Relevant bibliographies by topics / Vascularized tissue

Academic literature on the topic 'Vascularized tissue'

Author: Grafiati
Published: 7 September 2022
Last updated: 18 September 2022

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Journal articles on the topic "Vascularized tissue"

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Jain, Rakesh K., Patrick Au, Josh Tam, Dan G. Duda, and Dai Fukumura. "Engineering vascularized tissue." Nature Biotechnology 23, no. 7 (July 2005): 821–23. http://dx.doi.org/10.1038/nbt0705-821.

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Neumeister, Michael W., Tammy Wu, and Christopher Chambers. "Vascularized Tissue-Engineered Ears." Plastic and Reconstructive Surgery 117, no. 1 (January 2006): 116–22. http://dx.doi.org/10.1097/01.prs.0000195071.01699.ce.

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Xing, Fei, Zhou Xiang, Pol Maria Rommens, and Ulrike Ritz. "3D Bioprinting for Vascularized Tissue-Engineered Bone Fabrication." Materials 13, no. 10 (May 15, 2020): 2278. http://dx.doi.org/10.3390/ma13102278.

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Vascularization in bone tissues is essential for the distribution of nutrients and oxygen, as well as the removal of waste products. Fabrication of tissue-engineered bone constructs with functional vascular networks has great potential for biomimicking nature bone tissue in vitro and enhancing bone regeneration in vivo. Over the past decades, many approaches have been applied to fabricate biomimetic vascularized tissue-engineered bone constructs. However, traditional tissue-engineered methods based on seeding cells into scaffolds are unable to control the spatial architecture and the encapsulated cell distribution precisely, which posed a significant challenge in constructing complex vascularized bone tissues with precise biomimetic properties. In recent years, as a pioneering technology, three-dimensional (3D) bioprinting technology has been applied to fabricate multiscale, biomimetic, multi-cellular tissues with a highly complex tissue microenvironment through layer-by-layer printing. This review discussed the application of 3D bioprinting technology in the vascularized tissue-engineered bone fabrication, where the current status and unique challenges were critically reviewed. Furthermore, the mechanisms of vascular formation, the process of 3D bioprinting, and the current development of bioink properties were also discussed.
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Weigand, Annika, Raymund E. Horch, Anja M. Boos, Justus P. Beier, and Andreas Arkudas. "The Arteriovenous Loop: Engineering of Axially Vascularized Tissue." European Surgical Research 59, no. 3-4 (2018): 286–99. http://dx.doi.org/10.1159/000492417.

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Background: Most of the current treatment options for large-scale tissue defects represent a serious burden for the patients, are often not satisfying, and can be associated with significant side effects. Although major achievements have already been made in the field of tissue engineering, the clinical translation in case of extensive tissue defects is only in its early stages. The main challenge and reason for the failure of most tissue engineering approaches is the missing vascularization within large-scale transplants. Summary: The arteriovenous (AV) loop model is an in vivo tissue engineering strategy for generating axially vascularized tissues using the own body as a bioreactor. A superficial artery and vein are anastomosed to create an AV loop. This AV loop is placed into an implantation chamber for prevascularization of the chamber inside, e.g., a scaffold, cells, and growth factors. Subsequently, the generated tissue can be transplanted with its vascular axis into the defect site and anastomosed to the local vasculature. Since the blood supply of the growing tissue is based on the AV loop, it will be immediately perfused with blood in the recipient site leading to optimal healing conditions even in the case of poorly vascularized defects. Using this tissue engineering approach, a multitude of different axially vascularized tissues could be generated, such as bone, skeletal or heart muscle, or lymphatic tissues. Upscaling from the small animal AV loop model into a preclinical large animal model could pave the way for the first successful attempt in clinical application. Key Messages: The AV loop model is a powerful tool for the generation of different axially vascularized replacement tissues. Due to minimal donor site morbidity and the possibility to generate patient-specific tissues variable in type and size, this in vivo tissue engineering approach can be considered as a promising alternative therapy to current treatment options of large-scale defects.
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Zor, Fatih. "Facial Vascularized Composite Tissue Allotransplantation." Gulhane Medical Journal 55, no. 2 (2013): 156. http://dx.doi.org/10.5455/gulhane.39844.

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Kian Kwan Oo, Kenneth, Wei Chen Ong, Annette Hui Chi Ang, Dietmar W. Hutmacher, and Luke Kim Siang Tan. "Tissue engineered prefabricated vascularized flaps." Head & Neck 29, no. 5 (2007): 458–64. http://dx.doi.org/10.1002/hed.20546.

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Levenberg, Shulamit, Jeroen Rouwkema, Mara Macdonald, Evan S. Garfein, Daniel S. Kohane, Diane C. Darland, Robert Marini, et al. "Engineering vascularized skeletal muscle tissue." Nature Biotechnology 23, no. 7 (July 2005): 879–84. http://dx.doi.org/10.1038/nbt1109.

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Acosta, Francisca M., Katerina Stojkova, Jingruo Zhang, Eric Ivan Garcia Huitron, Jean X. Jiang, Christopher R. Rathbone, and Eric M. Brey. "Engineering Functional Vascularized Beige Adipose Tissue from Microvascular Fragments of Models of Healthy and Type II Diabetes Conditions." Journal of Tissue Engineering 13 (January 2022): 204173142211093. http://dx.doi.org/10.1177/20417314221109337.

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Engineered beige adipose tissues could be used for screening therapeutic strategies or as a direct treatment for obesity and metabolic disease. Microvascular fragments are vessel structures that can be directly isolated from adipose tissue and may contain cells capable of differentiation into thermogenic, or beige, adipocytes. In this study, culture conditions were investigated to engineer three-dimensional, vascularized functional beige adipose tissue using microvascular fragments isolated from both healthy animals and a model of type II diabetes (T2D). Vascularized beige adipose tissues were engineered and exhibited increased expression of beige adipose markers, enhanced function, and improved cellular respiration. While microvascular fragments isolated from both lean and diabetic models were able to generate functional tissues, differences were observed in regard to vessel assembly and tissue function. This study introduces an approach that could be employed to engineer vascularized beige adipose tissues from a single, potentially autologous source of cells.
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Delaere, Pierre R., Robert Hermans, Jose Hardillo, and Bert Van Den Hof. "Prefabrication of Composite Tissue for Improved Tracheal Reconstruction." Annals of Otology, Rhinology & Laryngology 110, no. 9 (September 2001): 849–60. http://dx.doi.org/10.1177/000348940111000909.

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Tracheal repair tissues were evaluated experimentally to provide an evidence-based choice for decision-making in clinical tracheal reconstruction. Tracheal reconstructive tissue was characterized as providing for vascularization, support, and/or lining. A tissue equivalent was developed in the rabbit for each of the individual tissues. The individual tissues consisted of nonepithelialized soft tissue (vascularized fascia), epithelialized tissue (vascularized fascia grafted with buccal mucosa), and supportive tissue (ear cartilage). The 3 reconstructive tissues were evaluated in 30 rabbits after repair of an anterior laryngotracheal defect. Morphometric and histologic analysis was applied to the reconstructions. After a 1-month follow-up period, defects repaired with nonepithelialized soft tissue showed healing by secondary intention and a wound that was contracted to 44% of the initial surface area of the defect. Mucosa-lined soft tissue flaps and cartilage grafts showed a less than 10% wound contraction. Compared to cartilage grafts, mucosa-lined soft tissue (vascularized fascia grafted with buccal mucosa) seemed preferable for clinical use, because it showed healing by primary intention. A mucosa-lined radial forearm fascia flap was used successfully in cases of restenosis after tracheal resection. One deficiency of the mucosa-lined soft tissue was the absence of supportive tissue. In cases of extensive stenosis, it might be useful to obtain additional expansion of the airway lumen by creating a convexity at the site of reconstruction. In a second set of experiments, we attempted to improve the mucosa-lined soft tissue concept by adding elastic cartilage. A composite tissue consisting of vascularized fascia, buccal mucosa, and auricular cartilage was developed. Heterotopic prefabrication of the composite tissue was essential for survival of the cartilaginous component. Additional airway lumen expansion could be obtained after heterotopic flap prefabrication. After experimental evaluation, the concept of the prefabricated composite tissue was successfully applied in a clinical case of long-segment stenosis. Experimental and clinical evidence suggests that the combination of buccal mucosa and fascia form an optimized tissue combination for tracheal reconstruction. This combination can be improved by adding strips of autologous ear cartilage.
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Hong, Soyoung, Bo Young Jung, and Changmo Hwang. "Multilayered Engineered Tissue Sheets for Vascularized Tissue Regeneration." Tissue Engineering and Regenerative Medicine 14, no. 4 (July 3, 2017): 371–81. http://dx.doi.org/10.1007/s13770-017-0049-y.

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Dissertations / Theses on the topic "Vascularized tissue"

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Peticone, C. "Microscale tissue engineering : a modular approach for vascularized bone regeneration." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1547725/.

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Four million surgeries involving bone grafting or bone substitutes for the treatment of bone defects are performed yearly worldwide. However, limited donor tissue availability, pain and the risk of infection and immune rejection, have led to the development of alternative strategies for bone repair. Tissue engineering represents an alternative to current treatments as it consists of using a biomaterial scaffold alone or in combination with proteins, genes or cells, as a bioactive implant to stimulate bone repair. Microspherical scaffolds have been proposed as a potential modular unit for bone tissue engineering applications as their shape could facilitate filling of irregular shaped defects. Furthermore, microspheres could be used as a support for ex vivo expansion of adherent cells as well as a carrier to directly deliver cells to the defect site. In this study, the use of phosphate glass microcarriers for bone tissue engineering applications was investigated. As this material is completely soluble and non-toxic, it can be implanted in the patient together with cells. Furthermore, the tuneable glass composition can be easily engineered to induce specific structural and biological properties. Here, the effect of culturing MG-63 and hBM-MSCs on titanium-doped phosphate glass microspheres containing increasing concentration of cobalt (0, 2 and 5%) was investigated, as these ions have been shown to induce osteogenesis and angiogenesis, respectively. Furthermore, as part of this study a novel perfusion microfluidic bioreactor was fabricated to culture cells on microspheres under perfusion and to enable parallel screening of multiple culture variables. Cells proliferation on the microspheres as well as secretion of ECM proteins in response to the substrate was observed over time, thus confirming the biocompatibility of all compositions tested. Upregulation of osteogenic markers by MSCs also occurred in response to the microspheres in the absence of exogenous supplements. However, this effect was suppressed when cobalt was added to the glass composition. On the other hand, while cobalt doping was found to induce key angiogenic responses (i.e. VEGF secretion), this did not translate into improved functional vascularization in comparison to the cobalt-free microspheres. Successful MSCs culture on the microspheres within the microfluidic reactor was achieved and it was possible to efficiently quantify functional outputs, such as the expression of ECM proteins as a function of microspheres substrates and nutrient feeds under perfusion. In conclusion, titanium-doped phosphate glass microspheres were identified as a potential substrate for bone tissue engineering applications in terms of MSCs expansion and differentiation, as well as to support endothelial cells migration towards the scaffold and vessel formation, while additional doping with cobalt was not found to improve the functionality of the microspheres. Furthermore, the microfluidic bioreactor enabled to identify optimal parameters for perfused cell culture on microspheres that could be potentially translated to a scaled-up system for tissue-engineered bone manufacturing.
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Gkouma, Savvini. "Engineering Vascularized Skin Tissue in a 3D format supported by Recombinant Spider Silk." Thesis, KTH, Proteinteknologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-283605.

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Skin is an organ with a complex structure which plays a crucial role in thebody’s defence against external threats and in maintaining major homeostatic functions. The need for in vitro models that mimic the in vivo milieu is therefore high and relevant with various applications including, among others, penetration, absorption, and toxicity studies. In this context, the choice of the biomaterial that will provide a 3D scaffold to the cultured cells is defining the model’s success. The FN-4RepCT silk is here suggested as a potent biomaterial for skin tissue engineering applications. This recombinantly produced spider silk protein (FN-4RepCT), which can self-assemble into fibrils, creates a robust and elastic matrice with high bioactivity, due to its functionalization with the fibronectin derived RGD-containing peptide. Hence it overcomes the drawbacks of other available biomaterials either synthetic or based on animal derived proteins. Additionally, the FN-4RepCT silk protein can be cast in various 3D formats, two of which are utilized within this project. We herein present a bilayered skin tissue equivalent supported by the FN-4RepCT silk. This is constructed by the combination of a foam format, integrated with dermal fibroblasts and endothelial cells, and a membrane format supporting epidermal keratinocytes. As a result, a vascularized dermal layer that contains ECM components (Collagen I, Collagen III, and Elastin) is constructed and attached to an epidermal layer of differentiated keratinocytes.The protocol presented in this project offers a successful method of evenly integrating cells in the FN-4RepCT silk scaffold, while preserving their ability to resume some of their major in vivo functions like proliferation, ECM secretion, construction of vascular networks, and differentiation. The obtained results were evaluated with immunofluorescence stainings of various markers of interest and further analysed, when necessary, with image processing tools. The results that ensued from the herein presented protocol strongly suggest that the FN-4RepCT silk is a promising biomaterial for skin tissue engineering applications.
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Huber, Birgit [Verfasser], and Günter [Akademischer Betreuer] Tovar. "Development of culture media for the construction of vascularized adipose tissue and vascularized 3D full-skin equivalents in vitro / Birgit Huber ; Betreuer: Günter Tovar." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2016. http://d-nb.info/1123081085/34.

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Egerszegi, E. Patricia. "Experimental models in the primate for reconstructive surgery utilizing vascularized free tissue transplants with nerve repair." Thesis, McGill University, 1990. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22402.

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The aims of this project were to: (1) successfully design two models of reconstructive tissue transplants in the primate, one with a purely sensory nerve supply, the other a mixed sensory and motor supply and (2) achieve long enough survival for reinnervation to have occurred, assuming it can take place in the presence of the immunosuppressants.
A neurovascular free flap comprised of the entire soft tissue coverage of the second digit and a hand transplant model were successfully designed in the baboon (Papio hamadryas anubis). Seven transplanted neurovascular free flaps and four hand transplants were undertaken. High dose Cyclosporin A was found to be necessary to prevent rejection. Steroids proved to be a necessary part of the immunosuppressive regime. Nine out of 11 transplants survived to or beyond 4 months. In most cases, the end point was determined by the date for evaluation of reinnervation by our neurophysiologist colleagues and not loss of the transplant due to rejection.
Only 3 out of 11 transplants survived with little or no signs of rejection. All others had significant episodes of rejection, most of which were successfully reversed or controlled by using our rejection protocol. In addition, all animals, to varying degrees, demonstrated some of the following side effects: anorexia, anemia, gingival hyperplasia, hepatotoxicity, hirsutism, lymphoma, nephrotoxicity, subcutaneous or intramuscular abscesses and tremors. (Abstract shortened by UMI.)
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Schanz, Johanna E. "Etablierung einer biologischen vaskularisierten Matrix als Grundlage für ein in vitro Lebertestsystem Establishment of a biological vascularized scaffold as a basis for in vitro liver test system /." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:93-opus-34146.

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Kremer, Antje [Verfasser], Heike [Gutachter] Walles, Michael [Gutachter] Raghunath, Jörg [Gutachter] Teßmar, Kai [Gutachter] Fehske, and Iris [Gutachter] Ribitsch. "Tissue Engineering of a Vascularized Meniscus Implant / Antje Kremer ; Gutachter: Heike Walles, Michael Raghunath, Jörg Teßmar, Kai Fehske, Iris Ribitsch." Würzburg : Universität Würzburg, 2019. http://d-nb.info/1191102491/34.

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Werner, Katharina Julia [Verfasser], Lorenz [Gutachter] Meinel, and Torsten [Gutachter] Blunk. "Adipose Tissue Engineering - In vitro Development of a subcutaneous fat layer and a vascularized adipose tissue construct utilizing extracellular matrix structures / Katharina Julia Werner. Gutachter: Lorenz Meinel ; Torsten Blunk." Würzburg : Universität Würzburg, 2014. http://d-nb.info/1111508194/34.

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Tron, Alexandru-Cristian [Verfasser], Rainer H. H. [Akademischer Betreuer] [Gutachter] Burgkart, and Klaus-Dietrich [Gutachter] Wolff. "Decellularized whole organs as vascularized bioscaffolds for bone tissue engineering / Alexandru-Cristian Tron ; Gutachter: Klaus-Dietrich Wolff, Rainer H. H. Burgkart ; Betreuer: Rainer H. H. Burgkart." München : Universitätsbibliothek der TU München, 2016. http://d-nb.info/1118722140/34.

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Devillard, Chloé. "Développement de tissus vasculaires par bioimpression 3D." Thesis, Lyon, 2021. http://www.theses.fr/2021LYSE1339.

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Cette thèse a pour objectif de développer un tissu vasculaire par la méthode de bio-impression 3D de tissus vivants. Pour mener à bien ces travaux, une bioencre composée de trois biomatériaux naturels : la gélatine, l’alginate et le fibrinogène, a été formulée. Une amélioration du processus de fabrication d’un objet 3D par bio-impression ainsi que le développement d’une solution de consolidation spécifique, a permis le développement d’un réseau cellulaire en trois dimensions. L’utilisation particulière de milieu de culture à toutes les étapes de fabrication, de la préparation des biomatériaux à la consolidation de l’objet, a démontré une augmentation de la prolifération cellulaire de manière conséquente. Des caractérisations rhéologiques et histologiques ont été mises en place afin de démontrer cette prolifération augmentée. Afin de développer un tissu vasculaire, plusieurs approches technologiques ont été présentées, suivant un cahier des charges bien définit : (i) la technologie de biofabrication vasculaire tubulaire et (ii) la technologie de biofabrication vasculaire plane. Les méthodes de bio-impression 3D par micro-extrusion à 1 et 3 extrudeurs, la bio-impression 3D co-axial et tri-axial, la bio-impression 3D en milieu contraint, l’impression 4D par diffusion enzymatique, la bio-impression 3D par enroulement, ont ainsi été étudiées pour répondre à la création d’une structure tubulaire, multicouche et de taille centimétrique. La bio-impression 3D par micro-extrusion et la bio-impression 4D ont, quant à elles, été présentées pour répondre à la création d’une structure multicouche plane, biologiquement pertinente, mimant la paroi vasculaire composée d’une couche endothéliale, d’une couche de cellules musculaires lisses vasculaires et d’une couche de fibroblastes. La dernière partie de ce travail de thèse concerne les résultats de bio-impression, permettant de biofabriquer un tissu vascularisé. Une étude de l’impact des communications entre les fibroblastes et les cellules endothéliales, à l’intérieur d’un environnement 3D, sur le développement d’un réseau complexe, a été présentée. Un tissu vascularisé organisé par les cellules endothéliales à l’intérieur d’une matrice extracellulaire dense et néosynthétisée par les fibroblastes, a ainsi pu être mise en place en 7 jours. Des caractérisations histologiques ont mis en évidence la présence d’une micro-vascularisation et la technologie de microscopie électronique à transmission a permis de caractériser la formation de fibres de collagène et d’élastine, sécrétées par les fibroblastes
This thesis aims to develop a vascular tissue by the method of 3D bioprinting of living tissue. To carry out this work, a bioink composed of three natural biomaterials: gelatin, alginate, and fibrinogen, was formulated. An improvement in the manufacturing process of a 3D object by bioprinting as well as the development of a specific consolidation solution allowed the development of a three-dimensional cellular network. The particular use of culture medium at all stages of manufacture, from the preparation of the biomaterials to the consolidation of the object, has demonstrated a marked increase in cell proliferation. Rheological and histological characterizations were set up to demonstrate this increased proliferation. To develop vascular tissue, several technological approaches have been presented, following well-defined specifications: (i) tubular vascular biofabrication technology and (ii) planar vascular biofabrication technology. The methods of 3D bioprinting by micro-extrusion with 1 and 3 extruders, co-axial and tri-axial 3D bioprinting, 3D bioprinting in a constrained environment, 4D printing by enzymatic diffusion, bio- 3D printing by winding, have thus been studied to respond to the creation of a tubular, multilayer structure of centimeter size. Micro-extrusion 3D bioprinting and 4D bioprinting were presented to respond to the creation of a planar multilayer structure, biologically relevant, mimicking the vascular wall composed of an endothelial layer, d 'a layer of vascular smooth muscle cells, and a layer of fibroblasts. The last part of this thesis concerns the results of bioprinting, allowing to biofabricate a vascularized tissue. A study of the impact of communications between fibroblasts and endothelial cells, within a 3D environment, on the development of a complex network, was presented. A vascularized tissue organized by endothelial cells inside a dense extracellular matrix and neosynthesized by fibroblasts could thus be placed in 7 days. Histological characterizations demonstrated the presence of micro-vascularization and transmission electron microscopy technology characterized the formation of collagen and elastin fibers, secreted by fibroblasts
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Volz, Ann-Cathrin Verfasser], and Petra Juliane [Akademischer Betreuer] [Kluger. "Establishment of defined culture conditions for the differentiation, long-term maintenance and co-culture of adipose-derived stem cells for the setup of human vascularized adipose tissue / Ann-Cathrin Volz ; Betreuer: Petra Juliane Kluger." Hohenheim : Kommunikations-, Informations- und Medienzentrum der Universität Hohenheim, 2019. http://d-nb.info/1176020617/34.

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Books on the topic "Vascularized tissue"

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M, Collins G., ed. Procurement, preservation, and allocation of vascularized organs. Dordrecht: Kluwer Academic, 1997.

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Collins, G. M. Procurement, Preservation and Allocation of Vascularized Organs. Springer, 2012.

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Leung, Brendan Martin Pue-Bun. A modular vascularized tissue engineering construct containing smooth muscle cells and endothelial cells. 2006.

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Sabapathay, S. Raja, and Roderick Dunn. Reconstruction. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198757689.003.0007.

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The principles of upper limb reconstruction are to perform careful wound excision, fix the skeleton, reconstruct vessels, nerves, tendons, and bone as required (either immediate or delayed), and to obtain primary healing of the soft tissues with healthy vascularized tissue. This enables early movement—ideally, supervised by hand therapists—and generally results in a good outcome. In particular, delayed healing and immobility can lead to long-term morbidity. We provide a general overview of the principles of surgical incisions in the hand, wound care, and suturing, and discuss the use of skin grafts and flaps in the upper limb. We describe reconstruction of the different areas of the upper limb, along with detailed sections on digital and thumb reconstruction.
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Osman, Nadir I., and Christopher R. Chapple. Urinary fistula. Edited by Christopher R. Chapple. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199659579.003.0041.

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Genitourinary fistulae (GuF) are one of the oldest described causes of incontinence. They are associated with significant social and psychological debilitation. In developed countries, they most commonly occur after iatrogenic injury to the urinary tract during gynaecological surgery for benign conditions, whereas in developing countries the most common cause remains prolonged obstetric labour. The most frequent type of GuF occurs between the bladder and vagina. GuF require careful evaluation to confirm the diagnosis and assess the number, location, and anatomy of defects, as well as any associated injuries before operative management is undertaken. The surgical approach to each fistula is individualized and relies upon the use of healthy vascularized tissue to repair defects, preferably with interposition of a tissue flap to augment repairs.
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McGuigan, Alison P. Design and fabrication of a modular vascularised tissue-engineered construct. 2005.

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Book chapters on the topic "Vascularized tissue"

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Diefenbeck, Michael, and Gunther O. Hofmann. "Vascularized Knee Transplantation." In Transplantation of Composite Tissue Allografts, 293–306. Boston, MA: Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-74682-1_21.

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Otterburn, David, and Linda C. Cendales. "Vascularized Composite Allotransplantation." In Tissue and Cell Clinical Use, 302–11. Oxford, UK: Wiley-Blackwell, 2012. http://dx.doi.org/10.1002/9781118498453.ch14.

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Tai, Chau Y., Louise F. Strande, Hidetoshi Suzuki, Martha S. Matthews, Chad R. Gordon, and Charles W. Hewitt. "Vascularized Bone Marrow Transplantation." In Transplantation of Composite Tissue Allografts, 253–71. Boston, MA: Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-74682-1_18.

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Smart, Chandra, and Kourosh Beroukhim. "Vascularized Composite Tissue Transplant Pathology." In Practical Atlas of Transplant Pathology, 153–60. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-23054-2_7.

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Obuseh, Favour, Christina Jones, and Eric M. Brey. "Strategies for 3D Printing of Vascularized Bone." In Bone Tissue Engineering, 249–65. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-92014-2_11.

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Klein, Silvan M., Jody Vykoukal, Lukas Prantl, and Juergen H. Dolderer. "Tissue Engineering of Vascularized Adipose Tissue for Soft Tissue Reconstruction." In Stem Cells in Aesthetic Procedures, 23–40. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-45207-9_3.

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Cheng, Hai-Ling Margaret. "MRI of Vascularized Tissue-Engineered Organs." In Magnetic Resonance Imaging in Tissue Engineering, 311–31. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2017. http://dx.doi.org/10.1002/9781119193272.ch14.

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Olszewski, Waldemar L., and Marek Durlik. "Immune Cell Redistribution After Vascularized Bone Marrow Transplantation." In Transplantation of Composite Tissue Allografts, 278–89. Boston, MA: Springer US, 2008. http://dx.doi.org/10.1007/978-0-387-74682-1_20.

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Delaere, Pierre R. "Other Vascularized Reconstructive Tissue for Laryngeal Repair." In Laryngotracheal Reconstruction, 245–57. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18684-4_7.

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Akar, Banu, and Eric M. Brey. "Cell-Based Approaches for Vascularized Tissue Formation." In Biomaterials for Cell Delivery, 85–106. Boca Raton : Taylor & Francis, 2018. | Series: Gene and cell therapy series: CRC Press, 2018. http://dx.doi.org/10.1201/9781315151755-4.

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Conference papers on the topic "Vascularized tissue"

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Böker, K., S. Siegk, M. Remling, J. Wagner, J. Liu, W. Lehmann, and Schilling AF. "Vascularized 3D-bone and cartilage tissue engineering." In Jahreskongress DVO OSTEOLOGIE 2021. Georg Thieme Verlag KG, 2021. http://dx.doi.org/10.1055/s-0040-1722116.

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Marshall, Lauren, Andra Frost, Tim Fee, and Joel Berry. "Assembly and Characterization of 3D, Vascularized Breast Cancer Tissue Mimics." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14199.

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Drug development platforms such as two-dimensional (2D) in vitro cell culture systems and in vivo animal studies do not accurately predict human in vivo effectiveness of candidate therapeutics [1]. Cell culture systems have limited similarities to primary human cells and tissues as only one cell type is employed and animal studies have a generally limited ability to recapitulate human drug response as different species have differences in metabolism, physiology, and behavior. Mike Leavitt, a former U.S. Secretary of Health and Human Services, has stated that “currently, nine out of ten experimental drugs fail in clinical studies because we cannot accurately predict how they will behave in people based on laboratory and animal studies” [2]. Therefore, this research project is focused on developing an in vitro platform to test candidate therapeutics for more efficacious predictions of human response. We have fabricated a three-dimensional (3D) breast cancer tissue volume containing a vascular network. This vascular network is necessary because current in vitro systems (e.g., rotating bioreactors, suspension of spheroids, and growth on a porous scaffold) are limited in size (1–2 mm) by their absence of micrometer-scale blood flow micro-channels that allow for oxygen and nutrient diffusion into the tissue [4]. The extracellular matrix scaffold has been developed to mimic the native extracellular matrix and includes relevant cell types (e.g., human breast cancer epithelial cells and human breast fibroblasts) along with the prefabricated vascular network (prevascularization). These systems are intended to support long-term growth, recapitulate physiological tissue function, and accurately model response to treatment. It is hypothesized that the development of reproducible tissue volumes will transform breast cancer drug development by providing reliable, cost-effective models that can more accurately predict therapeutic efficacy than current preclinical in vivo and in vitro models.
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Shabudin, Abbas, Mohd Jamil Mohamed Mokhtarudin, Stephen Payne, and Nik Abdullah Nik Mohamed. "Application of Asymptotic Expansion Homogenization for Vascularized Poroelastic Brain Tissue." In 2018 IEEE-EMBS Conference on Biomedical Engineering and Sciences (IECBES). IEEE, 2018. http://dx.doi.org/10.1109/iecbes.2018.8626727.

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Gong, Haibo, Qingwei Zhang, Peter I. Lelkes, Jack G. Zhou, and Dichen Li. "Biomimetic Design, Modeling and Manufacturing of Chitosan/Gelatin Scaffolds for 3D Vascularized Liver Tissue Construct." In ASME 2010 International Manufacturing Science and Engineering Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/msec2010-34277.

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Despite the significant progress in engineering fairly thin tissues that contain or acquire vascular structures (e.g. skin, cartilage and bladder), it has been markedly difficult to construct metabolically demanding organs with thicker and more complex structures (e.g. heart, lung, kidney, and liver). This research explores a new generation of clinically significant (500cm3) liver tissue constructs made of a new natural polymer composite, imbedded with optimized network of flow channels, and manufactured using innovative structured porogen and lost-wax molding methods to receive a 3D vascularized liver tissue construct. Biomimetic designed liver scaffolds with 3D network of flow channels were optimized based on simulation of fluid flow inside the channel network. Combining structured porogen method, lost-wax molding and freeze-drying technique, both macro (1 cm) and the micro (500μm) scale structures were achieved in chitosan/gelatin liver scaffolds. Liver parenchymal cells were seeded in the 3D scaffolds and cultured for 3 days. Evident cell growth was found both at the bottom and the center of the scaffolds, which indicates the biocompatibility is maintained through the manufacturing process and 3D channels improved cell in-growth.
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Park, Seungman, Catherine Whittington, Mervin C. Yoder, Sherry Voytik-Harbin, and Bumsoo Han. "Effects of Collagen Microstructure on the Transport Properties of Vascularized Engineered Tissues." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80817.

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When vascular perfusion is compromised within the body, a number of physiological phenomena can occur, including the progression of disease states (e.g. peripheral vascular disease), impaired wound healing, and organ/tissue transplant failure. Therefore, there is a need for an engineered tissue construct that promotes therapeutic vasculogenesis by enhancing the formation of functional, stabilized vessel networks that have the ability to integrate with the host vasculature. In order to restore tissue structure and function, a matrix-based delivery system, which combines a biopolymer and endothelial precursor cells, is necessary to ensure the localization and guidance of vessel formation and stabilization.
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Itai, Shun, and Hiroaki Onoe. "Thin Layered Heterogeneous Vascularized 3D Tissue Models Constructed with Separated-Layer Collagen Microtube." In 2019 IEEE 32nd International Conference on Micro Electro Mechanical Systems (MEMS). IEEE, 2019. http://dx.doi.org/10.1109/memsys.2019.8870866.

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Liu, Jing. "Analogy Between Heat and Mass Transfer Leads to New Oxygen Transport Equations in Vascularized Biological Tissues." In ASME 2004 International Mechanical Engineering Congress and Exposition. ASMEDC, 2004. http://dx.doi.org/10.1115/imece2004-61102.

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Mathematical modeling of oxygen transport in living tissues has been an important approach for quantitatively understanding the physiological events. In a vascularized biological tissue, blood flow plays an important role in the local transport of oxygen, nutrients, pharmaceuticals, waste products and heat through the body. However, most of the existing oxygen transport models take few considerations of the anatomical structure. Therefore, disagreements among the theoretical predictions and the experimental measurements are common in those studies. This is because geometrical irregularity of the vascular structure remained to be a major obstacle for the accurate modeling. In fact, it has long been a desirable objective to establish a quantitative and generalized model, which is mathematically tractable in the region of interest and considering the detailed anatomical vascular geometry. In this paper, following the theoretical strategy through analogy between the heat and mass transport, the well-established Pennes equation, Chen-Holmes equation, and Weinbaum-Jiji (W-J) equation, etc. were implemented to develop the basic equations for characterizing the oxygen transport inside a vascularized tissue. These models have collectively included the contributions of the vascular geometry and the blood flow condition. As an illustration, predictions using the new model from W-J equation on several typical oxygen transfer problems were discussed. The theoretical results were applied to interpret some previous experimental observations. Further, uncertainties for the predicted oxygen concentrations of tissues due to approximate parameters and vascular structures were analyzed based on developing a generalized equation. Contributions from each of the thermal parameters such as diffusion coefficient, blood perfusion rate, and oxygen consumption rate of the tissues etc. can all be attributed to a single source term, which would make the model much convenient for practical use. The theoretical route proposed in this paper may provide a feasible way to comprehensively characterize the oxygen transport behaviors in living tissues with complex vasculature. It can also be extended to more wide mass transfer issues such as drug and nutrients delivery etc.
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Yeager, Michael E., Kelley L. Colvin, Dmitry D. Belchenko, Meheret Nega, Carlos Barajas, Patrick J. Cripe, Dunbar D. Ivy, and Kurt Stenmark. "Immunologically Active And Well-Vascularized Bronchus-Associated Lymphoid Tissue Is Evident In Pulmonary Hypertension." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a1325.

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Mann, Henning, and Anne Grosse-Wilde. "Abstract LB-045: A tissue-engineered vascularized tumor microenvironment for preclinical testing of anticancer therapeutics." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-lb-045.

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Cahn, Frederick. "Materials Processing Technology for an Acellular Artificial Skin." In ASME 2000 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2000. http://dx.doi.org/10.1115/imece2000-2508.

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Abstract Artificial skin is a bilayer skin replacement system designed to regenerate dermal tissue. Prior to the commercial availability of artificial skin, surgically created wounds that cannot be closed by primary means (such as excising deep partial or full-thickness burns), had to be treated with autograft; a graft of the patient’s own skin harvested from a healthy donor site. This is because the dermal layer of skin cannot regenerate functional tissue spontaneously; instead, scar tissue forms. When applied surgically to a clean, excised wound bed, autograft becomes permanently engrafted, that is, it becomes permanently affixed to the underlying tissue and vascularized. However, autograft has serious drawbacks, including the creation of a donor wound, which has its own significant morbidity, and its unavailability in sufficient quantity in patients with large wounds.
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Reports on the topic "Vascularized tissue"

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Griffith, Linda G., S. R. Tannenbaum, J. Wands, J. Sherley, and D. Schaver. Vascularized Tissue Sensors for Generic Toxin and Pathogen Detection. Fort Belvoir, VA: Defense Technical Information Center, December 2004. http://dx.doi.org/10.21236/ada428591.

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