Journal articles on the topic 'Van Sommer'

Abstract. Assemblages of Middle Devonian (Givetian) phytoplankton from the Holy Cross Mountains include sphaeromorphs possessing blister-like ornamentation typical of the genus Tapajonites Sommer & van Boekel, 1963. Study of the sculptural elements under high magnification indicates the presence of patterns resembling impressions of pyrite crystals. It is suggested that ornamentation in Tapajonites, or at least in some sphaeromorphs assignable to that genus, is of a secondary nature.

Purpose The purpose of this study was to evaluate whether previously reported questionnaire-based differences in self-regulatory behaviors (Eggers, De Nil, & Van den Bergh, 2009, 2010) between children who stutter (CWS) and children who do not stutter (CWNS) would also be reflected in their underlying attentional networks. Method Participants consisted of 41 CWS (mean age = 6;09; years;months) and 41 CWNS (mean age = 6;09) ranging in age from 4;00 to 9;00. Participants were matched on age and gender. The efficiency of the attentional networks was assessed by using the computerized Attention Network Test (Fan, McCandliss, Sommer, Raz, & Posner, 2002). Results Primary results indicated that CWS had a significantly lower efficiency of the orienting network compared with CWNS, whereas no differences were found on the alerting or executive control network. Conclusion Current findings corroborate previously found differences in self-regulatory behavior and were taken to suggest a possible role for attentional processes in developmental stuttering.

Der vorliegende Text widmet sich der Bedeutung von Technologie-Demonstrationen in der Geschichte digitaler Medien. Diese werden als performative Praktiken betrachtet, in denen die Zukunft einer Technologie im Fokus steht. Unter Bezug auf einschlägige sozialwissenschaftliche Forschung diskutiert der Text die Rolle sogenannter imaginaries im Rahmen von Technologie-Demonstrationen. Diese theoretische Schwerpunktsetzung wird im Folgenden auf die Geschichte der Technologie-Demonstration im Bereich digitaler Medientechnologien bezogen. Aufbauend auf dem Gedanken, das speziell die Demonstration von User-Interfaces als Anker für die Mobilisierung von Imaginationen rund um die Zukunft digitaler Technologien dient, sichtet der Text drei Fallbeispiele: 1. die Präsentation des ‚oN-Line-System (NLS)‘ am 9. Dezember 1968 durch Douglas Engelbart; 2. die 100-tägige Demonstration des interaktiven Fernsehens Piazza virtuale während der documenta IX im Sommer 1992 durch die Medienkünstlergruppe Van Gogh-TV; 3. die Keynote-Präsentation des damaligen Apple CEO Steve Jobs anlässlich der Markteinführung des ersten iPhones am 9. Januar 2007. Anhand dieser teils kanonischen, teils vergessenen Beispiele zeigt sich die Bedeutung von Technologie-Demonstrationen für die soziale Vermittlung von neuen Technologien. Der Text schließt mit dem Argument, dass die Geschichte der Imagination digitaler Medien, wie sie in diesen Demonstrationen exemplarisch analysierbar wird, als ein integraler Bestandteil der Geschichte digitaler Medientechnologien generell zu betrachten ist.

The role of women in some prose works of C.M. van den Heever Re-reading the C.M. van den Heever “classics” Somer (1935) and Laat vrugte (1939) within the framework of Van den Heever criticism through the years, one becomes aware that central themes in his oeuvre are acted out by women. The beautiful young girl Linda in Somer embodies the sadness of the transcience of beauty and happiness. Through Ouma Willa, Betta and Johanna – three women from three generations in Laat vrugte – the theme of the endurance of the memory of love and passion beyond decay and death is expressed. A cursory examination of other and earlier works by Van den Heever – Op die plaas (1927), Langs die grootpad (1928), Kromburg (1937) and the short story “Leuens” (Lies) from Vuurvlieg en sterre (1934) – bears out the observation that women express core meanings in C.M. van den Heever’s prose works.

Hierdie opskrif laat min of meer reg geskied aan ’n belangrike baken in die ontwikkeling van die Afrikaanse prosa aan die einde van ’n dekade wat begin het met die meer tradisionele klem op die persoonlike, soos in die kortverhale van Hennie Aucamp en M.C. Botha. Nie dat dit by die private ache bly steek het nie! Sonder gevaar van teenspraak kan ’n mens hierdie roman ná die resepsie van Somer II en die ooreenkoms wat dit daarmee toon, as postmodernistiese teks benader. In die loop van hierdie bespreking sal om die beurt aan kernwoorde in die opskrif aandag gegee word.

Abstract This article interrogates three manuscript inventories for Anna of Denmark’s collection at the Tudor palace of Oatlands in Surrey, written at yearly intervals in 1616, 1617 and 1618. It explores the changing display of her paintings there in lavishly furnished settings and the positioning of a new portrait, Paul van Somer’s Anne of Denmark. Van Somer locates his subject in the hunting park at Oatlands with a representation, in the background, of an Inigo Jones gateway. This article explores Anna’s agency as a collector and patron. It proposes new readings for the interplay between portraiture, architecture, and the decorative and performing arts at the early Stuart court. Through a study of particular occasions at which they were seen by foreign ambassadors, it proposes a political currency for the queen’s collection and for van Somer’s portraits and Jones’s architecture, as integral components in the elaborate ‘performances’ of the court.

The long term effect of black hail netting (20% shading) on budding percentage, but fertility, cane mass, yield, bunch mass, berry mass and berry cracking as well as sugar concentration (total soluble solids), acid concentration (titratable acidity) and pH of the berry juice of table grapes (cultivars Pirobella, Bien Donne, Ronelle and Italia) was evaluated. Budding percentage and bud fertility were significantly reduced by hail netting. Reproductive growth in terms of yield and bunch mass seemed to be higher under hail netting compared to direct sunlight, while berry mass was not affected. Berry cracking tended to decrease under hail netting. Berry sugar concentration and pH decreased significantly under hail netting, while the acid concentration increased.

Syed Muhd Khairudin Aljunied, Rethinking Raffles; A study of Stamford Raffles’ discourse on religions amongst Malays. (Nathan Porath) Walter Angst, Wayang Indonesia; Die phantastische Welt des indonesischen Figurentheaters/The fantastic world of Indonesian puppet theatre. (Dick van der Meij) Adrienne Kappler and others, James Cook and the exploration of the Pacific. (H.J.M. Claesen) Aurel Croissant, Beate Martin and Sascha Kneip (eds), The politics of death; Political violence in Southeast Asia. (Freek Colombijn) Frank Dhont, Kevin W. Fogg and Mason C. Hoadley (eds), Towards an inclusive democratic Indonesian society; Bridging the gap between state uniformity and multicultural identity patterns. (Alexander Claver) Bronwen Douglas and Chris Ballard (eds), Foreign bodies; Oceania and the science of race, 1750-1940. (H.J.M. Claesen) Ricky Ganang, Jay Crain, and Vicki Pearson-Rounds, Kemaloh Lundayeh-English dictionary and bibliographic list of materials relating to the Lundayeh-Lun Bawang-Kelabit and related groups of Sarawak, Sabah, Brunei and East Kalimantan. (Michael Boutin) Jeffrey Hadler, Muslims and matriarchs; Cultural resilience in Indonesia through Jihad and Colonialism. (Franz von Benda-Beckmann) Uli Kozok, Kitab undang-undang Tanjung Tanah: Naskah Melayu yang tertua. (Arlo Griffiths) Alfonds van der Kraan, Murder and mayhem in seventeenth-century Cambodia; Anthony van Diemen vs. King Ramadhipati I. (Jeroen Rikkerink) Jean Michaud, ‘Incidental’ ethnographers; French Catholic missions on the Tonkin-Yunnan frontier, 1880-1930. (Nicholas Tapp) M.C. Ricklefs, Polarising Javanese society; Islamic and other visions (c. 1830-1930). (Matthew Isaac Cohen) Stuart Robson, Arjunawiwāha; The marriage of Arjuna of Mpu Kaṇwa. (Andrea Acri) László Székely and István Radnai, Dit altijd alleen zijn; Verhalen over het leven van planters en koelies in Deli (1914-1930). (Adrienne Zuiderweg) Patricia Tjiook-Liem (Giok Kiauw Nio Liem), De rechtspositie der Chinezen in Nederlands-Indië 1848-1942; Wetgevingsbeleid tussen beginsel en belang. (Mary Somers Heidhues) Zhou Daguan, A record of Cambodia: the land and its people. (Un Leang) REVIEW ESSAY Longitudinal studies in Javanese performing arts Benjamin Brinner, Music in Central Java; Experiencing music, expressing culture. Barbara Hatley, Javanese performances on an Indonesian stage; Contesting culture, embracing change. Felicia Hughes-Freeland, Embodied communities; Dance traditions and change in Java. (Matthew Isaac Cohen) REVIEW ESSAY Development and reform in Vietnam Stéphanie Balme and Mark Stephanie (eds), Vietnam’s new order; International perspectives on the state and reform in Vietnam. Sujian Guo, The political economy of Asian transition from communism. Ian Jeffries, Vietnam: a guide to economic and political developments. Pietro Masina, Vietnam’s development strategies. (Tran Quang Anh) KORTE SIGNALERINGEN Ulbe Bosma, Indiëgangers; Verhalen van Nederlanders die naar Indië trokken. Clara Brinkgreve, Met Indië verbonden; Een verhaal van vier generaties 1849-1949. Jack Botermans en Heleen Tichler, Het vergeten Indië; Stille getuigen van het dagelijks leven in het Indië van toen. Robin te Slaa en Edwin Klijn, De NSB; Ontstaan en opkomst van de Nationaal-Socialistische Beweging, 1931-1935. Mark Loderichs, Margaret Leidelmeijer, Johan van Langen en Jan Kompagnie, Verhalen in Documenten; Over het afscheid van Indië, 1940-1950. Frederik Erens en Adrienne Zuiderweg, Linggadjati, brug naar de toekomst; Soetan Sjahrir als een van de grondleggers van het vrije Indonesië. Peter Schumacher, met medewerking van Gerard de Boer, De zaak Aernout; Hardnekkige mythes rond een Indische moord ontrafeld. Cas Oorthuys, Een staat in wording; Fotoreportage van Cas Oorthuys over het Indonesië van 1947. René Kok, Erik Somers en Louis Zweers, Koloniale oorlog 1945-1949; Van Indië tot Indonesië. H.F. Veenendaal en J.P.W. Kelder, ZKH; Hoog spel aan het hof van Zijne Koninklijke Hoogheid; De geheime dagboeken van mr.dr.L.G. van Maasdijk. Ons Indië; 400 jaar Nederlandse sporen in Insulinde, de strijd om de onafhankelijkheid & 60 jaar Indonesië. (Harry A. Poeze)

Chimeric antigen receptor (CAR) T cells have demonstrated unprecedented efficacy in heavily pretreated relapsed and/or refractory multiple myeloma (MM) patients but may require further engineering to achieve their greatest potential. Enhancing cell expansion and persistence by providing cytokine support has been shown to improve the long-term antitumor activity of adoptively transferred CAR T cells in preclinical models. Combining CAR T cells with systemically-administered cytokines or cytokine mimetics can however result in toxicities and adverse events. Alternatively, cytokine signaling can be provided in a constitutive, CAR T cell-intrinsic fashion, by exogenous expression of a Constitutively Active Chimeric Cytokine Receptor (CACCR). CACCRs can be engineered by combining a membrane-tethered dimerization and JAK-binding domain derived from the thrombopoietin receptor (TpoR) fused to an intracellular signaling domain derived from a cytokine receptor. We investigated the impact of CACCR expression on the phenotype, functionality, persistence, and safety profile of allogeneic CAR T cells targeting BCMA to produce a second generation allogeneic BCMA "TurboCAR T™" candidate (ALLO-605). BCMA CAR T cells were generated from healthy donor T cells by lentiviral transduction with a CAR construct followed by genetic inactivation of the TRAC and CD52 loci using TALEN® gene editing. Allogeneic BCMA TurboCAR™ T cells, engineered for stoichiometric expression of the CAR and a CACCR via a self-cleaving peptide, were produced similarly. Constitutive expression of the CACCR during manufacturing had no negative effects on CAR T cell phenotype or yield and resulted in a product with over 60% stem cell memory/central memory T cells. In vitro, BCMA TurboCAR T™ cells showed enhanced cytokine secretion, polyfunctionality and improved serial killing activity. In a disseminated mouse model of multiple myeloma, BCMA TurboCAR T™ cells exhibited at least a 2-fold increase in peak expansion and enhanced survival and persistence compared to BCMA CAR T cells, resulting in prolonged antitumor responses and delaying relapses. Despite this enhanced persistence, we found that exposure to target cells was absolutely required for the expansion and long-term activity of BCMA TurboCAR T™ cells and no evidence of target- and cytokine-independent proliferation was observed. Since adoptive cell therapies have the potential to elicit toxicities in some patients, two alternative approaches to modulate BCMA TurboCAR T™ cell activity were investigated. First, we tested the ability of a CD20-based off-switch incorporated within the CAR to sensitize cells to rituximab and found effective depletion of BCMA TurboCAR T™ cells by complement or effector cells in vitro and in vivo in the presence of the antibody. In addition, we confirmed rapid inhibition of BCMA TurboCAR T™ cells by the protein tyrosine kinase inhibitor dasatinib, which has been shown to interfere with LCK activity. The prolonged persistence and antitumor responses seen in preclinical models along with a favorable safety profile of BCMA TurboCAR™ T cells support clinical investigation of ALLO-605 in relapsed or refractory multiple myeloma. Disclosures Sommer: Allogene Therapeutics, Inc.: Current Employment, Current equity holder in publicly-traded company. Lin:Allogene Therapeutics, Inc.: Current Employment, Current equity holder in publicly-traded company. Sutton:Allogene Therapeutics, Inc.: Current Employment, Current equity holder in publicly-traded company. Bentley:Allogene Therapeutics, Inc.: Current Employment, Current equity holder in publicly-traded company. Nguyen:Allogene Therapeutics, Inc.: Current Employment, Current equity holder in publicly-traded company. Yoon:Allogene Therapeutics, Inc.: Current Employment, Current equity holder in publicly-traded company. Au:Allogene Therapeutics, Inc.: Current Employment, Current equity holder in publicly-traded company. Vargas-Inchaustegui:Allogene Therapeutics, Inc.: Current Employment, Current equity holder in publicly-traded company. Cheng:Allogene Therapeutics, Inc.: Current Employment, Current equity holder in publicly-traded company. Van Blarcom:Allogene Therapeutics, Inc.: Current Employment, Current equity holder in publicly-traded company. Panowski:Allogene Therapeutics, Inc.: Current Employment, Current equity holder in publicly-traded company. Sasu:Allogene Therapeutics, Inc.: Current Employment, Current equity holder in publicly-traded company.

In this paper a numerical solution for the problem on suspended sediment concentration distribution in an alluvial channel flow has been computed on the base of PROFILE model proposed by L. C. Van Rijn for the case of uniform flow. Although, in the present case, mathematical model is quite simple, but it is exact enough to apply to Somme problems in practice. The aim of the paper is that the author would like to use the finite difference method for the same problem. The input data was used from experiment flume. The result showed that the concentration distribution fast decreased along the channel and concentration gradients became very small at the sections situated far enough from the upstream. Besides, a computing program me with the ability of graphic expression was established.

The autobiographical relationship between the concrete author and a character or narrator in a text has always been a problem in the study of literature. In this article it is illustrated how certain signals in the text may function as autobiographical indicators. These signals must direct the reader towards an autobiographical interpretation of a specific text, because this is often essential for an adequate reading of such a text. The methodological approach of this article is, though, that an autobiographical interpretation of a text should at all times be textually confirmed. Texts included in this study are Somer 11 and Suidpunt-jazz (André Letoit), Jonkmanskas and Die hemel help ons (Koos Prinsloo), Van stiltes en stemme (J.M. Gilfillan), Die droom (Uys Krige), Wynand se oorlog (Ria Jordaan), Sleep vir jou 'n stoel nader (André le Roux) and Klaaglied vir Koos (Lettie Viljoen).

The study of indirect translations (IT) into Ukrainian, viewed from a psycholinguistic perspective, will contribute to a better understanding of Soviet national policies and the post-Soviet linguistic and cultural condition. The paper pioneers a discussion of the strategies and types of IT via Russian in the domains of literature and religion. In many cases the corresponding Russian translation, which serves as a source text for the Ukrainian one, cannot be established with confidence, and the “sticking-out ears” of Russian mediation may only be monitored at the level of sentence structure, when Russian wording underlies the Ukrainian text and distorts its natural fluency. The discussion substantiates the strategies and singles out the types of IT, in particular, (1) Soviet lower-quality retranslations of the recent, and mostly high-quality, translations of literary classics, which deliberately imitated lexical, grammatical, and stylistic patterns of the Russian language (became massive in scope in the mid1930s); (2) the translation-from-crib type, or translations via the Russian interlinear version, which have been especially common in poetry after WWII, from the languages of the USSR nationalities and the socialist camp countries; (3) overt relayed translations, based on the published and intended for the audience Russian translations that can be clearly defined as the source texts for the IT into Ukrainian; this phenomenon may be best illustrated with Patriarch Filaret Version of the Holy Scripture, translated from the Russian Synodal Bible (the translation started in the early 1970s); and, finally, (4) later Soviet (from the mid1950s) and post-Soviet (during Independence period) hidden relayed translations of literary works, which have been declared as direct ones but in fact appeared in print shortly after the publication of the respective works in Russian translation and mirrored Russian lexical and stylistic patterns. References Белецкий, А. Переводная литература на Украине // Красное слово. 1929. № 2. С. 87-96. Цит за вид.: Кальниченко О. А., Полякова Ю. Ю. Українська перекладознавча думка 1920-х – початку 1930-х років: Хрестоматія вибраних праць з перекладознавства до курсу «Історія перекладу» / Укладачі Леонід Чернований і Вячеслав Карабан. Вінниця: Нова Книга, 2011. С. 376-391. Бурґгардт, Осв. Большевицька спадщина // Вістник. 1939. № 1, Кн. 2. С. 94-99. Dollerup, C. (2014). Relay in Translation. Cross-linguistic Interaction: Translation, Contrastive and Cognitive Studies. Liber Amicorum in Honour of Prof. Bistra Alexieva published on the occasion of her eightieth birthday, Diana Yankova, (Ed.). (pp. 21-32). St. Kliminent Ohridski University Press. Retrieved from https://cms13659.hstatic.dk/upload_dir/docs/Publications/232-Relay-in-translation-(1).pdf Dong, Xi (2012). A Probe into Translation Strategies from Relevance Perspective—Direct Translation and Indirect Translation. Canadian Social Science, 8(6), 39-44. Retrieved from http://www.cscanada.org/index.php/css/article/viewFile/j.css.1923669720120806.9252/3281 Дзера, О.. Історія українських перекладів Святого Письма // Іноземна філологія. 2014. Вип. 127, Ч. 2. С. 214–222. Філарет, Патріарх Київський та всієї Руси-України, Василь Шкляр, Микола Вересень, В’ячеслав Кириленко. Розмова В’ячеслава Кириленка із Патріархом Київським та всієї Руси-України Філаретом. Віра. У кн.: Три розмови про Україну. Упорядник та радактор В. Кириленко. Х.: Книжковий Клуб «Клуб Сімейного Дозвілля», 2018. С. 9-92. Flynn, P. (2013). Author and Translator. In Yves Gambier, Luc van Doorslaer (Eds.), Handbook of Translation Studies, 4, (pp. 12-19). Amsterdam / Philadelphia: John Benjamins Publishing Company. Gutt, E.-A. (1990). A theoretical account of translation – without a translation theory. Retrieved from http://cogprints.org/2597/1/THEORACC.htm Коломієць Л. В. Український художній переклад та перекладачі 1920-30-х років: матеріали до курсу «Історія перекладу». Вінниця: «Нова книга», 2015. Іларіон, митр. Біблія – найперше джерело для вивчення своєї літературної мови / Митр. Іларіон // Віра і культура. 1958. Ч. 6 (66). С. 13–17. Іларіон, митр. Біблія, або Книги Святого Письма Старого и Нового Заповіту. Із мови давньоєврейської й грецької на українську дослівно наново перекладена. United Bible Societies, 1962. Jinyu L. (2012). Habitus of Translators as Socialized Individuals: Bourdieu’s Account. Theory and Practice in Language Studies, 2(6), 1168-1173. Leighton, L. (1991). Two Worlds, One Art. Literary Translation in Russia and America. DeKalb, Ill.: Northwestern Illinois UP. Лукаш М. Прогресивна західноєвропейська література в перекладах на українську мову // Протей [редкол. О. Кальниченко (голова) та ін.]. Вип. 2. X.: Вид-во НУА, 2009. С. 560–605. Майфет, Г. [Рецензія] // Червоний шлях. 1930. № 2. С. 252-258. Рец. на кн.: Боккаччо Дж. Декамерон / пер. Л. Пахаревського та П. Майорського; ред. С. Родзевича та П. Мохора; вступ. ст. В. Державіна. [Харків]; ДВУ, 1929. Ч. 1. XXXI, 408 с.; Ч. 2. Цит за вид.: Кальниченко О. А., Полякова Ю. Ю. Українська перекладознавча думка 1920-х – початку 1930-х років: Хрестоматія вибраних праць з перекладознавства до курсу «Історія перекладу» / Укладачі Леонід Чернований і Вячеслав Карабан. Вінниця: Нова Книга, 2011. С. 344-356. Munday, J. (2010). Introducing Translation Studies: Theories and Applications. 2nd Ed. London & New York: Routledge. Pauly, M. D. (2014). Breaking the Tongue: Language, Education, and Power in Soviet Ukraine. Toronto Buffalo London: University of Toronto Press. Pieta, H. & Rosa, A. A. (2013). Panel 7: Indirect translation: exploratory panel on the state-of-the-art and future research avenues. 7th EST Congress – Germersheim, 29 August – 1 September 2013. Retrieved from http://www.fb06.uni-mainz.de/est/51.php Плющ, Б. O. Прямий та неопрямий переклад української художньої прози англійською, німецькою, іспанською та російською мовами. Дис. …канд. філол. наук., Київ: КНУ імені Тараса Шевченка, 2016. Ringmar, M. (2012). Relay translation. In Yves Gambier, Luc van Doorslaer (Eds.), Handbook of Translation Studies, 4 (pp. 141-144). Amsterdam / Philadelphia: John Benjamins Publishing Company. Simeoni, D. (1998). The pivotal status of the translator’s habitus. Target, 10(1), 1-39. Солодовнікова, М. І. Відтворення стилістичних особливостей роману Марка Твена «Пригоди Тома Сойера» в українських перекладах: квантитативний аспект // Перспективи розвитку філологічних наук: Матеріали ІІІ Міжнародної науково-практичної конференції (Хмельницький, 24-25 березня). Херсон: вид-во «Гельветика», 2017. С. 99-103. Sommer, D, ed. (2006). Cultural Agency in the Americas. [Synopsis]. Durham, NC: Duke University Press. Špirk, J. (2014). Censorship, Indirect Translations and Non-translation: The (Fateful) Adventures of Czech Literature in 20th-century Portugal. Newcastle upon Tyne: Cambridge Scholars Publishing. Venuti, L. (2001). Strategies of Translation. In M. Baker (ed.). Routledge Encyclopedia of Translation Studies, (pp. 240-244). London & New York: Routledge. References (translated and transliterated) Beletskii, A. (1929). Perevodnaia literatura na Ukraine [Translated literature in Ukraine]. Krasnoe Slovo [Red Word], 2, 87-96. Reprint in: Kalnychenko, O. A. and Poliakova, Yu. (2011). In Leonid Chernovatyi and Viacheslav Karaban (Eds.). Ukraiins’ka perekladoznavcha dumka 1920-kh – pochatku 1930-kh rokiv: Khrestomatiia vybranykh prats z perekladosnavstva do kursu “Istoriia perekladu” [Ukrainian translation studies of the 1920s – early 1930s: A textbook of selected works in translation studies for a course on the “History of Translation”]. (pp. 376-391). Vinnytsia: Nova Knyha, Burghardt, O. (1939). Bolshevytska spadschyna [The Bolsheviks’ heritage]. Vistnyk [The Herald], Vol. 1, Book 2, 94-99. Dollerup, C. (2014). Relay in Translation. Cross-linguistic Interaction: Translation, Contrastive and Cognitive Studies. Liber Amicorum in Honour of Prof. Bistra Alexieva published on the occasion of her eightieth birthday, Diana Yankova, (Ed.). (pp. 21-32). St. Kliminent Ohridski University Press. Retrieved from https://cms13659.hstatic.dk/upload_dir/docs/Publications/232-Relay-in-translation-(1).pdf Dong, Xi (2012). A Probe into Translation Strategies from Relevance Perspective—Direct Translation and Indirect Translation. Canadian Social Science, 8(6), 39-44. Retrieved from http://www.cscanada.org/index.php/css/article/viewFile/j.css.1923669720120806.9252/3281 Dzera, O. (2014). Istoriia ukraiinskykh perekladiv Sviatoho Pysma [History of Ukrainian translations of the Holy Scripture]. Inozemna Filologiia, 127, Part 2, 214-222. Filaret, Patriarch of Kyiv and all Rus-Ukraine et al. (2018). Rozmova Viacheslava Kyrylenka iz Patriarkhom Kyivskym ta vsiiei Rusy-Ukrainy Filaretom. Vira [A Conversation of Viacheslav Kyrylenko with Patriarch of Kyiv and all Rus-Ukraine Filaret. Faith]. In: Try rozmovy pro Ukrainu [Three Conversations about Ukraine], compiled and edited by V. Kyrylenko. Kharkiv: Family Leisure Club, 9-92. Flynn, P. (2013). Author and Translator. In Yves Gambier, Luc van Doorslaer (Eds.), Handbook of Translation Studies, 4, (pp. 12-19). Amsterdam / Philadelphia: John Benjamins Publishing Company. Gutt, E.-A. (1990). A theoretical account of translation – without a translation theory. Retrieved from http://cogprints.org/2597/1/THEORACC.htm Kolomiyets, L. (2015). Ukraiinskyi khudozhniy pereklad ta perekladachi 1920-30-kh rokiv: Materialy do kursu “Istoriia perekladu” [Ukrainian Literary Translation and Translators in the 1920s-30s: “History of translation” course materials]. Vinnytsia: Nova Knyha. Ilarion, Metropolitan (1958). Bibliia – naipershe dzherelo dlia vyvchennia svoiei literaturnoi movy [The Bible is the first source for studying our literary language]. Vira i kultura [Faith and Culture], No. 6 (66), 13–17. Ilarion, Metropolitan. 1962. Bibliia abo Knyhy Sviatoho Pusma Staroho i Novoho Zapovitu. Iz movy davnioievreiskoi i hretskoi na ukrainsku doslivno nanovo perekladena. Commissioned by United Bible Societies. Jinyu L. (2012). Habitus of Translators as Socialized Individuals: Bourdieu’s Account. Theory and Practice in Language Studies, 2(6), 1168-1173. Leighton, L. (1991). Two Worlds, One Art. Literary Translation in Russia and America. DeKalb, Ill.: Northwestern Illinois UP. Lukash, M. (2009). Prohresyvna zakhidnoievropeiska literatura v perekladakh na ukraiinsku movu [Progressive West European Literature in Ukrainian]. Protei. Vol. 2. Edited by O. Kalnychenko. Kharkiv: Vydavnytstvo NUA, 560-605. Maifet, H. (1930). [Review]. Chervonyi Shliakh [Red Path], 2, 252-258. Review of the book: Boccaccio G. Decameron. Tr. by L. Pakharevskyi and P. Maiorskyi; S. Rodzevych and P. Mokhor (Eds.).; introduction by V. Derzhavyn. Kharkiv: DVU, 1929. Part 1. XXXI; Part 2. Reprint in: Kalnychenko, O. and Poliakova, Yu. (2011). In Leonid Chernovatyi and Viacheslav Karaban (Eds). Ukraiins’ka perekladoznavcha dumka 1920-kh – pochatku 1930-kh rokiv: Khrestomatiia vybranykh prats z perekladosnavstva do kursu “Istoriia perekladu” [Ukrainian translation studies of the 1920s – early 1930s: A textbook of selected works in translation studies for a course on the “History of Translation”]. (pp. 344-356). Vinnytsia: Nova Knyha. Munday, J. (2010). Introducing Translation Studies: Theories and applications. 2nd Ed. London & New York: Routledge. Pauly, M. D. (2014). Breaking the Tongue: Language, Education, and Power in Soviet Ukraine. Toronto Buffalo London: University of Toronto Press. Pieta, H. & Rosa, A. A. (2013). Panel 7: Indirect translation: exploratory panel on the state-of-the-art and future research avenues. 7th EST Congress – Germersheim, 29 August – 1 September 2013. Retrieved from http://www.fb06.uni-mainz.de/est/51.php Pliushch, B. (2016). Direct and Indirect Translations of Ukrainian Literary Prose into English, German, Spanish and Russian. PhD thesis. Manuscript copyright. Kyiv: Taras Shevchenko National University of Kyiv. Ringmar, M. (2012). Relay translation. In Yves Gambier, Luc van Doorslaer (Eds.), Handbook of Translation Studies, 4 (pp. 141-144). Amsterdam / Philadelphia: John Benjamins Publishing Company. Simeoni, D. (1998). The pivotal status of the translator’s habitus. Target, 10(1), 1-39. Solodovnikova. M. I. (2017) Vidtvorennia stylistychnykh osoblyvostei romanu Marka Tvena “Pryhody Toma Soiera” v ukrainskykh perekladakh: kvantytatyvnyi aspekt. Perspektyvy rozvytku filolohichnykh nauk: Book of abstracts of III International Scientific Conference (Khmelnytskyi, 24-25 March). Kherson: Helvetyka Publishing House. (99-103). Sommer, D., Ed. (2006). Cultural Agency in the Americas. [Synopsis]. Durham, NC: Duke University Press. Špirk, J. (2014). Censorship, Indirect Translations and Non-translation: The (Fateful) Adventures of Czech Literature in 20th-century Portugal. Newcastle upon Tyne: Cambridge Scholars Publishing. Venuti, L. (2001). Strategies of Translation. In Routledge Encyclopedia of Translation Studies, (pp. 240-244). M. Baker (ed.). London & New York: Routledge.

-Monika Arnez, Keith Foulcher ,Clearing a space; Postcolonial readings of modern Indonesian literature. Leiden: KITlV Press, 2002, 381 pp. [Verhandelingen 202.], Tony Day (eds) -R.H. Barnes, Thomas Reuter, The house of our ancestors; Precedence and dualism in highland Balinese society. Leiden: KITLV Press, 2002, viii + 359 pp. [Verhandelingen 198.] -Freek Colombijn, Adriaan Bedner, Administrative courts in Indonesia; A socio-legal study. The Hague: Kluwer law international, 2001, xiv + 300 pp. [The London-Leiden series on law, administration and development 6.] -Manuelle Franck, Peter J.M. Nas, The Indonesian town revisited. Singapore: Institute of Southeast Asian studies, 2002, vi + 428 pp. [Southeast Asian dynamics.] -Hans Hägerdal, Ernst van Veen, Decay or defeat? An inquiry into the Portuguese decline in Asia 1580-1645. Leiden: Research school of Asian, African and Amerindian studies, 2000, iv + 306 pp. [Studies on overseas history, 1.] -Rens Heringa, Genevieve Duggan, Ikats of Savu; Women weaving history in eastern Indonesia. Bangkok: White Lotus, 2001, xiii + 151 pp. [Studies in the material culture of Southeast Asia 1.] -August den Hollander, Kees Groeneboer, Een vorst onder de taalgeleerden; Herman Nuebronner van der Tuuk; Afgevaardigde voor Indië van het Nederlandsch Bijbelgenootschap 1847-1873; Een bronnenpublicatie. Leiden: KITlV Uitgeverij, 2002, 965 pp. -Edwin Jurriëns, William Atkins, The politics of Southeast Asia's new media. London: RoutledgeCurzon, 2002, xii + 235 pp. -Victor T. King, Poline Bala, Changing border and identities in the Kelabit highlands; Anthropological reflections on growing up in a Kelabit village near an international frontier. Kota Samarahan, Sarawak: Unit Penerbitan Universiti Malayasia Sarawak, Institute of East Asian studies, 2002, xiv + 142 pp. [Dayak studies contemporary society series 1.] -Han Knapen, Bernard Sellato, Innermost Borneo; Studies in Dayak cultures. Singapore: Singapore University Press, 2002, 221 pp. -Michael Laffan, Rudolf Mrázek, Engineers of happy land; Technology and nationalism in a colony. Princeton, NJ: Princeton University Press, 2002, xvii + 311 pp. [Princeton studies in culture/power/history 15.] -Johan Meuleman, Michael Francis Laffan, Islamic nationhood and colonial Indonesia; The umma below the winds. London: RoutledgeCurzon, 2003, xvi + 294 pp. [SOAS/RoutledgeCurzon studies on the Middle East 1.] -Rudolf Mrázek, Heidi Dahles, Tourism, heritage and national culture in Java; Dilemmas of a local community. Leiden: International Institute for Asian studies/Curzon, 2001, xvii + 257 pp. -Anke Niehof, Kathleen M. Adams ,Home and hegemony; Domestic service and identity politics in South and Southeast Asia. Ann Arbor: University of Michigan Press, 2000, 307 pp., Sara Dickey (eds) -Robert van Niel, H.W. van den Doel, Afscheid van Indië; De val van het Nederlandse imperium in Azië. Amsterdam: Prometheus, 2001, 475 pp. -Anton Ploeg, Bruce M. Knauft, Exchanging the past; A rainforest world of before and after. Chicago: University of Chicago Press, 2002, x + 303 pp. -Harry A. Poeze, Nicolaas George Bernhard Gouka, De petitie-Soetardjo; Een Hollandse misser in Indië? (1936-1938). Amsterdam: Rozenberg, 303 pp. -Harry A. Poeze, Jaap Harskamp (compiler), The Indonesian question; The Dutch/Western response to the struggle for independence in Indonesia 1945-1950; an annotated catalogue of primary materials held in the British Library. London; The British Library, 2001, xx + 210 pp. -Elisabeth Schröder-Butterfill, Jan Breman ,Good times and bad times in rural Java; Case study of socio-economic dynamics in two villages towards the end of the twentieth century. Leiden: KITLV Press, 2002, xii + 330 pp. [Verhandelingen 195.], Gunawan Wiradi (eds) -Mariëtte van Selm, L.P. van Putten, Ambitie en onvermogen; Gouverneurs-generaal van Nederlands-Indië 1610-1796. Rotterdam: ILCO-productions, 2002, 192 pp. -Heather Sutherland, William Cummings, Making blood white; Historical transformations in early modern Makassar. Honolulu: University of Hawai'i Press, 2002, xiii + 257 pp. -Gerard Termorshuizen, Olf Praamstra, Een feministe in de tropen; De Indische jaren van Mina Kruseman. Leiden: KITlV Uitgeverij, 2003, 111 p. [Boekerij 'Oost en West'.] -Jaap Timmer, Dirk A.M. Smidt, Kamoro art; Tradition and innovation in a New Guinea culture; With an essay on Kamoro life and ritual by Jan Pouwer. Amsterdam: KIT Publishers/Rijksmuseum voor Volkenkunde, 2003, 157 pp. -Sikko Visscher, Amy L. Freedman, Political participation and ethnic minorities; Chinese overseas in Malaysia, Indonesia and the United States. London: Routledge, 2000, xvi + 231 pp. -Reed L. Wadley, Mary Somers Heidhues, Golddiggers, farmers, and traders in the 'Chinese districts' of West Kalimantan, Indonesia. Ithaca, NY: Southeast Asia program, Cornell University, 2003, 309 pp. -Edwin Wieringa, Jan Parmentier ,Peper, Plancius en porselein; De reis van het schip Swarte Leeuw naar Atjeh en Bantam, 1601-1603. Zutphen: Walburg Pers, 2003, 237 pp. [Werken van de Linschoten-Vereeniging 101.], Karel Davids, John Everaert (eds) -Edwin Wieringa, Leonard Blussé ,Kennis en Compagnie; De Verenigde Oost-Indische Compagnie en de moderne wetenschap. Amsterdam: Balans, 2002, 191 pp., Ilonka Ooms (eds) -Edwin Wieringa, Femme S. Gaastra, De geschiedenis van de VOC. Zutphen; Wal_burg Pers, 2002, 192 pp.

Let \(G\) be a simple graph with vertex set \(V=\{v_1,v_2,\ldots,v_n \}\), and let \(d_i\) be the degree of the vertex \(v_i\). The Sombor matrix of \(G\) is the square matrix \(\mathbf A_{SO}\) of order \(n\), whose \((i,j)\)-element is \(\sqrt{d_i^2+d_j^2}\) if \(v_i\) and \(v_j\) are adjacent, and zero otherwise. We study the characteristic polynomial, spectrum, and energy of \(\mathbf A_{SO}\). A few results for the coefficients of the characteristic polynomial, and bounds for the energy of \(\mathbf A_{SO}\) are established.

Abstract Autologous chimeric antigen receptor (CAR) T cells targeting B-Cell Maturation Antigen (BCMA) have demonstrated promising clinical activity, inducing durable responses in patients with relapsed/refractory multiple myeloma (MM). Development of autologous CAR T therapies is however limited by logistical challenges and the time required for manufacturing, which has to be done for each patient. In addition, manufacturing may not be feasible in some patients. An allogeneic approach that utilizes engineered cells from a healthy donor could potentially expand patient access to these therapies by providing a readily available off-the-shelf product. We have previously described the screening of a library of single chain variable fragments (scFvs) with high affinity to human BCMA and the identification of candidate BCMA CARs with potent antitumor activity. Here we sought to further characterize ALLO-715, our lead allogeneic BCMA CAR T cell product, for its specificity to human BCMA, antitumor efficacy in vitro using a long-term killing assay and in xenograft mouse models with physiologic levels of human IL-7 and IL-15, and suitability for scale-up manufacturing. Allogeneic ALLO-715 CAR T cells were generated by lentiviral transduction with a second generation CAR construct incorporating a novel scFv derived from a fully-human antibody with high affinity to BCMA (KD value ~ 5 nM, determined at 37°C) and featuring a rituximab-driven off-switch. Transduced T cells were then transfected with mRNAs encoding Transcription Activator-Like Effector Nucleases (TALEN®) designed to specifically disrupt the T cell receptor alpha chain and CD52 loci. These modifications result in a cell product with a lower risk of TCR-mediated graft-versus-host disease and resistance to the CD52 antibody alemtuzumab, a lymphodepleting agent. BCMA CAR T cells exhibited robust cell expansion, with low levels of tonic signaling that resulted in minimal differentiation (> 50% Tscm/Tcm phenotype). In in vitro assays, ALLO-715 CAR T cells displayed potent cytotoxic activity when co-cultured with the target cell lines MM.1S, Molp-8, and BCMA-REH but negligible cytotoxicity against BCMA-negative REH cells. The high proliferative potential indicated by the high frequency of memory T cells was validated in long-term killing assays, where ALLO-715 CAR T cells showed substantial expansion in the presence of MM.1S cells with no evidence of exhaustion or diminished cytolytic activity after seven days of continuous exposure to target. The potency of ALLO-715 CAR T cells was unaffected by high concentrations of soluble BCMA (>10 ug/mL), which has been shown previously to interfere with the activity of some BCMA-specific CARs. In MM xenograft mouse models, ALLO-715 CAR T cells were highly efficacious at single dose. High serum IL-15 levels have been associated with CAR T cell expansion in clinical trials. To evaluate the impact of homeostatic cytokines on CAR T cell survival and antitumor activity in our xenograft models, mice were administered adeno-associated viruses (AAV) for the expression of human IL-7 and IL-15. In the presence of physiological concentrations of these cytokines, enhanced BCMA CAR T cell expansion and anti-tumor activity were observed. To assess potential off-target interactions of ALLO-715 CAR, tissue cross-reactivity studies were carried out on standard human tissue panels using a scFv-human IgG fusion protein. Consistent with the limited expression pattern of BCMA, reactivity was seen on scattered cells in lymphoid tissues such as tonsil and abundantly on BCMA-expressing cell lines, but no appreciable staining was detected in other tissues. We examined BCMA CAR T cells manufactured following a proprietary GMP-like clinical scale process and found that cell expansion and viability, T cell phenotype and in vivo antitumor efficacy were preserved. These results demonstrate the potential of ALLO-715 as a novel allogeneic BCMA CAR T therapy for the treatment of relapsed/refractory MM and other BCMA-positive malignancies. Disclosures Sommer: Allogene Therapeutics: Employment, Equity Ownership, Patents & Royalties. Boldajipour:Pfizer Inc.: Employment, Patents & Royalties. Valton:Cellectis.Inc: Employment, Equity Ownership, Patents & Royalties. Galetto:Cellectis SA: Employment, Equity Ownership, Patents & Royalties. Bentley:Allogene Therapeutics: Employment, Equity Ownership. Sutton:Allogene Therapeutics: Employment, Equity Ownership. Ni:Allogene Therapeutics: Employment, Equity Ownership. Leonard:Allogene Therapeutics: Employment, Equity Ownership. Van Blarcom:Allogene Therapeutics: Employment, Equity Ownership. Smith:Cellectis. Inc: Employment, Patents & Royalties. Chaparro-Riggers:Pfizer Inc.: Employment, Patents & Royalties. Sasu:Allogene Therapeutics: Employment, Equity Ownership, Patents & Royalties.

Au Québec et ailleurs, les gouvernements investissent des sommes sans précédent afin de construire les écoles de demain selon des orientations architecturales qui se fondent sur des espaces ouverts, flexibles, modulables et laissant entrer la lumière naturelle. Dans ce courant, plusieurs enseignants se tournent actuellement vers le modèle des « classes à aménagement flexible » (flexible seating) afin de faire face aux besoins complexes et hétérogènes des élèves, et de favoriser un climat de classe propice aux apprentissages (McKeown, Stringer et Cairns, 2015; van den Berg et Cillessen, 2015). Cependant, rares sont les études qui abordent les pratiques enseignantes. De plus, les observations rapportées ne se concentrent pas nécessairement sur les élèves ou l'enseignant ; dans leur relation à l’espace et dans leurs interactions. Ceci constitue une sérieuse limite des études existantes et disponibles. Ce numéro thématique propose six articles qui posent les jalons des connaissances croisées entre la didactique, la pédagogie, la psychologie et l’aménagement physique de la classe. C’est avec audace, rigueur et dans l’interdisciplinarité que les auteurs présentent les résultats de leurs recherches sur le thème « Didactique et pédagogie en aménagement flexible ».

- Wouter E.A. van Beek, Henri Maurier, Philosophie de L’Afrique Noire (2ème éd.), St. Augustin: Anthropos Institut, 1985. - Wouter E.A. van Beek, A.M. Hocart, Imagination and proof. Selected essays of A.M. Hocart, Edited and with an introduction by Rodney Needham, Tucson: University of Arizona Press, 1987. 130 pp. - Martin van Bruinessen, B.B. Hering, Studies on Indonesian Islam, Occasional Paper no. 19, Centre for Southeast Asian Studies, James Cook University of North Queensland, Townsville (Australia), 1986, 50 pp. - Martin van Bruinessen, B.B. Hering, Studies on Islam, Occasional Paper no. 22, Centre for Southeast Asian Studies, James Cook University of North Queensland, Townsville (Australia), 1987, 94 pp. - Martin van Bruinessen, L.B. Venema, Islam en macht: Een historisch-anthropolische perspectief, Assen/Maastricht: Van Gorcum, 1987. - H.J.M. Claessen, Colin Renfrew, Peer polity interaction and socio-political change, Cambridge: Cambridge University Press, 1986. 179 pp., maps, ills., index, bibl., John F. Cerry (eds.) - H. Dagmar, Fred R. Myers, Pintupi country, Pintupi self; Sentiment, place and politics among Western Desert aborigines, Washington etc.: Smithsonian Institution Press, Australian Institute of Aboriginal Studies. - Mies Grijns, Rosanne Rutten, Women workers of Hacienda Milagros; Wage labor and household subsistence on a Philippine sugar cane plantation. Publikatieserie Zuid- en Zuidoost-Azie no. 30, Amsterdam: Anthropologisch-Sociologisch Centrum, Universiteit van Amsterdam, 1982, x + 187 pp. - Mies Grijns, Ann Laura Stoler, Capitalism and confrontation in Sumatra’s plantation belt, 1870-1979, Newhaven: Yale University Press, 1985, xii + 244 pp. - Nico de Jonge, Rodney Needham, Mamboru. History and structure in a domain of Northwestern Sumba. Oxford: Clarendon Press, 1987, 202 pp. - Anton Ploeg, Kenneth E. Read, Return to the high valley. Coming full circle. Berkeley: University of California Press, 1986. xxi + 269 pp. - Rien Ploeg, Tom R. Zuidema, La Civilisation Inca au Cuzco, Collège de France, Essais et Conférences, Paris: Presses Universitaires de France, 1986. - Harry A. Poeze, E.E. van Delden, Klein repertorium; Index op tijdschriftartikelen met betrekking tot voormalig Nederlands-Indië, samengesteld door E. E. van Delden. Amsterdam: Koninklijk Instituut voor de Tropen. Deel 1, Tijdschrift voor het Binnenlandsch Bestuur 1887-1900, 1986, 79 pp. Deel 2, Tijdschrift voor het Binnenlandsch Bestuur 1900-1909, 1986 80 pp. Deel 3, Tijdschrift voor het Binnenlandsch Bestuur 1910-1917, 1987, 80 pp. - Harry A. Poeze, J.J.P. de Jong, Diplomatie of strijd; Een analyse van het Nederlands beleid tegenover de Indonesische revolutie 1945-1947. Amsterdam: Boom, 531 pp. - Harry A. Poeze, D.C.L. Schoonoord, De Mariniersbrigade 1943-1949; Wording en inzet in Indonesië. ‘s-Gravenhage: Afdeling Maritieme Historie van de Marinestaf. - R. de Ridder, Edmundo Magaña, Myth and the imaginary in the new world, Amsterdam: CEDLA, Latin America Studies no. 34, 1986. 500 pp. 64 ills., Peter Mason (eds.) - P.G. Rivière, Edmundo Magaña, Contribuciones al estudio de la mitología y astronomía de los indios de las Guayanas, Dordrecht-Providence: Foris Publications. 1987. - A. de Ruijter, P.E. de Josselin de Jong, Generalisatie in de culturele antropologie (Afscheidscollege ter gelegenheid van het neerleggen van het ambt van hoogleraar in de sociale wetenschappen aan de Rijksuniversiteit van Leiden op 12 juni 1987), 1987, Leiden: E.K. Brill. - Mary F. Somers Heidhues, Yoe-Sioe Liem, Überseechinesen - eine minderheit: Zur erforschung interethnischer vorurteile in Indonesien, Aachen: Edition Herodot im Rader-Verlag, 1986. - N.J.M. Zorgdrager, H. Beach, Contributions to circumpolar studies. Uppsala Research Reports in Cultural Anthropology no. 7, 1986. 181 pages.

Se presenta una síntesis de los antecedentes, el nacimiento y el desarrollo de la Bio-ética como disciplina contemporánea. Se busca llevar al lector desde el entorno en que surge la utilización del término ‘bioética’ en el mundo académico por Van Rensselaer Potter, hasta las discusiones actuales que propugnan el regreso al término ‘ética’ como respuesta a la necesidad de contar con una disciplina que sea aceptada por los denominados extraños morales en sociedades tan disímiles y pluralistas como las del mundo actual. Se hace una somera descripción de las principales tendencias de la bioética contemporánea para concluir que podemos interpretar a la bioética hoy, como un ‘grito’ en favor de la dignidad humana y de la convivencia pacífica y, a la vez, de la utilización de la ciencia y la tecnología en favor de una vida de calidad.

Autologous chimeric antigen receptor (CAR) T cells have achieved unprecedented clinical responses in patients with B-cell leukemias, lymphomas and multiple myeloma, raising interest in using CAR T cell therapies in AML. These therapies are produced using a patient's own T cells, an approach that has inherent challenges, including requiring significant time for production, complex supply chain logistics, separate GMP manufacturing for each patient, and variability in performance of patient-derived cells. Given the rapid pace of disease progression combined with limitations associated with the autologous approach and treatment-induced lymphopenia, many patients with AML may not receive treatment. Allogeneic CAR T (AlloCAR T) cell therapies, which utilize cells from healthy donors, may provide greater convenience with readily available off-the-shelf CAR T cells on-demand, reliable product consistency, and accessibility at greater scale for more patients. To create an allogeneic product, the TRAC and CD52 genes are inactivated in CAR T cells using Transcription Activator-Like Effector Nuclease (TALEN®) technology. These genetic modifications are intended to minimize the risk of graft-versus-host disease and to confer resistance to ALLO-647, an anti-CD52 antibody that can be used as part of the conditioning regimen to deplete host alloreactive immune cells potentially leading to increased persistence and efficacy of the infused allogeneic cells. We have previously described the functional screening of a library of anti-FLT3 single-chain variable fragments (scFvs) and the identification of a lead FLT3 CAR with optimal activity against AML cells and featuring an off-switch activated by rituximab. Here we characterize ALLO-819, an allogeneic FLT3 CAR T cell product, for its antitumor efficacy and expansion in orthotopic models of human AML, cytotoxicity in the presence of soluble FLT3 (sFLT3), performance compared with previously described anti-FLT3 CARs and potential for off-target binding of the scFv to normal human tissues. To produce ALLO-819, T cells derived from healthy donors were activated and transduced with a lentiviral construct for expression of the lead anti-FLT3 CAR followed by efficient knockout of TRAC and CD52. ALLO-819 manufactured from multiple donors was insensitive to ALLO-647 (100 µg/mL) in in vitro assays, suggesting that it would avoid elimination by the lymphodepletion regimen. In orthotopic models of AML (MV4-11 and EOL-1), ALLO-819 exhibited dose-dependent expansion and cytotoxic activity, with peak CAR T cell levels corresponding to maximal antitumor efficacy. Intriguingly, ALLO-819 showed earlier and more robust peak expansion in mice engrafted with MV4-11 target cells, which express lower levels of the antigen relative to EOL-1 cells (n=2 donors). To further assess the potency of ALLO-819, multiple anti-FLT3 scFvs that had been described in previous reports were cloned into lentiviral constructs that were used to generate CAR T cells following the standard protocol. In these comparative studies, the ALLO-819 CAR displayed high transduction efficiency and superior performance across different donors. Furthermore, the effector function of ALLO-819 was equivalent to that observed in FLT3 CAR T cells with normal expression of TCR and CD52, indicating no effects of TALEN® treatment on CAR T cell activity. Plasma levels of sFLT3 are frequently increased in patients with AML and correlate with tumor burden, raising the possibility that sFLT3 may act as a decoy for FLT3 CAR T cells. To rule out an inhibitory effect of sFLT3 on ALLO-819, effector and target cells were cultured overnight in the presence of increasing concentrations of recombinant sFLT3. We found that ALLO-819 retained its killing properties even in the presence of supraphysiological concentrations of sFLT3 (1 µg/mL). To investigate the potential for off-target binding of the ALLO-819 CAR to human tissues, tissue cross-reactivity studies were conducted using a recombinant protein consisting of the extracellular domain of the CAR fused to human IgG Fc. Consistent with the limited expression pattern of FLT3 and indicative of the high specificity of the lead scFv, no appreciable membrane staining was detected in any of the 36 normal tissues tested (n=3 donors). Taken together, our results support clinical development of ALLO-819 as a novel and effective CAR T cell therapy for the treatment of AML. Disclosures Sommer: Allogene Therapeutics, Inc.: Employment, Equity Ownership. Cheng:Allogene Therapeutics, Inc.: Employment, Equity Ownership. Yeung:Pfizer Inc.: Employment, Equity Ownership. Nguyen:Allogene Therapeutics, Inc.: Employment, Equity Ownership. Sutton:Allogene Therapeutics, Inc.: Employment, Equity Ownership. Melton:Allogene Therapeutics, Inc.: Employment, Equity Ownership. Valton:Cellectis, Inc.: Employment, Equity Ownership. Poulsen:Allogene Therapeutics, Inc.: Employment, Equity Ownership. Djuretic:Pfizer, Inc.: Employment, Equity Ownership. Van Blarcom:Allogene Therapeutics, Inc.: Employment, Equity Ownership. Chaparro-Riggers:Pfizer, Inc.: Employment, Equity Ownership. Sasu:Allogene Therapeutics, Inc.: Employment, Equity Ownership.

Las competencias que ejercen los ayuntamientos van adquiriendo más y más relevancia con el paso del tiempo y la evolución de estas tiene, además, entre sus principales características, una clara y directa afección a la vida diaria de sus habitantes. Las previsiones para un futuro próximo no hacen sino enfatizar este hecho, acarreando importantes desafíos para los gestores municipales, especialmente en las ciudades que conservan su patrimonio histórico como herencia y memoria de su evolución, y este se ha convertido además en elemento identificable y fuente de recursos para la propia ciudad. En el presente artículo se realizará un somero resumen de cuáles son estas características, y cómo los nuevos retos que se plantean convierten a las policías locales en una herramienta necesaria para la correcta gestión y conservación del patrimonio histórico en las ciudades, debido a su multidisciplinariedad y capacidades, pero centrándonos en las competencias urbanísticas de los municipios.

We investigated the nature of graphic formulas in 5-, 7-, and 9-year-old children when they were asked to draw a house and a television in a free condition, and then to draw from photographs of these objects. Assuming that the frequency of occurrence of a feature in children's drawings reflects its semantic weight, we studied the relations between occurrence and order of production of features to assess the extent to which a core-to-periphery progression principle (van Sommers, 1984) applies to the graphic formulas. The results showed that this principle was essentially present in the free drawing context. Under copying conditions, the order of production of the features was under the influence of perceptual and geometric factors, which elicited the production of subsystems of features at the depends of the application of the core-to-periphery progression principle. In the free condition, the core-to-periphery principle was mostly relevant in accounting for graphic formulas of the house in the young children (5 and 7 years), and of the television at ages 7 and 9. We suggest that the development of a graphic formula is partially related to the development of the object as a category in the child's conceptual system.

Avec l’Hommage à la femme noire (1988-1989), une encyclopédie en six tomes illustrée de nombreux documents iconographiques, Simone et André Schwarz-Bart ont voulu mettre en lumière, de la préhistoire au xxe siècle, le parcours de femmes noires oubliées par l’Histoire afin de se constituer une galerie d’ancêtres. Si ce projet est ambitieux, celui de traduire cette somme hybride l’est tout autant. Le présent article sera consacré aux enjeux de la traduction de cette encyclopédie du français vers l’anglais en contexte nord-américain. Les traducteurs Rose-Myriam Réjouis et Val Vinokurov ont effectivement pris des initiatives pour accompagner le lecteur anglophone, en apportant notamment certains éléments de contextualisation. Nous observerons ici les procédés mis en place pour traduire l’encyclopédie ainsi que les implications de ces choix de traduction.

Objetiva este texto desmontar o processo da escrita-composição evidenciando a importância de que se reveste o desdobramento do escritor/autor em diferentes papéis, que vão de leitor a editor, passando por investigador, descobridor, revisor e crítico. Observa-se, então, a diferença entre o exercício de todas essas funções pelo próprio autor e a sua assunção por diferentes agentes numa ótica da construção da obra pela divisão do trabalho, conforme propõe o narrador de S. Bernardo, de Graciliano Ramos, no início do romance. Para sustentar a argumentação necessária foi crucial o recurso a depoimentos de profissionais da escrita, porquanto atestam na primeira pessoa a dificuldade inerente a essa tarefa. A lição a retirar deste texto vai na direção de incentivar a prática desse processo verbal, com vista à melhor adequação da “execução” à “intenção” (Sommers, 1980), dado que a escrita só pode tornar-se menos distante e mais familiar, se for praticada com assiduidade e com informação acerca da sua dinâmica.

En este trabajo se estudia el poblamiento en la zona nordeste de Segovia en el periodo Celtibérico Antiguo, posiblemente con una serie de rasgos individualizadores, por su situación fronteriza con el mundo de El Soto. También se establecen las diferentes variables de un poblamiento que sería continuador en parte del de la etapa protoceltibérica; en todo caso, se caracteriza por la existencia de una serie de poblados en alto y en llano, sin vestigios de fortificaciones, junto con otros dos grandes poblados, uno de ellos fuertemente amurallado, y con necrópolis de incineración desde sus primeras etapas. Igualmente hemos destacado la creciente jerarquización de los asentamientos, unido a la concentración de la población desde época muy temprana, posiblemente como única opción para someter a grupos de habitantes por parte de las elites detentadoras del poder en los grandes poblados; así, se observa la progresiva desaparición de los asentamientos menores en beneficio de los que se van a convertir en grandes castros, para posteriormente, desaparecer alguno de ellos en el momento de la configuración de los oppida ya en el Celtibérico Pleno.

Chris Ballard, Paula Brown, R. Michael Bourke, Tracy Harwood (eds); The sweet potato in Oceania; A reappraisal (Peter Boomgaard) Caroline Hughes; The political economy of Cambodia’s transition, 1991-2001 (Han Ten Brummelhuis) Richard Robison, Vedi Hadiz; Reorganising power in Indonesia; The politics of oligarchy in an age of markets (Marleen Dieleman) Michael W. Charney; Southeast Asian warfare, 1300-1900 (Hans Hägerdal) Daniel Perret, Amara Srisuchat, Sombun Thanasuk (eds); Études sur l´histoire du sultanat de Patani (Mary Somers Heidhues) Joel Robbins; Becoming sinners; Christianity and moral torment in a Papua New Guinea society (Menno Hekker) Mujiburrahman; Feeling threatened; Muslim-Christian relations in Indonesia’s New Order (Gerry van Klinken) Marie-Odette Scalliet; De Collectie-Galestin in de Leidse Universiteitsbibliotheek (Dick van der Meij) James Neil Sneddon; Colloquial Jakartan Indonesian (Don van Minde) James Leach; Creative land; Place and procreation on the Rai coast of Papua New Guinea (Dianne van Oosterhout) Stanley J. Ulijaszek (ed.); Population, reproduction and fertility in Melanesia (Dianne van Oosterhout) Angela Hobart; Healing performances of Bali; Between darkness and light (Nathan Porath) Leo Suryadinata (ed.); Admiral Zheng He and Southeast Asia (Roderich Ptak) Ruth Barnes; Ostindonesien im 20. Jahrhundert; Auf den Spuren der Sammlung Ernst Vatter (Reimar Schefold) Marie-Antoinette Willemsen; Een missionarisleven in brieven; Willem van Bekkum, Indië 1936-1998 (Karel Steenbrink) Marie-Antoinette Willemsen; Een pionier op Flores; Jilis Verheijen (1908-1997), missionaris en onderzoeker (Karel Steenbrink) Akitoshi Shimizu, Jan van Bremen (eds); Wartime Japanese anthropology in Asia and the Pacific (Fridus Steijlen) Lilie Roosman; Phonetic experiments on the word and sentence prosody of Betawi Malay and Toba Batak (Uri Tadmor) Jamie D. Saul; The Naga of Burma; Their festivals, customs, and way of life (Nicholas Tapp) K.S. Nathan, Mohammad Hashim Kamali (eds); Islam in Southeast Asia; Political, social and strategic challenges for the 21st century (Bryan S. Turner) Andrew Pawley, Robert Attenborough, Jack Golson, Robin Hide (eds); Papuan pasts; Cultural, linguistic and biological histories of Papuan-speaking peoples (Lourens de Vries) Leo Howe, The changing world of Bali; Religion, society and tourism (Carol Warren) Sarah Weiss; Listening to an earlier Java; Aesthetics, gender, and the music of wayang in Central Java (Andrew N. Weintraub) REVIEW ESSAY Terry Crowley: Four grammars of Malakula languages Crowley, Terry (ed. by John Lynch); The Avava language of Central Malakula (Vanuatu) Crowley, Terry (ed. by John Lynch); Tape: a declining language of Malakula (Vanuatu Crowley, Terry (ed. by John Lynch); Naman: a vanishing language of Malakula (Vanuatu) Crowley, Terry (ed. by John Lynch); Nese: a diminishing speech variety of Northwest Malakula (Vanuatu) (Alexandre Francois) REVIEW ESSAY -- ‘The folly our descendants are least likely to forgive us’: the end of nature in Southeast Asia? Michael R. Dove, Percy E. Sajise, Amity A. Doolittle (eds); Conserving nature in culture; Case studies from Southeast Asia Jeyamalar Kathirithamby-Wells; Nature and nation; Forests and development in peninsular Malaysia Celia Lowe; Wild profusion; Biodiversity conservation in an Indonesian archipelago John F. McCarthy; The fourth circle; A political ecology of Sumatra’s rainforest frontier Budy P. Resosudarmo (ed.); The politics and economics of Indonesia’s natural resources Jeffrey R. Vincent, Rozali Mohamed Ali; Managing natural wealth; Environment and development in Malaysia (David Henley) In: Bijdragen tot de Taal-, Land- en Volkenkunde no. 163 (2007), no: 2/3, Leiden

- Jet Bakels, Robert Layton, The anthropology of art. Cambridge: Cambridge University Press, 1991, 258 pp. - J.M.S. Baljon, Herman Leonard Beck, De Islam in Nederland: Romancing religion? [Inaugurele rede theologische faculteit Tilburg 14.2.1992.] Tilburg: Tilburg University Press 1992. - R.H. Barnes, J.D.M. Platenkamp, North Halmahera: Non-Austronesian Languages, Austronesian cultures?, Lecture presented to the Oosters Genootschap in Nederland at Leiden on 23 May 1989, Leiden: Oosters Genootschap in Nederland, 1990. 33 pp. - Hans Borkent, Directory of Southeast Asianists in the Pacific Northwest. Compiled by: Northwest Regional Consortium for Southeast Asian Studies. Seattle, WA: University of Washington [et al.], 1990. 108 pp. - Roy Ellen, Frans Hüsken, Cognation and social organization in Southeast Asia. Verhandelingen van het Koninklijk Instituut voor Taal-, Land- en Volkenkunde 145. Leiden: KITLV Press, 1991, 221 pp. figs. tables, index., Jeremy Kemp (eds.) - C. de Jonge, Huub J.W.M. Boelaars, Indonesianisasi. Het omvormingsproces van de katholieke kerk in Indonesië tot de Indonesische katholieke kerk, Kerk en Theologie in Context, 13, Kampen: Kok, 1991, ix + 472 pp. - Nico de Jonge, Gregory Forth, Space and place in eastern Indonesia, University of Kent at Canterbury, Centre of South-east Asian Studies (Occasional Paper no. 16) 1991. 85 pp., ills. - J. Kommers, Bernard Juillerat, Oedipe chasseur. Une mythologie du sujet en Nouvelle-Guinée, P.U.F., Le fil rouge, section 1 Psychanalyse. Paris, 1991. - Gerco Kroes, Signe Howell, Society and cosmos, the Chewong of Peninsular Malaysia, University of Chicago Press, 1989, xv + 294 pp. - Daniel S. Lev, S. Pompe, Indonesian Law 1949-1989: A bibliography of foreign-language materials with brief commentaries on the law, Van Vollenhoven Institute for Law and Administration in Non-Western Countries. Nijhoff, 1992. - A. M. Luyendijk-Elshout, H. den Hertog, De militair geneeskundige verzorging in Atjeh, 1873-1904. Amsterdam, Thesis Publishers, 1991. - G.E. Marrison, Wolfgang Marschall, The Rejang of South Sumatra. Hull: Centre for South-east Asian Studies, 1992, iii + 93 pp., ill. (Occasional Papers no. 19: special issue)., Michele Galizia, Thomas M. Psota (eds.) - Harry A. Poeze, Marijke Barend-van Haeften, Oost-Indie gespiegeld; Nicolaas de Graaff, een schrijvend chirurgijn in dienst van de VOC. Zutphen: Walburg Pers, 1992, 279 pp. - Ratna Saptari, H. Claessen, Het kweekbed ontkiemd; Opstellen aangeboden aan Els Postel. Leiden: VENA, Faculty of Social Sciences, University of Leiden, P.O. Box 9555, 2300 RA., M. van den Engel, D. Plantenga (eds.) - Jerome Rousseau, James J. Fox, The heritage of traditional agriculture among the western Austronesians. Occasional paper of the department of Anthropology. Comparitive Austronesian Project. Research school of Pacific studies. Australian National University, Canberra, Australia, 1992. 89 pp. - Oscar Salemink, Gehan Wijeyewardene, Ethnic groups acrss National boundaries in mainland Southeast Asia. Singapore 1990, Institute of Southeast Asian studies (Social issues in Southeast Asia series). x + 192 pp. - Henk Schulte Nordholt, U. Wikan, Managing turbulent hearts. A Balinese formula for living, Chicago: University of Chicago Press. 1990, xxvi + 343 pp. photos. - Mary Somers Heidhues, Claudine Salmon, Le moment ‘sino-malais’ de la litterature indonesienne. [Cahier d’Archipel 19.] Paris: Association Archipel, 1992. - Heather Sutherland, J.N.F.M. à Campo, Koninklijke Paketvaart Maatschappij; Stoomvaart en staatsvorming in de Indonesische archipel 1888-1914, Hilversum: Verloren, (Erasmus Universiteit Rotterdam, Publikaties van de Faculteit der Historische en Kunstwetenschappen III), 1992, 756 pp., tables, graphics, photographs. - Gerard Termorshuizen, Robin W. Winks, Asia in Western fiction. Honolulu: University of Hawaii Press, 1990. x + 229 pp., James R. Rush (eds.) - John Verhaar, Lourens de Vries, The morphology of Wambon of the Irian Jaya Upper-Digul area. Leiden: KITLV Press, 1992, xiv + 98 pp., Robinia de Vries-Wiersma (eds.) - Maria van Yperen, Cornelia N. Moore, Translation East and West: A cross-cultural approach, Honolulu: University of Hawaii Press. xxv + 259 pp., Lucy Lower (eds.) - Harvey Whitehouse, Klaus Neumann, Not the way it really was: constructing the Tolai past. Honolulu: University of Hawaii Press, 1992.

Basing on an evaluation of the literature and some unpublished collections, 745 taxa of lichen forming-fungi are reported from the Venezuelan Andes, including 10 infraspecific taxa. Of these taxa 37 are new records for Venezuela: Actinoplaca vulgaris (Müll. Arg.) Vezda & Poelt, Asterothyrium decipiens (Rehm) R. Sant., Calopadia foliicola (Fée) Vezda, C. fusca (Müll. Arg.) Vezda, C. phyllogena (Müll. Arg.) Vezda, Chrysothrix chlorina (Ach.) J. R. Laundon, Cystocoleus ebeneus (Dillwyn) Thwaites, Diploschistes scruposus (Schreb.) Norm., Echinoplaca leucotrichoides (Vain.) R. Sant., Fellhanera bouteillei (Desm.) Vezda, F. dominicana (Vain.) Vezda, F. fuscatula (Müll. Arg.) Vezda, F. sublecanorina (Nyl.) Vezda, Gyalectidium filicinum Müll. Arg., Lecidea limosa Ach., Lepraria neglecta Auct., Ochrolechia africana Vain., Peltigera vainioi Gyelnik, Phyllobathelium nigrum R. Sant. & Tibell, Phyllophiale alba R. Sant., Polymeridium albidum (Müll. Arg.) R. C. Harris, Porina epiphylla (Fée) Fée, Racodium rupestre Pers., Ramalina asahinae W. Culb. & C. Culb., R. calcarata Krog & Swinsc., R. puiggarii Müll Arg., R. rectangularis Nyl., Rhizoplaca melanophthalma (DC.) Leuckert & Poelt, Strigula antillarum (Fée) Müll. Arg., S. platypoda (Müll. Arg.) R. C. Harris, Tapellaria epiphylla (Müll. Arg.) R. Sant., T. nana (Fée) R. Sant., Tephromela aglaea (Sommerf.) Hertel & Rambold, Tricharia vainioi R. Sant., Trichothelium epiphyllum Müll. Arg., T. bipindense F. Schill. and Vezdaea foliicola Sérusiaux. Another 4 species are new records only for the Venezuelan Andes: Dimerella epiphylla (Müll. Arg.) Malme, Porina atrocoerulea Müll. Arg., Ramalina peruviana Ach. and Woessia apiahica (Müll. Arg.) Sérus. A list of synonyms used in the consulted literature is added. Four new combinations are proposed: Dictyonema zahlbruckneri (Schiffn.) V. Marcano, Heterodermia tropica (Kurok.) Sipman, Parmelinopsis cleefii (Sipman) V. Marcano & Sipman and Phyllobaeis linearis (De Vries) V. Marcano & Sipman.

Zusammenfassung Von 2007 bis 2016 untersuchte ein interdisziplinäres Projekt im Unterengadin (Graubünden, Schweiz) die alpine Weidewirtschaft. Im Fimbertal/Val Fenga wurden in über 2000 m Höhe spätbronzezeitliche bzw. hallstattzeitliche Baustrukturen entdeckt, die in Verbindung mit zeitgleichen Talsiedlungen um Ramosch als Nachweis für eigentliche Alpwirtschaft in prähistorischer Zeit interpretiert werden. Um diese idealtypische Kombination eines gestuften Tal-Alp-Systems und die gesamtwirtschaftliche Bedeutung der Viehwirtschaft besser zu verstehen, wurde eine GIS-gestützte Szenarioevaluation der prähistorischen Landschaftsnutzung ausgeführt. Da zur Größe und Struktur der Siedlungen keine ausreichenden Daten vorhanden sind, wurde eine theoretische Berechnung der maximalen Bevölkerungs- bzw. Vieh-/Herdenzahl angestrebt. Die Basis dazu bildet ein komplexes Subsistenzmodell, das aus der archäologischen, physiologischen und landwirtschaftlichen Fachliteratur ausgearbeitet wurde und den Flächenbedarf von Ackerbau und Viehzucht berücksichtigt. Anhand separat modellierter landwirtschaftlicher Nutzungsflächen im Einzugsgebiet (site catchment) der jeweiligen Siedlung lässt sich so die maximale Tragkraft (carrying capacity) bzw. Bevölkerungszahl ermitteln. Die alpine Topografie wird dabei als landwirtschaftlich stark limitierender Faktor betrachtet, sodass eine wachsende Siedlung bzw. Bevölkerung dazu gezwungen wäre, das Vieh im Sommer auf weiter entfernte Hochweiden auszulagern. Aus den Modellen kann allerdings kein ökonomischer oder ökologischer Druck als primärer Grund für die Ausformung der Alpwirtschaft belegt werden. Es wäre in den Talsiedlungen möglich, Ackerbau und Viehwirtschaft für bis zu 200 Personen ganzjährig in unmittelbarer Siedlungsnähe zu bewerkstelligen. Die saisonale vertikale Mobilität muss daher aus anderen Gründen eingeführt worden sein, möglicherweise für die strategische Mehrproduktion landwirtschaftlicher Erzeugnisse für den inner- und transalpinen Gütertausch.

The article investigates the textual potential of concrete and multidirectional verbs of motion (based on the original and translated texts of P. Süskind “Die Geschichte von Herrn Sommer”). Textual specificity of verbs of motion is considered with the support of semantic-pragmatic features of the verb subsystems of two languages. For Russian verbs of motion, the concept of direction is relevant, since any movement is carried out in space by a certain trajectory (idti – hodit’, bresti – brodit’, letet’ – letat’, bezhat’ – begat’). In German, this parameter of motion is actualized only in the appropriate context with the help of adverbs of location and direction; prepositional-case constructions; direct complements and separable prefixes. In the semantic field “Movement / Verkehr” with the verb dominant there are lexical groupings, whose members, due to the lexico-grammatical and lexico-semantic valency of verbs, interpret different characteristics of the process of movement. The text's richness in units of different parts of speech with the meaning of motion (primarily verbs) organizes the narrative chronotope of the story: the semantics of space and time is actualized with the help of the lexicon of motion. Each of the main characters is included into the narrative through the description of the peculiarities of their movement. The following movement parameters are essential for the lexico-grammatical organization of the original and translated texts: direction, mode and means of movement, speed, purpose and actions associated with movement. In this textual paradigm, the key role belongs to concrete and multidirectional verbs. The main character lives his life in a constant, energetic, well-directed and aimless movement, unlike other characters, whose movements are determined by fatigue / vigor, vector (up / down, forward/backward), unidirectional and multidirectional, purpose and means of movement. In the semantics of concrete verbs there is a derivative potential seme “purpose of movement,” which, however, is extinguished in the original and translated texts. The main semantic paradox of the text is created by the intra-textual opposition of “a certain direction” and “no purpose” of the movements of the main character.

Over the past 40 years, extensive research has examined the effectiveness of mnemonics for vocabulary learning. Much of this research has investigated the keyword method (Atkinson & Raugh, 1975), which involves linking an image related to a to-be-learned L2 word with an image related to a similar-sounding L1 word. Whereas most research has shown the keyword method to be effective (Webb & Nation, 2017) with impressive long-term retention rates (Beaton, Gruneberg, & Ellis, 1995), some have questioned its usefulness, particularly due to the quality of the resulting lexical representations and extended latencies associated with recall (Barcroft, Sommers, & Sunderman, 2011; Van Hell & Candia Mahn, 1997). Other drawbacks of the keyword technique are the equating of dissimilar L1 and L2 phonemes and the difficulty in creating associations for languages with markedly different phoneme inventories. The current study presents a novel approach called the Homonym/Homophone Association Method (HAM). It overcomes some of the drawbacks of the keyword method by associating meanings of L2 homonyms or homophones, one known by the learner and one unknown. Because the pronunciations of the L2 target words are identical (or nearly identical), learners only need to associate two distinct meanings. A quasi-experiment (N = 71) employing a within-subjects design compared the effectiveness of (1) HAM using researcher-generated associations and images, (2) HAM using self-generated associations, and (3) production practice that involved writing target words in sentences. Results on an unannounced posttest given 3 weeks after instruction suggest an advantage for HAM using researcher-generated associations.

-Timothy P. Barnard, Cynthia Chou, Indonesian sea nomads; Money, magic, and fear of the Orang Suku Laut. London: RoutledgeCurzon, 2003, xii + 159 pp. -R.H. Barnes, Toos van Dijk, Gouden eiland in de Bandazee; Socio-kosmische ideeën op Marsela, Maluku Tenggara, Indonesië. Leiden: Onderzoekschool voor Aziatische, Afrikaanse en Amerindische studies (CNWS), Universiteit Leiden, 2000, 458 pp. [CNWS Publications 94.] -Andrew Beatty, Peter G. Riddell, Islam and the Malay-Indonesian world; Transmission and responses. Honolulu: University of Hawai'i Press, 2001, xvii + 349 pp. -Peter Boomgaard, Richard H. Grove ,El Niño - history and crisis; Studies from the Asia-Pacific region. Cambridge: White Horse Press, 2000, 230 pp., John Chappell (eds) -Bernardita Reyes Churchill, Florentino Rodao, Franco y el imperio japonés; Imágenes y propaganda en tiempos de guerra. Barcelona: Plaza and Janés, 2002, 669 pp. -Matthew Cohen, Stuart Robson, The Kraton; Selected essays on Javanese courts. Translated by Rosemary Robson-McKillop. Leiden: KITLV Press, 2003, xxvi + 397 pp. [Translation series 28.] -Serge Dunis, Ben Finney, Sailing in the wake of the ancestors; Reviving Polynesian voyaging. Honolulu: Bishop Museum Press, 2003, 176 pp. [Legacy of excellence.] -Heleen Gall, Jan A. Somers, De VOC als volkenrechtelijke actor. Deventer: Gouda Quint, Rotterdam: Sanders Instituut, 2001, x + 350 pp. -David Henley, Harold Brookfield, Exploring agrodiversity. New York: Columbia University Press, 2001, xix + 348 pp. -David Hicks, Ernst van Veen ,A guide to the sources of the history of Dutch-Portuguese relations in Asia (1594-1797). With a foreword by Leonard Blussé. Leiden: Institute for the history of European expansion, 2001, iv + 378 pp. [Intercontinenta 24.], Daniël Klijn (eds) -Nico Kaptein, Donald J. Porter, Managing politics and Islam in Indonesia. London: RoutledgeCurzon, 2002, xxi + 264 pp. -Victor T. King, Monica Janowski, The forest, source of life; The Kelabit of Sarawak. London: British Museum Press, 2003, vi + 154 pp. [Occasional paper 143.] -Dick van der Meij, Andrée Jaunay, Exploration dans la presqu île malaise par Jacques de Morgan 1884. Paris: CNRS Éditions, 2003, xiv + 268 pp. Avec les contributions de Christine Lorre, Antonio Guerreiro et Antoine Verney. -Toon van Meijl, Richard Eves, The magical body; Power, fame and meaning in a Melanesian society. Amsterdam: Harwood academic, 1998, xxii + 302 pp. [Studies in Anthropology and History 23.] -Otto van den Muijzenberg, Florentino Rodao ,The Philippine revolution of 1896; Ordinary lives in extraordinary times. Quezon city: Ateneo de Manila University Press, 2001, xx + 303 pp., Felice Noelle Rodriguez (eds) -Frank Okker, Kees Snoek, Manhafte heren en rijke erfdochters; Het voorgeslacht van E. du Perron op Java. Leiden: KITLV Uitgeverij, 2003, 103 pp. [Boekerij 'Oost en West'.] (met medewerking van Tim Timmers) -Oona Thommes Paredes, Greg Bankoff, Cultures of disaster; Society and natural hazard in the Philippines, 2003, xviii + 232 pp. London: RoutledgeCurzon, 2003, xviii + 232 pp. -Angela Pashia, Lake' Baling, The old Kayan religion and the Bungan religious reform. Translated and annotated by Jérôme Rousseau. Kota Samarahan: Unit Penerbitan Universiti Malaysia Sarawak, 2002, xviii + 124 pp. [Dayak studies monographs, Oral literature series 4.] -Anton Ploeg, Susan Meiselas, Encounters with the Dani; Stories from the Baliem Valley. New York: International center of photography, Göttingen: Steidl, 2003, 196 pp. -Nathan Porath, Robert W. Hefner, The politics of multiculturalism; Pluralism and citizenship in Malaysia, Singapore, and Indonesia. Honolulu: University of Hawai'i Press, 2001, ix + 319 pp. -Jan van der Putten, Timothy P. Barnard, Multiple centres of authority; Society and environment in Siak and eastern Sumatra, 1674-1827. Leiden: KITLV Press, 2003, xvi + 206 pp. [Verhandelingen 210.] -Jan Piet Puype, David van Duuren, Krisses; A critical bibliography. Wijk en Aalburg: Pictures Publishers, 2002, 192 pp. -Thomas H. Slone, Gertrudis A.M. Offenberg ,Amoko - in the beginning; Myths and legends of the Asmat and Mimika Papuans. Adelaide: Crawford House, 2002, xxviii + 276 pp., Jan Pouwer (eds) -Fridus Steijlen, Kwa Chong Guan ,Oral history in Southeast Asia; Theory and method. Singapore: Institute of Southeast Asian studies, 2000, xii + 172 pp., James H. Morrison, Patricia Lim Pui Huen (eds) -Fridus Steijlen, P. Lim Pui Huen ,War and memory in Malaysia and Singapore. Singapore: Institute of Southeast Asian studies, 2000, vii + 193 pp., Diana Wong (eds) -Jaap Timmer, Andrew Lattas, Cultures of secrecy; Reinventing race in Bush Kaliai cargo cults. Madison/London: University of Wisconsin Press, 1998, xliv + 360 pp. -Edwin Wieringa, Kartika Setyawati ,Katalog naskah Merapi-Merbabu; Perpustakaan Nasional Republik Indonesia. Yogyakarta: Penerbitan Universitas Sanata Dharma, Leiden: Opleiding Talen en Culturen van Zuidoost-Azië en Oceanië, 2002, ix + 278 pp. [Semaian 23.], I. Kuntara Wiryamartana, Willem van der Molen (eds) -Julian Millie, Jakob Sumardjo, Simbol-simbol artefak budaya Sunda; Tafsir-tafsir pantun Sunda. Bandung: Kelir, 2003, xxvi + 364 pp. -Julian Millie, T. Christomy, Wawacan Sama'un; Edisi teks dan analisis struktur Jakarta: Djambatan (in cooperation with the Ford Foundation), 2003, viii + 404 pp. -Julian Millie, Dadan Wildan, Sunan Gunung Jati (antara fiksi dan fakta); Pembumian Islam dengan pendekatan struktural dan kultural. Bandung: Humaniora Utama Press, 2002, xx + 372 pp.

En la actualidad, tanto en el sistema sanitario de España como en el del Reino Unido, todo paciente que se tenga que someter a un procedimiento médico tiene el derecho a que un profesional sanitario le explique este procedimiento y, tras ser informado, tiene el derecho a consentir que se lleve a cabo o no. Uno de los objetivos principales de esta investigación es analizar la redacción de los consentimientos informados en español y en inglés para comprobar si se cumple una de las características principales de los consentimientos informados. Esta característica es el hecho de ser comprensible para los pacientes, para que, sin tener amplios conocimientos sobre el ámbito médico, puedan comprender el procedimiento al que se van a someter y decidir si quieren que se realice o no. El otro objetivo principal es analizar el consentimiento informado desde el punto de vista del hecho de ser un texto híbrido, comparando la cantidad de terminología e información del ámbito médico con la perteneciente al ámbito jurídico. Se trata de un estudio comparativo en el que, tras el análisis, por una parte, de los consentimientos informados en inglés y, por otra parte, de los consentimientos informados en español, se compare la redacción entre ambos idiomas. Para ello, se ha compilado un corpus de 50 consentimientos informados en inglés y 50 consentimientos informados en español de 50 temáticas distintas procedentes de distintas instituciones sanitarias de España y del Reino Unido. En este análisis se tendrán en cuenta aspectos relacionados con la macroestructura y la microestructura de cada texto como, por ejemplo, organización general de la información, registro, y terminología, entre otros. Los resultados apoyan la característica del consentimiento informado de ser un texto híbrido puesto que, por ejemplo, en cuanto a la cantidad de terminología especializada, el número entre la médica y la jurídica es muy similar. Además, se muestra que la redacción en inglés es mucho más cercana al lector que la de los textos redactados en español.

- Leonard Y. Andaya, H.A. Poeze, Excursies in Celebes; Een bundel bijdragen bij het afscheid van J. Noorduyn als directeur-secretaris van het Koninklijk Instituut voor Taal-, Land- en Volkenkunde. Leiden: KITLV Uitgeverij, 1991, 348 pp., P. Schoorl (eds.) - Anne Booth, Adrian Clemens, Changing economy in Indonesia Volume 12b; Regional patterns in foreign trade 1911-40. Amsterdam: Royal Tropical Institute, 1992., J.Thomas Lindblad, Jeroen Touwen (eds.) - A.P. Borsboom, James F. Weiner, The empty place; Poetry space, and being among the Foi of Papua New Guinea. Bloomington: Indiana University Press, 1991. - Martin van Bruinessen, Ozay Mehmet, Islamic identity and development; Studies of the Islamic periphery. London and New York: Routledge, 1990 (cheap paperback edition: Kula Lumpur: Forum, 1990), 259 pp. - H.J.M. Claessen, Timothy Earle, Chiefdoms: power, economy, and ideology. A school of American research book. Cambridge: Cambridge University Press, 1991. 341 pp., bibliography, maps, figs. - H.J.M. Claessen, Henk Schulte Nordholt, State, village, and ritual in Bali; A historical perspective. (Comparitive Asian studies 7.) Amsterdam: VU University press for the centre for Asian studies Amsterdam, 1991. 50 pp. - B. Dahm, Ruby R. Paredes, Philippine colonial democracy. (Monograph series 32/Yale University Southeast Asia studies.) New Haven: Yale Center for international and Asia studies, 1988, 166 pp. - Eve Danziger, Bambi B. Schieffelin, The give and take of everyday life; Language socialization of Kaluli children. (Studies in the social and cultural foundations of language 9.) Cambridge: Cambridge University Press, 1991. - Roy Ellen, David Hicks, Kinship and religion in Eastern Indonesia. (Gothenburg studies in social anthropology 12.) Gothenburg: Acta Universitatis Gothoburgensis, 1990, viii 132 pp., maps, figs, tbls. - Paul van der Grijp, Pierre Lemonnier, Guerres et festins; Paix, échanges et competition dans les highlands de Nouvelle-Guinée. (avant-propos par Maurice Godelier). Paris: Éditions de la Maison des Sciences de l’Homme, 1990, 189 pp. - F.G.P. Jaquet, Hans van Miert, Bevlogenheid en onvermogen; Mr. J.H. Abendanon en de Ethische Richting in het Nederlandse kolonialisme. Leiden: KITLV Uitgeverij, 1991. VI 178 pp. - Jan A. B. Jongeneel, Leendert Jan Joosse, ‘Scoone dingen sijn swaere dingen’; een onderzoek naar de motieven en activiteiten in de Nederlanden tot verbreiding van de gereformeerde religie gedurende de eerste helft van de zeventiende eeuw. Leiden: J.J. Groen en Zoon, 1992, 671 pp., - Barbara Luem, Robert W. Hefner, The political economy of Mountain Java; An interpretive history. Berkeley: University of California Press, 1990. - W. Manuhutu, Dieter Bartels, Moluccans in exile; A struggle for ethnic survival; Socialization, identity formation and emancipation among an East-Indonesian minority in The Netherlands. Leiden: Centre for the study of social conflicts and Moluccan advisory council, 1989, xiii 544 p. - J. Noorduyn, Taro Goh, Sumba bibliography, with a foreword by James J. Fox, Canberra: The Australian National University, 1991. (Occasional paper, Department of Anthropology, Research school of Pacific studies.) xi 96 pp., map, - J.G. Oosten, Veronika Gorog-Karady, D’un conte a l’autre; La variabilité dans la litterature orale/From one tale to the other; Variability in oral literature. Paris: Centre National de la Recherche Scientifique, 1990 - Gert Oostindie, J.H. Galloway, The sugar cane industry: An historical geography from its origins to 1914. Cambridge (etc.): Cambridge University Press, 1989. xiii 266 pp. - J.J. Ras, Peter Carey, The British in Java, 1811-1816; A Javanese account. Oriental documents X, published for the British academy by Oxford University Press, 1992, xxii 611 pp., ills., maps. Oxford: Alden press. - Ger P. Reesink, Karl G. Heider, Landscapes of emotion; Mapping three cultures of emotion in Indonesia. Cambridge: Cambridge University Press, Paris: Editions de la Maison des Sciences de l’Homme. 1991, xv 332 p. - Ger P. Reesink, H. Steinhauer, Papers on Austronesian linguistics No. 1. Canberra: Department of linguistics, Research school of Pacific studies, ANU. (Pacific linguistics series A- 81). 1991, vii 225 pp., - Janet Rodenburg, Peter J. Rimmer, The underside of Malaysian history; Pullers, prostitutes, plantation workers...Singapore: Singapore University Press, 1990, xiv 259 p., Lisa M. Allen (eds.) - A.E.D. Schmidgall-Tellings, John M. Echols, An Indonesian-English Dictionary. Third edition. Revised and edited by John U.Wolff and James T. Collins in in cooperation with Hasan Shadily. Ithaca and London: Cornell University Press, 1989. xix + 618 pp., Hasan Shadily (eds.) - Mary F. Somers Heidhues, Olaf H. Smedal, Order and difference: An ethnographic study of Orang Lom of Bangka, West Indonesia, Oslo: University of Oslo, Department of social anthropology, 1989. [Oslo Occasional Papers in Social Anthropology, Occasional Paper no. 19, 1989]. - E.Ch.L. van der Vliet, Henri J.M. Claessen, Early state economics. New Brunswick and London: Transaction Publishers, 1991 [Political and Anthropology Series volume 8]., Pieter van de Velde (eds.) - G.M. Vuyk, J. Goody, The oriental, the ancient and the primitive; Systems of marriage and the family in the pre-industrial societies of Eurasia. New York, Cambridge University Press, (Studies in literacy, family, culture and the state), 1990, 562 pp. - E.P. Wieringa, Dorothée Buur, Inventaris collectie G.P. Rouffaer. Leiden: Koninklijk Instituut voor Taal-, Land- en Volkenkunde, 1990, vi 105 pp., 6 foto´s.

AbstractPhilips Wouwerman(s) was undoubtedly the most accomplished and successful Dutch painter of equestrian scenes in the 17th century. Even so, neither a critical study of his work nor a documented biography has been published. The present essay not only presents the results of archive research but also outlines his artistic development. Besides the seven dated pictures by the artist known by Hofstede de Groot, several others have been discovered. Wouwerman was born in Haarlem, the eldest son of the painter Pouwels Joosten and his fourth wife, Susanna van den Bogert. Two other sons, Pieter and Johannes Wouwerman, were also to become painters. Wouwerman's grandfather originally came from Brussels. Philips probably received his first painting lessons from his father, none of whose work has been identified however, making it impossible to determine the extent of his influence on the son's work. According to Cornelis de Bie, Wouwerman was next apprenticed to Frans Hals. He is subsequently reputed to have spent several weeks in 1638 or 1639 working in Hamburg in the studio of the German history painter Evert Decker. In Hamburg he married Annetje Pietersz van Broeckhof. On 4 September 1640 Wouwerman became a member of the Haarlem painters' guild, in which he held the office of vinder in 1646. In the following years his presence in Haarlem is mentioned repeatedly. In view of the many southern elements in his landscapes it has frequently been suggested that Wouwerman travelled to France or Italy. However, there is no documentary evidence of his having left Haarlem for any length of time. Wouwerman died on 19 May 1668 and was buried on 23 May 1668 in the Nieuwe Kerk in Haarlem. He evidently attained a certain degree of prosperity, going by the relatively large sums of money each of his seven children inherited on his widow's death in 1670 and by the various houses he owned. No confirmation can be found of Arnold Houbraken's often quoted remark that Wouwerman's daughter Ludovica brought a dowry of 20,000 guilders with her in 1672 when she married the painter Hendrik de Fromantiou (1633/34 - after 1694). Wouwerman's oeuvre consists mainly of small cabinet pieces with horses, such as battle and hunting scenes, army camps, smithies and interiors of stables. He also painted sensitively executed silvery-grey landscapes, genre pieces and a few original representations of religious and mythological scenes. Wouwerman was also exceptionally prolific. Although he only lived to the age of 48, more than a thousand paintings bear his name. Even when one bears in mind that a number of these paintings should actually be attributed to his brothers Pieter and Jan, Philips left an extraordinarily large oeuvre. Only a small number of drawings by his hand are known. His pupils include Nicolaes Ficke, Jacob Warnars, Emanuel Murant and his brothers Pieter (1623-1682) and Jan Wouwerman (1629-1666). He had many followers and his paintings were much sought after in the i8th and early 19th centuries, especially in France. Important collections created during that period, including those which form the nuclei of the museums in St Petersburg, Dresden and The Hague, all contain a large number of his works. Establishing a chronology with respect to Philips Wouwerman's work is extremely problematic. His extensive oeuvre notwithstanding, only a comparatively small number of paintings are dated. The style of the signature enables us to date pictures only within wide margins: the monogram composed of P, H, and W was only used before 1646; thenceforth he used a monogram composed of PHILS and W. Wouwerman's earliest dated work, of 1639 (sale London, Christie's, October 10, 1972), is of minor quality. However, during the 1640s his talents improved rapidly. During that period he was strongly influenced by the Haarlem painter Pieter van Laer (1599 - after 1642) with respect to both style and subject matter. This tallies with Houbraken's remark that Wouwerman laid his hands on sketches and studies by Van Laer after that artist's death. Van Laer's influence is evident in Attack on a Coach, dated 1644, in the collection of the Prince of Liechtenstein, Vaduz. Several figures and details are quotations from works by Van Laer. Most of Wouwerman's compositions of the mid-1640os are dominated by a diagonally placed hill or dune covering most of the horizon, a tree - often dead - as a repoussoir and a few rather large figures, usually with horses. Landscape with Peasants Merrymaking in front of a Cottage in the City Art Gallery, Manchester, Battle Scene in the National Gallery, London and Landscape with a Resting Horseman in the Museum der Bildcnden Künste, Leipzig, all dated 1646, are proof that Wouwerman gradually developed his own style; nonetheless, Van Laer continued to be an important source of inspiration. As demonstrated by the four known dated paintings of 1649, the artist had replaced his sombre palette for a more colourful one by that time, and had also adopted a predominantly more horizontal scheme for his compositions. During that same period Wouwerman' pictures came to reflect a growing interest in landscape, and in the first half of the 1650s he produced a number of paintings which bear witness to his mastery of the landscape idiom. In a Landscape with Horsemen, of 1652, in a private British collection, painted in silvery tones, the figures and horses are reduced to a fairly insignificant staffage. Genre elements continued to play an important role in most of his paintings, though. One of his most successful works of that period is the Festive Peasants before a Panorama, dated 1653, in the Minneapolis Institute of Arts. Perhaps nowhere else in his oeuvre did the artist succeed in producing such a happy synthesis of genre and landscape elements. In the second half of the 1650s Wouwerman painted many of the fanciful hunting scenes - often with a vaguely Italian setting and brighter local colours - which were particularly sought after in the 18th and early 19th centuries. Only a few dated works from the last decade of his life have been preserved, but they do show a tendency towards more sombre colours and suggest a slight decline in his artistic skills. Van Laer's stylistic influence on Wouwerman had almost disappeared by then, although it continued to play a major role in terms of subject matter. After the middle of the 19th century Wouwerman's popularity waned, but more recently his work has met with increasing acclaim.

Se reportan resultados iniciales del estudio interdisciplinario de la secuencia lacustre de Laguna Santa Rosa, en el núcleo de 26 m de longitud recuperado en el sector norte-centro. Santa Rosa es una cuenca intermontaña, con una reducida zona de captación, altitud de 1520 m snm, y situada en el sector central de la Sierra Madre Oriental en la región de Iturbide en el noreste de México. Las variaciones estratigráficas de las propiedades magnéticas, contenido total de carbonato y carbón isotópico y mineralógico, definen tres zonas separadas por incrementos del cociente de calcita a quarzo+phyllosilicatos+feldespatos. La zona más somera, desde la superficie hasta 7-9 m, está formada por arcilla orgánica con abundancia de gasterópodos y dos arcillas de color negro a verde. Se caracteriza por susceptibilidad magnética alrededor de SI, factor de frecuencia de 0 %, 13 C que abarca desde -20.3 % a -26.4 %, presencia de cuarzo y phylosilicatos casi siempre con más de 20 % de calcita y esporádica aparición de plagioclasa (albita) y escaso contenido de K-feldespatos. La zona media, desde 9 m hasta 17.5 m, está formada por cinco unidades de arcilla que varían desde el verde grisáceo al café. Esta zona se caracteriza por su susceptibilidad variable arriba de 17 SI, factores de frecuencia negativos, bajo contenido total de carbonato, enriquecimiento de cuarzo y phylosilicatos, menos calcita y presencia de k-feldespatos. Esta zona media muestra un incremento en el aporte de detritos y/o productividad reducida, lo que sugiere un intervalo frío y menos húmedo. La zona más baja se extiende desde 17.5 m hasta 26 m y muestra dos unidades de arcilla que van del café al verde grisáceo. Esta zona se caracteriza por susceptibilidad magnética entre 8 10-6 SI y 14 SI, factor variable de frecuencia, y valores 13 C de alrededor -24 %. Su mineralogía es similar a la de la zona más somera, también rica en calcita y aparición de plagioclasa. La porción de phylosilicatos está compuesta principalmente de micas, clorita, esmectita y kaolinita. Los minerales magnéticos son alogénicos, derivados de lutitas y carbonatos que forman la cuenca de la zona de captación.

La peritonitis bacteriana espontánea (PBE) es una de las principales complicaciones de los pacientes cirróti- cos con ascitis y tiene gran importancia por las altas tasas de mortalidad y de recurrencia que presenta y que pueden mejorar considerablemente si se tiene un diagnóstico oportuno y se brinda el tratamiento óptimo. Es de tener en cuenta que, incluso en pacientes asintomáticos, se ha documentado una alta prevalencia de PBE. La profilaxis primaria y secundaria se constituye como una medida de gran relevancia al mejorar la sobrevida y disminuir las tasas de incidencia o recurrencia; sin embargo, deben ser aplicadas con mucha rigurosidad y con un buen seguimiento de los pacientes que van a ser sometidos a las mismas con el fin de prevenir la aparición de resistencia antibiótica. Algunos de los factores determinantes para someter a un paciente a profilaxis antibiótica son: episodio previo de PBE, pacientes con hemorragia de tracto digestivo y pacientes con evidencia de disfunción hepática dada por bajas concentraciones de proteínas en líquido ascítico e hiperbilirrubinemia. Con el uso de las principales bases de datos biomédicas (PubMed, ClinicalKey, EBSCO, Scielo, Scopus y OVID) se hizo una revisión de la literatura médica referente a la PBE, publicada tanto en español como en inglés, durante los últimos 5 años; dentro de esta se encontraron referencias bibliográficas muy valiosas, las cuales también fueron consultadas. Se evidenció cómo hay pocas publicaciones tanto a nivel latinoamericano como colombiano, dentro de las cuales se referencian algunas escritas por el mismo autor o por su grupo de trabajo.

Ecobiological study of medicinal plants includes the analysis of particular soil features and the ecological indexes of plant species as site indicators. Two experimental serpentine areas in northwest and central Serbia were selected to identify the potential limiting factors for medicinal plant harvesting. Soil analysis is done according to ICP methodology – ICP Forest Manual, Part III, Soil Sampling and Analysis (1998). Floristic and phytocoenological investigations were carried out by Wasthoff-van der Maarel (1973). The assessment of soil quality is based on the calculation of indicator values of available nitrogen (N), heavy metals, and the sensitivity to acidification. According to our results, N (12.1–17.5), acidification (7–12), and indicator values for some heavy metals (0.3–46.5) show a low biological availability. Medicinal plant species at the investigated areas have low values of ecological indexes: N (2.41–2.82), moisture (2.45–2.70) and soil acidity (3.35–3.70). Hydrothermic conditions indicate the predominant presence of sub-xerophytes, semi-sciophytes and mesothermic species. These types of plant species are recommended for exploitation.