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1
Santos, Hercos Benigno Vicente. "Ecografía en Uveitis." Doctoral thesis, Universitat Autònoma de Barcelona, 2001. http://hdl.handle.net/10803/4242.
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Hofmaier, Florian. "Equine rezidivierende Uveitis." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-118798.
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Puchta, Joachim. "Experimentelle Melanin-induzierte Uveitis." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963814621.
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Garip-Kuebler, Aylin. "Rare anterior uveitis entities." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-167080.
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Puchta, Joachim. "Experimentelle Melanin-induzierte Uveitis." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2002. http://dx.doi.org/10.18452/14690.
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Experimentelle Melanin-induzierte Uveitis (EMIU): Modulation der Leukozyten-Endothelzell-Interaktion durch Makrophagendepletion - intravitalmikroskopische Analysen. Einleitung: Die Experimentelle Melanininduzierte Uveitis (EMIU) dient als Modell für eine autoimmune Iridozyklitis und Choroiditis. Die frühe Entzündungsreaktion ist durch eine gesteigerte Leukozyten-Endothel-Interaktion gekennzeichnet. Um die Rolle von Makrophagen bei der Induktion der EMIU zu untersuchen, analysierten wir Veränderungen der Leukozyten-Endothel-Interaktionen in Irisvenolen anästhesierter Ratten nach Makrophagendepletion mit liposomalem Clodronat. Methoden: Die EMIU wurde durch intraperitoneale Injektion einer Emulsion aus 250 µg bovinen Melanosomen in komplettem Freund Adjuvant und Pertussistoxin bei Lewis Ratten induziert. Die Tiere wurden mit 2 ml Clodronat-Liposomen (Clodronat-lip) an den Tagen 2; 1; 4; 6 beziehungsweise 8 nach Immunisierung behandelt. Kontrolltiere erhielten anstelle von Clodronat-lip Leerliposomen (Kontrolle). Für die Intravitalfluoreszenzmikroskopie wurden Leukozyten intravasal mit Rhodamin 6G gefärbt. Anschließend wurden die postkapillären Irisvenolen am 4.; 6.; 8. und 10. Tag untersucht, um die Zahl der rollenden und fest am Endothel adhärenten Leukozyten zu quantifizieren. Weitere Parameter wie Zellzahl und Proteingehalt des Kammerwassers, TNF-alpha und IFN-gamma im Plasma und das Differentialblutbild wurden zur Charakterisierung der Entzündungsreaktion herangezogen. Ergebnisse: Bei makrophagendepletierten Tieren konnten spaltlampenmikroskopisch keine entzündlichen Veränderungen des Vorderabschnittes beobachtet werden. Der prozentuale Anteil rollender Leukozyten war am 8. Tag mit 2 +/- 1.1 vs. 15.2 +/- 1.6; 5.2 +/- 0.5% (Clodronat-lip vs. EMIU; Kontrolle, Mittelwert +/- MSF, ANOVA, p
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Dua, Harminder Singh. "Immunomodulation of experimental autoimmune uveitis." Thesis, University of Aberdeen, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317710.
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Chronic posterior uveitis is a relatively common clinical disorder and an importance cause of visual impairment in young adults. Experimental autoimmune uveitis (EAU) and its associated experimental autoimmune pinealitis (EAP) induced by retinal autoantigens are predominantly CD4+ T cell mediated (auto) immune disease of the retina and uveal tract of the eye and the pineal gland respectively. EAU bears a close clinical and pathological resemblance to chronic posterior uveitis in humans and seves as a good animal model for the study of posterior uveitis. The EAU model was used to study means of modulating the host's immune response to suppress or inhibit the onset of uveitis. The onset of retinal S-antigen induced EAU could be successfully inhibited by pre-treating Lewis rats with a retinal S-antigen (carboxy terminus) specific monoclonal antibody called S2.4.C5. This however did not suppress the associated EAP indicating that the monoclonal antibody acted via the efferent arc of the immune mediated response. This prompted a study of the 'Blood-retinal and Blood-pineal barrier sites' during the active stages of EAU and EAP. Transmission electron microscopy of the vascular endothelium revealed changes resembling 'High endothelial venules' of lymph nodes in the retinal and pineal vasculature. In an attempt to identify one or more immunodominant epitopes of S-antigen that may be relevant to tolerance induction, an in-vitro and in-vivo study using enzyme digested preparations of S-antigen was carried out. This revealed that digestion of S-antigen by a protease derived from staphylococcus aureus V8 strain, not only inhibited the binding of the monoclonal S2.4.C5 in-vitro but was also associated with an in-vivo attenuation of the pathogenic response to S-antigen indicating that a dominant immunogenic epitope of S-antigen was located at the C-terminus of the molecule.
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Kotaniemi, Kaisu. "Uveitis in juvenile idiopathic arthritis." Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/laa/kliin/vk/kotaniemi/.
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Kottoor, Sherine Hermangild. "Regulatory T cells in human uveitis." Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/3000/.
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Regulatory T cells (Treg) are critical for the maintenance of tolerance to self and control of inflammation. Defects in Treg have been reported for a number of autoimmune and inflammatory diseases. In this thesis I wished to determine whether there are quantitative and/ or qualitative defects of Treg in patients with idiopathic non-infectious uveitis. Using stringent gating procedures, an increased frequency of CD4+CD25highCD127low Treg was observed in the peripheral blood of acute anterior uveitis (AAU) patients but not those with chronic disease. Treg from both acute and chronic anterior uveitis patients expressed defective suppressive capacity in vitro. I also observed an accumulation of memory Treg in the aqueous humor from AAU patients, expressing high levels of FoxP3 and CTLA-4. In vitro activated Treg upregulated their FoxP3 expression to levels as seen in the eye, suggesting that the aqueous humor Treg might be recently activated. Using an in vitro model for analysing Treg function, I observed that exposure to uveitis aqueous humor did not affect the suppressive ability of Treg. In summary, Treg with a potent regulatory phenotype accumulate in the aqueous humor of acute anterior uveitis patients, whereas the peripheral Treg population from both chronic and acute patients express a defective function.
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Chang, John Hyun-Min Medical Sciences Faculty of Medicine UNSW. "Pattern recognition receptors in the immunopathogenesis of acute anterior uveitis." Awarded by:University of New South Wales. School of Medical Sciences, 2006. http://handle.unsw.edu.au/1959.4/25756.
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Acute anterior uveitis (AAU) is the most common form of intraocular inflammatory disease and an important cause of visual impairment. Microbial triggers to the development of AAU have been strongly implicated, however the pathogenesis and molecular mechanisms for this are unclear. Toll-like receptors (TLR) and nucleotide oligomerisation domain receptors (NOD) are pattern recognition receptors (PRR) of the innate immune system that facilitate immediate recognition and immunostimulatory responses to unique molecular patterns of microbial components, including the production of chemoattractant cytokines called chemokines. The major aim of this study was to investigate the role of PRRs, namely TLRs and NODs, in the pathogenesis of human AAU. The mRNA and protein expressions of TLR4 and NOD2 in the normal human eye were determined by RT-PCR and immunohistochemistry. Resident antigen presenting cells of the normal human uvea expressed TLR4 protein. NOD2 protein expression was highly restricted to a subpopulation of retinal cells. A selective perturbation in the expression and function of TLRs were demonstrated in active human AAU by flow cytometry and in vitro stimulation with selective TLR agonists. These changes were not due to any polymorphisms in the TLR genes. Elevated plasma levels of lipopolysaccharide (LPS), an agonist for TLR4, were not detected in patients with active AAU by the limulus amebocyte lysate assay. New information regarding the complex in vivo network of cytokines in active human AAU were provided by multiplex cytokine bead immunoassay on aqueous humor samples, including a Th1-polarised pattern of aqueous humor cytokines, the intraocular expression of multiple LPS-inducible cytokines, and the aqueous humor expression of cytokines such as IL-17 in AAU. Expressions of the respective chemokine receptors on peripheral blood leukocytes were also determined. The findings of this study provides several lines of evidence to support the hypothesis that PRRs, namely TLRs and NODs, are of pathogenic importance in the development of clinical AAU. The results of this study provide significant new information regarding the role of PRRs in ocular immunity and immune privilege, their role in the pathogenesis of AAU, and it provides a molecular mechanism whereby microbial triggers could initiate the development of uveitis.
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Girol, Ana Paula [UNESP]. "Efeito anti-inflamatórios e mecanismo de ação da proteína anexina A1 em modelo de uveíte induzida por endotoxina." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/102748.
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girol_ap_dr_sjrp.pdf: 2767675 bytes, checksum: affebf6e5d0ac59da5e241e14d9b3745 (MD5)A proteína anexina A1 (AnxA1) apresenta importantes propriedades anti-inflamatórias e estudos sugerem que suas ações podem ser mediadas por receptores para peptídeos formilados (FPR). Embora os efeitos anti-inflamatórios da AnxA1 e de seus peptídeos miméticos, especialmente o Ac2-26, tenham sido explorados em diversas investigações, são raros os estudos da AnxA1 nas inflamações oculares. Em razão dos graves efeitos colaterais dos tratamentos atuais para a uveíte, uma importante causa de cegueira, investigamos, in vivo, os efeitos e o mecanismo de ação da AnxA1 nos tecidos oculares de roedores na uveíte induzida por endotoxina (EIU). Ratos machos (Rattus novergicus) foram anestesiados e inoculados, por via subcutânea, na pata direita com lipopolissacarídeo (LPS) (100µg) para o desenvolvimento da uveíte. Após, foram divididos em grupos experimentais (n=10/grupo): EIU por 24 e 48h; EIU por 24h e tratados farmacologicamente por administrações tópica e sistêmica do peptídeo Ac2-26 (100µg) e EIU 24h tratado sistemicamente com peptídeo e Boc2, antagonista do FPR (50µg/animal). Para confirmar a importância da AnxA1 endógena na resolução da inflamação ocular, camundongos selvagens e deficientes para AnxA1 (AnxA1-/-) foram induzidos à uveíte por 24h sem tratamento. Nesses animais AnxA1-/- a resposta inflamatória foi exacerbada em comparação com os selvagens. Enquanto, nos olhos dos ratos, as análises quantitativas dos leucócitos, dosagens de interleucina (IL)-1β, IL-6, fator de necrose tumoral (TNF)-α, óxido nítrico (NO) e expressão da ciclo-oxigenase (COX)-2 nos tecidos e/ou no humor aquoso indicaram os efeitos anti-inflamatórios do peptídeo. Efeitos que foram revertidos na presença do Boc2. As análises imuno-histoquímicas das proteínas AnxA1, AnxA1 fosforilada em...
Annexin A1 (AnxA1) is a protein that displays anti-inflammatory properties and some studies suggest that its effects may be mediated by formyl peptide receptors (FPR). Although the anti-inflammatory activities of AnxA1 and its mimetic peptides, including Ac2-26, have been explored in several investigations, the role of AnxA1 in ocular inflammatory processes has not yet been elucidated. Given the common side effects of the current therapies used to treat uveitis, an important cause of blindness worldwide, we investigated, in vivo, the AnxA1 effects and mechanism of action in endotoxin-induced uveitis (EIU). Rattus norvegicus were induced to uveitis (lipopolysaccharide - 100 µg) and divided into experimental groups (n=10/group): EIU untreated for 24 and 48h, EIU treated with topical applications (4/4h) or a single intravenous injection of Ac2-26 (100µg) and EIU systemically treated with the peptide and Boc2, the FPR antagonist (50µg/animal). To confirm the importance of endogenous AnxA1 in the resolution of ocular inflammation, wild-type and AnxA1 deficient (AnxA1-/-) mice were also induced to uveitis without treatment for 24h. AnxA1-/- mice showed exacerbated inflammation compared to wild-type animals. As, quantitative analyses of leukocytes, interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, nitric oxide (NO) levels and cyclooxigenase (COX)-2 expression in ocular tissues and/or in aqueous humor of rats eyes revealed the anti-inflammatory effects of the peptide, which were abrogated in the Boc2 presence. Immunohistochemical analysis of AnxA1, serine-or-tyrosine-phosphorylated AnxA1 (AnxA-S27-PO4 - AnxA-Y21-PO4) in the ocular tissues showed AnxA1 and AnxA1-S27-PO4 expression in epithelial (cornea, iris and ciliary processes) and nervous cells. These expressions were increased in... (Complete abstract click electronic access below)
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Tömördy, Elke. "Verlaufsstudie nach Vitrektomie bei equiner rezidivierender Uveitis /." [S.l.] : [s.n.], 2009. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000292629.
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Eckenweiler, Judith. "Die Elektroretinographie bei equinen Uveitis- und Glaukompatienten." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-88060.
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Atan, Deniz. "Cytokine gene polymorphism in non-infectious uveitis." Thesis, University of Bristol, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.492470.
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Non-infectious uveitis is a blinding intraocular inflammatory disorder with an autoimmune pathogenesis. Like other autoimmune diseases, uveitis has multifactorial and polygenic aetiology. The results of this study have shown that polymorphisms of the ILIO and TNF genes influence the susceptibility and seventy of uveitis. These polymorphisms were either known to correlate with altered transcription levels, or linked with other polymorphisms positioned within regulatory conserved non-coding sequences. Thus the identification of specific genetic variants that confer susceptibility or resistance to uveitis has provided insights into the pathogenesis of uveitis, and might allow the prediction of patients who will have aggressive disease to allow tailoring of treatment to the individual.
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Joshi, L. "Evaluating novel & established therapies for uveitis." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1324538/.
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Ocular inflammatory diseases, which include uveitis, are a leading cause of visual impairment. A number of systemic immunosuppressive agents (ISAs) are available, as well as biological therapies. However, these therapies may not always be effective and can be limited by toxicity. This thesis aimed to evaluate established and emerging therapies in ocular inflammatory disease. The reasons for changing ISAs and the success of subsequent ISA regimes have not previously been investigated for ocular inflammatory diseases. A review of a case series of 64 uveitis patients on ISAs revealed that the commonest reason for a treatment failing was lack of efficacy. A comparison between the most commonly used strategies after treatment failure, such as switching strategies (eg switch-to mycophenolate vs switch-to methotrexate) and add-on strategies (eg add-on azathioprine vs mycophenolate) revealed no significant difference in the time-to-success and retention times. The long-term efficacy and effects of repeat therapy with rituximab (anti-B cell therapy) in ocular Wegener’s granulomatosis (WG) was evaluated in the largest case series reported to date. Rituximab was effective in inducing remission, but relapse occurred in 33% of patients at about 12 months, and could be predicted by rising anti-PR3 titres. Retreatment with rituximab was effective. The work presented in the final part of this thesis utilised murine models of experimental autoimmune uveitis (EAU) to evaluate novel tumour necrosis factor (TNF) inhibitory therapies. EAU was initially characterised in two strains of mice, C57B/6 and B10.RIII, to identify key therapeutic windows and key target inflammatory cytokines. When testing the TNF inhibitor therapies, the EAU model failed due to possible genetic contamination of the B10.RIII strain from the supplier, this is still an on-going issue. However, some of the TNF inhibitory therapies administered by intravitreal injection increased the degree of inflammation compared to those injected with a placebo control.
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Blosser, Peter, Remil Simon, and Courtney Ridner. "Differential Diagnosis of Pan-Uveitis: Behçet’s Disease." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/asrf/2018/schedule/2.
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This report describes the case of a 56-year-old man who presented with blurry vision, increased intraocular pressure, and conjunctival injection after posterior chamber intraocular lens implantation. Initially post-operative endophalmitis and foreign body inflammation were considered as differential diagnoses, but after further examination pan-uveitis was diagnosed. Uveitis is an ocular finding that may indicate several diseases, one of which is Behçet’s Disease. During the interview, the patient mentioned a history of apthous ulcers and genital ulcers which then lead to the clinical diagnosis of Behçet’s Disease. This report emphasizes that Behçet’s Disease is rare in Caucasians. Therefore, is frequently misdiagnosed in North America due to variable presentations and by not exploring the option when analyzing differential diagnoses. Early diagnosis and intervention will prevent the development of blindness and fatality due to complications of the disease.
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Kalsi, Gursharan Singh. "Cyclosporine--ocular absorption, pharmacokinetics & effects on uveitis." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/26422.
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Inflammatory ocular disease is an important cause of
blindness and uveitis accounts for 1.0% of blind patients
in Canada.¹ This disease can be particularly troublesome to
treat, because the nature of the causal factor or factors
and mechanisms of progressi n are usually unknown.
Non-specific anti - inflammatory agents have been used
orally and systemically with some success to treat
uveitis, ²⁻⁸ but they may produce serious side effects both
locally and elsewhere in the body.⁹̛¹²̛¹⁴ With prolonged
use tolerance to these drugs may develop , making them
ineffective. Recently a powerful immuno suppressive agent,
Cyclosporine (Cy), used orally and systemically in the
treatment of uveitis has shown promising results.¹⁶⁻¹⁹̛²⁸
However, its routine use is limited because of a narrow
therapeutic index and renal toxicity. Several studies have shown that subconjunctival injection of a number of antineoplastic agents enhanced
ocular absorption ²⁰⁻²⁴ in a traditional pharmacological
sanctuary,¹³̛¹⁴ and circumvented the associated systemic
side effects. Therefore, if Cy were administered
subconjunctivally it might be possible to avoid the side
effects associated with the oral and systemic routes, and
at the same time provide higher levels of Cy to the eye.
A protocol for the administration of Cy subconjunctivally was developed in New Zealand white rabbits, to study toxicity, ocular pharmacokinetics following equidose administration subconjunctivally and systemically and the effects of Cy on an animal model of uveitis. Subconjuntival administration of 5mg of Cy in O.lcc (Sandimmune I.V.(R) 50 mg/ml) weekly was found to be the maximum tolerated dose by the rabbitsˈ eye, and was superior to intravenous injection for ocular penetration while minimizing systemic exposure. The uveitis model showed that Cy was effective in reducing the inflammatory response and the earlier the application of Cy the milder the uveitis.
The results from our study support the contention that local administration of Cy would lead to higher levels of Cy absorption and circumvent the side effects of systemic administration. This may facilitate the routine use of Cy in ocular inflammatory disease.Medicine, Faculty of
Pathology and Laboratory Medicine, Department of
Graduate
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Brich, Michelle [UNESP]. "Infecção Experimental com Leptospira interrogans sorovariedade Canicola, relacionada à pesquisa de alterações oculares em cães." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/94639.
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brich_m_me_jabo.pdf: 460245 bytes, checksum: 3dd3a22b2996a7679b355cb0da04c9d3 (MD5)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
A uveíte em mamíferos tem sido relacionada à infecção por Leptospira spp., e, embora ocorra com maior frequência na espécie equina, já foi observada e relatada em outras espécies mamíferas, inclusive na humana. O objetivo deste trabalho foi investigar a relação entre a infecção por leptospiras e a ocorrência de alterações oculares em cães. Para a obtenção dos dados foram utilizados 32 cães, em idade reprodutiva, recolhidos pelo Centro de Controle de Zoonoses do Município de São José do Rio Preto, que apresentaram reação negativa, em duas provas de soroaglutinação microscópica (SAM) no intervalo de sete dias. Dos 32 cães, 20 foram inoculados com uma cepa patogênica de Leptospira interrogans sorovariedade Canicola e 12 formaram o grupo controle. Com a finalidade de avaliar as possíveis alterações do globo ocular post mortem, oito cães (cinco inoculados e três controles) foram sacrificados nos dias: sete, 15, 30 e 45 após o dia da inoculação. Amostras de humor aquoso, de um dos olhos de cada animal, foram retiradas para realização de PCR e SAM; o outro globo ocular foi retirado para realização de exame histopatológico e para a técnica de coloração de Levaditi. Nos dias zero, três, cinco, sete, 10 e após, a cada cinco dias, inclusive no dia do sacrifício, foram realizadas avaliações do estado físico do animal, do globo ocular e realizadas colheitas de sangue. O soro sanguíneo foi submetido à SAM para estabelecer os títulos obtidos em cada fase da infecção. Embora todos os animais tenham apresentado títulos sorológicos, indicando o sucesso da infecção, nenhum dos testes de detecção resultou positivo em até 45 dias de observação; no exame clínico apenas três animais apresentaram alterações perceptíveis: dois apresentavam irritação ocular, com hiperemia da esclera e um animal apresentava lacrimejamento...
Uveitis in mammals has been related to Leptospira spp. And although it occurs more frequently in the horse has already been observed and reported in other mammalian species, including the human. The aim of this study was to investigate the relationship between leptospira infection and the occurrence of ocular changes in dogs. To obtain the data were used 32 dogs in the reproductive age, collected by the Center for Zoonosis Control in São José do Rio Preto, which showed negative reaction in both tests of microscopic agglutination test (MAT) within seven days. Of the 32 dogs, 20 were inoculated with a pathogenic strain of Leptospira interrogans sorovar Canicola and 12 formed the control group. With the aim of assessing possible changes of the eye post mortem, eight dogs (five inoculated and three controls) were sacrificed on days: seven, 15, 30 and 45 days after inoculation. Samples of aqueous humor of one eye of each animal were removed for PCR, and MAT, and the other eye was removed for histological examination and the staining technique Levaditi. On days zero, three, five, seven, 10 and, thereafter, every five days, including the day of sacrifice, were assessed the physical condition of the animal, the eyeball and blood samples. The serum was subjected to SAM to establish the qualifications obtained at each stage of infection. Although all animals have serologic evidence indicating the success of infection, no detection tests resulted positive in up to 45 days of observation and by clinical examination only three animals showed noticeable changes: two had eye irritation with redness of the sclera and one animal showed tearing. We conclude that 45 days of infection with Leptospira interrogans sorovar Canicola are not enough to cause serious damage to the ocular system of dogs
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Souza, Ana Letícia Groszewicz de [UNESP]. "Histopatologia e imunoistoquímica do bulbo do olho de equinos (Equus caballus, Linnaeus, 1758) soropositivos ou soronegativos para leptospirose." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/101106.
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souza_alg_dr_jabo.pdf: 506979 bytes, checksum: 5a430e51363e4d4ee82edd075b0a69ce (MD5)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
A doença endógena inflamatória uveal em equinos constitui resposta imunopatogênica complexa, onde se admite a participação de uma variedade de antígenos. A uveíte recorrente dos equinos (URE), também denominada ophthalmia periódica ou moon blindness, é uma panuveíte e constitui-se na causa mais comum de diminuição da percepção visual, cuja patogênese permanece, ainda, sob investigação. Inúmeras pesquisas apontam para a hipótese de hipersensibilidade a antígenos bacterianos. A maioria dos estudos mostra evidências de infecção por Leptospira sp.. Examinaram-se, ao acaso, os olhos de 29 animais e coletaram-se o soro, o humor aquoso e o corpo vítreo para proteinograma e aglutinação microscópica para Leptospira sp.. Outrossim, fragmentos de córnea, íris, retina e coróide para histopatologia e imunoistoquímica. A prova de aglutinação microscópica identificou 14 animais positivos, seis animais com titulação igual a 40 e nove indivíduos negativos para as amostras de soro. Houve um animal positivo na amostra de humor aquoso e na de corpo vítreo e outro negativo na de soro (titulação 40), mas positivo na de corpo vítreo. Foram encontrados os sorovares icterohaemorrhagiae, autumalis, patoc, sentot, habdomadis. Foram identificadas, à eletroforese do soro, as proteínas: imunoglobulina A; ceruloplasmina; trasnferrina; hemopexina; albumina; anti-tripsina; imunoglobulina G de cadeia pesada; haptoglobina; glicoproteína ácida; imunoglobulina G de cadeia leve e proteína de 25kda. A única proteína que mostrou resultado estatístico significativo foi a ceruplasmina (p=0,05) com animais soropositivos para leptospirose. À histopatologia a espessura da córnea foi significativamente maior nos animais soropositivos (p=0,0347). O exame imunistoquímico para pesquisa da bactéria Leptospira sp. mostrou maior...
Endogenous uveal inflammatory disease in the horse represent a complex immunopathological response to a range of presumed antigens. Equine recurrent uveitis (ERU) is a panuveitis and the most commmon cause of blindness in horses. Many researchers favour the hypothesis that ERU is delayed type hypersensitivity response to bacterial antigens. New findings show evidence of leptospiral infection in ERU eyes. Fifity eight eyeballs from twenty nine horses randomly selected were studied using histopathology and immunohistochemistry. The serum from 29 animals, aqueous humor an vitreous body from 58 eyes were collected for proteinogram and microscopic agglutination test (MAT) for Leptospira sp.. The microscopic agluttination test was identified 14 positive animals, six with titer 40 and nine negative in serum samples. One seropositive animal was positive in aquaeous humor and vitreous body and another seronegative horse was positive in vitreous body. Were found five serovars from 26 studied from Leptospira interrogans: icterohaemorrhagiae, autumalis, patoc, sentot, habdomadis. Were identified by serum electrophoresis, the following proteins: immunoglobulin A; ceruloplasmin; trasnferrina; hemopexina; albumin, anti-trypsin, the heavy chain of immunoglobulin G; haptoglobin; glycoprotein, immunoglobulin G and the light chain protein, 25kda. The only protein that showed significant results with seropositive horses was ceruplasmin (p = 0.05). The pathomorphologic changes on HE-stained sections showed that seropositive animals for leptospirosis had corneal thickness significantly higher than the seronegative (p = 0.0347). The immunohistochemistry test for Leptospira sp. showed higher positivity in samples of cornea, and some animals were seronegative but positive for this test. At immunohistochemistry was observed that the anti-metalloproteinase... (Complete abstract click electronic access below)
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Read, Russell W. "The role of complement in experimental autoimmune uveitis." Thesis, Birmingham, Ala. : University of Alabama at Birmingham, 2007. https://www.mhsl.uab.edu/dt/2007p/read.pdf.
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Morgan, James. "Analysis of candidate retinal autoantigens in autoimmune uveitis." Thesis, University of Nottingham, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415718.
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Kabasele, P. "Causes of visual loss in patients with uveitis." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1401758/.
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The last major study of causes of vision loss in 600 eyes with uveitis was published over 10 years ago and there have been many advances in treatment over this time. In this thesis I undertook a study of 1594 patients (2593 eyes) with uveitis currently attending the clinic, 75% of whom were aged between 24 and 63 years. The type of uveitis, sight threatening complications that developed and treatment were followed from presentation to final follow up. At presentation, 16% of eyes had BCVA ≤ 6/18 (e.g. 6/18-6/36) and 14% of affected eyes had BCVA 6/60 or worse. At one year follow-up, we found 11% of eyes with vision loss to 6/18-6/36 and 8% of eyes with severe visual loss or blindness. In the group of eyes followed up for 10 years or more, 19% developed severe visual loss or blindness and 16% developed vision loss to 6/18-6/36. Chronic macular damage was the main cause of visual loss, accounting for both for visual impairment and for severe visual loss, accounting for 41% and 36% respectively. Cystoid macular oedema accounted for 29% in visual impairment and 19% in severe visual loss or blindness. When classified by uveitis types, CMO was the main cause of vision loss in intermediate uveitis (38%), glaucoma was the leading cause in anterior uveitis (32%), and chronic macular damage accounted for 46% in posterior/panuveitis. Additionally, I looked at the outcome and subsequent impact on vision of ocular surgery for cataract, glaucoma and vitreo-retinal procedures. Visual prognosis after cataract surgery was favourable in anterior and intermediate uveitis. Eyes which underwent glaucoma surgery had vision stabilised or slightly improved over time. The mean log MAR BCVA prior to glaucoma surgery was 0.53+/- 60, and 0.31+/- 49 at final follow-up visit. (P= 0.012). There was no statistically significant improvement in visual acuity in eyes which had undergone vitreo-retinal procedures. The mean logMAR BCVA were 1.1+/-0.82 and 0.87+/-0.80 respectively pre-operative and at last post- op visit. (P=0.28) The 3rd main results chapter looks at patients presenting with retinal vasculitis who had ischemia and the long term outcome for these eyes. Of the 106 eyes which developed ischemia, 24% had vision loss to 6/18-6/36 at presentation, 23% of these had BCVA 6/60 or worse. Chronic macular damage was the main cause of visual impairment and accounted for 36%, macular ischemia accounted for 67% of severe visual loss or blindness. I found that in most eyes with ischemia, visual loss developed early in the first 5 years and do not worsen with time.
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Minas, Konstantinos. "New approaches to autoimmune therapy through gene analysis." Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted no access until May 19, 2011. Online version available for University member only until May 19, 2012, 2008. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=25620.
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Pearce, Jacqueline Winona. "Detection of Leptospira interrogans in fixed equine eyes affected with end-stage equine recurrent uveitis." Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/4925.
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Thesis (M.S.)--University of Missouri-Columbia, 2007."May 2007" The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Includes bibliographical references.
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De, Smet Joseph Marc Dominique. "Observations in clinical and experimental ocular autoimmunity." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/83518.
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Proefschrift Universiteit van Amsterdam.Omslagtitel: Observations on clinical and experimental ocular autoimmunity. - Auteursnaam op omslag: Marc D. de Smet. Met lit. opg. - Met samenvatting in het Nederlands.
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Popp, Michaela Karin. "Enrofloxacin im Glaskörper an Equiner rezidivierender Uveitis erkrankter Pferde." Diss., lmu, 2011. http://nbn-resolving.de/urn:nbn:de:bvb:19-135275.
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Zhao, Zi-Shan. "T cell effector mechanisms in experimental autoimmune uveitis (EAU)." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294788.
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Shirodkar, A. "Retinal vascular involvement in uveitis and new treatment options." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1348740/.
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The retinal blood vessels can become occluded due to both inflammation and thromboembolic diseases, and the main aim of this thesis is to examine the features of retinal vein occlusion (RVO) in patients with co-existing ocular inflammation to determine risk factors for the development of RVO, risk factors predictive of a poor visual outcome in uveitis, the prevalence of anti phospholipid antibody-based disease and the role of antiphospholipid antibody (aPL) testing. In this thesis, I also explore the efficacy of new treatments for retinal vein occlusion, particularly the Ozurdex intravitreal dexamethasone implant, which can also be used to treat uveitis and uveitis macular oedema. Demographic and clinical variables were extracted from the medical notes of three separate sample groups of patients attending Moorfields Eye hospital including: 1) patients attending a Uveitis clinic between 2009-2011 with a new or past history of RVO; 2) any patient who had aPL testing performed during 2010; 3) patients recruited onto the initial Ozurdex for uveitis phase III clinical trial. 34 RVO events were recorded during a two year period with an overall clinic prevalence of 1.83%. Presenting ocular features and risk factors for RVO in uveitis patients were explored. aPL testing was commonly performed on patients with RVO in an Ophthalmology setting, and the usefulness of this and its relation to RVO events were examined. Finally, follow up data for uveitis patients treated with a single Ozurdex implant were explored to determine the longer-term outcome of this treatment, and the strategies employed as and when patients relapsed, comparing these outcomes with those of the Ozurdex implant.
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Sachetto, Zoraida 1973. "Doença de Behçet = dados demográficos e manifestações clínicas em 87 pacientes acompanhados no ambulatório de vasculites do Hospital das Clínicas da Cidade de Campinas." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310636.
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Orientadores: Manoel Barros Bértolo, Lilian Tereza Lavras CostallatTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-18T20:20:25Z (GMT). No. of bitstreams: 1 Sachetto_Zoraida_D.pdf: 1287056 bytes, checksum: 4d011e5c6f0abde49d8ded578bf64042 (MD5) Previous issue date: 2011
Resumo: Objetivo: Descrever os dados demográficos e as manifestações clinicas de pacientes com diagnostico de Doença de Behcet acompanhados no ambulatório de vasculites do Hospital das Clinicas da cidade de Campinas, São Paulo, Brasil. Métodos: O estudo foi realizado através da revisão dos prontuários de todos os pacientes com diagnostico de Doença de Behcet atendidos e/ou acompanhados no ambulatório de vasculites da Disciplina de Reumatologia do Hospital das Clinicas da Universidade Estadual de Campinas, São Paulo, Brasil, no período de 1988 a 2010. Resultados: Foram incluídos no estudo oitenta e sete pacientes. A proporção entre os sexos foi de M/F = 0,84 e a media de idade do inicio da doença foi de 28,03 + ou - 7,57 anos. Lesão aftosa oral foi a manifestação clinica mais comum (100%). Ulceras genitais também foram comuns (77%), seguidas pela pseudofoliculite (47,67%). Envolvimento ocular esteve presente em 80% e envolvimento neurológico em 31,03% dos pacientes. Artralgia foi relatada em 31,03% e artrite em 13,79% dos casos. O envolvimento vascular foi encontrado em 13,95% dos pacientes. Somente 1,14% apresentaram envolvimento gastrointestinal. Conclusão: Nesta serie de casos, realizada em um pais da America do Sul, foram encontrados resultados semelhantes aos previamente descritos em diferentes áreas endêmicas da doença, com uma maior frequência das manifestações oculares e neurológicas
Abstract: Objective: To analyze demographic and clinical features in patients diagnosed with Behcet's disease (BD) in Brazil. Methods: We performed a retrospective review of all the patients' records with BD diagnosed from 1988 to 2010 in the Rheumatology Department at the State University of Campinas (UNICAMP). All patients had to fulfill the International Study Group for Behcet's disease diagnostic criteria. Results: Eighty-seven patients were included in the study. The male/female rate was 0,84 and the mean age at the onset of the disease was 28.03 + or - 7.57 years. Oral aphtosis was the most frequent manifestation (100%). Genital aphtosis was also frequent (77%), followed by pseudofolliculitis (47.67%). Ocular symptoms were present in 80% and neurologic manifestations in 31.03% of the patients. Arthralgia was reported in 31.03% and arthritis in 13.79% of the cases. Vascular involvement was seen in 13.95% of the patients. Only 1.14% had gastrointestinal involvement. Conclusion: This series, from a South American country, showed a similar general pattern of the BD to those found in different endemic areas in the world, with a high frequency of ocular and neurological manifestations
Doutorado
Clinica Medica
Doutor em Clínica Médica
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Walla, Therese [Verfasser]. "Morphological changes and outcome in CMV anterior uveitis / Therese Walla." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2019. http://d-nb.info/1202042953/34.
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Garip-Kübler, Aylin [Verfasser], and Gerhild [Akademischer Betreuer] Wildner. "Rare anterior uveitis entities / Aylin Garip-Kübler. Betreuer: Gerhild Wildner." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2014. http://d-nb.info/1049890922/34.
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Baumgart, Alessandra. "Cyclosporin A und dessen möglicher Einsatz bei der Tigerschecken-Uveitis." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-168992.
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Sharief, L. A. T. "Local and systemic factors impacting on visual outcome in uveitis." Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1527544/.
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Uveitis is the fourth most common cause of blindness among the working age group in developed countries. The aim of this research is to examine the influence of diabetes mellitus, cataract surgery, and retinal vasculitis on the visual outcome and prognosis of eyes with uveitis. The studied cohort included 1169 patients with uveitis attending Moorfields Eye Hospital between January 2012 and December 2013. The first study divided uveitis cases with diabetes into two groups; the first group included 99 eyes with diabetes diagnosed prior to uveitis. The second group included 96 eyes with uveitis later diagnosed with diabetes. Within the first group, 28.2% had vision loss mainly from maculopathy with the risk of vision loss 4.6 times higher when compared to the control group of non-diabetic uveitis group. The diagnosis of diabetes in the second group was associated with a drop in the mean vision over the year post diagnosis. The mean dose of corticosteroid was lower post diagnosis (15 mg versus 10 mg, p=0.03), and relapses were significantly less often treated with systemic corticosteroid alone (70.2% vs. 55.6% of the relapses, p=0.003). The second study included 236 eyes with retinal vasculitis (121 ischaemic, 115 non- ischaemic) which was compared to non-vasculitis control group (1022 eyes). Macular ischaemia increased the risk of vision loss in vasculitis by 4.4 times. Retinal vasculitis had twice the risk of macular oedema compared to non-vasculitis. Macular oedema and ischaemia increased risk of vision loss in ischaemic vasculitis while corticosteroids reduce the risk by 30%. Retinal ischaemia involving ≥ 2 quadrants was associated with increased risk of NV formation. The third study included 228 uveitic eyes undergone cataract surgery and was compared to a control group of 300 phakic eyes with uveitis. The vision continued to improve from the baseline first postoperative week. However, risk of vision loss and CMO were twice more in the pseudophakic group compared to the control. The rate of uveitis relapse and rate of using high dose of corticosteroids was significantly lower postoperatively versus preoperatively.
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Köhlein, Sophie. "Stellenwert der PCR zur Diagnostik von Keratitis und Uveitis anterior." kostenfrei, 2008. http://mediatum2.ub.tum.de/doc/633320/633320.pdf.
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Huang, Xiufeng. "Immunogenetics of acute anterior uveitis and comparison to ankylosing spondylitis." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/213839/1/Xiufeng_Huang_Thesis.pdf.
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This thesis comprehensively applies genome-wide association study, Mendelian randomization analyses, and cytokine proteomics to investigate the genetic basis and immunopathogenic mechanisms of acute anterior uveitis (AAU). Multiple susceptibility loci, environmental risk factors, and potential biomarkers are identified, and a polygenic risk score for AAU developed. These findings provide novel insights into the immunogenetics in AAU, and contribute to clinical translational studies.
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Paula, Raquel Joana Nicolas de. "Uveítes felinas : etiologia e abordagem clínica." Master's thesis, Universidade de Lisboa, Faculdade de Medicina Veterinária, 2016. http://hdl.handle.net/10400.5/11841.
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Dissertação de Mestrado Integrado em Medicina VeterináriaA uveíte é uma das afeções oculares mais frequentes nos gatos, e está muitas das vezes associada a patologias sistémicas. O principal objetivo deste estudo retrospetivo foi contribuir para a caracterização das uveítes felinas na população em estudo, classificando as uveítes e investigando as suas principais causas. A população em estudo incluiu 50 gatos com uveíte que se apresentaram à consulta de oftalmologia no Hospital Veterinário do Restelo entre 2010 e 2016. A população em estudo incluiu 54% machos e 46% fêmeas. Os pacientes tinham idades compreendidas entre os 2 meses e os 16 anos, com uma média de 6,1 ± 5,21 anos, e 40% eram jovens, 36% adultos e 24% séniores. Relativamente às raças afetadas, 62% dos doentes eram Europeu Comum, 16% Siamês, 14% Persa, 4% Bosques da Noruega, 2% Chartreux e 2% Scottish Fold. As uveítes identificadas eram na maioria unilaterais com uma representação de 64% da amostra, e quanto à localização, 66% eram uveítes anteriores, 16% uveítes posteriores e 18% panuveítes. O sinal clínico característico das uveítes anteriores que surgiu com maior frequência foi o efeito de Tyndall e os das uveítes posteriores foram as lesões inativas no fundo do olho. Em 68% dos casos foi possível diagnosticar a causa da uveíte. Contudo, em 32% da amostra a causa manteve-se desconhecida por condicionantes na realização dos exames complementares de diagnóstico. Em relação à etiologia das uveítes, 59% eram de origem sistémica e 41% de origem ocular. As causas sistémicas mais frequentes foram a infeção por T. gondii (14,5%) e por B. henselae (14,5%), e a causa ocular mais frequente foi o trauma (17%). A partir deste estudo foi possível concluir que existe uma grande dificuldade em obter um diagnóstico etiológico definitivo. A realização de um exame oftálmico completo, como parte integrante do exame físico de rotina, é necessária e deve haver uma maior sensibilidade de diagnóstico de inflamação uveal por parte dos clínicos gerais, para que esta não passe despercebida e seja corretamente tratada ou referenciada para um clínico especialista evitando assim a lesão grave e irreversível das estruturas oculares
ABSTRACT - FELINE UVEITIS: ETIOLOGY AND CLINICAL APPROACH - Uveitis is one of the most common forms of feline ocular disease, and is often associated with systemic diseases. The aim of this retrospective study is to contribute to feline uveitis characterization in the studied population, classifying uveitis and investigating their main causes. The studied population included 50 cats with uveitis that attended the ophthalmology referral consult at a veterinary hospital in Lisbon, between 2010 and 2016. The study population comprised 54% males and 46% females. The patients were aged between 2 months and 16 years, median 6,1 ± 5,21 years, and 40% were young, 36% adults and 24% seniors. Concerning affected breed, 62% of the patients were Domestic Shorthair, 16% Siamese, 14% Persian, 4% Norwegian Forest, 2% Chartreux and 2% Scottish Fold. Identified uveitis were mostly unilateral with a representation of 64% of the study population, and concerning localization, 66% were anterior uveitis, 16% posterior uveitis and 18% were panuveitis. The clinical signal that appeared more frequently in anterior uveitis was aqueous flare and in posterior uveitis were inactive lesions in the ocular fundus. In 68% of the cases, it was possible to identify the cause of uveitis. However, in 32% of the study population the cause remained unknown by conditioning in performing complementary diagnostic tests. Concerning uveitis etiology, 59% were due to systemic causes and 41% were due to ocular causes. The most frequently systemic causes were T. gondii (14,5%) and B. henselae (14,5%), and the most frequently ocular cause was trauma (17%). From this study it was possible to conclude that is very difficult to obtain a definitive etiologic diagnosis. The performance of a complete ophthalmic examination, as part of the physical routine examination, should always be done. It is essential that clinicians remain alert to various clinical presentation of feline uveitis, and treat the primary cause whenever possible or refer to a clinical specialist.
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Pires, Catarina Fernandes 1956. "Estudo do HLA-DR e HLA-DQ em pacientes piauienses com artrite idiópática juvenil." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312850.
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Orientador: Manoel Barros BertoloTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: O presente estudo de caso-controle avaliou 74 crianças piauienses com Artrite Idiopática Juvenil (AIJ) em suas diversas formas: Oligoarticular, Sistêmica, Poliarticular Fator Reumatoide Positivo (FR+), Poliarticular Fator Reumatoide Negativo (FR-), Artrite relacionada a Entesite (ERA), Artrite Psoriásica e Artrite indeterminada, classificadas de acordo com os Critérios da Liga Internacional de Associações de Reumatologia (ILAR) e cento e um controles saudáveis pareados de acordo com idade, sexo, procedência e etnia. Os objetivos foram identificar e determinar os alelos HLA-DR e HLA-DQ em uma amostra da população infanto-juvenil piauiense com AIJ nas formas oligoarticular, sistêmica, poliarticular FR+, poliarticular FR-, artrite psoriásica, artrite relacionada a entesite e artrite indeterminada e compará-las com as frequências observadas no grupo de controle saudáveis; conhecer os alelos HLA-DR e HLA-DQ que estão associados a maior susceptibilidade e os que conferem maior proteção na população de crianças com AIJ em suas diversas formas. As tipagens dos alelos HLA-DR e HLA-DQ foram realizadas por meio da técnica de amplificação pela Reação de Cadeia da Polimerase (PCR), utilizando cadeias específicas de primers DR e DQ. O resultado da análise demostrou que, entre todas as formas de apresentação da AIJ, houve associação estatística significativa para a susceptibilidade da doença com o HLA-DRB1*10 OR 8,8 (IC 1,1 a 74,9) e HLA-DRB1*16 OR 2,8 (IC 1,1 a 7.5). Na forma oligoarticular a associação estatística significativa para a susceptibilidade ocorreu com o alelo HLA-DRB1*08 OR 4,6 (IC 1,4 a 14,6). Na forma sistêmica, essa associação aconteceu com o alelo HLA-DRB1*10 OR 22,2 (IC 1,8 a 269,5).Na forma Poliarticular FR+ a associação estatística significativa para a susceptibilidade ocorreu com os alelos DRB1*09 OR 12,1 (IC 2,2 a 66,9) e DRB1*10 OR 28,5 (IC 2,3 a 355,0). Na forma Poliarticular FR-, a associação estatística significativa para a susceptibilidade foi com o alelo DRB1*16 OR 13,4 (IC 1,6 a 111,2). A Artrite Psoriásica não apresentou nenhuma associação estatística significativa com os HLA pesquisados. O resultado da análise demostrou que, entre todas as formas de apresentação da AIJ, houve associação estatística significativa para a proteção da doença com o HLA-DRB1*03 OR 0,7 (IC 0,5 a 0,9) e, na forma sistêmica, essa associação aconteceu igualmente com DRB1*03 OR 0,7 (IC 0,6 a 0,8). As outras formas de apresentação da doença não demonstraram associação estatística significativa para a proteção com nenhum tipo da HLA pesquisado. A população estudada não apresentou nenhum caso de ERA e de Artrite indeterminada. O estudo encontrou ainda, associação para o risco entre o HLA-DQB1*03 OR = 6,06 (IC 1,3 a 27,2) e uveíte em pacientes com a forma oligoarticular da AIJ. Desta forma, concluímos que os nossos resultados apresentam tanto semelhanças em relação a susceptibilidade, quanto diferenças, principalmente quanto a proteção, nas associações tipicamente encontradas na literatura
Abstract: This case-controle valuated 74 children from Piauí with Juvenile Idiopathic Arthritis (AIJ) in its various forms: Oligoarticular, Systemic, Polyarticular Rheumatoid Factor Positive (FR +), Polyarticular Rheumatoid Factor Negative (FR-), Enthesitis-related Arthritis (ERA), Arthritis Psoriatic and Arthritis indeterminate, classified according to the Criteria of the International League of Associations for Rheumatology(ILAR), and one hundred and one healthy control smatched according to age ,sex, origin and ethnicity. The objectives were to identify and determine the HLA-DR and HLA-DQ in a sample of Piauí juvenile population subtypes JIA in oligoarticular, systemic, polyarticular RF + polyarticular RF -, psoriatic arthritis, enthesitis-related arthritis and arthritis indeterminate and compares them with the observed frequencies in the group of healthy control; know the HLA-DR and HLA-DQ alleles are associated with increased susceptibility and conferring greater protection in the population with JIA in its various forms and identify a possible relationship between the alleles HLA-DR and HLA-DQ and the most frequent and most aggressive form of the disease in the population studied. Polymerase Chain Reaction (PCR) using primers specific chains of DR and DQ performed the typing of HLA-DR and HLA-DQ using the technique of amplification. The result of the analysis demonstrate damong all cases of JIA was statistically significant association for disease susceptibility with HLA-DRB1*10 OR 8.8 (CI 1.1 to 74.9) and HLA-DRB1*16 OR 2.8 (CI 1.1 to 7.5). In oligoarticular JIA significant statistical association to susceptibility occurred with HLA-DRB1*08 allele OR 4.6 (CI 1.4 to 14.6), association systemic form happened to HLA-DRB1*10 OR 22.2 (CI 1.8 to 269.5) allele in polyarticular RF + the statistically significant association to susceptibility occurred with the DRB1*09 alleles OR 12.1(CI 2.2 to 66.9) and DRB1*10 OR 28.5(CI 2.3 to 355.0) in polyarticular RF- significant statistical association to susceptibility was with DRB1*16 allele OR 13.4 (CI 1.6 to 111.2). The Psoriatic Arthritis showed no statistically significant association with HLA surveyed. The result of the analysis demonstrate damong all cases of JIA was statistically significant association for disease protection with HLA-DRB1*03 OR 0.7(CI 0.5 to 0.9) and the systemic form this association also happened DRB1*03 OR with 0.7 (CI 0.6 to 0.8). The other forms of the disease showed no statistically significant association for protection on any type of HLA searched. The study population did not show any cases of ERA and indeterminate Arthritis. The study also found, statistically significant difference between the HLA-DQB1*03 OR 6.0 (CI 1.3 to 27.2), and uveitis in patients with oligoarticular form of JIA. Thus, we conclude that our results show both similarities in terms of susceptibility, and differences, especially regarding the protection, associations typically found in the literature
Doutorado
Medicina Interna
Doutora em Ciências Médicas
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Stuckey, Jane Ashley. "Preliminary analysis of ophthalmic prednisolone acetate and diclofenac on diabetes mellitus regulation in 12 of 40 dogs." Thesis, Kansas State University, 2014. http://hdl.handle.net/2097/17395.
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Master of ScienceDepartment of Clinical Sciences
Amy Rankin
Objective- To evaluate the use of a topical ophthalmic steroid (1% prednisolone acetate) and non-steroidal anti-inflammatory drug (0.1% diclofenac) on blood glucose concentrations, serum fructosamine concentrations, and clinical scores in diabetic dogs with cataracts using descriptive analysis. Animals- Twelve client-owned dogs with naturally-occurring, controlled (per history and physical examination), insulin-treated diabetes mellitus and cataract. A total of 40 dogs will be enrolled in the study, as determined by power analysis. Procedures- This was a prospective, randomized, double-masked, experimental study with 2 phases of data collection. Dogs were enrolled from October 2011 to March 2014 and were assigned to 1 of 2 treatments (Drug Red or Drug Blue) using blocked randomization; dogs received either 1% prednisolone acetate suspension or 0.1% diclofenac solution. Patient history, physical, and ophthalmic examinations were performed and a clinical score assigned at enrollment (Phase 1 [day 0]) and upon return (Phase 2 [day 32]). At these times, a complete blood count, serum chemistry, urinalysis, and serum fructosamine concentration were performed prior to hospitalization for up to 72 hours for continuous glucose monitoring. For 4 weeks (day 3 to 31), dogs returned home, and owners administered the dispensed ophthalmic medication 4 times daily to both eyes. Descriptive analysis of data was performed; statistical analysis will follow enrollment of 40 dogs. Results- Twelve dogs have completed the study, with 6 dogs assigned to each treatment group. Dogs received 4.44 or 0.44 mg/day of prednisolone acetate or diclofenac, respectively. Dogs assigned to Drug Red more commonly exhibited elevations in serum liver enzyme activity. Drug Red group showed a greater percent increase in fructosamine concentrations over time. Based on glucose curves alone (22 curves analyzed), an insulin dose increase was recommended for 12 curves. An insulin dose decrease and no dose change were recommended for 5 curves each. During treatment, 1 dog reportedly developed polyuria and polydipsia. Conclusions- Descriptive analysis revealed differences in some outcomes of interest among dogs treated with 2 different ophthalmic anti-inflammatory medications. Data collection is ongoing to determine if statistically significant differences exists for outcomes per group.
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Schmalzl, Thomas Benedikt. "Charakterisierung des Autoantigens "mitochondriale Malat-Dehydrogenase" bei der equinen rezidivierenden Uveitis." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-36151.
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Zipplies, Johanna. "Differenziell exprimierte Proteine im Serum von Pferden mit equiner rezidivierender Uveitis." Diss., lmu, 2008. http://nbn-resolving.de/urn:nbn:de:bvb:19-91713.
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Roth, Therese. "Histologische Untersuchungen des Glaskörpers bei an equiner rezidivierender Uveitis erkrankten Pferden." Diss., Ludwig-Maximilians-Universität München, 2013. http://nbn-resolving.de/urn:nbn:de:bvb:19-157806.
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Barton, Keith. "Experimental studies of T lymphocytes in the retina in posterior uveitis." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282034.
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Menezo, V. "The genetic predictors of severe outcome in patients with anterior uveitis." Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1334585/.
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Uveitis is a generic term for a wide variety of different types of intraocular inflammation with different clinical phenotypes and visual outcomes. The explanation for why some patients develop chronic anterior disease whereas others do not is unknown. It seems likely that host factors such as the cytokine milieu of the aqueous humor may be an important factor in determining outcome. In turn, their secretion is genetically determined and cytokine gene polymorphisms have been associated with high or low level production whatever the stimulus. Purpose: The aim of this study was to identify key cytokine and chemokine polymorphisms associated with disease susceptibility, clinical phenotype, and development of visually significant complications in patients with anterior uveitis. Methods: PCR amplification was used to genotype a number of biallelic SNPs in several cytokine genes. This genetic data was then compared between patients and healthy controls, and within the patient group itself for association with clinical disease outcomes. Results: Our results show that a significant difference in the frequency of TNF-857T allele in patients with idiopathic anterior uveitis. We found a significant association between TNF-308 allele G and patients with anterior uveitis who were HLA-B27 positive. Patients with HLA-B27 associated anterior uveitis who developed visually threatening complications were more likely to carry the TNFRSF1A-201T or TNFRSF1A-1135T alleles. In addition, the frequency of IL- 1ra allele T was found to be significantly associated with chronicity of the disease. The frequency of MCP-1 (-2076T) allele was found to be significantly higher in healthy individuals when compared to patients with acute idiopathic anterior uveitis. Conclusions: These results suggest that genetic variations in proinflammatory mediators may influence the susceptibility and severity of the inflammatory response in eyes of patients with anterior uveitis. This knowledge may be useful in identifying prognosis and responsiveness to anti-TNF blockade in patients with anterior uveitis.
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Ahad, M. A. "Genetics of chemokines & cytokines in non-infectious posterior segment uveitis." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1399524/.
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Background and Aims: Non-infectious posterior segment uveitis is a potentially blinding disease that usually affects people of working age group. Like other immune mediated diseases, uveitis is a complex polygenic disease. Several cytokines have been identified as important regulators of the immune system during, induction, progression and remission of ocular inflammation in uveitis. The work described in this thesis is based on the hypothesis that polymorphisms in chemokine and cytokine genes can predict clinical outcome in non-infectious uveitis. Methods: Functional polymorphisms in sixteen chemokine and cytokine genes were genotyped and there associations were studied in a cohort of British Caucasians suffering with non-infectious posterior segment uveitis. Results: This study has shown that polymorphisms in IL-18, IL-10 & CCR2 genes can influence the susceptibility to certain phenotypes of non-infectious uveitis. Polymorphisms in many genes particularly, IL-1 , IL-6, CCR5 & IL-18 are found to affect the visual outcome and severity of the disease. Conclusion: The identification of these genetic variants that add susceptibility or resistance to uveitis has provided us further insights into the pathogenesis of uveitis. This work will help us identify patients who are at a greater risk of losing sight with this disease. This, in turn would allow tailored aggressive therapy to be given at presentation when vision is still good with a precise aim to prevent significant amount of blindness.
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Yermalitski, Anton [Verfasser]. "Fuchs Uveitis - Klinische Befunde bei einem virusassoziierten Krankheitsbild / Anton V. Yermalitski." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1148425136/34.
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Hoey, Sharon. "Cytokine-induced nitric oxide mediates tissue damage in experimental autoimmune uveitis." Thesis, University of Aberdeen, 1999. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602036.
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The large amounts of nitric oxide (NO) produced by the inducible nitric oxide synthase (iNOS) has been described as a double-edged sword eliciting pro- or anti inflammatory effects in different immune situations. The aim of this study was to investigate the role of NO in ocular inflammation. Rat RPE cells were shown to produce NO in vitro in response to inflammatory stimuli but in vivo the RPE expressed little or no iNOS enzyme in the normal Lewis rat eye. However, expression of the iNOS enzyme was closely associated with disease activity in experimental autoimmune uveoretinitis (EAU), a model of ocular inflammation, induced in the Lewis rat following a single footpad injection of retinal antigens. iNOS was predominantly expressed by EDl+ macrophages, infiltrating the rod outer segments and lytic lesions across the retina, during the acute inflammatory stages of EAU. Immunoreactivity to iNOS corresponded with increased urinary NO metabolite (NOJ levels, peak clinical disease, maximum choroidoretinal infiltration, upregulated iNOS mRNA expression and the induction and upregulation of IFN-gamma mRNA expression. Moreover, treating immunised animals with modulators of the L- arginine:NO pathway altered both NO excretion and the pathogenesis of EAU. Increasing the levels of L-arginine increased urinary NO levels, accelerated the inflammatory response and increased disease severity whereas treatment with the NOS inhibitor, N -nitro-L-arginine methyl ester (L-NAME), reduced NO excretion, delayed the onset and reduced the clinical signs of EAU.iNOS mRNA was detected at all stages of disease and expression was upregulated during peak disease activity. L-arginine treatment enhanced cytokine mRNA expression, particularly of IFN-gamma, which was detected earlier than in control animals, corresponding with the more rapid onset of disease and increased disease severity observed in this group. L-NAME had little or no effect on iNOS or inflammatory cytokine mRNA expression. This study suggests that NO mediates tissue damage in EAU and highlights the importance of the macrophage as an effector cell in what is considered a CD4+ T cell-dependent disease. iNOS was also detected in the normal human retina. As the role of iNOS in the pathogenesis of ocular disease in man is revealed then the therapeutic potential of NOS inhibitors, particularly with the development of iNOS specific inhibitors, in the treatment of inflammatory and autoimmune-mediated disease can be assessed.
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Zipplies, Johanna Katrin. "Differenziell exprimierte Proteine im Serum von Pferden mit equiner rezidivierender Uveitis." kostenfrei, 2008. http://edoc.ub.uni-muenchen.de/9171/.
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Yermalitski, Anton V. [Verfasser]. "Fuchs Uveitis - Klinische Befunde bei einem virusassoziierten Krankheitsbild / Anton V. Yermalitski." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2017. http://d-nb.info/1148425136/34.
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劉韋形 and Wai-ying Winnie Lau. "Characteristics of uveitis in juvenile idiopathic arthritis patients in a screening program in Hong Kong." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41710599.
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Klaska, Izabela. "Dendritic cell-based therapy of experimental autoimmune uveoretinitis." Thesis, University of Aberdeen, 2013. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=196130.
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Recently, there has been considerable interest in developing specific cell-based immunotherapies using dendritic cells (DCs). Here the mechanisms underlying the tolerogenic properties of DCs in the suppression of experimental autoimmune uveoretinitis (EAU), the mouse model of human sight threatening autoimmune uveitis, were examined. Immature DCs have the ability to promote immune tolerance to self antigens and to prevent the development of autoimmune disorders including EAU. However there is a risk that immature DCs placed in the inflammatory environment would undergo maturation and instead of tolerance promote immunity. Therefore much effort has been directed to develop protocols that stabilize the tolerogenic DC properties which would ultimately ensure safety and effectiveness of DC-based vaccines. Previous work demonstrated that activation of DCs with lipopolysaccharide (LPS) increases the ability of these cells to prevent EAU. Here, it was demonstrated that LPS promotes the activation of both TRIF and MyD88 signalling pathways in DCs which after 24 h LPS treatment secreted a significant amount of IL-10, IFN-β, IL-1β, IL-6 and TNF-α while the level of secreted IL-12 is low. It was further shown that LPSinduced enhancement of the tolerogenic properties of DCs correlates with the state of endotoxin tolerance in the DCs, rendering them refractory to further stimulation. It was hypothesised that the LPS-induced enhancement of DC tolerogenicity is due to the reduced expression of the TLR4, which subsequently disables several signalling pathways and prevent DCs from initiating adaptive T cell immunity. In summary, the presented data provides valuable insights into the mechanisms involved in the suppression of autoimmune uveitis using a DC-based therapy.
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Lau, Wai-ying Winnie. "Characteristics of uveitis in juvenile idiopathic arthritis patients in a screening program in Hong Kong." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B41710599.
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