Dissertations / Theses on the topic 'Vascular endothelial growth factor'
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Krishnan, Jaya. "The role of vascular endothelial growth factor receptor 3, and its ligands vascular endothelial growth factor C and vascular endothelial growth factor D in tumour metastasis and haematopoeisis." Thesis, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.270576.
Full textPrahst, Claudia. "Neuropilin-vascular endothelial growth factor signaling in endothelial cells." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:25-opus-51230.
Full textBotelho, Francisco José dos Santos. "Vascular endothelial growth factor and prostate cancer." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/22291.
Full textBotelho, Francisco José dos Santos. "Vascular endothelial growth factor and prostate cancer." Dissertação, Faculdade de Medicina da Universidade do Porto, 2009. http://hdl.handle.net/10216/22291.
Full textJacobsen, Jan. "Vascular endothelial growth factor in renal cell carcinoma." Doctoral thesis, Umeå : Kirurgisk och perioperativ vetenskap, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-713.
Full textWang, Wenying. "Angiogenesis mediated by vascular endothelial growth factor (VEGF)." Thesis, University of Bristol, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.419061.
Full textRoberts, Selene Karen. "Signalling via vascular endothelial growth factor receptor complexes." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/29705.
Full textAase, Karin. "On vascular endothelial growth factor B and platelet-derived growth factor C : two members of the VEGF/PDGF family of growth factors /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-89428-14-5/.
Full textNg, Hoi-man, and 伍凱敏. "Regulation of vascular endothelial growth factor by ginsenoside RG1 inhuman endothelial cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2009. http://hub.hku.hk/bib/B43955915.
Full textFearnley, Gareth William. "Vascular endothelial growth factor A isoform-specific regulation of endothelial cell function." Thesis, University of Leeds, 2015. http://etheses.whiterose.ac.uk/10721/.
Full textGrad, Sibylle. "Regulation und Expression von vascular endothelial growth factor (VEGF) /." [S.l.] : [s.n.], 1999. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=13214.
Full textKnight, Emma Lavinia. "Signalling pathways downstream of vascular endothelial growth factor receptors." Thesis, University of Leicester, 2001. http://hdl.handle.net/2381/29663.
Full textGilmore, Louisa Jean. "Synthetic polymers for interaction with vascular endothelial growth factor." Thesis, University of Sheffield, 2010. http://etheses.whiterose.ac.uk/15109/.
Full textGrunstein, Jeremy. "The role of vascular endothelial growth factor in tumorigenesis /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2000. http://wwwlib.umi.com/cr/ucsd/fullcit?p9981953.
Full textBrockelsby, Jeremy Charles. "Pre-eclampsia : the role of vascular endothelial growth factor and its interaction with the vascular endothelium." Thesis, University of Nottingham, 2001. http://eprints.nottingham.ac.uk/11836/.
Full textWendt, Astrid [Verfasser]. "Korrelation von placental growth factor, vascular endothelial growth factor und soluble vascular endothelial growth factor receptor-1 im Serum mit Tumorstadien und Prognose des hepatozellulären Karzinoms / Astrid Wendt." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1212435109/34.
Full textNg, Hoi-man. "Regulation of vascular endothelial growth factor by ginsenoside RG1 in human endothelial cells." Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43955915.
Full textEriksson, Anna. "Molecular mechanisms of VEGF-family-mediated angiogenesis and vascular permeability /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-361-9/.
Full textClayton, Jason Allen Faber James E. "Role of vascular endothelial growth factor-A in collateral growth and development." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2008. http://dc.lib.unc.edu/u?/etd,2111.
Full textTitle from electronic title page (viewed Feb. 17, 2009). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Cell and Molecular Physiology." Discipline: Cell and Molecular Physiology; Department/School: Medicine.
Kumar, Harish. "The study of vascular endothelial growth factor in colorectal cancer." Thesis, University of Hull, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.411900.
Full textNúñez, Daniel A. "Experimental estimate of the diffusivity of Vascular Endothelial Growth Factor." Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/36721.
Full textIncludes bibliographical references (leaf 16).
The diffusivity of Vascular Endothelial Growth Factor (VEGF) is a number that is very important in determining the transport of VEGF. The transport of VEGF determines crucial processes such as angiogenesis and vasculogenesis. This study aimed at obtaining an estimate of the diffusivity of VEGF by using a simple system consisting of an insert with a collagen membrane placed within the well of a cell culture plate. A solution of VEGF was added to the insert, and the same solution without VEGF was added to the well surrounding the insert. The VEGF diffusion was monitored by taking samples in time of both the upstream and downstream baths, and analyzing the samples with an ELISA. Modeling the diffusion as one-dimensional, it was possible to estimate the diffusivity from the change in downstream concentration with time. The diffusivity was estimated to be around 5.55e⁻⁷ cm²sec.
by Daniel A. Nunez.
S.B.
Cudmore, Melissa Jane. "Novel functions of angiopoietins and vascular endothelial growth factor receptors." Thesis, University of Birmingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.434712.
Full textFoster, Rebecca Rachael. "The effects of vascular endothelial growth factor on podocyte biology." Thesis, University of Bristol, 2004. http://hdl.handle.net/1983/19d27014-82f5-417e-b92e-ef78b8b632a6.
Full textPlehutsa, O., A. Sydorchuk, P. Fomin, I. Sydorchuk, R. Sydorchuk, L. Sydorchuk, S. Levites, and A. Vinohradskyy. "Why targeting vascular endothelial growth factor is not sufficiently effective?" Thesis, «Targeted Therapies in Hepatologu» Worshop.- Abstract Book (Hannover, Germany, January 24-25, 2013). – P.29, 2013. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/7383.
Full textAthanassiades, Andrew. "The role of vascular endothelial growth factor and placenta growth factor in human trophoblast function." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0010/MQ28535.pdf.
Full textLiisanantti, M. (Marja). "Phosphatidylethanol in lipoproteins as a regulator of vascular endothelial growth factor in vascular wall cells." Doctoral thesis, University of Oulu, 2005. http://urn.fi/urn:isbn:9514278666.
Full textRubins, Leigh Ruth. "Recombinant antibody fragments to vascular associated targets of human tumours." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.369066.
Full textChen, Jing. "Mechanism of induction of vascular endothelial growth factor (vegf) in osteoarthritis." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/4616.
Full text"December 2006" The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Includes bibliographical references.
張毅 and Ngai Cheung. "Expression of vascular endothelial growth factor and its receptors in tumours." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31220587.
Full textMcElhinney, B. R. "Vascular endothelial growth factor and the ovarian response to iatrogenic stimulation." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.395369.
Full textCheung, Ngai. "Expression of vascular endothelial growth factor and its receptors in tumours /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20720981.
Full textLogan, Patrick. "Vascular endothelial growth factor-A expression and role in uveal melanoma." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=119440.
Full textIntroduction: Le mélanome uvéal (MU) est une tumeur intra-oculaire qui affecte 4 à 6 personnes par million aux États-Unis, dont 40% développeront des métastases du foie dans les cinq ans. Le facteur de croissance vasculaire endothélial A (VEGF-A) a été largement étudié sur le cancer en raison de l'exigence de la vascularisation des tumeurs supplémentaires. Le bevacizumab est un anticorps monoclonal humanisé qui se lie au VEGF-A et il est approuvé pour le traitement de diverses tumeurs malignes. Ici, nous avons étudié l'expression du VEGF-A dans trois lignées cellulaires du MU et les effets de l'inhibition du VEGF-A sur leurs capacités fonctionnelles. Nous avons également déterminé si VEGF-A positif d'expression ne peut prédire les métastases dans un modèle UM et chez les patients. Matériaux et méthodes: VEGF-A sécrétion a été évaluée dans trois lignées cellulaires du MU en utilisant ELISA en sandwich. Des tests de prolifération, la migration et l'invasion ont été réalisés avant et après l'administration de l'expression des cytokines et bevacizumab a été évaluée par ELISA. Une cytokine qui a été régulée à la hausse après le traitement bevacizumab (CCL3) a été renversée à l'aide de siRNA, et les tests fonctionnels ont été répétés en utilisant CCL3 siRNA et des traitements combinés. Des tumeurs de MU (n = 27) provenant d'un modèle animal et des tumeurs provenant de patients humains énucléés (n = 29) ont été immunocolorées pour le VEGF-A. Deux différents algorithmes de quantification immunomarquage mis en œuvre avec le logiciel ImageJ ont été utilisés pour compter automatiquement des cellules positives pour la région et une coloration positive. La régression logistique binaire a été effectuée pour déterminer si une coloration positive pouvait prédire les métastases. P <0,05 était considérée comme significative. Résultats: Les trois lignées cellulaires de MU ont produites et sécrétées du VEGF-A et ont exprimées du VEGF-R2. Le bevacizumab usurpé VEGF-A et réduit phosphorylée-VEGF-R2. La prolifération et la migration ont été réduites à la suite du traitement par le bevacizumab (p <0,05 pour une lignée cellulaire, et p <0,05 pour les deux lignées cellulaires, respectivement). Les deux CCL3 et MMP-9 étaient significativement augmentés à la hausse après le traitement par le bevacizumab dans toutes les lignées cellulaires (p <0,05). La prolifération a été réduite de façon significative dans les trois lignées cellulaires à la suite CCL3 siRNA et des traitements combinés (p <0,05). La migration a été significativement réduite dans les trois lignées cellulaires après le traitement combiné (p <0,05) et l'invasion a été considérablement réduite dans les deux lignées cellulaires suivantes siRNA (p <0,05). En général, la thérapie combinée était plus efficace que la monothérapie bevacizumab pour inhiber les capacités fonctionnelles du MU.Dans les deux lapins et les tissus humains, la présence du VEGF-A pourrait être utilisée pour prédire de façon significative des métastases (p> 0,05). Conclusions: La signalisation autocrine et paracrine du VEGF-A est abondante dans les lignées cellulaires du MU, mais l'inhibition du VEGF-A n'a que des effets modérés sur ses capacités fonctionnelles. Cette situation est attribuable à des effets compensatoires, y compris la régulation positive du CCL3. En outre, le VEGF-A coloration peuvent être utilisées pour identifier les patients prédisposés au développement métastatique. Le VEGF-A est une cytokine puissante qui peut jouer un rôle dans le développement et la progression du MU. Cependant, les effets compensatoires induits par le bevacizumab suggèrent que les thérapies doubles ou multiples peuvent être nécessaires pour traiter efficacement ce type de tumeur.
Anderl, Jeffrey Neil. "PLGA microsphere formulations for sustained local delivery of vascular endothelial growth factor : considerations for therapeutic angiogenesis of infarcted myocardium /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8110.
Full textRoche, Rebecca I. "Role of RNA Processing Factors in the Expression of Flt-1 and its Secreted Variant, sFlt-1." Diss., Virginia Tech, 2005. http://hdl.handle.net/10919/29632.
Full textPh. D.
Jehle, Mirjam. "Die Bedeutung des Vaskular-Endothelialen Wachstumsfaktor (VEGF) in der Heilung von Frakturen unter Weichteilschaden und Schock." [S.l. : s.n.], 2006. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-56057.
Full textLeucht, Frank Martin. "Untersuchungen zur VEGF und PlGF induzierten Chemotaxis multipotenter Stromazellen des Knochenmarks." [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:289-vts-64417.
Full text王, 英泰. "Hypoxia and vascular endothelial growth factor selectively upregulate angiopoietin-2 in bovine microvascular endothelial cells." Kyoto University, 2001. http://hdl.handle.net/2433/150200.
Full textPoon, Tung-ping Ronnie. "Prognostic significance of circulating vascular endothlial [sic] growth factor in patients with hepatocellular carcinoma." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36922249.
Full textYan, Qi. "Regulation of retinal endothelial cells and pericytes by VEGF, TGF-beta1, and SPARC /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/5686.
Full textWan, Wai-chong. "Identification and characterization of vascular endothelial growth factor (VEGF) in rat testis /." Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20668120.
Full text溫慧莊 and Wai-chong Wan. "Identification and characterization of vascular endothelial growth factor (VEGF) in rat testis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1998. http://hub.hku.hk/bib/B31221841.
Full textSipola, A. (Annina). "Effects of vascular endothelial growth factor (VEGF-A) and endostatin on bone." Doctoral thesis, University of Oulu, 2009. http://urn.fi/urn:isbn:9789514293184.
Full textAldridge, S. E. "Vascular endothelial growth factor and osteoclastogenesis : a role in metastasis to bone." Thesis, University of Newcastle upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405067.
Full textCaires, Kyle Cody. "Investigating the role of vascular endothelial growth factor in bovine testis development." Online access for everyone, 2007. http://www.dissertations.wsu.edu/Thesis/Spring2007/k_caires_050207.pdf.
Full textHunter, A. J. "Studies into the role of vascular endothelial growth factor in pre-eclampsia." Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368545.
Full textThickett, D. R. "The role of vascular endothelial growth factor in the pathogenesis of ARDS." Thesis, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393645.
Full textMcFee, Renee Marie. "The role of vascular endothelial growth factor isoforms in early follicle development." Thesis, Kansas State University, 2012. http://hdl.handle.net/2097/13525.
Full textDepartment of Animal Sciences and Industry
Timothy G. Rozell
Since vascularization of the theca layer increases as follicles progress in size through preantral and antral stages, the principal angiogenic factor, vascular endothelial growth factor A (VEGFA), may influence follicle growth via regulation of angiogenesis. However, VEGFA may also influence follicular development through nonangiogenic mechanisms since its expression has been localized to nonvascular follicles and cells. Alternative mRNA splicing of 8 exons from the VEGFA gene results in the formation of different VEGFA isoforms. Each isoform has unique properties and is identified by the number of amino acids within the mature protein. Proangiogenic isoforms are encoded by exon 8a while a sister set of isoforms with antiangiogenic properties are encoded by exon 8b. The antiangiogenic isoforms comprise the majority of VEGFA expressed in most tissues while expression of the proangiogenic VEGFA isoforms is upregulated in tissues undergoing active angiogenesis. The Vegfa angiogenic isoforms (Vegfa_120, Vegfa_164, and Vegfa_188) were detected in developing rat ovaries, and quantitative RT-PCR determined that Vegfa_120 and Vegfa_164 mRNA was more abundant after birth, while Vegfa_188 mRNA was highest at embryonic day 16. The antiangiogenic isoforms, Vegfa_165b and Vegfa_189b, were amplified and sequenced from rat ovaries and quantitative RT-PCR determined that Vegfa_165b mRNA was more abundant around embryonic day 18, but Vegfa_189b lacked a distinct pattern of abundance. VEGFA and its receptors were localized to pregranulosa and granulosa cells of all follicle stages and to theca cells of advanced-stage follicles. Antiangiogenic VEGFA isoforms were localized to pregranulosa and granulosa cells of all follicle stages and to theca cells of advanced-stage follicles. To determine the role of VEGFA in developing ovaries, postnatal day 3/4 rat ovaries were cultured with VEGFR-TKI, a tyrosine kinase inhibitor that blocks signaling through the VEGFA receptors, FLT1 and KDR. Ovaries treated with VEGFR-TKI had vascular development reduced by 94%. In addition, treated ovaries had more primordial follicles, fewer early primary, transitional, and secondary follicles, and greater total follicle numbers compared with control ovaries. This suggests that VEGFA promotes follicle recruitment and early follicular development. These effects may be dependent upon increased ovarian vascularization or they may be mediated by nonvascular mechanisms.
Peyromaure, Debord Broca Michaël. "Rôle du vascular endothelial growth factor (VEGF) dans le cancer prostatique localisé." Paris 5, 2006. http://www.theses.fr/2006PA05A001.
Full textNock, Sarah. "Prostate cancer expression of vascular endothelial growth factor splice forms in hypoxia." Kent State University Honors College / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ksuhonors1430770359.
Full textHeathcote, Helen Rachel. "The regulation of AMP-activated protein kinase by vascular endothelial growth factor." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7375/.
Full text