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Relevant bibliographies by topics / Vector viruses / Dissertations / Theses

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Dissertations / Theses on the topic 'Vector viruses'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 February 2022

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1

Jones, Taylor J. "Grapevine Viruses and Associated Vectors in Virginia: Survey, Vector Management, and Development of Efficient Grapevine Virus Testing Methods." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/81460.

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In order to aid the booming wine industry in the state of Virginia, U.S.A., we developed a series of studies to provide a deeper understanding of the viruses and vectors for management of virus diseases and development of better tools for grapevine virus diagnostics. A statewide survey for 14 different grapevine viruses between 2009 and 2014 was conducted: 721 samples were collected from 116 vineyards in the period. Among the 12 viruses identified, Grapevine leafroll associated virus-3 (GLRaV-3), Grapevine rupestris stem-pitting associated virus (GRSPaV), and Grapevine red blotch-associated vi

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2

Grzybowski, Brad. "A pseudotyped viral vector : hPIV3-HIV-1." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/20932.

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3

Uzcategui, Cuello Nathalie Yumari. "Evolution and dispersal of mosquito-borne flaviviruses." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288520.

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4

Davis, Adam James. "Transcriptional analysis of human immunodeficiency virus type 1 infection following cell-to-cell transmission /." Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phd2609.pdf.

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5

Cagney, Gerard Michael. "Development of a bovine enterovirus expression vector." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295404.

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6

Gouge, Dawn H., James R. Hagler, Shaku Nair, et al. "Human Disease Causing Viruses Vectored by Mosquitoes." College of Agriculture, University of Arizona (Tucson, AZ), 2017. http://hdl.handle.net/10150/625572.

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7 p.<br>There are a number of disease-causing viruses transmitted to people primarily through the bite of infected mosquitoes. Female mosquitoes take blood meals to produce eggs. A mosquito that bites an infected animal may pick up a virus within the blood meal. If the mosquito is the appropriate species, and conditions inside the insect and the surrounding environment are supportive, the virus reproduces within the mosquito. Later, the mosquito may pass the virus on to other animals (including humans) as they feed again.

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7

Reddy, R. V. Chowda. "Molecular characterisation of tomato leaf curl viruses and their vector, Bemisia tabaci." Thesis, University of Greenwich, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401568.

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8

Ramasamy, Parthiban Aravindh Babu. "Development of vector based FMD vaccines for increasing immune response against FMDV." Thesis, Royal Veterinary College (University of London), 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.559070.

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9

Al-Mrabeh, Ahmad. "Aphid-borne viruses of potato : investigations into virus/host/vector interactions, serological detection using recombinant antibodies and control strategies." Thesis, University of Newcastle Upon Tyne, 2011. http://hdl.handle.net/10443/1181.

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Potato is one of the most important food crops in the world, and viruses are largely responsible for the degeneration of this vegetatively propagated crop. At least 35 viruses have been reported to infect potato naturally. The majority and the most economically important ones are vectored by aphids. The objective of this study was to conduct molecular and biological investigations into virus transmission mechanisms, including developing diagnostic methods to help to control the spread of aphid-borne potato viruses, and disrupting the vectoring ability of their aphid vectors by insecticide spra

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10

Turrell, Susan. "Development of Herpesvirus saimiri as a cancer gene therapy vector : production of 2 recombinant viruses." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534844.

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11

Fosu-Nyarko, John. "Studies on Subterranean clover mottle virus towards development of a gene silencing vector." Fosu-Nyarko, John (2005) Studies on Subterranean clover mottle virus towards development of a gene silencing vector. PhD thesis, Murdoch University, 2005. http://researchrepository.murdoch.edu.au/54/.

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Subterranean clover mottle virus (SCMoV) is a positive sense, single-stranded RNA virus that infects subterranean clover (Trifolium subterraneum) and a number of related legume species. The ultimate aim of this research was to investigate aspects of SCMoV that would support its use as a gene silencing vector for legume species, since RNA (gene) silencing is now a potential tool for studylng gene function. The ability of viruses to induce an antiviral defense system is being explored by virus-induced gene silencing (VIGS), in which engmeered viral genomes are used as vectors to introduce genes

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12

au, J. Fosu@murdoch edu, and John Fosu-Nyarko. "Studies on Subterranean clover mottle virus towards development of a gene silencing vector." Murdoch University, 2005. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20050421.123457.

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Subterranean clover mottle virus (SCMoV) is a positive sense, single-stranded RNA virus that infects subterranean clover (Trifolium subterraneum) and a number of related legume species. The ultimate aim of this research was to investigate aspects of SCMoV that would support its use as a gene silencing vector for legume species, since RNA (gene) silencing is now a potential tool for studylng gene function. The ability of viruses to induce an antiviral defense system is being explored by virus-induced gene silencing (VIGS), in which engmeered viral genomes are used as vectors to introduce genes

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13

Baldridge, Gerald Don. "Molecular biology of Bunyavirus-host interactions." Diss., The University of Arizona, 1989. http://hdl.handle.net/10150/184934.

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Ribonuclease T1 oligonucleotide fingerprint (ONF) analysis was used to study genomic stability of La Crosse virus (Bunyaviridae) during vertical and horizontal transmission in the laboratory. No RNA genomic changes were detected in vertebrate cell culture-propagated virus isolated (following oral ingestion and replication) from the natural mosquito host, Aedes triseriatus. Genomic changes were not detected during transovarial passage of virus through two generations of mosquitoes or in virus isolated from suckling mice infected by transovarially infected mosquitoes. These results demonstrate t

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14

Gelinas, Jean-Francois. "Enhancement of lentiviral vector production through alteration of virus-cell interactions." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:9921b8b4-e2b5-4eec-9efc-6036765c8d55.

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Gene therapy is the introduction or alteration of genetic material with the intention to treat disease. To support this aim, viruses have been modified, with elements linked to viral pathogenicity removed from their genome and replaced by the genetic material to be delivered. Gene therapy vectors based on lentiviruses have many advantages, such as the ability to transduce non-dividing cells and to target specific cell types via pseudotyping. They have been successfully used in ex vivo clinical trials for several haematopoietic stem cell disorders. Lentiviral vectors, however, suffer from subst

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15

Alharbi, Naif K. "New approaches for improving the immunogenicity of modified vaccinia virus Ankara as a recombinant vaccine vector." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:bbde86fd-ea8f-4e66-b260-f923d7e01e4b.

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16

Hadi, Buyung Asmara Ratna Flanders Kathy L. Bowen Kira L. "Aphid vectors and grass hosts of barley yellow dwarf virus and cereal yellow dwarf virus in Alabama and western Florida." Auburn, Ala., 2009. http://hdl.handle.net/10415/2018.

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17

Belhouchet, Mourad. "Analysis of an anti-silencing mechanism involved in immune evasion by vector-borne dsRNA animal viruses of family Reoviridae." Thesis, University of Oxford, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711672.

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18

Zhang, Lei [Verfasser], and Wilhelm [Akademischer Betreuer] Jelkmann. "Construction of infectious full-length cDNA clones of apple viruses and plant viral vector development / Lei Zhang ; Betreuer: Wilhelm Jelkmann." Heidelberg : Universitätsbibliothek Heidelberg, 2017. http://d-nb.info/1178010139/34.

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19

Balagué, Cabasés Eudald. "Teràpia gènica basada en un vector viral adenoassociat per al tractament d’un model de ratolí d’atàxia de Friedreich." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/671640.

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L’atàxia de Friedreich (FRDA) és una malaltia neurodegenerativa, hereditària autosòmica recessiva, causada per la deficiència de la proteïna frataxina (FXN) deguda a l’expansió patològica del triplet GAA intrònic en el gen FXN. Es caracteritza principalment per una atàxia progressiva, pèrdua sensorial i cardiomiopatia hipertròfica. La neurodegeneració s’identifica en les neurones dels DRG, els nervis sensorials perifèrics, les columnes posteriors i el nucli dentat cerebel·lós. En l’actualitat no existeix tractament, però diverses proves de concepte han evidenciat el potencial terapèutic de la

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20

Pearson, Frances E. "Transcutaneous delivery of T cell-inducing viral vector malaria vaccines by microneedle patches." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:2155c639-bcc8-49e0-b415-a5d353aacba3.

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There is an urgent need for improvements to existing vaccine delivery technologies to run parallel with the development of new-generation vaccines. The burdens of needle-based immunisation strategies are exacerbated by poor resource provision in such areas as sub-Saharan Africa, where annual malaria mortality stands at 860,000. Needle-free delivery of vaccine to the skin holds promise for improved immunogenicity with lower doses of vaccine, in addition to significant logistical advantages. Various methods have been described for the transcutaneous delivery of vaccines, including the use of mic

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21

Hiraragi, Hajime. "Study of lentiviral vector for in utero gene transfer and functional analysis of human T-lymphotropic virus type p13(II)." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1116532636.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 230 p.; also includes graphics. Includes bibliographical references (p. 200-230). Available online via OhioLINK's ETD Center

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22

Tomazatos, Alexandru [Verfasser]. "Arthropod-borne Viruses in Danube Delta: Surveillance, Phylogeography and Vector Feeding Patterns : Von Arthropoden übertragene Viren im Donaudelta: Überwachung, Phylogeographie und Vektorfütterung / Alexandru Tomazatos." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1221084097/34.

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23

Wong, Kiing Aik. "Age related seroepidemiological survey of measles, mumps, rubella, varicella zoster, herpes simplex type 1 and 2 viruses." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/age-related-seroepidemiological-survey-of-measles-mumps-rubella-varicella-zoster-herpes-simplex-type-1-and-2-viruses(7188f535-e90e-4e18-a5cb-9b5ed1a75c68).html.

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Age stratified seroepidemiological studies play a crucial role in the design and assessment of vaccination strategies. An existing multiplex bead immunoassay for measles, mumps, rubella and varicella zoster virus antibodies together with a newly developed multiplex bead immunoassay for herpes simplex virus type 1 and type 2 antibodies were used to investigate the age-related seroepidemiology of these viruses in England during 2012.To develop the HSV-1 and HSV-2 antibody assay, attempts were made to produce full length of HSV-1 and HSV-2 glycoprotein G using a baculovirus vector expression syst

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24

Boyd, Ann Marie. "Interactions between common vertebrate hosts and the mosquito vectors of Ross River and Barmah Forest viruses in urban Brisbane, South East Queensland, Australia /." [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe18059.pdf.

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25

Mulot, Michaël. "Analyse fonctionnelle du récepteur de l'éphrine de Myzus persicae et mise en évidence de son rôle dans la transmissino du virus de la jaunisse du navet." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAJ004/document.

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Les polérovirus infectent une large gamme de plantes d’intérêt économique. Ils sont transmis par un insecte vecteur, le puceron, selon le mode circulant non-multipliant. Le virus, acquis par le puceron lors de l’ingestion de sève sur une plante infectée, traverse l’épithélium des cellules intestinales puis celui des glandes salivaires par un mécanisme de transcytose impliquant des récepteurs encore inconnus. Le récepteur de l’éphrine (Eph) est une protéine membranaire dont un domaine est capable de se lier dans la levure aux protéines structurales des polérovirus. En développant des techniques

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26

Haugen, Samuel Arthur McGrath. "Assessing Cereal Aphid Diversity and Barley Yellow Dwarf Risk In Hard Red Spring Wheat and Durum." Thesis, North Dakota State University, 2018. https://hdl.handle.net/10365/28791.

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Barley yellow dwarf (BYD), caused by Barley yellow dwarf virus and Cereal yellow dwarf virus, and is a yield limiting disease of small grains. A research study was initiated in 2015 to identify the implications of BYD on small grain crops of North Dakota. A survey of 187 small grain fields was conducted in 2015 and 2016 to assess cereal aphid diversity; cereal aphids identified included, Rhopalosiphum padi, Schizaphis graminum, and Sitobion avenae. A second survey observed and documented field absence or occurrence of cereal aphids and their incidence. Results indicated prevalence and incidenc

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27

Pizzato, Massimo. "Retroviral vectors for gene therapy : characterisation of vector particle-cell interaction and development of novel packaging cell lines." Thesis, Institute of Cancer Research (University Of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313365.

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28

Vila, Julià Ferran. "Avenços en la teràpia gènica per al MNGIE amb vectors adenoassociats: validació en un model millorat de la malaltia i optimització de seqüència del gen terapèutic." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/671813.

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El MNGIE és una malaltia mitocondrial d’herència autosòmica recessiva causada per mutacions en el gen TYMP, que codifica l’enzim timidina fosforilasa (TP). La TP catalitza la degradació de timidina (dThd) i desoxiuridina (dUrd), i la seva absència en pacients causa l’acumulació sistèmica d’aquests metabòlits, tòxica per la funció mitocondrial. A dia d’avui les úniques teràpies efectives són el transplantament de cèl·lules mare hematopoètiques i el transplantament de fetge. No obstant, els transplantaments estan limitats per la necessitat d’un donant compatible i tenen una taxa de mortalitat i

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29

Minall, Leanne. "Synthetic glyco-viruses for targeted DNA vaccination vectors." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:9a7d2e5a-9053-40c6-969c-40dd39f2d02a.

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Viruses are powerful vectors for the delivery of nucleic acids, with applications in gene therapy and vaccination. However, major challenges for this technology include mis-targeting of the vector and neutralization by host antibody responses. Here we show that chemical addition of synthetic glycans to adenovirus (Ad) increased resistance to neutralizing antibodies and other critical host clearance mechanisms. Carbohydrate ligands were synthesised and functionalised with a cyanol methyl thiol group, which was subsequently activated to the amine reactive 2-imino- 2-methoxyethyl (IME). Ads were

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30

Mills, Mary Katherine. "Vector-pathogen interactions within the vector, Culicoides sonorensis." Diss., Kansas State University, 2017. http://hdl.handle.net/2097/38154.

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Doctor of Philosophy<br>Division of Biology<br>Kristin Michel<br>The biting midge, Culicoides sonorensis, vectors orbiviruses of economic importance, such as epizootic hemorrhagic disease virus (EHDV). Due to the limitations in available molecular tools, critical Culicoides-orbivirus interactions underlying vector competence remain unclear. To provide a foundation for the study of midge-EHDV interactions, RNA interference (RNAi) was developed as a reverse genetic tool, and EHDV-2 infection dynamics were determined within C. sonorensis. To develop RNAi, exogenous double-stranded RNA (dsRNA) was

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31

Dicks, Matthew Douglas James. "Novel adenovirus vaccine vectors." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:383aaf3d-284a-4bd7-877c-3270bd7c2e4f.

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Replication defective adenoviruses have emerged as promising vectors for delivery of vaccine antigens. The development of new vaccine vectors has recently focused on serotypes t, which the human population is less exposed in order to circumvent pre-existing anti vector immunity. This thesis describes the construction and optimisation of ChAdOX1, a new vector based on chimpanzee adenovirus Y2S, which has recently been manufactured to clinical grade for a Phase 1 human trial. Comparative immunogenicity studies between vectors of different serotype were performed in mice, with careful considerati

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32

Ma, Yuanmei. "Vesicular Stomatitis Virus as a Vector to Deliver Virus-Like Particles of Human Norovirus| A New Live Vectored Vaccine for Human Norovirus." Thesis, The Ohio State University, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=3710293.

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<p> Human norovirus (NoV) is the leading cause of acute non-bacterial gastroenteritis worldwide. Despite the significant health, emotional, and economic burden caused by human NoV, there are no vaccines or therapeutic interventions for this virus. This is due in major part to the lack of a cell culture system and an animal model for human NoV infection.</p><p> Thus, a vector-based vaccine may be ideal for controlling this disease. The major capsid gene (VP1) of a human NoV was inserted into the VSV genome at the glycoprotein (G) and large (L) polymerase gene junction. Recombinant VSV express

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33

Ma, Yuanmei. "Vesicular Stomatitis Virus as a Vector to Deliver Virus-Like Particles of Human Norovirus: A New Live Vectored Vaccine for Human Norovirus." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1357303520.

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34

Nanfack, Minkeu Ferdinand. "Interaction of novel natural RNA viruses with Anopheles malaria vectors." Electronic Thesis or Diss., Sorbonne université, 2018. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2018SORUS442.pdf.

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Les moustiques sont colonisés par un virome très peu étudié. Comme les bactéries, le virome influence probablement la biologie et l'immunité des populations de moustiques vecteurs, mais les modèles expérimentaux sont rares. Nous avons récemment découvert deux nouveaux virus chez le virome des vecteurs sauvages du paludisme, anophèles et des colonies d’Anopheles coluzzii : Anopheles C virus (AnCV) et Anopheles cypovirus (AnCPV). L’un ou les deux virus sont présents dans toutes les colonies de laboratoire d’An. gambiae et An. coluzzii. La prévalence des virus varie en fonction des stades du mous

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35

Liu, Zun Kearney Christopher Michel. "New viral vectors for the expression of antigens and antibodies in plants." Waco, Tex. : Baylor University, 2009. http://hdl.handle.net/2104/5341.

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36

Landazuri, Natalia. "Enhanced gene transfer using polymer-complexed retrovirus vectors." Thesis, Georgia Institute of Technology, 2001. http://hdl.handle.net/1853/20677.

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37

Cataldi, Marcela Patricia. "Diverse Effects of DNA Repair Pathways on the Outcome of Recombinant Adeno-Associated Virus (rAAV) Vector Gene Delivery." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1303842573.

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38

Melendez, Matias. "Site-specific Excision-Dependent (SED) vectors : a novel concept in herpes simplex virus type-1-based gene transfer vectors." Thesis, Lyon 1, 2011. http://www.theses.fr/2011LYO10269.

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L'objectif de mon sujet de thèse était de développer un nouveau type de vecteur viral pour le transfert de gènes, et de faire la preuve de concept de l'efficacité de ce vecteur en culture de cellules et chez la souris. L'idée centrale est de se servir de la très grande capacité transgénique du virus de l'herpès simplex de type 1 (HSV-1) pour transformer le génome de ce virus en une sorte de plateforme, ou rampe de lancement, qui permettra la production in vivo d'un vecteur herpétique secondaire de type amplicon, qui portera le transgène thérapeutique à d'autres cellules, augmentant ainsi signi

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Everett, Anthany Laurence. "Virus vector gene inserts are stabilized in the presence of satellite panicum mosaic virus coat protein." [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-3043.

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Voronin, Yegor A. "Investigation of initiation of reverse transcription in retroviruses using vectors with two primer-binding sites." Morgantown, W. Va. : [West Virginia University Libraries], 2003. http://etd.wvu.edu/templates/showETD.cfm?recnum=3136.

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Gaafar, Yahya Zakaria Abdou [Verfasser]. "Plant virus identification and virus-vector-host interactions / Yahya Zakaria Abdou Gaafar." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1220909262/34.

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42

Russell, Rebecca Alice. "Prototype foamy virus gene expression and hybrid vector development." Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.408262.

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Draper, Simon J. "Development of virus vector-based blood-stage Malaria Vaccines." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.509922.

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McAleer, Barry E. "Expression of mumps virus proteins in eukaryote vector systems." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.263462.

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45

Sweeney, Nathan Paul. "Foamy virus vector integration and application in gene therapy." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/50704.

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Foamy viruses (FVs) are unique ancient retroviruses that infect all non-human primates, but do not cause disease. We aimed to understand the FV pre-integration complex by isolating it from infected cells and characterising its protein constituents. Using a PCR to quantify integration in infected cells, we determined that integration occurs from 10 hours post-transduction. In synchronised cells, the peak of integration correlated well with cells passing through mitosis. However, we were unable to detect in vitro strand-transfer activity to indicate that active pre-integration complexes had been

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Viaplana, Rita. "Improving cauliflower mosaic virus gene vectors." Thesis, University of East Anglia, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365057.

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Twiddy, Sally Susanna. "The molecular epidemiology and evolution of dengue virus." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269490.

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48

Bergeron, Corinne. "Composition génétique de semences vaccinales H3N2 et construction d'un virus vecteur : une histoire d'encapsidation de segments chez les virus influenza de type A." Phd thesis, Université Claude Bernard - Lyon I, 2009. http://tel.archives-ouvertes.fr/tel-00625467.

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L'empaquetage des huit segments du génome des virus influenza de type A est une des étapes clef du cycle viral. Il intervient également dans l'apparition de virus réassortants, les virus pandémiques par exemple, ce qui en fait un enjeu fondamental de la recherche actuelle.Nous avons étudié ce mécanisme au cours de deux études, la première portant sur les vaccins antigrippaux (réassortiment), la seconde visant à construire un virus vecteur (incorporation d'un segment hétérologue). Les semences vaccinales sont obtenues par co-infection d'oeufs de poule embryonnés avec deux souches virales une do

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Majer, Eszter. "Metabolic engineering of plants using a disarmed potyvirus vector." Doctoral thesis, Universitat Politècnica de València, 2016. http://hdl.handle.net/10251/68477.

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[EN] Plant viruses are obligate intracellular parasites which were used to develop recombinant plant virus vectors to express heterologous proteins and to modify endogenous metabolic pathways of natural products in plants. The main limitation of many plant virus-based systems is the difficulty to co-express various heterologous proteins in the same cell with proper subcellular localization, which is a crucial question in metabolic engineering. This work provides a solution to overcome this problem by using a potyvirus-based vector system. Potyviruses (genus Potyvirus, family Potyviridae) are p

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Hu, Nai-Chung. "The development of penguinpox virus (PEPV) as a vaccine vector : transfer vector construction and rescue of virus growth in rabbit kidney cells (RK-13) by vaccinia virus K1." Master's thesis, University of Cape Town, 2010. http://hdl.handle.net/11427/10687.

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Includes bibliographical references (leaves 131-137).<br>Of the many vaccine trials which have taken place, the most promising results have been obtained from the recent phase 3 clinical trial which tested the ability of a dual protein and Canarypox virus recombinant to protect humans against HIV-1 infections. Because poxviruses are being developed as vaccine vectors against a number of diseases, it is important to continue the search for novel poxvirus vectors, in particular, those that do not cross-neutralize one another. This thesis describes the preliminary work performed on the developmen

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