Relevant bibliographies by topics / Vecuronium

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Academic literature on the topic 'Vecuronium'

Author: Grafiati
Published: 4 June 2021
Last updated: 3 February 2022

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Journal articles on the topic "Vecuronium"

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Wright, Peter M. C., Paul Hart, Marie Lau, Ronald Brown, Manohar L. Sharma, Larry Gruenke, and Dennis M. Fisher. "The Magnitude and Time Course of Vecuronium Potentiation by Desflurane Versus Isoflurane." Anesthesiology 82, no. 2 (February 1, 1995): 404–11. http://dx.doi.org/10.1097/00000542-199502000-00011.

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Background Preliminary studies suggest that desflurane and isoflurane potentiate the action of muscle relaxants equally. However, variability between subjects may confound these comparisons. A crossover study was performed in volunteers on the ability of desflurane and isoflurane to potentiate the neuromuscular effect of vecuronium, to influence its duration of action, and on the magnitude and time course of reversal of potentiation when anesthesia was withdrawn. Methods Adductor pollicis twitch tension was monitored in 16 volunteers given 1.25 MAC desflurane on one occasion, and 1.25 MAC isoflurane on another. In eight subjects, vecuronium bolus dose potency was determined using a two-dose dose-response technique; the vecuronium infusion dose requirement to achieve 85% twitch depression also was determined. Also in these subjects, the magnitude and time course of spontaneous neuromuscular recovery were determined when the anesthetic was withdrawn while maintaining a constant vecuronium infusion. In the other eight subjects, the time course of action of 100 micrograms/kg vecuronium was determined. Results Vecuronium's ED50 and infusion requirement to maintain 85% twitch depression were 20% less during desflurane, compared to isoflurane, anesthesia; vecuronium plasma clearance was similar during the two anesthetics. After 100 micrograms/kg vecuronium, onset was faster and recovery was longer during desflurane anesthesia. When the end-tidal anesthetic concentration was abruptly reduced from 1.25 to 0.75 MAC, twitch tension increased similarly (approximately 15% of control), and time for the twitch tension to reach 90% of the final change was similar (approximately 30 min) with both anesthetics. Decreasing anesthetic concentration from 0.75 to 0.25 MAC increased twitch tension by 46 +/- 10% and 25 +/- 7% of control (mean +/- SD, P < 0.001) with desflurane and isoflurane, respectively; 90% response times for these changes were 31 +/- 10 min and 18 +/- 7 min (P < 0.05), respectively. Conclusions Desflurane potentiates the effect of vecuronium approximately 20% more than does an equipotent dose of isoflurane.
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Fisher, Dennis M., Janos Szenohradszky, Peter M. C. Wright, Marie Lau, Ronald Brown, and Manohar Sharma. "Pharmacodynamic Modeling of Vecuronium-induced Twitch Depression." Anesthesiology 86, no. 3 (March 1, 1997): 558–66. http://dx.doi.org/10.1097/00000542-199703000-00007.

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Background After bolus doses of nondepolarizing muscle relaxants, the adductor pollicis recovers from paralysis more slowly than the diaphragm and the laryngeal adductors, suggesting that the adductor pollicis is more sensitive than the respiratory muscles to effects of those drugs. In contrast, during onset, the respiratory muscles are paralyzed more rapidly than the adductor pollicis, suggesting that the respiratory muscles are more sensitive than the adductor pollicis. To reconcile these apparently conflicting findings, we determined vecuronium's pharmacokinetics and its pharmacodynamics at both the adductor pollicis and the laryngeal adductors. Methods Six volunteers were studied on two occasions during anesthesia with propofol. Mechanical responses to train-of-four stimulation were measured at the adductor pollicis and at the laryngeal adductors. Vecuronium (15-60 micrograms/kg) was given and arterial plasma samples were obtained from 0.5-60 min. Vecuronium doses differed by twofold on the two occasions. A pharmacokinetic model accounting for the presence and potency of vecuronium's 3-desacetyl metabolite and a sigmoid e-max pharmacodynamic model were fit to the resulting plasma concentration and effect (adductor pollicis and laryngeal adductors) data to determine relative sensitivities and rates of equilibration between plasma and effect site concentrations. Results The steady-state plasma concentration depressing laryngeal adductor twitch tension by 50% was approximately 1.5 times larger than that for the adductor pollicis. The equilibration rate constant between plasma and laryngeal adductor concentrations was about 1.5 faster than that between plasma and adductor pollicis concentrations. The Hill factor (gamma) that describes the steepness of the laryngeal adductor concentration-effect relation was approximately 0.6 times that of the adductor pollicis. Conclusions More rapid equilibration between plasma and laryngeal adductor vecuronium concentrations explains why onset is more rapid at the laryngeal adductors than at the adductor pollicis. During recovery, both rapid equilibration and lesser sensitivity of the laryngeal adductors contribute to earlier recovery.
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Stirt, Joseph A., William Maggio, Charles Haworth, Michael D. Minton, and Robert F. Bedford. "Vecuronium." Anesthesiology 67, no. 4 (October 1, 1987): 570–72. http://dx.doi.org/10.1097/00000542-198710000-00022.

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Wright, Peter M. C., Gerald McCarthy, Janos Szenohradszky, Manohar L. Sharma, and James E. Caldwell. "Influence of Chronic Phenytoin Administration on the Pharmacokinetics and Pharmacodynamics of Vecuronium." Anesthesiology 100, no. 3 (March 1, 2004): 626–33. http://dx.doi.org/10.1097/00000542-200403000-00024.

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Background The duration of action of vecuronium is reduced in patients receiving phenytoin. In this study, the authors examined, simultaneously, the influence of phenytoin on both the pharmacokinetics and the pharmacodynamics of vecuronium. Methods This study was approved by the institutional review board of the University of California, San Francisco, and patients gave written informed consent. Twenty-two patients, 11 taking phenytoin and all scheduled to undergo prolonged neurosurgical procedures with general anesthesia, participated in the study. In 12 patients (6 phenytoin, 6 control), vecuronium was infused at 7.5 microg x kg(-1) x min(-1) until the first response (T1) of each train-of-four decreased by 50%; in the remaining 10 patients (5 phenytoin, 5 control), 200 microg/kg vecuronium was infused over 10 min. Arterial blood samples were drawn at intervals over the next 5-7 h. Plasma concentrations of vecuronium and 3-desacetylvecuronium were measured by capillary gas chromatography. Pharmacokinetic and pharmacodynamic modeling was used to characterize the disposition of vecuronium and patient responses to it in the two groups. Results Clearance was typically increased by 138% (95% confidence interval, 93-183%) in patients taking phenytoin. The effect of vecuronium was well described using a sigmoid Emax model. The concentration of vecuronium giving 50% twitch depression was increased 124% (45-202%) in patients taking phenytoin. Conclusions Chronic phenytoin therapy reduces the effect of vecuronium by mechanisms that include both increased vecuronium metabolism and reduced sensitivity of the patient to circulating concentrations of vecuronium.
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Blobner, Manfred, Eberhard Kochs, Heidrun Fink, Barbara Mayer, Andreas Veihelmann, Thomas Brill, and Josef Stadler. "Pharmacokinetics and Pharmacodynamics of Vecuronium in Rats with Systemic Inflammatory Response Syndrome." Anesthesiology 91, no. 4 (October 1, 1999): 999. http://dx.doi.org/10.1097/00000542-199910000-00020.

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Background Insufficient detoxification caused by nitric oxide-related inhibition of cytochrome P450 may be important for metabolism of numerous drugs, including vecuronium. The present study investigated the pharmacodynamics and pharmacokinetics of vecuronium in rats with inflammatory liver dysfunction. Methods Male Sprague-Dawley rats (n = 56) were randomly allocated into two groups: In the sepsis group, liver inflammation was established by injection of 56 mg/kg heat-killed Corynebacterium parvum; control rats received the solvent. At day 4, groups were subdivided according to treatment with the nitric oxide synthase inhibitor N(G)-monomethyl-L-arginine (250 mg/kg) or placebo. The aminopyrine breath test was performed to assess cytochrome P450 activity. Rats were anesthetized with propofol and mechanically ventilated. Duration of action of vecuronium (1.2 mg/kg) was measured by evoked mechanomyography (stimulation of the sciatic nerve, contraction of the gastrocnemius muscle). In seven rats of each subgroup a 50% neuromuscular blockade was established by a continuous vecuronium infusion. Vecuronium plasma levels were measured and plasma clearance of vecuronium was calculated. Nitric oxide synthesis was assessed by measuring nitrite/nitrate serum levels. Results In sepsis/placebo rats, vecuronium-induced neuromuscular blockade was prolonged (144% of contro/placebo), vecuronium plasma levels at 50% neuromuscular blockade were increased (122% of control/placebo), and plasma clearance was decreased (68% of control/placebo). N(G)-monomethyl-L-arginine therapy in rats with sepsis improved cytochrome P450 activity and plasma clearance of vecuronium, shortened duration of action of vecuronium, but did not alter the elevated vecuronium plasma levels. Conclusions A systemic inflammatory response syndrome with liver dysfunction results in decreased sensitivity to and a decreased elimination of vecuronium. Modulation of nitric oxide synthesis may be a strategy that can be used in the future to improve xenobiotic metabolism in sepsis.
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&NA;. "Vecuronium bromide see Fentanyl/halothane/vecuronium bromide." Reactions Weekly &NA;, no. 367 (September 1991): 12. http://dx.doi.org/10.2165/00128415-199103670-00063.

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Beaufort, Ton M., Johannes H. Proost, Jan-Gerard Maring, Emiel R. Scheffer, J. Mark K. H. Wierda, and Dirk K. F. Meijer. "Effect of Hypothermia on the Hepatic Uptake and Biliary Excretion of Vecuronium in the Isolated Perfused Rat Liver." Anesthesiology 94, no. 2 (February 1, 2001): 270–79. http://dx.doi.org/10.1097/00000542-200102000-00017.

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Background Hypothermia prolongs the time course of action of nondepolarizing muscle relaxants. It is not known whether this prolongation is caused by a reduced rate of extrahepatic distribution or elimination, liver uptake, metabolic clearance, or biliary excretion. Therefore, the authors studied the effects of hypothermia on the net hepatic uptake, metabolism, and biliary excretion of vecuronium in isolated perfused rat liver. Methods Livers of Wistar rats were perfused with Krebs Ringer solution (1% albumin, 3.3% carbon dioxide in oxygen, pH 7.36-7.42, 38 degrees C). Each perfusion experiment (recirculatory perfusion system) was divided into three phases. In phase 1, a bolus dose of vecuronium (950 microg) was followed by a continuous infusion of vecuronium (63 microg/min) throughout the perfusion experiment. In phase 2, the temperature was reduced to 28 degrees C. In phase 3, temperature was restored. In controls, the temperature was kept constant throughout the perfusion. Concentrations of vecuronium and its metabolites were measured in perfusion medium, bile, and liver homogenate. Parameters of a multicompartmental liver model were fitted to the concentration patterns in perfusion medium and in bile. Results Hypothermia increased vecuronium concentrations in the perfusion medium from 4.0 microg/ml (range, 2.5-6.6) to 15.6 microg/ml (11.5-18.4 microg/ml; P = 0.018). Hypothermia reduced the biliary excretion rate of 3-desacetyl vecuronium from 18% (range, 6-37%) to 16% (range, 4-19%) of that of vecuronium (P = 0.018). Pharmacokinetic analysis confirmed that hypothermia reduced the rate constants of hepatic uptake and metabolism from 0.219 to 0.053 and from 0.059 to 0.030, respectively. Conclusions Hypothermia significantly and reversibly reduced the net hepatic uptake of vecuronium. Hypothermia reduced the metabolism of vecuronium and the biliary excretion rate of 3-desacetyl vecuronium.
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&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 1016 (August 2004): 18. http://dx.doi.org/10.2165/00128415-200410160-00061.

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&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 299 (May 1990): 11. http://dx.doi.org/10.2165/00128415-199002990-00054.

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&NA;. "Vecuronium bromide." Reactions Weekly &NA;, no. 300 (May 1990): 12. http://dx.doi.org/10.2165/00128415-199003000-00049.

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Dissertations / Theses on the topic "Vecuronium"

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Nützel, Jakob. "Präkurarisierung mit Vecuronium inhibiert die Succinylcholinwirkung dosisabhängig." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963770780.

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SEGREDO, VERONICA. "Curarisation prolongee apres administration de vecuronium au long cours en reanimation." Nantes, 1992. http://www.theses.fr/1992NANT060M.

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Senotier, Jean-Marc. "Intubation rapide et curares non dépolarisants : contribution à l'étude du "priming" avec le vecuronium." Nantes, 1986. http://www.theses.fr/1986NANT3520.

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Dinsmore, Kristen G., Bethany Campbell, Timothy Archibald, Greg Mosier, Stacy D. Brown, and Alexei Gonzalez-Estrada. "Refrigerated Stability of Diluted Cisatracurium, Rocuronium, and Vecuronium for Skin Testing after Perioperative Anaphylaxis." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etsu-works/5266.

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RATIONALE: The purpose of this study is to investigate the stored stability of dilutions of neuromuscular blocking agents (NMBAs), namely cisatracurium, rocuronium, and vecuronium, for skin prick/intradermal testing. METHODS: Concentrations of NMBAs were monitored by liquid chromatography-mass spectrometry (LC-MS/MS) for a period of 14 days. Dilutions of NMBAs were prepared in saline by factors of 10x, 100x, 1,000x, and 100,000x as sensitivity of the assay allowed. Diluted drug products were stored in a laboratory refrigerator until sampling. On sampling days, aliquots of each dilution were removed and compared to a freshly prepared set of reference dilutions. RESULTS: The results are measured as beyond use date (BUD) defined as recovery of drug versus the reference (90-110%). Based on the LC-MS/MS data, the BUD for cisatracurium diluted to 10x and 100x is 96 hours. Higher dilutions (1,000x to 100,000x) should be used immediately following preparation (within less than 24 hours). Vecuronium at 10x and 100x also has a BUD of 96 hours, and the 1,000x dilution is stable for 24 hours. The 10,000x dilution should be used immediately. Rocurium at 10x to 1,000x has a BUD of 48 hours, yet higher dilutions (10,000x and 100,000x) should be used immediately. CONCLUSIONS: With increasing dilution factors, the stability of these drugs in saline decreases, increasing deviation between samples and references. The most stable dilutions for each of the drugs tested were 10x and 100x. Stability of these drugs is likely compromised by hydrolysis of the ester bonds in the drug molecules.
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Dinsmore, Kristen, Bethany Campbell, Timothy Archibald, Greg Mosier, Stacy PhD Brown, and Alexei MD Gonzalez-Estrada. "Refrigerated Stability of Diluted Cisatracurium, Rocuronium, and Vecuronium for skin testing after perioperative anaphylaxis." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/146.

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Rationale: The purpose of this study is to investigate the stored stability of dilutions of neuromuscular blocking agents (NMBAs), namely cisatracurium, rocuronium, and vecuronium, for skin prick/intradermal testing. Methods: Concentrations of NMBAs were monitored by liquid chromatography-mass spectrometry (LC-MS/MS) for a period of 14 days. Dilutions of NMBAs were prepared in saline by factors of 10x, 100x, 1,000x, 10,000x, and 100,000x as sensitivity of the assay allowed. Diluted drug products were stored in a laboratory refrigerator until sampling. On sampling days, aliquots of each dilution were removed and compared to a freshly prepared set of reference dilutions. Results: The results are measured as beyond use date (BUD) defined as recovery of drug versus the reference (90-110%). Based on the LC-MS/MS data, the BUD for cisatracurium diluted to 10x and 100x is 96 hours. Higher dilutions (1,000x to100,000x) should be used immediately following preparation (within less than 24 hours). Vecuronium at 10x and 100x, also has a BUD of 96 hours, and the 1,000x dilution is stable for 24 hours. The 10,000x dilution should be used immediately. Rocuronium at 10x to 1,000x has a BUD of 48 hours, yet higher dilutions (10,000x and 100,000x) should be used immediately. Conclusions: With increasing dilution factors, the stability of these drugs in saline decreases, increasing deviation between samples and references. The most stable dilutions for each of the drugs tested were 10x and 100x. Stability of these drugs is likely compromised by hydrolysis of the ester bonds in the drug molecules.
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Wyon, Nicholas. "On the interaction between a neuromuscular blocking agent and regulation of breathing during hypoxia /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-659-6.

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Castillejo, Correa Julio César. "Evaluación de secuencia inversa con vecuronio en pacientes sometidos a anestesia general." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2004. https://hdl.handle.net/20.500.12672/1777.

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EVALUACIÓN DE SECUENCIA INVERSA CON VECURONIO EN PACIENTES SOMETIDOS A ANESTESIA GENERAL EN EL HOSPITAL GUILLERMO ALMENARA IRIGOYEN. Dr. Julio César Castillejo Correa Hospital Guillermo Almenara Irigoyen. UNMSM Objetivo: Determinar como influye la secuencia de administración de Vecuronio en el tiempo, para lograr condiciones adecuadas de intubación en pacientes que reciben anestesia general. Metodología: Se diseño un estudio Experimental (Ensayo clínico), Prospectivo, Analítico, Longitudinal, Tipo Cohorte. La muestra incluyó 200 pacientes, que cumplieron los criterios de inclusión y fueron divididos al azar en dos grupos: Grupo 1: Inducción de secuencia normal (Propofol - Vecuronio) Grupo 2: Inducción de secuencia inversa (Vecuronio - Propofol) Con ayuda de un observador quien registraba los datos de la monitorización y otro (el mismo en todos los casos) realizaba la intubación. Las condiciones de intubación fueron evaluadas mediante la escala de Damoal-Mehta modificada. La intubación endotraqueal se realizó de acuerdo a las condiciones clínicas del paciente monitorizado y en correlación a un estimulador de nervio periférico con acelerómetro (TOF- GUARD). Se utilizo el programa Epi - Info 2000. Resultados: Ambos grupos de estudio fueron comparables para edad, sexo, estado físico (ASA) y condiciones de intubación. La técnica de inducción con secuencia inversa (Vecuronio 0.15 mg/Kg durante 20 seg, 20 seg después se aplicó Propofol 2 mg/Kg durante 20 seg), es capaz de producir condiciones adecuadas de intubación en menor tiempo (28 seg promedio), en comparación con la secuencia normal de inducción (Propofol 2 mg/Kg durante 20 seg, 20 seg después se aplicó Vecuronio 0.15 mg/Kg durante 20 seg) que logró adecuadas condiciones de intubación en 101 seg promedio. Se apreció una reducción del tiempo de 73% al compararse ambas secuencias de inducción. Se dio el menor tiempo en lograr adecuadas condiciones de intubación (18 seg) en una paciente de sexo femenino, de 21 años y ASA I, que fue inducida con secuencia inversa. Se comprobó que con la técnica de secuencia inversa se dieron mínimas variaciones hemodinámicas (frecuencia cardiaca, presión arterial sistólica y diastólica). La medida de relajación muscular por neuroestimulador (TOF), corroboró que los pacientes del estudio sometidos a inducción con secuencia inversa (56.043%) y secuencia normal (58.86%), presentaron porcentajes semejantes de relajación, logrando el grupo de secuencia inversa menos tiempo para alcanzar estos valores. Las condiciones de intubación no mostraron diferencias significativas entre ambos grupos. Todos los pacientes tuvieron condiciones buenas y excelentes al momento de intubar. Conclusión: La inducción de secuencia inversa produce condiciones adecuadas de intubación en un menor tiempo, que la inducción con secuencia normal, resultando esta técnica eficiente en acortar el periodo entre la administración del agente de inducción y la intubación (Inicio de acción del relajante), observándose que al administrar la dosis completa de intubación del relajante muscular antes del inductor, se gana algunos segundos en el periodo en que el paciente permanece inconsciente y sin aislar la vía aérea. Palabras Clave: Secuencia Inversa, secuencia normal, TFIT
-- EVALUATION OF THE INVERSE SEQUENCE WITH VECURONIO IN PATIENTS SUBMITED TO GENERAL ANESTHESIA IN THE GUILLERMO ALMENARA IRIGOYEN´S HOSPITAL. Julio César Castillejo Correa Hospital NacionalGuillermo Almenara Irigoyen. UNMSM Objective: Determine how the administration sequence of Vecuronio influences in time, to reach suitable conditions for intubation in patients that receive general anesthesia. Methodology: A experimental study (clinical rehearsal), prospective, analític, longitudinal, Cohort type. The sample include 200 patients, that obeyed the inclusion criteria and they were divided at random in two groups: Group 1: normal- sequence Induction (Propofol - Vecuronio) Group 2: inverse- sequence Induction (Vecuronio - Propofol) With an observer's help that was registering the monitorization's data and another one (the same one in all cases) perform the intubation. The intubation conditions were evaluated with the Damoal's - Mehta scale modified. The endotraqueal intubation were realize according to the clinical conditions of the patient and in correlation to a peripheric- nerve stimulator with accelerometer (TOF - GUARD). We use Epi - Info 2000 program. Results: Both study groups were comparable for age, sex, physical state (ASA) and intubation conditions. The induction technique with inverse sequence (Vecuronio 0.15 mg/Kg during 20 sec, 20 sec after, Propofol applied 2 mg/Kg during 20 sec), is able to produce suitable intubation conditions in less time (28 sec average), as compared with the normal induction sequence (Propofol 2 mg/Kg during 20 sec, 20 sec after, Vecuronio applied 0.15 mg/Kg during 20 sec) that obtain suitable intubation conditions in 101sec average. A time reduction of 73% was appreciated when both sequences were compared. We obtain the less time in produce suitable intubation conditions (18 sec) in a patient of female sex, of 21 years, ASA I, that was induced with inverse sequence. We checked that with the inverse-sequence technique appears minimal hemodinamics variations (cardiac frequency, blood pressure sistolic and diastolic). The measure of the muscular relaxation by neuroestimulator (TOF), corroborated that the study's patients submit to induction with inverse sequence (56.043%) and normal sequence (58.86%), presented similar relaxation percentages, achieving the inverse-sequence group less time to reach these values. The intubation conditions not shows significant differences among both groups. All of the patients had good and excellent conditions at the moment of the intubation.. Conclusion: The inverse- sequence induction produces suitable conditions of intubation in a less time, than the induction with normal sequence, resulting this technique efficient in shortening the period among the administration of the agent of induction and the intubation (start of the relaxant's action), observing that when we administrate the complete intubation dose of the muscular relaxant before the inductor, the patient wins some seconds in the period whereon remain unconscious and without isolating airway. Key words: Inverse Sequence, normal sequence, TFIT
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Early, Marvin E. "Comparison of Succinylcholine Induced Fasciculation Attenuation with Defasciculating Doses of Vecuronium and Mivacurium Based on Ideal Body Weight." VCU Scholars Compass, 1993. http://scholarscompass.vcu.edu/etd/4548.

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This study was conducted to determine if Mivacurium (Miv) was as effective as Vecuronium (Vec) in attenuating Succinylcholine (Sch)-induced fasciculations with muscle relaxant doses based upon ideal body weight (IBW). A quasi experimental design was used to study 60 patients who were randomly assigned to one of three groups. The two study groups were compared to a control group and each other with regards to the incidence and intensity of fasciculations. Either Vec (0.01 mg/kg (IBW)), Miv (0.02 mg/kg (IBW)), or saline (control) was administered in a double-blinded manner 3 minutes prior an intubating dose of Sch (IBW). Both pretreatment modalities resulted in a significant (p < .05) decrease in the incidence (Vec 40%, Miv 60%) and intensity of fasciculations when compared to saline (90%). No significant differences (p > .05) were found between the two pretreatment groups with regards to the incidence and intensity of fasciculations. It was concluded that Miv 0.02 mg/kg (IBW) attenuated Sch-induced fasciculations with the same efficacy as Vec 0.01 mg/kg (IBW).
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Kellner, Bernhard [Verfasser], Jürgen [Akademischer Betreuer] Schüttler, Jürgen [Gutachter] Schüttler, and Carla [Gutachter] Nau. "Die Muskelrelaxanzien Rocuronium, Vecuronium, Pancuronium, Atracurium und Succinylcholin aktivieren TRPA1 - und TRPV1 - Rezeptoren nozizeptiver Neurone / Bernhard Kellner ; Gutachter: Jürgen Schüttler, Carla Nau ; Betreuer: Jürgen Schüttler." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2020. http://d-nb.info/1204257841/34.

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Wiederkehr, Heinz. "Verteilung, Ausscheidung und Metabolismus von C-14-Vecuronium-Bromid nach i.v.-Applikation bei der Ratte : Beiträge zur Aufklärung der Pharmakokinetik und des Metabolismus eines Pancuronium-Analogon /." Zürich, 1985. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=7920.

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Books on the topic "Vecuronium"

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Hunter, Jennifer M., and Thomas Fuchs-Buder. Neuromuscular blockade and reversal. Edited by Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0016.

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Over the past 70 years since the introduction of d-tubocurarine, the search for an ideal neuromuscular blocking agent has led to the development of the depolarizing drug, succinylcholine (suxamethonium), with its rapid onset of action and plasma metabolism, and a series of non-depolarizing agents of which there are two groups: benzylisoquinoliniums (e.g. atracurium, cisatracurium and mivacurium) and aminosteroidal agents (e.g. pancuronium, vecuronium and rocuronium). The need to monitor neuromuscular block perioperatively to ensure the appropriate dose of any neuromuscular blocking drug is given has led to the development of several nerve stimulation techniques. Particularly useful clinically are the train-of-four twitch response, double-burst stimulation, and the post-tetanic count. Their benefits and limitations are considered in this chapter. The most suitable equipment to monitor neuromuscular block and the appropriate anatomical sites for stimulation are discussed. To prevent residual block with its pathophysiological consequences such as upper airway and pharyngeal dysfunction and potential respiratory failure at the end of surgery, antagonizing agents are used. These are of two types: anticholinesterases such as neostigmine and edrophonium, and the γ‎-cyclodextrin, sugammadex. The pharmacodynamics and pharmacokinetics of neuromuscular blocking drugs and their antagonists are altered by the extremes of age, obesity, and several disease states including renal and hepatic failure, neuromuscular disorders, and critical illness. The altered response to all these drugs in these pathologies, which is related to their metabolism and excretion, is considered in detail, together with their other side-effects including the particular disadvantages to the use of succinylcholine.
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Book chapters on the topic "Vecuronium"

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Miller, R. D. "Vecuronium (ORG-NC-45)." In New Neuromuscular Blocking Agents, 617–27. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70682-0_28.

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Bowman, W. C., and G. A. Sutherland. "Vecuronium (ORG-NC-45)." In New Neuromuscular Blocking Agents, 419–43. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-70682-0_18.

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Meretoja, Olli A., Larisa Jalkanen, Tomi Taivainen, Barbara W. Brandom, and Bimal Dayal. "Synergism Between Atracurium and Vecuronium with Mivacurium." In Muscle Relaxants, 361. Tokyo: Springer Japan, 1995. http://dx.doi.org/10.1007/978-4-431-66896-1_62.

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Ottermann, U., and H. J. Schröder. "Interaktion von Vecuronium und Pancuronium — Klinische elektromyographische Untersuchungen." In Aktueller Stand der klinischen Anaesthesie, 163–72. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71229-6_28.

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5

Okuyama, Atsushi, Koichi Takita, and Osamu Kemmotsu. "The Duration of Vecuronium Action Shortened After Kidney Transplantation." In Muscle Relaxants, 386. Tokyo: Springer Japan, 1995. http://dx.doi.org/10.1007/978-4-431-66896-1_87.

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Redl, G., S. Schlöglhofer, C. K. Spiss, R. Riegler, J. Neumark, and V. Draxler. "Kombinationsanästhesie mit Propofol, Alfentanil und Vecuronium für mikrolaryngoskopische Eingriffe." In ZAK München 1987, 77–84. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73573-8_12.

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Schultz, M., W. Friesdorf, T. Fösel, and K. H. Altemeyer. "Pharmakodynamik von Vecuronium beim Kleinkind nach intravenöser Narkoseeinleitung mit Ketamin." In Spezielle Anaesthesieprobleme, 183–88. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71281-4_29.

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8

Nöldge, G., N. Krieg, G. Schomburg, B. Baumann, and K. L. Scholler. "Influence of Isoflurane on Muscle Relaxation with Vecuronium in Clinical Anesthesia." In Isoflurane, 83–86. Berlin, Heidelberg: Springer Berlin Heidelberg, 1986. http://dx.doi.org/10.1007/978-3-642-71230-2_15.

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Okuyama, Atsuki, Koichi Takita, Yukiko Goda, Hiroshi Kawahigashi, and Osamu Kemmotsu. "Hyperparathyroidism in Patients with Chronic Renal Failure Shortens the Action of Vecuronium." In Muscle Relaxants, 400. Tokyo: Springer Japan, 1995. http://dx.doi.org/10.1007/978-4-431-66896-1_101.

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Kansanaho, Maija, and Klaus T. Olkkola. "Quantifying the Effect of Enflurane on Infusion Requirements of Atracurium and Vecuronium." In Muscle Relaxants, 404. Tokyo: Springer Japan, 1995. http://dx.doi.org/10.1007/978-4-431-66896-1_105.

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Conference papers on the topic "Vecuronium"

1

McDaniel, Sullivan, Zhang, Hogan, and Wagner-Mann. "Influence Of Vecuronium Bromide On The ED50 For Electrical Ventricular Defibrillation In The Canine Model." In Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1992. http://dx.doi.org/10.1109/iembs.1992.595773.

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McDaniel, W. C., M. Sullivan, Q. Zhang, M. Hogan, and C. Wagner-Mann. "Influence of Vecuronium Bromide on the ED50 for electrical ventricular defibrillation in the canine model." In 1992 14th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 1992. http://dx.doi.org/10.1109/iembs.1992.5761160.

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You might also be interested in the extended bibliographies on the topic 'Vecuronium' for particular source types:
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