Journal articles: 'Verità biologica'

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Belozorovich, Anna. "Volpi, farfalle, uccelli e un cagnolino nero: il mimetismo e la sopravvivenza sotto il regime staliniano in Vesti bianche di Vladimir Dudincev." Altre Modernità, no. 26 (November 29, 2021): 145–64. http://dx.doi.org/10.54103/2035-7680/16802.

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L’articolo prende in esame Vesti bianche (Belye odeždy), il secondo romanzo di Vladimir Dudincev (1918-1998), figura tragica della letteratura sovietica. Dopo Non si vive di solo pane (1957), riscuote un enorme successo ma viene costretto al silenzio a causa dello scandalo politico che ne deriva. Vesti bianche, scritto nel 1966, ma pubblicato solo vent’anni più tardi (1987), è ambientato nel pieno del lysenkoismo, la violenta repressione nei confronti della comunità scientifica che ebbe luogo tra gli anni ’40 e ’50. I suoi protagonisti sono biologi: comprendere la natura, essere in dialogo con il mondo naturale, è la loro prerogativa per ottenere dei risultati. La riflessione scientifica è puntualmente accompagnata da quella filosofica. In una intensa discussione sul rapporto tra l’uomo e la Natura, i protagonisti si schierano su differenti posizioni e sembrano “indossare” figure animali quasi con valore totemico. Le possibili configurazioni della società umana, i rapporti professionali e le esperienze individuali vengono messe in relazione con il comportamento animale. Il carattere associato a questi animali riporta sia al loro comportamento in natura sia alla simbologia ad essi legata nella tradizione popolare russa. La ricerca della verità da parte degli uomini di scienza incontra la necessità di mascheramento, parola chiave della trama. Il mimetismo è vissuto come un inganno necessario, come per mantenere la varietà biologica nel mondo naturale, così per garantire la libertà del pensiero e della ricerca scientifica in un paese paralizzato dal regime.

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Feng, Yue, Baosen Zhou, Zhen Wang, Guijuan Xu, Lili Wang, Tingting Zhang, and Yanping Zhang. "Risk of Candida Infection and Serious Infections in Patients with Moderate-to-Severe Psoriasis Receiving Biologics: A Systematic Review and Meta-Analysis of Randomized Controlled Trials." International Journal of Clinical Practice 2022 (September 21, 2022): 1–11. http://dx.doi.org/10.1155/2022/2442603.

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Background. Biological agents used to treat moderate-to-severe plaque psoriasis have been associated with Candida infection and other serious infections. It is, however, necessary to verify whether biologic agents increase the risk of Candida infection and serious infections and whether these risks vary among biologics. Methods. PubMed, EMBASE, and Cochrane Library were searched for eligible randomized controlled trials (RCTs) from their inception to December 2021. Results from individual RCT were pooled using Peto’s method with a fixed-effects model, and I2 was calculated to assess the heterogeneity. A Cochrane collaboration tool was used to examine bias risk, and Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) were used to assess the quality of evidence. Results. This study included 48 published articles with data from 52 RCTs involving 27297 participants. The anti-interleukin (IL)-17 agents (95% confidence interval (CI) = 1.54–3.45, P < 0.0001 ) and anti-IL-12/23 agents (95% CI = 1.69–3.83, P < 0.0001 ) were associated with an increased risk of Candida infection compared with placebos, but there was no difference in Candida infection risk between anti-IL-17 agents and tumor necrosis factor inhibitors (TNFi) (95% CI = 0.92–3.07, P = 0.09 ). There was no evidence that the biological agents increased the risk of serious infections in adult psoriasis (95% CI = 0.93–2.06, P = 0.11 ) or that the biologics differed in the risk of serious infections. Conclusions. Our results indicated that anti-IL-17 agents, especially secukinumab, were associated with the increased risk of Candida infection. The clinically used biological agents did not increase the risk of serious infections.

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Kroese, Dinant, Chanel Lau, and Andre Wolterbeek. "Exploring the ZET as biological model to verify grouping of chemicals for DART." Reproductive Toxicology 56 (August 2015): 23. http://dx.doi.org/10.1016/j.reprotox.2015.07.051.

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Barragán, Jorge. "Hologram: Beyond Biological Aging." Gerontology and Geriatric Medicine 8, no. 5 (December 31, 2022): 1–4. http://dx.doi.org/10.24966/ggm-8662/100149.

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Spies, Maria. "DNA Repair: Trust but Verify." Current Biology 23, no. 3 (February 2013): R115—R117. http://dx.doi.org/10.1016/j.cub.2012.12.019.

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Carvalho, Lídia Raquel de, Sheila Zambello de Pinho, and Martha Maria Mischan. "Methods to verify parameter equality in nonlinear regression models." Scientia Agricola 67, no. 2 (April 2010): 218–22. http://dx.doi.org/10.1590/s0103-90162010000200014.

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In biologic experiments, in which growth curves are adjusted to sample data, treatments applied to the experimental material can affect the parameter estimates. In these cases the interest is to compare the growth functions, in order to distinguish treatments. Three methods that verify the equality of parameters in nonlinear regression models were compared: (i) developed by Carvalho in 1996, performing ANOVA on estimates of parameters of individual fits; (ii) suggested by Regazzi in 2003, using the likelihood ratio method; and (iii) constructing a pooled variance from individual variances. The parametric tests, F and Tukey, were employed when the parameter estimators were near to present the properties of linear model estimators, that is, unbiasedness, normal distribution and minimum variance. The first and second methods presented similar results, but the third method is simpler in calculations and uses all information contained in the original data.

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Migone, Paolo. "Una critica all'articolo di Manfred Pohlen "Il potere d'influenzamento dell'analista e la veritŕ del suo metodo"." PSICOTERAPIA E SCIENZE UMANE, no. 4 (December 2010): 515–25. http://dx.doi.org/10.3280/pu2010-004005.

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Viene criticato l'articolo di Manfred Pohlen (2005) "Il potere d'influenzamento dell'analista e la veritŕ del suo metodo", pubblicato nel numero scorso di Psicoterapia e Scienze Umane (2010, XLIV, 3: 345-364). Alcune critiche sono le seguenti: il potere suggestivo della psicoanalisi, dimostrato anche empiricamente, era giŕ discusso da Freud e da autori successivi (si pensi ai fattori relazionali e identificatori, o al "transfert positivo irreprensibile"); una dicotomizzazione netta tra scienze naturali e scienze umane puň considerarsi datata; l'influenza del terapeuta nel guidare il paziente in senso prospettico era presente in Jung ed č stata ripresa dall'ermeneutica; la psicoanalisi come capace di attivare potenzialitŕ inespresse si sovrappone al concetto di autorealizzazione (self-actualizazion) di Rogers e in generale della psicoterapia umanistica; nella teoria dell'attaccamento di Bowlby non vi č un riduzionismo biologico ma un'enfasi sulle relazioni oggettuali; e cosě via.

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Cai, Yizhi, Brian Hartnett, Claes Gustafsson, and Jean Peccoud. "A syntactic model to design and verify synthetic genetic constructs derived from standard biological parts." Bioinformatics 23, no. 20 (September 5, 2007): 2760–67. http://dx.doi.org/10.1093/bioinformatics/btm446.

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BAŞTUĞ, Gizem, Yasin Burak HAL, Gökhan BAKTEMUR, Mahmut YARAR, Ecem KARA, and Hatıra TAŞKIN. "Effect of growing mixtures including different agricultural wastes on yield and quality of Pleurotus eryngii." Mustafa Kemal Üniversitesi Tarım Bilimleri Dergisi 27, no. 3 (December 1, 2022): 578–87. http://dx.doi.org/10.37908/mkutbd.1098660.

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Aims: In this study, it was aimed to determine the effects of different agricultural wastes on yield and quality of the Pleurotus eryngii culture, which has very limited production in Turkey.Methods and Results: Spawn of P. eryngii were inoculated to substrate mixtures; oak sawdust (K), 2 oak sawdust + 1 wheat bran (G1), 2 poplar sawdust + 1 wheat bran (G2), 2 wheat stalk + 1 wheat bran (G3), 1 oak sawdust + 1 poplar sawdust + 1 wheat bran (G4), 1 oak sawdust + 1 wheat stalk + 1 wheat bran (G5), 2 peanut shell + 1 wheat bran (G6), 2 corn cob + 1 wheat bran (G7), 2 vine pruning waste +1 wheat bran (G8), 1 peanut shell + 1 oak sawdust + 1 wheat bran (G9), 1 corn cob + 1 oak sawdust + 1 wheat bran (G10), 1 vine pruning waste +1 oak sawdust + 1 wheat bran (G11). As a result of the study, while the shortest mycelia development time was recorded in G6 and G9 with 17 days, the longest time was in G4 medium with 30 days. The highest and the lowest yield were obtained from G6 and G3 with 171.14 g kg-1 bag and 53.26 g kg-1 respectively. While the highest biological efficiency was found in G9 with 44.86%,the lowest value was recorded in G3 with 17.34%. Conclusions: In yield, biological efficiency and mycelia development time, G6 and G9 mediums were found to be better than the others. When considering the importance of yield, biological efficiency and mycelia development time for producers, the success of peanut shell in P. eryngii culture is noteworthy.Significance and Impact of the Study: When common peanut culture in the Çukurova Region of Türkiye is considered, it is an important result that the waste of this plant can be used in the mushroom cultivation.

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Keats, Jonathan J., Marta Chesi, W. Michael Kuehl, and P. Leif Bergsagel. "A Simple and Reliable Method To Verify the Authenticity and Purity of Human Myeloma Cell Lines." Blood 110, no. 11 (November 16, 2007): 2485. http://dx.doi.org/10.1182/blood.v110.11.2485.2485.

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Abstract The availability of human myeloma cell lines (HMCLs) has drastically benefited out understanding of multiple myeloma (MM). They represent essential resources to the myeloma research community at large who use them to identify and more importantly validate oncogenic events in MM. Furthermore, they represent the front line tools in efforts to identify novel therapeutic agents for MM patients. However, the myeloma research community is not immune to problems of cell line contamination (mixed populations) or systemic errors where HMCLs are labeled incorrectly. As the community evolves towards the development of tailor medicine it is essential that our basic tools are both pure and correct. Otherwise, a potentially beneficial therapeutic agent designed for a specific patient subset maybe lost simply because of a simple laboratory mix-up at some point over the years. To that end we have developed a simple PCR based method that can be used to validate the purity and authenticity of HMCLs. First two reference collections of over 50 HMCL maintained at the NCI and Mayo Clinic Arizona were compared using microsatellite fingerprinting. This process identified several previously unnoticed discrepancies. First, in both labs several cell lines that reportedly originated from different patients had the same fingerprints. These include the following unexpected pairs; ANBL-6 and DP–6, CAG and ARP–1, KMS–11 and KMS–20, KMS–11 and KMS–21PE/BM, JIM3 and KPMM2. Second, both KP–6 and KAS6/1 showed a level of cross-contamination with ANBL–6. All of the discrepant cell lines were requested from the original contributor and those that were available were retested. After this step we had identified unique fingerprints for ANBL–6, DP–6, KMS–11, and KMS–20. Furthermore, pure populations of KP–6 and KAS6/1 were confirmed. However, CAG and ARP–1 still had an identical fingerprint. Since the use of microsatellite fingerprinting is an expensive task and the identification of cross-contamination is not very robust we set out to develop better method. We decided to use a simple qualitative PCR method, as the binomial presence or absence of a band makes the interpretation of the fingerprint extremely easy. Furthermore, the high sensitivity of a qualitative PCR can pick up a small amount of contamination in the culture that can be lost in microsatellite analysis. This method involves a multiplex PCR screen that simultaneously interrogates 10 regions of the human genome. The screen is divided into two reactions, one with a panel of highly polymorphic copy number variations (CNV) that are often completely absent in some individuals, and a second one based on known biologic events present in the cell lines. The integration of the results from the CNV and Biological Fingerprints will identify each HMCL as a unique entity. We validated the methodology by confirming that this qualitative screen could pick up the cross–contamination identified in the original KP–6 and KAS6/1 samples. As our understanding of myeloma increases and we strive to develop new therapies for specific biological entities it will be essential that groups confirm both the authenticity and purity of their test cultures. We hope that widespread use of this simple screening methodology will significantly improve the quality and reproducibility of assays carried out in labs around the world.

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Petr, Šařec, Látal Oldřich, and Novák Petr. "Technological and economic evaluation of manure production using an activator of biological transformation." Research in Agricultural Engineering 63, Special Issue (December 22, 2017): S59—S65. http://dx.doi.org/10.17221/50/2017-rae.

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The aim of this paper was to verify the effect of the Z'fix (PRP Technologies, France) activator of biological transformation of manure from the viewpoint of the cowshed conditions parameters, produced manure quality, manure application effect on crop yields, and overall economics. Concerning manure production, the application of the Z'fix agent enhanced quality, structure and nutrient content (N total by 23%, P2O5 by 42%, K2O by 17%) in the manure from deep litter housing. Compared to the untreated control, differences in the nutrient content of N total and K2O were statistically significant, NH3 emissions dropped significantly by almost 35%. The economic benefit of manure production with the use of the Z'fix agent demonstrated overall savings at the level of 1,369 CZK/LU/year. The influence of manure produced combined with the PRP Sol application was tested in terms of a boost of crop yield potential of silage maize and of winter wheat. Compared to the control, both crops reached yields higher by 0.7% to 9.8%.

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Khan, A. Q., and M. N. Qureshi. "Stability analysis of a discrete biological model." International Journal of Biomathematics 09, no. 02 (January 14, 2016): 1650021. http://dx.doi.org/10.1142/s1793524516500212.

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In this paper, we investigate the equilibrium point, local and global behavior of the unique positive equilibrium point, and rate of convergence of positive solutions of following discrete biological model: [Formula: see text] where parameters [Formula: see text] and the initial conditions [Formula: see text] are positive real numbers. Some numerical examples are given to verify theoretical results.

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Fedotov, V. P., N. V. Sadovnikova, V. I. Gudoshnikov, I. N. Baranova, L. L. Vasilyeva, and К. K. Pivnitsky. "Biological properties of hepoxylines." Problems of Endocrinology 43, no. 3 (September 18, 2019): 8–12. http://dx.doi.org/10.14341/probl10386.

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Hepoxylines, arachidonic acid metabolites, are present in many tissues of the body and regulate various cell functions. We investigated the biological effects of hepoxylines B3 (10R and 10S epimers) on the secretory processes using primary cultures of rat pancreatic islet cells, adenohypophyseal ceils, and hepatocytes. Hepoxylines added to culture medium boosted the secretion of insulin and serum albumin and inhibited prolactin secretion. Hepoxyline effect on insulin secretion did not depend on the presence of glucose in the medium. Experiments on a model of type 11 diabetes showed that exogenous hepoxylines partially repair the islet cell sensitivity to glucose. Impaired synthesis of hepoxylines and their metabolism or receptor interactions with pancreatic p-cells may be one pathogenetic factor in the development of non-insulindependent diabetes mellitus. In order to verify this hypothesis, methods and agents boosting and inhibiting the production of endogenous hepoxylines are needed and the effects of hepoxylines on tissues resistant to insulin because of type II diabetes are to be studied.

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Nakamae, Ikuko, Tsumoru Morimoto, Hiroki Shima, Masafumi Shionyu, Hisayo Fujiki, Noriko Yoneda-Kato, Takashi Yokoyama, et al. "Curcumin Derivatives Verify the Essentiality of ROS Upregulation in Tumor Suppression." Molecules 24, no. 22 (November 10, 2019): 4067. http://dx.doi.org/10.3390/molecules24224067.

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Background: Curcumin has been shown to exert pleiotropic biological effects, including anti-tumorigenic activity. We previously showed that curcumin controls reactive oxygen species (ROS) levels through the ROS metabolic enzymes, to prevent tumor cell growth. In this study, we synthesized 39 novel curcumin derivatives and examined their anti-proliferative and anti-tumorigenic properties. Methods and Results: Thirty-nine derivatives exhibited anti-proliferative activity toward human cancer cell lines, including CML-derived K562 leukemic cells, in a manner sensitive to an antioxidant, N-acetyl-cysteine (NAC). Some compounds exhibited lower GI50 values than curcumin, some efficiently induced cell senescence, and others markedly increased ROS levels, efficiently induced cell death and suppressed tumor formation in a xenograft mouse model, without any detectable side effects. A clustering analysis of the selected compounds and their measurement variables revealed that anti-tumorigenic activity was most well-correlated with an increase in ROS levels. Pulldown assays and a molecular docking analysis showed that curcumin derivatives competed with co-enzymes to bind to the respective ROS metabolic enzymes and inhibited their enzymatic activities. Conclusions: The analysis of novel curcumin derivatives established the importance of ROS upregulation in suppression of tumorigenesis, and these compounds are potentially useful for the development of an anti-cancer drug with few side effects.

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ÖZER, Harun, and Dilek KANDEMİR. "Domates Yetiştiriciliğinde Koltuk Sürgünleri ile Üretilen Fidelerin Büyüme, Gelişme ve Verime Etkisi." Yüzüncü Yıl Üniversitesi Tarım Bilimleri Dergisi 27, no. 2 (June 30, 2017): 165–71. http://dx.doi.org/10.29133/yyutbd.265399.

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Moravia, Wagner Guadagnin, Victor Rezende Moreira, Yuri Abner Rocha Lebron, Liséte Celina Lange, and Míriam Cristina Santos Amaral. "Influence of humic substances on the landfill leachate biodegradability with a focus on temporal seasonality." Water Science and Technology 84, no. 12 (November 18, 2021): 3780–90. http://dx.doi.org/10.2166/wst.2021.499.

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Abstract The high resilience to biological treatments from the landfill leachate is generally associated with the presence of humic substances (HS). The brown color characteristic of this effluent is also related to these substances. Landfill leachate with low biodegradability can make biological treatments unfeasible, which can drive up the cost for the treatment of large leachate volumes. In this context, this research aimed to characterize the leachate in different seasonal periods, and verify the influence of HS species on the biodegradability of the effluent to assist in the selection of adequate treatment techniques. The HS quantification was performed using the modified Lowry method and speciation through fractionation according to the molar masses of the HS species. The tropical regions can be the precursor for the rapid stabilization of biodegradable organic matter. The warmer climate contributed to a reduced BOD/COD ratio (0.03) and the predominance of compounds of lower mass (e.g.: fulvic acids). The tests showed an HS concentration of 26.9% of the total COD in the raw leachate in the rainy season, which increased to 37.3% in the dry season. Approximately 70% of HS species refer to fulvic acids, a fraction identified as having the highest biologic treatment resilience.

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Chevrier, Marie Isabelle. "Verifying the Unverifiable: Lessons from the Biological Weapons Convention." Politics and the Life Sciences 9, no. 1 (August 1990): 93–105. http://dx.doi.org/10.1017/s073093840001025x.

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The Biological Weapons Convention (BWC) is widely regarded as a treaty whose provisions are difficult to verify because of the paucity of measures to verify compliance within the treaty framework and the nature of the weapons themselves. Advances in biotechnology and their effect on the perceived military utility of biological weapons have focused international attention on this issue. This article examines the concepts of “adequate” and “effective” verification and argues that the treaty falls under the definition of adequate verification in the United States. For other countries, however, the lack of verification measures is of greater concern. The article describes measures that should be added to the BWC to detect violations and promote compliance with the treaty. These include improved methods of resolving allegations of noncompliance, increased reporting requirements for activities permitted under the treaty, greater openness in biological research, and inspections of laboratories and other facilities.

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Pârvu, Ovidiu, and David Gilbert. "A Novel Method to Verify Multilevel Computational Models of Biological Systems Using Multiscale Spatio-Temporal Meta Model Checking." PLOS ONE 11, no. 5 (May 17, 2016): e0154847. http://dx.doi.org/10.1371/journal.pone.0154847.

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Laurenti, R., F. Giovannangeli, E. Gubinelli, M. T. Viviano, A. Errico, L. Leoni, E. Ballanti, and A. Migliore. "Long-Term Safety of Anti-TNF Adalimumab in HBc Antibody-Positive Psoriatic Arthritis Patients: A Retrospective Case Series of 8 Patients." Clinical and Developmental Immunology 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/410521.

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Immunosuppressive drugs commonly used in the treatment of psoriatic arthritis make patients more susceptible to viral, bacterial, and fungal infections because of their mechanism of action. They not only increase the risk of new infections but also act altering the natural course of preexisting infections. While numerous data regarding the reactivation of tuberculosis infection are available in the literature, poor information about the risk of reactivation or exacerbation of hepatitis viruses B and C infections during treatment with biologics has been reported. Furthermore, reported series with biological therapy included short periods of followup, and therefore, they are not adequate to verify the risk of reactivation in the long-term treatment. Our study evaluated patients with a history of hepatitis B and psoriatic arthritis treated with adalimumab and monitored up to six years. During the observation period, treatment was effective and well tolerated in all patients, and liver function tests and viral load levels remained unchanged.

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Pandey, Ritesh, R. N. Singh, and P. N. Pandey. "Mathematical Model for Malaria Transmission and Biological Control." Journal of the Tensor Society 8, no. 01 (June 30, 2009): 159–73. http://dx.doi.org/10.56424/jts.v8i01.10549.

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In this paper, a nonlinear mathematical model for the control of vector borne diseases, like malaria is proposed and analyzed. In the modeling process it is assumed that the mosquito population is controlled by using larvivorous fish, which partially depends on the larva of mosquito population. It is further assumed that the mosquito population grows logistically. The equilibria of the model are obtained and their stability is discussed by using stability theory of differential equations. Further numerical simulation is performed to verify the analytically obtained results.

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Moreno, Carolina dos Santos, Sizue Ota Rogero, Tamiko Ichikawa Ikeda, Áurea Silveira Cruz, and José Roberto Rogero. "Resveratrol and radiation biological effects." International Journal of Nutrology 05, no. 01 (January 2012): 028–33. http://dx.doi.org/10.1055/s-0040-1701425.

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ABSTRACTResveratrol is a phytoalexin, a phenolic compound present in wines and several plants. This compound is related to a broad spectrum of biological activities such as antioxidant and anticarcinogenic effects that are very important in prevention of cancer, cardiovascular diseases and other diseases caused by oxidative processes. Over the last years, biological effects of ionizing radiation in the presence of resveratrol have been studied in different cell cultures. The aim of this study was to verify the effect of gamma radiation on mouse connective tissue cells (NCTC clone 929) in culture in the presence of trans-resveratrol. Cell viabilities were analyzed by neutral red uptake assay. The results demonstrated in vitro the radioprotective effect of trans-resveratrol on cell culture and it was more pronounced when cell culture was irradiated at 500-800 Gy doses in the presence of resveratrol concentrations between 12.5 and 25 μM. These results provide evidence that trans-resveratrol alters the cellular response to ionizing radiation, expanding the knowledge of resveratrol biological properties in physiological and pathological processes, contributing to the development of future studies about the possibility of including resveratrol and its derivatives in dietary supplements given to cancer patients during radiotherapy.

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Phebus, Randall C., Nicholas J. Sevart, Nicholas W. Baumann, and Randall K. Phebus. "Electrostatic spray cabinet evaluation to verify uniform delivery of chemical and biological solutions to pre-chilled meat animal carcasses." Kansas Agricultural Experiment Station Research Reports, no. 1 (January 1, 2014): 115–18. http://dx.doi.org/10.4148/2378-5977.1472.

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Liu, Bing, Ian Jarvis, Daisuke Naka, Rajeev Goel, and Hidenari Yasui. "A benchmark simulation to verify an inhibition model on decay stage for nitrification." Water Science and Technology 68, no. 6 (September 1, 2013): 1242–50. http://dx.doi.org/10.2166/wst.2013.327.

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Activated Sludge Models (ASMs) are widely used for biological wastewater treatment plant design, optimisation and operation. In commonly used ASMs, the nitrification process is modelled as a one-step process. However, in some process configurations, it is desirable to model the concentration of nitrite nitrogen through a two-step nitrification process. In this study, the benchmark datasets published by the Water Environment Research Foundation (WERF) were used to develop a two-step nitrification model considering the kinetics of Ammonium Oxidising Bacteria (AOB) and Nitrite Oxidising Bacteria (NOB). The WERF datasets were collected from a chemostat reactor fed about 1,000 mg-NH3-N/L synthetic influent with at different sludge retention times of 20, 10 and 5-d, whereas the pH in the reactor varied in the range of 5.8 and 8.8. Supplemental laboratory batch experiments were conducted to assess the toxicity of nitrite-N on nitrifying bacteria. These tests suggested that 500 mg-N/L of nitrite at pH 7.3 was toxic to NOB and resulted in continuous decrease in bulk oxygen uptake rate. To model this phenomenon, a poisoning model was used instead of the traditional Haldane-type inhibition model. The poisoning model for NOB and AOB with different threshold poisonings for unionised NO2-N and NH3-N concentrations could successfully reproduce the three WERF datasets.

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Lysenko, T. M. "SynBioSys Europe — an European biological information system." Vegetation of Russia, no. 12 (2008): 131–33. http://dx.doi.org/10.31111/vegrus/2008.12.131.

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Information systems give new perspectives for vegetation science as well as for management and evaluation of biodiversity on species, community and landscape levels. Information system SynBioSys Europe was initiated by the working group «European Vegetation Survey» of the International Association for Vegetation Science. This project is coordinated by Alterra research institute in Wageningen, the Netherlands. SynBioSys Europe is aimed to integrate information on plant species, plant communities and landscapes of Europe. Different environmental institutions, nature conservation agencies and organizations can exchange information and to share an interpretation of research results both in national and European scale. The system will function as a network of databases operated through a web-server. Researchers will have access to common databases; they can verify their data and solve some scientific problems. The application of GIS-technologies will provide visualization of data on plant species, vegetation and landscapes.

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Berens, Sam C., Jessica S. Horst, and Chris M. Bird. "Cross-Situational Learning Is Supported by Propose-but-Verify Hypothesis Testing." Current Biology 28, no. 7 (April 2018): 1132–36. http://dx.doi.org/10.1016/j.cub.2018.02.042.

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Kaštylová, Kristýna, Karin Černá, Štěpánka Luxová, Petr Šebek, and Milan Lukáš. "Point-of-care method for measuring infliximab and adalimumab trough levels in inflammatory bowel disease patients on biologic therapy." Gastroenterologie a hepatologie 76, no. 1 (February 28, 2022): 35–41. http://dx.doi.org/10.48095/ccgh202235.

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Aim of the study: To verify whether the results of infliximab and adalimumab concentration measurements by the point-of-care method ProciseDx correspond with the concentrations determined by enzyme-linked immunosorbent assay (ELISA). Methods: Twenty-three infliximab (IFX) and twenty-two adalimumab (ADL) concentrations were compared. IFX and ADL trough levels were measured by the ProciseDx point-of-care (POCT) system based on the Förster resonance energy transfer (FRET) principle, and by standard immunoassay (ELISA) in a clinical laboratory. Results: Spearman‘s correlation coefficient for IFX R = 0.9400 (P = 0.0001) and the weighted Cohen‘s kappa of 0.93 indicate a good correlation between data measured by two different measurement systems. The same excellent correlation of values was achieved for ADL, where R = 0.9098 (P = 0.0001) and the weighted Cohen‘s kappa is 0.834. Conclusion: The ProciseDx POCT system is a highly reliable method for measuring serum trough IFX and ADL levels in IBD patients. It is easy to operate and fast, it brings more effectiveness to the IBD biological treatment and reduces financial and time burden of this therapy. Keywords inflammatory bowel disease, infliximab, adalimumab, biologic therapy, proaktivní terapeutické monitorování léčiv, reaktivní terapeutické monitorování léčiv, point-of-care monitoring

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De Castro, Olga, Maria Comparone, Antonietta Di Maio, Emanuele Del Guacchio, Bruno Menale, Jacopo Troisi, Francesco Aliberti, Marco Trifuoggi, and Marco Guida. "Correction: What is in your cup of tea? DNA Verity Test to characterize black and green commercial teas." PLOS ONE 13, no. 1 (January 30, 2018): e0192334. http://dx.doi.org/10.1371/journal.pone.0192334.

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Tang, Tongtong, Xing Sun, Qin Liu, Yuanhua Dong, and Yuyong Xiang. "Different effects of soil bacterial communities affected by biocontrol agent YH-07 on tomato Fusarium wilt inhibition." RSC Advances 10, no. 58 (2020): 34977–85. http://dx.doi.org/10.1039/d0ra05452f.

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The model plant tomato was used to verify the effect and mechanism of a novel discovered strain YH-07 which is a potential agent for biological control of soil borne disease named tomato Fusarium wilt.

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Ayala, Guillermo, and Amelia Simó. "Correlations in bivariate point processes: some biological applications." Advances in Applied Probability 28, no. 2 (June 1996): 330. http://dx.doi.org/10.2307/1428038.

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Let (Φ1 Φ2) be a bivariate point process. Let be the probability that (Φ1 Φ2) - (0, s) (the process without the 0 and s points) verify U when we have a point of <1>1 in the origin and a point of Φ2 in s. This is the reduced cross Palm distribution. Some correlation measures for bivariate point processes based on this reduced cross Palm distribution are proposed. Their estimators and expressions under the independence and the random labelling hypothesis are considered. The differences and improvements with respect to the cross intensity function and its integrated version, the cross function (Stoyan et al. 1987), are studied. Some Monte Carlo tests for testing the independence and the random labelling hypothesis are proposed. They are applied to real bivariate point patterns: positions of hickories and maples in the Lansing Woods (Diggle 1983) and cases and controls of childhood leukaemia and lymphoma in North Humberside (Cuzick and Edwards 1990).

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Ayala, Guillermo, and Amelia Simó. "Correlations in bivariate point processes: some biological applications." Advances in Applied Probability 28, no. 02 (June 1996): 330. http://dx.doi.org/10.1017/s0001867800048199.

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Let (Φ1 Φ2) be a bivariate point process. Let be the probability that (Φ1 Φ2) - (0, s) (the process without the 0 and s points) verify U when we have a point of <1>1 in the origin and a point of Φ2 in s. This is the reduced cross Palm distribution. Some correlation measures for bivariate point processes based on this reduced cross Palm distribution are proposed. Their estimators and expressions under the independence and the random labelling hypothesis are considered. The differences and improvements with respect to the cross intensity function and its integrated version, the cross function (Stoyan et al. 1987), are studied. Some Monte Carlo tests for testing the independence and the random labelling hypothesis are proposed. They are applied to real bivariate point patterns: positions of hickories and maples in the Lansing Woods (Diggle 1983) and cases and controls of childhood leukaemia and lymphoma in North Humberside (Cuzick and Edwards 1990).

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Xue, Linyan, Xiaoke Zhang, Fei Xie, Shuang Liu, and Peng Lin. "Frequent Patterns Algorithm of Biological Sequences based on Pattern Prefix-tree." International Journal of Computers Communications & Control 14, no. 4 (August 5, 2019): 574–89. http://dx.doi.org/10.15837/ijccc.2019.4.3607.

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In the application of bioinformatics, the existing algorithms cannot be directly and efficiently implement sequence pattern mining. Two fast and efficient biological sequence pattern mining algorithms for biological single sequence and multiple sequences are proposed in this paper. The concept of the basic pattern is proposed, and on the basis of mining frequent basic patterns, the frequent pattern is excavated by constructing prefix trees for frequent basic patterns. The proposed algorithms implement rapid mining of frequent patterns of biological sequences based on pattern prefix trees. In experiment the family sequence data in the pfam protein database is used to verify the performance of the proposed algorithm. The prediction results confirm that the proposed algorithms can’t only obtain the mining results with effective biological significance, but also improve the running time efficiency of the biological sequence pattern mining.

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Li, Yao, and Hirotaka Sato. "Insect-Computer Hybrid Robot." Molecular Frontiers Journal 02, no. 01 (January 2018): 30–42. http://dx.doi.org/10.1142/s2529732518500025.

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An insect–computer hybrid robot, often referred to as a biological machine or an insect cyborg, is the fusion of a living insect platform and artificial microdevices, including stimulators, sensors, and computers. When compared with the artificial robots, a hybrid robot can be operated as an autonomous mobile machine with low energy consumption and hardware costs. A hybrid machine can verify various biological hypotheses, such as function determination, by stimulating a muscle or any other structure.

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Sekulic, Dalibor, and Miljko Sataric. "Microtubule as nanobioelectronic nonlinear circuit." Serbian Journal of Electrical Engineering 9, no. 1 (2012): 107–19. http://dx.doi.org/10.2298/sjee1201107s.

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In recent years, the use of biological molecules has offered exciting alternatives to conventional synthetic methods. Specific methods use various biological templates to direct the deposition and patterning of inorganic materials. Here we have established a new electrical model of microtubules as a biological nanoscale circuit based on polyelectrolyte features of cylindrical biopolymers. Our working hypothesis is that microtubules play an active role in sub-cellular computation and signaling via electronic and protonic conductivity and can thus be made useful in hybrid materials that offer novel electronic characteristics. We verify these hypotheses both computationally and analytically through a quantitative model based on the atomic resolution structures of the key functional proteins.

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Labruyère, Carine, Jean-Luc Reny, Céline Chapelle, Michèle Piot, Pierre Fontana, Jean-Christophe Gris, Xavier Delavenne, Patrick Mismetti, Silvy Laporte, and Nora Mallouk. "Prevalence of poor biological response to clopidogrel." Thrombosis and Haemostasis 107, no. 03 (2012): 494–506. http://dx.doi.org/10.1160/th11-03-0202.

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SummaryThe existence of poor biological response to clopidogrel has been shown in some patients. Despite the increasing number of studies, this phenomenon remains difficult to quantify. We performed a systematic review to estimate the prevalence of poor biological response to clopidogrel and investigate the factors known to modulate this. An exhaustive search was performed. Altogether 171 publications were identified, providing data for a total of 45,664 subjects. The estimated prevalence of poor biological response to clopidogrel ranged from 15.9% to 49.5% according to the platelet function assay employed. The assays most frequently used were light transmittance aggregometry (LTA), the vasodilator-stimulated phosphoprotein (VASP) assay and the Verify -now® assay. For all these assays, higher cut-off values were associated with a lower prevalence of poor biological response to clopidogrel. However, when choosing a fixed cut-off point for each assay, the prevalence of poor biological response to clopidogrel was highly variable suggesting that other factors could modulate poor biological response to clopidogrel. Finally, none of the studied factors could apparently explain the variability of poor biological response to clopidogrel. This meta-analysis shows that the prevalence of poor biological response depends on the assay employed, the cut-off value and on various unidentified additional factors.

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Choo, Sang-Mok, and Young-Hee Kim. "Convergence of a Belief Propagation Algorithm for Biological Networks." Discrete Dynamics in Nature and Society 2019 (July 24, 2019): 1–16. http://dx.doi.org/10.1155/2019/9362179.

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Constructing network models of biological systems is important for effective understanding and control of the biological systems. For the construction of biological networks, a stochastic approach for link weights has been recently developed by using experimental data and belief propagation on a factor graph. The link weights were variable nodes of the factor graph and determined from their marginal probability mass functions which were approximated by using an iterative scheme. However, there is no convergence analysis of the iterative scheme. In this paper, at first, we present a detailed explanation of the complicated multistep process step by step with a network of small size and artificial experimental data, and then we show a sufficient condition for the convergence of the iterative scheme. Numerical examples are given to illustrate the whole process and to verify our result.

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Lambert, Christophe, Cassandra Braxton, Robert Charlebois, Avisek Deyati, Paul Duncan, Fabio La Neve, Heather Malicki, et al. "Considerations for Optimization of High-Throughput Sequencing Bioinformatics Pipelines for Virus Detection." Viruses 10, no. 10 (September 27, 2018): 528. http://dx.doi.org/10.3390/v10100528.

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High-throughput sequencing (HTS) has demonstrated capabilities for broad virus detection based upon discovery of known and novel viruses in a variety of samples, including clinical, environmental, and biological. An important goal for HTS applications in biologics is to establish parameter settings that can afford adequate sensitivity at an acceptable computational cost (computation time, computer memory, storage, expense or/and efficiency), at critical steps in the bioinformatics pipeline, including initial data quality assessment, trimming/cleaning, and assembly (to reduce data volume and increase likelihood of appropriate sequence identification). Additionally, the quality and reliability of the results depend on the availability of a complete and curated viral database for obtaining accurate results; selection of sequence alignment programs and their configuration, that retains specificity for broad virus detection with reduced false-positive signals; removal of host sequences without loss of endogenous viral sequences of interest; and use of a meaningful reporting format, which can retain critical information of the analysis for presentation of readily interpretable data and actionable results. Furthermore, after alignment, both automated and manual evaluation may be needed to verify the results and help assign a potential risk level to residual, unmapped reads. We hope that the collective considerations discussed in this paper aid toward optimization of data analysis pipelines for virus detection by HTS.

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Lin, Xiangyun, Xinrui Wang, Weihai Zhang, Rui Zhang, and Cheng Tan. "An Approximate Method of System Entropy in Discrete-Time Nonlinear Biological Networks." Processes 10, no. 9 (September 1, 2022): 1736. http://dx.doi.org/10.3390/pr10091736.

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This study discusses the calculation of entropy of discrete-time stochastic biological systems. First, measurement methods of the system entropy of discrete-time linear stochastic networks are introduced. The system entropy is found to be characterized by system matrices of the discrete-time biological systems. Secondly, the system entropy of nonlinear discrete-time stochastic biological systems is discussed and is calculated based on a global linearization method. The approximation of the values of system entropy of nonlinear stochastic systems needs to solve an optimization problem that is constrained by a kind of linear matrix inequality (LMI). Finally, a practical biochemical system is provided to verify the effectiveness of the proposed calculation method.

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Magalhães-Guedes, Karina Teixeira, Roberta Oliveira Viana, Roberto Alves Braga Junior, Disney Ribeiro Dias, Camila Duarte Ferreira, Itaciara Larroza Nunes, and Rosane Freitas Schwan. "Laser biosensor use for the microbial metabolic activity assessment of kefir vinegar." Pesquisa Agropecuária Brasileira 53, no. 11 (November 2018): 1276–80. http://dx.doi.org/10.1590/s0100-204x2018001100010.

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Abstract: The objective of this work was to verify the use of a laser biosensor for the microbial metabolic activity assessment of kefir vinegar. Kefir grains were inoculated in apple must and were analyzed daily using the biospeckle technique. The initial biological activity was of 14.21 pixels per absolute value of differences (AVD). The biological activity of kefir grains decreased in the early days of fermentation and increased on the fourth day to 11.51 pixels per AVD; however, on the last day, the biological activity of kefir grains decreased to 7.12 pixels (alcoholic fermentation) and to 6.77 pixels per AVD (acetic fermentation). This new biospeckle methodology facilitates the microbiological control in fermentation processes.

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Tracz, Dobryan M., Kym S. Antonation, and Cindi R. Corbett. "Verification of a Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry Method for Diagnostic Identification of High-Consequence Bacterial Pathogens: TABLE 1." Journal of Clinical Microbiology 54, no. 3 (December 16, 2015): 764–67. http://dx.doi.org/10.1128/jcm.02709-15.

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We examined the utility of a single matrix-assisted laser desorption ionization–time of flight (MALDI-TOF) mass spectrometry method for the identification of security-sensitive biological agents (risk group 3 bacterial pathogens). The goal was 2-fold: to verify a method for inclusion into our scope of accreditation, and to assess the biological safety of extractions. We developed our sample flow to include a tube-based chemical extraction, followed by filtration, before processing on MALDI-TOF MS instruments in a containment level 2 laboratory.

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Filgueira, Kilder Dantas, Maria Carolina Catai Chalita, Fábio Parra Sellera, and Archivaldo Reche-Júnior. "Cytopathology of cutaneous and subcutaneous neoplasms in feline species: a retrospective study." Acta Veterinaria Brasilica 16, no. 3 (August 16, 2022): 220–26. http://dx.doi.org/10.21708/avb.2022.16.3.10717.

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It is estimated that a quarter of all feline neoplasms affect the integumentary system. Cytological examination is of admirable importance for detection of neoplasms in companion animals, being considered a simple and non-invasive method. To date, there are limited information regarding the prevalence of feline skin cancer as well as the use of cytopathology as a diagnostic tool. In this sense, the study aimed to characterize cutaneous and subcutaneous tumors in 192 cats from the archives of a private clinic in São Paulo-SP, Brazil, specialized in the care of felines. Data regarding the animal (breed definition, sex, and age group) and tumor characteristics (biological behavior, cytomorphological category of neoplasm, and cytological suggestion for neoplasm) were obtained in a five-year period. A 95% confidence interval (CI) was estimated to verify the statistical difference between the animal and tumor characteristics. The chi-square test was carried out to verify the association between the tumor biological behavior and animal variables, as well as other tumor characteristics. Most cats were mixed breed and aged 11 to 15 years. Malignant tumors were predominant. A statistical association was observed between cytomorphological category of neoplasm and biological behavior (p<0.001). Mesenchymal (24.5%) and epithelial tumors (25%) presented the highest frequency among those benign and malignant, respectively. The cytological suggestion for neoplasm was also statistically associated with biological behavior (p<0.001). The highest percentage of occurrence of benign and malignant tumors consisted of lipomas (22.9%) and sarcomas (19.3%), respectively.

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Shvartz, Ya Sh, N. V. Stavitskaya, and D. A. Kudlay. "BCG vaccination as protection from COVID-19: epidemiological and molecular biological aspects." Tuberculosis and Lung Diseases 98, no. 5 (June 3, 2020): 6–14. http://dx.doi.org/10.21292/2075-1230-2020-98-5-6-14.

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The article presents a review of the recent hypothesis that the national policy of BCG-vaccination affects the spread of COVID-19 in different countries. It contains the information from 70 publications with epidemiological indicators, providing pros and cons of this hypothesis, with the description of possible mechanisms of non-specific antiviral action of BCG vaccine. It is concluded that there are not enough data to verify or refute the hypothesis, and at the moment the use of BCG vaccine to prevent the spread of the infection even in high-risk groups would be unreasonable.

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Moodie, Stuart L., Anatoly Sorokin, Igor Goryanin, and Peter Ghazal. "A Graphical Notation to Describe the Logical Interactions of Biological Pathways." Journal of Integrative Bioinformatics 3, no. 2 (December 1, 2006): 177–87. http://dx.doi.org/10.1515/jib-2006-36.

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Summary The modelling of biological intra-cellular pathways requires the systematic capture and representation of interactions between components that are biologically correct and computationally rigorous. The challenge is two fold, to verify and extend our understanding of such pathways by comparing in silico models to experiments; and to ensure that such models are understandable by biologists and for checking biological validity. In this report we present a graphical notation, the Edinburgh Pathway Notation (EPN), which satisfies the central biologically driven requirements while providing a strict formal framework for analysis. The EPN emphasises the use of a logical representation of pathways, which is particularly suited to pathways were some mechanisms are not known in detail.

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Wan, Jun Mei, and Ming Zhang Ao. "Experimental Study of Biological Material Preparation Based on Optical and Mechanical Dynamics." Applied Mechanics and Materials 556-562 (May 2014): 366–70. http://dx.doi.org/10.4028/www.scientific.net/amm.556-562.366.

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The main components of Konjac glucomannan are glucose and glucomannan that are byڂ1-4 bond [ molar ratio is 1.6: (1~4) ] of high molecular weight non-ionic glucomannan, special glucose and mannose's ڂ-1-4chain structure isn't affected by the human digestive enzymes, and does not generate heat. According to the peculiar properties of konjac glucomannan, through the scientific experiment in the body of a rabbit to verify its unique immunological function, and then the human experiments after the effective experimental data statistics scientific analysis, finally the system can obtain the effect of konjac glucomannan on human immune system.

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Watanabe, Nobuyuki, and Kozo Taguchi. "Theoretical Study of Optical Vibration and Circulation of a Microsphere." Key Engineering Materials 516 (June 2012): 563–68. http://dx.doi.org/10.4028/www.scientific.net/kem.516.563.

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In this paper, we proposed an optical vibration and circulation technique of a microsphere using plural optical flat-top fibres, mounted horizontally on the bottom of a sample chamber, and verify that an optically trapped object can be circulated by controlling laser power emerging from optical fibres without moving the optical fibres. We theoretically analyzed the optical forces exerted on a microsphere, a 10μm diameter polystyrene particle (refractive index 1.59), by laser beams. From these theoretical results, we verify that our proposed optical manipulation technique is useful for the manipulation of biological cells.

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Apiletti, Daniele, Giulia Bruno, Elisa Ficarra, and Elena Baralis. "Data Cleaning and Semantic Improvement in Biological Databases." Journal of Integrative Bioinformatics 3, no. 2 (December 1, 2006): 219–29. http://dx.doi.org/10.1515/jib-2006-40.

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Summary Public genomic and proteomic databases can be affected by a variety of errors. These errors may involve either the description or the meaning of data (namely, syntactic or semantic errors). We focus our analysis on the detection of semantic errors, in order to verify the accuracy of the stored information. In particular, we address the issue of data constraints and functional dependencies among attributes in a given relational database. Constraints and dependencies show semantics among attributes in a database schema and their knowledge may be exploited to improve data quality and integration in database design, and to perform query optimization and dimensional reduction. We propose a method to discover data constraints and functional dependencies by means of association rule mining. Association rules are extracted among attribute values and allow us to find causality relationships among them. Then, by analyzing the support and confidence of each rule, (probabilistic) data constraints and functional dependencies may be detected. With our method we can both show the presence of erroneous data and highlight novel semantic information. Moreover, our method is database-independent because it infers rules from data. In this paper, we report the application of our techniques to the SCOP (Structural Classification of Proteins) and CATH Protein Structure Classification databases.

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Mao, Jingxin, Guowei Wang, Lin Yang, Lihong Tan, Cheng Tian, Lijing Tang, Ling Fang, Zhenqiang Mu, Zhaojing Zhu, and Yan Li. "Combined Network Pharmacology and Molecular Docking to Verify the Treatment of Type 2 Diabetes with Pueraria Lobata Radix and Salviae Miltiorrhizae Radix." Computational and Mathematical Methods in Medicine 2023 (February 11, 2023): 1–15. http://dx.doi.org/10.1155/2023/9150324.

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Objective. To explore the potential molecular mechanism of Pueraria Lobata Radix (RP) and Salviae Miltiorrhizae Radix (RS) in the treatment of type 2 diabetes mellitus (T2DM) based on network pharmacology and molecular docking. Methods. The chemical constituents and core targets of RP and RS were searched by Traditional Chinese Medicine System Pharmacology (TCMSP); target genes related to T2DM were obtained through GeneCards database, component target network diagram was constructed, intersection genes of active compounds and T2DM were synthesized, protein-protein interaction (PPI) relationship was obtained, and core targets were screened by using Cytoscape 3.7.2. Gene Ontology (GO) biological process and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were analyzed utilizing R studio 4.0.4 according to David database. Based on molecular docking, the screened active components of RP and RS were verified by molecular docking with the core target using Discovery Studio 2019. Results. There were totally 92 components and 29 corresponding targets in the component target network of RP and RS drug pair, of which 6 were the core targets of RP and RS in the treatment of T2DM. Molecular docking results showed that the active compounds of puerarin, formononetin, tanshinone iia, and luteolin had better binding activity with AKT1, VEGFA, NOS3, PPARG, MMP9, and VCAM1, respectively. Among them, puerarin showed significant effects in activating NOS3 pathway and luteolin exhibited significant effects in activating MMP9 pathway, respectively. The main biological processes mainly including xenobiotic stimulus, response to peptide, gland development, response to radiation, cellular response to chemical stress, response to oxygen levels, and the main signal pathways include response to xenobiotic stimulus, cellular response to chemical stress, response to peptide, gland development, and response to oxygen levels. Conclusion. Network pharmacology is an effective tool to explain the action mechanism of Traditional Chinese Medicine (TCM) from the overall perspective. RP and RS pair could alleviate T2DM via the molecular mechanism predicted by the network pharmacology, which provided new ideas and further research on the molecular mechanism of T2DM.

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Tao, J. J., P. Tandon, and V. W. Huang. "A151 COMPARABLE NEONATAL AND PREGNANCY-RELATED OUTCOMES BETWEEN EARLY AND LATE DISCONTINUATION OF BIOLOGICS IN PREGNANT WOMEN WITH INFLAMMATORY BOWEL DISEASE." Journal of the Canadian Association of Gastroenterology 4, Supplement_1 (March 1, 2021): 154–55. http://dx.doi.org/10.1093/jcag/gwab002.149.

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Abstract Background Inflammatory bowel disease (IBD) disease activity during pregnancy is related to adverse neonatal and pregnancy-related outcomes. Biologics are used to suppress disease activity, however, since there is known transplacental passage, the American Gastroenterology Association (AGA) recommends timing the final dose with drug-specific half-lives although there is little evidence demonstrating adverse outcomes. Aims We aim to assess the safety of early versus late discontinuation of biologics according to drug-specific half-lives by comparing various neonatal and pregnancy-related outcomes. Methods This is a REB approved single-center retrospective cohort study on all patients with IBD ≥18 years of age on a biologic agent prior to conception, have a documented final dose during pregnancy, and were seen at Mount Sinai Hospital from 2016–2019. Neonate and pregnancy-related outcomes were compared amongst the two groups (Table 1) using the student’s t-test (birthweight, gestational age, Apgar scores) and Fischer’s exact test (NICU admission, congenital anomalies, GBS, chorioamnionitis) analyzed in SPSS Version 27. The level of significance was set at p<0.05. Results We identified 53 patients on biologics pre-conception. 26 patients had a documented final dose (19 early cohort, 7 late cohort) and were included in the analysis. Aside from mean birthweight (3014 vs 3561 g, p=0.036), there were no statistically significant differences between the early and late cohorts for gestational age (37.4 vs 39.0 weeks, p=0.20), 1- and 5-min Apgar scores (7.8 vs 8.8, p=0.37 and 8.5 vs 9.0, p=0.49), NICU admissions (p=0.54), congenital anomalies (p=1.00), GBS (p=0.55), and chorioamnionitis (p=1.00). Conclusions Overall, our study suggests that early and late discontinuation of biologics have comparable safety profiles based on various neonatal and pregnancy-related outcomes. In fact, we see significantly higher birthweights in the late cohort along with a consistent (non-statistically significant) trend of later gestational ages, and higher Apgar scores. Further, no cases involving NICU admissions, congenital abnormalities, GBS, or chorioamnionitis were seen in the late cohort. Next, we hope to verify our findings by conducting a prospective cohort study with a larger study population and more comprehensive data collection. This will provide higher statistical power and allow for additional subgroup analyses based on objective disease activity (FCP levels) and therapeutic drug monitoring (serum drug levels). Funding Agencies None

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Wang, Shu Jing, Ning Chen, Zhang Yi, Jia Liu, and Bei Bei Xu. "Study on the Biological Activity of Anti-Tumor Peptide of Tumstatin." Advanced Materials Research 183-185 (January 2011): 1509–12. http://dx.doi.org/10.4028/www.scientific.net/amr.183-185.1509.

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Tumstatin anti-tumor peptide of 19peptide can inhibit the proliferation of melanoma cell. To study its effect on the proliferation and apoptosis of different tumor cells and verify its anti-tumor non-specificity, the base sequence of 19peptide was designed and constructed engineering bacteria. The soluble 19peptide was obtained from one step chitin affinity chromatograph. By such experiment as MTT assay, cell growth curve, TUNEL assay，flow cytometry，transmission electron microscopy(TEM), the biological activity of 19peptide was studied. Experiments in vitro identified that obtained 19peptide could inhibit proliferation of hela cell and hepatocarcinoma cell. It also could promote two tumor cells apoptosis. Its anti-tumor effect will lay foundation on its mechanism of action research and clinically tumor therapy in future.

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LAHAIE, PIERRE, J. R. SIMARD, J. MCFEE, S. BUTEAU, J. HO, P. MATHIEU, G. ROY, and V. LAROCHELLE. "SPECTRAL PROCESSING OF LASER-INDUCED FLUORESCENCE FROM THREATENING BIOLOGICAL AEROSOLS." International Journal of High Speed Electronics and Systems 18, no. 02 (June 2008): 429–43. http://dx.doi.org/10.1142/s0129156408005461.

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The stand-off detection classification by laser induced fluorescence is the objective of the Biosense project. The sensor will perform the monitoring of a defined area around its location using an elastic lidar detector for particles cloud. The detection of cloud will trigger fluorescence probing of the cloud. To perform this task the area fluorescence background will be monitored in order to evaluate if a return signal changed. Using a simple signal model built with experimental data, we designed a detection and monitoring procedure for the fluorescence at a single location. Signal simulations have been performed to verify the operation of the system. The results of the simulation indicate the system is able to detect anomaly with small contrast between a signal and the background. The results will have to be extended to area surveillance and a more complete signal model for various environments in natural conditions is required

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Liu, Guo Dong, Xi Ying Hao, and Hu Xu. "The Design and Simulated Analysis of Sheath Flow System for the Flow Cytometry." Applied Mechanics and Materials 703 (December 2014): 254–57. http://dx.doi.org/10.4028/www.scientific.net/amm.703.254.

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Flow cytometry is a examination method which can analyse and sort unicellular or biological particles . For the requirement of the width and the flowage of sample flow in the laser detection area , this paper designs a sheath flow system of flow cytometry through solidworks software based on the theory of hydrodynamic focusing. Simulating and calculating this model through solidworks flow simulation software, the simulated results meet fully the actual experiment for unicellular and biological particles. The simulated results can verify the correctness of the sheath flow system, and it has certain theoretical significance for actual design of sheath system about flow cytometry.

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Journal articles on the topic 'Verità biologica'

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