Journal articles: 'VIT'

1

Gunnars, Kristjana, and þorsteinn Marelsson. "Meira vit." World Literature Today 69, no. 3 (1995): 600. http://dx.doi.org/10.2307/40151493.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Abusam, A., F. Al-Salameen, A. Mydlarczyk, and M. E. I. Ahmed. "Filamentous Bacteria Identification by VIT Method." International Journal of Environmental Science and Development 7, no. 3 (2016): 177–80. http://dx.doi.org/10.7763/ijesd.2016.v7.763.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Wang, Haiying, and Chuantao Li. "The General (α,3)-Path Connectivity Indices of Polycyclic Aromatic Hydrocarbons." Discrete Dynamics in Nature and Society 2018 (September 5, 2018): 1–5. http://dx.doi.org/10.1155/2018/5702346.

Full text

Abstract:

The general (α,t)-path connectivity index of a molecular graph originates from many practical problems such as three-dimensional quantitative structure-activity (3D QSAR) and molecular chirality. It is defined as Rtα(G)=∑Pt=vi1vi2⋯vit+1⊆G[d(vi1)d(vi2)⋯d(vit+1)]α, where the summation is taken over all possible paths of length t of G and we do not distinguish between the paths vi1vi2⋯vit+1 and vit+1⋯vi2vi1. In this paper, we focus on the structures of Polycyclic Aromatic Hydrocarbons (PAHn), which play a role in organic materials and medical sciences. We try to compute the exact general (α,3)-path connectivity indices of this family of hydrocarbon structures. Furthermore, we exactly derive the monotonicity and the extremal values of R3α(PAHn) for any real number α. These valuable results could produce strong guiding significance to these applied sciences.

APA, Harvard, Vancouver, ISO, and other styles

4

Özsoylu, Şinasi. "Vit B12 treatment." European Journal of Pediatrics 171, no. 4 (December 2, 2011): 737. http://dx.doi.org/10.1007/s00431-011-1637-9.

Full text

APA, Harvard, Vancouver, ISO, and other styles

5

Mouré, Kenneth, and Paula Schwartz. "On vit mal." Food, Culture & Society 10, no. 2 (July 2007): 261–95. http://dx.doi.org/10.2752/155280107x211449.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Hirszfeld, Aleksandra. "#20latfotografi ipwsft vit." Images. The International Journal of European Film, Performing Arts and Audiovisual Communication 13, no. 22 (January 13, 2013): 221. http://dx.doi.org/10.14746/i.2013.22.14.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Kumar, Santosh, Gaffar Memon, Bagwan Das, and Pushpa Mohan. "VIT D DEFICIENCY." Professional Medical Journal 23, no. 09 (September 10, 2016): 1064–67. http://dx.doi.org/10.29309/tpmj/2016.23.09.1697.

Full text

Abstract:

Objectives: To determine the outcome of vitamin deficiency in local populationof (Hyderabad), come with complaints of vague symptoms of body ache, bony pain with noco morbidity. Study design: cross-sectional study. Place and duration of study: OutpatientDepartment of Liquat University Medical Science, Hyderabad. Period: 6-2-2013 to 6-2-2015.Methodology: This is observational cross sectional study conducted at out patient’s department(LUMHS) city Hyderabad from 6-2-13 to 6-2-2015. Preliminary data was collected with the helpof self-administered questionnaires which include patient’s history and examination and bloodsample is taken for assessing level of dehydrocholecalciferol with serum calcium and routinetest. Data entered in spss 20 version, analytical software were applied for results in this study.Result: This study is conducted in 300 pts, among these 60% female and 36.7% male and 3.3%missing. Patients selected through (OPD) with consent and preformed proforma. Vitamin ddeficiency found nearly 96%in all the patient from young age to old age 4% were missing, lessthan 10 level found in 24.7%(severe deficiency), 10-20 level seen 54.7%(moderate deficiency)and 20-30 found in 14.7% (mild deficiency). Conclusion: my results shows that ( vitaminD-deficiency) is big dilemma in our community, give rise mild, moderate and severe decreasedlevel which leads complication which causing rickets in children and osteomalcia in adults,increase mortality and morbidity in local population.

APA, Harvard, Vancouver, ISO, and other styles

8

Mandell, Erica, Gregory Seedorf, Jason Gien, and Steven H. Abman. "Vitamin D treatment improves survival and infant lung structure after intra-amniotic endotoxin exposure in rats: potential role for the prevention of bronchopulmonary dysplasia." American Journal of Physiology-Lung Cellular and Molecular Physiology 306, no. 5 (March 1, 2014): L420—L428. http://dx.doi.org/10.1152/ajplung.00344.2013.

Full text

Abstract:

Vitamin D (vit D) has anti-inflammatory properties and modulates lung growth, but whether vit D can prevent lung injury after exposure to antenatal inflammation is unknown. We hypothesized that early and sustained vit D treatment could improve survival and preserve lung growth in an experimental model of bronchopulmonary dysplasia induced by antenatal exposure to endotoxin (ETX). Fetal rats (E20) were exposed to ETX (10 μg), ETX + Vit D (1 ng/ml), or saline (control) via intra-amniotic (IA) injections and delivered 2 days later. Newborn pups exposed to IA ETX received daily intraperitoneal injections of vit D (1 ng/g) or saline for 14 days. Vit D treatment improved oxygen saturations (78 vs. 87%; P < 0.001) and postnatal survival (84% vs. 57%; P < 0.001) after exposure to IA ETX compared with IA ETX alone. Postnatal vit D treatment improved alveolar and vascular growth at 14 days by 45% and 25%, respectively ( P < 0.05). Vit D increased fetal sheep pulmonary artery endothelial cell (PAEC) growth and tube formation by 64% and 44%, respectively ( P < 0.001), and prevented ETX-induced reductions of PAEC growth and tube formation. Vit D directly increased fetal alveolar type II cell (ATIIC) growth by 26% ( P < 0.001) and enhanced ATIIC growth in the presence of ETX-induced growth suppression by 73% ( P < 0.001). We conclude that antenatal vit D therapy improved oxygenation and survival in newborn rat pups and enhanced late lung structure after exposure to IA ETX in vivo, which may partly be due to direct effects on vascular and alveolar growth.

APA, Harvard, Vancouver, ISO, and other styles

9

Akolkar, Gauri, Ashim K. Bagchi, Prathapan Ayyappan, Davinder S. Jassal, and Pawan K. Singal. "Doxorubicin-induced nitrosative stress is mitigated by vitamin C via the modulation of nitric oxide synthases." American Journal of Physiology-Cell Physiology 312, no. 4 (April 1, 2017): C418—C427. http://dx.doi.org/10.1152/ajpcell.00356.2016.

Full text

Abstract:

An increase in oxidative stress is suggested to be the main cause in Doxorubicin (Dox)–induced cardiotoxicity. However, there is now evidence that activation of inducible nitric oxide synthase (iNOS) and nitrosative stress are also involved. The role of vitamin C (Vit C) in the regulation of nitric oxide synthase (NOS) and reduction of nitrosative stress in Dox-induced cardiotoxicity is unknown. The present study investigated the effects of Vit C in the mitigation of Dox-induced changes in the levels of nitric oxide (NO), NOS activity, protein expression of NOS isoforms, and nitrosative stress as well as cytokines TNF-α and IL-10 in isolated cardiomyocytes. Cardiomyocytes isolated from adult Sprague-Dawley rats were segregated into four groups: 1) control, 2) Vit C (25 µM), 3) Dox (10 µM), and 4) Vit C + Dox. Dox caused a significant increase in the generation of superoxide radical (O2·−), peroxynitrite, and NO, and these effects of Dox were blunted by Vit C. Dox increased the expression of iNOS and altered protein expression as well as activation of endothelial NOS (eNOS). These changes were prevented by Vit C. Dox induced an increase in the ratio of monomeric/dimeric eNOS, promoting the production of O2·−, which was prevented by Vit C by increasing the stability of the dimeric form of eNOS. Vit C protected against the Dox-induced increase in TNFα as well as a reduction in IL-10. These results suggest that Vit C provides cardioprotection by reducing oxidative/nitrosative stress and inflammation via a modulation of Dox-induced increase in the NO levels and NOS activity.

APA, Harvard, Vancouver, ISO, and other styles

10

Zang, Qun S., Hesham Sadek, David L. Maass, Bobbie Martinez, Lisha Ma, Jessica A. Kilgore, Noelle S. Williams, et al. "Specific inhibition of mitochondrial oxidative stress suppresses inflammation and improves cardiac function in a rat pneumonia-related sepsis model." American Journal of Physiology-Heart and Circulatory Physiology 302, no. 9 (May 1, 2012): H1847—H1859. http://dx.doi.org/10.1152/ajpheart.00203.2011.

Full text

Abstract:

Using a mitochondria-targeted vitamin E (Mito-Vit-E) in a rat pneumonia-related sepsis model, we examined the role of mitochondrial reactive oxygen species in sepsis-mediated myocardial inflammation and subsequent cardiac contractile dysfunction. Sepsis was produced in adult male Sprague-Dawley rats via intratracheal injection of S. pneumonia (4 × 106colony formation units per rat). A single dose of Mito-Vit-E, vitamin E, or control vehicle, at 21.5 μmol/kg, was administered 30 min postinoculation. Blood was collected, and heart tissue was harvested at various time points. Mito-Vit-E in vivo distribution was confirmed by mass spectrometry. In cardiac mitochondria, Mito-Vit-E improved total antioxidant capacity and suppressed H2O2generation, whereas vitamin E offered little effect. In cytosol, both antioxidants decreased H2O2levels, but only vitamin E strengthened antioxidant capacity. Mito-Vit-E protected mitochondrial structure and function in the heart during sepsis, demonstrated by reduction in lipid and protein oxidation, preservation of mitochondrial membrane integrity, and recovery of respiratory function. While both Mito-Vit-E and vitamin E suppressed sepsis-induced peripheral and myocardial production of proinflammatory cytokines (tumor necrosis factor-α, interleukin-1β, and interleukin-6), Mito-Vit-E exhibited significantly higher efficacy ( P < 0.05). Stronger anti-inflammatory action of Mito-Vit-E was further shown by its near-complete inhibition of sepsis-induced myeloperoxidase accumulation in myocardium, suggesting its effect on neutrophil infiltration. Echocardiography analysis indicated that Mito-Vit-E ameliorated cardiac contractility of sepsis animals, shown by improved fractional shortening and ejection fraction. Together, our data suggest that targeted scavenging of mitochondrial reactive oxygen species protects mitochondrial function, attenuates tissue-level inflammation, and improves whole organ activities in the heart during sepsis.

APA, Harvard, Vancouver, ISO, and other styles

11

Kim, Tae-Il, Tae-Gyun Kim, Dong-Hyun Lim, Sang-Bum Kim, Seong-Min Park, Tai-Young Hur, Kwang-Seok Ki, Eung-Gi Kwon, Mayakrishnan Vijayakumar, and Young-Jun Kim. "Preparation of Nanoemulsions of Vitamin A and C by Microfluidization: Efficacy on the Expression Pattern of Milk-Specific Proteins in MAC-T Cells." Molecules 24, no. 14 (July 15, 2019): 2566. http://dx.doi.org/10.3390/molecules24142566.

Full text

Abstract:

In this study, we prepared stabilized vitamin A and C nanoemulsions, and investigated their efficacy on milk-specific proteins in bovine mammary epithelial cells (MAC-T). Emulsions of vitamin A (vit-A) and C (vit-C) were prepared using Lipoid S 75 and microfluidization. The particle size and polydispersity index (PDI) of nanoemulsified vit-A and vit-C were studied. The cytotoxic effect of nanoemulsion-free and nanoemulsified vit-A and vit-C was determined by an MTT assay. In addition, the efficacy of nanoemulsified vit-A and vit-C on the in vitro expression pattern of milk-specific proteins in MAC-T cells was investigated by quantitative RT-PCR. The results showed that the efficacies of stabilized nanoemulsions of vit-A and vit-C were 100% and 92.7%, respectively. The particle sizes were around 475.7 and 225.4 nm, and the zeta potentials were around −33.5 and −21.3 mV, respectively. The expression changes of αs2-, β- and κ-casein were higher in the presence of a stabilized nanoemulsion of vit-A, compared with nanoemulsion-free vit-A. Furthermore, the expression changes of αs2- and β-casein were lower and that of κ-casein was higher in the presence of a stabilized nanoemulsion of vit-C, compared with nanoemulsion-free vit-C. Thus, our findings demonstrate the efficacy of nanoemulsified vit-A and vit-C in changing the expression of milk-specific proteins in MAC-T cells.

APA, Harvard, Vancouver, ISO, and other styles

12

Taş, Sibel, Emre Sarandöl, and Melahat Dirican. "Vitamin B6 Supplementation Improves Oxidative Stress and Enhances Serum Paraoxonase/Arylesterase Activities in Streptozotocin-Induced Diabetic Rats." Scientific World Journal 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/351598.

Full text

Abstract:

The purpose of this study was to investigate the effects of vitamin B6 (Vit B6) on oxidant and antioxidant status in streptozotocin-induced diabetic rats. Thirty-two Wistar rats were divided into four groups: control (C), control + Vit B6 group (C + Vit B6), diabetes (D), and diabetes + Vit B6 group (D + Vit B6). Vit B6 (4 mg/kg body weight) was administered in drinking water for 4 weeks after the induction of diabetes. Vitamin B6 reduced serum total cholesterol level in the C + Vit B6 (P< 0.01) and D + Vit B6 (P< 0.05) groups. Plasma and tissue malondialdehyde levels were reduced in the C + Vit B6 and D + Vit B6 groups. Whole blood glutathione peroxidase (GSH-Px) and erythrocyte superoxide dismutase (SOD) activities were higher in the D group (P< 0.05). GSH-Px and SOD activities were increased in C + Vit B6 group while these parameters decreased in the D + Vit B6 group. Paraoxonase and arylesterase activities were decreased in the D group while they were increased in C + Vit B6 and D + Vit B6 groups. The results of present study suggest that vitamin B6 supplementation might be a promising adjunctive agent for improving oxidative stress and metabolic disturbances and for preventing diabetic complications including atherogenesis.

APA, Harvard, Vancouver, ISO, and other styles

13

Ma, Chang-yong, Hoang Trinh-Dinh, Van-Truong Nguyen, Trong-Dat Le, Van-Dung Le, Huu-Oanh Le, Jiang Yang, Zi-Jie Zhang, and Peng-Fei Fan. "Transboundary conservation of the last remaining population of the cao vit gibbon Nomascus nasutus." Oryx 54, no. 6 (September 26, 2019): 776–83. http://dx.doi.org/10.1017/s0030605318001576.

Full text

Abstract:

AbstractThe cao vit gibbon Nomascus nasutus, also known as eastern black crested gibbon, is categorized as Critically Endangered on the IUCN Red List and was considered one of the world's 25 most threatened primates. The only known population occurs along the border between China and Viet Nam. Accurate information on population size and dynamics is critical for the species’ conservation, but population surveys conducted in only one country may over- or underestimate total population size because the home ranges of cao vit gibbon groups often cross the international border. In 2007 and 2016 we conducted two collaborative transboundary censuses of the cao vit gibbon populations in the Trung Khanh Cao Vit Gibbon Species and Habitat Conservation Area in Viet Nam and the Bangliang Gibbon National Nature Reserve in China. The results showed a population size of 102–110 in 2007, which increased to 107–136 in 2016. Our results indicate that previous surveys conducted separately in Viet Nam and China underestimated the global population size of this species. According to our more comprehensive surveys, the gibbon population is increasing slowly. The gibbons and their habitat are legally protected in both countries. Hunting and charcoal making have not been reported in this area since 2007. As habitat carrying capacity is a limiting factor, habitat restoration is required. However, lack of funding to protect the cao vit gibbon remains a challenge.

APA, Harvard, Vancouver, ISO, and other styles

14

Attia, Youssef A., Mohammed A. Al-Harthi, Ali S. El-Shafey, Yassar A. Rehab, and Woo Kyun Kim. "Enhancing Tolerance of Broiler Chickens to Heat Stress by Supplementation with Vitamin E, Vitamin C and/or Probiotics." Annals of Animal Science 17, no. 4 (October 1, 2017): 1155–69. http://dx.doi.org/10.1515/aoas-2017-0012.

Full text

Abstract:

AbstractHeat stress is one of the major challenges which the poultry industry faces during summer in tropical and subtropical regions. This study was conducted to evaluate the impact of Vitamin (Vit) E, C and/or probiotics on improving tolerance of broiler chickens to chronic heat stress (CHS). A total of 294, 1-day-old Cobb-500 broiler chicks were allocated into seven treatment groups; Thermoneutral group was raised under a thermoneutral condition during 25–42 d of age. The other six groups were raised for three successive days per week at 36±2ºC and 75–85% relative humidity for 7 h daily: heat stressed group, Vit E (100 mg/kg diet), Vit C (200 mg/kg diet), Vit C+Vit E, probiotics (Saccharomyces cerevisiae and Lactobacillus acidophilus at 2 g/kg diet) and Vit C+Vit E+probiotics. Exposure to CHS decreased body weight gain (BWG), feed intake (FI), and abdominal fat. It had adverse impact on feed conversion ratio (FCR), packed cell volume (PCV), monocyte, basophil, total protein, and phagocytic activity while increased plasma cholesterol and aspartate aminotransferase (AST) compared to the thermoneutral group. Vit E, Vit C or probiotics alone decreased the adverse effects of CHS on growth rate throughout the experimental period. Vit C and E were equally potent during the experimental period, but were less effective than the combination of both vitamins. Vit E increased the dressing percentage and abdominal fat as compared to the thermoneutral group, but decreased AST while increasing basophil, monocyte and globulin compared to the heat stressed group. In addition, serum albumin and AST of Vit E were lower compared to Vit C, but cholesterol was higher. Vit E increased red blood cells and white blood cells, but plasma cholesterol was increased compared with the heat stressed group. Vit C increased PCV, lymphocytes, monocyte, basophil and albumin and decreased neutrophil. Both vitamins without/with probiotic induced a further increase in basophil, serum total protein, and albumin. It could be concluded that supplementation of Vit E, Vit C, probiotics, and different combinations reduced some of the adverse effects of CHS, and Vit E+Vit C+probiotics was the most effective for economic traits followed by Vit E+Vit C or probiotics.

APA, Harvard, Vancouver, ISO, and other styles

15

Loraux, Nicole. "Ce que vit Tirésias." Revue française de psychanalyse 74, no. 4 (2010): 1141. http://dx.doi.org/10.3917/rfp.744.1141.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Héritier-Augé, Françoise. "Ce que vit Tirésias." Mètis. Anthropologie des mondes grecs anciens 9, no. 1 (1994): 327–34. http://dx.doi.org/10.3406/metis.1994.1034.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Mizuno, Hatsuhiko. "Vit D derivatives, Bisphosphonates." Japanese Journal of Pharmacology 67 (1995): 41. http://dx.doi.org/10.1016/s0021-5198(19)46133-7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Lefrancois, G. "VIT’ ECHO : premiers résultats." Néphrologie & Thérapeutique 13, no. 5 (September 2017): 299. http://dx.doi.org/10.1016/j.nephro.2017.08.009.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Delbès, Christiane, and Joëlle Gaymu. "Qui vit en institution ?" Gérontologie et société 28 / n° 112, no. 1 (2005): 13. http://dx.doi.org/10.3917/gs.112.0013.

Full text

APA, Harvard, Vancouver, ISO, and other styles

20

Marek, Élie, and Elias Boisjean. "Tout ce qui vit." Ballast N° 10, no. 2 (October 21, 2020): 170–77. http://dx.doi.org/10.3917/ball.010.0170.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Lux, Sebastian. "Blutdrucksenker beeinflussen VIT nicht." Allergo Journal 30, no. 6 (September 2021): 8. http://dx.doi.org/10.1007/s15007-021-4886-6.

Full text

APA, Harvard, Vancouver, ISO, and other styles

22

Ebarb, Sara, Kari Saddoris-Clemons, Kathryn Price, James Jolliff, and Sabrina Williams. "188 Effects of an antioxidant support technology and vitamin E on growth performance of naturally health-challenged nursery pigs." Journal of Animal Science 97, Supplement_2 (July 2019): 109. http://dx.doi.org/10.1093/jas/skz122.193.

Full text

Abstract:

Abstract The effects of an antioxidant support technology (AOX, Promote® AOX™; Provimi, Brookville, OH) in diets with different levels of vitamin E (VIT-E) were evaluated. A total of 1,848 naturally health-challenged (determined by ~2% higher than the yearly average barn mortality) pigs (~19 d of age; 5.9 ± 0.4 kg), 14 pens/treatment, and 22 pigs/pen were housed in two barns which were blocked separately by pen location and randomly allocated to treatments. Treatments were arranged as a 2 × 3 factorial with three levels of AOX (0, 0.02, 0.13%) and two levels of VIT-E (35 or 100 IU/kg). Pen weights were obtained on d 0, 7, 21, and 40 post-weaning. Growth performance and mortalities and removals were evaluated. Constructed contrasts were: 0 vs additional AOX (aggregate effect of 0.02 and 0.13 AOX), 0.02 vs 0.13 AOX, 35 vs 100 VIT-E, and all possible interactions. Overall (d 0 to 40), interactions were observed (P < 0.05) between additional AOX and VIT-E level for d 40 BW (35 VIT-E: 22.0, 22.3, 22.8 kg; 100 VIT-E: 23.0, 22.8, 22.3 kg), ADG (35 VIT-E: 0.39, 0.40, 0.42 kg/d; 100 VIT-E: 0.42, 0.41, 0.40 kg/d), ADFI (35 VIT-E: 0.52, 0.52, 0.54 kg/d; 100 VIT-E: 0.55, 0.54, 0.52 kg/d, and return over feed cost (ROFC; 35 VIT-E: $27.16, 27.62, 28.29; 100 VIT-E: $28.83, 28.31, 27.50). Additionally, interactions were observed (P < 0.05) between AOX level, when increased from 0.02 to 0.13%, and VIT-E level for ADG, ADFI, ROFC, and probability for mortality and removals (35 VIT-E: 10.4, 13.6, 6.5%; 100 VIT-E: 8.4, 10.0, 9.7%). Level of AOX or VIT-E did not impact cost/kg of gain or feed efficiency (P > 0.10). Including AOX in 35 IU/kg VIT-E diets improved growth performance parameters and reduced probability for mortality and removals, but not in diets containing 100 IU/kg VIT-E.

APA, Harvard, Vancouver, ISO, and other styles

23

Wei, Wei, Langen Li, Yufeng Zhang, Geriletu, Jia Yang, Yanmei Zhang, and Yiqiao Xing. "Vitamin C Protected Human Retinal Pigmented Epithelium from Oxidant Injury Depending on Regulating SIRT1." Scientific World Journal 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/750634.

Full text

Abstract:

The purpose was to investigate the protective effects of Vitamin C (Vit C) and the regulatory mechanism between Vit C and sirtuin 1 (SIRT1) in PREs during oxidative stress as Vit C and SIRT1 exerted famous effects as antioxidants. We found that moderate Vit C (100 µM) prevented ARPE-19 cells from damages induced by H2O2, including increasing viability, reducing apoptosis, and attenuating intracellular ROS levels. But lower and higher concentration of Vit C had no effects. Further results indicated that Vit C caused the dysregulation of some stress responses factors (SIRT1, p53 and FOXO3) in ARPE-19 cells response to H2O2. Moreover we found that SIRT1 activator resveratrol (SRV) stimulated significantly the protective effects of moderate Vit C, provided the property of antioxidative stress for the lower and higher concentration of Vit C in ARPE-19 cells as well. Consistently, nicotinamide (NA) relieved the protective functions of moderate Vit C. Interestingly, data also revealed the dysregulation of p53 and FOXO3 was dependent on the regulation of SIRT1 rather than Vit C. Summarily, the protective effect of Vit C against oxidative stress was involved in regulation of SIRT1. It suggested that combined application of Vit C and RSV might be a promising therapeutic method for AMD.

APA, Harvard, Vancouver, ISO, and other styles

24

Finkelstein, Fredric O., Peter Juergensen, Suxin Wang, Sally Santacroce, Mark Levine, Peter Kotanko, Nathan W. Levin, and Garry J. Handelman. "Hemoglobin and Plasma Vitamin C Levels in Patients on Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 31, no. 1 (January 2011): 74–79. http://dx.doi.org/10.3747/pdi.2009.00154.

Full text

Abstract:

ObjectiveTo determine the contribution of vitamin C (Vit C) status in relation to hemoglobin (Hb) levels in patients on long-term peritoneal dialysis (PD).Methods56 stable PD patients were evaluated in a cross-sectional survey. Plasma samples were collected for Vit C (analyzed by HPLC with electrochemical detection) and high-sensitivity C-reactive protein (hs-CRP) determinations. Clinical records were reviewed for Hb, transferrin saturation (TSAT), ferritin, erythropoietin (EPO) dose, and other clinical parameters. Dietary Vit C intake was evaluated by patient survey and from patient records. Total Vit C removed during PD treatment was measured in 24-hour dialysate collections.ResultsPatients showed a highly skewed distribution of plasma Vit C levels, with 40% of patients below normal plasma Vit C levels (<30 μmol/L) and 9% at higher than normal levels (>80 μmol/L). Higher plasma Vit C levels were associated with higher Hb levels (Pearson r = 0.33, p < 0.004). No direct connection between Vit C levels and reported dietary intake could be established. In stepwise multiple regression, plasma Vit C remained significantly associated with Hb ( p = 0.017) but there was no significant association with other variables (dialysis vintage, age, ferritin, TSAT, hs-CRP, residual renal function, and EPO dose). In 9 patients that were evaluated for Vit C in dialysate, plasma Vit C was positively associated (Spearman r = 0.85, p = 0.01) with the amount of Vit C removed during dialysis treatment.ConclusionsThese data indicate that plasma Vit C is positively associated with higher Hb level. Vit C status could play a major role in helping PD patients to utilize iron for erythropoiesis and achieve a better Hb response during anemia management.

APA, Harvard, Vancouver, ISO, and other styles

25

Ludke, Ana R., Anita K. Sharma, Gauri Akolkar, Gunjan Bajpai, and Pawan K. Singal. "Downregulation of vitamin C transporter SVCT-2 in doxorubicin-induced cardiomyocyte injury." American Journal of Physiology-Cell Physiology 303, no. 6 (September 15, 2012): C645—C653. http://dx.doi.org/10.1152/ajpcell.00186.2012.

Full text

Abstract:

Vitamin C (Vit C) has been shown to be protective against doxorubicin (Dox)-induced cardiotoxicity. However, Vit C uptake into cardiomyocytes is poorly understood. Furthermore, whether the antioxidant enzyme reserve is enhanced by Vit C is also not known. The present study investigated an influence of Dox on Vit C transporters, expression of endogenous antioxidant reserve as well as enzymes, oxidative stress, and apoptosis in isolated cardiomyocytes. Cardiomyocytes isolated from adult Sprague-Dawley rats were exposed to control (culture medium 199 alone), Dox (10 μM), Vit C (25 μM), and Vit C + Dox for 24 h. Vit C transporter expression and localization, oxidative stress, antioxidant enzymes, and apoptosis were studied. Expression and localization of sodium-dependent vitamin C transporter-2 (SVCT-2) in the sarcolemma was reduced by Dox, but Vit C supplementation was able to blunt this change. There was a decrease in the expression of antioxidant enzymes glutathione peroxidase (GPx), catalase, and Cu/Zn superoxide dismutase (SOD) due to Dox, but only GPx expression was completely prevented and Cu/Zn SOD was partially rescued by Vit C. Dox-induced decrease in antioxidant reserve and increase in oxidative stress were partially mitigated by Vit C. Dox-induced apoptosis was ameliorated by Vit C. It is suggested that cardioprotection offered by Vit C in Dox-induced cardiomyopathy may involve an upregulation of SVCT-2 transporter followed by a reduction in oxidative stress as well as blunting of cardiomyocyte injury.

APA, Harvard, Vancouver, ISO, and other styles

26

Elsamany, Shereef, Omaima Elemam, Ahmed Zeeneldin, Soha Elmorsy, Ahmed Khatry, Faisal Alhuthali, and Suha Alsayed. "Prognostic value of vitamin-D level in non-metastatic breast cancer patients in Saudi Arabia." Asian Pacific Journal of Cancer Care 1, no. 1 (February 3, 2020): 9–14. http://dx.doi.org/10.31557/apjcc.2020.1.1.9-14.

Full text

Abstract:

Background Deficiency of vitamin-D (Vit-D) was associated with poor survival outcome in several studies across different tumour types. The present study aims to assess the prevalence and prognostic value of Vit-D deficiency among breast cancer patients in a single institution in Saudi Arabia. Methods In this retrospective study, we screened patients who presented with non-metastatic breast cancer to King Abdullah Medical City, Saudi Arabia from June 2011 to December 2015. We checked baseline Vit-D level before starting systemic therapy in addition to other clinicopathological factors. Low Vit-D was defined as Vit-D level less than 30 ng /ml. The relations of Vit-D level (taking the median as the cutoff) with clinicopathological factors were assessed using Chi-Square test. Differences in survival outcome were compared using log rank test. Results We screened 340 patients with non-metastatic breast cancer. Baseline Vit-D levels were available for 189 patients. The median age was 50 years (range: 26- 86 years). Noteworthy, 169 (89.4%) of patients had Vit-D level <30 ng/ml with a median of 14.9 ng/ml (range: 4.0 - 45.0). Low Vit-D level (below the median) was significantly more common in premenopausal (p=0.011) and ER-negative patients (p=0.011). However, lymphovascular invasion (p=0.001), clinically (p=0.023) and pathologically positive axillary LNs (p=0.041) were linked with higher Vit- D level. After a median follow up period of 58.2 months, 14 patients died and 40 relapsed. The 5-year disease-free survival (DFS) rates was 74.8%. The 5-year DFS rate in patients with higher Vit-D level above the median was 78.8% compared to 71.1% in patients with lower Vit-D level with no statistically significance difference (p= 0.22). The 5-year overall survival (OS) rate was 90.2%. Meanwhile, no difference in 5-year OS rate in patients with higher and lower Vit-D levels (90.3% and 89.7% respectively, p=0.6). Conclusion Low Vit-D level was prevalent among the studied breast cancer patients. Low Vit-D level was associated with ER-negative phenotype and premenopausal patients. Baseline Vit-D level was not significantly linked with survival outcome.

APA, Harvard, Vancouver, ISO, and other styles

27

Elsamany, Shereef, Omaima Elemam, Ahmed Zeeneldin, Soha Elmorsy, Ahmed Khatry, Faisal Alhuthali, and Suha Alsayed. "Prognostic value of vitamin-D level in non-metastatic breast cancer patients in Saudi Arabia." Asian Pacific Journal of Cancer Care 5, no. 1 (February 10, 2020): 9–14. http://dx.doi.org/10.31557/apjcc.2020.5.1.9-14.

Full text

Abstract:

Background Deficiency of vitamin-D (Vit-D) was associated with poor survival outcome in several studies across different tumour types. The present study aims to assess the prevalence and prognostic value of Vit-D deficiency among breast cancer patients in a single institution in Saudi Arabia. Methods In this retrospective study, we screened patients who presented with non-metastatic breast cancer to King Abdullah Medical City, Saudi Arabia from June 2011 to December 2015. We checked baseline Vit-D level before starting systemic therapy in addition to other clinicopathological factors. Low Vit-D was defined as Vit-D level less than 30 ng /ml. The relations of Vit-D level (taking the median as the cutoff) with clinicopathological factors were assessed using Chi-Square test. Differences in survival outcome were compared using log rank test. Results We screened 340 patients with non-metastatic breast cancer. Baseline Vit-D levels were available for 189 patients. The median age was 50 years (range: 26- 86 years). Noteworthy, 169 (89.4%) of patients had Vit-D level <30 ng/ml with a median of 14.9 ng/ml (range: 4.0 - 45.0). Low Vit-D level (below the median) was significantly more common in premenopausal (p=0.011) and ER-negative patients (p=0.011). However, lymphovascular invasion (p=0.001), clinically (p=0.023) and pathologically positive axillary LNs (p=0.041) were linked with higher Vit- D level. After a median follow up period of 58.2 months, 14 patients died and 40 relapsed. The 5-year disease-free survival (DFS) rates was 74.8%. The 5-year DFS rate in patients with higher Vit-D level above the median was 78.8% compared to 71.1% in patients with lower Vit-D level with no statistically significance difference (p= 0.22). The 5-year overall survival (OS) rate was 90.2%. Meanwhile, no difference in 5-year OS rate in patients with higher and lower Vit-D levels (90.3% and 89.7% respectively, p=0.6). Conclusion Low Vit-D level was prevalent among the studied breast cancer patients. Low Vit-D level was associated with ER-negative phenotype and premenopausal patients. Baseline Vit-D level was not significantly linked with survival outcome.

APA, Harvard, Vancouver, ISO, and other styles

28

Spieth, J., and T. Blumenthal. "The Caenorhabditis elegans vitellogenin gene family includes a gene encoding a distantly related protein." Molecular and Cellular Biology 5, no. 10 (October 1985): 2495–501. http://dx.doi.org/10.1128/mcb.5.10.2495.

Full text

Abstract:

While the nematode Caenorhabditis elegans is more primitive than most egg-laying organisms, it's vitellogenins, or yolk protein precursors, appear to be more complex. C. elegans oocytes accumulate two major classes of yolk proteins. The first consists of two polypeptides with an Mr of about 170,000 (yp170A and yp170B) encoded by a family of five closely related genes called vit-1 through vit-5. The second class consists of two smaller proteins with Mr values of 115,000 (yp115) and 88,000 (yp88) which are cut from a single precursor. Here we report the cloning and analysis of a single-copy gene (vit-6) that encodes this precursor. The lengths of the gene and its mRNA are about 5 X 10(3) base pairs. Like vit-1 through vit-5, vit-6 is expressed exclusively in adult hermaphrodites. Comparison of portions of the coding sequence indicates that vit-6 is distantly related to the vit-1 through vit-5 gene family. Thus, even though the two classes of yolk proteins are antigenically and physically distinct, they are encoded by a single highly diverged gene family.

APA, Harvard, Vancouver, ISO, and other styles

29

Spieth, J., and T. Blumenthal. "The Caenorhabditis elegans vitellogenin gene family includes a gene encoding a distantly related protein." Molecular and Cellular Biology 5, no. 10 (October 1985): 2495–501. http://dx.doi.org/10.1128/mcb.5.10.2495-2501.1985.

Full text

Abstract:

While the nematode Caenorhabditis elegans is more primitive than most egg-laying organisms, it's vitellogenins, or yolk protein precursors, appear to be more complex. C. elegans oocytes accumulate two major classes of yolk proteins. The first consists of two polypeptides with an Mr of about 170,000 (yp170A and yp170B) encoded by a family of five closely related genes called vit-1 through vit-5. The second class consists of two smaller proteins with Mr values of 115,000 (yp115) and 88,000 (yp88) which are cut from a single precursor. Here we report the cloning and analysis of a single-copy gene (vit-6) that encodes this precursor. The lengths of the gene and its mRNA are about 5 X 10(3) base pairs. Like vit-1 through vit-5, vit-6 is expressed exclusively in adult hermaphrodites. Comparison of portions of the coding sequence indicates that vit-6 is distantly related to the vit-1 through vit-5 gene family. Thus, even though the two classes of yolk proteins are antigenically and physically distinct, they are encoded by a single highly diverged gene family.

APA, Harvard, Vancouver, ISO, and other styles

30

Zhang, Bo, Lu Liu, Shiwen Zhao, Xu Wang, Liyang Liu, and Shao Li. "Vitexicarpin Acts as a Novel Angiogenesis Inhibitor and Its Target Network." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–13. http://dx.doi.org/10.1155/2013/278405.

Full text

Abstract:

Vitexicarpin (VIT) isolated from the fruits ofVitex rotundifoliahas shown antitumor, anti-inflammatory, and immunoregulatory properties. This work is designed to evaluate the antiangiogenic effects of VIT and address the underlying action mechanism of VIT by a network pharmacology approach. The results validated that VIT can act as a novel angiogenesis inhibitor. Firstly, VIT can exert good antiangiogenic effects by inhibiting vascular-endothelial-growth-factor- (VEGF-) induced endothelial cell proliferation, migration, and capillary-like tube formation on matrigel in a dose-dependent manner. Secondly, VIT was also shown to have an antiangiogenic mechanism through inhibition of cell cycle progression and induction of apoptosis. Thirdly, VIT inhibited chorioallantoic membrane angiogenesis as well as tumor angiogenesis in an allograft mouse tumor model. We further addressed VIT’s molecular mechanism of antiangiogenic actions using one of our network pharmacology methods named drugCIPHER. Then, we tested some key molecules in the VEGF pathway targeted by VIT and verified the inhibition effects of VIT on AKT and SRC phosphorylation. Taken together, this work not only identifies VIT as a novel potent angiogenesis inhibitor, but also demonstrates that network pharmacology methods can be an effective and promising approach to make discovery and understand the action mechanism of herbal ingredients.

APA, Harvard, Vancouver, ISO, and other styles

31

Ha, Si Young, Ji Young Jung, Hee Young Kang, Tae-Heung Kim, and Jae-Kyung Yang. "Tyrosinase activity and melanogenic effects of Lespedeza bicolor extract in vitro and in vivo." BioResources 15, no. 3 (July 1, 2020): 6244–61. http://dx.doi.org/10.15376/biores.15.3.6244-6261.

Full text

Abstract:

Lespedeza bicolor (L. bicolor) is used for medicinal purposes because of its various biological and pharmacological activities. In this study, the effects of L. bicolor ethanol extract on the treatment of vitiligo were investigated. The determination of melanin content in melanocytes was measured using B16 melanoma cells and C57BL/6J Ler-vit/vit mice. Finally, the quercetin content in L. bicolor were qualitatively analyzed using HPLC. The results obviously indicated that the L. bicolor extract enhanced melanogenesis and increased tyrosinase activity in cultured melanoma cells and C57BL/6J Ler-vit/vit mice. Treatment with L. bicolor extract led to a higher content of melanin and eumelanin in C57BL/6J Ler-vit/vit mice hair than in control (untreated) mice, which demonstrated the therapeutic effect of hair-graying associated with vitiligo. There was a notable increase in melanocytes in the skin of C57BL/6J Ler-vit/vit mice treated with L. bicolor extract compared with the control. L. bicolor extract was a potent tyrosinase and melanin synthesis activator in B16 melanoma cells. C57BL/6J Ler-vit/vit mice treated with L. bicolor extract had significantly higher melanin content in hair than the untreated control. The results suggest that L. bicolor extract is a potential alternative treatment for improvement of vitiligo.

APA, Harvard, Vancouver, ISO, and other styles

32

Batsi, Christina, Evangelia Gkika, Loukas Astrakas, Athanassios Papadopoulos, Ioannis Iakovou, Alexandros Dogoritis, Andreas Fotopoulos, and Chrissa Sioka. "Vitamin D Deficiency as a Risk Factor for Myocardial Ischemia." Medicina 57, no. 8 (July 29, 2021): 774. http://dx.doi.org/10.3390/medicina57080774.

Full text

Abstract:

Background and Objectives: Vitamin D (Vit D) deficiency has been implicated in various conditions, including cardiovascular disease. The purpose of this retrospective study was to investigate the incidence of patients with myocardial ischemia in relation to their serum levels of vitamin D. Materials and Methods: A 64-month search (January 2016 to April 2021) in our database of the Nuclear Medicine Laboratory revealed 113 patients who had both myocardial perfusion imaging with single photon emission computed tomography (MPI SPECT) and Vit D measurements. MPI SPECT obtained myocardial images during both stress (summed stress score, SSS) and rest (summed rest score, SRS). Abnormal MPI SPECT was when the SSS was ≥4. Vit D was determined by radioimmunoassay (RIA). Patients with Vit D values <10 ng/mL, 10–29 ng/mL and ≥30 ng/mL were defined as having a deficiency, insufficiency and sufficiency, respectively. Results: Among patients, 46/113 (40.7%) were male and 67/113 (59.3%) were female. Abnormal MPI was found in 58/113 (51.3%) patients. Vit D deficiency was noted in 20/113 (17.7%) patients, insufficiency in 86/113 (76.1%) patients, and normal Vit D was noted in only 7/113 (6.2%) patients. Sixteen of the 20 patients (80%) with Vit D deficiency, and 38/86 (44.2%) with insufficiency had an abnormal MPI SPECT. In contrast, only 1/7 (14.3%) patients with sufficient Vit D levels had an abnormal MPI SPECT. The Mann-Whitney U-test showed that ischemia reduced the values of Vit D. Correlation analysis showed a negative association of Vit D levels with SSS (rho = −0.232, p = 0.014) and SRS (rho = −0.250, p = 0.008). Further evaluation with a Vit D cut off 20 ng/mL retrieved no statistical significance. Finally, Vit D and gender were independently associated with myocardial ischemia. Conclusions: Low Vit D levels may represent a risk factor for myocardial ischemia.

APA, Harvard, Vancouver, ISO, and other styles

33

BAUCHAU, Henry. "« On ne vit que lorsqu’on aime / On ne vit que si l’on saigne »." Revue internationale Henry Bauchau. L’écriture à l’écoute, no. 7 (November 25, 2015): 13–59. http://dx.doi.org/10.14428/rihb.v0i7.17493.

Full text

Abstract:

Henry Bauchau avait rédigé en 1956 l’ébauche d’une pièce de théâtre consacrée au personnage de Spartacus : 64 feuillets manuscrits et 11 feuillets tapuscrits. Il s’agit donc de la révolte des esclaves guidée par le gladiateur évadé Spartacus, à laquelle ont mis fin Crassus et Pompée en 71 ACN. La transcription intégrale du texte occupe les pages 24 à 59. Transcription, présentation et commentaires par Pauline Basso et Jérémy Lambert (jeremy-lambert@hotmail.com).

APA, Harvard, Vancouver, ISO, and other styles

34

Clements, Ronald H., Kishore Yellumahanthi, Mary Wesley, Naveen Ballem, and Kirby I. Bland. "Hyperparathyroidism and Vitamin D Deficiency after Laparoscopic Gastric Bypass." American Surgeon 74, no. 6 (June 2008): 469–75. http://dx.doi.org/10.1177/000313480807400603.

Full text

Abstract:

Hyperparathyroidism (HPT) can occur after gastric bypass because of the alteration in vitamin D and calcium absorption. Adequate serum vitamin D concentrations have not been clearly defined in this patient population. Vitamin D (Vit D) and parathyroid hormone (PTH) were assessed 1 year after laparoscopic gastric bypass (LGB). The prevalence of HPT and Vit D deficiency were determined and their association was evaluated using Fisher's exact test. Ninety-three patients (aged 44 ± 1.1 years, 49.6 ± 0.67 kg/m2 body mass index, 79.6% female, 69.6% white) were evaluated. The prevalence of Vit D deficiency (less than 20 ng/mL) and HPT (greater than 65 pg/mL) was 23.6 per cent (n = 22) and 25.7 per cent (n = 28), respectively. Among patients with HPT, only eight of 28 (28.6%) had Vit D deficiency, and of those with Vit D deficiency, only eight of 22 (36.4%) had HPT. There was a weak inverse correlation (r = –0.37) between PTH and Vit D. Blacks are at higher risk for Vit D deficiency. There was no significant association between Vit D deficiency and HPT, Vit D deficiency and Roux limb length, or HPT and Roux limb length. After LGB, Vit D deficiency and hyperparathyroidism occur commonly. Body mass index and Roux limb length are not associated with these two conditions, but racial differences do exist. There is a weak inverse correlation between Vit D and PTH. Further research is needed to elucidate the causes, treatments, and significance of HPT after LGB.

APA, Harvard, Vancouver, ISO, and other styles

35

Bhargava, Ranjana S., Yue Zhu, Chana Weinstock, Nader Hanna, Katherine Hanna Tkaczuk, Ting Bao, and Saranya Chumsri. "Association between vitamin D deficiency and breast cancer histology: A retrospective database review." Journal of Clinical Oncology 30, no. 15_suppl (May 20, 2012): 1039. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.1039.

Full text

Abstract:

1039 Background: Vitamin D (Vit D) deficiency has been shown to be associated with a higher risk of developing breast cancer. Inverse association has also been shown between vit D level and tumor size. However, the association between vit D deficiency and breast cancer histology remains unclear. Preclinical data has suggested that vit D plays an essential role in the terminal differentiation of breast cells. Thus, we hypothesize that vit D deficiency would be associated with estrogen receptor-negative tumors, particularly triple-negative breast cancers (TNBC) which are associated with aggressive clinical course. Methods: We conducted a retrospective database review to obtain information including age, race, tumor histology, size, stage, and vit D levels in newly diagnosed breast cancer patients at University of Maryland Greenebaum Cancer Center. Results: 150 patients presented between July 2008 and August 2011 were included in this analysis. Average age at diagnosis was 57 (range 30-87), and 56% of patients were African American. Overall, 80% of the patients were vit D deficient at diagnosis, with levels < 30 ng/ml. African-American patients were more likely to be severely vit D deficient with levels < 10 ng/ml compared to Caucasians (33% vs. 7.5%, p= 0.0002). Patients with TNBC were more likely to be vit D deficient at diagnosis compared to hormone receptor-positive patients (93% vs. 76%, p =0.015). These patients also had the lowest mean (18) and median (16) of vit D levels compared to all other patients. This difference is also statistically significant in multivariate analysis when adjusted for age, race, and stage (OR 3.96; p=0.04). Regardless of the ER/PR status, Her 2 negative patients were more vit D deficient compared to Her 2 positive patients (86% vs. 61%, p=0.001). Unlike previous studies, no correlation was seen between tumor size and vit D levels. Furthermore, there is also no association between stage, nodal involvement, or Ki67 and vit D level. Conclusions: Vit D deficiency is common among patients with newly-diagnosed breast cancer, particularly African American patients. Patients with TNBC have a significantly higher likelihood of being vit D deficient than patients with other histological subtypes.

APA, Harvard, Vancouver, ISO, and other styles

36

Kadivec, Sasa, and Mitja Kosnik. "Benefits of venom immunotherapy: How soon can they be expected." Srpski arhiv za celokupno lekarstvo 145, no. 3-4 (2017): 173–77. http://dx.doi.org/10.2298/sarh160307032k.

Full text

Abstract:

Introduction/Objective. Allergic reactions to insect stings are medical emergencies that could be prevented by venom immunotherapy (VIT). The main purpose of VIT is to prevent fatal or life-threatening reactions. We aimed to show the rapidity with which patients experience the benefits of VIT and estimate the number of emergency treatments that are prevented. Methods. We reviewed the medical files of patients who started VIT between 2010 and 2014. We calculated the costs of treatment of the sting reactions, the costs of immunotherapy, and estimated the costs of prevented allergic reactions. Results. In a cohort of 514 patients (40.9% female, age 47.2 ? 14.4 years), the cost of treatment of the index sting reaction was 180.4 ? 166.8 euros. During VIT, 195 patients experienced 446 field stings. In 86.3% of patients, stings were well tolerated, and only one patient experienced a severe reaction (grade III, according to Mueller). A total of 20.4% of VIT treated patients were stung during the first year of VIT and 57% during five years of VIT. The expenditure for five years of VIT was 2,886 euros per patient, which corresponded to an average of 16 emergency treatments for systemic reactions. Conclusion. Emergency situations are prevented in a substantial number of venom-allergic patients and a beneficial effect was already observed during the first year of VIT.

APA, Harvard, Vancouver, ISO, and other styles

37

Gonzales Chaves, Macarena M. S., Clarisa Marote, Gretel G. Pellegrini, Andrés Pighin, Maria C. de Landeta, Fima Lifshitz, Silvia M. Friedman, Patricia Mandalunis, and Susana N. Zeni. "BONE MASS RECOVERY OF OSTEOPENIC VITAMIN D INSUFFICIENT RATS FROM STRONTIUM RANELATE TREATMENT: DOES THE RESPONSE DEPEND ON VITAMIN D NUTRITIONAL STATUS OR ON SOURCE OF VITAMIN D (D2 VERSUS D3)?" Journal of Musculoskeletal Research 13, no. 03 (September 2010): 95–108. http://dx.doi.org/10.1142/s0218957710002582.

Full text

Abstract:

It was investigated if Vitamin D (Vit D) status or source (Vitamin D2 vs. Vitamin D3) interferes with bone mass recovery from strontium ranelate (SrRa) treatment of rats with Vit D insufficiency and established osteopenia. Osteopenic and Vit D insufficient rats were divided in groups to complete a 105-day period. First experiment: The rats were fed with diets that only varied in Vit D (100 vs. 0 IU%) and/or SrRa (0 vs. 900 mg/kg/day) content. A SHAM group received Vit D throughout the experience. Second experiment: Rats were divided into groups and received Vit D2 or Vit D3 through diet and SrRa by gavages in a fasting state. Two SHAM groups received Vit D2 or Vit D3 throughout the study. Results: Levels of 25-hydroxyvitamin 25OHD were reduced in groups lacking dietary Vit D (p < 0.001). Independently of Vit D status or source, SrRa did not affect body weight gain or bone alkaline phosphatase levels; osteocalcin and C-terminal telopeptide of type I collagen levels were reduced (p < 0.05) and bone Sr content was increased (p < 0.0001). Although no improvement in biomechanical parameters was observed, total skeletal bone mineral content and proximal tibial bone mineral density were increased (p < 0.05). There was a reduction in the trabecular number and an increase in the trabecular surface and bone volume without reaching SHAM levels. Conclusion: This is the first study that examined SrRa effects in an osteopenic vitamin D–insufficient experimental model. Under our experimental conditions, SrRa increased bone Sr content independently of Vit D status or source; however, no evidence of an anabolic or antifracture effect was found, and only a slight decrease in some bone resorption parameters was observed.

APA, Harvard, Vancouver, ISO, and other styles

38

Werneke, Ursula, Fiona Gaughran, and David M. Taylor. "Vitamin D in the time of the coronavirus (COVID-19) pandemic – a clinical review from a public health and public mental health perspective." Therapeutic Advances in Psychopharmacology 11 (January 2021): 204512532110276. http://dx.doi.org/10.1177/20451253211027699.

Full text

Abstract:

Individuals with serious mental disorders (SMD) may have a higher risk of vitamin D (VIT-D) deficiency. They also experience higher mortality because of coronavirus disease 2019 (COVID-19) infection. Therefore, we have conducted a comprehensive review to examine the significance of VIT-D for public health and public mental health during the ongoing COVID-19 pandemic. This review had three specific aims, from a global perspective to (a) create a profile of VIT-D and review the epidemiology of VIT-D deficiency, (b) explore VIT-D deficiency as risk factor for SMD and COVID-19 infections and (c) examine the effectiveness of VIT-D supplementation for both conditions. We found that, in terms of SMD, the evidence from laboratory and observational studies points towards some association between VIT-D deficiency and depression or schizophrenia. Mendelian randomisation studies, however, suggest no, or reverse, causality. The evidence from intervention studies is conflicting. Concerning COVID-19 infection, on proof of principle, VIT-D could provide a plausible defence against the infection itself and against an adverse clinical course. But data from observational studies and the first preliminary intervention studies remain conflicting, with stronger evidence that VIT-D may mitigate the clinical course of COVID-19 infection rather than the risk of infection in the first place. From a public health and public mental health point of view, based on the currently limited knowledge, for individuals with SMD, the benefits of VIT-D optimisation through supplementation seem to outweigh the risks. VIT-D supplementation, however, should not substitute for vaccination or medical care for COVID-19 infection.

APA, Harvard, Vancouver, ISO, and other styles

39

Dashputra, Amruta V., Rupesh T. Badwaik, Archana S. Borker, Amit P. Date, and Priyanka Survase. "Vitamin D: prescription audit in tertiary health care centre." International Journal of Basic & Clinical Pharmacology 6, no. 9 (August 22, 2017): 2163. http://dx.doi.org/10.18203/2319-2003.ijbcp20173737.

Full text

Abstract:

Background: Vitamin-D is critically important for development, growth and maintenance of health of human being. Many evidences show association between vit-D deficiency and several serious health conditions. Data collection on use of drugs is being obtained with the aim of optimizing drug therapy. So far till date only few studies about prescription pattern of vit-D have been found. Hence it is very important to do audit of prescriptions of vit-D. The aim of the study is to provide concise and updated information about the use of vit-D in tertiary care hospital and to record demographic details of patients.Methods: After ethical approval, this cross sectional study was conducted at tertiary health centre. Patient and drug data (name of drug, dose, dosage form and route of administration) was collected from the patient’s prescriptions in OPD.Results: Highest prescriptions of vit-D were found in orthopedic department (22% of total prescriptions of that department). Prescribing percentage of vit-D in medicine department was 4.6%, dermatology 1.5% and in psychiatry 0.8% of total prescriptions. Prescriptions of vit-D in combination with calcium were found in orthopedics (52%), medicine (7%) and obstetrics and gynecology (10%) departments.Conclusions: Highest prescriptions of vit-D alone and with calcium found in orthopedic department. Periodic therapeutic audit is necessary to rationalise the use of vit D.

APA, Harvard, Vancouver, ISO, and other styles

40

Gupta, Amit, and Sachin Kumar. "Correlation of vitamin D level with its related biochemical parameters and impact of different treatment regimens on their correction." International Journal of Contemporary Pediatrics 8, no. 1 (December 23, 2020): 86. http://dx.doi.org/10.18203/2349-3291.ijcp20205511.

Full text

Abstract:

Background: Vit D is a fat-soluble vitamin that is produced when ultraviolet rays from sunlight strike the skin and trigger vit D synthesis. Aims and Objectives of the study were to find out the correlation of vit D level with its related biochemical parameters and impact of two different treatment regimens on their correction. Methods: A total of 107 patients were followed up out of which 89 were vit D deficient and rest were vit D insufficient. Results: Mean age of the patients was 6.11±4.49 and males comprised 66%. Mean BMI of children included in group A, B and C was 19.40±2.69, 19.60±3.18 and 20.95±3.72 kg/m2 respectively. Vit D levels at baseline had a significant inverse correlation with ALP (r=-0.27, p value=0.008). Before and after comparison of mean serum calcium levels revealed significant improvement in both the treatment groups. Severity of vit D deficiency, at baseline, 9.10, 77.30 and 13.60% of patients had vit D levels of less than 5, 5 to 15 and more than 15 for group A respectively. In group B at baseline, 6.70, 71.10 and 22.20% of patients had vit D levels of less than 5, 5 to 15 and more than 15 respectively.Conclusions: Present study found that 60,000 IU/week and dose of 2000 IU/day for infants or 5000 IU/day for 1 to 18 years of age, along with 500 to 800 mg oral calcium for 6 to 8 weeks can result in correction of vit D deficiency.

APA, Harvard, Vancouver, ISO, and other styles

41

Perez-Soler, R., Y. Zou, T. Li, C. Tornos, and Y. Ling. "Topical vitamin K3 (Vit K3, Menadione) prevents erlotinib and cetuximab-induced EGFR inhibition in the skin." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 3036. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.3036.

Full text

Abstract:

3036 Background: The EGFR inhibitors erlotinib and cetuximab cause skin toxicity in about 75% of patients. The occurrence of skin toxicity correlates with clinical benefit. About half the patients with skin toxicity report significant discomfort. There are currently no scientifically based or proven methods for preventing or treating effectively the skin toxicity secondary to EGFR inhibitors. Methods: We screened a number of EGFR activators and phosphatase inhibitors for their ability to abrogate EGFR inhibition secondary to erlotinib and cetuximab in A431 cells. P-EGFR expression was assessed by western blot analysis. Vit K3 was selected for further in vivo studies. The skin toxicity secondary to the topical application of Vit K3 was evaluated in nude mice. The highest non-toxic concentration was used to determine the ability of topical Vit K3 to prevent EGFR inhibition in the skin of nude mice treated with EGFR inhibitors. Results: Vit K3 was the most potent EGFR activator identified, the maximum effect being observed at concentrations of 0.1–0.5 mM. In the presence of erlotinib or cetuximab, 0.1- 0.5 mM Vit K3 completely prevented EGFR inhibition. The maximum non-toxic concentration of Vit K3 applied topically BID × 10 days to nude mice was 15 mM. At this concentration, topical Vit K3 caused P-EGFR upregulation in the skin. In animals treated with erlotinib (100 mg/kg daily × 5 days), there was no detectable P-EGFR expression in the skin not treated with topical Vit K3 whereas P-EGFR expression was completely restored in the skin treated BID x 5 days with topical Vit K3. Conclusions: Vit K3 is one of the first reported agents to prevent/reverse EGFR inhibition secondary to anti-EGFR agents. The results strongly justify the development of a topical formulation of Vit K3 to treat and prevent the cutaneous toxicity secondary to EGFR inhibitors. [Table: see text]

APA, Harvard, Vancouver, ISO, and other styles

42

Tengour, Habib. "Ta voix vit / Nous vivons." Po&sie 153-154, no. 3 (2015): 185. http://dx.doi.org/10.3917/poesi.153.0185.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

Filser, Marc, and Eric Vernette. "La théorie marketing vit encore…" Décisions Marketing 62 (April 1, 2011): 05–06. http://dx.doi.org/10.7193/dm.062.05.06.

Full text

APA, Harvard, Vancouver, ISO, and other styles

44

Monjaret, Anne. "« On vit avec les rats »." Communications 105, no. 2 (2019): 107. http://dx.doi.org/10.3917/commu.105.0107.

Full text

APA, Harvard, Vancouver, ISO, and other styles

45

Dhawan, Ritwik, Kabir Zaidi, and V. Suneetha. "Automatic Remote VIT Water Purifier." Research Journal of Pharmacy and Technology 10, no. 2 (2017): 434. http://dx.doi.org/10.5958/0974-360x.2017.00087.7.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

. "1316 Vit Onderzocht Aanbestedingen Thuiszorg." Zorg en Financiering 5, no. 10 (October 2006): 22. http://dx.doi.org/10.1007/bf03093139.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Ha, A. N., K. L. Lee, Md Fakruzzaman, S. S. Kim, P. R. Park, J. I. Jin, S. H. Hyon, and I. K. Kong. "52 EFFECT OF CARBOXYLATED POLY-L-LYSINE ON THE POST-THAW VIABILITY OF IN VITRO-PRODUCED BOVINE BLASTOCYST." Reproduction, Fertility and Development 27, no. 1 (2015): 119. http://dx.doi.org/10.1071/rdv27n1ab52.

Full text

Abstract:

Recently, there has been development of an antifreeze polyamino acid (carboxylated poly-l-lysine: PLL) as new cryoprotectants (CPA). This compound counts as amphoteric macromolecular cationic and anionic substituents (polyampholyte) by chemically modifying poly-lysine. In addition, PLL is highly safe and frequently used as a food additive in substitution for other CPA. Other common CPA have high toxicity and caused physiological damage. In vitro-produced blastocysts were randomly assigned into 3 groups: (1) vitrified embryos with PLL vitrification solution [PLL-vit-1: 15% PLL + 15% ethylene glycol (EG); PLL-vit-2: 30% PLL + 30% EG + 0.5 M sucrose], (2) vitrified embryos with Vajta et al. solution (Conv-vit-1: 7.5% dimethyl sulfoxide + 7.5% EG; Conv-vit-2: 16.5% dimethyl sulfoxide + 16.5% EG + 0.5 M sucrose), and (3) nonvitrified blastocysts (control). All embryos were frozen by droplet vitrification method. First, the PLL-vitrified embryos were exposed to 5, 10, and 15 min in the PLL-vit-1 and then putted for 30 to about 60 s in the PLL-vit-2. Then, we compared with each group regarding exposure time of Vit-1. Post-thaw survival rate of each exposure time did not significantly differ among the 3 groups (100 v. 100 v. 100%). However, hatching rate of the 10-min exposure group was higher than that of 5- and 15-min groups (75.0 v. 25.0 v. 66.7; P < 0.05). Therefore, we confirmed that exposure time of Vit-1 was exposed for a minimum of 10 min. The post-thawed survival rate of each vitrification method was not significantly different between PLL-vit and Conv-vit groups (97.7 v. 86.4%). The total cell numbers of blastocyst did not significantly differ among groups. However, the apoptotic cell numbers of blastocyst was significantly different between the control and Conv-vit groups (0.4 ± 0.6 v. 4.4 ± 3.9; P < 0.05) but was not different in control v. PLL-vit (0.4 ± 0.6 v. 2.1 ± 2.4) and Conv-vit v. PLL-vit (4.4 ± 3.9 v. 2.1 ± 2.4). In conclusion, PLL-vit for bovine blastocyst could reduce toxicity and osmotic shock and showed high efficiency on the quality of post-thawed bovine blastocysts compared with that of Conv-vit.This work was partly supported by a grant from the Next-Generation BioGreen 21 Program (No. PJ009587022014), IPET (Grant No. 112020-3), and a scholarship from the BK21 plus program. A-Na Ha, Kyeong-Lim Lee, and Md. Fakruzzaman were supported by BK21 plus fellowships at Gyeongsang National University, Republic of Korea.

APA, Harvard, Vancouver, ISO, and other styles

48

Bahrami, Afsane, and Amirhossein Sahebkar. "Vitamin D as a Potential Therapeutic Option in Cancer Treatment: Is There a Role for Chemoprevention?" Anti-Cancer Agents in Medicinal Chemistry 20, no. 18 (November 23, 2020): 2138–49. http://dx.doi.org/10.2174/1871520620999200729192728.

Full text

Abstract:

Background: Vitamin D (Vit D) serves as a precursor to the potent steroid hormone calcitriol, which regulates numerous genes that control homeostasis, epithelial cell differentiation, proliferation, and apoptosis. Low level of Vit D is implicated in the development and progression of several diseases including bone fractures, cardiovascular disease, diabetes mellitus, and cancers. The present review highlights the role of vitamin D in cancer with a particular emphasis on genetic variants related to Vit D metabolism as well as clinical trials of Vit D supplementation as a potential therapeutic option in the treatment of cancer patients. Methods: Data were collected following an electronic search in the Web of Science, Medline, PubMed, and Scopus databases by using some keywords such as “cancer”, “tumor”, “malignancy”, “vitamin D”, “cholecalciferol” and “calcitriol”. Results: The collected evidence from the studies revealed a consistent and strong association between Vit D status and cancer risk and survival. The associations between Vit D-related genetic variants and cancer survival support the hypothesis that Vit D may affect cancer outcomes. The mechanisms whereby Vit D reduces cancer risk and increases survival are regulation of cellular differentiation, proliferation and apoptosis as well as decreased angiogenesis in tumor microenvironment and inhibition of metastasis. Conclusion: There is a paucity of evidence-based recommendations for the optimal 25(OH)D levels in patients with cancer and the role of Vit D supplementation for primary or secondary prevention of cancer. Well-designed and sufficiently powered randomized clinical trials are necessary to assess the clinical application of Vit D in enhancing the clinical efficacy of standard and adjuvant chemotherapy regimens.

APA, Harvard, Vancouver, ISO, and other styles

49

Jafari, Tina, Leila Mahmoodnia, and Mohsen Saeedi. "Effects of Pomegranate Peel Extract and Vitamin E on Quality of Life in Hemodialysis Patients: A Randomized Placebo-Controlled Clinical Trial." International Journal of Epidemiologic Research 7, no. 3 (September 28, 2020): 129–35. http://dx.doi.org/10.34172/ijer.2020.23.

Full text

Abstract:

Background and aims: Quality of life (QOL) is poor in hemodialysis (HD) patients. High oxidative stress and inflammatory conditions disturb their normal physiological, emotional, and physical functions. This study aimed to assess the effects of pomegranate peel extract (PPE) alone and in combination with vitamin E (Vit E) as anti-oxidant and anti-inflammatory substances on QOL of HD patients using Short-form 36 (SF-36) QOL questionnaire. Methods: This study was a double-blinded, placebo-controlled randomized clinical trial on HD patients. A total of 100 HD patients were randomly divided into 4 equal groups as follows: Pom+Vit E group, which received 2 PPE tablets + 1 Vit E soft gel daily, Pom group, which received 2 PPE tablets+1 Vit E placebo soft gel daily, Vit E group, which received 1 Vit E soft gel+2 PPE placebo tablets daily, and Placebo group, which received 2 PPE placebo tablets + 1 Vit E placebo soft gel daily. The intervention duration was 8 weeks. The stratified block randomization method based on sex, age, HD duration, and employment status was used for randomization. Results: The mean age of participants ranged between 51 and 57 years with an HD duration of 9-11.2 months. Bodily pain score and general health score significantly increased in the Pom group and Pom+ Vit E group. The emotional role functioning score of the Pom+Vit E group was significantly higher than that of the placebo group (P<0.05). Conclusion: The consumption of PPE and Vit E had beneficial effects on mental components but not the physical components of QOL. Moreover, combination therapy was more effective than single therapy.

APA, Harvard, Vancouver, ISO, and other styles

50

Nyffenegger, Naja, Anna Flace, Cédric Doucerain, Franz Dürrenberger, and Vania Manolova. "The Oral Ferroportin Inhibitor VIT-2763 Improves Erythropoiesis without Interfering with Iron Chelation Therapy in a Mouse Model of β-Thalassemia." International Journal of Molecular Sciences 22, no. 2 (January 16, 2021): 873. http://dx.doi.org/10.3390/ijms22020873.

Full text

Abstract:

In β-thalassemia, ineffective erythropoiesis leads to anemia and systemic iron overload. The management of iron overload by chelation therapy is a standard of care. However, iron chelation does not improve the ineffective erythropoiesis. We recently showed that the oral ferroportin inhibitor VIT-2763 ameliorates anemia and erythropoiesis in the Hbbth3/+ mouse model of β-thalassemia. In this study, we investigated whether concurrent use of the iron chelator deferasirox (DFX) and the ferroportin inhibitor VIT-2763 causes any pharmacodynamic interactions in the Hbbth3/+ mouse model of β-thalassemia. Mice were treated with VIT-2763 or DFX alone or with the combination of both drugs once daily for three weeks. VIT-2763 alone or in combination with DFX improved anemia and erythropoiesis. VIT-2763 alone decreased serum iron and transferrin saturation (TSAT) but was not able to reduce the liver iron concentration. While DFX alone had no effect on TSAT and erythropoiesis, it significantly reduced the liver iron concentration alone and in the presence of VIT-2763. Our results clearly show that VIT-2763 does not interfere with the iron chelation efficacy of DFX. Furthermore, VIT-2763 retains its beneficial effects on improving ineffective erythropoiesis when combined with DFX in the Hbbth3/+ mouse model. In conclusion, co-administration of the oral ferroportin inhibitor VIT-2763 and the iron chelator DFX is feasible and might offer an opportunity to improve both ineffective erythropoiesis and iron overload in β-thalassemia.

APA, Harvard, Vancouver, ISO, and other styles

Journal articles on the topic 'VIT'

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles