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Books on the topic 'Vaccine discovery'

Author: Grafiati
Published: 4 June 2021
Last updated: 7 February 2022

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1

Institute of Medicine (U.S.). Committee on the Review of Priorities in the National Vaccine Plan. Priorities for the national vaccine plan. Washington, DC: National Academies Press, 2010.

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2

Hargrove, Jim. The story of Jonas Salk and the discovery of the polio vaccine. Chicago: Childrens Press, 1990.

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3

N, Denoncourt Rena, and Warner Anjli C, eds. U.S. vaccine markets: Overview and four case studies. Washington, D.C: AEI Press, 2009.

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4

Bredeson, Carmen. Jonas Salk: Discoverer of the polio vaccine. Hillside, N.J: Enslow Publishers, 1993.

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5

Development of vaccines: From discovery to clinical testing. Hoboken, N.J: John Wiley & Sons, 2011.

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6

Flower, Darren R., and Yvonne Perrie, eds. Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-5070-2.

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7

New York Academy of Sciences. Pharmaceutical science to improve the human condition: Prix Galien 2011 : winners and finalist candidate of the Prix Galien USA Awards 2011. Malden, MA: Wiley Periodicals, 2012.

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8

Harris, Duchess. The Discovery of the Polio Vaccine. Core Library, 2018.

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9

Palatnik-de-Sousa, Clarisa Beatriz, Irene da Silva Soares, and Daniela Santoro Rosa, eds. Epitope Discovery and Synthetic Vaccine Design. Frontiers Media SA, 2018. http://dx.doi.org/10.3389/978-2-88945-522-5.

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10

Jonas Salk and the Polio Vaccine (Inventions and Discovery). Capstone Press, 2006.

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11

Institute of Medicine (U.S.). Committee on the Review of Priorities in the National Vaccine Plan. and Institute of Medicine (U.S.). Board on Population Health and Public Health Practice., eds. Priorities for the national vaccine plan. Washington, DC: National Academies Press, 2010.

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12

Feemster, Kristen A. Vaccines. Oxford University Press, 2017. http://dx.doi.org/10.1093/wentk/9780190277901.001.0001.

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Immunization is regarded by many as one of the greatest advances in modern civilization. The widespread use of vaccines has led to increases in life expectancy, reductions in the occurrence of childhood diseases, and is generally credited with saving millions of lives annually. But since their discovery two centuries ago, vaccines have been dogged by pockets of persistent distrust among those who are skeptical of their science or who find compulsory immunization at odds with personal liberty. The rise of these voices in contemporary culture has contributed to trends of vaccine delay and vaccine hesitancy in some communities -- a chasm between the general population and the scientific establishment that has persisted and grown at times across the last several decades. VACCINES: What Everyone Needs to Know® offers a scientifically grounded overview of the science, manufacture, and culture of vaccines in the United States and internationally. Aiming to offer an unbiased resource on this hotly debated subject, it provides accessible, authoritative overviews of the following: · How vaccines work · The history of vaccines · Vaccine policy -- who writes it, and does it matter? · The contents and manufacture of vaccines · Vaccine injury · The alleged link between vaccines and autism · Vaccines and new outbreaks Written by a leading authority in both infectious disease and vaccine education, this book offers a clear-eyed resource for parents or anyone with an interest in the use, efficacy, and controversy surrounding vaccines. In a subject area defined by partisanship, it offers reliable resource for what everyone needs to know.
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13

Glanville, Jacob, Prabakaran Ponraj, and Gregory C. Ippolito, eds. Next-Generation Sequencing of Human Antibody Repertoires for Exploring B-cell Landscape, Antibody Discovery and Vaccine Development. Frontiers Media SA, 2020. http://dx.doi.org/10.3389/978-2-88963-951-9.

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14

Theophilus, Robert. Confessions of a Catholic Scientist : The Quest for a Malaria Vaccine and the Quest for God: A Journey of Discovery. Leonine Publishers, 2017.

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15

(Editor), Michael A. Morse, Timothy M. Clay (Editor), and H. Kim Lyerly (Editor), eds. Handbook of Cancer Vaccines (Cancer Drug Discovery and Development). Humana Press, 2004.

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16

Cox, Josephine H., Stuart Z. Shapiro, Liza Dawson, Cynthia Geppert, Andrew M. Siegel, and M. Patricia D’Souza. Vaccines for The Prevention and Treatment of HIV Infection. Edited by Mary Ann Cohen, Jack M. Gorman, Jeffrey M. Jacobson, Paul Volberding, and Scott Letendre. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199392742.003.0032.

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While the HIV/AIDS pandemic continues, the overall incidence of HIV infections has fallen through use of antiretroviral therapy (ART) and multiple prevention modalities. To achieve a durable end to the pandemic and avoid the requirement for daily antiretroviral medication over a lifetime, a safe and effective prophylactic vaccine remains essential. This chapter reviews current advances in prophylactic and therapeutic HIV-1 vaccine strategies and the challenges that lie ahead. Recent success in isolation of potent broadly neutralizing antibodies (bnAbs) from infected individuals, the discovery of mechanisms of bnAb induction, and progress in understanding mechanisms of CD8 T-cell killing of HIV-infected cells and the structure of the HIV envelope trimer have opened new strategies for HIV vaccine design. On the therapeutic front, the persistence of HIV reservoirs remains a formidable obstacle to achieving sustained virological remission in HIV-infected individuals after ART is discontinued. Development of a new generation of immune-based therapeutic agents might contribute to a curative intervention. The chapter closes with an overview of ethical challenges in vaccine development and clinical testing.
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17

Gilsdorf, Janet R. Continual Raving. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780190677312.001.0001.

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This book explores the lives and work of scientists who unraveled the mysteries of meningitis and describes the steps (and sometimes missteps) they used to accomplish their splendid achievements. Although symptoms of meningitis were recorded as early as the time of Hippocrates, its origin remained obscure. Then, in 1892, one of the bacteria that cause meningitis in children, Haemophilus influenzae, was discovered when Richard Pfeiffer saw it in material coughed up by a patient with influenza. Pfeiffer mistakenly thought the bacteria caused influenza, and it has carried that unfortunate, erroneous name since that time. Discovery, however, marched forward, and Quincke discovered how to obtain spinal fluid by inserting a needle between two bones in the patient’s back. Pittman discovered the sugar overcoat that protects H. influenzae from being eaten by white blood cells. Flexner managed epidemics of meningitis with serum from a horse. Griffith unknowingly stumbled on DNA, the master of all life. Weech gave the first antibiotic used in America to a little girl with meningitis. Alexander learned why antibiotics sometimes fail in such patients. Smith won the Nobel Prize for showing how DNA invades bacteria, the right conclusion for the wrong reasons. And four scientists, in two teams, vied to be the first to create the best vaccine to prevent meningitis in infants.
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18

Ramírez, Paul. Enlightened Immunity. Stanford University Press, 2018. http://dx.doi.org/10.11126/stanford/9781503604339.001.0001.

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A history of epidemics and disease prevention in eighteenth- and early nineteenth-century Mexico, Enlightened Immunity focuses on the multiethnic and multimedia production of medical knowledge in a time when the governance of healthy populations was central to the pursuits of absolutist monarchies. The book reconstructs the cultural, ritual, and political background of Mexico’s early experiments with childhood vaccines, tracing how the public health response to epidemic disease was thoroughly enmeshed with religion and the church, the spread of Enlightenment ideas about medicine and the body, and the customs and healing practices of indigenous villages. It was not only educated urban elites—doctors and men of science—whose response to outbreaks of disease mattered. Rather, the cast of protagonists crossed ethnic, gender, and class lines: local officials who decided if and how to execute plans that came from Mexico City, rural priests who influenced local practices, peasants and artisans who reckoned with the consequences of quarantine, and Indian tributaries who decided if they would hand their children to vaccinators. By following the public response to anticontagion measures and smallpox vaccine in colonial Mexico, Enlightened Immunity sheds light on fundamental questions about trust, uncertainty, and the role of religion in a period of medical discovery, innovation, and modernization.
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19

Bhole, Malini, Mas Chaponda, and Nick Beeching. Human immunodeficiency virus infection. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0296.

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Since its discovery in the 1980s, infection with the human immunodeficiency virus (HIV) has rapidly spread across the world, especially to large parts of the African continent. By the end of 2013, an estimated 35 million people were living with HIV worldwide. In the UK, this figure was close to 108 000 (a prevalence of 2.8 per 1 000 population aged 15–59 years (1.9 per 1000 women and 3.7 per 1000 men)). Significant progress has been made in diagnosis, and current treatments are life-saving. However, there is still no cure and no vaccine. This chapter addresses the clinical features and management of HIV infection.
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20

(Editor), Michael A. Morse, Timothy M. Clay (Editor), and H. Kim Lyerly (Editor), eds. Handbook of Cancer Vaccines (Cancer Drug Discovery and Development). Humana Pr, 2004.

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21

Vaccines and Autoimmunity. Wiley & Sons, Incorporated, John, 2015.

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22

Shoenfeld, Yehuda, Nancy Agmon-Levin, and Lucija Tomljenovic. Vaccines and Autoimmunity. Wiley & Sons, Incorporated, John, 2015.

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23

Shoenfeld, Yehuda, Nancy Agmon-Levin, and Lucija Tomljenovic. Vaccines and Autoimmunity. Wiley & Sons, Incorporated, John, 2015.

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24

Flower, Darren R., and Yvonne Perrie. Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines. Springer, 2012.

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25

Immunomic Discovery Of Adjuvants And Candidate Subunit Vaccines. Springer, 2012.

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26

Singh, Manmohan, and Indresh K. Srivastava. Development of Vaccines: From Discovery to Clinical Testing. Wiley & Sons, Incorporated, John, 2012.

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27

Flower, Darren R., and Yvonne Perrie. Immunomic Discovery of Adjuvants and Candidate Subunit Vaccines. Springer, 2015.

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28

Sklar, Larry A., ed. Flow Cytometry for Biotechnology. Oxford University Press, 2005. http://dx.doi.org/10.1093/oso/9780195183146.001.0001.

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Flow cytometry is a sensitive and quantitative platform for the measurement of particle fluorescence. In flow cytometry, the particles in a sample flow in single file through a focused laser beam at rates of hundreds to thousands of particles per second. During the time each particle is in the laser beam, on the order of ten microseconds, one or more fluorescent dyes associated with that particle are excited. The fluorescence emitted from each particle is collected through a microscope objective, spectrally filtered, and detected with photomultiplier tubes. Flow cytometry is uniquely capable of the precise and quantitative molecular analysis of genomic sequence information, interactions between purified biomolecules and cellular function. Combined with automated sample handling for increased sample throughput, these features make flow cytometry a versatile platform with applications at many stages of drug discovery. Traditionally, the particles studied are cells, especially blood cells; flow cytometry is used extensively in immunology. This volume shows how flow cytometry is integrated into modern biotechnology, dealing with issues of throughput, content, sensitivity, and high throughput informatics with applications in genomics, proteomics and protein-protein interactions, drug discovery, vaccine development, plant and reproductive biology, pharmacology and toxicology, cell-cell interactions and protein engineering.
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29

Vaccines: Preventing Disease (The Encyclopedia of Discovery and Invention). Lucent Books, 1992.

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30

Казачинская, Е. И. ВИРУС ДЕНГЕ. Академическое изд-во «Гео», 2021. http://dx.doi.org/10.21782/b978-5-6043022-6-2.

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The review is devoted to the analysis of literature data on the history research of dengue fever, the discovery of the etiological infectious agent of this disease-dengue virus and its serotypes. A taxonomic overview of the }lavivirus family, genome organization, structure and function of viral proteins, mosquito species-viral vectors and virus transmission cycles, theories of its origin are presented. As well as the evolution, characteristics and epidemiology of viral serotypes, cellular receptors for dengue virus penetration, pathogenicity for human and factors for the development of severe disease, induced immunity, applied methods and markers for diagnosis, principles of disease treatment and drug development (more information about monoclonal antibodies-potential therapeutic drugs), vaccine options and their effectiveness are considered. The book is intended for students, graduate students, employees of research institutions and universities, as well as doctors involved in the study of }laviviruses and the problem of differential diagnosis of flavivirus infections.
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31

Ranking Vaccines A Prioritization Framework. National Academies Press, 2012.

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32

Rowland, Della. The speckled monster: Or how the smallpox vaccine was discovered (Leveled books). McGraw-Hill School division, 1999.

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33

Barrett, Alan D. T., and Gregg N. Milligan. Vaccinology: An Essential Guide. Wiley & Sons, Incorporated, John, 2014.

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34

Barrett, Alan D. T., and Gregg N. Milligan. Vaccinology: An Essential Guide. Wiley & Sons, Incorporated, John, 2014.

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35

Vaccinology: An Essential Guide. Wiley-Blackwell, 2015.

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36

Kirchner, Jeffrey T. The Origin, Evolution, and Epidemiology of HIV-1 and HIV-2. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190493097.003.0002.

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HIV-1 originated in the early 1920s in southern Cameroon and the Democratic Republic of Congo. From Africa, HIV rapidly spread in the late 1960s to the Caribbean and then the United States, Europe, and other areas of the world, leading to the global AIDS pandemic. Both HIV-1 and HIV-2 descended genetically from Simian immunodeficiency virus via cross-species transmission. HIV-1 group M was the first lineage discovered and represents the pandemic form of the virus. Group M consists of nine viral subtypes (A–K), has a widespread distribution, and accounts for approximately 95% of all HIV-1 infections. HIV-2 was not discovered until 1986 and makes up approximately 3% of cases worldwide. It is found mainly in West Africa. The genetic diversity of HIV does not appear to significantly affect viral response to antiretroviral therapy. However, viral diversity continues to present challenges for the development of an effective HIV vaccine.
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37

Torrence, Paul F. Combating the Threat of Pandemic Influenza: Drug Discovery Approaches. Wiley & Sons, Incorporated, John, 2007.

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38

F, Torrence Paul, ed. Combating the threat of pandemic influenza: Drug discovery approaches. Hoboken, N.J: John Wiley & Sons, 2008.

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39

Iversen, Les. 1. History. Oxford University Press, 2016. http://dx.doi.org/10.1093/actrade/9780198745792.003.0001.

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‘History’ outlines the knowledge and use of drugs through the ages. Early written records of medicinal drugs are known to have existed in a range of ancient cultures, including the Greek, Egyptian, Indian, and Chinese civilizations. In the medieval world, both Arabic and European countries studied drugs. Scientific investigation came about with the Renaissance, but medicine did not become truly scientific until the 19th century, when antiseptics, vaccines, and anaesthetics were discovered and produced. Drugs have also been used recreationally and ceremonially for millennia, whether naturally occurring (cannabis or opium), or artificially synthesized (LSD or ecstasy). Both medicinal and recreational drugs have become major, worldwide industries.
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40

The woman who cured cancer: The story of cancer pioneer Virginia Livingston-Wheeler, M.D., and the discovery of the cancer-causing microbe. Basic Health Publications, Incorporated, 2014.

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41

Simpson, A., E. Aarons, and R. Hewson. Marburg and Ebola viruses. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198570028.003.0038.

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Infection with Marburg and Ebola viruses cause haemorrhagic fevers that are characterized by organ malfunction, bleeding complications, and high mortality. The viruses are members of the family Filoviridae, a group of membrane-enveloped filamentous RNA viruses. Five distinct species of the genus Ebolavirus have been reported; the genus Marburgvirus contains only one species. Both Marburg and Ebola virus diseases are zoonotic infections whose primary hosts are thought to be bats. The initial human infection is acquired from wildlife and subsequent person-to-person spread propagates the outbreak until it is brought under control. Ebola and Marburg viruses are classified as hazard or risk group 4 pathogens because of the very high case fatality rates observed for Ebola and Marburg virus diseases, the frequency of person-to-person transmission and community spread, and the lack of an approved vaccine or antiviral therapy. This mandates that infectious materials are handled and studied in maximum containment laboratory facilities. Epidemics have occurred sporadically since the discovery of Marburg in 1967 and Ebola virus in 1976. While some of these outbreaks have been relatively large, infecting a few hundreds of individuals, they have generally occurred in rural settings and have been controlled relatively easily. However, the 2013–2016 epidemic of Ebola virus disease in West Africa was different, representing the first emergence of the Zaire species of Ebola in a high-density urban location. Consequently, this has been the largest recorded filovirus outbreak in both the number of people infected and the range of geographical spread. Many of the reported and confirmed cases were among people living in high-density and impoverished urban environments. The chapter summarizes the most up-to-date taxonomic status of the family Filoviridae. It focuses on Marburg and Ebola viruses in a historical context, culminating in the 2013–2016 outbreak of Ebola virus in West Africa. Virus biology of the most well-studied member is described, with details of the viral genome and the protein machinery necessary to propagate viruses at the molecular and cellular level. This information is used to build a wider-scale virus–host perspective with detail on the pathology and pathogenesis of Ebola virus disease. The consequences of cell infection are examined, together with our current understanding of the immune response to Ebola virus, leading to a broader description of the clinical features of disease. The chapter closes by drawing information together in a section on diagnosis, ecology, prevention, and control.
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42

F, Ballenger Jesse, ed. Treating dementia: Do we have a pill for it? Baltimore: Johns Hopkins University Press, 2009.

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43

F, Ballenger Jesse, ed. Drugs in the treatment of dementia: Critical questions. Baltimore: Johns Hopkins University Press, 2009.

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44

Essential facts about Covid-19: the disease, the responses, and an uncertain future. For South African learners, teachers, and the general public. Academy of Science of South Africa (ASSAf), 2021. http://dx.doi.org/10.17159/assaf.2021/0072.

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The first cases of a new coronavirus (SARS-CoV-2) were identified toward the end of 2019 in Wuhan, China. Over the following months, this virus spread to everywhere in the world. By now no country has been spared the devastation from the loss of lives from the disease (Covid-19) and the economic and social impacts of responses to mitigate the impact of the virus. Our lives in South Africa have been turned upside down as we try to make the best of this bad situation. The 2020 school year was disrupted with closure and then reopening in a phased approach, as stipulated by the Department of Education. This booklet is a collective effort by academics who are Members of the Academy of Science of South Africa (ASSAf) and other invited scholars to help you appreciate some of the basic scientific facts that you need to know in order to understand the present crisis and the various options available to respond to it. We emphasise that the threat of infectious diseases is not an entirely new phenomenon that has sprung onto the stage out of nowhere. Infectious diseases and pandemics have been with us for centuries, in fact much longer. Scientists have warned us for years of the need to prepare for the next pandemic. Progress in medicine in the course of the 20th century has been formidable. Childhood mortality has greatly decreased almost everywhere in the world, thanks mainly, but not only, to the many vaccines that have been developed. Effective drugs now exist for many deadly diseases for which there were once no cures. For many of us, this progress has generated a false sense of security. It has caused us to believe that the likes of the 1918 ‘Spanish flu’ pandemic, which caused some 50 million deaths around the world within a span of a few months, could not be repeated in some form in today’s modern world. The Covid-19 pandemic reminds us that as new cures for old diseases are discovered, new diseases come along for which we are unprepared. And every hundred or so years one of these diseases wreaks havoc on the world and interferes severely with our usual ways of going about our lives. Today’s world has become increasingly interconnected and interdependent, through trade, migrations, and rapid air travel. This globalisation makes it easier for epidemics to spread, somewhat offsetting the power of modern medicine. In this booklet we have endeavoured to provide an historical perspective, and to enrich your knowledge with some of the basics of medicine, viruses, and epidemiology. Beyond the immediate Covid-19 crisis, South Africa faces a number of other major health challenges: highly unequal access to quality healthcare, widespread tuberculosis, HIV infection causing AIDS, a high prevalence of mental illness, and a low life expectancy, compared to what is possible with today’s medicine. It is essential that you, as young people, also learn about the nature of these new challenges, so that you may contribute to finding future solutions.
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