Journal articles: 'Vascular event'

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Lin, Yi-Ting, and Ping-Hsun Wu. "Vascular Event Risk After Herpes Zoster." Mayo Clinic Proceedings 94, no. 8 (August 2019): 1649–50. http://dx.doi.org/10.1016/j.mayocp.2019.05.029.

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de Mornac, Donatienne, Christian Agard, Jean-Benoit Hardouin, Mohamed Hamidou, Jérôme Connault, Agathe Masseau, Alexandra Espitia-Thibault, et al. "Risk factors for symptomatic vascular events in giant cell arteritis: a study of 254 patients with large-vessel imaging at diagnosis." Therapeutic Advances in Musculoskeletal Disease 13 (January 2021): 1759720X2110069. http://dx.doi.org/10.1177/1759720x211006967.

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Aims: To identify factors associated with vascular events in patients with giant cell arteritis (GCA). Methods: We performed a retrospective study of GCA patients diagnosed over a 20-year-period, who all underwent vascular imaging evaluation at diagnosis. Symptomatic vascular events were defined as the occurrence of any aortic event (aortic dissection or symptomatic aortic aneurysm), stroke, myocardial infarction, limb or mesenteric ischemia and de novo lower limbs arteritis stage 3 or 4. Patients with symptomatic vascular event (VE+) and without were compared, and risk factors were identified in a multivariable analysis. Results: Thirty-nine (15.4%) of the 254 included patients experienced at least one symptomatic vascular event during follow-up, with a median time of 21.5 months. Arterial hypertension, diabetes, lower limbs arteritis or vascular complication at diagnosis were more frequent in VE+ patients ( p < 0.05), as an abnormal computed tomography (CT)-scan at diagnosis ( p = 0.04), aortitis ( p = 0.01), particularly of the descending thoracic aorta ( p = 0.03) and atheroma ( p = 0.03). Deaths were more frequent in the VE+ group (37.1 versus 10.3%, p = 0.0003). In multivariable analysis, aortic surgery [hazard ratio (HR): 10.46 (1.41–77.80), p = 0.02], stroke [HR: 22.32 (3.69–135.05), p < 0.001], upper limb ischemia [HR: 20.27 (2.05–200.12), p = 0.01], lower limb ischemia [HR: 76.57 (2.89–2027.69), p = 0.009], aortic atheroma [HR: 3.06 (1.06–8.82), p = 0.04] and aortitis of the descending thoracic aorta on CT-scan at diagnosis [HR: 4.64 (1.56–13.75), p = 0.006] were independent predictive factors of a vascular event. Conclusion: In this study on GCA cases with large vessels imaging at diagnosis, aortic surgery, stroke, upper or lower limb ischemia, aortic atheroma and aortitis of the descending thoracic aorta on CT-scan, at GCA diagnosis, were independent predictive factors of a vascular event. Plain language summary Risk factors for symptomatic vascular events in giant cell arteritis This study was performed to identify the risk factors for developing symptomatic vascular event during giant cell arteritis (GCA) because these are poorly known. We performed a retrospective study of GCA patients diagnosed over a 20-year-period, who all underwent vascular imaging evaluation at diagnosis. Patients with symptomatic vascular event (VE+) and without (VE-) were compared, and risk factors were identified in a multivariable analysis. Thirty-nine patients experienced at least one symptomatic vascular event during follow-up, with a median time of 21.5 months. Arterial hypertension, diabetes, lower limbs arteritis or vascular complication at diagnosis were significantly more frequent in VE+ patients, as an abnormal CT-scan at diagnosis, aortitis, particularly of the descending thoracic aorta and atheroma. Deaths were more frequent in the VE+ group. Among 254 GCA patients, 39 experienced at least one vascular event during follow-up. Aortic surgery, stroke, upper and lower limb ischemia were vascular event risk factors. Aortic atheroma and descending thoracic aorta aortitis on CT-scan were vascular event risk factors. This study on GCA cases with large vessels imaging at diagnosis, showed that aortic surgery, stroke, upper or lower limb ischemia, aortic atheroma and aortitis of the descending thoracic aorta on CT-scan, at GCA diagnosis, were independent predictive factors of a vascular event.

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Ridker, Paul M., and Jagat Narula. "Will Reducing Inflammation Reduce Vascular Event Rates?" JACC: Cardiovascular Imaging 11, no. 2 (February 2018): 317–19. http://dx.doi.org/10.1016/j.jcmg.2017.10.001.

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Cooke, Ian J., Leslie M. Okorji, Richard S. Matulewicz, Daniel T. Oberlin, and Brian T. Helfand. "Bladder Pneumatosis From a Catastrophic Vascular Event." Urology Case Reports 8 (September 2016): 58–60. http://dx.doi.org/10.1016/j.eucr.2016.07.002.

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Frank, Samuel, and Richard Barbano. "Trauma-induced spinal vascular event producing hemipseudoathetosis." Movement Disorders 20, no. 10 (October 2005): 1378–80. http://dx.doi.org/10.1002/mds.20518.

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Roberto, Giuseppe, Carlo Piccinni, Roberto D’Alessandro, and Elisabetta Poluzzi. "Triptans and serious adverse vascular events: Data mining of the FDA Adverse Event Reporting System database." Cephalalgia 34, no. 1 (August 6, 2013): 5–13. http://dx.doi.org/10.1177/0333102413499649.

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Aim The aim of this article is to investigate the vascular safety profile of triptans through an analysis of the United States Food and Drug Administration Adverse Event Reporting System (FDA_AERS) database with a special focus on serious and unexpected adverse events. Methods A case/non-case analysis was performed on the reports entered in the FDA_AERS from 2004 to 2010: Cases were reports with at least one event included in the MedDRA system organ classes ‘Cardiac disorder’ or ‘Vascular disorders’, whereas non-cases were all the remaining reports. Co-reported cardiovascular drugs were used as a proxy of cardiovascular risk and the adjusted reporting odds ratio (adj.ROR) with 95% confidence intervals (95% CI) was calculated. Disproportionality signals were defined as adj.ROR value >1. Adverse events were considered unexpected if not mentioned on the relevant label. Results Among 2,131,688 reports, 7808 concerned triptans. Cases were 2593 among triptans and 665,940 for all other drugs. Unexpected disproportionality signals were found in the following high-level terms of the MedDRA hierarchy: ‘Cerebrovascular and spinal necrosis and vascular insufficiency’ (103 triptan cases), ‘Aneurysms and dissections non-site specific’ (15), ‘Pregnancy-associated hypertension’ (10), ‘Reproductive system necrosis and vascular insufficiency’ (3). Discussion Our analysis revealed three main groups of unexpected associations between triptans and serious vascular events: ischaemic cerebrovascular events, aneurysms and artery dissections, and pregnancy-related vascular events. A case-by-case assessment is needed to confirm or disprove their plausibility and large-scale analytical studies should be planned for risk rate estimation. In the meantime, clinicians should pay special attention to migraine diagnosis and vascular risk assessment before prescribing a triptan, also promptly reporting any unexpected event to pharmacovigilance systems.

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Bellolio, M. F., L. Vaidyanathan, S. Enduri, R. Kayshap, R. Gilmore, A. Bhagra, W. W. Decker, and L. G. Stead. "Subsequent Vascular Event Following an Acute Ischemic Stroke." Academic Emergency Medicine 14, no. 5 Supplement 1 (May 1, 2007): S29—S30. http://dx.doi.org/10.1197/j.aem.2007.03.771.

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Patterson, Brandon J., Debora A. Rausch, Debra E. Irwin, and Barbara P. Yawn. "In reply—Vascular Event Risk After Herpes Zoster." Mayo Clinic Proceedings 94, no. 8 (August 2019): 1650–51. http://dx.doi.org/10.1016/j.mayocp.2019.05.028.

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Khan, Hasan Ali, Rashed al-Hamdan, Adnan al-Asousi, and Aiad-Al Anzi. "Multiorgan Vascular Event Due to Left Atrial Myxoma." American Journal of Geriatric Cardiology 16, no. 5 (May 2007): 323–24. http://dx.doi.org/10.1111/j.1076-7460.2007.05202.x.

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Tangelder, Marco J. D., James A. Lawson, Frans L. Moll, Ale Algra, and Eline S. Van Hattum. "Long-term risk of vascular events after peripheral bypass surgery." Thrombosis and Haemostasis 108, no. 09 (2012): 543–53. http://dx.doi.org/10.1160/th11-12-0844.

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SummaryPatients with peripheral arterial disease (PAD) are at high risk of major ischaemic events. Long-term data of all major ischaemic events in PAD patients are scarce and outdated, especially for patients with severe PAD requiring bypass surgery. Our objective was to define their longterm prognosis and develop a prediction model which quantifies this risk up to a decade after surgery. We conducted a retrospective cohort study in patients from the Dutch Bypass Oral anticoagulants or Aspirin (BOA) Study; a multicentre randomised trial comparing oral anticoagulants with aspirin after infrainguinal bypass surgery. The primary outcome was the composite event of nonfatal myocardial infarction, non-fatal ischaemic stroke, major amputation, and vascular death. Cumulative risks were assessed by Kaplan-Meier analysis and independent determinants by multivariable Cox regression models. From 1995 until 2009, 482 patients were followed for a median period of 7.8 years. Follow-up was complete in 94%. Overall 60% of patients experienced a primary outcome event, of which the majority was a vascular death (30%), followed by major amputations (12%). The primary cause of vascular death was a cardiovascular event (29%), whereas the minority was due to complications directly related to PAD (6%). Within five years after bypass surgery vascular death occurred in about a quarter of patients and within 10 years in nearly half of patients. This was double the rate as for non-vascular death. The primary outcome event occurred in over a third and over half of patients in 5 and 10 years after bypass surgery, respectively. From four independent determinants for the primary outcome event: age, diabetes, critical limb ischaemia, and prior vascular interventions, we developed a risk chart, which systematically classifies the 10-year risks of the primary outcome event, ranging from 25% to 85%. This study provided a detailed insight in the course of PAD long after peripheral bypass surgery and enables individual risk assessment of major fatal and non-fatal ischaemic events by means of cumulative incidences and a risk chart.

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de Vries, Tamar Irene, Jan Westerink, Michiel L. Bots, Folkert W. Asselbergs, Yvo M. Smulders, and Frank L. J. Visseren. "Relationship between classic vascular risk factors and cumulative recurrent cardiovascular event burden in patients with clinically manifest vascular disease: results from the UCC-SMART prospective cohort study." BMJ Open 11, no. 3 (March 2021): e038881. http://dx.doi.org/10.1136/bmjopen-2020-038881.

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ObjectiveThe aim of the current study was to assess the relationship between classic cardiovascular risk factors and risk of not only the first recurrent atherosclerotic cardiovascular event, but also the total number of non-fatal and fatal cardiovascular events in patients with recently clinically manifest cardiovascular disease (CVD).DesignProspective cohort study.SettingTertiary care centre.Participants7239 patients with a recent first manifestation of CVD from the prospective UCC-SMART (Utrecht Cardiovascular Cohort - Second Manifestations of ARTerial disease) cohort study.Outcome measuresTotal cardiovascular events, including myocardial infarction, stroke, vascular interventions, major limb events and cardiovascular mortality.ResultsDuring a median follow-up of 8.9 years, 1412 patients had one recurrent cardiovascular event, while 1290 patients had two or more recurrent events, with a total of 5457 cardiovascular events during follow-up. The HRs for the first recurrent event and cumulative event burden using Prentice-Williams-Peterson models, respectively, were 1.36 (95% CI 1.25 to 1.48) and 1.26 (95% CI 1.17 to 1.35) for smoking, 1.14 (95% CI 1.11 to 1.18) and 1.09 (95% CI 1.06 to 1.12) for non-high-density lipoprotein (HDL) cholesterol, and 1.05 (95% CI 1.03 to 1.07) and 1.04 (95% CI 1.03 to 1.06) for systolic blood pressure per 10 mm Hg.ConclusionsIn a cohort of patients with established CVD, systolic blood pressure, non-HDL cholesterol and current smoking are important risk factors for not only the first, but also subsequent recurrent events during follow-up. Recurrent event analysis captures the full cumulative burden of CVD in patients.

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Ramadan, Moustapha Ahmed, and Gautam Hebbar. "A Retrospective Analysis of Dialysis Events over a 3-Year Period in an Outpatient Dialysis Unit in the State of Kuwait." Medical Principles and Practice 27, no. 4 (2018): 337–42. http://dx.doi.org/10.1159/000486595.

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Objective: To determine the difference in the rates of dialysis events stratified by vascular access type and to describe the microbiological profile and sensitivity patterns of positive blood cultures over a 3-year period. Subjects and Methods: The dialysis event data of 10,751 chronic hemodialysis patients collected from March 2013 to February 2016 at an outpatient dialysis unit in Kuwait were reviewed. The dialysis events studied were: intravenous (IV) antimicrobial use, a positive blood culture, and signs of inflammation at the vascular access site. Dialysis event rates were stratified by the type of vascular access used for the dialysis, i.e., fistula, graft, and tunneled/nontunneled central line. Rates were expressed per 100 patient-months. Results: The overall dialysis event rate was (10.7/100 patient-months). The rate of IV antimicrobial use was higher (12.53/100 patient-months) in patients with tunneled central lines than in all other vascular access types (10.29/100 patient-months). Positive blood culture and inflammation at the vascular access site were highest in patients with nontunneled central lines (1.65 and 1.54/100 patient-months, respectively) when compared to those with other types of vascular access. Gram-negative rod isolates were predominant in patients with central lines (n = 35; 46.67%); however, common skin commensals and gram-negative rods were also identified in patients with fistula or graft (n = 4; 44.45%). Conclusion: Dialysis event rates were higher among patients with tunneled or nontunneled central lines than in patients with fistula or graft. Gram-negative rods were the most commonly isolated microbial group.

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Tilikete, Caroline, and Alain Vighetto. "When is diplopia strongly suggestive of a vascular event?" Expert Review of Ophthalmology 4, no. 4 (August 2009): 357–61. http://dx.doi.org/10.1586/eop.09.28.

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Silacci, P., and D. Hayoz. "Oxidative stress as the triggering event for vascular remodelling." Nephrology Dialysis Transplantation 13, no. 6 (June 1, 1998): 1343–46. http://dx.doi.org/10.1093/oxfordjournals.ndt.a027888.

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D'Elia, J. "Risk factors and vascular event history in hemodialysis patients." American Journal of Hypertension 14, no. 11 (November 2001): A59. http://dx.doi.org/10.1016/s0895-7061(01)01627-2.

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Wilterdink, J. L., and J. D. Easton. "Vascular Event Rates in Patients With Atherosclerotic Cerebrovascular Disease." Archives of Neurology 49, no. 8 (August 1, 1992): 857–63. http://dx.doi.org/10.1001/archneur.1992.00530320089016.

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Duwayri, Yazan, Jonathan Goss, William Knechtle, Ravi K. Veeraswamy, Shipra Arya, Ravi R. Rajani, Luke P. Brewster, Thomas F. Dodson, and John F. Sweeney. "The Readmission Event after Vascular Surgery: Causes and Costs." Annals of Vascular Surgery 36 (October 2016): 7–12. http://dx.doi.org/10.1016/j.avsg.2016.02.024.

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Yáñez-Espinosa, Laura, Teresa Terrazas, and Lauro López-Mata. "Phenology and radial stem growth periodicity in evergreen subtropical rainforest trees." IAWA Journal 31, no. 3 (2010): 293–307. http://dx.doi.org/10.1163/22941932-90000024.

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A close relationship between leafing, flowering, fruiting and radial growth has been conjectured to occur in tropical and subtropical rainforest trees. Radial stem growth, in particular, has been associated with the activity of the two secondary meristems, the vascular cambium and, to a lesser degree, the phellogen. In tropical trees vascular cambium activity may occur either virtually year-round, or it may be restricted to a short season. Phellogen and vascular cambium activities may or may not correspond to each other. In subtropical environments, even evergreens may demonstrate seasonal phenology in leaf initiation, flowering and seed set. In the present study, phenological events were analyzed in the evergreen species Aphananthe monoica, Pleuranthodendron lindenii and Psychotria costivenia. A correlation analysis showed that more than half of the variation is shared by phenological event variables (leafing, flowering and fruiting) and radial growth variables (vascular cambium and phellogen activity, and vascular tissue differentiation). Leaf initiation, flowering and vascular cambium activation were the most closely-related simultaneous events during the summer; whereas fruiting, phellogen activity and vascular tissue differentiation were the most closely-related simultaneous events during the summer and fall. This could explain why the leaf initiation and expansion stages, which produce growth regulators, are directly involved in radial growth.

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Chen, Yan-Yan, Zu-Sen Ye, Nian-Ge Xia, and Yun Xu. "TMAO as a Novel Predictor of Major Adverse Vascular Events and Recurrence in Patients with Large Artery Atherosclerotic Ischemic Stroke." Clinical and Applied Thrombosis/Hemostasis 28 (January 2022): 107602962210905. http://dx.doi.org/10.1177/10760296221090503.

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Objectives To explore the association of plasma trimethylamine N-oxide (TMAO) concentration with large artery atherosclerotic (LAA) ischemic stroke and its role in predicting neurological outcome and major vascular event recurrence. Materials and Methods We performed a case-control study that included patients with first-ever LAA stroke as cases (n = 291) and asymptomatic patients as controls (n = 235). Clinical data and venous blood samples were collected within 72 hours after stroke. All subjects were followed for 3 months. TMAO level was detected by liquid chromatography mass spectrometry (LC-MS). Logistic and Cox proportional hazard regression were performed to evaluate plasma TMAO concentration as a predictor of LAA stroke and major vascular event recurrence, respectively. Kaplan–Meier survival analysis was performed to compare major vascular event recurrence between patients with high and low TMAO concentration. Results After adjusting for traditional stroke risk factors, the plasma TMAO level was significantly higher in the LAA stroke group than the control group (OR = 1.031, 95% CI 1.024-1.037, P < .001). At a cutoff level of 106.9 pg/ml, TMAO had a sensitivity of 63.23% and specificity of 80.00% in discriminating the LAA stroke subjects from the controls in Receiver operator characteristic (ROC) analysis. Kaplan–Meier survival analysis demonstrated TMAO plasma concentration was significantly relevant with recurrent vascular events (Log Rank, P = .006). Moreover, this association was still existed after adjusting for traditional risks (adjusted HR, 3.128; 95% CI, 1.018-9.610) in Cox regression model. But TMAO plasma levels were not relevant with functional disability after 3 months of the LAA stroke. Conclusion Elevated plasma TMAO concentration was independently associated with LAA ischemic stroke. The risk of major vascular event recurrence increased by 2.128 times in the LAA stroke subjects with plasma TMAO level higher than 126.83 pg/mL. Plasma TMAO concentration might be a potential biomarker of major vascular event recurrence.

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Davi, Giovanni, Marco Proietti, Daniele Pastori, William R. Hiatt, Gino Roberto Corazza, Francesco Perticone, Pasquale Pignatelli, et al. "Ankle-Brachial Index and cardiovascular events in atrial fibrillation." Thrombosis and Haemostasis 115, no. 04 (2016): 856–63. http://dx.doi.org/10.1160/th15-07-0612.

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SummaryAtrial fibrillation (AF) patients are at high risk for thrombotic and vascular events related to their cardiac arrhythmia and underlying systemic atherosclerosis. Ankle-Brachial Index (ABI) is a non-invasive tool in evaluating systemic atherosclerosis, useful in predicting cardiovascular events in general population; no data are available in AF patients. ARAPACIS is a prospective multicentre observational study performed by the Italian Society of Internal Medicine, analysing association between low ABI (≤0.90) and vascular events in NVAF out- or in-patients, enrolled in 136 Italian centres. A total of 2,027 non-valvular AF (NVAF) patients aged > 18 years from both sexes followed for a median time of 34.7 (interquartile range: 22.0–36.0) months, yielding a total of 4,614 patient-years of observation. Mean age was 73 ± 10 years old with 55% male patients. A total of 176 patients (8.7%) experienced a vascular event, with a cumulative incidence of 3.81%/patient-year. ABI≤ 0.90 was more prevalent in patients with a vascular event compared with patients free of vascular events (32.2 vs 20.2%, p< 0.05). On Cox proportional hazard analysis, ABI≤ 0.90 was an independent predictor of vascular events (hazard ratio (HR): 1.394, 95% confidence interval (CI): 1.042–1.866; p=0.02), vascular death (HR: 2.047, 95% CI: 1.255-3.338; p=0.004) and MI (HR: 2.709, 95%> CI: 1.485-5.083; p=0.001). This latter association was also confirmed after excluding patients with previous MI (HR: 2.901, 95% CI: 1.408-5.990, p=0.004). No association was observed between low ABI and stroke/transient ischaemic attack (p=0.91). In conclusion, low ABI is useful to predict MI and vascular death in NVAF patients and may independently facilitate cardiovascular risk assessment in NVAF patients.Note: The review process for this paper was fully handled by C. Weber, Editor in Chief.Listed in the Supplementary Online Appendix Material which is available online at www.thrombosis-online.com.

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Dufva, Melanie J., Dunbar Ivy, Kristen Campbell, Aimee Lam, Adam Rauff, Karel T. N. Breeman, Johannes M. Douwes, Rolf M. F. Berger, Vitaly Oleg Kheyfets, and Kendall Hunter. "Ventricular–vascular coupling is predictive of adverse clinical outcome in paediatric pulmonary arterial hypertension." Open Heart 8, no. 2 (September 2021): e001611. http://dx.doi.org/10.1136/openhrt-2021-001611.

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AimsVentricular–vascular coupling, the ratio between the right ventricle’s contractile state (Ees) and its afterload (Ea), may be a useful metric in the management of paediatric pulmonary arterial hypertension (PAH). In this study we assess the prognostic capacity of the ventricular–vascular coupling ratio (Ees/Ea) derived using right ventricular (RV) pressure alone in children with PAH.MethodsOne hundred and thirty paediatric patients who were diagnosed with PAH via right heart catheterisation were retrospectively reviewed over a 10-year period. Maximum RV isovolumic pressure and end-systolic pressure were estimated using two single-beat methods from Takeuchi et al (Ees/Ea_(Takeuchi)) and from Kind et al (Ees/Ea_(Kind)) and used with an estimate of end-systolic pressure to compute ventricular–vascular coupling from pressure alone. Patients were identified as either idiopathic/hereditary PAH or associated PAH (IPAH/HPAH and APAH, respectively). Haemodynamic data, clinical functional class and clinical worsening outcomes—separated into soft (mild) and hard (severe) event categories—were assessed. Adverse soft events included functional class worsening, syncopal event, hospitalisation due to a proportional hazard-related event and haemoptysis. Hard events included death, transplantation, initiation of prostanoid therapy and hospitalisation for atrial septostomy and Pott’s shunt. Cox proportional hazard modelling was used to assess whether Ees/Ea was predictive of time-to-event.ResultsIn patients with IPAH/HPAH, Ees/Ea_(Kind) and Ees/Ea_(Takeuchi) were both independently associated with time to hard event (p=0.003 and p=0.001, respectively) and when adjusted for indexed pulmonary vascular resistance (p=0.032 and p=0.013, respectively). Neither Ees/Ea_(Kind) nor Ees/Ea_(Takeuchi) were associated with time to soft event. In patients with APAH, neither Ees/Ea_(Kind) nor Ees/Ea_(Takeuchi) were associated with time to hard event or soft event.ConclusionsEes/Ea derived from pressure alone is a strong independent predictor of adverse outcome and could be a potential powerful prognostic tool for paediatric PAH.

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Salman, Nevriye, Hasan Yamalı, Bilge Olgun Keleş, Sezai Değirmenci, Jehat Kutlay, Yusuf Özer, and Sumru Şekerci. "Radial Artery Thrombosis Accompanying Acute Mesenteric Vascular Event: Case Report." Damar Cerrahi Dergisi 21, no. 2 (2012): 168–70. http://dx.doi.org/10.9739/uvcd.2012-30942.

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Stewart, L., T. Egnuni, F. Esteves, N. Yuldasheva, S. Wheatcroft, and G. Mavria. "DOCK4 genetic deletion impairs vascular recovery following an ischemic event." Journal of Molecular and Cellular Cardiology 120 (July 2018): 48–49. http://dx.doi.org/10.1016/j.yjmcc.2018.05.143.

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MECKLINGER, A., S. KONIG, N. RUFFING, W. REITH, M. MULLER, H. KAUL, G. BECKER, and E. ROLL. "Event-related potentials in people at risk for vascular dementia." International Journal of Psychophysiology 59, no. 1 (January 2006): 40–48. http://dx.doi.org/10.1016/j.ijpsycho.2005.06.009.

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Baruah, ManashP, Sanjay Kalra, and Bharti Kalra. "Primordial prevention of atherosclerotic vascular disease: Preventing the “pre-event”." Journal of Medical Nutrition and Nutraceuticals 4, no. 2 (2015): 61. http://dx.doi.org/10.4103/2278-1870.162169.

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Chakraborty, Debabrata, Tamashis Mukherjee, SankhaS Das, Pramanick Gobinda, and Sushan Mukhopadhayay. "Vessel wall calcification and vascular event: Are we concerned enough?" Journal of Family Medicine and Primary Care 11, no. 11 (2022): 7445. http://dx.doi.org/10.4103/jfmpc.jfmpc_1268_22.

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Patterson, Cam. "Gene Regulation and Arteriosclerosis: Are Developmental Programs Reactivated in Vascular Disease?" Thrombosis and Haemostasis 82, S 01 (1999): 27–31. http://dx.doi.org/10.1055/s-0037-1615549.

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SummaryThe molecular mechanisms regulating the development of vascular diseases such as atherosclerosis remain poorly understood at present. Similarities between genetic programs observed during the course of vascular disease with those observed during vascular development suggest that developmental processes are recapitulated in vascular disease. The earliest event in vascular development is the differentiation of endothelial cells from their mesodermally-derived hamangioblastic precursors. The receptor for vascular endothelial growth factor, KDR/flk-1, plays a critical role in these earliest stages of vascular development. During development and in the adult, expression of this receptor is restricted to vascular endothelial cells and their immediate precursors. We have therefore endeavored to determine the transcriptional events regulating KDR/flk-1 expression, with the hope of gaining insight into processes of vascular development that might also be important in vascular diseases of the adult.

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McCabe, John Joseph, Nicola Giannotti, Jonathan McNulty, Sean Collins, Sarah Coveney, Sean Murphy, Mary Barry, et al. "Cohort profile: BIOVASC-late, a prospective multicentred study of imaging and blood biomarkers of carotid plaque inflammation and risk of late vascular recurrence after non-severe stroke in Ireland." BMJ Open 10, no. 7 (July 2020): e038607. http://dx.doi.org/10.1136/bmjopen-2020-038607.

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PurposeInflammation is important in stroke. Anti-inflammatory therapy reduces vascular events in coronary patients. 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) identifies plaque inflammation-related metabolism. However, long-term prospective cohort studies investigating the association between carotid plaque inflammation, identified on 18F-FDG PET and the risk of recurrent vascular events, have not yet been undertaken in patients with stroke.ParticipantsThe Biomarkers Imaging Vulnerable Atherosclerosis in Symptomatic Carotid disease (BIOVASC) study and Dublin Carotid Atherosclerosis Study (DUCASS) are two prospective multicentred observational cohort studies, employing near-identical methodologies, which recruited 285 patients between 2008 and 2016 with non-severe stroke/transient ischaemic attack and ipsilateral carotid stenosis (50%–99%). Patients underwent coregistered carotid 18F-FDG PET/CT angiography and phlebotomy for measurement of inflammatory cytokines. Plaque 18F-FDG-uptake is expressed as maximum standardised uptake value (SUVmax) and tissue-to-background ratio. The BIOVASC-Late study is a follow-up study (median 7 years) of patients recruited to the DUCASS/BIOVASC cohorts.Findings to dateWe have reported that 18F-FDG-uptake in atherosclerotic plaques of patients with symptomatic carotid stenosis predicts early recurrent stroke, independent of luminal narrowing. The incorporation of 18F-FDG plaque uptake into a clinical prediction model also improves discrimination of early recurrent stroke, when compared with risk stratification by luminal stenosis alone. However, the relationship between 18F-FDG-uptake and late vascular events has not been investigated to date.Future plansThe primary aim of BIOVASC-Late is to investigate the association between SUVmax in symptomatic ‘culprit’ carotid plaque (as a marker of systemic inflammatory atherosclerosis) and the composite outcome of any late major vascular event (recurrent ischaemic stroke, coronary event or vascular death). Secondary aims are to investigate associations between: (1) SUVmax in symptomatic plaque, and individual vascular endpoints (2) SUVmax in asymptomatic contralateral carotid plaque and SUVmax in ipsilateral symptomatic plaque (3) SUVmax in asymptomatic carotid plaque and major vascular events (4) inflammatory cytokines and vascular events.

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Bar, Jair, Gal Markel, Teodor Gottfried, Ruth Percik, Raya Leibowitz-Amit, Raanan Berger, Talia Golan, et al. "Acute vascular events as a possibly related adverse event of immunotherapy: a single-institute retrospective study." European Journal of Cancer 120 (October 2019): 122–31. http://dx.doi.org/10.1016/j.ejca.2019.06.021.

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Papasotiriou, Sam D., Ryan Meader, and Eli Ehrenpreis. "S1039 Tofacitinib-Associated Adverse Vascular Events Reported to the Federal Adverse Event Reporting System (FAERS) Database." American Journal of Gastroenterology 117, no. 10S (October 2022): e753-e753. http://dx.doi.org/10.14309/01.ajg.0000860796.58123.24.

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Sikkink, Cornells JJM, Willem NJC van Asten, Martin A. van ‘t Hof, Herman van Langen, and J. Adam van der Vliet. "Decreased Ankle/Brachial Indices in Relation to Morbidity and Mortality in Patients with Peripheral Arterial Disease." Vascular Medicine 2, no. 3 (August 1997): 169–73. http://dx.doi.org/10.1177/1358863x9700200302.

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To determine the relationship between ankle/brachial indices (ABIs) and morbidity and mortality in patients with peripheral arterial disease (PAD), a historical cohort study was performed. A total of 154 patients who had undergone noninvasive arterial assessment of the lower extremities in 1989 and 1990 were selected for this purpose. Selection criteria were age >40 years at the time of investigation, a resting ABI <0.90 and the availability of an ABI after exercise or arterial occlusion. Mortality and vascular events were recorded after an average follow-up period of 6 years. A vascular event was defined as an intervention because of PAD, the occurrence of a nonfatal myocardial infarction or stroke, a transient ischaemic attack or a coronary artery bypass graft (CABG) or percutaneous transluminal coronary angioplasty (PTCA) procedure. During the period studied, 44 patients died and 111 patients suffered a vascular event. The relative risk for mortality was 3.1 per 0.50 decrease of the ABI at rest (95% confidence interval (CI) 1.1–8.7, p = 0.03) and 2.4 per 0.50 decrease of the ABI after exercise or arterial occlusion (95% CI 0.9–6.4, p = 0.08). The relative risk for mortality or the occurrence of a vascular event was 3.3 per 0.50 decrease of the resting ABI (95% CI 1.7–6.3, p<0.001) and 2.5 per 0.50 decrease of the ABI after exercise or occlusion (95% CI 1.5–4.4, p<0.001). After standardization, the prognostic power of the two types of ABIs was equivalent. The cumulative survival after 5 years was 63% for patients with resting ABIs <0.50, 71% for patients with ABIs 0.50–0.69 and 91% for those with ABIs of 0.70–0.89. There were obvious differences between the mean initial ABIs of patients who suffered a vascular event and/or died and those of survivors, who did not suffer an event. A relatively simple measurement like the determination of the resting ABI can give valuable information about the prognosis for vascular related morbidity and mortality. This can be of help in the approach of patients with PAD and assist in therapeutical decision making. Determination of the ABI after exercise or occlusion has no additional value for this purpose.

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Moneta, G. L. "Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study)." Yearbook of Vascular Surgery 2007 (January 2007): 262–63. http://dx.doi.org/10.1016/s0749-4041(08)70536-0.

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Suzuki, Norihiro, Motoki Sato, Kiyohiro Houkin, Yasuo Terayama, Shinichiro Uchiyama, Hiroyuki Daida, Hiroshi Shigematsu, et al. "One-Year Atherothrombotic Vascular Events Rates in Outpatients with Recent Non-Cardioembolic Ischemic Stroke: The EVEREST (Effective Vascular Event REduction after STroke) Registry." Journal of Stroke and Cerebrovascular Diseases 21, no. 4 (May 2012): 245–53. http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2012.01.010.

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Rothwell, PM, AJ Coull, LE Silver, JF Fairhead, MF Giles, CE Lovelock, JNE Redgrave, et al. "Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study)." Lancet 366, no. 9499 (November 2005): 1773–83. http://dx.doi.org/10.1016/s0140-6736(05)67702-1.

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Rothwell, P. N., A. J. Coull, and L. E. Silver. "Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study)." Journal of Vascular Surgery 43, no. 5 (May 2006): 1077. http://dx.doi.org/10.1016/j.jvs.2006.04.014.

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Rothwell, P. N., A. J. Coull, and L. E. Silver. "Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study)." Journal of Vascular Surgery 44, no. 1 (July 2006): 223. http://dx.doi.org/10.1016/j.jvs.2006.05.010.

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Meng, Xia, Yilong Wang, Xingquan Zhao, Chunxue Wang, Hao Li, Liping Liu, Yong Zhou, Jie Xu, and Yongjun Wang. "Validation of the Essen Stroke Risk Score and the Stroke Prognosis Instrument II in Chinese Patients." Stroke 42, no. 12 (December 2011): 3619–20. http://dx.doi.org/10.1161/strokeaha.111.624148.

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Background and Purpose— Little was known about the predictive accuracy of the Essen Stroke Risk Score and the Stroke Prognostic Instrument II in Chinese patients with stroke. Methods— We evaluated the predictive accuracy of both Essen Stroke Risk Score and Stroke Prognostic Instrument II scores for both recurrent stroke and combined vascular events using data from a prospective cohort of 11 384 patients with acute ischemic stroke and transient ischemic attack admitted to 132 urban hospitals throughout China. Results— The cumulative 1-year event rates were 16% (95% CI, 15%–16%) for recurrent stroke and 18% (95% CI, 18%–19%) for combined vascular events. Both event rates were significantly higher in patients with transient ischemic attack and increased significantly from lower to higher Essen Stroke Risk Score and Stroke Prognostic Instrument II categories. Essen Stroke Risk Score and Stroke Prognostic Instrument II had similar predictive accuracies for each study outcome. Conclusions— In Chinese patients with ischemic stroke or transient ischemic attack, both Essen Stroke Risk Score and Stroke Prognostic Instrument II scores are equally able to stratify the risk of recurrent stroke and combined vascular events.

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Ruggieri, Martino, Agata Polizzi, Chiara Battaglini, Stefania Tomarchio, Flavia Mendola, Domenico Restivo, Pietro Milone, et al. "Mixed Vascular Nevus Syndrome." Journal of Pediatric Neurology 16, no. 05 (August 20, 2018): 282–87. http://dx.doi.org/10.1055/s-0038-1667150.

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Mixed vascular nevus (or nevus vascularis mixtus) represents an admixture of cutaneous vascular malformations of the telangiectatic type and angiospastic spots of nevus anemicus. It can occur as a purely cutaneous trait or as a hallmark of a neurocutaneous phenotype, the so-called mixed vascular nevus syndrome. The latter is characterized by the combination of paired vascular twin nevi and brain abnormalities of the Dyke–Davidoff–Masson type, consisting of crossed cerebral/cerebellar hemiatrophy with hypoplasia of the ipsilateral cerebral vessels, and homolateral hypertrophy of the skull and sinuses (hyperpneumatization) with contralateral hemispheric hypertrophy. In other cases, the paired vascular twin nevi and brain malformations of the Dyke–Davidoff–Masson type occur in association with systemic abnormalities consisting of facial asymmetry, skeletal anomalies, and disorders of autoimmunity. In 2014, Happle proposed to name the syndrome with the eponym Ruggieri–Leech's syndrome after the first two authors who reported (independently) this phenotype in different patients.Pathogenically, this complex phenotype suggests that embryonic pairing and somatic recombination of recessive (didymotic) alleles controlling the balance between constriction (i.e., nevus anemicus) and dilatation (i.e., nevus telangiectaticus) of blood vessels could be the primary event causing the phenomena of cutaneous and brain vascular twin spotting and the paired phenomena of skull hyperpneumatization versus hypertrophy and brain megalencephaly/colpocephaly versus cortical dysplasia.

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Valent, Peter, Emir Hadzijusufovic, Gerit-Holger Schernthaner, Dominik Wolf, Delphine Rea, and Philipp le Coutre. "Vascular safety issues in CML patients treated with BCR/ABL1 kinase inhibitors." Blood 125, no. 6 (February 5, 2015): 901–6. http://dx.doi.org/10.1182/blood-2014-09-594432.

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Abstract Vascular safety is an emerging issue in patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors (TKIs). Whereas imatinib exhibits a well-documented and favorable long-term safety profile without obvious accumulation of vascular events, several types of vascular adverse events (VAEs) have been described in patients receiving second- or third-generation BCR/ABL1 TKIs. Such VAEs include pulmonary hypertension in patients treated with dasatinib, peripheral arterial occlusive disease and other arterial disorders in patients receiving nilotinib, and venous and arterial vascular occlusive events during ponatinib. Although each TKI interacts with a unique profile of molecular targets and has been associated with a unique pattern of adverse events, the mechanisms of drug-induced vasculopathy are not well understood. Here, recent data and concepts around VAEs in TKI-treated patients with CML are discussed, with special reference to potential mechanisms, event management, and strategies aimed at avoiding occurrence of such events in long-term treated patients.

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Bode, Robert H., Keith P. Lewis, Stuart W. Zarich, Eric T. Pierce, Mark Roberts, Glen J. Kowalchuk, Paul R. Satwicz, et al. "Cardiac Outcome after Peripheral Vascular Surgery." Anesthesiology 84, no. 1 (January 1, 1996): 3–13. http://dx.doi.org/10.1097/00000542-199601000-00002.

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Background Despite evidence that regional anesthesia may be associated with fewer perioperative complications than general anesthesia, most studies that have compared cardiac outcome after general or regional anesthesia alone have not shown major differences. This study examines the impact of anesthetic choice on cardiac outcome in patients undergoing peripheral vascular surgery who have a high likelihood of associated coronary artery disease. Methods Four hundred twenty-three patients, between 1988 and 1991, were randomly assigned to receive general (n = 138), epidural (n = 149), or spinal anesthesia (n = 136) for femoral to distal artery bypass surgery. All patients were monitored with radial artery and pulmonary artery catheters. Postoperatively, patients were in a monitored setting for 48-72 h and had daily electrocardiograms for 4-5 days and creatine phosphokinase/isoenzymes every 8 h x 3, then daily for 4 days. Cardiac outcomes recorded were myocardial infarction, angina, and congestive heart failure. Results Baseline clinical characteristics were not different between anesthetic groups. Overall, the patient population included 86% who were diabetic, 69% with hypertension, 36% with a history of a prior myocardial infarction, and 41% with a history of smoking. Cardiovascular morbidity and overall mortality were not significantly different between groups when analyzed by either intention to treat or type of anesthesia received. In the intention to treat analysis, incidences of cardiac event or death for general, spinal, and epidural groups were 16.7%, 21.3%, and 15.4%, respectively. The absolute risk difference observed between general and all regional anesthesia groups for cardiac event or death was -1.6% (95% confidence interval -9.2%, 6.1%) This reflected a nonsignificant trend for lower risk of postoperative events with general anesthesia. Conclusions The choice of anesthesia, when delivered as described, does not significantly influence cardiac morbidity and overall mortality in patients undergoing peripheral vascular surgery.

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Offer, Alison, Matthew Arnold, Robert Clarke, Derrick Bennett, Louise Bowman, Richard Bulbulia, Richard Haynes, et al. "Assessment of Vascular Event Prevention and Cognitive Function Among Older Adults With Preexisting Vascular Disease or Diabetes." JAMA Network Open 2, no. 3 (March 1, 2019): e190223. http://dx.doi.org/10.1001/jamanetworkopen.2019.0223.

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YAMASHITA, Atsushi, and Yujiro ASADA. "Prevention of cardiovascular event targeted vascular inflammation, and pathology of thrombosis." Japanese Journal of Thrombosis and Hemostasis 30, no. 6 (2019): 837–44. http://dx.doi.org/10.2491/jjsth.30.837.

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Xu, Jin, Songzhen Zhao, Haoshi Zhang, and Chongxun Zheng. "Decreased Delta Event-Related Synchronization in Patients with Early Vascular Dementia." Clinical EEG and Neuroscience 42, no. 1 (January 2011): 53–58. http://dx.doi.org/10.1177/155005941104200111.

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Hurley, Dan. "Large Dataset Spots Vascular Dysregulation as First Event in Alzheimerʼs Pathology." Neurology Today 16, no. 16 (August 2016): 17–18. http://dx.doi.org/10.1097/01.nt.0000494737.72062.41.

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Mahaffrey, Pamela. "A Personal Sentinel Event: The Nurse's Role in Preventing Vascular Complications." Journal of Vascular Nursing 33, no. 2 (June 2015): 84. http://dx.doi.org/10.1016/j.jvn.2015.05.018.

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Cleland, J. G. F. "Time for a proper study of aspirin after a vascular event?" BMJ 337, no. 19 1 (November 19, 2008): a2583. http://dx.doi.org/10.1136/bmj.a2583.

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Prescott, S. M., G. A. Zimmerman, T. M. McIntyre, and D. M. Stafforini. "Inflammation in the vascular wall as an early event in atherosclerosis." Diabetologia 40 (June 20, 1997): S111—S112. http://dx.doi.org/10.1007/s001250051420.

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STOLLER, MARSHALL L., MAXWELL V. MENG, HARRISON M. ABRAHAMS, and JOHN P. KANE. "The Primary Stone Event: A New Hypothesis Involving a Vascular Etiology." Journal of Urology 171, no. 5 (May 2004): 1920–24. http://dx.doi.org/10.1097/01.ju.0000120291.90839.49.

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Burbank, Scott A., Alexander R. Vaccaro, Maurice L. Goins, Clifford B. Tribus, and Ramon Manon-Espaillat. "Thoracic Paraparesis Following an Embolic Vascular Event During Lumbar Spinal Surgery." Journal of Spinal Disorders & Techniques 19, no. 1 (February 2006): 68–72. http://dx.doi.org/10.1097/01.bsd.0000168218.25602.e0.

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Wermer, M. J. H., P. Greebe, A. Algra, and G. J. E. Rinkel. "Long-term mortality and vascular event risk after aneurysmal subarachnoid haemorrhage." Journal of Neurology, Neurosurgery & Psychiatry 80, no. 12 (November 16, 2009): 1399–401. http://dx.doi.org/10.1136/jnnp.2008.157586.

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Journal articles on the topic 'Vascular event'

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