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Journal articles on the topic 'Vinica'

Author: Grafiati

Published: 28 June 2021

Last updated: 18 February 2022

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1

Pascuttini-Juraga, Vesna. "Kulturna baština Općine Vinica." Kaj 51, no. 5-6 (2018): 83–97. http://dx.doi.org/10.32004/k.51.5-6.1.

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Područje Općine Vinica karakterizira bogata povijest s mnoštvom očuvane kulturne i prirodne baštine, a cilj ovog rada je predstaviti ove bogate kulturne slojeve kao i sudjelovanje Općine Vinica u projektu „Ruralna detoksikacija upoznavanjem bogatstva kulturne baštine DETOX SLO-HR 98“ koji se provodi u okviru programa prekogranične suradnje INTERREG V-A Slovenija - Hrvatska 2014-2020. U srednjovjekovnom razdoblju Vinica je bila važno trgovište s utvrdom castrum Vinica koja se spominje u 14. stoljeću i crkvom svetog Marka. Na području Općine Vinica u kasnijim je razdobljima izgrađeno nekoliko dvoraca, kurija te drugih građevina svjetovnog karaktera. Među njima se ističu ostatci dvorca Opeka, oko kojeg nastaje i vrijedan perivoj danas poznat kao arboretum Opeka. Značajne građevine su: kurija Patačić, kurija Mattačić-Dolansky, kurija Köröskeny-Rupčić te dvorac Bajnski Dvori s perivojem i kapelicom. Posebno je vrijedan kameni spomenik „Pranger“ nekadašnja mjera za žito i sramotni kamen, jedinstveni takav primjer očuvan na području sjeverozapadne Hrvatske. Od očuvane baštine viničkog kraja valja spomenuti barokni pil sv. Benedikta te barokni zdenac s kipom sv. Ivana Nepomuka. Tradicijska graditeljska baština na području Općine Vinica obilježena je očuvanim stambenim i gospodarskim građevinama koje su građene od kamena vinicita. Kamen vinicit vadio se u prošlosti, a također se vadi još i danas u kamenolomu Marčan na području Općine Vinica. Većina stambenih i gospodarskih građevina ovoga kraja građena je upravo od kamena vinicita. U sklopu INTERREG Programa DETOX SLO-HR 98 kao jedan od partnera sudjelovala je Općina Vinica. Na području Općine Vinica kroz ovaj je program obnovljena i uređena tradicijska vinička kuća građena od kamena vinicita, izrađena je replika nekadašnjeg viničkog sramotnog stupa i kamene mjere tzv. Prangera te je obnovljen barokni kip sv. Ivana Nepomuka.

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2

D, Rajmohan, Saranya D, Logankumar K, Ranjithkumar R, and Chandrashekar B. "BIOMIMETIC SYNTHESIS AND CHARACTERIZATION OF SILVER NANOPARTICLES (AGNPS) USING VINCA ROSEA AQUEOUS EXTRACT." Kongunadu Research Journal 2, no. 2 (November 4, 2019): 1–5. http://dx.doi.org/10.26524/krj85.

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Biomimetic route for the synthesis of silver nanopartilces with using biological source play a very important role in nanotechnology without any harmful chemical. The present study deals with the synthesis of silver nanopartilces by treating silver nitrate with aqueous extract Vinca rosea at room temperature. Theeffect of the Vinica rosea aqueous extract on the formation of silver nanopartilces was characterized by UVvisible spectroscopy (UV-Vis), X-ray Diffraction Spectrum (XRD), Scanning Electron Microscopy (SEM) and Energy Dispersive X-ray Analysis (EDX). The UV spectra results show a strong resonance centre and surfaceof silver nanopartilces (AgNPs) at 461 nm. XRD and SEM studies revealed that the synthesized AgNPs shows spherical in shape with average particles size around 30- 70 nm.

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3

Mansour, Nermin Maher, Nancy Hassan Aboelnour, Fady Samy Faltaous, and Mohamed Maher Elkabalawy. "Effect of Vinica Alkaloids Iontophoresis on Post-Mastectomy Shoulder Pain." Egyptian Journal of Hospital Medicine 82, no. 3 (January 1, 2021): 562–66. http://dx.doi.org/10.21608/ejhm.2021.148559.

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4

Tanevska, Vinka, Igor Kuzmanovski, and Orhideja Grupče. "Provenance Determination of Vinica Terra Cotta Icons Using Self-Organising Maps." Annali di Chimica 97, no. 7 (June 2007): 541–52. http://dx.doi.org/10.1002/adic.200790036.

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5

Manaskova, Magdalena. "Archaeological Site’s Utilization and Popularization — The Case of the Archaeological Site Kale Vinica." Arheologija i prirodne nauke 8 (2012): 69–76. http://dx.doi.org/10.18485/arhe_apn.2012.8.5.

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6

�IMANSK�, VLADIM�R, and Otto LO�EK. "FERTILIZATION OF VINE BY A 5-AMINOLEVULINIC ACID-BASED FERTILIZER AND ITS PROFITABILITY." Journal of Central European Agriculture 14, no. 1 (2013): 270–83. http://dx.doi.org/10.5513/jcea01/14.1.1195.

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7

Goss, Vladimir P., and Vjekoslav Jukić. "Rural Romanesque and a Europe without Borders. The Case of St. Mark's Church in Vinica." Hortus Artium Medievalium 14 (January 2008): 133–40. http://dx.doi.org/10.1484/j.ham.2.305444.

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8

Zhu, Jihe, Blagica Arsovska, and Kristina Kozovska. "STATISTICAL DATA FOR CERVICAL CANCER SCREENING FROM 2016 – 2020 AND AMBULATORY AND DISPENSARY MORBIDITY FROM 2011 – 2020 FOR KOCANI, VINICA, BEROVO, PEHCEVO AND DELCEVO." International Journal of Research -GRANTHAALAYAH 9, no. 8 (September 3, 2021): 246–57. http://dx.doi.org/10.29121/granthaalayah.v9.i8.2021.4185.

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Each year, more than half a million women are diagnosed with cervical cancer, resulting in about 300,000 deaths a year. In Macedonia cervical cancer is second most common according to the prevalence of malignant neoplasms in women. The most common and most studied cause is Human Papillomavirus (HPV). For the research were used statistical materials obtained from Center for Public Health – Kocani and State Statistical Office of R. Northern Macedonia. For the collected data from the organized screening on the territory of Kocani, Vinica, Berovo, Pehchevo and Delchevo for the period 2016-2020, as well as reported outpatient polyclinic morbidity for the same territory in a period of 10 years, ie from 2011 – 2020, was used statistical method. Screening with Pap smear is the best method to decrease the number of cervical cancer diseased and decrease mortality. Preliminary results from new immunotherapy approaches show promising results for overall survival. The main purpose of this research is to point out the importance of regular examinations and screening for early detection of cervical changes, prevention of invasive forms of cancer, and timely treatment.

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9

Woodward, J. E., M. R. Vandiver, K. L. Ong, and S. A. McBride. "First Report of Vinca minor Co-infected with Puccinia vincae and Golovinomyces orontii in Texas." Plant Health Progress 13, no. 1 (January 2012): 39. http://dx.doi.org/10.1094/php-2012-0724-01-br.

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Vinca spp. are commonly planted in gardens and landscapes as a groundcover. In May 2009, diseased periwinkle (Vinca minor L.) plants were obtained from an established residential landscape in Muleshoe, TX. Both Golovinomyces orontii (Castagne) V.P. Heluta and Puccinia vincae were identified as pathogens in the samples. Whereas both G. orontii and P. vincae have been reported on Vinca minor in the United States, this is the first report of each in Texas. Accepted for publication 24 May 2012. Published 24 July 2012.

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10

Hernández, J. R., M. E. Palm Hernández, and T. Tidwell. "First Report of Puccinia vincae on Vinca spp. in California." Plant Disease 86, no. 1 (January 2002): 75. http://dx.doi.org/10.1094/pdis.2002.86.1.75b.

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In 2000, chlorotic leaves with inconspicuous leaf spots were observed on several Vinca major L. and V. minor L. plants in a 0.8-ha area in Woodside, CA. In August 2001, 80 to 90% of the plants were symptomatic. Uredinia measuring 2 to 3 × 1 mm were present on the lower surface of leaves. Urediniospores were ellipsoidal to oblong, 27 to 36 × 17 to 27 μm, with cinnamon-brown walls 1 to 2 μm thick, echinulate, and with three or four equatorial or slightly supraequatorial germ pores. Telia were produced in the uredinia. Teliospores were 1-septate, ellipsoidal to clavate, slightly constricted at the septum, and 34 to 45 × 19 to 30 μm. Teliospore walls were chestnut brown, 1.5 to 2.5 μm thick, and verrucose, with the verrucae sometimes in longitudinal lines. One germ pore covered by a hyaline papilla was present in each cell, at the apex in the upper cell and adjacent to the short, hyaline pedicel in the lower cell. The rust was identified as Puccinia vincae Berk. (1). P. vincae is widespread in Europe on Vinca species and is common on V. major in the eastern United States, Washington, and Idaho (2). To our knowledge, this is the first report of P. vincae on V. major in California (vouchers BPI 841363, 841364) and on V. minor in the United States (voucher BPI 841365). References: (1) J. C. Arthur. Page 324 in: Manual of Rusts in the United States and Canada. Purdue Research Foundation, Lafayette, IN, 1934. (2) D. F. Farr et al. Pages 35 and 916 in: Fungi on Plants and Plant Products in the United States. American Phytopathological Society, St. Paul, MN, 1989.

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11

&NA;. "Vinca alkaloids." Reactions Weekly &NA;, no. 1138 (February 2007): 27. http://dx.doi.org/10.2165/00128415-200711380-00080.

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12

Nithyanandham Masilamani and Dhanraj Ganapathy. "Awareness of Vinca alkaloids among dental students." International Journal of Research in Pharmaceutical Sciences 11, SPL3 (September 18, 2020): 911–14. http://dx.doi.org/10.26452/ijrps.v11ispl3.3048.

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Vincristine along with vinblastine are dual indole-based conjugated Vinca alkaloids formed from foliage of the herb Catharanthusroseus, traditionally known as Vincarosea vincristine , that have been effectively prescribed as single treatment and also in conjunction with other medications in hematological and stable malignancies chemotherapy for tumors. The purpose of this survey was to assess awareness of medical use of vinca alkaloids among dental undergraduate students. A cross-section study was performed with a self-directed survey questionnaire containing 10 queries distributed among 100 dental students. The questionnaire assessed the awareness about vinca alkaloids, their medicinal uses, anticancer activity, mechanism of action and side effects. The responses were recorded and analysed.94% of the respondents were not aware of medical uses of vinca alkaloids.95% were not aware of anticancer activity of vinca alkaloids.97 % were not aware of the mechanisms of action of vinca alkaloids. Again 97% were not aware of side effects of the vinca alkaloids. This study concluded the awareness about the medical use of vinca alkaloids among dental students was poor. Majority of them are not aware of the anticancer activity of vinca alkaloids.

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13

Hürter, Johannes, and Matthias Uhl. "Hitler in Vinnica." Vierteljahrshefte für Zeitgeschichte 63, no. 4 (October 15, 2015): 581–640. http://dx.doi.org/10.1515/vfzg-2015-0035.

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Vorspann Die Nerven lagen blank in Vinnica. Dort, in der Ukraine, hatte Adolf Hitler im Sommer 1942 sein Hauptquartier aufgeschlagen, und von dort aus musste er mitansehen, wie der zweite große Feldzug in der Sowjetunion, der Griff nach dem kaukasischen Öl, scheiterte. Als sich die deutsche Offensive im September 1942 endgültig festlief, schwanden die deutschen Erfolgsaussichten nahezu vollständig, bereits Monate vor der Niederlage in Stalingrad. Die Enttäuschung eskalierte in heftigen Schuldzuweisungen Hitlers an seine Generale. Bisher war man über diesen Konflikt nur aus der Sicht der Generalität informiert. Jetzt ist in einem russischen Archiv das Wortprotokoll einer vertraulichen Besprechung Hitlers mit Keitel aufgetaucht, das die Meinungen und Stimmungen des Diktators an der Peripetie des Kriegsjahrs 1942 unmittelbar wiedergibt.

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14

Bahadori, Fatemeh, Gülaçtι Topçu, Mehmet Boǧa, Ayla Türkekul, Ufuk Kolak, and Murat Kartal. "Indole Alkaloids from Vinca major and V. minor Growing in Turkey." Natural Product Communications 7, no. 6 (June 2012): 1934578X1200700. http://dx.doi.org/10.1177/1934578x1200700610.

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A new indole alkaloid, 11-hydroxypolyneuridine, was isolated from Vinca major subsp. major L. and the known indole alkaloids vallesiachotamine and isovallesiachotamine from Vinca minor L. This is the first report on the alkaloids of both Vinca species growing in Turkey; vallesiachotamine and isovallesiachotamine were isolated from a Vinca species for the first time. V. minor may be considered as a new source for these two alkaloids due to their occurrence in high amount in the aerial parts of the plant. The alkaloid extracts of the two Vinca species were found to have high lipid peroxidation inhibitory and DPPH radical scavenging activities. Anticholinesterase activity of the extracts was also very strong.

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15

Anderson, Jeffrey A., and Sonali R. Padhye. "Protein Aggregation, Radical Scavenging Capacity, and Stability of Hydrogen Peroxide Defense Systems in Heat-stressed Vinca and Sweet Pea Leaves." Journal of the American Society for Horticultural Science 129, no. 1 (January 2004): 54–59. http://dx.doi.org/10.21273/jashs.129.1.0054.

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Although heat stress injury is known to be associated with membrane dysfunctions, protein structural changes, and reactions of activated forms of oxygen, the underlying mechanisms involved are poorly understood. In this study, the relationships between thermotolerance and hydrogen peroxide (H2O2) defense systems, radical scavenging capacity [based on 1,1-diphenyl-2-picrylhydrazyl (DPPH) reduction], and protein aggregation were examined in vinca [Catharanthus roseus (L.) G. Don `Little Bright Eye'], a heat tolerant plant, and sweet pea (Lathyrus odoratus L. `Explorer Mix'), a heat susceptible plant. Vinca leaves were 5.5 °C more thermotolerant than sweet pea leaves based on electrolyte leakage analysis. Vinca leaf extracts were more resistant to protein aggregation at high temperatures than sweet pea leaf extracts, with precipitates forming at ≥40 °C in sweet pea and at ≥46 °C in vinca. Vinca leaves also had nearly three times greater DPPH radical scavenging capacity than sweet pea leaf extracts. Two enzymatic detoxifiers of H2O2, catalase (CAT) and ascorbate peroxidase (APOX), demonstrated greater activities in vinca leaves than in sweet pea leaves. In addition, CAT and APOX were more thermostable in vinca, compared with sweet pea leaves. However, tissue H2O2 levels did not differ between controls and tissues injured or killed by heat stress in either species, suggesting that H2O2 did not play a direct role in acute heat stress injury in vinca or sweet pea leaves. Greater thermotolerance in vinca, compared with sweet pea, was associated with greater DPPH radical scavenging capacity, indicating that AOS other than H2O2 may be involved in acute heat stress injury.

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16

O'Marcaigh, Aengus S., and Donna L. Betcher. "The Vinca Alkaloids." Journal of Pediatric Oncology Nursing 12, no. 3 (January 1995): 140–42. http://dx.doi.org/10.1177/104345429501200310.

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17

OMARCAIGH, A. "The vinca alkaloids." Journal of Pediatric Oncology Nursing 12, no. 3 (July 1995): 140–42. http://dx.doi.org/10.1016/1043-4542(95)90107-8.

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18

Abdulmyanova, L. I., D. M. Ruzieva, R. S. Sattarova, and T. G. Gulyamova. "Vinca alkaloids Produced by Endophytic Fungi Isolated from Vinca plants." International Journal of Current Microbiology and Applied Sciences 7, no. 06 (June 10, 2018): 2244–50. http://dx.doi.org/10.20546/ijcmas.2018.706.267.

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19

Abdulmyanova, L. I., D. M. Ruzieva, R. S. Sattarova, and T. G. Gulyamova. "Vinca Alkaloids Produced by Endophytic Fungi Isolated from Vinca Plants." International Journal of Current Microbiology and Applied Sciences 7, no. 07 (July 10, 2018): 4142–47. http://dx.doi.org/10.20546/ijcmas.2018.707.483.

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20

Palmisano, Giovanni, Sergio Crippa, Bruno Danieli, Giordano Lesma, Daniele Passarella, and Vittorio Vecchietti. "Indole Alkaloids from Vinca sardoa, a New Species of Vinca." HETEROCYCLES 31, no. 9 (1990): 1663. http://dx.doi.org/10.3987/com-90-5480.

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21

Nemali, Krishna, and Marc W. van Iersel. "Relating Whole-plant Photosynthesis to Physiological Acclimations at Leaf and Cellular Scales under Drought Stress in Bedding Plants." Journal of the American Society for Horticultural Science 144, no. 3 (May 2019): 201–8. http://dx.doi.org/10.21273/jashs04665-19.

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Bedding plants are at increased risk for exposure to drought stress during production because they are grown in small containers. Physiological mechanisms of bedding plants at leaf and cellular scales that regulate whole-plant photosynthesis under drought conditions are not well understood. This information can be useful for screening bedding plant cultivars with improved drought-tolerance and generate guidelines to mitigate drought stress during production. We subjected drought-sensitive salvia (Salvia splendens ‘Bonfire Red’) and drought-tolerant vinca (Catharanthus roseus ‘Cooler Peppermint’) to gradual drought stress inside whole-plant gas exchange chambers. Substrate water content (Θ), whole-plant net photosynthesis (Pn_avg), whole-plant respiration (Rd_avg), and daily carbon gain (DCG) were measured continuously, whereas stomatal conductance (gS) to water, leaf water (ΨL), osmotic (ΨS), and turgor (ΨP) potentials were measured at the start and end of the drought phase. In addition, ΨS was measured before exposure to stress and after thoroughly rehydrating plants. Dark-adapted quantum efficiency (dark-adapted ΦPSII) was measured after rehydrating plants. The results indicated that, at whole-plant scale, vinca continued to uptake water at lower Θ levels than the Θ level that resulted in wilting of salvia. There were no differences in Rd_avg; however, Pn_avg and DCG of salvia decreased at a higher Θ level than that of vinca. This indicated that salvia experienced drought stress at a higher Θ level than did vinca. At the leaf scale, there were no differences in ΨL; however, a more negative ΨS (P = 0.06) and significantly higher ΨP were observed in vinca (compared to salvia) under drought conditions. In addition, ΨS was not different between species before exposure to drought, whereas ΨS of rehydrated leaves after exposure to drought in vinca was significantly lower than that in salvia. Moreover, ΨS of rehydrated leaves after exposure to drought was significantly lower than that observed before exposure to drought in vinca. This indicated osmotic adjustment (OA) in vinca under drought conditions. Dark-adapted ΦPSII was lower in salvia than in vinca after exposure to drought, indicating damage to photosynthetic mechanisms. Our results suggested that increased OA likely helped to maintain higher ΨP under drought conditions and continuation of water uptake at lower Θ in vinca compared to salvia. In addition, healthier photosynthetic mechanisms of vinca (compared to salvia) under drought conditions likely resulted in its higher Pn_avg and DCG at lower Θ. Screening for OA and dark-adapted ΦPSII may be useful for developing drought-tolerant bedding plant cultivars.

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22

Antonovic, Dragana, Kristina Resimic-Saric, and Vladica Cvetkovic. "Stone raw materials in the Vinca culture: Petrographic analysis of assemblage from Vinca and Belovode." Starinar, no. 55 (2005): 53–66. http://dx.doi.org/10.2298/sta0555053a.

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This paper shows the results of petrographic analyses of raw materials used for making the ground stone industry implements in two Vinca culture sites Vinca and Belovode. The assemblages from the aforementioned sites feature a number of specific characteristics. In Vinca, in late strata, a kind of devaluation in the selection of stone raw materials is registered, which is closely related to the decline in quality of stone processing and may be a consequence of territorial narrowing of the Vinca culture per se in its later phases, and of introduction of metallurgy in everyday life. For this reason an analogy with the Belovode site was made, which subsists only throughout the early phase of the Vinca culture and is doubtlessly a metallurgic settlement. Petrographic analyses of the raw materials from which ground stone tools used to be made at the Vinca and Belovode sites are only a part of the commenced petro-archaeological research. They imply that further investigations should focuses on field work, principally in the vicinity of the sites themselves. Primarily by petrographic, and, as applicable, by other analyses of samples brought from the field work, and by comparison of the tools, it could be possible to define more precisely the territory from which the raw materials originated.

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23

Nikolic, Dubravka, and Jasna Vukovic. "Vinca ritual vessels: Archaeological context and possible meaning." Starinar, no. 58 (2008): 51–69. http://dx.doi.org/10.2298/sta0858051n.

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The Hyde-vase and anthropomorphic vessel found at Vinca within two sets of pottery vessels are vessels of cult the meaning of which has never been examined. The authors highlight the significance of their archaeological contexts and positions in the settlement, reconstructed based on the preserved documents. The cult character of both pottery sets is confirmed and they are thought to have been used for a ritual important to the whole Vinca community. Considering that they come from the horizon associated with the beginning of the Gradac phase of the Vinca culture, the performed ritual may be seen as a possible reaction of the Vinca inhabitants to dynamic changes triggered by emergence of metallurgy in the region and the whole of South East Europe.

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24

Hoelzer, Karen L., Bruce R. Harrison, Susan W. Luedke, and Dan W. Luedke. "Vinblastine-Associated Pulmonary Toxicity in Patients Receiving Combination Therapy with Mitomycin and Cisplatin." Drug Intelligence & Clinical Pharmacy 20, no. 4 (April 1986): 287–89. http://dx.doi.org/10.1177/106002808602000415.

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Two of 33 patients entered in a local pilot study of mitomycin, vinblastine, and cisplatin for non-small cell lung cancer developed vinblastine-associated pulmonary toxicity. As with other reports of vinca alkaloid-related pulmonary toxicity, the regimen included mitomycin. Based on these cases and others previously reported, the incidence of abrupt pulmonary toxicity following vinca alkaloid administration as part of mitomycin/vinca alkaloid combination appears to be three to six percent. Suggestions for management are given.

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Ekaputri, Rahmawati, Sudarsono Sudarsono, and Budi Mulyaningsih. "Larvicidal Effect of Vinca Fruit Extract (Vinca rosea) Against Aedes aegypti Larvae and Secondary Metabolites Profile by Thin Layer Chromatography." Biology, Medicine, & Natural Product Chemistry 3, no. 1 (April 1, 2014): 31. http://dx.doi.org/10.14421/biomedich.2014.31.31-33.

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<p>Background: <em>Vinca rosea</em> is known contain alkaloids, it was usually used to treat various diseases. Alkaloids from Vinca leaves are also already known have larvicidal activity. Based on this toxicological activity, the fruit of <em>Vinca rosea</em> was selected to investigation its larvicidal activity against the 3<sup>rd</sup> instar larvae of the mosquito vector of dengue haemorrhagic fever (DHF) <em>Aedes aegypti.</em> Five concentrations of Vinca fruit extract were tested against the 3<sup>rd</sup> instar Aedes aegypti larvae. The different larval mortality percentages were recorded after 24 hours. Lethal concentration (LC<sub>50</sub> anf LC<sub>90</sub>) of Vinca fruit extract were calculated using Probit analysis. Phytochemical compounds of ethanolic extract also investigated using Thin layer Chromatography (TLC). LC<sub>50</sub> and LC<sub>90</sub> values of fruit extract were 2.987 mg/ml and 32.861 mg/ml. Alkaloids were detected in extract.</p>

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26

SUKARMAN, SUKARMAN, I. DARWATI, and D. RUSMiN. "KARAKTER MORFOLOGI DAN FISIOLOGI TAPAK DARA (Vinca rosea L.) PADA BEBERAPA CEKAMAN AIR." Jurnal Penelitian Tanaman Industri 6, no. 2 (July 15, 2020): 50. http://dx.doi.org/10.21082/jlittri.v6n2.2000.50-54.

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<p><strong>Morphological and physiological characteristics of Vinca at di fferent water stress levels</strong></p><p>Vinca (Vinca rosea L.) is one of the important medicinal crops as the sources of raw materials for traditional medicines. Its alkaloid is believed can reduce the risk of cancer, blood tension and diabetes diseases. Recently, vinca is only grown as ornamental plant in the garden, therefore, its cultivation methods is limited, especially its water stress tolerance, lite purpose of this experiment was to study the effect of water stess on the morphological and physiological characteristics of vinca. A pot experiment was conducted in the plastics house of the Research Institute for Spice and Medicinal Crops from November 1997 to March 1998. Factorial experiment consisted two factors and three replications was arranged in a randomized block design. Ihe irst factor consisted of two vinca varieties, those wee white flowers (WFV) and red flowers of vinca (RFV). While 4 different levels of water stress i.e., (I) 100% ield capacity (FC), (2) 80% FC, (3) 60% FC, and (4) 40% FC were used as the second factor. Parameters used for evaluating the effect of teatment consisted of morphological characteristics such as (I) plant height, (2) number of primary branches, (3) number of leaves, (4) leaf area (5) dry weight of stem, (6) dry weight of leaf, (7) dry weight of flowers and (8) dry weight of roots, and physiological characteristics observed including: (I) percentages of opened stomata and (2) free proline content of leaf. Results showed that interaction between varieties and water stress did not significantly affect the morphological nor physiological characteristics. Varieties significantly affected the morphological characteristics (except plant height), however they did not signiicantly affect physiological characteristics. Water stress significantly affected the morphological (except dry weight of roots) and free proline contents. Under 80% FC, vinca produced the highest growth and dry weight of plant however, the plant growth and dry weight wee inhibited under 60 and 40% FC. Under 40% FC, percentages of opened stomata deceased signiicantly. Moeover, proline content in the leaves signiicantly increased by water stess treatments.</p>

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27

Spasic, Milos, and Adam Crnobrnja. "Vinca bowls with protoma." Starinar, no. 64 (2014): 185–203. http://dx.doi.org/10.2298/sta1464185s.

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Bowls with protoma represent one of several tens of types of Vinca vessels made of baked clay which have been published as finds excavated at Vinca sites for more than a century. We are dealing here with bowls of a markedly conical profile, with angled and slightly rounded walls and with a flat or slightly annular bottom. In most cases these bowls are not decorated, with the exception of the rare finds decorated by fluting, engraving and polishing. Their most significant peculiarity is the presence of four or eight protoma on the rim, facing the inside of the vessel. Taking into consideration all stylistic-typological characteristics, it is possible to divide them into two coherent categories of finds. The first consists of bowls with four oppositely placed protoma. Within this group it is possible to single out two subtypes, bowls with all four as anthropomorphic (Pl. I/6, 7; Pl. III/34) or all four as zoomorphic representations (Pl. I/5, 8, 9; Pl. III/33, 36). Bowls with eight protoma have actually got four pairs of oppositely placed representations. It was possible to discern two subtypes based on the objects that were completely preserved. The first subtype includes a bowl from the so-called Vinca ritual set, with two pairs of zoomorphic and two pairs of anthropomorphic protoma, both oppositely placed (Pl. I/3). The second subtype includes a bowl from house 1/2010 from Stubline with four identical, paired, totally stylised and schematised representations, whose identification is impossible (Fig. 1; Pl. I/1). Taking into consideration the metric and technological data, the thesis that seems most possible is that the bowls with protoma served for the consumption of or the storing/displaying of the content during some quite specific activities. Bowls with protoma appear in almost all regions of the central Balkans populated by Vinca culture communities and we do not note them in the areas of the neighbouring Late Neolithic communities. These bowls appear in a very long and clearly defined time span and their usage lasts for exactly the same time as the Vinca culture itself, appearing at the same time and together disappearing. The first vessels with their protoma facing the inside, appear almost synchronously at the very beginning of the Vinca culture, that is the Late Neolithic of the Balkans, in the centre of its area (Vinca and Grivac), but also in its furthermost peripheral areas (R?szke-L?dv?r and Anza). Such a long period of almost 700 hundred years, in which one complex iconographic pattern survives without any significant changes (with the exception of the stylistic characteristics of the protoma themselves), primarily points to a long-standing and unchanged custom/belief/ritual that can evidently be associated solely with the communities within the Vinca culture. It is important to highlight the fact that bowls with protoma show ?canonic? consistency to the utmost degree, even more so than the concurrent sacrificial alters and prosopomorphic lids. Dare we assume, on the basis of all that has been said, that in front of us we have a clearly canonised material pattern through which a clearly defined way of thinking/beliefs of one distinct community can be sensed? Their abrupt disappearance, together with the disappearance of the Vinca culture, that is to say the Late Neolithic way of living, should not be surprising. The change that comes along with the abandonment of the last Vinca settlements is not only perceptible in the material culture, but also, and above all, in the social system and the organisation of the community. Fundamental changes in the social structure in the middle of the 5th millennium BC, evidently led to the downfall and disappearance of many deep-rooted values of the communities of that time, as well as the very system of beliefs and sagas. This resulted in the disappearance of the vessels with protoma?s utilisation, one of the most steadfast material manifestations of the Vinca culture.

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Atta-Ur-Rahman, Abida Sultana, Farzana Nighat, M. Khalid Bhatti, Semra Kurucu, and Murat Kartal. "Alkaloids from Vinca major." Phytochemistry 38, no. 4 (March 1995): 1057–61. http://dx.doi.org/10.1016/0031-9422(94)00638-a.

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Ciorîță, Alexandra, Septimiu Cassian Tripon, Ioan Gabriel Mircea, Dorina Podar, Lucian Barbu-Tudoran, Cristina Mircea, and Marcel Pârvu. "The Morphological and Anatomical Traits of the Leaf in Representative Vinca Species Observed on Indoor- and Outdoor-Grown Plants." Plants 10, no. 4 (March 24, 2021): 622. http://dx.doi.org/10.3390/plants10040622.

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Morphological and anatomical traits of the Vinca leaf were examined using microscopy techniques. Outdoor Vinca minor and V. herbacea plants and greenhouse cultivated V. major and V. major var. variegata plants had interspecific variations. All Vinca species leaves are hypostomatic. However, except for V. minor leaf, few stomata were also present on the upper epidermis. V. minor leaf had the highest stomatal index and V. major had the lowest, while the distribution of trichomes on the upper epidermis was species-specific. Differentiated palisade and spongy parenchyma tissues were present in all Vinca species’ leaves. However, V. minor and V. herbacea leaves had a more organized anatomical aspect, compared to V. major and V. major var. variegata leaves. Additionally, as a novelty, the cellular to intercellular space ratio of the Vinca leaf’s mesophyll was revealed herein with the help of computational analysis. Lipid droplets of different sizes and aspects were localized in the spongy parenchyma cells. Ultrastructural characteristics of the cuticle and its epicuticular waxes were described for the first time. Moreover, thick layers of cutin seemed to be characteristic of the outdoor plants only. This could be an adaptation to the unpredictable environmental conditions, but nevertheless, it might influence the chemical composition of plants.

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Poorani, V., Vigneswaran, and G. Venkat Kumar. "Nano-Niosomal Formulation of Alkaloids from Vinca rosea for Improved Oral Delivery." Journal of Pharmaceutical and Medicinal Research 5, no. 1 (December 14, 2020): 102–5. http://dx.doi.org/10.30799/jpmr.052.20050105.

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Phytochemicals, the natural biochemical substances produced by plants possess a range of medicinal values. These phytochemicals get into our system through food and bring different physiological benefits. However, many of these phytochemicals lack essential physicochemical properties that can provide them effective drug-likeness properties. Vinca rosea alkaloids are known for their therapeutic values especially in the cancer treatment domain. However, the physiochemical properties of these molecules limit their bioavailability greatly. This current research aimed at improving the bioavailability of Vinca rosea alkaloids through the nanovector system, niosomes. Vinca alkaloids were extracted, purified, screened and quantified. Niosomal constructs of the alkaloids were made, characterized through scanning electron microscope and ex-vivo studies were carried out using goat intestine. The size of the niosomes was found to be in the range of 400 to 800 nm. Results shows that niosomal formulation can increase bioavailability of Vinca rosea alkaloids two folds compared to the native alkaloid extract.

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Spasic, Milos. "Vinca-Belo Brdo: Vernissages of eneolithic belgrade and its vicinity I." Starinar, no. 59 (2009): 27–51. http://dx.doi.org/10.2298/sta0959027s.

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The following paper will discuss the problems of Eneolithic settlements of Baden and Kostolac culture at Vinca near Belgrade. Eneolithic horizons from Vinca site were scarcely published owing to the fact that both Baden and Kostolac layers are not well stratified because of heavy medieval devastations. In spite of all post-depositional destructions Eneolithic settlements at Vinca show enormous significance for understanding the life of the period, both on the micro and macro-regional scale. At the same time, this work is a sort of an insight into the results of ongoing analysis of material culture and socio-economic patterns of Eneolithic period settlements in Belgrade and its vicinity.

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Porcic, Marko. "De facto refuse or structured deposition? House inventories of the late neolithic Vinca culture." Starinar, no. 62 (2012): 19–43. http://dx.doi.org/10.2298/sta1262019p.

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The goal of this paper is to determine whether there are reasons to believe that inventories from the Late Neolithic Vinca culture houses do not represent systemic assemblages and to offer an interpretation of household assemblage variation. Pottery inventories from Vinca culture houses were compared to the ethnographically recorded range of variation in household inventory size. The discard equation was used to make projections of the accumulated assemblages from house assemblages for comparison with empirically observed accumulated assemblages. It is concluded that in general there is no reason to reject the assumption that Vinca household inventories reflect systemic assemblages. Moreover, the patterns of inventory variability can be meaningfully interpreted in social terms.

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Gutowski, Magda C., Daniel V. Fix, Jose R. Corvalan, and David A. Johnson. "Reduction of Toxicity of a Vinca Alkaloid by an Anti-Vinca Alkaloid Antibody." Cancer Investigation 13, no. 4 (January 1995): 370–74. http://dx.doi.org/10.3109/07357909509031917.

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Zhang, Dangquan, and Arun Kanakkanthara. "Beyond the Paclitaxel and Vinca Alkaloids: Next Generation of Plant-Derived Microtubule-Targeting Agents with Potential Anticancer Activity." Cancers 12, no. 7 (June 29, 2020): 1721. http://dx.doi.org/10.3390/cancers12071721.

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Plants are an important source of chemically diverse natural products that target microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel, and vinca alkaloids are the earliest plant-derived microtubule-targeting agents (MTAs), and paclitaxel and vinca alkaloids are currently important drugs used in the treatment of cancer. Several additional plant-derived compounds that act on microtubules with improved anticancer activity are at varying stages of development. Here, we move beyond the well-discussed paclitaxel and vinca alkaloids to present other promising plant-derived MTAs with potential for development as anticancer agents. Various biological and biochemical aspects are discussed. We hope that the review will provide guidance for further exploration and identification of more effective, novel MTAs derived from plant sources.

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Thomas, Paul A., and Joyce G. Latimer. "FORM OF NITROGEN AFFECTS GROWTH OF CATHARANTHUS ROSEUS." HortScience 31, no. 5 (September 1996): 752c—752. http://dx.doi.org/10.21273/hortsci.31.5.752c.

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Annual vinca [Catharanthus roseus (L.) G. Don] is intolerant of high fertility, cool temperatures, and wet soil conditions, making vinca difficult for growers to produce alongside other, more tolerant bedding plants. Our objective was to develop better recommendations for producers. Growth of `Grape Cooler' vinca was compared using different production inputs, including type of media (with or without bark), form of micronutrient source, and form of N. Optimal root and shoot dry weights occurred in peat-lite media with either sulfated or chelated micronutrients adjusted to pH 5.5. Root and shoot dry weights were greatest when high nitrate-N to ammonium-N ratio fertilizers were used. Root and shoot dry weights were negatively affected by high levels of ammonium-N in the fertilizer solution. Root development is the critical factor in the production of high-quality vinca. Our data suggest that root development may be optimized by using fertilizer products that have a high nitrate to ammoniacal nitrogen ratio. Micronutrients in the sulfate form also seem to enhance growth when medium pH is maintained near 5.5. Use of high-porosity, peat-based mixes appears to provide an optimal root growth environment.

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Nemali*, Krishna, and Marc van Iersel. "Photosynthesis, Respiration, and Water Relations of Vinca and Salvia Subjected to Moisture Stress." HortScience 39, no. 4 (July 2004): 896B—896. http://dx.doi.org/10.21273/hortsci.39.4.896b.

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Subjecting bedding plants to non-lethal moisture stress is an established irrigation practice for bedding plants; however information on physiological responses of bedding plants to moisture stress is limited. We examined the CO2 exchange rates (CER) and water relations of salvia (Salvia splendens) and vinca (Catharanthus roseus) during moisture stress. Seedlings of both species were grown from seed in 7-L trays containing a soilless growing medium. After plants completely covered the trays, they were irrigated and shifted into whole-plant gas exchange chambers (27 °C and daily light integral of 7.5 mol/m2) arranged inside a growth chamber. Inside the gas exchange chambers, the growing medium was allowed to dry and plants were re-watered after wilting. Results from this study indicate that the growth rate (moles of CO2 gained by plants in a day) of salvia was higher than vinca before experiencing moisture stress; however the volumetric moisture content of the growing medium at which plant growth decreased was higher for salvia than for vinca. During moisture stress, the decrease in growth rate of salvia was gradual and that of vinca was rapid. After re-watering the plants, leaf water potential (ΨL) and growth rate of vinca revived completely, and ΨL of salvia remained low (more negative), whereas its growth rate revived completely. This study shows that bedding plant species respond differently to moisture stress, particularly with respect to the critical substrate moisture level for initiating moisture stress and the rate of development of moisture stress.

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Chen, Yan, Regina Bracy, and Allen Owings. "Planting Technique Matters in Reducing Vinca Disease in Landscapes." HortScience 41, no. 4 (July 2006): 1004D—1004. http://dx.doi.org/10.21273/hortsci.41.4.1004d.

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Annual vinca, Catharanthus roseus, is exceptionally adaptive to the summer heat and the sandy loam or clay soil in the southeastern region and provides season-long blooms once established in landscape plantings. A wide variety of colors, sizes, and applications are available for landscape use. However, diseases such as alternaria leaf spot and phytophthora leaf blight are prevalent in this region in vinca plantings. Effective disease control requires frequent fungicide application that is expensive and may pose negative effects on the environment. Proper planting techniques including date of planting, fertilization rate at planting, and variety selection may improve plant growth, reduce disease severity, and save landscape service business labor in disease management. Plants of three varieties: open-pollinated `Cooler Hot Rose', F1 hybrid `Titan Rose', and trailing variety `Mediterranean Lilac' were planted on 1 Apr. or 1 May in landscape plots. Plants were at the same growth stage at the time of planting and were fertilized with Osmocote 14–14–14 (3 months) at 0, 35, 70, or 140 g·m2. Plant growth index indicates that plant growth increased significantly at increasing fertilization rates; however, plant overall quality ratings were not significantly different among fertilized plants. Disease incidence in July suggests that late planting may reduce alternaria leaf spot in open-pollinated and hybrid upright type vinca. Disease severity in August was more pronounced on trailing vinca and more severe when plants were not fertilized or fertilized with the highest fertilization rate. Tissue analysis indicates that trailing vinca `Mediterranean Lilac' may require less fertilization than upright type.

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38

Douillard, J. Y., F. Fossela, V. Georgoulias, J. L. Pujol, K. Kubota, A. Monnier, K. Takeda, M. Cucherat, and S. Laporte. "Comparison of docetaxel and vinca alkaloid, alone or in combination with other chemotherapy agents, in the first-line treatment of advanced non-small cell lung cancer (NSCLC): A meta-analysis." Journal of Clinical Oncology 24, no. 18_suppl (June 20, 2006): 7034. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.7034.

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7034 Background: Taxanes and vinca alkaloids are commonly used agents, in first-line therapy of advanced NSCLC. As some data in comparative studies have suggested possible differences in survival and safety, we performed a meta-analysis in order to assess the potential benefit of docetaxel-based regimens in comparison with vinca alkaloid-based regimens, in terms of overall survival (OS) and toxicity. Methods: MEDLINE, CANCERLIT and Cochrane Library searches were supplemented by information from clinical study reports and by manual searching of relevant meeting proceedings. Only randomized trials comparing docetaxel-based chemotherapy to vinorelbine- or vindesine-based chemotherapy were included. Outcomes recorded were OS and neutropenia. Fixed-effects and random-effects models were used to estimate the pooled hazard ratio (HR) of OS and the odds ratio (OR) of neutropenia. A HR or OR less than 1 indicates that docetaxel is superior to vinca alkaloids. Heterogeneity was assessed using the Cochran Q-test. Results: The seven selected trials (six using vinorelbine as vinca alkaloid) yielded a total of 2,867 patients (docetaxel regimens: 1,638; vinca alkaloid regimens: 1,229). Docetaxel was combined with a platinum compound in three trials, with gemcitabine in two trials and used as monotherapy in two trials. The vinca alkaloid was combined with a platinum compound in six trials, and used alone (vinorelbine) in one. The pooled estimate of the OS shows a significant improvement in favor of docetaxel (HR=0.89, 95%CI [0.82;0.96], p=0.03), this benefit persisting after exclusion of the vindesine study (HR=0.90 [0.83;0.98]) and also after excluding monotherapy regimens (HR=0.89 [0.82;0.97]. While neutropenia was common, it was significantly less frequent with docetaxel (OR=0.60 [0.39;0.92], p=0.019), as was febrile neutropenia (OR=0.60 [0.39;0.96], p=0.034). Conclusions: The results of this meta-analysis support the superior efficacy (OS) and safety (neutropenia and febrile neutropenia) of docetaxel in first-line therapy of advanced NSCLC as compared with vindesine or vinorelbine. Detailed results, as well as subgroup analyses, will be presented at the meeting. [Table: see text]

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39

Horak, Marianne. "The phycitine genera Faveria Walker, Morosaphycita, gen. nov., Epicrocis Zeller, Ptyobathra Turner and Vinicia Ragonot in Australia (Pyralidae: Phycitinae)." Invertebrate Systematics 11, no. 3 (1997): 333. http://dx.doi.org/10.1071/it96002.

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The phycitine genera Faveria Walker, Morosaphycita, gen. nov., Epicrocis Zeller, Ptyobathra Turner and Vinicia Ragonot are revised, based on their type species and 18 Australian species. Comprehensive descriptions and illustrations are given for the Australian species and the genitalia of some critical species from outside Australia are figured. Oligochroa Ragonot, Pristarthria Ragonot and Sclerobia Ragonot are junior synonyms of Faveria, with six Australian species including the type species Faveria laiasalis Walker and Faveria griseopuncta, sp. nov. Morosaphycita, gen. nov., is proposed for a group of species including the complex of Morosaphycita morosalis (SaalmÜller) with two new Australian species, the type of the genus M. tridens, sp. nov., and M. bispinosa, sp. nov. Canthelea Walker is treated as a junior synonym of Epicrocis, and E. festivella Zeller and E. oegnusalis (Walker) are part of two species complexes each including Australian species, E. pulchra, sp. nov., and E. atrilinea, sp. nov., with the former and E. metallopa (Lower) with the latter. Ptyobathra is based on an Australian species, but extends to Sri Lanka and Japan, whereas Vinicia is so far known only from Australia and New Zealand. Vinicia gypsopa (Meyrick) is synonymised with Vinicia digrammella (Meyrick). Lectotypes are designated for Pempelia strigiferella Meyrick, Pempelia rufitinctella Meyrick, Pempelia caliginosella Meyrick, Eucarphia cnephaeella Meyrick, Nephopteryx dasyptera Lower, Pempelia oculiferella Meyrick, Homoeosoma gratella Walker, Oligochroa atrisquamella Hampson, Nephopteryx hades Lower, Pempelia digrammella Meyrick, Salebria gypsopa Meyrick and Epicrocis macrota Meyrick.

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40

Jean-Decoster, Catherine, Laetitia Brichese, Jean-Marc Barret, Yvette Tollon, Anna Kruczynski, Bridget T. Hill, and Michel Wright. "Vinflunine, a new vinca alkaloid." Anti-Cancer Drugs 10, no. 6 (July 1999): 537–44. http://dx.doi.org/10.1097/00001813-199907000-00005.

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Toso, Cindy, and Celeste Lindley. "Vinorelbine: A novel vinca alkaloid." American Journal of Health-System Pharmacy 52, no. 12 (June 1995): 1287–304. http://dx.doi.org/10.1093/ajhp/52.12.1287.

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42

Keever, Gary J., Josh B. Clark, and Teresa A. Morrison. "Growth Regulation of Vinca minor." Journal of Environmental Horticulture 23, no. 1 (March 1, 2005): 14–16. http://dx.doi.org/10.24266/0738-2898-23.1.14.

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Abstract Multiple applications of three rates each of B-Nine/Cycocel, Sumagic, Cutless, and Atrimmec were applied to common periwinkle grown in small containers in a greenhouse to control runner growth. All plant growth regulators (PGRs) suppressed runner elongation throughout the 30-week study. However, Atrimmec at 1500 to 4500 ppm severely injured plants for up to 20 weeks, and Cutless at 30 to 90 ppm reduced the number of runners for at least 24 weeks. There were no adverse effects associated with the application of B-Nine/Cycocel or Sumagic at the rates tested, 2500/1500 to 7500/1500 ppm and 15 to 45 ppm, respectively.

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Rahmani, R., R. Samak, P. Bore, and JP Cano. "Clincal pharmacokinetics of vinca alkaloids." Journal of Ethnopharmacology 23, no. 2-3 (July 1988): 344. http://dx.doi.org/10.1016/0378-8741(88)90043-8.

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Keglevich, András, Péter Keglevich, and László Hazai. "Daganatellenes hatású Vinca alkaloidszármazékok szintézise." Magyar Kémiai Folyóirat 127, no. 1 (2021): 31–36. http://dx.doi.org/10.24100/mkf.2021.01.31.

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45

Fisher, John R. "First Report of Arabis mosaic virus Infecting Vinca minor in Ohio." Plant Health Progress 14, no. 1 (January 2013): 43. http://dx.doi.org/10.1094/php-2013-0901-02-br.

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These results represent the first confirmed report of Arabis mosaic virus (ArMV) infecting periwinkle (Vinca minor) in Ohio. Growers should be aware of ArMV as a threat to the industry due to its wide host range and ease of transmission, and of Vinca minor as a potential perennial reservoir for the virus since periwinkle is propagated by seed, division, and by cuttings. Accepted for publication 21 June 2013. Published 1 September 2013.

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46

Kumari, Puja, Vineeta Dixit, Atul Kumar Tiwari, Saurabh Saxena, Naveen Kumar Vishvakarma, Pradeep Kumar Naik, and Dhananjay Shukla. "COMPUTER-ASSISTED DRUG DESIGNING OF TRIAZOLE DERIVATIVE OF NOSCAPINE AS TUBULIN-BINDING ANTICANCER DRUG." Asian Journal of Pharmaceutical and Clinical Research 11, no. 14 (July 27, 2018): 69. http://dx.doi.org/10.22159/ajpcr.2018.v11s2.28586.

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Objective: Microtubule-interfering drugs are commonly used to treat malignant disorders owing to indispensable role of this cytoskeletal element. These drugs include paclitaxel, docetaxel, and the Vinca alkaloids; however, owing to their non-selective action and overpolymerizing effects, these chemotherapy drugs are confounded by complications with serious toxicity (particularly, peripheral neuropathies, gastrointestinal toxicity, myelosuppression, and immunosuppression) (by taxanes) or depolymerizing effects (by Vincas) on microtubules. Thus, there is urgent need to explore novel tubulin-binding agents that are significantly effective and comparatively less toxic compared to currently available drugs for the treatment of human cancer. The current study focuses fusion of two novel anticancer compounds with low toxicity, i.e., noscapine and triazole to generate a new ligand derivative.Methods: Using computer-aided drug designing approach and molecular docking, molecular interaction of these derivatives with αβ-tubulin heterodimer was confirmed and investigated by molecular docking along with dynamics simulation.Results: A greater affinity of the newly designed ligands for binding to tubulin was predicted. The predictive binding free energy (Gbind,pred) of these derivatives (ranging from −10.5178 to −16.8473 kcal/mol) based on linear interaction energy method with a surface generalized born continuum salvation model showed improved binding affinity with tubulin as compared to the lead compound. natural α-Noscapine (−5.505 kcal/mol). The binding energy of ligand determined using LigX, i.e., MM/GBVI was found to be −23.208 kcal/mol.Conclusion: We found that designed derivative compounds have better efficacy as compared noscapine and triazole.

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47

Stefanovic, Nebojsa, Natasa Danilovic-Hristic, and Bosko Josimovic. "The spatial and urban planning concerns related to nuclear facilities locations: Case study of the Vinca Institute location." Nuclear Technology and Radiation Protection 32, no. 1 (2017): 99–108. http://dx.doi.org/10.2298/ntrp1701099s.

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The spatial and urban planning is one of the key instruments for the planned formation and development of locations for nuclear facilities, especially in terms of meeting the strict spatial conditionality, as well as in terms of the formation of protection zones in their surroundings. This paper systemizes the international criteria and requirements for the locations of nuclear facilities and analyses the spatial distribution of nuclear facilities in the surrounding countries of the Republic of Serbia. The research was conducted on the example of the location of the Vinca Institute of Nuclear Sciences, within which the fulfilment of spatial requirements, treatment of the location in the existing spatial and urban plans and relationship between other functions in the surrounding area were analysed. The paper proves the starting hypothesis that the general requirements related to both the spatial development of nuclear facilities locations and the protection from radiation have not been met in the Vinca location and its surroundings. It was determined that the spatial and urban plans encompassing the area of Vinca do not contain sufficiently specific planning solutions and that, as such, they do not provide a sufficient planning basis for meeting the necessary requirements and obligations regarding the protection from radiation. The paper also gives recommendations for further spatial development and protection of the Vinca location and its surroundings. The research condcted in this paper indicates the importance and priority of further research so that the necessary planning solutions for further development of the complex in Vinca and for the formation of protection zones could be defined through creating a new planning documentation. In addition, the paper particularly highlights the need for conducting a research to identify a location for permanent disposal of radioactive waste. It also indicates the necessity of considering the aspects of environmental protection and protection from radiation in the national and international context.

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V. V. M,, Anand Priya, K. Kranthi, K. Punnagai, and Darling Chellathai David. "Evaluation of Alpha-Glucosidase Inhibitory Activity of Vinca Rosea." Biomedical and Pharmacology Journal 12, no. 2 (June 28, 2019): 783–86. http://dx.doi.org/10.13005/bpj/1700.

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Diabetes mellitus (DM) has developed into serious health problem worldwide. α-glucosidase inhibitors are used in management of Type II Diabetes mellitus. Medicinal plants are known to be effective in treating various diseases and disorders. Catharanthus roseus belonging to family Apocyanaceae is very well known for its anticancer property. The present study was aimed to compare the alpha glucosidase inhibitory effect of leaves and flowers extracts of Vinca rosea by an in-vitro assay. Methanolic extracts were obtained using Soxhlet apparatus. Yeast alpha glucosidase was used as the enzyme source. Acarbose was used as the reference drug. The % inhibition was calculated. The results proved that both leaves and flowers extract of Vinca rosea possess α-glucosidase inhibitor activity. The leaf extract (57.87%) showed a better activity when compared to flower extracts (48.31%). The result supports Vinca rosea as a potential source in treating Diabetes mellitus.

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Montag, Gracia, Helga Stopper, Quoc Anh Ngo, and Henning Hintzsche. "The Biological Activity of the Novel Vinca Alkaloids 4-chlorochablastine and 4-chlorochacristine." Current Cancer Drug Targets 19, no. 3 (February 14, 2019): 222–30. http://dx.doi.org/10.2174/1568009618666180430142233.

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Background: Vinca alkaloids are important cancer drugs belonging to the class of antimitotic agents. The most commonly used substances are vinblastine and vincristine, other compounds are vinorelbine and vinflunine. All of them are very effective drugs but their use is limited by severe side-effects including neurotoxicity and bone marrow depression. Therefore, it is very important to develop novel vinca alkaloids with similar efficacy but lower toxicity. </P><P> Methods: Here, we analyzed two new compounds, 4-chlorochablastine and 4-chlorochacristine, with regard to their biological activity. These novel compounds were applied to a leukemia cell line at clinically relevant concentrations. For comparison, the established vinca alkaloids vinblastine, vincristine, vinorelbine, and vinflunine were also tested. </P><P> Results: Both novel substances decreased cellular proliferation. Apoptosis was found to be increased using two different methods reflecting early and late apoptosis. Cell cycle analysis revealed a clear decrease in G1-cells and an increase in G2/M-cells indicating an arrest in mitosis. In general, 4- chlorochablastine and 4-chlorochacristine caused these effects at concentrations higher than those needed for vinblastine, vincristine, and vinorelbine, but the potency was approximately in the range of vinflunine. </P><P> Conclusion: Taken together, the results show first indications that these novel vinca alkaloids might be effective and that they warrant further analysis.

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Moldvai, István, András Vedres, Gábor Tóth, Csaba Szántay, and Csaba Szántay. "Synthesis of vinca alkaloids and related compounds XXXI unusual polonovski reaction of some vinca alkaloids." Tetrahedron Letters 27, no. 24 (1986): 2775–78. http://dx.doi.org/10.1016/s0040-4039(00)84641-9.

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