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Relevant bibliographies by topics / Vaccine development / Dissertations / Theses

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Dissertations / Theses on the topic 'Vaccine development'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Da, Silva Pissarra Joana. "Development of a multi-epitope peptide vaccine against human leishmaniases." Thesis, Montpellier, 2019. http://www.theses.fr/2019MONTT013/document.

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La leishmaniose est une maladie tropicale négligée à transmission vectorielle qui est endémique dans 98 pays dont les plus pauvres. Vingt espèces de Leishmania sont capables d’établir une infection intracellulaire au sein des macrophages humains, provoquant différentes manifestations cliniques. Le développement d'un vaccin contre les leishmanioses est étayé par des preuves d'immunité naturelle contre l'infection, induite par une réponse à médiation cellulaire de type Th1 dominante associée à la production d'IFN-γ, d'IL-2 et de TNF-α par des cellules T polyfonctionnelles TCD4+ et TCD8+, conduis

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2

LeÌtourneau, Sven C. "HIV-1 vaccine development." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442825.

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3

Thompson, Fiona Mary. "Malaria immunology and vaccine development." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/67626/.

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This thesis describes work undertaken by the author at the University of Oxford. It begins by providing an introduction to malaria infection and pathophysiology, and a review of the latest attempts to produce an effective malaria vaccine. It goes on to describe the rationale behind the vaccines developed by the University of Oxford and others. A brief introduction to the process of planning and carrying out clinical trials of vaccines is then provided, and is followed by chapters describing two clinical trials, designed to test the safety, immunogenicity and then efficacy of candidate malaria

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4

Busch, Marc Gregory. "Evaluation of different SIV plasmid DNA vaccines : a model for HIV vaccine development /." For electronic version search Digital dissertations database. Restricted to UC campuses. Access is free to UC campus dissertations, 2004. http://uclibs.org/PID/11984.

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5

Brune, Karl Dietrich. "Engineering modular platforms for rapid vaccine development." Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:41d57165-6e7c-4ca7-8025-b5ec31794c8c.

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Vaccines have saved more lives than any other medical intervention. Recombinant vaccines provide unmatched safety profiles, but at the expense of reduced immunogenicity. Virus-like particles (VLPs) resemble viruses in size, shape and repetitive arrangement but are devoid of pathogenic genetic material and therefore safe. Poor immunogens can be rendered immunogenic by display on VLPs. Successfully decorating VLPs is still a major challenge. Genetic fusion or chemical modification is often time-consuming and can lead to misassembly or misfolding, which obstructs generation of the desired immune

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6

Flock, Margareta. "Development of a vaccine against strangles /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-500-3/.

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7

Poobalane, Saravanane. "Aeromonas hydrophila vaccine development using immunoproteomics." Thesis, University of Stirling, 2007. http://hdl.handle.net/1893/195.

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Aeromonas hydrophila is an opportunistic pathogen that causes a wide range of symptoms and diseases in fish. Development of a commercial vaccine has been problematic due to the heterogenicity between isolates of A. hydrophila. A new approach using immunoproteomics was used in this study to try to develop a vaccine that would protect against a wide range of A. hydrophila strains. The virulence of 14 isolates of A. hydrophila from different geographical regions was determined in common carp (Cyprinus carpio) indicating that 6 isolates were virulent, while 8 isolates were avirulent. Expression of

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8

Beard, Jody. "Early development of a hookworm vaccine." Thesis, University of Nottingham, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.416306.

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9

Aguilar, Roberto III. "Development of A Testicular Cancer Vaccine." Cleveland State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=csu1461270103.

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10

Tarcha, Eric J. "Application of Immunoproteomics and Bioinformatics to coccidioidomycosis Vaccinology." University of Toledo Health Science Campus / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=mco1154441973.

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11

Maas, Alexander. "DIVA vaccine development against Actinobacillus pleuropneumoniae infection." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=983732574.

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12

Hota-Mitchell, Sheela. "Molecular approaches to vaccine development against schistosomiasis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0004/NQ32311.pdf.

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13

Leung, Beatrice Pui See. "Development of a DNA vaccine against melioidosis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0018/MQ55225.pdf.

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14

Leduc, Isabelle. "Strain typing and vaccine development for chancroid." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/NQ66163.pdf.

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15

Al, Yaghchi C. "Development of virus-infected cancer cell vaccine." Thesis, Queen Mary, University of London, 2016. http://qmro.qmul.ac.uk/xmlui/handle/123456789/18408.

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Oncolytic viruses can be genetically modified to limit their replication in normal cells rendering them a cancer specific treatment. In addition, they can induce a 'danger signal' in the form of pathogen- and damage-associated molecular patterns leading to anti-tumour immunity. Furthermore, they can be armed with various immunomodulatory molecules to further enhance anti-tumour immunity. In this project I aim to exploit these qualities to develop a translatable cancer vaccine. Virus-infected cancer cells were injected subcutaneously in a prime/boost regimen. Dying cancer cells will release the

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16

Hussain, Muattaz Yassein. "Studies on development of a Leishmanial vaccine." Thesis, University of Strathclyde, 2017. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=29430.

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Leishmaniasis is a disease caused by infection with the obligate intracellular parasite of the genus Leishmania. Leishmaniasis is a public health problem; it is estimated that approximately 12-15 million people worldwide are infected. An estimated 1.5-2 million new cases occur each year, 350 million people are at risk of infection, and it causes 70000 deaths per year. Therefore, development of a vaccine to prevent infection is required. The overall aim of this study was to develop a vaccine to protect against Leishmania infection using live nonpathogenic L. tarentolae transfected with gamma gl

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17

Gebril, Ayman Mohamed. "Development of a mucosal vaccine delivery system." Thesis, University of Strathclyde, 2013. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=24878.

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18

Ramamoorthy, Sheela. "Approaches towards vaccine development against Neospora caninum." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/28054.

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Neospora caninum is an apicomplexan parasite that causes neuromuscular paralysis in dogs and abortions in cattle. N. caninum is responsible for losses of several million dollars to the dairy and beef industries in several parts of the world. The key players in the host immune response to N. caninum include CD4+ T cells, the Th1 cytokines IL-12, Interferon gamma and IgG2a isotype antibodies. There are currently no chemotherapeutic agents that are effective against adult cattle neosporosis. A commercially available, inactivated vaccine induces the undesirable Th2 type of immunity against N. cani

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19

Cash, Devin R. "DRUG AND VACCINE DEVELOPMENT FOR NEISSERIA GONORRHOEAEA." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4093.

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Neisseria gonorrhoeae, the causative agent of the STI gonorrhea, is not preventable by vaccination and is rapidly developing resistance to antibiotics. One important strategy for gonococcal survival in the host is iron acquisition in the face of nutritional immunity. To overcome iron limitation, the gonococcus expresses TonB dependent transporters (TdTs), outer membrane proteins that facilitate nutrient acquisition. Of the TdTs, the transferrin (Tf), lactoferrin (Lf), and hemoglobin (Hb) receptors hijack iron directly from host proteins, and studies have already shown that the Tf receptor is e

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20

Mughal, Muhammad Kashif. "Development of Pneumolysin as a vaccine candidate." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5151/.

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More than 90 serotypes of Streptococcus pneumoniae are responsible for causing a number of invasive and non-invasive diseases in humans. To combat this pathogen there are two types of vaccines available namely pneumococcal polysaccharide vaccine (PPV) and pneumococcal conjugate vaccine (PCV). Although these vaccines have reduced the incidence and prevalence of pneumococcal diseases yet these vaccines are unable to curb the disease and have some potential drawbacks. The problems associated with PPV is inability to mount appropriate immune response in young children (<2 years) of age and with PC

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21

Woodberry, Tonia. "Development of a mucosal HIV polytope vaccine /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16255.pdf.

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22

Bláha, BenjaminA F. "Platform processes for vaccine production : development of a universal influenza vaccine using Pichia pastoris." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10047467/.

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Influenza virus remains a familiar threat to public health and continues to challenge the scientific community. Most challenging is responding to the evolutionary adaptability of influenza virus, which often hinders effective prevention or treatment. Furthermore, current production methods are logistically and technically inadequate to cope with pandemic surges, leaving a considerable number of individuals unprotected. Tandem Core Virus-Like Particles (VLPs), expressed in Pichia pastoris, offer an exciting proposition to create a platform process for a universal influenza vaccine. However, as

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23

Hand, Nicholas. "Development of a Recombinant Attenuated Salmonella Cancer Vaccine." Thesis, The George Washington University, 2017. http://pqdtopen.proquest.com/#viewpdf?dispub=10635177.

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<p>New treatments for neuroblastoma are desperately needed; high-risk neuroblastoma patients have a less than 50% five-year survival rate despite intensive treatment. The greatest impact on improving survival rates for cancer patients in recent years is the result of a number of immunotherapeutic approaches. A proportion of high-risk neuroblastoma patients undergo spontaneous regression, possibly mediated by the immune system, indicating the potential of immunotherapies targeting neuroblastoma-associated antigens. Recombinant attenuated Salmonella vaccines (RASV) are cost-effective and have s

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24

Smith, Claire Mary. "Development of new vaccine strategies against Streptocarpus pneumoniae." Thesis, University of Leicester, 2005. http://hdl.handle.net/2381/30506.

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In this thesis I have shown that peptide mimotopes of both serotype 6B and 9V pneumococcal polysaccharide, following vaccination, can induce specific and anti-CPS antibodies and can protect mice against developing pneumococcal disease. This was achieved using previously described monoclonal antibodies (mAb) directed against the capsular polysaccharide of S. pneumoniae serotype 6B and 9V. These mAbs were shown to protect mice in passive immunisation experiments, and were then used to screen phage-displayed peptide libraries. In total four peptide mimics of serotype 9V pneumococcal polysaccharid

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25

Clark, Douglas Alexander Stuart. "Haemonchus contortus and hookworms : parallels in vaccine development." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437717.

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26

Moynihan, Jennifer Susan. "The development of a synthetic hepatitis B vaccine." Thesis, Royal Veterinary College (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392197.

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27

Mukhopadhyay, Tarit K. "Rapid vaccine development using a micro-scale platform." Thesis, University College London (University of London), 2008. http://discovery.ucl.ac.uk/1444233/.

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Vaccine research and development is becoming increasingly important because of the potential to create a blockbuster drug, such as Prevnar. However, the development pipeline continues to be a limiting factor in commercialising a vaccine. In this thesis a micro-scale platform is created to mimic the key features of a unit operation so that it is possible to calculate the impact of a commercial manufacturing process using this scaled down platform. Two model vaccines were applied to the micro-scale platform, a new Meningitis serogroup B vaccine based on the outer membrane vesicle proteins of Nei

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28

Vieira, Coutinho Abreu Gomes Iliano. "Molecular aspects of sand-fly-based vaccine development." Diss., Kansas State University, 2011. http://hdl.handle.net/2097/9224.

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Doctor of Philosophy<br>Department of Entomology<br>Marcelo Ramalho-Ortigao<br>The emergence and reemergence of vector-borne diseases pose significant threats to humans and other animals worldwide. Although vector control relies mostly on insecticides, the emergence of insecticide resistance urges for the development of new strategies to control the spread of such diseases. For sand fly-transmitted leishmaniasis, Transmission Blocking Vaccines (TBV) may constitute a feasible strategy to impair Leishmania transmission from infected to uninfected vertebrate hosts. Moreover, sand fly saliva-based

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29

Ahmadi, Fard Ala. "Ebola hemorrhagic fever: outbreaks, modeling, and vaccine development." Kansas State University, 2016. http://hdl.handle.net/2097/32649.

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Master of Science<br>Department of Biological & Agricultural Engineering<br>Caterina M. Scoglio<br>Lisa R. Wilken<br>Between the years 2014 and 2015, the world experienced a catastrophic outbreak of Ebola virus, which killed over 26,000 people. Several authorities and organizations actively participated in fighting the epidemic. Infectious disease modelers proved to be invaluable towards this goal. This report provides a background on the Ebola epidemic in West Africa and reviews the biological features of the Ebola virus. Moreover, this report applies a new model for Ebola propagation using d

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30

Duvenage, Lucian. "Beak and feather disease virus candidate vaccine development." Master's thesis, University of Cape Town, 2012. http://hdl.handle.net/11427/12785.

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Includes bibliographical references.<br>[Fix supervisors field.] Psittacine beak and feather disease, caused by a circovirus known as beak and feather disease virus (BFDV), is a threat to both wild and captive psittacine species. There is currently no vaccine against BFDV and safe and affordable vaccine candidates are needed to alleviate the disease burden caused by this virus. Production of the BFDV's major antigenic determinant, the capsid protein (CP), in the inexpensive and highly scalable plant expression system, could satisfy these requirements as a potential subunit vaccine. In this wor

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31

Grieves, Jessica Louise. "Respiratory Syncytial Virus: Rodent Models and Vaccine Development." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1354147313.

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32

Coull, Jason J. "A molecular biology strategy for ectoparasite vaccine development." Thesis, University of Aberdeen, 1997. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602286.

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33

De, Sai Lata. "Chemically Treated Malaria Parasites as a Multimodal System for Vaccine Development." Thesis, Griffith University, 2016. http://hdl.handle.net/10072/367793.

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Current measures to control malaria are becoming unreliable due to the emergence of parasite and vector resistance. Therefore, development of a safe and effective vaccine is essential for the eventual eradication of malaria. Challenges that have hindered malaria vaccine research include antigenic polymorphism, reproducing correlates of protection from preclinical to clinical studies and the paucity of challenge models to test vaccine efficacy. Altering the virulence of the whole parasite using genetic manipulation, irradiation or chemical treatment has been used as an alternative vaccine strat

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34

Okay, Sezer. "Development Of Recombinant Vaccines Composed Of Plpe And Omph From Pasteurella Multocida A:3." Phd thesis, METU, 2011. http://etd.lib.metu.edu.tr/upload/12613980/index.pdf.

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Pasteurella multocida serotype A:3 is a gram-negative bacterial pathogen which is one of the causative agents of shipping fever in cattle. In this study, ompH and two fragments of plpE gene (plpEN and plpEC) were cloned from the genomic DNA of P. multocida P-1062 (ATCC 15743, serotype A:3) and plpEN-ompH and plpEC-ompH fusions were constructed. In vitro expression of the genes was shown in HEK-293 cells. Later, full-length plpE gene was cloned and the recombinant proteins were expressed in E. coli and purified. Three DNA vaccine formulations, namely pCMV-ompH, pCMV-plpEN-ompH and pCMV-plpEC-om

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35

Masterson, W. J. "Studies on the epitopes of the surface coat glycoprotein of a variant of Trypanosoma brucei brucei." Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383834.

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36

Whyte, Paul. "Identification and characterisation of protective B cell epitopes on the fusion protein of respiratory syncytial virus." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.241353.

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37

Beesley, Katrina M. "Expression of HBcAg fusion proteins in yeast and an investigation of their immunological properties." Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.292342.

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38

Selke, Martin. "Development of a DIVA vaccine against Salmonella Typhimurium infection." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=983732760.

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39

Huijbers, Elisabeth J. M. "Development of a Cancer Vaccine Targeting Tumor Blood Vessels." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-170887.

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A treatment strategy for cancer is the suppression of tumor growth by directing an immune response to the tumor vessels, which will destroy the tissue. In this thesis we describe the development of a vaccine that targets antigens expressed around angiogenic vasculature in most solid tumors. These antigens are alternative spliced extra domains of glycoproteins present in the extracellular matrix; e.g. the extra domain-B (ED-B) and extra domain-A (ED-A) of fibronectin and the C-domain of tenascin-C (TNCC). We show that it is possible to break self-tolerance and induce a strong antibody response

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40

Guan, Xin. "Development of DNA vaccine-based anti-tumor immunotherapeutic system." 京都大学 (Kyoto University), 2010. http://hdl.handle.net/2433/120528.

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41

Stell, Anneliese Jane. "Development of a DNA vaccine for canine malignant melanoma." Thesis, Royal Veterinary College (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502377.

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42

Brown, Alan Peter. "Necator americanus characterisation of secreted proteinases and vaccine development." Thesis, Nottingham Trent University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314108.

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43

Naylor, Clive John. "Studies on avian pneumoviruses including development of a vaccine." Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385304.

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44

Hacking, G. N. V. "Novel approaches towards the development of an HIV vaccine." Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308246.

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45

Suzuki, Saori. "Basic research for the development of hepatitis C vaccine." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215372.

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Contents of the present thesis were published in the following articles. 1. Suzuki S, Mori K, Higashino A, Iwasaki Y, Yasutomi Y, Maki N, Akari H. 2016. Persistent replication of a hepatitis C virus genotype 1b-based chimeric clone carrying E1, E2 and p6 regions from GB virus B in a New World monkey. Microbiol Immunol 60:26-34. Copyright © 1999-2016 John Wiley & Sons, Inc.2. Yoshida T, Suzuki S, Iwasaki Y, Kaneko A, Saito A, Enomoto Y, Higashino A, Watanabe A, Suzuki J, Inoue K, Kuroda T, Takada M, Ito R, Ito M, Akari H. 2013. Efficient in vivo depletion of CD8+ T lymphocytes in common marmose

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46

Ramirez, Paredes J. G. "The fish pathogen Francisella orientalis : characterisation and vaccine development." Thesis, University of Stirling, 2015. http://hdl.handle.net/1893/21822.

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Piscine francisellosis in an infectious emerging bacterial disease that affects several marine and fresh water fish species worldwide, including farmed salmon, wild and farmed cod, farmed tilapia and several ornamental species, for which no commercial treatment or vaccine exists. During 2011 and the first semester of 2012, chronic episodes of moderate to high levels of mortality with nonspecific clinical signs, and widespread multifocal white nodules as the most consistent gross pathological lesion were experienced by farmed tilapia fingerlings at two different locations in Northern Europe. In

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47

Burnett, Mary Susan. "Development of a live vaccine for human immunodeficiency virus /." Digital version accessible at:, 1997. http://wwwlib.umi.com/cr/utexas/main.

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Chen, Mei-Jane, and 陳美臻. "Development of anti-gastrin vaccine." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/53093197054921760488.

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碩士<br>國立陽明大學<br>生物化學研究所<br>91<br>Abstract Gastrin, produced by G cells in the gastric antrum, has been identified as the circulation hormone responsible for stimulation of acid secretion from the parietal cell. It also has an important trophic of growth —promoting influence on the gastric mucosa. Recent studies showed that excessive secretion of gastrin promotes the growth of some gastrointestinal cancers, as well as non-gastrointenstinal cancers, including pancreatic carcinoma, small cell lung cancer, and renal tumors. Peptic ulcers caused by increased stomach acid which is also de

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Wang, Kuan-Kai, and 王冠凱. "Development of PEDV subunit vaccine." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/49526957823552356772.

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碩士<br>國立屏東科技大學<br>動物疫苗科技研究所<br>103<br>Porcine epidemic diarrhea (PED) is caused by porcine epidemic diarrhea virus (PEDV). It would infect all age of swines, and be characterized by severe diarrhea, vomiting, and dehydration. PED was first reported in England in 1971 and the virus was first identified in Belgium. The virus belongs to the genus Alphacoronavirus, family Coronaviridae. It`s genome is single-stranded, positive-sense RNA which is contain 28 kb in length. The genome can translate four structure proteins, i.e. spike protein (S, 180-220kDa), membrane protein (M, 27-32kDa), envelope pr

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Chen, Shin-Han, and 陳信翰. "Development of PRRS subunit vaccine." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/33765741338798050188.

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碩士<br>國立屏東科技大學<br>動物疫苗科技研究所<br>103<br>Porcine reproductive and respiratory syndrome virus (PRRSV) is the most economically significant disease of swine worldwide. Typical immunological features in PRRSV-infected pigs are delayed onset and low level of neutralizing antibodies and a weak cell-mediated immune response. The disease mainly causes premature delivery, miscarriage, stillbirth, mummified fetuses, severe pneumonia, edema and conjunctivitis in pigs. PRRSV belongs to the family Arteriviridae in the order Nidovirales, a family of positive-sense, single stranded linear RNA viruses. The geno

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