To see the other types of publications on this topic, follow the link: Uteru.
Journal articles on the topic 'Uteru'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Uteru.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Hospes, R., H. Bostedt, L. F. Litzke, and C. Jung. "Operative Behandlung der Torsio uteri ante partum bei Stuten unter Erhalt der Gravidität." Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 35, no. 01 (2007): 45–54. http://dx.doi.org/10.1055/s-0037-1621516.
Full textAbstract:
Zusammenfassung Gegenstand und Ziel: Der Zustand einer Torsio uteri ante partum bei der Stute wird vorwiegend durch operative Retorsion unter gleichzeitiger Entfernung des Fetus mittels Hysterotomie behoben. Diese Vorgehensweise birgt jedoch das hohe Risiko der Entwicklung einer prämaturen und häufig noch nicht lebensfähigen Frucht sowie das der Nachgeburtsverhaltung mit den daraus resultierenden Konsequenzen. Die Studie ging der Frage nach, ob eine Belassung des Fohlens in utero nach Retorsion des Uterus nicht vorteilhafter ist. Material und Methoden: Das Patientenkollektiv setzte sich aus 23 Stuten verschiedener Rassen im Alter zwischen drei und 16 Jahren (10,5 ± 4,0) mit Torsio uteri ante partum zusammen. Die Stuten befanden sich zwischen dem fünften und 11. Monat (8,7 ± 1,9) der Gravidität. Bei allen Patienten wurde unter Allgemeinanästhesie eine ventromediane Laparotomie durchgeführt. Nach Exploration der Bauchhöhle und intraabdominaler Orientierung erfolgte die Retorsion des Uterus. Bei positivem Befund der fetalen Reflexe wurde das Fohlen in utero belassen und die Stute postoperativ hinsichtlich des Erhaltes der Gravidität intensiv therapiert. Ergebnisse: Zwei der 23 Stuten mussten in tabula wegen einer Magenruptur bzw. massiven, torsionsbedingten Alterationen des Uterus und der Adnexe euthanasiert werden. Bei zwei weiteren Stuten führte die Operation nicht zum gewünschten Erfolg. Sie entwickelten postoperativ eine Peritonitis respektive eine Typhlokolitis. Von den verbliebenen 19 Stuten gebaren 17 termingerecht vitale Fohlen, die sich komplikationslos weiterentwickelten. Zwei Stuten abortierten am dritten Tag respektive drei Monate post operationem. Schlussfolgerungen und klinische Relevanz: Die Ergebnisse der Studie belegen, dass bei Stuten mit einer Torsio uteri ante partum mit zum Zeitpunkt der Operation noch lebendem Fetus das Belassen der Frucht nach Retorsion des Uterus sinnvoll ist. In einem hohen Prozentsatz lässt sich bei den Stuten die Gravidität erhalten und mit einer termingerechten Geburt eines vitalen, maturen Fohlens beenden.
2
Elisa, Elisa, Luluk Dwi Royani, and Wien Sulistyo Adi. "Pengaruh Masase Fundus Uteri Dengan Pendidikan Kesehatan (Video Masase Fundus Uteri) Terhadap Penurunan Tinggi Fundus Uteri Ibu Postpartum Di RSUD Pandan Arang Boyolali." Jurnal Ilmu Keperawatan Maternitas 1, no. 2 (December 10, 2018): 15. http://dx.doi.org/10.32584/jikm.v1i2.145.
Full textAbstract:
Di dalam masa postpartum terdapat suatu proses yang disebut dengan proses involusi uteri atau kembalinya uterus ke keadaan normal atau sebelum hamil. Secara normal penurunan tinggi fundus uteri turun 1 cm setiap harinya, dan pada hari ke 7 postpartum tinggi fundus uteri berada pada ketinggian 5 cm, untuk mempercepat proses penurunan tinggi fundus uteri dapat dilakukan dengan masase fundus uteri. Untuk itu peneliti ini bertujuan untuk mengetahui adakah pengaruh masase fundus uteri dengan pendidikan kesehatan (video masase fundus uteri) terhadap penurunan tinggi fundus uteri pada ibu postpartum di RSUD Pandan Arang Boyolali. Jenis penelitian yang digunakan adalah quasi exsperiment dengan rancangan post test only and with control grup design. Penelitian ini dilakukan pada 30 responden dengan teknik consecutive sampling. Selanjutnya data penelitian di analisa menggunakan uji Mann-Whitney. Hasil penelitian didapatkan mean rank kelompok perlakuan 8,73 dan kelompok kontrol 22,27 dengan p value 0,000 (<0.05) dapat disimpulkan ada pengaruh masase fundus uterui dengan pendidikan kesehatan menggunakan video masase fundus uteri terhadap penurunan tinggi fundus uteri.
3
Martin, J. Ryan, Sarah B. Lieber, James McGrath, Marya Shanabrough, Tamas L. Horvath, and Hugh S. Taylor. "Maternal Ghrelin Deficiency Compromises Reproduction in Female Progeny through Altered Uterine Developmental Programming." Endocrinology 152, no. 5 (February 15, 2011): 2060–66. http://dx.doi.org/10.1210/en.2010-1485.
Full textAbstract:
Ghrelin has a well-known role in the regulation of appetite, satiety, energy metabolism, and reproduction; however ghrelin has not been implicated in reproductive tract development. We examined the effect of ghrelin deficiency on the developmental programming of female fertility. We observed that female wild-type mice born of ghrelin heterozygote dams (i.e. exposed in utero to ghrelin deficiency) had diminished fertility and produced smaller litters. We demonstrate that exposure to in utero ghrelin deficiency led to altered developmental programming of the reproductive tract. The number of ovarian follicles, corpora lutea, and embryos produced were identical in both exposed and unexposed mice. However wild-type embryos transferred to uteri of mice exposed to in utero ghrelin deficiency had a 60% reduction in the rate of embryo implantation compared with those transferred to wild-type unexposed uteri. We identified significant alterations in the uterine expression of four genes critical for implantation and a defect in uterine endometrial proliferation. Taken together, these results demonstrate that the mechanism of subfertility was abnormal endometrial function. In utero exposure to decreased levels of ghrelin led to defects in developmental programming of the uterus and subsequent subfertility in wild-type offspring.
4
Oktaviani, Anisa Sevi. "SWEDISH MASSAGE THERAPY UPAYA PERCEPATAN INVOLUSI UTERI PADA IBU POSPARTUM DI WILAYAH CILACAP KOTA." Jurnal Kebidanan 12, no. 01 (June 14, 2020): 103. http://dx.doi.org/10.35872/jurkeb.v12i01.369.
Full textAbstract:
ABSTRAKLatar Belakang Masalah. Kegagalan involusi uterus untuk kembali pada keadaan tidak hamil akan menyebabkan sub involusi yang menyebabkan perdarahan masa postpartum. Angka Kematian Ibu karena perdarahan post partum mempunyai peringkat tertinggi dimana salah satu penyebab perdarahannya adalah subinvolusi uteri. Swedish Massage Therapy (SMT) mempertahankan kesehatan dan menambah baiknya fungsi tubuh, merangsang pengeluaran hormone endorphin yang melancarkan reflek let down untuk mengeluarkan hormon oksitosin. Tujuan penelitian untuk mengetahui pengaruh Swedish Massage Therapy (SMT) pada ibu pospartum sebagai upaya penatalaksanaan involusi uteri di wilayah Cilacap Kota. Metode: Studi eksperimental dengan Posttest Only Control Group Design. Alat yang digunakan dalam penelitian berupa metline. Diberikan perlakuan SMT pada kelompok intervensi dan tidak diberi perlakuan SMT pada kelompok kontrol, kemudian dilakukan pengukuran tinggi fundus uteri hari ke-3 dan hari ke-5. Pengambilan sampel menggunakan teknik incidental sampling sebesar 30 responden. Data dianalisis dengan uji Mann Whitney melalui program SPSS 20. Hasil penelitian. Terdapat perbedaan yang signifikan penurunan tinggi fundus uteri antara kedua kelompok pada hari ke-3 (p=0,31) dan hari ke 5 (p=0,33). Dari hasil penelitian dapat disimpulkan bahwa Swedish Massage Therapy (SMT) berpengaruh pada ibu postpartum sebagai upaya percepatan involusi uteri di wilayah Cilacap Kota. Kata Kunci: SMT, Involusi, Pospartum SWEDISH MASSAGE THERAPY ATTEMPTS TO ACCELERATE INVOLUTION OF UTERI IN THE POSPARTUM MOTHER REGION IN CILACAP CITYABSTRACTBackground problem. Failure of the involution of the uterus to return to the Unexpectant state will cause a sub involution that causes the bleeding of postpartum period. The maternal mortality rate of post-partum hemorrhage has the highest ranking in which one of the causes of the land is the uterine atony or the involution of utero. Swedish Massage Therapy (SMT) maintains health and augments body function, stimulating the production of endorphin hormone that launches a quick reflec let down to secrete oxytocin hormones. The research aims to determine the effect of the Swedish Massage Therapy (SMT) on the Pospartum mother as an effort to manage utero involution in Cilacap Kota. Methods: Experimental studies with Posttest Only Control Group Design. The tools used in the study of the Metline. Administered SMT treatment in the intervention group and was not given SMT treatment in the control group, then carried out the high measurement of Fundus utero Day 3 and day-5. Sampling using the incidental sampling technique of 30 respondents. The Data is analyzed by Mann Whitney test statistic through the SPSS 20 program. Research results. There is a significant difference in the high decline of utero fundus between the two groups on day 3 (P = 0.31) and day 5 (P = 0.33). From the results of the study can be concluded that the Swedish Massage Therapy (SMT) has an effect on the mother postpartum as an attempt to accelerate utero involution in the area of Cilacap Kota. Keywords: SMT, Involusi, Pospartum
5
Nurchairin, Nurchairina. "Hubungan Overdistensi Uterus dengan Kejadian Atonia Uteri pada Ibu Post Partum di Sebuah Rumah Sakit di Provinsi Lampung." Jurnal Ilmiah Keperawatan Sai Betik 13, no. 2 (July 30, 2018): 215. http://dx.doi.org/10.26630/jkep.v13i2.933.
Full textAbstract:
<p>Atonia uteri merupakan penyebab tersering terjadinya perdarahan post partum. Salah satu faktor predisposisi atonia uteri adalah overdistensi uterus. Masalah dalam penelitian ini adalah masih banyaknya kejadian atonia uteri. Penelitian ini merupakan penelitian analitik dengan pendekatan <em>case control</em>, yang bertujuan untuk mengetahui hubungan antara overdistensi uterus dengan kejadian Atonia uteri. Populasi penelitian ini semua ibu perdarahan post partum, dengan sampel kasus sebanyak 32 kasus /semua kasus, sedang sampel kontrol sebanyak 64 kasus (<em>simpel random sampling</em>). Pengumpulan data dilakukan dengan melihat catatan yang ada di medical record/ data sekunder. Analisis data univariat menggunakan prosentase dan bivariat dengan <em>chi Square</em>. Hasil penelitian didapatkan, umur beresiko pada kasus sebanyak 43,8 % (< 20 th dan > 35 th), sedang kontrol lebih sedikit yaitu 28,1 %. Atonia banyak terjadi pada multiparitas baik kasus maupun kontrol (75 %). Kondisi over distensi uterus (makrosomia , hidramnion, gamelli) lebih banyak didapatkan pada kasus (atonia uteri) dibandingkan dengan kelompok kontrol (bukan atonia uteri) yaitu 62,5 %. Responden yang mengalami atonia uteri ada sebanyak 31,2 % ibu yang bayinya makrosomia, 31,2 % ibu dengan hidramnion, 53,1% ibu yang melahirkan bayi gamelli dan 62,5 % ibu yang overdistensi uterus , sedang responden yang tidak mengalami atonia uteri ada sebanyak 7,8 % ibu yang bayinya makrosomia, 10,9 % ibu dengan hidramnion 21,9 % ibu yang melahirkan bayi gamelli dan 26,6 % ibu yang overdistensi uterus. Hubungan antara overdistensi uterus dengan atonia uteri didapatkan nilai p value 0,001 dan OR 4,608 (makrosomia p value 0,007 dan OR 5,364, hidramnion p value 0,030 dan OR 3,701, gamelli 0,004 dan OR 4,048), maka dapat disimpulkan ada hubungan yang signifikan antara makrosomia, hidramnion, gamelli dan overdistensi uterus dengan kejadian atonia uteri (α < 0,05) Saran kepada petugas kesehatan agar memberikan pelayanan secara intensif pada saat melakukan pertolongan persalinan dan memberikan pelayanan secara dini kepada ibu yang mempunyai resiko atonia uteri.</p>
6
Detti, Laura, Mary Emily Christiansen, Roberto Levi D’Ancona, Jennifer C. Gordon, Nicole Van de Velde, and Irene Peregrin-Alvarez. "Restoration of Uterine Cavity Measurements after Surgical Correction." Journal of Imaging 6, no. 7 (June 29, 2020): 58. http://dx.doi.org/10.3390/jimaging6070058.
Full textAbstract:
Objective: We sought to define the uterine and uterine cavity dimensions of subseptate uteri before and after hysteroscopic surgical incision, and compare them to those obtained in normal uteri with 3-D ultrasound. Methods: Two cohorts of consecutive women with normal-appearing uterine cavity and women diagnosed with uterine subseptations, before and after undergoing hysteroscopic incision. 3-D ultrasound was used to measure the uterine cavity width, length, and area on a frozen coronal view of the uterus. Results: A total of 215 women were included: 89 in the normal, and 126 in the subseptate uterus, groups. Uterine length and height were similar in the pre-operative, post-operative subseptate uteri, and in the normal uteri, while the uterine width was significantly greater in the pre-operative (5.1 + 0.8 cm) than post-operative (4.7 + 0.8 cm) and normal uterus (4.6 + 0.7 cm; p < 0.001) groups. The pre-operative uterine cavity length (3.3 + 0.5 cm), width (3.2 + 0.7 cm), and area (4.4 + 1.2 cm2), were significantly greater than the post-operative ones (length 2.9 + 0.4 cm; width 2.6 + 0.6 cm; area 3.7 + 0.8 cm; overall p < 0.001), and became similar to the dimensions of the normal uterus. Of the patients who subsequently conceived, 2.6% miscarried in the corrected subseptation group and 28.8% miscarried in the normal uterus group. Conclusions: We defined the ultrasound dimensions of the uterine cavity in subseptate uteri and their change after surgical correction. Uterine cavity length, width, and area show very little variability in adult normal uteri, while they are increased in uteri with a subseptation greater than 5.9 mm in length, and regain normal measurements after surgical correction.
7
Widiyanti, Endang Sri, and I. Gede Mega Putra. "Penanganan inversio uteri: sebuah tinjauan pustaka." Intisari Sains Medis 13, no. 1 (March 1, 2022): 136–42. http://dx.doi.org/10.15562/ism.v13i1.1262.
Full textAbstract:
Acute uterine inversion is a rare but life-threatening emergency in the field of obstetrics. The main signs and symptoms of acute uterine inversion are bleeding and shock. The accuracy and speed of diagnosis and case management will reduce morbidity and mortality due to uterine inversion. This literature review is expected to increase our knowledge as practitioners in dealing with uterine inversion cases. In principle, there are two goals for the treatment of acute uterine inversion, namely repositioning the uterus and treating the shock that occurs. The success of uterine inversion repositioning is highly dependent on the speed of early detection. The longer the uterus is inverted, the more difficult it will be to reposition it. There are several non-surgical techniques for repositioning the uterus, including: Johnson maneuver, Henderson and Alles maneuver, use of tocolytics, and repositioning with hydrostatic pressure. Surgical procedures can be performed abdominally, namely the Huntington's Procedure, with abdominal repositioning laparotomy and the Haultain's Procedure, with abdominal cervical repositioning-repositioning laparotomy. Kejadian inversio uteri akut merupakan kegawatdaruratan di bidang Obstetri yang jarang terjadi namun mengancam nyawa. Tanda dan gejala utama inversio uteri akut adalah perdarahan dan syok. Ketepatan dan kecepatan diagnosa dan penanganan kasus akan mengurangi morbiditas dan mortalitas akibat inversio uteri. Tinjauan pustaka ini diharapkan dapat menambah pengetahuan kita sebagai praktisi dalam menangani kasus inversio uteri. Pada prinsipnya ada dua tujuan penanganan inversio uteri akut, yaitu reposisi uterus dan penanganan syok yang terjadi. Keberhasilan reposisi inversio uteri sangat tergantung pada kecepatan deteksi dini. Semakin lama uterus terinversi akan semakin sulit melakukan reposisi. Terdapat beberapa teknik non-bedah untuk reposisi inversio uteri, antara lain: manuver Johnson, manuver Henderson dan Alles, penggunaan tokolitik, dan reposisi dengan tekanan hidrostatik. Prosedur pembedahan dapat dilakukan melalui abdominal, yaitu Prosedur Huntington, dengan laparotomi-reposisi melalui abdominal dan Prosedur Haultain, dengan laparotomi- insisi cincin servikalis-reposisi melalui abdominal.
8
Ahmaniyah, Ahmaniyah, and Widi Maulana Andrian. "Hubungan Inisiasi Menyusui Dini Terhadap Involusi Uterus Pada Ibu Postpartum." Jurnal Kebidanan 11, no. 2 (September 17, 2021): 56–62. http://dx.doi.org/10.35874/jib.v11i2.881.
Full textAbstract:
Involusi uteri menjadi salah satu aspek yang perlu dievaluasi pada masa nifas. Involusi uteri berperan penting dalam menekan pendarahan post partum dan kembalinya ukuran uterus menjadi fisiologis seperti kondisi normal sebelum hamil. Tujuan penelitian ini untuk mengetahui hubungan inisiasi menyusui dini terhadap kejadian involusi uterus pada ibu post partum di UPT Puskesmas Talango. Jenis penelitian ini adalah penelitian analitik korelasional dengan pendekatan cross sectional. Tehnik pengambilan sampel dengan purposive sampling sebanyak 41 ibu post partum. Analsis statistik menggunakan chi square pada derajat kemaknaan α = 0,05. Hasil penelitian menunjukkan bahwa sebagian besar (75,6%) ibu post partum yang melakukan inisiasi menyusui dini segera setelah lahir, mengalami kejadian involusi uterus secara normal, dengan hasil uji statistic chi square didapat hasil p value = 0,001(α<0,05) yang berarti ada hubungan inisiasi menyusui dini terhadap involusi uterus pada ibu post partum. Berdasarkan hasil penelitian disimpulkan bahwa ada hubungan Inisiasi Menyusui Dini dengan proses involusi uterus secara normal pada ibu post partum. Involusi uterus merupakan salah satu aspek yang sangat penting dikaji dan diupayakan untuk berjalan secara normal untuk mengurangi terjadinya komplikasi persalinan, yaitu salah satunya dengan melakukan inisiasi menyusui dini yang terbukti berhubungan dengan involusi uteri secara normal.
9
Susanti, Ellis, Yune Yohana, and Siti Hardini. "Perbandingan Hasil Pemeriksaan CA125 Dengan USG (Utrasonografi) Pada Mioma Uteri Di RSAB Harapan Kita Jakarta Barat." Anakes : Jurnal Ilmiah Analis Kesehatan 6, no. 1 (March 30, 2020): 49–55. http://dx.doi.org/10.37012/anakes.v6i1.355.
Full textAbstract:
Mioma uteri merupakan tumor jinak yang paling sering ditemukan di uterus. Meskipun mioma memiliki potensi untuk tumbuh menjadi ukuran yang besar, tetapi potensi mioma uteri untuk menjadi ganas sangat kecil. Berdasarkan banyaknya kasus mioma uteri dilakukan pemeriksaan awal USG dan CA125 di RSAB Harapan Kita maka peneliti ingin mengetahuin hasil pemeriksaan USG dan CA125 di RSAB Harapan Kita. Penelitian dilakukan dengan melihat data sekunder USG dan CA125 pada pasien Mioma Uteri di RSAB Harapan Kita periode tahun Januari 2017 – 2019. Hasil penelitian ditemukan data sebanyak 60 Mioma Uteri usia 20-55 tahun, terdiri dari pemeriksaan USG dan CA125 dengan hasil USG tampak miom dengan CA125 35 U/mL sebanyak 15 (25%) sampel, hasil USG tampak miom dengan CA125 35 U/mL sebanyak 15 (25%) sampel, hasil USG tampak miom dan uterus membesar dengan CA125 35 U/mL 10 (16.6%) sampel, hasil USG tampak miom dan uterus membesar dengan CA125 35 U/mL sebanyak 20 (33.4%) sampel. Dilanjutkan dengan melakukan uji normalitas menggunakan uji Shapiro-Wilkkarena didapat hasil Sig.0.000yang berarti data tidak berdistribusi normal karena harusnya nilai Sig.normal 0.05 maka harus dilakukan uji selanjutnya menggunakan uji Mann-Whitney. Dari uji Mann-Whitney didapat hasil signifikan sebesar .093atau 0,05. Hasil uji Mann-Whitneytersebut maka dapat dikatakan Ho diterima yang berarti tidak ada perbedaan yang signifikan hasil pemeriksaan CA125 dengan hasil USG Tampak Miom maupun Tampak Miom dan Uterus Membesar. Kata Kunci : Mioma Uteri, CA125, USG (Utrasonografi)
10
Retnowati, Dwi, and Novia Nastasia Devi. "Hubungan Paritas terhadap Penurunan Tinggi Fundus Uteri pada Ibu Post Partum di Wilayah Kerja Puskesmas Beji Kecamatan Boyolangu Kabupaten Tulungagung." Care Journal 2, no. 1 (January 3, 2023): 37–44. http://dx.doi.org/10.35584/carejournal.v2i1.127.
Full textAbstract:
Involusi atau pengerutan uterus merupakan suatu proses dimana uterus kembali kekondisi sebelum hamil. Pada ibu primipara kekuatan kontraksi uterus lebih tinggi dan teraba lebih keras, sedangkan pada ibu multipara kontraksi uterus berlangsung lebih lama sehingga dapat memberikan pengaruh terhadap proses involusi uterus. Tujuan penelitian mengetahui hubungan paritas terhadap penurunan Tinggi Fundus Uteri pada ibu postpartum di wilayah kerja Puskesmas Beji, Kecamatan Boyolangu, Kabupaten Tulungagung tahun 2018. Penelitian dilaksanakan tanggal 16 April-15 Mei 2018. Jenis penelitian observasional, dengan pendekatan cross sectional dan instrument penelitian berupa kuesioner dan observasi. Populasi penelitian semua ibu post partum di wilayah kerja Puskesmas Beji Kecamatan Boyolangu Kabupaten Tulungagung. Sampel diambil dengan teknik purposive sampling sejumlah 30 orang. Variabel independent paritas, variabel dependent penurunan tinggi fundus uteri. Data dianalisis dengan uji chi square. Hasil penelitian didapatkan sebagian besar dari responden adalah ibu multipara yaitu sebanyak 19 orang (63,4%) dan hampir seluruh responden penurunan TFU nya normal, yaitu sebanyak 28 orang (93,3%). Uji statistik chi square didapatkan P Value = 0,001 < 0,05 sehingga H1 diterima, yang berarti ada hubungan paritas terhadap penurunan Tinggi Fundus Uteri pada ibu postpartum di wilayah kerja Puskesmas Beji, Kecamatan Boyolangu, Kabupaten Tulungagung tahun 2018. Ibu yang usianya lebih tua dan sudah beberapa kali melahirkan banyak dipengaruhi oleh proses penuaan dimana mengalami perubahan metabolisme yaitu terjadi peningkatan jumlah lemak, penurunan otot, penurunan penyerapan lemak, protein, dan karbohidrat dan hal ini akan menghambat penurunan fundus uteri. Resiko yang terjadi pada kehamilan >5 kali seperti kontraksi uterus yang kurang maksimal
11
Yu, Haiming, Xiaoqing Zhou, Yujing Zhang, Kexin Wen, Zhengli Yan, Hu Fu, and Yongfei Zhu. "Flutamide induces uterus and ovary damage in the mouse via apoptosis and excessive autophagy of cells following triggering of the unfolded protein response." Reproduction, Fertility and Development 33, no. 7 (2021): 466. http://dx.doi.org/10.1071/rd20287.
Full textAbstract:
Intrauterine exposure to flutamide not only causes abnormal development of the reproductive organs in male offspring, but also damages ovaries and uteri. The unfolded protein response (UPR) is believed to play an important role in embryo development and teratogenic processes. In the present study, pregnant mice were administered either flutamide (300mg kg−1 day−1, p.o.) on an equivalent volume of soybean oil (control) on Days 12–18 of gestation. Eight weeks after birth, female offspring in the flutamide-treated group had a lower bodyweight and lower ovarian and uterine weights, but there was no significant difference in uterine and ovarian weights normalised by bodyweight between the flutamide-treated and control groups. Furthermore, histopathological changes were observed in all uteri and ovaries in the flutamide-treated group, with fewer and less-developed follicles in the ovaries. In both the uteri and ovaries, flutamide increased the expression of UPR members, although the expression of cell cycle-related genes remained unchanged compared with the control group. Flutamide increased the expression of all autophagy- and apoptosis-related genes evaluated in the uterus, as well as some in the ovary. The results suggest that the in utero exposure of mice to flutamide may contribute to uterine and ovarian damage in the offspring, with endoplasmic reticulum stress possibly triggered by the UPR leading to the induction of excessive autophagy and apoptosis.
12
Fauzi, Amir, Ratih Krisna, Hadrians Kesuma Putra, and Yurizka Sabrina. "Multigravida Post-Partum dengan Inversio Uteri Subakut Komplit yang Ditatalaksana Histerektomi Supraservikal Pervaginam." Indonesian Journal of Obstetrics & Gynecology Science 5, no. 2 (September 27, 2022): 303–8. http://dx.doi.org/10.24198/obgynia/v5n2.335.
Full textAbstract:
Inversio uteri adalah salah satu komplikasi persalinan dengan risiko kematian tinggi akibat perdarahan dan syok. Laporan ini menjelaskan mengenai presentasi dan manajemen kasus inversio uteri. Seorang wanita berusia 33 tahun, P4A0 post partum spontan di bidan hari ke 5 dirujuk ke RS Mohammad Hoesin dengan riwayat uterus yang ikut keluar saat persalinan, namun uterus dapat dimasukkan kembali. Tanda-tanda vital pasien dalam batas normal. Pada pemeriksaan abdomen didapatkan tinggi fundus uteri sulit dinilai. Pada saat dilakukan inspeksi terdapat benjolan berupa keseluruhan uterus yang terbalik keluar dari serviks. Pemeriksaan laboratorium menunjukkan penurunan kadar hemoglobin (9.1 g/dL) dan peningkatan kadar leukosit (10.34x103/mm2). Pada pemeriksaan USG tidak tampak uterus pada kavum pelvis dengan kesan yang sesuai dengan gambaran inversio komplit. Pasien dipasangkan kateter lalu diputuskan untuk histerektomi supraservikal pervaginam. Kemudian pada pasien dilakukan pemasangan tampon vagina, pemberian antibiotik, antifibrinolitik serta obat simptomatik dengan stabilisasi berupa cairan dan transfusi. Setelah dua hari, tampon dilepas dan pasien membaik tanpa adanya komplikasi.
13
Bandyopadhyay, Soma, and Manidip Pal. "Non-Descent Vaginal Hysterectomy - Analysis of 100 Cases." Asian Journal of Medical Sciences 3, no. 1 (February 18, 2013): 1–5. http://dx.doi.org/10.3126/ajms.v3i1.4471.
Full textAbstract:
OBJECTIVE: To evaluate the feasibility of performing vaginal hysterectomy for non-prolapsed uteri as primary route METHODS: 100 patients planned for hysterectomy for a wide range of indications like large uterus, cervix flushed with vagina, previous pelvic surgery were chosen for vaginal hysterectomy. Prerequisite were uterine size not more than 16 weeks, adequate vaginal access and good uterine mobility. Patients with utero-vaginal prolapse, complex adnexal mass and suspected malignancy were excluded. RESULTS: Majority were aged 35 – 45 years (77%) with 8 nullipara and 21 primipara. Commonest indication was fibroid (54%) and largest uterine size was 16 weeks. There were 79 patients with history of different pelvic surgeries. Different morcellation techniques were used in more than 10 weeks sized uteri. Adnexal surgeries were performed in 12 cases without difficulty. In uncomplicated cases average blood loss was 200 ml and operating time was 50 minutes. Most of the patients were discharged by 5th post operative day. Two patients were converted to abdominal route due to bladder injury and slippage of upper pedicle respectively. CONCLUSION: Experience and training can lead gynecologist to consider the vaginal approach as the standard route for hysterectomy.DOI: http://dx.doi.org/10.3126/ajms.v3i1.4471Asian Journal of Medical Sciences 3(2012) 1-5
14
Salle, B., P. Sergeant, A. Awada, V. Bied-Damon, P. Gaucherand, C. Boisson, S. Guibaud, M. Benchaib, and R. C. Rudigoz. "Uterus and endometrium: Transvaginal ultrasound studies of vascular and morphological changes in uteri exposed to diethylstilbestrol in utero." Human Reproduction 11, no. 11 (November 1, 1996): 2531–36. http://dx.doi.org/10.1093/oxfordjournals.humrep.a019153.
Full text
15
Hirota, Yasushi, Kristin E. Burnum, Nuray Acar, Gabriel A. Rabinovich, Takiko Daikoku, and Sudhansu K. Dey. "Galectin-1 Markedly Reduces the Incidence of Resorptions in Mice Missing Immunophilin FKBP52." Endocrinology 153, no. 5 (March 13, 2012): 2486–93. http://dx.doi.org/10.1210/en.2012-1035.
Full textAbstract:
Progesterone (P4) signaling is critical for pregnancy. We previously showed that immunopilin FK506 binding protein (FKBP)52 serves as a cochaperone to optimize progesterone receptor (PR) function in the uterus, and its deficiency leads to P4 resistance in a pregnancy stage-specific and genetic background-dependent manner in mice. In particular, sc placement of SILASTIC implants carrying P4 rescued implantation failure in CD1 Fkbp52−/− mice, but the resorption rate was substantially high at midgestation due to reduced P4 responsiveness. Because downstream targets of P4-FKBP52-PR signaling in the uterus to support pregnancy are not clearly understood, we performed proteomic analysis using Fkbp52−/−, PR-deficient (Pgr−/−), and wild-type (WT) uteri. We found that the expression of galectin-1 (Gal1), an evolutionarily conserved glycan-binding protein, was significantly down-regulated in both Fkbp52−/− and Pgr−/− uteri compared with WT uteri. During early gestation, Lgals1, which encodes Gal1, was distinctly expressed in stromal and decidual cells. Lgals1 expression was much lower in d 4 Fkbp52−/− uteri compared with WT uteri, and this reduction was reversed by P4 supplementation. More interestingly, concomitant supplementation of recombinant Gal1 significantly suppressed the high resorption rate and leukocyte infiltration at implantation sites in CD1 Fkbp52−/− females carrying P4 SILASTIC implants. These findings suggest that uterine Gal1 is an important downstream target of P4-FKBP52-PR signaling in the uterus to support P4 responsiveness during pregnancy.
16
Choi, Soyoung, Hyejin Shin, Haengseok Song, and Hyunjung Jade Lim. "Suppression of autophagic activation in the mouse uterus by estrogen and progesterone." Journal of Endocrinology 221, no. 1 (January 17, 2014): 39–50. http://dx.doi.org/10.1530/joe-13-0449.
Full textAbstract:
Autophagy is a major cellular catabolic pathway tightly associated with cell survival. The involvement of autophagy in the prolonged survival of blastocysts in the uterus is well established, and it was assumed that ovarian steroid hormones – progesterone (P4) and estrogens – have important roles in the regulation of autophagy. However, information is scarce regarding whether these hormones regulate autophagy in certain hormone-responsive cellular systems. In this study, we investigated the effects of estrogen and P4 on autophagic response in the uteri of pregnant mice and in ovariectomized (OVX) mice treated with hormones. During pregnancy, autophagic response is high on days 1 and 2 when the uterus shows an inflammatory response to mating, but it subsides around the time of implantation. Dexamethasone treatment to day 1 pregnant mice reduced autophagy in the uterus. In OVX mouse uteri, estrogen or P4 reduces autophagic response within 6 h. Glycogen content in OVX uteri was increased by 3-methyladenine treatment, suggesting that autophagy is involved in glycogen breakdown in the hormone-deprived uterus. The classical nuclear receptor antagonists, ICI 182 780 or mifepristone, lead to the recovery of the autophagic response in OVX uteri. The suppression of autophagy by 17β-estradiol is inversely correlated with the accumulation of phospho-mouse target of rapamycin, and rapamycin treatment is moderately effective in the upregulation of autophagic response in OVX mouse uteri. Collectively, this study establishes that the uterine autophagy is induced in hormone-derived environment and is suppressed by hormone treatment. Uterine autophagy may have multiple functions as a responsive mechanism to acute inflammation and as an energy provider by breaking down glycogen under hormone deprivation.
17
Sardjono, Michelle, and Sony Sugiharto. "Gambaran histopatologis kelainan jinak uterus pada wanita usia reproduksi di Laboratorium Patologi Anatomi Akurat Semarang tahun 2019-2020." Tarumanagara Medical Journal 3, no. 2 (November 1, 2021): 353–60. http://dx.doi.org/10.24912/tmj.v4i1.13729.
Full textAbstract:
Kelainan jinak uterus merupakan kasus yang paling umum ditemui pada wanita usia reproduksi, termasuk di Indonesia. Kasus tersebut jika tidak segera ditangani dengan terapi yang tepat dapat menimbulkan komplikasi dan morbiditas yang tinggi sehingga membutuhkan pemeriksaan histopatologis sebagai diagnosis pasti. Studi ini bertujuan untuk mengetahui gambaran histopatologis kelainan jinak uterus pada wanita usia reproduksi. Sampel data diambil dari Laboratorium Patologi Anatomi (PA) Akurat, Semarang dari periode tahun 2019-2020 dengan metode penelitian observasional menggunakan desain potong lintang. Hasil studi didapatkan 103 sampel kelainan jinak uterus dengan 6 gambaran histopatologis yaitu 22,3% kasus polip endometrium, leiomioma uteri dan polip serviks masing-masing sebanyak 20,4%, hiperplasia endometrium sebanyak 15,5%, adenomiosis sebanyak 12,7%, dan endometritis sebanyak 8,8%. Berdasarkan hasil studi dapat disimpulkan gambaran histopatologis kelainan jinak uterus yang ditemukan pada wanita usia reproduksi di Laboratorium PA Akurat Semarang tahun 2019-2020 adalah polip endometrium, leiomioma uteri, polip serviks, hiperplasia endometrium, adenomiosis dan endometritis dengan kasus terbanyak adalah polip endometrium. Setiap kasus kelainan jinak uterus disarankan untuk dilakukan pemeriksaan histopatologi untuk dapat menentukan terapi yang tepat.
18
Appelbaum, Alan H., Mehran Tirandaz, Giuseppe Ricci, and Roberto Levi D’Ancona. "Alignment of the Cervix with the Vagina in Uterine Retroversion: A Possible Risk Factor in Uterine Prolapse." Diagnostics 12, no. 6 (June 9, 2022): 1428. http://dx.doi.org/10.3390/diagnostics12061428.
Full textAbstract:
Multiple observational studies have found an association of uterine prolapse with uterine retroversion. Mechanisms proposed to explain this apparent association assume that the cervix of a retroverted uterus will usually insert at the apex of the vagina, with resultant alignment of the cervix with the vagina. The angle of the axis of the cervix with the axis of the vagina was measured by two readers on 323 sagittal pelvic MRI scans and sagittal reconstructions of pelvic CT scans performed for clinical purposes. One reader observed and recorded the anatomic relations of the uterus that differed by insertion site and version: 44 of 49 retroverted uteri (89.8%) inserted at the vaginal apex, and 13 of 274 anteverted uteri (4.7%) inserted at the vaginal apex. This difference was found to be statistically significant (p < 0.05) by the Chi square test. The urinary bladder, vaginal walls, and rectum were inferiorly related to anteriorly inserted anteverted uteri. Only the vaginal lumen and the rectum at a shallow oblique angle were inferiorly related to apically inserted retroverted uteri. Most retroverted uteri insert at the apex of the vagina. Apically inserted retroverted uteri appear to receive less support from adjacent structures than anteriorly inserted anteverted uteri.
19
Nancye, Pandeirot, Hendro Djoko Tjahjono, and Setyoningsih Retno. "EFEKTIFITAS MENYUSUI TERHADAP PERCEPATAN PENURUNAN TINGGI FUNDUS UTERI PADA IBU POST PARTUM DI PETERONGAN - JOMBANG." Jurnal Kebidanan 10, no. 2 (November 24, 2021): 12–22. http://dx.doi.org/10.47560/keb.v10i2.287.
Full textAbstract:
Menyusui merupakan suatu pengetahuan yang selama berjuta-juta tahun mempunyai peran yang penting dalam mempertahankan kehidupan manusia. Ibu yang menyusui bayinya akan memperoleh manfaat yaitu penurunan tinggi fundus uteri yang lebih cepat. Sedangkan di masyarakat masih banyak di jumpai ibu-ibu yang tidak menyusui. Tujuan penelitian ini untuk mengetahui pengaruh menyusui terhadap percepatan penurunan tinggi fundus uteri pada ibu post partum hari ketiga. Desain penelitian pre eksperimental, pre test and post test group design. Sampel penelitian adalah ibu postpartum di BPS Ny. Umi Salamah Peterongan Jombang berjumlah 15 orang. Metode sampling yang digunakan adalah non probability sampling. Data dikumpulkan melalui observasi. Analisis data menggunakan uji Wilcoxon Signed Rank Test dengan derajat kemaknaan p<0,05. Hasil Hasil menunjukkan ada pengaruh anntara menyusui dengan penurunan tinggi fundus uteri. Dari hasil penelitian ibu post partum yang menyusui akan mempunyai penurunan tinggi uteri lebih cepat. Karena dengan menyusui akan membuat hormone oksitoksin berkerja dan menyebabkan kontraksi pada uterus sehingga uterus dapat kembali pada kondisi semula atau sebelum hamil.
20
AKHTAR, YASMEEN. "RUPTURED UTERUS." Professional Medical Journal 17, no. 02 (June 10, 2010): 314–17. http://dx.doi.org/10.29309/tpmj/2010.17.02.2439.
Full textAbstract:
Objective: To analyze the risk factors for uterine rupture and to share the 5 years experience of ruptured uterus with other colleagues of the specialty. Study design: Case series descriptive study. Settings: Gynae /Obstetrics Unit -I Lady Willingdon Hospital Lahore. Study Duration: Five years i.e Ist May 2004 to 30th April 2009. Material and Methods: Obstetric patients who presented with ruptured uteri. Results: Results showed that risk factor for ruptured uteri include cesarean sections (61.11%), grand multiparty (16.6%), Instrumentaldeliveries (4.44%) and undetected perforation (1.11%). Conclusion: Ruptured uterus is a high risk category of patients. The patients with previous scar, grand multiparas, obstructed prolonged labour must be managed by proper trained personnel and in tertiary care centers in order to avoid the morbidity or mortality due to ruptured uterus.
21
Klein, C., and A. Wehrend. "Lichtmikroskopische Untersuchungen am Uterus von Kühen mit Torsio uteri um 360°." Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 34, no. 05 (2006): 289–94. http://dx.doi.org/10.1055/s-0037-1621082.
Full textAbstract:
Zusammenfassung: Ziel: Histologische Darstellung der Gewebsveränderungen am Uterus bei Kühen mit Torsio uteri um 360°. Material und Methode: Im Rahmen einer Sectio caesarea wurde von drei Kühen mit einerTorsio uteri um 360° sowie von drei Tieren ohne Torsio uteri, bei denen die Operation wegen eines relativ zu großen Kalbes durchgeführt werden musste, Uterusgewebe entnommen und nach HE-Färbung lichtmikroskopisch untersucht. Ergebnisse: Beiden Kühen mit Torsio uteri zeigte sich im Vergleich zu Tieren ohne Gebärmutterdrehung eine Zunahme der Uteruswandstärke. Die statistische Analyse ergab dabei einen hochsignifikanten Unterschied in der Breite der Lamina propria mucosae, des Stratum musculare longitudinale und circulare (p < 0,0001). Des Weiteren waren die Gefäße des Stratum vasculosum im Vergleich zu Tieren ohne Torsio uteri massiv dilatiert und es lag ein hochgradiges Ödem der bindegewebigen Anteile des Stratum vasculosum vor, das sich auf dieinder äußeren Längsmuskelschicht lokalisierten Bindegewebszügefortsetzte. Bei Tieren mit Drehung der Gebärmutter bestand eine vollständige Ablösung des Oberflächenepithels. Bei beiden Gruppen konnten Bakterien in den Gewebeschnitten und eine Infiltration der Lamina propria mucosae mit neutrophilen Granulozyten beobachtet werden. Klinische Relevanz: Die Veränderungen der Uteruswand erklären die schwierige Adaptation der Hysterotomiewunde bei Tieren nach Torsio uteri. Darüber hinaus stellen sie eine mögliche Erklärung fürdie verringerte Fruchtbarkeit bei Kühen nach hochgradiger Torsion des Uterus dar.
22
Kelleher, Andrew M., Wang Peng, James K. Pru, Cindy A. Pru, Francesco J. DeMayo, and Thomas E. Spencer. "Forkhead box a2 (FOXA2) is essential for uterine function and fertility." Proceedings of the National Academy of Sciences 114, no. 6 (January 3, 2017): E1018—E1026. http://dx.doi.org/10.1073/pnas.1618433114.
Full textAbstract:
Establishment of pregnancy is a critical event, and failure of embryo implantation and stromal decidualization in the uterus contribute to significant numbers of pregnancy losses in women. Glands of the uterus are essential for establishment of pregnancy in mice and likely in humans. Forkhead box a2 (FOXA2) is a transcription factor expressed specifically in the glands of the uterus and is a critical regulator of postnatal uterine gland differentiation in mice. In this study, we conditionally deleted FOXA2 in the adult mouse uterus using the lactotransferrin Cre (Ltf-Cre) model and in the neonatal mouse uterus using the progesterone receptor Cre (Pgr-Cre) model. The uteri of adult FOXA2-deleted mice were morphologically normal and contained glands, whereas the uteri of neonatal FOXA2-deleted mice were completely aglandular. Notably, adult FOXA2-deleted mice are completely infertile because of defects in blastocyst implantation and stromal cell decidualization. Leukemia inhibitory factor (LIF), a critical implantation factor of uterine gland origin, was not expressed during early pregnancy in adult FOXA2-deleted mice. Intriguingly, i.p. injections of LIF initiated blastocyst implantation in the uteri of both gland-containing and glandless adult FOXA2-deleted mice. Although pregnancy was rescued by LIF and was maintained to term in uterine gland-containing adult FOXA2-deleted mice, pregnancy failed by day 10 in neonatal FOXA2-deleted mice lacking uterine glands. These studies reveal a previously unrecognized role for FOXA2 in regulation of adult uterine function and fertility and provide original evidence that uterine glands and, by inference, their secretions play important roles in blastocyst implantation and stromal cell decidualization.
23
E., Mapatano Shalamba, Kalala Kanyinda L., Kiminyi Kalunga M., Nyakio Ngeleza O., Kanku Tudiakwile L., and Mukwege Mukengere D. "About a uni-cervical unicorn uterus case with vaginal septum." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 9, no. 1 (December 26, 2019): 404. http://dx.doi.org/10.18203/2320-1770.ijrcog20196055.
Full textAbstract:
The unicorn uterus is a common uterine malformation after septate uteri, accounting for 30 to 50% of cases. We report a case of unicorn uterus with an associated vaginal septum discovered during the obstetrical examination of a consultant surgeon for hemorrhage, and exploration of the uterus revealed a uterus during a cesarean section. Maternal-fetal rescue for placenta previa. The interest of this case is to show the double embryological mechanism involved, unilateral aplasia of the muller ducts and the lack of resorption explaining this vaginal septum.
24
Lakhani, Payal D. "A novel and effective technique to exteriorise large uteri during laparotomic hysterectomy and myomectomy." Wadia Journal of Women and Child Health 1 (July 1, 2022): 29–30. http://dx.doi.org/10.25259/wjwch_2022_10.
Full textAbstract:
Laparotomic hysterectomy commonly referred to as abdominal hysterectomy becomes an especially challenging procedure in large uteri namely size equivalent or larger than 20 weeks size gravid uterus. The biggest challenge in such cases is to exteriorize the uterus from the incision prior to starting with the surgical steps. This case report demonstrates the use of a silastic vacuum cup with a vacuum machine to facilitate the exteriorization of uterus from a regular Pfannenstiel incision.
25
Usuki, Satoshi. "Effects of Tokishakuyakusan, Keishibukuryogan and Unkeito on DNA Polymerase α Activity in PMS-treated Immature Rat Uterus Incubated in Vitro." American Journal of Chinese Medicine 20, no. 03n04 (January 1992): 265–68. http://dx.doi.org/10.1142/s0192415x92000278.
Full textAbstract:
We have recently found that Tokishakuyakusan (TS), Keishibukuryogan (KB) or Unkeito (UT) inhibits in vivo DNA polymerase α activity in the rat uterus stimulated by PMS. In this study, uteri resected 24 h after injection of PMS on day 27 of age were incubated in vitro with 20 μg/ml of extract of TS, KB or UT for 4 h. The DNA polymerase α activity in uteri tended to decrease after the addition of TS, KB or UT with significant difference ( P < 0.05) compared with TS-, KB- and UT-untreated control groups. These results suggest that TS, KB or UT, especially KB, tends to inhibit directly the enzyme activity in rat uterus.
26
Fransisca, Dewi, and Rahmi Novita Yusuf. "HUBUNGAN SENAM NIFAS DENGAN INVOLUSI UTERUS PADA IBU NIFAS." Jurnal Kesehatan Medika Saintika 10, no. 2 (December 9, 2019): 8. http://dx.doi.org/10.30633/jkms.v10i2.332.
Full textAbstract:
Kemenkes RI (2014), penyebab utama kematian ibu di Indonesia adalah perdarahan (30,3%). Setiap 20 orang ibu yang meninggal, 16 orang didominasi oleh ibu nifas. Salah satu penyebab perdarahan adalah atonia uteri. Tujuan penelitian adalah untuk mengetahui Hubungan Senam Nifas Dengan Involusi Uterus Pada Ibu Postpartum. Jenis penelitian adalah quasy experiment dengan pendekatan post test only. Pengumpulan data dilakukan pada bulan Agustus, Populasi adalah seluruh ibu bersalin normal bulan Juni dan Juli tahun 2018 berjumlah 69 orang dengan jumlah sample 20 orang diambil secara quota sampling. Data dikumpulkan dengan mengukur secara langsung Tinggi Fundus Uteri ibu pada hari ke-11 postpartum. Analisa data secara univariat dan bivariat menggunakan Uji Chi Square. Hasil penelitian didapatkan 5 ibu (50%) mengalami proses involusi lambat dari 10 ibu pada kelompok kontrol. Sedangkan 10 ibu pada kelompok intervensi, tidak satupun ibu (0%) mengalami involusi uterus yang lambat dengan p value 0,033. Kesimpulan ada hubungan penerapan senam nifas dengan involusi uterus.
27
Ludke, Ana, Kota Hatta, Alina Yao, and Ren-Ke Li. "Uterus: A Unique Stem Cell Reservoir Able to Support Cardiac Repair via Crosstalk among Uterus, Heart, and Bone Marrow." Cells 11, no. 14 (July 13, 2022): 2182. http://dx.doi.org/10.3390/cells11142182.
Full textAbstract:
Clinical evidence suggests that the prevalence of cardiac disease is lower in premenopausal women compared to postmenopausal women and men. Although multiple factors contribute to this difference, uterine stem cells may be a major factor, as a high abundance of these cells are present in the uterus. Uterine-derived stem cells have been reported in several studies as being able to contribute to cardiac neovascularization after injury. However, our studies uniquely show the presence of an “utero-cardiac axis”, in which uterine stem cells are able to home to cardiac tissue to promote tissue repair. Additionally, we raise the possibility of a triangular relationship among the bone marrow, uterus, and heart. In this review, we discuss the exchange of stem cells across different organs, focusing on the relationship that exists between the heart, uterus, and bone marrow. We present increasing evidence for the existence of an utero-cardiac axis, in which the uterus serves as a reservoir for cardiac reparative stem cells, similar to the bone marrow. These cells, in turn, are able to migrate to the heart in response to injury to promote healing.
28
Hobbie, Kristen R., and Darlene Dixon. "Evaluation of Cystic Endometrial Hyperplasia and the Normal Estrous Cycle in Longitudinal Sections of Uterus from Female Harlan Sprague-Dawley Rats." Toxicologic Pathology 48, no. 5 (June 16, 2020): 616–32. http://dx.doi.org/10.1177/0192623320931768.
Full textAbstract:
The National Toxicology Program (NTP) has recently introduced the practice of examining longitudinal histological sections of the female rodent uterus to improve the identification of non-neoplastic lesions, preneoplastic lesions, and uterine tumors. This practice has created a need for reference material that includes normal histology, spontaneous lesions, and inducible lesions in longitudinal as well as transverse sections of the body of the uterus, uterine horns, cervix and vagina. Using 3 archived NTP reproductive and developmental toxicity studies, the authors reviewed longitudinal and transverse sections of uteri from female Hsd:Sprague Dawley SD® (Hsd:SD) rats for cystic endometrial hyperplasia (CEH). The purposes of this review were to (1) evaluate if existing criteria for CEH in transverse uterine sections could be applied to longitudinal sections to develop diagnostic features of CEH in longitudinal uterine sections of rat uterus and (2) create an atlas of the normal estrous cycle phases in longitudinal sections of young and mature adult Hsd:SD rat uteri. The information provided in this original article should help facilitate the examination of longitudinal sections of the uterus in future commercial and governmental rodent studies.
29
Malahayati, Inke, and Ribka Nova Sartika Sembiring. "Perbandingan Efektifitas Mobilisasi Dini dan Senam Nifas Terhadap Involusi Uterus pada Ibu Postpartum Normal di Bidan Praktek Mandiri (BPM) Kota PematangSiantar." Jurnal Penelitian Kesehatan "SUARA FORIKES" (Journal of Health Research "Forikes Voice") 11, no. 1 (November 12, 2019): 34. http://dx.doi.org/10.33846/sf.v11i1.571.
Full textAbstract:
Failure of the uterus to contract after childbearing is one in all the causes of maternal death. Numerous makes an attempts were created to enhanced the power of the uterus to contract. The aim of the study was to compare the effectiveness of postpartum exercise with early mobilization of uterine involution in normal postpartum. This type of research was a quasi-experimental design with a pretest and posttest design group. This research was implemented in midwives practicing independently. The population of this study was all normal postpartum. The sample of the study was 34 normal postpartum, aged 20-35 years, 2-4 parity, baby born healthy, postpartum haemoglobin ≥ 10.5 gr%, exclusively breastfeeding. Early mobilization was carried out after two hours postpartum and postpartum exercise was carried out for six days. Measurement of the postpartum fundal height was performed on days 1st, 3rd and 7th using a caliper pelvimeter. Consecutive sampling was used in this study. The difference between the two groups was analyzed by unpaired t-test and Mann Whitney U-test. There was a difference in the height of the uterine fundus on the third and seventh postpartum days between the two groups. Postpartum exercise was more effective than early mobilization in accelerating uterine involution. Therefore, it is expected that midwives can facilitate mothers to do postpartum exercise from the first day of postpartum.
Keywords: postpartum exercise; early mobilization; postpartum; involution; uterus
ABSTRAK
Salah satu proses penting pada masa nifas adalah pemulihan organ reproduksi yang ditandai dengan penurunan tinggi fundus uteri dan derajat kontraksi uterus. Secara bertahap, uterus yang berkontraksi dengan baik akan berkurang ukurannya sampai tidak dapat dipalpasi lagi di atas simfisis pubis. Diantara faktor yang berperan dalam kontraksi uterus adalah mobilisasi dini dan senam nifas. Tujuan penelitian adalah untuk membandingkan efektifitas mobilisasi dini dan senam nifas terhadap involusi uterus pada ibu postpartum normal. Jenis penelitian adalah desain kuasi eksperimental dengan kelompok pre dan posttest. Responden penelitian adalah 34 orang ibu postpartum, usia 20-35 tahun di Bidan Praktek Mandiri Kota Pematangsiantar, Juni-September 2016. Teknik pengambilan sampel adalah consecutive sampling sesuai dengan kriteria inklusi. Dilakukan senam nifas pada kelompok intervensi dan mobilisasi dini pada kelompok kontrol. Pengukuran tinggi fundus uteri dilakukan sebelum dan setelah perlakuan pada hari ke-1, -3 dan -7. Analisa data menggunakan uji t-tak berpasanagn dan Mann Whitney menggunakan SPSS versi 20.0. Terdapat perbedaan tinggi fundus uteri hari ke-3 dan ke-7 antara senam nifas dan mobilisasi dini. Senam nifas lebih efektif menurunkan tinggi fundus uteri dibandingkan mobilisasi dini. Bidan diharapkan dapat memfasilitasi ibu melakukan senam nifas sejak hari pertama postpartum.
Kata kunci: senam nifas; mobilisasi dini; postpartum; involusi; uterus
30
Malahayati, Inke, and Ribka Nova Sartika Sembiring. "Perbandingan Efektifitas Mobilisasi Dini dan Senam Nifas Terhadap Involusi Uterus pada Ibu Postpartum Normal di Bidan Praktek Mandiri (BPM) Kota PematangSiantar." Jurnal Penelitian Kesehatan "SUARA FORIKES" (Journal of Health Research "Forikes Voice") 11, no. 1 (November 12, 2019): 34. http://dx.doi.org/10.33846/sf11107.
Full textAbstract:
Failure of the uterus to contract after childbearing is one in all the causes of maternal death. Numerous makes an attempts were created to enhanced the power of the uterus to contract. The aim of the study was to compare the effectiveness of postpartum exercise with early mobilization of uterine involution in normal postpartum. This type of research was a quasi-experimental design with a pretest and posttest design group. This research was implemented in midwives practicing independently. The population of this study was all normal postpartum. The sample of the study was 34 normal postpartum, aged 20-35 years, 2-4 parity, baby born healthy, postpartum haemoglobin ≥ 10.5 gr%, exclusively breastfeeding. Early mobilization was carried out after two hours postpartum and postpartum exercise was carried out for six days. Measurement of the postpartum fundal height was performed on days 1st, 3rd and 7th using a caliper pelvimeter. Consecutive sampling was used in this study. The difference between the two groups was analyzed by unpaired t-test and Mann Whitney U-test. There was a difference in the height of the uterine fundus on the third and seventh postpartum days between the two groups. Postpartum exercise was more effective than early mobilization in accelerating uterine involution. Therefore, it is expected that midwives can facilitate mothers to do postpartum exercise from the first day of postpartum.
Keywords: postpartum exercise; early mobilization; postpartum; involution; uterus
ABSTRAK
Salah satu proses penting pada masa nifas adalah pemulihan organ reproduksi yang ditandai dengan penurunan tinggi fundus uteri dan derajat kontraksi uterus. Secara bertahap, uterus yang berkontraksi dengan baik akan berkurang ukurannya sampai tidak dapat dipalpasi lagi di atas simfisis pubis. Diantara faktor yang berperan dalam kontraksi uterus adalah mobilisasi dini dan senam nifas. Tujuan penelitian adalah untuk membandingkan efektifitas mobilisasi dini dan senam nifas terhadap involusi uterus pada ibu postpartum normal. Jenis penelitian adalah desain kuasi eksperimental dengan kelompok pre dan posttest. Responden penelitian adalah 34 orang ibu postpartum, usia 20-35 tahun di Bidan Praktek Mandiri Kota Pematangsiantar, Juni-September 2016. Teknik pengambilan sampel adalah consecutive sampling sesuai dengan kriteria inklusi. Dilakukan senam nifas pada kelompok intervensi dan mobilisasi dini pada kelompok kontrol. Pengukuran tinggi fundus uteri dilakukan sebelum dan setelah perlakuan pada hari ke-1, -3 dan -7. Analisa data menggunakan uji t-tak berpasanagn dan Mann Whitney menggunakan SPSS versi 20.0. Terdapat perbedaan tinggi fundus uteri hari ke-3 dan ke-7 antara senam nifas dan mobilisasi dini. Senam nifas lebih efektif menurunkan tinggi fundus uteri dibandingkan mobilisasi dini. Bidan diharapkan dapat memfasilitasi ibu melakukan senam nifas sejak hari pertama postpartum.
Kata kunci: senam nifas; mobilisasi dini; postpartum; involusi; uterus
31
Olenin, S. K. "Ten gluttonies I performed in the Gynecological Department of the Tambov Provincial Zemstvo Hospital in the second half of 1895." Journal of obstetrics and women's diseases 11, no. 5 (December 22, 2020): 610. http://dx.doi.org/10.17816/jowd115610.
Full textAbstract:
The indications for these operations were: complete prolapse of the uterus, uterine fibroids, salpyngitis hypertrophica dextra cum retroversione uteri fixata, neoplasm of the bladder and neoplasm of the ovaries.
32
Qiu, Jiaxin, Tong Du, Chen Chen, Qifeng Lyu, Ben W. Mol, Ming Zhao, and Yanping Kuang. "Impact of uterine malformations on pregnancy and neonatal outcomes of IVF/ICSI–frozen embryo transfer." Human Reproduction 37, no. 3 (January 20, 2022): 428–46. http://dx.doi.org/10.1093/humrep/deac003.
Full textAbstract:
Abstract STUDY QUESTION What is the impact of uterine malformations on reproductive and neonatal outcomes of IVF/ICSI–frozen embryo transfer? SUMMARY ANSWER Unification defective uteri are associated with poorer neonatal outcomes including higher preterm delivery rate and lower birthweight, and septate uteri are associated with worse fertility outcomes including higher miscarriage and lower live birth rates (LBRs). WHAT IS KNOWN ALREADY Several studies have investigated the negative effects of uterine malformations on pregnancy outcomes. However, an all-round and definitive conclusion has not been reached yet owing to the relatively low incidence of the disease and the heterogeneity of study populations, especially among women undergoing ART. STUDY DESIGN, SIZE, DURATION This was a retrospective cohort study including 411 women with congenital uterine anomalies and 14 936 women with a normal uterus who underwent first frozen-thawed embryo transfer cycles of IVF/ICSI from July 2008 to August 2019. We compared reproductive outcomes. PARTICIPANTS/MATERIALS, SETTING, METHODS Reproductive outcomes of women with uterine malformations were studied through three propensity score-matched comparisons (patients with bicorporeal uterus, septate uterus and hemi-uterus [bicorporeal, septate and hemi-uterus groups, respectively] along with corresponding control groups without uterine malformations). We also compared pregnancy and neonatal outcomes, and performed subgroup analysis addressing didelphus, bicornuate uteri and septate uteri before and after surgery independently. MAIN RESULTS AND THE ROLE OF CHANCE Compared to the matched control group, women with a bicorporeal uterus had a significantly lower LBR (24.4% versus 34.8%, odds ratio (OR) 0.61 [95% CI: 0.37, 1.00], P = 0.048). The incidence of miscarriage and preterm delivery was higher but not statistically significant (29.0% versus 18.1%, OR 1.85 [95% CI: 0.82, 4.19], P = 0.135; 22.6% versus 9.9%, OR 2.64 [95% CI: 1.07, 6.52], P = 0.063, respectively). In addition, the bicorporeal group had a significantly lower gestational age, higher caesarean rate and lower birthweight than bicorporeal control. Women with a septate uterus had comparable clinical pregnancy rates to controls (43.3% versus 49.9%, OR 0.77 [95% CI: 0.57, 1.04], P = 0.091), increased miscarriage rates (23.5% versus 13.0%, OR 2.05 [95% CI: 1.18, 3.58], P = 0.010) and lower LBRs (29.4% versus 42.2%, OR 0.57 [95% CI: 0.41, 0.79], P = 0.001). In both singleton and twins pregnancies, pregnancy and neonatal outcomes were comparable between women with a septate uterus and control. Women with a hemi-uterus had a tendency for lower clinical pregnancy rate (36.8% versus 42.3%, OR 0.80 [95% CI: 0.52, 1.21], P = 0.287) and LBR (29.8% versus 33.1%, OR 0.86 [95% CI: 0.55, 1.34], P = 0.502), compared to women without malformations. The incidences of miscarriage and preterm delivery, respectively, were 16.7% versus 16.6% (OR 1.01 [95% CI: 0.41, 2.47], P = 0.989), and 9.5% versus 11.4% (OR 0.82 [95% CI: 0.27, 2.51], P = 1) in women with a hemi-uterus as compared to control. LIMITATIONS, REASONS FOR CAUTION This was a single-centre, retrospective study in which neonatal data were extracted from parental questionnaires. The information on uteri septum type and surgery methods was poorly presented, with limited detail. In patients with uterine malformations, the number of babies with birth defects and twin pregnancies was relatively small, limiting the power of the study. WIDER IMPLICATIONS OF THE FINDINGS Compared to patients with a normal uterus, women with uterine malformation have poorer reproductive outcomes. Pregnant women with a uterine anomaly need to be managed as high-risk pregnancies and followed with appropriate obstetric review. STUDY FUNDING/COMPETING INTEREST(S) This work was supported by the National Ministry of Technology (2018YFC1003000), the Elite Team Project of Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine (JY201801), Shanghai Sailing Program (21YF1423200) and the Fundamental Research Program Funding of Ninth People’s Hospital affiliated to Shanghai Jiao Tong University School of Medicine (JYZZ117). B.W.M. is supported by an NHMRC Investigatorgrant (GNT1176437). B.W.M. reports consultancy (with stock options) for ObsEva. B.W.M. has received research funding from Ferring and Merck. The authors declare no other competing interests. TRIAL REGISTRATION NUMBER N/A.
33
Benson, G. V., H. Lim, B. C. Paria, I. Satokata, S. K. Dey, and R. L. Maas. "Mechanisms of reduced fertility in Hoxa-10 mutant mice: uterine homeosis and loss of maternal Hoxa-10 expression." Development 122, no. 9 (September 1, 1996): 2687–96. http://dx.doi.org/10.1242/dev.122.9.2687.
Full textAbstract:
The establishment of a receptive uterine environment is critical for embryonic survival and implantation. One gene that is expressed in the uterus during the peri-implantation period in mice and is required for female fertility is the homeobox gene Hoxa-10. Here we characterize the peri-implantation defects in Hoxa-10 mutant females and investigate functions of Hoxa-10 in the uterine anlage during morphogenesis and in the adult uterus during pregnancy. Examination of pregnancy in Hoxa-10 mutant females has revealed failure of implantation as well as resorption of embryos in the early postimplantation period. Morphologic analysis of the mutant uterus has demonstrated homeotic transformation of the proximal 25% into oviduct. Histology and molecular markers confirm this anterior transformation. Furthermore, in situ hybridization shows that this region coincides with the anterior limit of embryonic Hoxa-10 expression in the urogenital ducts and a parallel transformation is observed in Hoxa-10 mutant males at the junction of the epididymis and ductus deferens. Female fertility could be compromised by either the homeotic transformation or the absence of Hoxa-10 function in the adult during pregnancy. To distinguish between these two potential mechanisms of infertility, wildtype blastocysts were transferred into mutant uteri distal to the transformed region on day 2.5 of pseudopregnancy. This procedure did not rescue the phenotype, suggesting that adult uterine expression of Hoxa-10 is required during pregnancy. Moreover, when implantation was experimentally delayed, homozygous uteri were able to support survival of blastocysts comparable to wild-type controls, indicating that the requirement for Hoxa-10 is intrinsic to implantation. While expression of LIF and HB-EGF appears unaffected in the mutant uteri, a decrease is observed in the intensity and number of blue dye reactions, an indicator of increased vascular permeability in response to implantation. In addition, mutant uteri exhibited decreased decidualization in response to artificial stimuli. These results show that Hoxa-10 is required during morphogenesis for proper patterning of the reproductive tract and in the adult uterus for peri-implantation events.
34
Rijsselaere, T., A. Van Soom, S. Van Cruchten, M. Coryn, K. Görtz, D. Maes, and A. de Kruif. "Sperm distribution in the genital tract of the bitch following artificial insemination in relation to the time of ovulation." Reproduction 128, no. 6 (December 2004): 801–11. http://dx.doi.org/10.1530/rep.1.00273.
Full textAbstract:
In the present study, sperm distribution in the genital tract of the bitch following artificial insemination (AI) in relation to the time of ovulation was investigated by histology, scanning electron microscopy (SEM) and flushing. Ten bitches were inseminated intravaginally with 500 × 106spermatozoa: three dogs before ovulation, four dogs during ovulation and three dogs after ovulation. Ovariohysterectomy was performed 24 h after AI. Half of the genital tract was divided into nine segments (cervix, corpus uteri, caudal, middle and cranial uterine horn (UTH), utero–tubal junction (UTJ), isthmus, ampulla and infundibulum), which were processed for histology and SEM. The contralateral UTH and uterine tube (UT) were flushed, and several sperm characteristics were assessed. Histology revealed that the spermatozoa were mainly located in the uterine glands and at the UTJ, while very few spermatozoa were detected in the UT. Insemination during ovulation resulted in higher percentages of glands with spermatozoa in the different parts of the uterus (P< 0.05). Evaluation by SEM showed higher numbers of spermatozoa in several parts of the uterus for bitches inseminated during ovulation (P< 0.05). The mean number of spermatozoa flushed from the UTH and the UT was low. No significant differences in the evaluated sperm quality parameters were found between the flushings of the UTH and the UT. In conclusion, based on our findings, the uterine glands and the UTJ might act as sperm reservoirs in the bitch and sperm transport in the genital tract is affected by the time of AI in relation to ovulation.
35
Tran, Dinh Nam, Eui-Man Jung, Changhwan Ahn, Jae-Hwan Lee, Yeong-Min Yoo, and Eui-Bae Jeung. "Effects of Bisphenol A and 4-tert-Octylphenol on Embryo Implantation Failure in Mouse." International Journal of Environmental Research and Public Health 15, no. 8 (July 30, 2018): 1614. http://dx.doi.org/10.3390/ijerph15081614.
Full textAbstract:
Miscarriage due to blastocyst implantation failure occurs in up to two-thirds of all human miscarriage cases. Calcium ion has been shown to be involved in many cellular signal transduction pathways as well as in the regulation of cell adhesion, which is necessary for the embryo implantation process. Exposure to endocrine-disrupting chemicals (EDs) during early gestation results in disruption of intrauterine implantation and uterine reception, leading to implantation failure. In this study, ovarian estrogen (E2), bisphenol A (BPA), or 4-tert-octylphenol (OP), with or without ICI 182,780 (ICI) were injected subcutaneously from gestation day 1 to gestation day 3 post-coitus. The expression levels of the calcium transport genes were assessed in maternal uteri and implantation sites. The number of implantation sites was significantly low in the OP group, and implantation sites were absent in the E2, ICI and EDs + ICI groups. There were different calcium transient transport channel expression levels in uterus and implantation site samples. The levels of TRPV5 and TRPV6 gene expression were significantly increased by EDs with/without ICI treatment in utero. Meanwhile, TRPV5 and TRPV6 gene expression were significantly lower in implantation sites samples. NCX1 and PMCA1 mRNA levels were significantly decreased by OP and BPA in the implantation site samples. Compared to vehicle treatment in the uterus, both the MUC1 mRNA and protein levels were markedly high in all but the BPA group. Taken together, these results suggest that both BPA and OP can impair embryo implantation through alteration of calcium transport gene expressions and by affecting uterine receptivity.
36
Lok, J. B., T. Harpaz, and D. H. Knight. "Abnormal patterns of embryogenesis in Dirofilaria immitis treated with ivermectin." Journal of Helminthology 62, no. 3 (September 1988): 175–80. http://dx.doi.org/10.1017/s0022149x00011482.
Full textAbstract:
ABSTRACTThe percentage composition and spatial distribution of embryogenic stages in the uteri of female Dirofilaria immitis were examined at various times after treatment with a microfilaricidal dose of ivermectin and compared to nontreated parasites. Worms sampled 42 days post-treatment (PT) exhibited an increased proportion of stretched microfilariae in the distal portion of the uterus. A decreased proportion of developed embryos was noted in the mid body region of worms sampled 42 days PT, and these forms were completely absent from the proximal area of the uterus. Relative numbers and spatial distribution of other stages remained virtually identical to controls. Radical changes in the composition and spatial distribution of embryogenic forms were noted in the uteri of a single worm sampled 80 days PT. Unlike nontreated parasites and worms sampled 42 days PT, stretched crofilariae constituted the predominant form in the distal uterus of this worm, and these stages were found in decreasing numbers throughout the proximal segments. Also, the intermediate embryogenic stages were either rare or absent.
37
Dong, Y. L., and C. Yallampalli. "Interaction between nitric oxide and prostaglandin E2 pathways in pregnant rat uteri." American Journal of Physiology-Endocrinology and Metabolism 270, no. 3 (March 1, 1996): E471—E476. http://dx.doi.org/10.1152/ajpendo.1996.270.3.e471.
Full textAbstract:
We examined the possible interrelationship between nitric oxide (NO) and cyclooxygenase (COX) products in the uterus during pregnancy and labor. Results indicate that 1) rat uteri during labor, at term, demonstrated a 69% decrease in nitrite production and a 217% increase in prostaglandin E2 (PGE2) production compared with day 18 of pregnancy; 2) interleukin-1 beta (IL-1 beta) induced a pronounced elevation of both nitrites and PGE2 in rat uteri; 3) diethylenetriamine/NO, a donor of NO, induced a significant increase of PGE2 production by the uterus in a dose-dependent manner; 4) NG-nitro-L-arginine methyl ester, an inhibitor of NO synthesis, markedly inhibited IL-1 beta-induced nitrite and PGE2 in rat uteri; this inhibitory action was reversed by coincubation with L-arginine; 5)exogenous PGE2 significantly inhibited IL-1 beta-induced, but not constitutive, nitrite production; and 6) inhibition of endogenous PGE2 by indomethacin substantially increased IL-1 beta-induced nitrite production. Thus the interaction between NO and COX pathways might be important in the regulation of uterine contractility during pregnancy and labor.
38
Akbas, G. Eda, Xiaolan Fei, and Hugh S. Taylor. "Regulation of HOXA10 expression by phytoestrogens." American Journal of Physiology-Endocrinology and Metabolism 292, no. 2 (February 2007): E435—E442. http://dx.doi.org/10.1152/ajpendo.00167.2006.
Full textAbstract:
HOXA10 is necessary for normal development of the Müllerian duct, and continued adult expression in the uterus is necessary for female fertility. HOXA10 expression is altered by diethylstilbestrol, leading to uterine anomalies. Other endocrine disruptors may potentially lead to reproductive anomalies or dysfunction by altering HOXA10 expression. Here we investigated the effect of isoflavones on HOXA10 expression after in utero or adult exposure in the mouse. Genistein, but not diadzein, regulated HOXA10 mRNA and protein expression in the adult mouse uterus. In contrast, in utero genistein or diadzein exposure had no lasting effect on HOXA10 expression in the exposed offspring. Reporter gene expression driven by the HOXA10 estrogen response element was increased in a dose-responsive manner by genistein, but not daidzein. Neither estrogen receptor-α nor estrogen receptor-β binding to the HOXA10 estrogen response element was affected by genistein or daidzein. In utero exposure to isoflavones is unlikely to result in HOXA10-mediated developmental anomalies. Adult genistein exposure alters uterine HOXA10 expression, a potential mechanism by which this agent affects fertility.
39
Rajuddin, Rajuddin, Komalasari Komalasari, and Roziana Roziana. "RUPTUR UTERI SEBAGAI KOMPLIKASI TOLAC PADA PASIEN DENGAN KETUBAN PECAH DINI." AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh 4, no. 2 (November 5, 2018): 111. http://dx.doi.org/10.29103/averrous.v4i2.1042.
Full textAbstract:
Ruptur uteri inkomplit secara klinis signifikan terjadi setelah persalinan caesar sebelumnya dan merujuk pada gangguan lengkap dari semua lapisan uterus, kecuali serosa. Meskipun kejadiaanya sangat jarang, kurang dari 1% dari seluruh uji coba persalinan setelah kelahiran sesar (TOLAC). Komplikasi ini dapat memberikan outcome buruk termasuk komplikasi yang berhubungan dengan perdarahan berat, laserasi kandung kemih, histerektomi, dan morbiditas neonatal yang terkait dengan hipoksia intrauterin. Ruptur uteri inkomplit merupakan salah satu komplikasi TOLAC yang harus segera dikenali agar mendapatkan outcome maternal dan fetal yang lebih baik. Kami melaporkan satu kasus ruptur uteri inkomplit sebagai komplikasi TOLAC pada wanita multipara (G2P1A0) berusia 33 tahun hamil 39-40 minggu dengan ketuban pecah dini. Pasien menolak untuk terminasi kehamilan melalui tindakan seksio sesaria dan diputuskan untuk menjalani TOLAC dengan skor VBAC (Vaginal birth after cesarean delivery) adalah 2 (60%) dan skor Weinstein 4 (58%). Ketika observasi kemajuan persalinan pasien mengalami nyeri perut hebat, kontraksi hipertonik tanpa kelainan denyut jantung janin dan tanpa ring bundlesign. Pasien kemudian menjalani terminasi kehamilan perabdominal. Temuan intraoperatif menunjukkan suatu hematoma di bawah lapisan serosa sebagai akibat dari ruptur uterus inkomplit hingga ke lateral kiri. Setelah menjalani tindakan SC(Sectio Caesarea), ibu dan bayi dalam kondisi yang baik. Ruptur uteri inkomplit terjadi pada sekitar kurang dari 1% dari pasien yang menjalani TOLAC. Ketuban pecah dini yang terkait dengan abruptio plasenta dapat menjadi risiko terjadinya komplikasi ruptur uteri pada TOLAC. Namun, hal ini masih membutuhkan penelitian lanjutan. Sebagian besar ruptur uteri inkomplit asimptomatis atau menunjukkan gejala yang tidak khas. Pengenalan awal kondisi ini dapat menghasilkan outcome maternal dan fetal yang lebih baik.
40
Tiemann, T. T., A. M. Padma, E. Sehic, H. Bäckdahl, M. Oltean, M. J. Song, M. Brännström, and M. Hellström. "Towards uterus tissue engineering: a comparative study of sheep uterus decellularisation." Molecular Human Reproduction 26, no. 3 (January 25, 2020): 167–78. http://dx.doi.org/10.1093/molehr/gaaa009.
Full textAbstract:
Abstract Uterus tissue engineering may dismantle limitations in current uterus transplantation protocols. A uterine biomaterial populated with patient-derived cells could potentially serve as a graft to circumvent complicated surgery of live donors, immunosuppressive medication and rejection episodes. Repeated uterine bioengineering studies on rodents have shown promising results using decellularised scaffolds to restore fertility in a partially impaired uterus and now mandate experiments on larger and more human-like animal models. The aim of the presented studies was therefore to establish adequate protocols for scaffold generation and prepare for future in vivo sheep uterus bioengineering experiments. Three decellularisation protocols were developed using vascular perfusion through the uterine artery of whole sheep uteri obtained from slaughterhouse material. Decellularisation solutions used were based on 0.5% sodium dodecyl sulphate (Protocol 1) or 2% sodium deoxycholate (Protocol 2) or with a sequential perfusion of 2% sodium deoxycholate and 1% Triton X-100 (Protocol 3). The scaffolds were examined by histology, extracellular matrix quantification, evaluation of mechanical properties and the ability to support foetal sheep stem cells after recellularisation. We showed that a sheep uterus can successfully be decellularised while maintaining a high integrity of the extracellular components. Uteri perfused with sodium deoxycholate (Protocol 2) were the most favourable treatment in our study based on quantifications. However, all scaffolds supported stem cells for 2 weeks in vitro and showed no cytotoxicity signs. Cells continued to express markers for proliferation and maintained their undifferentiated phenotype. Hence, this study reports three valuable decellularisation protocols for future in vivo sheep uterus bioengineering experiments.
41
Miller, C., and D. A. Sassoon. "Wnt-7a maintains appropriate uterine patterning during the development of the mouse female reproductive tract." Development 125, no. 16 (August 15, 1998): 3201–11. http://dx.doi.org/10.1242/dev.125.16.3201.
Full textAbstract:
The murine female reproductive tract differentiates along the anteroposterior axis during postnatal development. This process is marked by the emergence of distinct cell types in the oviduct, uterus, cervix and vagina and is dependent upon specific mesenchymal-epithelial interactions as demonstrated by earlier heterografting experiments. Members of the Wnt family of signaling molecules have been recently identified in this system and an early functional role in reproductive tract development has been demonstrated. Mice were generated using ES-mediated homologous recombination for the Wnt-7a gene (Parr, B. A. and McMahon, A. P. (1995) Nature 374, 350–353). Since Wnt-7a is expressed in the female reproductive tract, we examined the developmental consequences of lack of Wnt-7a in the female reproductive tract. We observe that the oviduct lacks a clear demarcation from the anterior uterus, and acquires several cellular and molecular characteristics of the uterine horn. The uterus acquires cellular and molecular characteristics that represent an intermediate state between normal uterus and vagina. Normal vaginas have stratified epithelium and normal uteri have simple columnar epithelium, however, mutant uteri have stratified epithelium. Additionally, Wnt-7a mutant uteri do not form glands. The changes observed in the oviduct and uterus are accompanied by a postnatal loss of hoxa-10 and hoxa-11 expression, revealing that Wnt-7a is not required for early hoxa gene expression, but is required for maintenance of expression. These clustered hox genes have been shown to play a role in anteroposterior patterning in the female reproductive tract. In addition to this global posterior shift in the female reproductive tract, we note that the uterine smooth muscle is disorganized, indicating development along the radial axis is affected. Changes in the boundaries and levels of other Wnt genes are detectable at birth, prior to changes in morphologies. These results suggest that a mechanism whereby Wnt-7a signaling from the epithelium maintains the molecular and morphological boundaries of distinct cellular populations along the anteroposterior and radial axes of the female reproductive tract.
42
Ghiringhelli, M., N. Verdile, T. A. L. Brevini, and F. Gandolfi. "52 Decellularization of goat uterus as a promising 3-dimensional homing matrix of biological scaffold: A pilot study." Reproduction, Fertility and Development 31, no. 1 (2019): 151. http://dx.doi.org/10.1071/rdv31n1ab52.
Full textAbstract:
Female infertility or absence of a functional uterus has a prevalence of 3 to 5% in the general human population. Nowadays most patients diagnosed with absolute uterine factor infertility remain untreatable. Moreover, the world population is aging rapidly, and as people live longer, uterus frailty increases the risk of developing age-related diseases. Whole-organ decellularization and recellularization, a novel technique within the field of regenerative medicine, could eventually provide another solution compared with the reality of gestational surrogacy. Extracellular matrix to enable recellularization has been described using different animal models, where decellularization has been performed of whole uteri. The aim of the present study was to offer a new perspective with a goat uterus as a large whole reproductive organ model. For this purpose, uteri were collected from 6 goats after slaughter and attached to the perfusion circuit. Decellularization was achieved by 2 methods of whole-uterus perfusion, namely with Triton-X100 and dimethyl sulfoxide (group 1; n=3), or with sodium deoxycholate (group 2; n=3), both compared with a control group (n=1). Morphological, immunofluorescence, real-time quantitative PCR analysis, coupled with vascular corrosion cast preparation, were used to assess protocol efficiency. Statistical analysis was carried out to identify significant differences between the 2 groups, using ANOVA and, when required, a post-hoc test (Bonferroni method). Morphological analysis showed different opacity between protocols. In both group 1 and 2, the removal of cells and cellular debris was confirmed with DNA quantification. Immunofluorescence confirmed the presence of the major extracellular matrix components, with collagen type I being the most abundant. Vascular tree network cast of the decellularized organ was successfully perfused in all the uteri. In conclusion, this preliminary study gives a new perspective in whole uterus bioengineering, utilising goats as a biological model to increase the knowledge in veterinary medicine as well as toward the in vitro and in vivo research of regenerative medicine in the field of reproduction. Research was funded by the Carraresi Foundation.
43
Puspitasari, Lina. "Peran Muscle Pumping Exercise pada Ibu Nifas dalam rangka Pemulihan Uterus dan Kestabilan Tekanan Darah." Jurnal Kebidanan Harapan Ibu Pekalongan 6 (August 30, 2019): 225–29. http://dx.doi.org/10.37402/jurbidhip.vol6.iss2.59.
Full textAbstract:
Latar Belakang Penelitian. Masa nifas merupakan masa dari kelahiran plasenta sampai dengan alat kandungan kembali seperti semula sebelum hamil. Sebagian masyarakat beranggapan masa kritis ibu terjadi saat proses persalinan, namun saat masa nifas hal-hal yang tidak diharapkan pun bisa terjadi. Masalah yang dapat membahayakan kesehatan ibu antara lain perdarahan pasca persalinan, atonia uteri, infeksi dalam masa nifas. Oleh sebab itu, perlu adanya tindakan yang efektif dan efisien dalam pencegahan tanda bahaya masa nifas. Tindakan tersebut adalah muscle pumping exercise yang merupakan tindakan untuk mengalirkan darah dari ekstremitas inferior ke arak atrium dextra pada jantung dan pemulihan uterus dalam proses involusi uteri. Tujuan penelitian adalah untuk mengetahui peran muscle pumping exercise pada ibu nifas dalam rangka pemulihan uterus dan kestabilan tekanan darah. Metode penelitian ini merupakan penelitian studi kasus sehingga dalam proses memperoleh data terdiri dari anamnesa, pemeriksaan fisik, pemeriksaan penunjang, latihan penguatan otot abdomen dan dasar panggul, dokumentasi, studi kasus, dan telaah dokumen. Hasil penelitian adalah setelah dilakukan muscle pumping exersice selama 3 kali/ 24 jam didapatkan hasil tekanan darah yang semul 100/60 MmHg berubah menjadi 110/70 MmHg. Kemudian untuk TFU (tinggi Fundus Uteri) yang awalnya teraba setinggi pusat berubah menjadi 2 jari di bawah pusat. Selain itu jumlah darah yang keluar semakin berkurang, ibu selama 24 jam ganti pembalut sebanyak 5 kali dan jarak waktu pergantian pembalut semakin lama. Kesimpulan terdapat pengaruh yang bermakna pada ibu nifas dengan muscle pumping exercise dalam rangka pemulihan uterus dan kestabilan tekanan darah.
44
Baroroh, Ida, and Hilda Prajayanti. "Efektifitas Konsumsi Jus Nanas terhadap Penurunan Tinggi Fundus Uteri pada Ibu Nifas di Kota Pekalongan." Jurnal Kebidanan Harapan Ibu Pekalongan 4 (September 5, 2018): 131–35. http://dx.doi.org/10.37402/jurbidhip.vol4.iss2.8.
Full textAbstract:
ABSTRAK
Masa nifas merupakan masa yang diawali sejak beberapa jam setelah plasenta lahir dan berakhir setelah 6 minggu setelah melahirkan. Perubahan fisiologis yang terjadi pada masa nifas yaitu pengerutan pada uterus yaitu suatu proses kemabalinya uterus ke kondisi semula atau sebelum hamil dengan cara uterus berkontraksi. Proses penurunan tinggi fundus uteri ini dimulai sejak plasenta lahir, apabila proses ini gagal maka disebut sub involusio, sehingga akan memicu terjadi perdarahan pada masa nifas tersebut. Selain pengobatan secara medis, saat ini telah berkembang teknik pengobatan dengan menggunakan tanaman obat. Salah satu tanaman herbal yang dipercaya untuk memperlancar proses penyembuhan atau pemulihan adalah buah nanas. Upaya nonfarmakalogis untuk meningkatkan kontraksi uterus pada ibu post partum adalah dengan mengkonsumsi buah nanas karena kandungan enzim bromelinnya. Bromelin adalah salah satu enzim proteolitik atau protease yang ditemukan pada btanaman nanas (Ananas Comosus (L.Merr)comosus) dan tidak dimiliki oleh buah lainnya. Kandungan bromelin dalam buah nanas paling banyak terdapat di batang dan buah, sedangkan di bagian lain hanya mengandung bromelin dalam jumlah sedikit. Tujuan Penelitian yaitu Mengetahui efektifitas konsumsi jus nanas terhadap penurunan tinggi fundus uteri pada ibu post partum primipara di Kota Pekalongan.Desain Penelian yang digunakan desain penelitian quasi experimental dengan rancangan yang digunakan adalah nonequivalent control group design. Pada penelitian ini menggunakan dua kelompok yaitu kelompok perlakuan dan kelompok kontrol. Kelompok perlakuan diberikan intervensi berupa pemberian jus nanas selama 7 hari yang dicatat pada lembar observasi pemberian jus nanas dan kelompok kontrol diberikan pendidikan kesehatan kebutuhan nutrisis ibu post partum.Hail penelitian diperoleh bahwa Nilai rata-rata penurunan TFU kelompok perlakuan pada kondisi awal mencapai 11,9 cm kemudian mengalami penurunan menjadi 2,5 cm pada hari ketujuh. Rata-rata penurunan TFU kelompok kontrol pada kondisi awal mencapai 14,4 cm kemudian mengalami penurunan menjadi 7,4 cm pada hari ketujuh. Grafik menunjukkan adanya efek dari perlakuan yaitu pemberian jus nanas terhadap penurunan tinggi fundus uteri.
45
Sobestiansky, E. M. "Removal of the uterus through the vagina with the replacement of ligatures with hemostatic tweezers." Journal of obstetrics and women's diseases 11, no. 5 (December 22, 2020): 609. http://dx.doi.org/10.17816/jowd115609.
Full textAbstract:
Having described the methods of removing the uterus through the vagina using tweezers and pointing out the advantages of tweezers over ligatures (simplicity, speed and easier operation technique: the postoperative period is shorter) and their disadvantages (the possibility of bleeding after removing the tweezers, bedsores on the peritoneal lining of the intestines and in the vagina), author proceeds to describe his case of canceris colli uteri, where he produced extirpatio uteri per vaginam in the manner of Pan-Doyen.
46
Tchartchian, Garri, Harald Krentel, Bernd Bojahr, and Rudy L. De Wilde. "LASH in Severely Enlarged Uterine Leiomyoma: Removal of a Uterus of 4065 g." Case Reports in Medicine 2018 (June 25, 2018): 1–4. http://dx.doi.org/10.1155/2018/2078923.
Full textAbstract:
Today, even though minimally invasive approaches have become standard worldwide, large uteri are still mainly removed by means of open abdominal approaches. The present case describes the successful removal of the largest uterus ever reported (4065 g) by means of laparoscopy-assisted supracervical hysterectomy (LASH). We combined LASH with the changeover technique which allows a better access and view. We further explain how this approach allows for the safe minimally invasive removal of uteri of any size.
47
Schoon, H. A., A. Sobiraj, and A. Schönfelder. "Pathologisch-anatomische Veränderungen am torquierten Uterus des Rindes zum Zeitpunkt der operativen Geburtshilfe." Tierärztliche Praxis Ausgabe G: Großtiere / Nutztiere 35, no. 05 (2007): 325–34. http://dx.doi.org/10.1055/s-0037-1621548.
Full textAbstract:
Zusammenfassung Gegenstand und Ziel: Die makroskopischen und mikroskopischen Veränderungen des torquierten Uterus beim Rind zum Zeitpunkt der operativen Geburtshilfe werden erfasst und den Torsionsstadien gegenübergestellt. Material und Methoden: Die makroskopische Befundung erfolgte bei 54 Rindern mit operativer Geburtshilfe infolge Torsio uteri intra partum, die lichtmikroskopischen Untersuchungen wurden an 40 während der Sectio caesarea entnommenen Uteruswandproben durchgeführt. Eine Uteruswandprobe konnte bei der Schlachtung 1,5 Jahre nach erfolgter Sectio caesarea wegen schwerer Torsio uteri entnommen werden. Ergebnisse: Bei den makroskopischen Befunden handelte es sich um Verfärbungen der Uteruswand von rosa-rot über blau-lila bis grau. Die Uteruswand war verdickt und unelastisch. Auf der Oberfläche des Organs waren gestaute Gefäße und Hämatome sichtbar. Selten lag eine Thrombosierung größerer arterieller und venöser Uterusgefäße vor. Das Fruchtwasser erschien unterschiedlich stark blutig verfärbt, die Eihäute wiesen starke Ödeme auf. Die Plazentome waren in einigen Fällen von zirkulären Hämatomen umgeben. Die Ligamenta lata uteri wiesen Hämatome, Ödeme und Rupturen auf. Auch an Mesovarium und Ovarien bestanden Stauungen und Hämatome. Die mikroskopischen Befunde der Uteruswand waren durch Blutungen, Ödeme, Thrombosen, Nekrosen und Entzündung gekennzeichnet. Schlussfolgerung: Alle Strukturen der Gebärmutter und ihrer Adnexe werden durch eine Torsio uteri geschädigt. Klinische Relevanz: Mit zunehmendem Torsionsstadium treten massivere pathologische Veränderungen am Uterus auf. Dabei wird die Prognose hinsichtlich der späteren Fertilität maßgeblich durch Hypoxie und regenerative Entzündungen beeinflusst.
48
Agustian, Wisman, Kurniawan Kurniawan, and Achmad Azhari. "Hubungan Usia dan Paritas dengan Kejadian Mioma Uteri di RSUP Dr.Mohammad Hoesin Palembang Periode Januari 2011–Januari 2012." Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan 4, no. 1 (September 7, 2013): 1. http://dx.doi.org/10.32502/sm.v4i1.1410.
Full textAbstract:
Mioma uteri adalah neoplasma jinak yang berasal dari otot uterus dan jaringan ikat yang menopangnya. Miomauteri juga dikenal dengan istilah fibromioma, leiomoma, ataupun fibroid. Di Indonesia mioma uteri ditemukan2,39 % -11,7 % pada semua penderita ginekologi yang dirawat. Penelitian ini bertujuan untuk mengetahuihubungan usia dan paritas dengan kejadian mioma uteri di RSUP Dr. Mohammad Hoesin Palembang periodeJanuari 2011–Januari 2012. Sampel penelitian ini sebesar 84 sampel dari total 4.440 pasien ginekologi diRSUP Dr. Mohammad Hoesin Palembang periode Januari 2011 – Januari 2012. Hasil penelitian didapatkan 84sampel yang terdiri dari 44 sampel yang di diagnosis mioma uteri dan 40 sampel yang tidak di diagnosis miomauteri, dilakukan analisa bivariat dengan hasil penelitian ini menunjukkan antara usia dengan kejadian miomauteri memiliki hubungan dengan keeratan makna yang lemah (p =0,01; gamma : 0,165), dan untuk statusparitas dengan kejadian mioma uteri juga memikili hubungan namun keeratan maknanya sedang (p = 0,01;gamma: 0,638). Kesimpulan penelitian membuktikan bahwa usia dan paritas dapat mempengaruhi kejadianmioma uteri.
49
Admasari, Yuli. "SENAM NIFAS SEBAGAI ALTERNATIF DALAM MEMPERCEPAT PENURUNAN TINGGI FUNDUS UTERUS IBU PASCA SALIN." Jurnal Kesehatan Tambusai 3, no. 1 (March 25, 2022): 199–204. http://dx.doi.org/10.31004/jkt.v3i1.3972.
Full textAbstract:
Masa nifas berlangsung kurang lebih 6 minggu. Ibu nifas membutuhan latihan tertentu untuk mempercepat proses involusi. Latihan jasmani untuk mengembalikan kondisi kesehatan, melulihkan otot – otot bagian punggung, dasar panggul dan perut pada ibu nifas adalah senam nifas. Di UPTD Puskesmas Tomini selama tiga tahun terakhir ibu nifas tidak melakukan senam nifas karena merasa takut, masih sakit dan capek setelah melahirkan. Tujuan penelitian untuk mengetahui pengaruh senam nifas terhadap tinggi fundus uteri ibu nifas di UPTD Puskesmas Tomini Kabupaten Parigi Moutong. Metode penelitian quasi eksperimental design dengan pendekatan nonequivalent control group design. Populasi seluruh nifas di UPTD Puskesmas Tomini. Sampel berjumlah 30 orang dibagi menjadi 2 kelompok, tehnik sampel purposive sampling. Kelompok kontrol dengan sampel 15 orang diputarkan musik dan ibu bergerak sebisanya sedangkan kelompok intervensi dengan sampel 15 orang diberikan senam nifas 3 hari sekali selama 10 menit dalam waktu 2 minggu. Rata-rata tinggi uterus pada kelompok kontrol 6,33 cm dan kelompok intervensi 5,00 cm. Analisis mengguakan mann whitney dengan hasil nilai Ï= 0,035 berarti senam nifas berpengaruh terhadap penurunan tinggi fundus uteri. Disarankan ibu nifas melakukan senam nifas untuk mempercepat involusi uterus.
Kata Kunci : Tinggi Fundus Uteri, senam nifas
50
Robertson, SA, and RF Seamark. "Granulocyte macrophage colony stimulating factor (GM-CSF) in the murine reproductive tract: stimulation by seminal factors." Reproduction, Fertility and Development 2, no. 4 (1990): 359. http://dx.doi.org/10.1071/rd9900359.
Full textAbstract:
The activity of GM-CSF during early pregnancy in the murine uterine lumen in vivo and in media conditioned by uterine cells in vitro has been assessed. GM-CSF was detected in uterine luminal fluid recovered by lavage on the morning after syngeneic mating (median level 5.7 CFUc U/uterus) and following mating with vasectomized (5.1 U/uterus) or allogeneic males (4.4 U/uterus), with significantly lesser (P less than 0.05) amounts recovered from the uteri of superovulated, mated mice. By contrast, GM-CSF was only detectable (greater than 0.5 U/uterus) in the luminal fluid of three of 22 unmated oestrous mice examined. No activity was detected in secretions from male accessory glands including seminal vesicle, epididymis, prostate and coagulating gland (less than 0.5 U/gland). GM-CSF was found at higher levels in supernatants from cell monolayers prepared by tryptic digest of the uteri of Day 1 mated mice than those from unmated oestrous mice (P less than 0.05). Little GM-CSF was detected in supernatants from ovariectomized mice. An alpha-GM-CSF polyvalent antibody neutralized the FD5/12 bioassay response confirming the identity of the lymphokine. The interleukins IL-2 and IL-3 were not detected in uterine luminal fluid nor in media conditioned by cell monolayers. We postulate that elevated uterine GM-CSF activity after mating is elicited by a non-sperm associated, non-MHC component of the ejaculate and synthesized by a hormone-responsive endometrial cell population. This cytokine may have an embryotrophic role or contribute to priming of the uterus for implantation.