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Dissertations / Theses on the topic 'V-ATPase'

Author: Grafiati

Published: 4 June 2021

Last updated: 9 March 2023

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1

Schempp, Christina Maria. "The V-ATPase inhibitor archazolid." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-168586.

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Fighting metastasis is a major challenge in cancer therapy and novel therapeutic targets and drugs are highly appreciated. Resistance of invasive cells to anoikis, a particular type of apoptosis induced by loss of cell-extracellular matrix (ECM) contact, is a major prerequisite for their metastatic spread. Inducing anoikis in metastatic cancer cells is therefore a promising therapeutic approach. The vacuolar H+-ATPase (V-ATPase), a proton pump located at the membrane of acidic organelles, has recently come to focus as an anti-metastatic cancer target. As V-ATPase inhibitors have shown to prev

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2

Firmino, Kelly Cristina Silva. "Processos osmorregulatórios no caranguejo Dilocarcinus pagei (Decapoda, Trichodactylidae), um antigo invasor da água doce: estudo das atividades (Na,K)-ATPase e V-ATPase branquiais." Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/59/59138/tde-19082009-112806/.

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Os crustáceos são originariamente marinhos; ao longo da evolução, diversas espécies invadiram ambientes de salinidades menores, chegando à água doce. A capacidade dos crustáceos colonizarem com sucesso o ambiente dulcícola depende do desenvolvimento de mecanismos eficientes de hiperosmorregulação. A osmolalidade e a composição iônica da hemolinfa de um crustáceo, em meios diluídos, refletem o equilíbrio dinâmico entre a perda de íons por difusão e pela urina e sua reabsorção do meio externo, através das brânquias. A (Na,K)-ATPase branquial desempenha um papel chave no processo de captura de Na

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3

Reineke, Stephan. "Topologie und Regulation der Manduca sexta V-ATPase." Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=970381719.

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4

Miles, Anna Louise. "V-ATPase regulation of Hypoxia Inducible transcription Factors." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/283217.

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Metazoans have evolved conserved mechanisms to promote cell survival under low oxygen tensions by initiating a transcriptional cascade centered on the action of Hypoxia Inducible transcription Factors (HIFs). In aerobic conditions, HIFs are inactivated by ubiquitin-proteasome-mediated degradation of their a subunit, which is dependent on prolyl hydroxylation by 2-oxoglutarate (2-OG) and Fe(II)-dependent prolyl hydroxylases (PHDs). In hypoxia, HIF-$\alpha$ is no longer hydroxylated and is therefore stabilised, activating a global transcriptional response to ensure cell survival. Interestingly,

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5

Voß, Martin. "Regulation der vakuolären H(+)-ATPase durch reversible Proteinphosphorylierung." Phd thesis, Universität Potsdam, 2008. http://opus.kobv.de/ubp/volltexte/2008/1961/.

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Die vakuoläre Protonen-ATPase, kurz V-ATPase, ist ein multimerer Enzymkomplex, der in fast jeder eukaryotischen Zelle zu finden ist und den aktiven elektrogenen Transport von Protonen über Membranen katalysiert. Die Aktivität der V-ATPase ist essentiell für eine Vielzahl physiologischer Prozesse. Ein grundlegender Mechanismus zur Regulation der V-ATPase-Aktivität ist die reversible Dissoziation des Holoenzyms in den integralen VO-Komplex, der als Protonenkanal dient, und den cytosolischen V1-Komplex, der ATP hydrolysiert und somit den Protonentransport energetisiert. Die Untereinheit C, die im

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6

Owegi, Margaret. "Site-directed mutagenesis of yeast V-ATPase subunit d." Virtual Press, 2005. http://liblink.bsu.edu/uhtbin/catkey/1319550.

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V-ATPases are enzymes found in all eukaryotic cells. They are organized into a peripheral membrane complex (V1) and an integral membrane complex (V0). VI is responsible for ATP hydrolysis and generates the energy used by Vo to pump protons from the cytosol into the vacuole. Subunit d is a component of Vo possibly located at the interface between V 1 and V. in the V-ATPase complex. We hypothesize that subunit d could be involved in the structural and functional coupling of VI and Vo. This was tested by generating point mutations along the open reading frame of subunit d from yeast. The mutation

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7

Gerle, Christoph. "Two-dimensional crystallization of intact Thermus thermophilus V-ATPase." 京都大学 (Kyoto University), 2006. http://hdl.handle.net/2433/144145.

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8

Wiedmann, Romina Madeleine. "Anticancer effects of the V-ATPase inhibitor Archazolid B." Diss., Ludwig-Maximilians-Universität München, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-139515.

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9

Cheng, Tak Sum. "Molecular identification and characterization of novel osteoclast V-ATPase subunits." University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0068.

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[Truncated abstract] Osteoclasts are multinucleated giant cells responsible for the resorption of the mineralized bone matrix during the process of bone remodelling. During activation towards bone resorption, polarization of the osteoclast results in the formation of a unique plasma membrane, the ruffled border, the actual resorptive organelle of the osteoclast. Through this domain protons are actively pumped into the resorption lacuna creating an acidic microenvironment that favours the dissolution of the mineralized bone matrix. The polarised secretion of protons is carried out by the action

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10

STORACI, ALESSANDRA MARIA. "FURTHER INSIGHT INTO V-ATPASE ROLE IN GLIOMA STEM CELLS." Doctoral thesis, Università degli Studi di Milano, 2020. http://hdl.handle.net/2434/703269.

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V-ATPase is a proton pump mainly localized on lysosomes and on plasma membrane of specialized cells. It is responsible of proton translocation and acidification of intra- and extra-cellular environment. Our group demonstrated that the over-expression of the subunit G1 (V1G1) is involved in the maintenance of the stem cell niche in glioblastoma (GBM) and correlates with poor prognosis in GBM patients. In this work we aimed to elucidate the role of V-ATPase in GBM stem cells from a functional perspective. We demonstrated that neurospheres (NS) with higher levels of V1G1 subunit (High-V1G1), comp

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11

Huss, Markus. "Struktur, Funktion und Regulation der Plasmamembran-V-ATPase von Manduca sexta." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963587560.

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12

Darley, Catherine P. "The physiological roles of the vacuolar proton-pumping pyrophosphatase." Thesis, University of York, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337633.

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13

Schewe, Bettina. "Räumliche und zeitliche Aspekte der intrazellulären pH-Regulation in Epithelien." Phd thesis, Universität Potsdam, 2008. http://opus.kobv.de/ubp/volltexte/2008/2687/.

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Die Speicheldrüsen der Schmeißfliege Calliphora vicina produzieren bei Stimulierung mit dem Neurohormon Serotonin (5-Hydroxytryptamine, 5-HT) einen KCl-reichen Primärspeichel. Der transepitheliale K+-Transport wird durch eine apikal lokalisierte vakuoläre H+-ATPase (V-ATPase) energetisiert. Stimulierung der Speicheldrüsen mit 5-HT aktiviert die apikale V-ATPase, die Protonen aus der Zelle in das Drüsenlumen transportiert. Trotz des auswärts gerichteten Protonentransportes führt die 5-HT-Stimulierung kurioserweise zu einer intrazellulären Ansäuerung. Die Ursachen dieser 5-HT-induzierten Ansäuer

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14

Tsiantis, Miltiades S. "Regulation of V-ATPase gene expression by ionic stress in higher plants." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337540.

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15

FORMICA, MIRIAM. "V-ATPASE AND AUTOPHAGY PREVENT GLIOMA GROWTH IN A DROSOPHILA MODEL SYSTEM." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/611790.

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Introduction: Glioblastoma (GBM), the most aggressive form of malignant gliomas, is an incurable tumor of the central nervous system which starts in glial cells, and rapidly diffuses through the brain. Surgical resection, radiotherapy and chemotherapy are the standard of care of GBM, improving the survival rate up to only 14-15 months. The high infiltrating nature of the tumor hampers surgical resection and tumoral cells often develop chemoresistance to the widely-used temozolomide (TMZ). Currently, a targeted therapy is not available. Therefore, the 5 years survival rate of these patients is

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16

RebouÃas, Deborah Moura. "Efeito do Ãcido abscÃsico nas bombas de prÃtons vacuolares e enzimas antioxidantes em Vigna unguiculata (L.) Walp." Universidade Federal do CearÃ, 2011. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5884.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>O Ãcido abscÃsico (ABA) Ã um fitohormÃnio que desempenha papÃis crÃticos na regulaÃÃo das respostas das plantas ao crescimento e desenvolvimento. O vacÃolo de plantas superiores Ã uma organela que ocupa a maior parte da cÃlula. A condiÃÃo de acidez Ã mantida por duas bombas de prÃtons distintas, V-ATPase e V-PPase. Sabe-se que estas bombas de prÃtons desempenham um papel essencial nas respostas das plantas Ãs mudanÃas ambientais. O gradiente eletroquÃmico promovido por essas enzimas Ã a forÃa motriz para o acÃmulo de Ãons e outro

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17

Dulac, Amina. "Identification and functional characterization of the neuronal protein VhaAC45L in Drosophila." Thesis, Université Paris sciences et lettres, 2021. http://www.theses.fr/2021UPSLS035.

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Les V-ATPases sont des complexes protéiques des cellules eucaryotes, hautement conservés, associés à la membrane de nombreux organites vésiculaires ou vacuolaires, dont la fonction est d’assurer un niveau approprié d'acidification. Si le mécanisme général du fonctionnement de cette pompe à protons a été bien étudié, on sait par contre relativement peu de choses sur les propriétés spécifiques de la V-ATPase neuronale. Dans les synapses, ce complexe est essentiel pour acidifier les vésicules synaptiques, permettant ainsi aux transporteurs des neurotransmetteurs de les remplir correctement. Notre

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18

Rizzo, Vincenzo Filippo. "Topologie und Relativbewegungen stielbildender Untereinheiten der V₁-ATPase aus der Tabakschwärmerraupe Manduca sexta." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=975231987.

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19

Voss, Martin, Wolfgang Blenau, Bernd Walz, and Otto Baumann. "V-ATPase deactivation in blowfly salivary glands is mediated by protein phosphatase 2C." Universität Potsdam, 2009. http://opus.kobv.de/ubp/texte_eingeschraenkt_verlag/2010/4436/.

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The activity of vacuolar H+-ATPase (V-ATPase) in the apical membrane of blowfly (Calliphora vicina) salivary glands is regulated by the neurohormone serotonin (5-HT). 5-HT induces, via protein kinase A, the phosphorylation of V-ATPase subunit C and the assembly of V-ATPase holoenzymes. The protein phosphatase responsible for the dephosphorylation of subunit C and V-ATPase inactivation is not as yet known. We show here that inhibitors of protein phosphatases PP1 and PP2A (tautomycin, ocadaic acid) and PP2B (cyclosporin A, FK-506) do not prevent V-ATPase deactivation and dephosphorylation of sub

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20

Gutmann, Daniel A. P. "Expression, purification and structural analysis of bacterial ABC transporters and v-atpase subunits." Thesis, Imperial College London, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486907.

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The aim of the project was to produce stable, soluble multidrug resistance (mdr) ABC. transporters and V-type ATPase subunits suitable for structural studies in order to gain insight into these two families of ATP metabolising membrane proteins. Mdr ABC transporters from a number 'of bacteria were successfully expressed. The best protein in terms of yield of pure protein (5mg.r1) was LmrA from LactococQus factis. Due to seripus aggregation this protein resisted all initial attempts at crystallisation. A novel method was developed, the Ultracentrifugation dispersity sedimentation (UDS) assay, t

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21

Wang, Qili. "Interaction entre la sous unité V0 de la V-ATPase et le facteur d'échange ARNO et son implication fonctionnelle dans l'exocytose régulée." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ049.

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Alors que s’accumulent des données épidémiologiques qui suggèrent une importance fondamentale des lipides de l’alimentation dans l’homéostasie cellulaire et le développement de nombreuses pathologies humaines, peu d’informations sur leurs fonctions spécifiques sont disponibles à ce jour. Ceci est particulièrement le cas pour la neurosecrétion qui dépend de la fusion d’organites vésiculaires avec la membrane plasmique. Des études récentes ont montré le rôle clé de la compartimentalisation lipidique au niveau des sites d’exocytose et par ailleurs validées la notion de lipides fusogéniques, comme

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22

Grünewald, Julian [Verfasser], and Matias [Akademischer Betreuer] Simons. "The Role of pH and the V-ATPase in Electric Field Guided Cell Migration." Freiburg : Universität, 2015. http://d-nb.info/1115861875/34.

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23

Cronan, Glen Emerson 1977. "Sorting and retention of the Golgi form of the V-type ATPase in yeast." Thesis, University of Oregon, 2011. http://hdl.handle.net/1794/11646.

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xii, 45 p. : col. ill.<br>Regulated acidification of intercellular organelles and vesicles is essential for many cellular processes, from basic metabolism and protein sorting to synapse function and developmental signaling. These diverse processes are driven by spatiotemporal regulation of the V-ATPase, the cellular H + -pump. In yeast and higher eukaryotes V-ATPase localization is directed by the 100-kDa "a" subunit, and many human diseases are linked to mutations in "a". Saccharomyces cerevisiae contains two "a" isoforms, VPH1 and STV1, with all other V-ATPase subunits encoded for by single

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24

Pimentel, André Coppe. "Fisiologia molecular digestiva da larva de Musca domestica." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-31012012-140549/.

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A digestão nos insetos ocorre no intestino médio de forma compartimentada. A digestão inicial dos polímeros ocorre no interior da membrana peritrófica. Os oligômeros resultantes difundem-se para o espaço luminal exterior à membrana peritrófica onde são atacados por outras enzimas. Na digestão final os dímeros resultantes são hidrolisados por enzimas imobilizadas na superfície do epitélio do intestino médio. Após o processo de digestão final os monômeros são absorvidos pelas células do epitélio intestinal. Os Díptera ditos superiores, incluindo a mosca doméstica, apresentam peculiaridades diges

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25

Finnigan, Gregory Charles 1983. "Evolution of the Vacuolar H+-ATPase Enzyme Complex." Thesis, University of Oregon, 2011. http://hdl.handle.net/1794/11535.

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xvii, 167 p. : ill. (some col.)<br>The vacuolar proton-translocating ATPase (V-ATPase) is a multisubunit enzyme complex responsible for acidification of cellular organelles. The V-ATPase hydrolyzes ATP to pump protons across membranes to create an electrochemical gradient. Acidification of vesicular compartments is critical in numerous biological processes including protein trafficking, endocytosis, and ion homeostasis; defects in V-ATPase function can also lead to human diseases. While the function of the V-ATPase enzyme is highly conserved across eukaryotes, the molecular architecture of thi

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26

Guo, Yiquan. "Cloning, characterisation and site-selected P-element mutagenesis of genes encoding V-ATPase in Drosophila." Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.320285.

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27

Wiedmann, Romina Madeleine [Verfasser], and Angelika [Akademischer Betreuer] Vollmar. "Anticancer effects of the V-ATPase inhibitor Archazolid B / Romina Madeleine Wiedmann. Betreuer: Angelika Vollmar." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2011. http://d-nb.info/1019479345/34.

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28

Neubert, Christoph [Verfasser], and Karin [Akademischer Betreuer] Schumacher. "Assembly and quality control of the V-ATPase in Arabidopsis / Christoph Neubert ; Betreuer: Karin Schumacher." Heidelberg : Universitätsbibliothek Heidelberg, 2012. http://d-nb.info/1177808889/34.

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29

Preedy, Amelia Louise. "Investigating the roles of the cardiomyocyte V- ATPase and NHE1, and their response to insulin stimulation." Thesis, University of Bath, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486848.

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The aims of this thesis were to investigate the effects of insulin on the cellular distribution and activity of the Na+/It exchanger (NHEI) and vacuolar proton pumps (VATPases) in cardiomyocytes and to evaluate their association with GLUT4 vesicles. To address these issues, a highly specific anti-NHEI antibody was raised, which enabled immunofluorescence, immunoprecipitation and co-immunoprecipitation studies into the effects of insulin on NHE1 distribution to be carried out. These studies provided evidence for an insulin-stimulated increase in NHEl at the plasma membrane and a decrease in int

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30

Chan, Yong. "Toward new inhibitors of the V-ATPase : identifying the factors which control forest productivity and biomass." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.440635.

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31

Bertolini, I. "EXOSOMES SIGNALLING IN HUMAN GLIOMA STEM CELLS: THE CENTRAL ROLE OF V-ATPASE PROTON PUMP ACTIVITY." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/542956.

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Recent evidences highlighted that glioblastomas (GBM) secreted microvesicles (EVs), particularly exosomes (Exo) and large oncosomes (LO), play a major role in the cross-talk between tumor cell and non-neoplastic parenchyma. Recent work from our group has identified the vacuolar pump H+-ATPase (V-ATPase) as an important effector of GBM growth and glioma stem cells (GSC) maintenance. Additionally, in ExoCarta database V-ATPase subunits have been described in Exo from different cancer cell types. Taken together, these data identify V-ATPase as an important driver of gliomagenesis, and a novel, ac

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32

Nishie, Mariko. "Downregulated ATP6V1B1 expression acidifies the intracellular environment of cancer cells leading to resistance to antibody-dependent cellular cytotoxicity." Kyoto University, 2021. http://hdl.handle.net/2433/261614.

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33

Vedovelli, Luca. "Alveolar surfactant phosphatidylglycerol, disaturated phosphatidylcholine, and SP-B kinetics in infants and adults with stable isotopes tracers, and H+V-ATPase activity in B1 subunit knockout mice." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3421974.

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Alveolar surfactant is the key physiological structure that every mammal utilizes to live while breathing air. It is a mixture of proteins and lipids that lines the external part of the alveoli and allows a water-based organism to use air as source of oxygen. Disorders in surfactant’s metabolism are known to be involved in life-threatening diseases like the acute respiratory distress syndrome and cystic fibrosis. In this thesis we describe the kinetics of two main surfactant’s phospholipids (phosphatidylglycerol and disaturated-phosphatidylcholine) and of its specific protein B, in vivo in hum

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34

Ibrahim, Abdulrazak Baba. "Resistência a mosca branca (Bemisia tabaci) em plantas transgênicas expressando siRNA do gene de uma v-ATPase." reponame:Repositório Institucional da UnB, 2015. http://repositorio.unb.br/handle/10482/19851.

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Tese (doutorado)—Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Biologia Celular, 2015.<br>Submitted by Tania Milca Carvalho Malheiros (tania@bce.unb.br) on 2016-04-04T18:11:36Z No. of bitstreams: 1 2015_AbdulrazakBabaIbrahim_Parcial.pdf: 138489 bytes, checksum: 26cc0275768c96350d0f878cb4affd71 (MD5)<br>Approved for entry into archive by Patrícia Nunes da Silva(patricia@bce.unb.br) on 2016-04-05T12:09:00Z (GMT) No. of bitstreams: 1 2015_AbdulrazakBabaIbrahim_Parcial.pdf: 138489 bytes, checksum: 26cc0275768c96350d0f878cb4affd71 (MD5)<br>Made available in DSpace

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Meehan, James. "Inhibition of pH regulation as a therapeutic strategy in breast cancer." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28875.

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The abnormal regulation of H+ ions, leading to a reversed pH gradient in cancer cells when compared to normal cells, is considered to be one of the most distinctive features of cancer. However, this characteristic has yet to be fully exploited as a therapeutic target in cancer. This project assessed whether targeting pH regulating proteins, which permit cancer cells to survive in the hostile hypoxic and acidic tumour microenvironment, could produce an effective therapeutic response in breast cancer. The pH regulating proteins carbonic anhydrase IX (CAIX), Na+/H+ exchanger 1 (NHE1) and vacuolar

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Rein, Julia, Martin Voss, Wolfgang Blenau, Bernd Walz, and Otto Baumann. "Hormone-induced assembly and activation of V-ATPase in blowfly salivary glands is mediated by protein kinase A." Universität Potsdam, 2008. http://opus.kobv.de/ubp/texte_eingeschraenkt_verlag/2010/4612/.

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The vacuolar H+-ATPase (V-ATPase) in the apical membrane of blowfly (Calliphora vicina) salivary gland cells energizes the secretion of a KCl-rich saliva in response to the neurohormone serotonin (5-HT). We have shown previously that exposure to 5-HT induces a cAMP-mediated reversible assembly of V-0 and V-1 subcomplexes to V-ATPase holoenzymes and increases V-ATPase-driven proton transport. Here, we analyze whether the effect of cAMP on V-ATPase is mediated by protein kinase A (PKA) or exchange protein directly activated by cAMP (Epac), the cAMP target proteins that are present within the sal

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Pizetta, Carolina Senhorinho Ramalho. "Silenciamento do gene de uma v-ATPase da mosca branca (Bemisia tabaci) por RNAi em tomateiro (Solanum lycopersicum)." reponame:Repositório Institucional da UnB, 2018. http://repositorio.unb.br/handle/10482/32453.

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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Agronomia e Medicina Veterinária, Programa de Pós-Graduação em Agronomia, 2018.<br>Submitted by Fabiana Santos (fabianacamargo@bce.unb.br) on 2018-08-17T21:16:25Z No. of bitstreams: 1 2018_CarolinaSenhorinhoRamalho.pdf: 1487059 bytes, checksum: 301d2c8ba2b5d034e440b516646d5bd7 (MD5)<br>Approved for entry into archive by Raquel Viana (raquelviana@bce.unb.br) on 2018-08-21T17:17:40Z (GMT) No. of bitstreams: 1 2018_CarolinaSenhorinhoRamalho.pdf: 1487059 bytes, checksum: 301d2c8ba2b5d034e440b516646d5bd7 (MD5)<br>Made available in DSpace

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Di, Giovanni Jérôme. "Implication de la calmoduline et de la V-ATPase dans la fusion membranaire et la libération de neurotransmetteurs." Aix-Marseille 2, 2009. http://www.theses.fr/2009AIX20678.

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L’exocytose des neurotransmetteurs repose sur la fusion des vésicules synaptiques avec la membrane plasmique en réponse à l’influx calcique qui accompagne les potentiels d’action. La fusion nécessite l’assemblage des protéines SNAREs de la vésicule (la VAMP2) et de la membrane plasmique (la syntaxine 1 et la SNAP25) à l’interface des deux bicouches lipidiques, et elle est déclenchée par la synaptotagmine, un senseur de Ca2+ aux propriétés fusogènes. Des senseurs calciques additionnels semblent participer au déclenchement de la libération et à la dynamique du pore de fusion, en particulier la c

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39

Liegeois, Samuel. "Sécrétion polarisée dans les tissus épitheliaux du nématode Caenorhabditis elegans : Rôle de la V-ATPase dans ce processus." Université Louis Pasteur (Strasbourg) (1971-2008), 2006. http://www.theses.fr/2006STR13075.

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40

Cannata, Serio Magda. "Mutations in V-ATPase assembly factors cause Congenital Disorder of Glycosylation (CDG) with autophagic liver disease Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects Mutations in the V-ATPase assembly factor VMA21 cause a congenital disorder of glycosylation with autophagic liver disease." Thesis, Sorbonne Paris Cité, 2019. https://wo.app.u-paris.fr/cgi-bin/WebObjects/TheseWeb.woa/wa/show?t=2277&f=17696.

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La pompe protonique V-ATPase est un complexe impliqué dans l'acidification intracellulaire. Elle est formée par le secteur V0 pour le transport des protons et le secteur V1 pour l'hydrolyse de l'ATP. Des études pionnières chez S. cerevisiae montrent que l'assemblage du secteur V0 commence dans le réticulum endoplasmique (ER) grâce au contrôle de 5 facteurs d'assemblage: Vma21p, Vma12p, Vma22p, Pkr1p et Voa1p. Une fois assemblé, le secteur V0 est transporté par Vma21p jusqu'au cis-Golgi, où, avec le secteur V1, constitue un holoenzyme fonctionnel. Ce processus chez l'homme n¿est pas encore clai

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Faysal, Joanne M. "The Effects of Hypoxia with Concomitant Acidosis on Prostate Cancer Cell Survival." Scholarly Repository, 2010. http://scholarlyrepository.miami.edu/oa_theses/69.

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Prostate cancer is the second most common cancer among men in the United States. While treatments for prostate cancer exist, none are curative. As a solid tumor, prostate cancer can grow beyond the diffusion limits of oxygen, thereby resulting in a hypoxic environment. While hypoxia can cause death to a variety of cell types, tumor cells can develop resistance to hypoxia and survive under minimal oxygen conditions. Hypoxia in tumor cells has also been associated with poor prognosis, increased metastasis, and decreased efficacy of chemotherapy. BNIP3, a BH-3 only proapoptotic Bcl-2 family

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Schempp, Christina Maria [Verfasser], and Angelika [Akademischer Betreuer] Vollmar. "The V-ATPase inhibitor archazolid : Impact on anoikis resistance in metastatic cancer cells / Christina Maria Schempp. Betreuer: Angelika Vollmar." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1050348745/34.

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Tognon, E. "REGULATION OF NOTCH SIGNALING BY THE ENDO-LYSOSOMAL SYSTEM IN DROSOPHILA: THE ROLE OF ESCRT-0 AND V-ATPASE." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/365704.

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ABSTRACT During my Ph.D., I have been involved in two different projects: 1. The study of the role of ESCRT-0 in Notch signaling and tumor suppression. 2. The study of the regulation of V-ATPase in a subset of Notch-dependent developmental processes. 1. Abstract Project 1 Sorting and degradation of ubiquitylated cargoes depends on the endosomal sorting required for transport (ESCRT) machinery. The ESCRT machinery is composed of four multi-subunit ESCRT complexes (ESCRT-0, -I, -II, -III), which act in a sequential fashion to deliver endocytic cargoes into the internal luminal vesicles (

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Kobia, F. M. "TARGETING NOTCH TRAFFICKING IN HUMAN CANCER CELLS: A. PHARMACOLOGIC INHIBITION OF THE VACUOLAR H+ ATPASE REDUCES PHYSIOLOGIC AND ONCOGENIC NOTCH SIGNALING. B. HIGH CONTENT SCREEN FOR NOVEL MODULATORS OF THE NOTCH PATHWAY." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/365255.

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Abstract: Notch signaling is prominently involved in cell fate decision and growth regulation in metazoan tissues. Because of this, Notch is often upregulated in cancer and current efforts point to developing drugs that block its activation. Notch receptor endocytosis towards acidic compartments is a recently appreciated determinant of signaling activation. The Vacuolar H+ ATPase (V-ATPase) is responsible for acidification of endocytic organelles and recently it has been shown that mutants in V-ATPase subunit encoding genes in model organisms display loss of Notch signaling phenotypes. In the

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Marais, Saberi. "XvVHA-c``1- a novel stress responsive V-ATPase subunit c`` homologue isolated from the resurrection plant Xerophyta viscosa Baker." Master's thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/4291.

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Gleize, Vincent. "Etude des sous-unités a de la v-ATPase : caractérisation de leurs interactions avec les protéines SNAREs et étude de l’expression par des gliomes de la sous-unité rénale a4." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA11T052.

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La v-ATPase est une pompe à protons. Elle permet l’acidification d’organelles, ce qui est indispensable à de nombreux processus cellulaires. Cette enzyme est composée de 14 sous-unités différentes, organisées en deux domaines, le domaine catalytique V1 et le domaine membranaire V0. La sous-unité a du domaine V0 est essentielle au transport des protons. Il en existe 4 isoformes (a1 à a4) et des variants d’épissage (a1-I à a1-IV pour a1) permettant à la v-ATPase d’être adressée vers différents compartiments et donc d’être impliquée dans différents processus. Deux projets visant à étudier cette s

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Schneider, Lina Sophie [Verfasser], and Angelika [Akademischer Betreuer] Vollmar. "Targeting the endolysosomal system of cancer cells by inhibition of V-ATPase and TPC function / Lina Sophie Schneider ; Betreuer: Angelika Vollmar." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1123957576/34.

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Gustavsson, Marie. "Studies of Intracellular Transport and Anticancer Drug Action by Functional Genomics in Yeast." Doctoral thesis, Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9408.

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This thesis describes the use of functional genomics screens in yeast to study anticancer drug action and intracellular transport. The yeast Saccharomyces cerevisiae provides a particularly useful model system for global drug screens, due to the availability of knockout mutants for all yeast genes. A complete collection of yeast deletion mutants was screened for sensitivity to monensin, a drug that affects intracellular transport. A total of 63 deletion mutants were recovered, and most of them were in genes involved in transport beyond the Golgi. Surprisingly, none of the V-ATPase subunits wer

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Sobreira, Alana CecÃlia de Menezes. "Estudo da expressÃo dos genes das bombas de prÃtons (V-ATPase e V-PPase) e dos contra-transportadores vacuolares (NHX) de Vigna unguiculata (L.) Walp submetidos a estresses abiÃticos." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=5344.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>O acÃmulo de Na+ no vacÃolo central representa um importante mecanismo de defesa de plantas contra o estresse salino. A regulaÃÃo dos volumes e conteÃdos dos vacÃolos de cÃlulas vegetais depende da atividade de transportadores e canais localizados no tonoplasto (membrana vacuolar). A membrana vacuolar possui duas distintas bombas de prÃtons (V-ATPase e V-PPase), aquoporinas e vÃrios sistemas de transportes ativos e/ou secundÃrios, como os contra-transportadores Na+/H+ vacuolares. As duas bombas de prÃtons transmembranares funcionam

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Sobreira, Alana Cecília de Menezes. "Estudo da expressão dos genes das bombas de prótons (V-ATPase e V-PPase) e dos contra-transportadores vacuolares (NHX) de Vigna unguiculata (L.) Walp submetidos a estresses abióticos." reponame:Repositório Institucional da UFC, 2012. http://www.repositorio.ufc.br/handle/riufc/4057.

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SOBREIRA, Alana Cecília de Menezes. Estudo da expressão dos genes das bombas de prótons (V-ATPase e V-PPase) e dos contra-transportadores vacuolares (NHX) de Vigna unguiculata (L.) Walp submetidos a estresses abióticos.2009 f. Dissertação (Mestrado em Bioquímica) - Centro de Ciências, Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, 2009.<br>Submitted by JOANA BEZERRA (joanabib@yahoo.com.br) on 2012-11-09T21:07:31Z No. of bitstreams: 1 2009_tese_acmsobreira.pdf: 1938746 bytes, checksum: 064fea08dd8578e2f6b67de140140d86 (MD5)<br>Approved for entry into

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