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Journal articles on the topic 'VDA 6.3'

Author: Grafiati

Published: 28 June 2021

Last updated: 3 February 2022

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1

Shin, Yong Sam, Byung Moon Kim, Se-Hyuk Kim, et al. "Endovascular Treatment of Bilateral Intracranial Vertebral Artery Dissecting Aneurysms Presenting With Subarachnoid Hemorrhage." Operative Neurosurgery 70, suppl_1 (2011): ons75—ons81. http://dx.doi.org/10.1227/neu.0b013e31822ed1f0.

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Abstract BACKGROUND: Optimal management of bilateral vertebral artery dissecting aneurysms (bi-VDAs) causing subarachnoid hemorrhage (SAH) remains unclear. OBJECTIVE: To investigate the treatment methods and outcomes of bi-VDA causing SAH. METHODS: Seven patients were treated endovascularly for bi-VDA causing SAH. Treatment methods and outcomes were evaluated retrospectively. RESULTS: Two patients were treated with 2 overlapping stents for both ruptured and unruptured VDAs, 2 with 2 overlapping stents and coiling for ruptured VDA and with conservative treatment for unruptured VDA, 1 with inter

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Prisk, G. K., A. R. Elliott, H. J. Guy, J. M. Kosonen, and J. B. West. "Pulmonary gas exchange and its determinants during sustained microgravity on Spacelabs SLS-1 and SLS-2." Journal of Applied Physiology 79, no. 4 (1995): 1290–98. http://dx.doi.org/10.1152/jappl.1995.79.4.1290.

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We measured resting pulmonary gas exchange in eight subjects exposed to 9 or 14 days of microgravity (microG) during two Spacelab flights. Compared with preflight standing measurements, microG resulted in a significant reduction in tidal volume (15%) but an increase in respiratory frequency (9%). The increased frequency was caused chiefly by a reduction in expiratory time (10%), with a smaller decrease in inspiratory time (4%). Anatomic dead space (VDa) in microG was between preflight standing and supine values, consistent with the known changes in functional residual capacity. Physiological d

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3

Sekhon, H. S., and W. M. Thurlbeck. "Lung cytokinetics after exposure to hypobaria and/or hypoxia and undernutrition in growing rats." Journal of Applied Physiology 79, no. 4 (1995): 1299–309. http://dx.doi.org/10.1152/jappl.1995.79.4.1299.

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We measured resting pulmonary gas exchange in eight subjects exposed to 9 or 14 days of microgravity (microG) during two Spacelab flights. Compared with preflight standing measurements, microG resulted in a significant reduction in tidal volume (15%) but an increase in respiratory frequency (9%). The increased frequency was caused chiefly by a reduction in expiratory time (10%), with a smaller decrease in inspiratory time (4%). Anatomic dead space (VDa) in microG was between preflight standing and supine values, consistent with the known changes in functional residual capacity. Physiological d

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4

Hutson, Thomas E., Long H. Dang, Richard C. Lauer, et al. "Phase I/II study of a BNC105P/everolimus regimen for progressive metastatic renal cell carcinoma (mRCC) following prior tyrosine kinase inhibitors (Hoosier Oncology Group)." Journal of Clinical Oncology 30, no. 5_suppl (2012): 373. http://dx.doi.org/10.1200/jco.2012.30.5_suppl.373.

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373 Background: BNC105P is a Vascular Disruption Agent (VDA) that destabilizes tubulin polymers leading to selective damage of tumor vasculature, hypoxia and associated tumor necrosis. BNC105P also has a direct anti-proliferative action on cancer cells. Up regulation of the mTOR pathway has been identified as a survival response by the tumor to hypoxic insult. Preclinical investigations demonstrated that BNC105P is effective at selectively damaging the vasculature in primary and metastatic lesions. Furthermore, BNC105P monotherapy compared well with sunitinib in mice bearing kidney tumors. It

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Chebil, M., J. Soria, L. Chami, et al. "Interest of DCE-US with quantification to demonstrate the VDA effect on vascularization in patients with advanced solid tumors treated with AVE8062." Journal of Clinical Oncology 27, no. 15_suppl (2009): e14522-e14522. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e14522.

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e14522 Background: To determine the optimal time for the assessment of the perfusion in patients receiving AVE8062 (Vascular Disrupting Agent) at different doses combined with a fixed dose of cisplatin and then to correlate these results with the tumor response. Methods: Patients (pts) with advanced solid tumors, treated with AVE8062 (from 11.5 to 30 mg/m2) in combination with 75 mg/m2 cisplatin given every 3 weeks, were prospectively followed by DCE-US. DCE-US was performed before treatment, at 3 time points (0, 6 and 24 hours (h)) on Day 1 of the first (C1) and second cycle (C2), then every

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6

Desai, J., S. Wong, G. Chong, et al. "Phase I, pharmacokinetic, and pharmacodynamic evaluation of BNC105P, a novel anticancer agent that is both a vascular disrupting agent (VDA) and an inhibitor of cancer cell proliferation." Journal of Clinical Oncology 27, no. 15_suppl (2009): e14512-e14512. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.e14512.

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e14512 Background: BNC105P is a novel anticancer agent that inhibits tubulin polymerization and acts as a VDA. BNC105P is a phosphorylated parent compound which rapidly becomes the active agent BNC105. BNC105 exhibits 100-fold specificity for activated endothelial cells compared to quiescent endothelial cells. Methods: BNC105P (2.1 to 18.9 mg/m2) was given IV over 10 min on day 1 and 8 every 21 days to patients (pts) with advanced solid tumors (ECOG 0–2) and adequate organ function. The objectives were to determine safety, tolerability, MTD and pharmacokinetics (PK). A pharmacodynamic response

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Ricart, A. D., M. Cooney, J. Sarantopoulos, et al. "A phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of MN-029, a novel vascular disrupting agent (VDA), in patients (pts) with advanced solid tumors." Journal of Clinical Oncology 24, no. 18_suppl (2006): 3096. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.3096.

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3096 Background: MN-029 is a novel VDA that binds reversibly to the colchicine-binding site on tubulin and inhibits microtubule assembly, resulting in disruption of the cytoskeleton of tumor endothelial cells (EC). Disruption of the tumor EC cytoskeleton ultimately leads to a temporary reduction in tumor blood flow. Methods: MN-029 is administered IV as a 10–20 min infusion, at 3-wk intervals in pts with advanced cancer. The study has followed an accelerated titration design, with intrapatient dose escalation. PD effects on tumor blood flow are evaluated using dynamic contrast-enhanced magneti

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8

Lam, T. C., N. G. Shrive, and C. B. Frank. "Variations in Rupture Site and Surface Strains at Failure in the Maturing Rabbit Medial Collateral Ligament." Journal of Biomechanical Engineering 117, no. 4 (1995): 455–61. http://dx.doi.org/10.1115/1.2794207.

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The relationship between the pattern of surface strain and the site of failure in maturing rabbit ligaments was studied in vitro. Bone-medial collateral ligament (MCL)-bone complexes of 24 female New Zealand White rabbits at 3, 6, 9 and 12 months of age (n = 6 rabbits, 12 MCLs per group) were tested in tension to failure. A video dimension analysis (VDA) system was used to map the surface strain at failure across the width and along the length of the medial side of each MCL during testing. Results showed that the highest strains were consistently located at the femoral insertion decreasing tow

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9

Rischin, Danny, Daniela Matei, Jeffrey C. Goh, et al. "A phase I/II study of the vascular disrupting agent BNC105P in combination with gemcitabine-carboplatin in partially platinum-sensitive ovarian cancer patients in first or second relapse: An international collaborative group trial of ANZGOG and HOG." Journal of Clinical Oncology 31, no. 15_suppl (2013): TPS5612. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.tps5612.

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TPS5612 Background: BNC105P is a tubulin polymerization inhibitor and a vascular disrupting agent (VDA). In vivo exposure to BNC105P leads to selective damage of tumor vasculature in both primary and metastatic lesions, causing disruption of blood flow to tumors, hypoxia, and associated tumor necrosis. BNC105P also has a direct anti-proliferative action on cancer cells, including ovarian cancer cell lines. Pre-clinical data has demonstrated synergistic activity of BNC105P when combined with platinum or with gemcitabine, supporting the proposed study design. This study will determine the safety

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Libutti, Steven K., Lowell Brian Anthony, David J. Chaplin, and Julie Ann Sosa. "A phase II study of combretastatin A4-phosphate (CA4P) in the treatment of well-differentiated, low- to intermediate-grade, unresectable, recurrent, or metastatic pancreatic, or GI neuroendocrine tumors/carcinoid (GI-NETs/PNETs) with elevated biomarkers." Journal of Clinical Oncology 35, no. 4_suppl (2017): 432. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.432.

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432 Background: GI-NETs/PNETs are highly vascular tumors. CA4P, a vascular disrupting agent (VDA), occludes tumor vasculature resulting in ischemic necrosis. Pre-clinical studies of CA4P have shown activity in GI-NETs/PNETs. Methods: OX4218s is a phase II, single-arm, open-label study (NCT02132468) of CA4P in patients (pts) with GI-NETs/PNETs with elevated biomarkers who relapsed during or after standard-of-care treatment. Pts received CA4P 60 mg/m2 IV on days 1, 8, and 15 of a 21-day cycle for 3 cycles. Primary endpoint was change in biomarkers from baseline. Secondary endpoints were safety,

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Surman, Sherri L., Rhiannon R. Penkert, Robert E. Sealy, et al. "Consequences of Vitamin A Deficiency: Immunoglobulin Dysregulation, Squamous Cell Metaplasia, Infectious Disease, and Death." International Journal of Molecular Sciences 21, no. 15 (2020): 5570. http://dx.doi.org/10.3390/ijms21155570.

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Vitamin A is an important regulator of immune protection, but it is often overlooked in studies of infectious disease. Vitamin A binds an array of nuclear receptors (e.g., retinoic acid receptor, peroxisome proliferator-activated receptor, retinoid X receptor) and influences the barrier and immune cells responsible for pathogen control. Children and adults in developed and developing countries are often vitamin A-deficient or insufficient, characteristics associated with poor health outcomes. To gain a better understanding of the protective mechanisms influenced by vitamin A, we examined immun

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Chauhan, Dharminder, Ajita V. Singh, Madhavi Bandi, et al. "NPI-2358, a Novel Vascular Disrupting Agent Blocks Growth and Angiogenesis in Multiple Myeloma Cells." Blood 114, no. 22 (2009): 3842. http://dx.doi.org/10.1182/blood.v114.22.3842.3842.

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Abstract Abstract 3842 Poster Board III-778 Background and Rationale Vascular disrupting agents (VDAs) act via selectively disrupting established tumor vasculature and have shown remarkable clinical success as anti-cancer therapies. NPI-2358 is a novel VDA with a distinct structure and mechanism of action from other available VDAs. NPI-2358 binds to the colchicine-binding site of beta-tubulin preventing polymerization and disrupting the cytoplasmic microtubule network, thereby causing loss of vascular endothelial cytoskeletal function, and inducing cytotoxicity in cancer cells. Here, we examin

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Read, W. L., P. Rosen, P. Lee, et al. "Pharmacokinetic and pharmacodynamic results of a 4-hr IV administration phase I study with EPC2407, a novel vascular disrupting agent." Journal of Clinical Oncology 27, no. 15_suppl (2009): 3569. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.3569.

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3569 Background: EPC2407 is a 4-aryl-chromene single isomer microtubulin inhibitor with vascular disrupting and apoptotic activity at nanomolar concentrations. In an earlier phase I study dosing by 1 hr infusions daily x3 on a 21 day cycle, DLT at 21 mg/m2 was pain at tumor sites and vasoconstriction with increases of BP and QTc. MTD was 13 mg/m2 over 1 hr (ASCO 2008, Abst 2531). All drug-related toxicities resolved within an hour of stopping the infusion. Prolonged infusion of EPC2407 to extend exposure of tumor vasculature was designed with administration of EPC2407 over 4 hrs for 3 consecut

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Yoshihiro, Michishita, Makoto Hirokawa, Naohito Fujishima та ін. "CDR3-Independent Expansion of Vδ1 γδ T Lymphocytes and Depletion of Vδ2 T Cells Are Unique Features in Acquired Chronic Pure Red Cell Aplasia",. Blood 118, № 21 (2011): 3429. http://dx.doi.org/10.1182/blood.v118.21.3429.3429.

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Abstract Abstract 3429 Background: Idiopathic PRCA and secondary PRCA associated with thymoma and large granular lymphocyte leukemia are major subtypes of adult-onset chronic PRCA. We have previously shown that these types of PRCA are responsive to immunosuppressive therapy but most patients require long-term maintenance immunosuppressive treatment. These results suggest that acquired chronic PRCA is an autoimmune disorder mediated by T lymphocytes and pathogenic T cell clones may be persistently present during remission. We have previously made an interesting observation that a thymoma-associ

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15

Li, Z., and Z. Jiao. "P61 Population pharmacokinetics of vancomycin in chinese ICU neonates: initial dosage recommendations." Archives of Disease in Childhood 104, no. 6 (2019): e42.2-e42. http://dx.doi.org/10.1136/archdischild-2019-esdppp.99.

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The main goal of our study was to characterize the population pharmacokinetics of vancomycin in critically ill Chinese neonates to develop a pharmacokinetic model and investigate factors that have significant influences on the pharmacokinetics of vancomycin in this population.1 2 The study population consisted of 80neonates in the neonatal intensive care unit (ICU)from which 165 trough and peak concentrations of vancomycin were obtained.Nonlinear mixed effect modeling was used to develop a population pharmacokinetic model for vancomycin.4 The stability and predictive ability of the final model

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16

Valiulis, Skirmundas Jonas. "Lietuvos fotožurnalistikos pradžia Europos kontekste." Žurnalistikos Tyrimai 1 (January 1, 2008): 143–53. http://dx.doi.org/10.15388/zt/jr.2008.1.89.

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Pirmasis fotožurnalistikos raidą Lietuvoje yra iš dalies apžvelgęs V. Juodakis knygoje „Lietuvos fotografijos istorija“ (iki 1940m.)1. Ši knyga skirta visos fotografijos istorijai, tad fotožurnalistika buvo analizuojama tik kaip vienas iš fotografijos plėtotės barų, glaustai ir eskiziškai, bet pasitelkus būtiniausius faktus, svarbiausius leidinius, aptarus fotožurnalistikos žanrus, parodžius kiekybišką augimą įvairiuose leidiniuose. V. Juodakis pirmasis plačiau įvedė XIX a. – XXa. pradžios Lietuvos fotografiją į tarptautinę erdvę Londone leidžiamame žurnale „Fotografijos istorija“2.Per atsikūr

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Astapova, Elena V., Max E. Stachura, Cynthia Chernecky, and Marlene M. Rosenkoetter. "Low-End Videoconferencing for Vascular Access Device Site Assessment in Homecare." Journal of the Association for Vascular Access 13, no. 3 (2008): 135–38. http://dx.doi.org/10.2309/java.13-3-6.

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Abstract Vascular access devices (VAD) represent high technology and are used frequently in infant, pediatric, adult, and geriatric populations for vascular infusion of chemotherapy, immunotherapy, blood products, biologic response modifiers, nutrition support, analgesics, ionotropics, antibiotics, and other medications, as well as for extraction of pleural fluid from patients with chronic effusions and for treatment with dialysis. Increasingly, these devices are migrating to the home setting as they are used in chronic care and as insurance requirements reduce access to prolonged hospital sta

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Ranzoni, Carlo. "THE RIGHT TO EXAMINE WITNESSES UNDER ARTICLE 6 §§ 1 AND 3 (D) OF THE EUROPEAN CONVENTION ON HUMAN RIGHTS." Visnyk of the Lviv University. Series Law, no. 67 (December 24, 2018): 85–93. http://dx.doi.org/10.30970/vla.2018.67.085.

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Setiadi, D., P. M. Sarro, and P. P. L. Regtien. "A 3 × 1 integrated pyroelectric sensor based on VDF/TrFE copolymer." Sensors and Actuators A: Physical 52, no. 1-3 (1996): 103–9. http://dx.doi.org/10.1016/0924-4247(96)80133-6.

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20

Marwaha, Ramank K., M. K. Garg, Sushil Gupta, et al. "Association of insulin-like growth factor-1 and IGF binding protein-3 with 25-hydroxy vitamin D in pre-pubertal and adolescent Indian girls." Journal of Pediatric Endocrinology and Metabolism 31, no. 3 (2018): 289–95. http://dx.doi.org/10.1515/jpem-2017-0275.

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AbstractBackground:There is a high prevalence of vitamin D deficiency (VDD) in India. Molecular mechanisms suggest a strong relationship between vitamin D and growth factors. However, there is a paucity of literature with regard to a relationship between insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and vitamin D particularly in subjects with VDD. The objective of the study was to assess the relationship between growth factors and serum vitamin D-parathormone (PTH) status in school girls and study the impact of vitamin D supplementation on growth

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Grand, Beatriz, Jorge Solimano, Adriana Ventura, Ernesto Quiroga Micheo, and Dardo Riveros. "Carotid and Vertebral Artery Dissection Syndromes." Blood 106, no. 11 (2005): 4145. http://dx.doi.org/10.1182/blood.v106.11.4145.4145.

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Abstract Objetives: To describe the clinical presentation, diagnosis and treatment of patients with carotid and vertebral artery dissection (CAD, VAD). Design: Retrospective, observational Patients and methods: Clinical recording were evaluated from 1996 to 2005; 6 patients (3 women, 3 men, mean age 37 years) with CAD (3) and VAD (3) were referred to our hematology unit. Clinical presentation: progressing stroke 4/6 and transient ischemic attack (TIA) 2/6; warning sings and symptoms preceding the onset of stroke in 80%. Vascular risk factors included smoking and hypertension; associated featur

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Shibahara, Tomoya, Masahiro Yasaka, Yoshiyuki Wakugawa, et al. "Improvement and Aggravation of Spontaneous Unruptured Vertebral Artery Dissection." Cerebrovascular Diseases Extra 7, no. 3 (2017): 153–64. http://dx.doi.org/10.1159/000481442.

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Background: Intracranial vertebral artery dissection (VAD) is a well-recognized cause of stroke in young and middle-aged individuals, especially in Asian populations. However, a long-term natural course remains unclear. We investigated the long-term time course of VAD using imaging findings to examine the rate and predisposing factors for improvement. Methods: We registered 56 consecutive patients (40 males; mean age, 51.8 ± 10.7 years) with acute spontaneous VAD and retrospectively investigated neuroimaging and clinical course within 1 month and at 3 months ± 2 weeks, 6 months ± 2 weeks, and

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Alaofè, Halimatou, Jennifer Burney, Rosamond Naylor, and Douglas Taren. "Prevalence of anaemia, deficiencies of iron and vitamin A and their determinants in rural women and young children: a cross-sectional study in Kalalé district of northern Benin." Public Health Nutrition 20, no. 7 (2017): 1203–13. http://dx.doi.org/10.1017/s1368980016003608.

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AbstractObjectiveTo identify the magnitude of anaemia and deficiencies of Fe (ID) and vitamin A (VAD) and their associated factors among rural women and children.DesignCross-sectional, comprising a household, health and nutrition survey and determination of Hb, biochemical (serum concentrations of ferritin, retinol, C-reactive protein and α1-acid glycoprotein) and anthropometric parameters. Multivariate logistic regression examined associations of various factors with anaemia and micronutrient deficiencies.SettingKalalé district, northern Benin.SubjectsMother–child pairs (n 767): non-pregnant

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Chuk, M. K., F. M. Balis, C. Mackall, et al. "Radiographic tumor response in pediatric patients with newly diagnosed localized (LOC) or metastatic (MET) Ewing’s sarcoma (EWS) following neoadjuvant chemotherapy." Journal of Clinical Oncology 25, no. 18_suppl (2007): 20008. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.20008.

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20008 Background: Standard treatment for EWS includes vincristine, doxorubicin, cyclophosphamide (VDC) alternating with ifosfamide and etoposide (IE). Using this therapy, overall survival is 70% in patients with LOC EWS and 30% in patients with MET EWS. We compared the radiographic response to VDC and IE in patients with LOC or MET EWS. Methods: We conducted a randomized trial comparing pegfilgrastim to filgrastim in patients treated with VDC (cycles 1, 2, 5, 9, 11, 13) and IE (cycles 3, 4, 6–8, 10, 12, 14). Local control with radiation or surgery was initiated after cycle 5. We assessed radio

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Meng, Deng-Hong, Ying Zhang, Shuang-Shuang Ma, et al. "The role of parathyroid hormone during pregnancy on the relationship between maternal vitamin D deficiency and fetal growth restriction: a prospective birth cohort study." British Journal of Nutrition 124, no. 4 (2020): 432–39. http://dx.doi.org/10.1017/s0007114520001105.

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AbstractPrevious studies have shown conflicting findings regarding the relationship between maternal vitamin D deficiency (VDD) and fetal growth restriction (FGR). We hypothesised that parathyroid hormone (PTH) may be an underlying factor relevant to this potential association. In a prospective birth cohort study, descriptive statistics were evaluated for the demographic characteristics of 3407 pregnancies in the second trimester from three antenatal clinics in Hefei, China. The association of the combined status of vitamin D and PTH with birth weight and the risk of small for gestational age

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Mologni, Luca, Isabella Ponzanelli, Filippo Bresciani, et al. "The Novel Synthetic Retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) Causes Apoptosis in Acute Promyelocytic Leukemia Cells Through Rapid Activation of Caspases." Blood 93, no. 3 (1999): 1045–61. http://dx.doi.org/10.1182/blood.v93.3.1045.

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Abstract The synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437), which was originally developed as an retinoic acid receptor (RAR)-γ agonist, induces rapid apoptosis in all-trans retinoic acid (ATRA)-sensitive and ATRA-resistant clones of the NB4 cell line, a widely used experimental model of acute promyelocytic leukemia (APL). In addition, the compound is apoptogenic in primary cultures of freshly isolated APL blasts obtained from a newly diagnosed case and an ATRA-resistant relapsed patient. NB4 cells in the S-phase of the cycle are most sensitive to CD4

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Mologni, Luca, Isabella Ponzanelli, Filippo Bresciani, et al. "The Novel Synthetic Retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid (CD437) Causes Apoptosis in Acute Promyelocytic Leukemia Cells Through Rapid Activation of Caspases." Blood 93, no. 3 (1999): 1045–61. http://dx.doi.org/10.1182/blood.v93.3.1045.403k22_1045_1061.

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The synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437), which was originally developed as an retinoic acid receptor (RAR)-γ agonist, induces rapid apoptosis in all-trans retinoic acid (ATRA)-sensitive and ATRA-resistant clones of the NB4 cell line, a widely used experimental model of acute promyelocytic leukemia (APL). In addition, the compound is apoptogenic in primary cultures of freshly isolated APL blasts obtained from a newly diagnosed case and an ATRA-resistant relapsed patient. NB4 cells in the S-phase of the cycle are most sensitive to CD437-trigge

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Jakubowiak, Andrzej, Tara Kendall, Ammar Al-Zoubi, et al. "Initial Treatment with Bortezomib (Velcade®), Doxil®, and Dexamethasone (VDD) Is Superior to Thalidomide and Dexamethasone (TD) as Initial Therapy Prior to Autologous Stem Cell Transplantation (ASCT) for Multiple Myeloma (MM)." Blood 112, no. 11 (2008): 3713. http://dx.doi.org/10.1182/blood.v112.11.3713.3713.

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Abstract A number of novel combinations used in initial therapy of myeloma show improved overall response (OS) and complete and near complete response (CR/nCR) rates. However, it is not clear if improved responses impact the results after the subsequent ASCT and the overall outcome of MM therapy. To address this issue, we performed a retrospective analysis of patients with symptomatic myeloma who were initially treated with TD (N= 31) or VDD (N =30) followed by ASCT, as part of 2 consecutive clinical studies conducted at the University of Michigan Cancer Center. From July 2003 to May 2005, 31

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Kim, Chul Soo, Moon Hee Lee, Inho Kim, et al. "Combination Chemotherapy Using Cyclophosphamide and High Dose Dexamethasone with or without Radiotherapy for the Treatment of Multiple Myeloma." Blood 106, no. 11 (2005): 5168. http://dx.doi.org/10.1182/blood.v106.11.5168.5168.

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Abstract Forty two people (men 22, women 20) diagnosed as Durie-Salmon stage IIIA or B multiple myeloma were treated with a combination chemotherapy consisting of cyclophosphamide at 400mg and dexamethasone at 40mg (CHD) regardless of body surface for 4 or 5 consecutive days every 3 or 4 weeks from August 1996 through July 2005. The treatment was repeated as long as the patient could tolerate or until disease progressed. The chemotherapy was given to 36 chemo-naïve patients as primary therapy and to 6 patients exposed to VAD (vincristine, doxorubicin, dexamethasone) as salvage therapy. Pallia

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Meerbach, A., A. Holý, P. Wutzler, E. De Clercq, and J. Neyts. "Inhibitory Effects of Novel Nucleoside and Nucleotide Analogues on Epstein—Barr Virus Replication." Antiviral Chemistry and Chemotherapy 9, no. 3 (1998): 275–82. http://dx.doi.org/10.1177/095632029800900309.

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The anti-Epstein–Barr virus (EBV) activity of different classes of compounds was assessed by means of an EBV DNA hybridization assay using a digoxigenin-labelled probe specific for the BamHI W fragment of the EBV genome, as well as by measuring viral capsid antigen (VCA) expression after a 7 day incubation period of P3HR-1 producer cells with the test substances. Acyclovir, ganciclovir, cidofovir and zidovudine were included as reference compounds. Several compounds proved to be potent and selective inhibitors of EBV DNA synthesis and VCA expression. Of the new compounds that were evaluated fo

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Laxmaiah, Avula, Madhavan K. Nair, Nimmathota Arlappa, et al. "Prevalence of ocular signs and subclinical vitamin A deficiency and its determinants among rural pre-school children in India." Public Health Nutrition 15, no. 4 (2011): 568–77. http://dx.doi.org/10.1017/s136898001100214x.

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AbstractObjectiveTo assess the magnitude and determinants of vitamin A deficiency (VAD) and coverage of vitamin A supplementation (VAS) among pre-school children.DesignA community-based cross-sectional study was carried out by adopting a multistage, stratified, random sampling procedure.SettingRural areas of eight states in India.SubjectsPre-school children and their mothers were covered.ResultsA total of 71 591 pre-school children were clinically examined for ocular signs of VAD. Serum retinol concentrations in dried blood spots were assessed in a sub-sample of 3954 children using HPLC. The p

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Oliveira, Cristieli SM, Patrícia Sampaio, Pascoal T. Muniz, and Marly A. Cardoso. "Multiple micronutrients in powder delivered through primary health care reduce iron and vitamin A deficiencies in young Amazonian children." Public Health Nutrition 19, no. 16 (2016): 3039–47. http://dx.doi.org/10.1017/s1368980016001294.

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AbstractObjectiveWe evaluated the effect of home fortification with multiple micronutrient powder (MNP) on anaemia and micronutrient status of young Amazonian children.DesignA pragmatic controlled trial was performed. A control group (CG) of children aged 11–14 months was recruited in the routine of primary health-care centres for assessing anaemia and micronutrient status. At the same time, an intervention group (IG) of infants aged 6–8 months was recruited in the same health centres to receive MNP daily in complementary feeding for 2 months. The IG children were assessed 4–6 months after enr

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Kanitakis, Jean, Palmina Petruzzo, Aram Gazarian, et al. "Premalignant and Malignant Skin Lesions in Two Recipients of Vascularized Composite Tissue Allografts (Face, Hands)." Case Reports in Transplantation 2015 (2015): 1–4. http://dx.doi.org/10.1155/2015/356459.

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Recipients of solid organ transplants (RSOT) have a highly increased risk for developing cutaneous premalignant and malignant lesions, favored by the lifelong immunosuppression. Vascularized composite tissue allografts (VCA) have been introduced recently, and relevant data are sparse. Two patients with skin cancers (one with basal cell carcinoma and one with squamous cell carcinomas) have been so far reported in this patient group. Since 2000 we have been following 9 recipients of VCA (3 face, 6 bilateral hands) for the development of rejection and complications of the immunosuppressive treatm

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Sandra, Ferry, Karina Febriani Hudono, Amelia Astriani Putri, and Chantika Amardhia Paramita Putri. "Caspase Inhibitor Diminishes Caffeic Acid-induced Apoptosis in Osteosarcoma Cells." Indonesian Biomedical Journal 9, no. 3 (2017): 160. http://dx.doi.org/10.18585/inabj.v9i3.334.

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BACKGROUND: Caffeic acid has been shown to induce apoptosis in MG63 osteosarcoma cells. Along with the apoptotic induction, caffeic acid was shown to activate caspase-8, -9 and -3. However, the role of caspase in mediating caffeic acid-induced apoptosis in MG63 cells are not clear yet. In this study, caspase role was further investigated by inhibiting caspase activity in the caffeic acid-induced apoptosis system in the MG63 cells.METHODS: MG63 cells were cultured, starved, pretreated with/without Z-VAD FMK and treated with/without 10 µg/mL caffeic acid. To quantify the number of apoptotic MG63

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Kumar, Shaji, Ian W. Flinn, Paul G. Richardson, et al. "Novel Three- and Four-Drug Combination Regimens of Bortezomib, Dexamethasone, Cyclophosphamide, and Lenalidomide, for Previously Untreated Multiple Myeloma: Results From the Multi-Center, Randomized, Phase 2 EVOLUTION Study." Blood 116, no. 21 (2010): 621. http://dx.doi.org/10.1182/blood.v116.21.621.621.

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Abstract Abstract 621 Background: Two- and three-drug regimens incorporating bortezomib (Velcade®, V), lenalidomide (Revlimid®, R), dexamethasone (D), or cyclophosphamide (C) have been shown to be effective and well tolerated in previously untreated multiple myeloma (MM). Combining all four drugs in a single regimen (VDCR) may further enhance efficacy. Published results from the phase 1 dose-escalation portion of the non-comparative, multi-center EVOLUTION study showed that the VDCR regimen was highly active and generally well tolerated (Kumar et al Leukemia 2010). Here we present updated resu

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Jakubowiak, Andrzej J., Lindsey Brackett, Tara Kendall, Judah Friedman, and Mark S. Kaminski. "Combination Therapy with Velcade, Doxil, and Dexamethasone (VDD) for Patients with Relapsed/Refractory Multiple Myeloma (MM)." Blood 106, no. 11 (2005): 5179. http://dx.doi.org/10.1182/blood.v106.11.5179.5179.

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Abstract Background: Combination regimens with Velcade demonstrate high activity in both relapsed/refractory and newly diagnosed MM, including higher than previously observed rates of complete responses (CR) and near complete responses (nCR). In this study, we evaluated the activity of a combination of Velcade, Doxil, and Dexamethasone (VDD) in relapsed/refractory MM. The rationale for combining these 3 agents was provided in pre-clinical studies which showed that Velcade can synergize with DNA-damaging agents via caspase-8 pathway and with Dexamethasone via caspase-9 pathway. In addition, pri

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Gramberg, U. "Dünnschichttechnologien. Verfahren, Trends. Chancen. Hrsg.:VDI-Technologiezentrum Physikalische Technologien. 82 S.; 43 Abb., 6 Tab., DIN A5. VDI-Verlag, Düsseldorf 1991. Br. DM 20,-. ISBN 3-18-401172-0." Materials and Corrosion 43, no. 7 (1992): 380. http://dx.doi.org/10.1002/maco.19920430715.

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Yoon, Sung-Soo, Hye Jin Kim, Dong Soon Lee, et al. "Sequential VAD (Vincristine, Adriamycin, Dexamethasone) and VTD (VELCADE®, Thalidomide, Dexamethasone) Induction Followed by High-Dose Therapy with Autologous Stem Cell Transplantation and Maintenance Treatment with VELCADE for Newly Diagnosed Multiple Myeloma: Interim Results of Phase II Trial." Blood 110, no. 11 (2007): 952. http://dx.doi.org/10.1182/blood.v110.11.952.952.

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Abstract Introduction Effective reduction of myeloma before autologous stem cell transplantation (ASCT) prolongs survival in multiple myeloma patients. Recently, incorporation of novel agents resulted in improved response rate and reduced side effect in newly diagnosed multiple myeloma. Method: Patients are planned to receive 2 cycles of VAD (vincristine 0.4mg D1-4, adriamycin 9mg/m2 D1-4, dexamethasone 40mg D1-4, 9–12 every 3 weeks), and VTD (bortezomib 1.3mg/m2 D1, 4, 8, 11, thalidomide 100mg daily, dexamethasone 40mg D1-4, 9–12 every 3 weeks). High dose melphalan (200mg/m2) is used as a con

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Urlić, Iris, Željko Verzak, and Dubravka Negovetić Vranić. "Measuring the Influence of Galilean Loupe System on Near Visual Acuity of Dentists under Simulated Clinical Conditions." Acta Stomatologica Croatica 50, no. 3 (2016): 235–41. http://dx.doi.org/10.15644/asc50/3/6.

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Ivanov, P. A., A. M. Fain, and M. V. Sychevsky. "LIFE JOURNEY: MEDICAL AND SCIENTIFIC WORK OF PROFESSOR V.A. SOKOLOV." Sklifosovsky Journal "Emergency Medical Care" 6, no. 3 (2017): 280–86. http://dx.doi.org/10.23934/2223-9022-2017-6-3-280-286.

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Warschburger, Petra. "Prävention kindlicher Adipositas: Was beeinflusst die Inanspruchnahme von Präventionsangeboten?" Public Health Forum 18, no. 4 (2010): 14–15. http://dx.doi.org/10.1016/j.phf.2010.09.006.

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EinleitungPräventionsangebote werden selten, besonders Risikogruppen, angenommen. Mütter 3- bis 6 jähriger Kinder wurden u.a. zu hinderlichen und förderlichen Faktoren für die Teilnahmebereitschaft befragt. Viele Mütter betrachten demnach Übergewicht nicht als relevantes Problem und unterschätzen die damit verbundenen körperlichen und psychischen Belastungen. Die Teilnahmebereitschaft war gering ausgeprägt; Hinderungsgründe wurden v.a. bezogen auf organisatorische Aspekte benannt.

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Roberts, Scott C., Jonathan D. Rich, Duc T. Pham, Rebecca Harap, and Valentina Stosor. "1177. A Spectrum of Infectious Complications in Continuous-Flow Ventricular Assist Devices: A Single-Center Longitudinal Cohort." Open Forum Infectious Diseases 6, Supplement_2 (2019): S421—S422. http://dx.doi.org/10.1093/ofid/ofz360.1040.

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Abstract Background Infections remain a frequent complication of patients (patients) with ventricular assist devices (VAD). We evaluated the epidemiology and outcomes of VAD infections at our center over a 10-year period. Methods We performed a retrospective cohort study of continuous-flow VAD recipients from July 2008-September 2018. VAD-specific and -related infections were characterized according to 2013 ISHLT definitions. Summary and comparative statistics were performed using IBM® SPSS Statistics version 25.0. Results 433 VADs were implanted into 375 patients. A total of 86 VAD infections

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Suh, Sang Hyun, Byung Moon Kim, Sung Il Park, et al. "Stent-assisted coil embolization followed by a stent-within-a-stent technique for ruptured dissecting aneurysms of the intracranial vertebrobasilar artery." Journal of Neurosurgery 111, no. 1 (2009): 48–52. http://dx.doi.org/10.3171/2009.2.jns081418.

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Object A ruptured dissecting aneurysm of the vertebrobasilar artery (VBA-DA) is a well-known cause of acute subarachnoid hemorrhage (SAH) with a high rate of early rebleeding. Internal trapping of the parent artery, including the dissected segment, is one of the most reliable techniques to prevent rebleeding. However, for a ruptured VBA-DA not suitable for internal trapping, the optimal treatment method has not been well established. The authors describe their experience in treating ruptured VBA-DAs not amenable to internal trapping of the parent artery with stent-assisted coil embolization (S

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Kumar, Shaji, Ian W. Flinn, Parameswaran N. Hari, et al. "Novel Three– and Four–Drug Combinations of Bortezomib, Dexamethasone, Cyclophosphamide, and Lenalidomide, for Newly Diagnosed Multiple Myeloma: Encouraging Results From the Multi-Center, Randomized, Phase 2 EVOLUTION Study." Blood 114, no. 22 (2009): 127. http://dx.doi.org/10.1182/blood.v114.22.127.127.

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Abstract Abstract 127 Two- and three-drug regimens incorporating bortezomib (Velcade®, Vc), lenalidomide (Revlimid®, Rev), dexamethasone (Dex), and cyclophosphamide (Cy) (Vc–Dex, Rev–Dex, Vc–Dex–Rev [VDR], and Vc–Dex–Cy [VDC]), have been shown to be effective and well tolerated in previously untreated multiple myeloma (MM). Combining Vc and Dex with Rev and Cy in a novel four-drug regimen (VDCR) may result in even greater activity with improved quality and duration of response. Results from the phase 1 dose-escalation portion of the multi-center EVOLUTION study showed that the VDCR regimen is

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Harousseau, Jean-Luc, Gerald Marit, Denis Caillot, et al. "VELCADE/Dexamethasone (Vel/Dex) Versus VAD as Induction Treatment Prior to Autologous Stem Cell Transplantation (ASCT) in Newly Diagnosed Multiple Myeloma (MM): An Interim Analysis of the IFM 2005-01 Randomized Multicenter Phase III Trial." Blood 108, no. 11 (2006): 56. http://dx.doi.org/10.1182/blood.v108.11.56.56.

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Abstract ASCT is considered the standard of care for patients up to 65 years of age with MM. The optimal induction treatment prior to ASCT is still unknown. VAD is a commonly used regimen but is associated with a number of toxicities, administrative inconvenience, and a complete remission (CR) rate of typically less than 10%. Recently the combination thalidomide/Dex was reported to induce a higher overall response rate than Dex alone in newly diagnosed patients, but with significantly more toxicities, especially deep vein thrombosis, and a 4% CR rate (Rajkumar et al, J Clin Oncol 2006;24:431–6

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Krupa, Tadeusz. "V.A. Gorbatov Theory of Characterization - Principles and Examples." Foundations of Management 5, no. 3 (2014): 89–102. http://dx.doi.org/10.2478/fman-2014-0022.

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AbstractCharacterization theory was developed in the 1970s by a member of the Russian Academy of Sciences, a prominent cybernetics V.A. Gorbatov, and became the nucleus of an international school. Many of today’s academy graduates make a new generation of scholars, more than 150 doctors and assistant professors, developing a new descriptive theory of cybernetic complex systems, based on the canon of the so-called characterization principle, binding the sets of y¥a functioning models and x¥bstructure models using the paradigm of monotone mappings of the considered system. This article presents

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Niraula, S., Y. S. Zong, L. Z. Zhai, C. C. Guo, and T. Y. Lin. "Investigation on the serum antibodies levels against Epstein-Barr virus in pulmonary lymphoepithelioma-like carcinoma." Journal of Clinical Oncology 25, no. 18_suppl (2007): 18186. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.18186.

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18186 Background: Pulmonary lymphoepithelioma-like carcinoma (PLELC) belongs to large cell sub-type of non-small cell lung cancer (NSCLC) with just about 160 cases reported previously. Its epidemiology, prognosis and therapeutic approach is evidently different from other NSCLCs. EBV infection is seen in 100% of Asian PLELC patients whenever tested. The aim of this study was to analyze serum antibodies level against EBV in PLELC patients. Methods: Sera of all seven patients with re-confirmed PLELC from a single institute in Canton, China in the past 4 years were collected. Serum levels of 8 dif

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Ludwig, Heinz, Werner Linkesch, Hedwig Kasparu, et al. "Prospective, Randomized Comparison between Double Transplantation (T) with Melphalan (200 mg/m2) and Triple T with Intermediate Dose Melphalan (100 mg/m2) in Patients with Multiple Myeloma (An Interim Analysis)." Blood 108, no. 11 (2006): 3083. http://dx.doi.org/10.1182/blood.v108.11.3083.3083.

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Abstract In this study we compare the efficacy and toxicity of double T with M 200 with triple T using M 100 in newly diagnosed pts with MM. 175 pts have as yet been enrolled and 135 have been randomized after VAD induction treatment and stem cell collection to either tandem or triple transplantation. Reasons for non-randomization were too early for T (n=22), PD after induction (n=5), early death (n=3), toxicity (n=3), pt. refusal (n=3), and others (n=4). Median age of the 135 pts randomized was 59 years (range: 27–70 years). Stage I: 8%, stage II: 17%, stage III: 75%, Paraprotein Isotypes: Ig

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Turner, M. R., and T. L. Pallone. "Vasopressin constricts outer medullary descending vasa recta isolated from rat kidneys." American Journal of Physiology-Renal Physiology 272, no. 1 (1997): F147—F151. http://dx.doi.org/10.1152/ajprenal.1997.272.1.f147.

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Arginine vasopressin (AVP) can selectively decrease blood flow in the renal medulla, but the sites of vasoconstriction are uncertain. We have examined the effects of vasopressin-receptor agonists and antagonists on the diameters of outer medullary descending vasa recta (OMDVR), isolated and perfused in vitro. AVP can constrict OMDVR, apparently via V1a-receptors. Ablumenal AVP (10(-10)-10(-6)M) or the selective V1a-receptor agonist [Phe2, Ile3, Orn8]-vasopressin (PO-VT, 10(-8) M) constricted OMDVR focally and (at higher AVP concentrations) transiently. The V1b agonist ideamino-Cys1,D-3-(pyridy

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Roussel, Murielle, Anne Huynh, Philippe Moreau, et al. "Bortezomib (BOR) and High Dose Melphalan (HDM) as Conditioning Regimen Before Autologous Stem Cell Transplantation (ASCT) for De Novo Multiple Myeloma (MM): Final Results of the IFM Phase II Study VEL/MEL." Blood 112, no. 11 (2008): 160. http://dx.doi.org/10.1182/blood.v112.11.160.160.

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Abstract Introduction: ASCT is recommended for young patients (pts) with newly diagnosed MM. The achievement of Complete Response (CR) or at least Very Good Partial Response (VGPR) is the main prognostic factor for survival after ASCT. However, only 40–50% of patients achieve CR and VGPR with current HDM regimen. BOR has demonstrated significant activity in relapsed/refractory pts, a synergistic effect with Melphalan (MEL) and a lack of prolonged hematological toxicity. The combination of BOR and HDM is therefore a logical approach to attempt to improve CR+VGPR rates after ASCT. Methods: In Ju

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