In our deep observation of the literature, we found that the deficiency of vitamins causes iron malabsorption, haemoglobin (Hb) synthesis malfunctioning, impaired DNA synthesis, and a disturbed methylation cycle, while a disrupted erythropoiesis process and a reduction in the RBC’s production leads to anaemia. Interference in vitamin B-9 and vitamin B-12-associated chemical reactions causes deficiency and results in diminished DNA synthesis. Malabsorption of vitamins B-9 and B-12 is a major concern for anaemia, but other water and fat-soluble vitamins disrupt iron metabolism and interrupt the erythropoiesis process, which ultimately causes anaemia. There should be a balanced number of vitamins in the diet; otherwise, this will inhibit the production of RBCs. As Vitamin B-9 and B-12 deficiencies have been associated with a reduction in DNA synthesis, further study is required to discover how additional fat-soluble and water-soluble vitamins affect DNA synthesis.
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Gharaibeh, Ahmad. "Relation between vitamin D deficiency and osteoarthritis." Journal of Orthopaedics & Bone Disorders 4, no. 1 (2020): 1–4. http://dx.doi.org/10.23880/jobd-16000194.
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Purpose of the Work: The main objective of our work is to determine the relationship between osteoarthritis and deficiency of vitamin D in our region in central Europe and to make a database for further researches, to be effective in investigating, controlling, and preventing OA and vitamin D deficiency in our population. Methodology: We perform a retrospective study in adult patients≥25years with osteoarthritis big joints from their health records, which were seen at the osteology clinic of University Hospital Louise Pasteur during the year 2018. The authors analyse the blood tests of Vitamin D level, calcium level, phosphorus level, B ALP, glomerular filtration rate (GFR) levels in the serum of these patients. Results: There were 47 patients with osteoarthritis. All of these patients had Vitamin D deficiency. The mean age of our group is 71 years. 12.8% (7) are male and 87.2% (41)are female. The mean of vitamin D is 24mmol/l (normal range 75-200 nmol/l), Calcium level with in normal range, Phosphorus level mean was within normal range and B ALP level within normal. Conclusion: Osteoarthritis increased by deficiency of vitamin D level in blood serum and increasing with age. Vitamin D is a fat-soluble vitamin that regulates calcium and phosphorus metabolism, maintenance of the normal skeletal and muscular systems. Most of the patients show OA in hip and knee and in advanced age 71 years. Vitamin D supplementation may be a safe method to treat and prevent OA.
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Gohil, K., L. Packer, B. de Lumen, G. A. Brooks, and S. E. Terblanche. "Vitamin E deficiency and vitamin C supplements: exercise and mitochondrial oxidation." Journal of Applied Physiology 60, no. 6 (June 1, 1986): 1986–91. http://dx.doi.org/10.1152/jappl.1986.60.6.1986.
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The effects of dietary antioxidant vitamins E and C on exercise endurance capacity and mitochondrial oxidation were investigated in rats. The endurance capacity of both vitamin E-deficient and vitamin C-supplemented, E-deficient rats was significantly (P less than 0.05) lower (38.1 and 33.6%, respectively) than control animals. Compared with the normal and vitamin E-deficient rats, there was a significant (P less than 0.05) increase in the concentration of vitamin C in blood and liver of the vitamin E-deficient, C-supplemented animals. Hence dietary vitamin C supplementation does not prevent the inhibition of exercise endurance capacity or increased hemolysis seen in vitamin E deficiency. The mitochondrial activities for the oxidation of palmitoyl carnitine and alpha-ketoglutarate were significantly (P less than 0.05) decreased by a single bout of exercise in brown adipose tissue but not in muscle, heart, or liver from vitamin C-supplemented, E-deficient groups of rats when compared with the activities in the tissue from the same group of rats killed at rest. Similar results were also seen in brown adipose tissue from vitamin E-deficient rats. The results suggest a tissue-specific role for vitamins E and C in substrate oxidation and show that the poor endurance capacity of vitamin E-deficient rats cannot be attributed to any changes in the mitochondrial activity in skeletal or cardiac muscles. It is also concluded that vitamin C supplementation, at least at the dose employed in the present study, cannot counteract the detrimental effects associated with vitamin E deficiency.
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Haidrani, Layla. "Vitamin Deficiency Finder." Nursing Standard 30, no. 10 (November 4, 2015): 29. http://dx.doi.org/10.7748/ns.30.10.29.s34.
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ABALLI, ARTURO J. "Vitamin K Deficiency." Pediatrics 75, no. 2 (February 1, 1985): 372–73. http://dx.doi.org/10.1542/peds.75.2.372a.
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To the Editor.— The article by Payne and Hasegawa1 on vitamin K deficiency of the newborn correctly stresses the existence of differences between vitamin K deficiency and Coumadin effect. This has been somewhat forgotten in important studies on the mode of action of prothrombin.2-4 Modern techniques as the Echis time5 and certain sophisticated electrophoretic6 methods confirm the suspected differences between these two disorders. However, many years ago it was shown7-9 that microgram doses of any vitamin K rapidly corrected the coagulation defect in deficiency.
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PAYNE, NATHANIEL R., and DUANE K. HASEGAWA. "Vitamin K Deficiency." Pediatrics 75, no. 2 (February 1, 1985): 373–74. http://dx.doi.org/10.1542/peds.75.2.373.
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In Reply.— We agree with Aballi that a combination of factors placed our patient1 at high risk for vitamin K deficiency during her first month of life. These factors include decreased intestinal absorption of vitamin K due to the cholestatic liver disease of α-1-antitrypsin deficiency and a diet consisting solely of breast milk which is known to have little vitamin K. Aballi correctly points out the lack of data on the role of vitamin K in preventing late-onset hemorrhagic disease.
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Zendjabil, Mustapha, and Omar Abbou. "Vitamin D deficiency." Batna Journal of Medical Sciences (BJMS) 2, no. 2 (December 30, 2012): 153–55. http://dx.doi.org/10.48087/bjmsra.2015.2211.
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La vitamine D a des effets sur l’os qui sont bien connus. Ces dernières années, d’autres effets ont été mis en évidence et les études observationnelles ont noté des associations avec de nombreuses pathologies. Le déficit en cette vitamine est très fréquent. L’évaluation du statut en vitamine D repose sur le dosage de la 25-OHD qui a très récemment fait l’objet d’une standardisation. Alors que l’intérêt de la supplémentation en vitamine D dans le cadre des pathologies osseuses est clairement établi, son intérêt dans le cadre des maladies métaboliques et immunitaires n’est pas encore démontré.
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Lakho, Arshad Sattar, Aqeel Ahmed Channa, Abdul Ghaffar Dars, Syed Zulfiquar Ali Shah, and Muhammad Iqbal. "VITAMIN B12 DEFICIENCY." Professional Medical Journal 25, no. 05 (May 10, 2018): 753–58. http://dx.doi.org/10.29309/tpmj/2018.25.05.321.
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Objectives: To determine the frequency of vitamin B12 deficiency in patientswith hypothyroidism. Study Design: Cross sectional descriptive study. Period: 12-05-2016to 11-11-2016. Setting: Liaquat University Hospital Jamshoro / Hyderabad. Patients andMethods: All the patients of known hypothyroid patients for ≥01month duration, 20-50 yearsof age, either gender were explored for serum vitamin B12 level. The SPSS was used tomanipulate the data in relation to mean ±SD, frequencies and percentages and through chisquaretest to get the p-values and its level of significance (≤0.05). Results: Total 145 patientswith hypothyroidism were evaluated for B12 deficiency, of which 97 (66.8%) were males and48 (33.1%) were females respectively. Ninety patients (62%) were from urban areas while 55(37.9%) was rural population. The mean ±SD for age of overall population was 41.83±8.93years while the mean age ±SD for vitamin B12 deficient and non deficient was 39.96±7.82and 40.74±8.54 years respectively. The vitamin B12 deficiency was observed in one hundredand five patients (72%), of which 69 (65.7%) males and 36 (34.3%) females. The mean ± SDfor duration of infection in overall population was 5.32±1.53 months while it was 5.81±1.43 invitamin B12 deficient individuals. Conclusion: The vitamin B12 deficiency is more pronouncedin hypothyroid patients. In present series vitamin B12 deficiency was observed in 105 (72%)individuals with male predominance 69 (65.7%).
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Hassan, Irfana, Bhagwan Das, Santosh Kumar, Ghulam Haider Khalid, Abdul Manan Junejo, Noor-Un Nisa, and Rahul Kumar. "VITAMIN B12 DEFICIENCY;." Professional Medical Journal 24, no. 06 (June 5, 2017): 878–87. http://dx.doi.org/10.29309/tpmj/2017.24.06.1188.
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Objectives: To determine the frequency of neurological manifestations of vitamin B12deficiency and to observe the reversibility of the symptoms after the therapy. Study Design: Descriptivestudy. Study Design: Descriptive study. Setting: Medicine Department of Bolan Medical Complex HospitalQuetta. Period: One year that is from January 2012 to December 2012. Methodology: 46 patients presentedto various OPDS of B.M.C.H.. The inclusion criteria for the patients to be studied were: Anemia, Neurologicalcomplaints. Results: Out of 46 patients 26(56%) were males and 20(43%) were the females with a meanage of (40) years.32 (69%) belonged to the rural areas. 45(97%) had mixed diets whereas only one 1(2.1%)young non Muslim was found to be pure vegetarian.32 (69%) patients presented with hematological aswell as neurological complaints. 23(30%) had pancytopenia and 9(19.5%) had bicytopenia. 14(30%)presented with neurological complaints only as sacd 6 (13%), ataxia 8 (17%), sensorimotor neuropathies36 (78%) and dementia 2 (4.3%). In signs glossitis was found in 6(13%), jaundice in 22 (47%), pallor in32 (69%) proximal myopathy in 12 (26%) out of which 6 (13%) had shoulder girdle and 8 (17%) pelvicgirdle myopathy. Impaired position sense was found in 18 (39%) patients and vibration sense in 21(45%)patients. other signs were pigmentation 2(4.3%) hypotonia in 6(13%) Spasticity in 2(4.3%) and Upgoingplantars in 6(13%) patients. Lhermittes sign could be elicited in only 2(4.3%) patients Optic neuritis andoptic atrophy was found in 4(8.6%) patients who came with paraplegia and marked anemia. Rhombergssign was positive in 8(17.3%) who came with clumsiness of gait. Hemoglobin (Hb %) was found to be lowin 32(69%) with a mean of 7.2gm%.pancytopenia (anemia+leucopenia+thrombocytopenia) was found in23(50%) of patients whereas bicytopenia was found only in 9(19.5%) of patients. Hypersegmented W.B.Cwere very carefully looked for and were found in 20(43%) of cases. ovalomegaloblasts were found in 32(69%) of cases .both findings of ovalomegaloblasts and hypersegmented w.b.cs were found in 20 (43%).in the rest 14 (30%) the blood investigations were found to be normal. The next investigation in all patientswas serum B12 estimation, It was found that levels below 200pg/ml were found in 95% cases where only2(4.3%) patients came with levels slightly above 205pg/ml and 210pg/ml. the response to therapy wasrecorded as reversible and irreversible. the irreversible features were sacd in 6 (13%), optic atrophy in2 (4.3%), and dementia in 2 (4.3%) patients. the partially reversible features were myelopathy 10 (21%)numbness and paraesthesias 30 (65%) optic neuritis inn 2 (4.3%) patients were assessed on a durationof 24 weeks. partially reversible features were ataxia, in 6 (13%) patients myelopathy in 2 (4.3%) patientsdementia in 2 (4.3%) patients and paraesthesias and numbness in 6 (13%) patients over a period of 24weeks. Conclusion: It is concluded from my study that the neuropsychiatric manifestations of vitamin B12deficiency are common among the elderly age group, either with or with out the evidence of anemia.
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Potrokhova, E. A., N. V. Sobotyuk, S. V. Bochantsev, S. A. Golochalova, E. E. Shlykova, and N. G. Mazhukina. "VITAMIN D DEFICIENCY." Pediatric pharmacology 11, no. 2 (April 4, 2014): 30. http://dx.doi.org/10.15690/pf.v11i2.954.
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Holick, Michael F. "Vitamin D Deficiency." New England Journal of Medicine 357, no. 3 (July 19, 2007): 266–81. http://dx.doi.org/10.1056/nejmra070553.
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Hewett, J. Lluyd. "Vitamin A deficiency." Clinical and Experimental Optometry 77, no. 2 (March 1994): 76–77. http://dx.doi.org/10.1111/j.1444-0938.1994.tb02378.x.
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Clarke, Nicholas M. P., and Jonathan E. Page. "Vitamin D deficiency." Current Opinion in Pediatrics 24, no. 1 (February 2012): 46–49. http://dx.doi.org/10.1097/mop.0b013e32834ec8eb.
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Nash, Samantha. "Vitamin B12 deficiency." British Journal of Midwifery 24, no. 11 (November 2, 2016): 763–64. http://dx.doi.org/10.12968/bjom.2016.24.11.763.
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