Academic literature on the topic 'Vecteur cationique'
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Journal articles on the topic "Vecteur cationique":
Kichler, Antoine, Burkhard Bechinger, and Olivier Danos. "Des peptides cationiques antibactériens comme vecteurs de transfert de gènes." médecine/sciences 19, no. 11 (November 2003): 1046–47. http://dx.doi.org/10.1051/medsci/200319111046.
Denizot, M., U. Pereira, P. Delepine, C. Ferec, P. Lehn, L. Misery, and T. Montier. "P192 - Les lipophosphoramides cationiques : des vecteurs synthétiques de transfert de gènes efficaces pour la transfection de lignées cellulaires mélanocytaires." Annales de Dermatologie et de Vénéréologie 132 (October 2005): 188–89. http://dx.doi.org/10.1016/s0151-9638(05)79921-x.
Dissertations / Theses on the topic "Vecteur cationique":
Remy, Jean-Serge. "Synthese et utilisation in vitro de nouveaux vecteurs de transfert de genes." Strasbourg 1, 1994. http://www.theses.fr/1994STR15039.
Grosse, Stéphanie. "Trafic intracellulaire de complexes plasmide/ polymères cationiques glycosylés dans des cellules épithéliales des voies aériennes humaines : application à la thérapie génique de la mucoviscidose." Paris 7, 2004. http://www.theses.fr/2004PA077087.
Garcia, Chaumont Christine. "Etude in vitro de la vectorisation d'acides nucleiques par ama, un derive cationique de l'amphotericine b. (doctorat : pharmacotechnie et biopharmacie)." Paris 11, 1999. http://www.theses.fr/1999PA114840.
Colin, Morvane. "Transfert de gene par un vecteur non viral compose d'une sequence de ciblage des integrines et d'un liposome cationique : efficacite et devenir intracellulaire." Paris 6, 2000. http://www.theses.fr/2000PA066114.
Nouveau, Thibaut. "Nébulisation de nouveaux polyplexes pour le transfert de gènes." Electronic Thesis or Diss., Sorbonne université, 2023. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2023SORUS734.pdf.
Gene therapy is a form of therapy used to treat hereditary or acquired genetic diseases such as cancer or cystic fibrosis. Introducing a polynucleotide into diseased cells, either via the systmeic route or the local route (oral or nasal inhalation), corrects the defects causing the genetic mutations. However, DNA can only be internalized using a vector that protects it and enables it to reach the cell nucleus, where it will be transcribed. Various vectors (viral or synthetic) have been developed, such as PEI-based cationic polymer vectors. However, although effective, these PEI-based vectors are immunogenic at high doses. Functionalizations to reduce this toxicity, such as PEGylation, have been developed, making it possible to reinforce vectors by adding stealthiness to the final polyplexes. However, these strategies have their limitations, necessitating the synthesis of new types of polymer. POxylation represents a good alternative to PEG usage to form new polyplexes by adding a block formed from one or more poly(2-alkyl-2-oxazoline)s. The copolymers are synthesized by selective hydrolysis of a PEtOx-b-PnPrOx-b-PMeOx triblock copolymer using the thermosensitive properties of the hydrophobic blocks and a kosmotropic salt to form core-shell systems enabling hydrolysis of the PMeOx block to PEI. Then, the systems were formulated using a standard formulation and a "micro-extrusion" method. The polyplexes obtained were used in vitro experiments, by deposition or by a nebulization method, ideal for the treatment of pulmonary diseases. Very good transfection results were obtained, depending on various parameters (Mn, PEI, polymer architecture, +/- charge ratio)
Vaysse, Laurence. "Développement de vecteurs non viraux pour le transfert de gène dans l'épithélium respiratoire." Bordeaux 2, 2000. http://www.theses.fr/2000BOR28795.
Masson, Christophe. "Transfert de gênes cible vers les tumeurs : conception, synthèse et propriétés de nouveaux vecteurs chimiques de l'ADN pour le ciblage des cellules cancéreuses." Paris 6, 2001. http://www.theses.fr/2001PA066166.
Messai, Isabelle. "Élaboration de particules cationiques biodégradables comme vecteurs d'acides nucléiques." Lyon 1, 2004. http://www.theses.fr/2004LYO10162.
Durand-Dal-Maso, Angélique. "Synthèse et évaluation de vecteurs cationiques pour le transport des gènes thérapeutiques." Toulouse 3, 2006. http://www.theses.fr/2006TOU30079.
Development of gene therapy is essentially based on gene transfer systems development. Considering the problems associated with viruses as delivery systems, synthetic vectors were proved to be promising alternative to viral-based systems. Our research project lies within the scope of a program developed within company CAYLA aiming at developing new synthetic vectors for gene transfer. In this work, we designed three synthetic cationic lipid families, phosphonoammonium, phosphonopyridium and phonosphono or amidopolyamine. Thus we synthesized compounds with phytanyl lipidic chains, that are until now little used, as gene transfer vectors. Moreover, a method for the synthesis of long dissymmetric chains of phosphite and phosphonate was developed. Finally, the in vitro transfection activity of these compounds was assessed on different cell lines. Promising results were obtained since some cationic lipids exhibited transfection properties comparable or even better than those commercially available and that are commonly used as references
Tranchant, Isabelle. "Conception et synthèse de vecteurs non cationiques pour le transfert de gènes." Paris 6, 2002. http://www.theses.fr/2002PA066356.