Academic literature on the topic 'Urine – Microbiology'
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Journal articles on the topic "Urine – Microbiology"
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Dumitru, Georgiana, Diana-Gabriela Soare, and Teodoru Soare. "Urine – cytological aspect and microbiology notions." Practica Veterinara.ro 4, no. 33 (2018): 49. http://dx.doi.org/10.26416/pv.33.4.2018.2110.
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Gur’ev, A. S., O. Yu Shalatova, E. V. Rusanova, I. V. Vasilenko, and A. Yu Volkov. "Coherent fluctuation nephelometry in clinical microbiology." Russian Journal of Infection and Immunity 9, no. 2 (July 12, 2019): 385–92. http://dx.doi.org/10.15789/2220-7619-2019-2-385-392.
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In this article data concerning coherent fluctuation nephelometry (CFN) use in clinical microbiology is presented. CFN-analyzer allows to solve two important problems – fast urine screening for bacteriuria within 2-4 hours and antibiotic susceptibility testing within 3-6 hours. Altogether more than 650 urine samples were tested, and the effectivity of CFN-analyzer for preliminary selection of samples for further analysis was shown. Method allows to detect negative samples, reducing the number of urine analyses by 70-80%. Simultaneous analysis of growth curves and concentration of microorganisms shows high sensitivity and specificity (95.2% и 96.9%). Also more than 250 antibiotic susceptibility tests were performed using CFN-analyzer to show its effectiveness for determination of resistant properties of both pure cultures and urine microflora without isolation of bacteria. The agreement with traditional methods was from 84% to 88%. The use of CFN-analyzer with express methods of identification of microorganisms (chromogenic nutrient broths or mass-spectrometry) allows to make full urine analysis within 1-2 days. In the future CFN-analyzer gives an opportunity to screen different human biological liquids, and finds an application for other microbiological tasks, including standardization and speeding-up in sanitary bacteriology.
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Tallman, Gregory B., Miriam R. Elman, Adriane N. Irwin, Brie N. Noble, Peter K. Atkins, YoungYoon Ham, Kallie Waldrip, and Jessina C. McGregor. "Impact of Culturing All Uncomplicated Urinary Tract Infections on the Estimated Prevalence Of Resistance in the Primary Care Setting." Open Forum Infectious Diseases 4, suppl_1 (2017): S349. http://dx.doi.org/10.1093/ofid/ofx163.839.
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Abstract Background Urine cultures to confirm a urinary tract infection (UTI) are not consistently collected in the primary care setting; thus estimates of the prevalence of resistance in uropathogens may be biased. As part of an ongoing study, microbiologic cultures were collected for all patients presenting with uncomplicated UTI at primary care clinics over a six-month period to assess the potential misclassification in frequency of resistance. Methods Data from an electronic health record repository were used to identify clinic encounters for women with a diagnosis code for unspecified UTI or cystitis from six primary care clinics between October 1, 2015 and February 28, 2017 in this cross-sectional study. Prior to August 22, 2016, urine microbiology cultures were collected at the discretion of the provider (usual care period), and from August 22, 2016 to February 28, 2017 urinary microbiology cultures were collected from all patients suspected of having uncomplicated UTI (full culturing period). Urinary microbiology culture and pharmacy data occurring within three days of the encounter were collected. Antibiotic susceptibility data was summarized for isolated Enterobacteriaceae. Frequency of susceptibility to trimethoprim-sulfamethoxazole (TMP-SMX), nitrofurantoin, and fluoroquinolones were compared between usual care vs. the full culturing periods using a chi-square test. Results We identified 131 urine microbiology cultures in the usual care period and 104 in the full culturing period with 61.1% and 55.8%, respectively, being positive cultures. Enterobacteriaceae were isolated from 85.0% of positive cultures in the usual care period and 86.2% in the full culturing period. Between the usual and full culturing periods, antibiotic susceptibility in the Enterobacteriaceae did not differ statistically for TMP-SMX (85.1% vs.. 88.0%; P = 0.65), nitrofurantoin (98.5% vs. 94.0%; P = 0.19), and fluoroquinolones (89.6% vs. 90.0%; P = 0.94). Conclusion Full culturing did not significantly change estimates of the prevalence of antibiotic resistance among Enterobacteriaceae isolated from urine samples. Current urine culturing practices provide adequate susceptibility information to inform empiric prescribing for women with uncomplicated UTIs. Disclosures J. C. McGregor, Merck & Co.: Grant Investigator, Research grant
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Noble, Michael A., and Shirley Nikiforuk. "Variability in Urine Culture Reporting by Canadian Microbiology Laboratories." Canadian Journal of Infectious Diseases 7, no. 4 (1996): 247–49. http://dx.doi.org/10.1155/1996/238498.
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OBJECTIVE: To determine the ability of microbiology laboratories to perform and to report urine colony counts.DESIGN: Clinical Microbiology Proficiency Testing program participants received stabilized simulated urine samples. Laboratories were asked to perform the appropriate test and report results.PARTICIPANTS: One hundred and nine clinical microbiology laboratories in British Columbia, Alberta and Nova Scotia.OUTCOME MEASURES: Consistency of reporting was compared with standards for reporting results as described in theSI Manual in Health Care, 2nd edition.RESULTS: The study demonstrated a wide variation in units used for the reporting of results. Ninety-five (87.2%) laboratories reported quantitative urine results in a variety of unit styles. Of those laboratories providing results with units, 80 (84.2%) used one of 10 variations of SI reporting styles. Fifteen (16.8%) laboratories reported metric units in three different styles. Eleven (10.0%) laboratories reported semiquantitative values without stating units. The remaining three (2.8%) did not respond to the survey.CONCLUSIONS: Many clinical microbiology laboratories have not adopted a consistent form of SI units for reporting quantitative urine culture results. This lack of consistency could potentially lead to interpretation confusion.
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Quiblier, Chantal, Marion Jetter, Mark Rominski, Forouhar Mouttet, Erik C. Böttger, Peter M. Keller, and Michael Hombach. "Performance of Copan WASP for Routine Urine Microbiology." Journal of Clinical Microbiology 54, no. 3 (December 16, 2015): 585–92. http://dx.doi.org/10.1128/jcm.02577-15.
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This study compared a manual workup of urine clinical samples with fully automated WASPLab processing. As a first step, two different inocula (1 and 10 μl) and different streaking patterns were compared using WASP and InoqulA BT instrumentation. Significantly more single colonies were produced with the10-μl inoculum than with the 1-μl inoculum, and automated streaking yielded significantly more single colonies than manual streaking on whole plates (P< 0.001). In a second step, 379 clinical urine samples were evaluated using WASP and the manual workup. Average numbers of detected morphologies, recovered species, and CFUs per milliliter of all 379 urine samples showed excellent agreement between WASPLab and the manual workup. The percentage of urine samples clinically categorized as positive or negative did not differ between the automated and manual workflow, but within the positive samples, automated processing by WASPLab resulted in the detection of more potential pathogens. In summary, the present study demonstrates that (i) the streaking pattern, i.e., primarily the number of zigzags/length of streaking lines, is critical for optimizing the number of single colonies yielded from primary cultures of urine samples; (ii) automated streaking by the WASP instrument is superior to manual streaking regarding the number of single colonies yielded (for 32.2% of the samples); and (iii) automated streaking leads to higher numbers of detected morphologies (for 47.5% of the samples), species (for 17.4% of the samples), and pathogens (for 3.4% of the samples). The results of this study point to an improved quality of microbiological analyses and laboratory reports when using automated sample processing by WASP and WASPLab.
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Ordóñez-Mena, JM, Thomas R. Fanshawe, Dona Foster, Monique Andersson, Sarah Oakley, Nicole Stoesser, A. Sarah Walker, and Gail Hayward. "Frequencies and patterns of microbiology test requests from primary care in Oxfordshire, UK, 2008–2018: a retrospective cohort study of electronic health records to inform point-of-care testing." BMJ Open 11, no. 11 (November 2021): e048527. http://dx.doi.org/10.1136/bmjopen-2020-048527.
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ObjectivesTo inform point-of-care test (POCT) development, we quantified the primary care demand for laboratory microbiology tests by describing their frequencies overall, frequencies of positives, most common organisms identified, temporal trends in testing and patterns of cotesting on the same and subsequent dates.DesignRetrospective cohort study.SettingPrimary care practices in Oxfordshire.Participants393 905 patients (65% female; 49% aged 18–49).Primary and secondary outcome measuresThe frequencies of all microbiology tests requested between 2008 and 2018 were quantified. Patterns of cotesting were investigated with heat maps. All analyses were done overall, by sex and age categories.Results1 596 752 microbiology tests were requested. Urine culture±microscopy was the most common of all tests (n=673 612, 42%), was mainly requested without other tests and was the most common test requested in follow-up within 7 and 14 days. Of all urine cultures, 180 047 (27%) were positive and 172 651 (26%) showed mixed growth, and Escherichia coli was the most prevalent organism (132 277, 73% of positive urine cultures). Antenatal urine cultures and blood tests in pregnancy (hepatitis B, HIV and syphilis) formed a common test combination, consistent with their use in antenatal screening.ConclusionsThe greatest burden of microbiology testing in primary care is attributable to urine culture ± microscopy; genital and routine antenatal urine and blood testing are also significant contributors. Further research should focus on the feasibility and impact of POCTs for these specimen types.
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Khatun, Khadeza, AHM Mostafa Kamal, Kazi Afzalur Rahman, Mohammad Zaid Hossain, Nadia Rabin, SM Shamsuzzaman, and Syed Zakir Hossain. "A Comparative Study of Routine Microscopic Examination of Urine in Microbiology Laboratories at Primary and Secondary Level Before and After Implementation of Standard Operating Procedure (SOP)." Journal of Dhaka Medical College 25, no. 2 (September 13, 2017): 87–93. http://dx.doi.org/10.3329/jdmc.v25i2.33972.
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Context : Laboratory services have become an integral and inseparable component of modern medicine and public health. The use of standard operating procedure (SOP) in laboratory testing is one of the most crucial factor in achieving the quality. This cross sectional study was done to assess the quality of routine microscopic examination of urine of a microbiology laboratory at primary level and one microbiology laboratory at secondary level by evaluating the test results before SOP and re evaluating the test results after implementing SOP to see if there was any improvement in quality of those tests.Material and Methods: A cross sectional, descriptive type of study was conducted in Narsingdi Sador Hospital as secondary level microbiology laboratory and Polash Upzilla Health Complex as primary level microbiology laboratory. The study was performed on clinically suspected patients of urinary tract infection (UTI) attending at the primary and secondary level laboratory for microscopic examination of urine. Clinically suspected cases of UTI who had taken any anti microbial treatment in the past 48 hours were excluded from the study. 60 urine samples were collected from each level before implementing SOP and 30 urine samples were collected from each level and tested after following SOP.Result : In routine microscopic examination of urine at primary and secondary level, before SOP, regarding significant number of Pus cells discrepancy was found in 21.67% cases at primary level and 18.33% cases at secondary level. After implementing SOP, discrepancy in the result was reduced to 10% from 21.67% at primary level and 0% from 18.33% at secondary level. This difference in results was statistically significant (p< 0.05).Conclusion: Implementing SOP and after practicing appropriate and standard techniques for collection and examination of urine at primary and secondary level, discrepancy in the results of routine microscopic examination of urine between investigator and Medical Officer (MOPathology) was reduced and overall quality of tests were improved.J Dhaka Medical College, Vol. 25, No.2, October, 2016, Page 87-93
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Paluck, Felicia, Inbal Kestenbom, Gidon Test, Olivia Ostrow, and Brooke Brimmer. "97 Decreasing invasive urinary tract infection screening in a paediatric emergency department: A quality improvement initiative." Paediatrics & Child Health 26, Supplement_1 (October 1, 2021): e69-e71. http://dx.doi.org/10.1093/pch/pxab061.079.
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Abstract Primary Subject area Emergency Medicine - Paediatric Background Fever is a common presentation among children coming to the Emergency Department (ED) and a urinary tract infection (UTI) often needs to be excluded. Sterile techniques, like catheterization, are invasive, can be traumatizing to children, and are time consuming to complete. A two-step approach has been shown to reduce the catheterization rate in febrile, young children without unintended consequences. Objectives Our aim was to implement a two-step approach for UTI screening in febrile children 6-24 months in order to decrease unnecessary urine catheterizations by 50% without impacting ED length of stay (LOS) or return visits (RVs). Design/Methods After engaging key stakeholders and a nursing champion, we created a process map to understand the current urine collection process in our ED, and areas for targeted improvement. Using the model for improvement, we adopted a 2-step pathway for a suspected UTI in children 6-24 months as our change idea. The pathway involved identifying children who met inclusion criteria for UTI screening, followed by urine bag application and urinalysis (UA) if clinically indicated. Only if the UA was positive, a second urine sample was collected via catheterization, for repeat UA and culture. Through multiple PDSA cycles, our pathway was implemented in the ED along with concurrent staff education. The outcome measure was the rate of ED urine catheterizations. Process measures included the total number of urine cultures sent to microbiology and percent positivity. The balancing measures included ED LOS and RVs. Results Since project initiation in July 2019, the ED catheterization rate decreased from 73% to 53% (Figure 1) and the number of urine cultures sent to Microbiology decreased by 23%. The number of urine cultures sent to Microbiology decreased by 23% with a mild improvement in the positivity rate by 2% (Figure 2). There was no significant change in RVs. There was a slight 10-min increase in ED LOS, most likely confounded by the COVID pandemic. Conclusion Using improvement methodology, we successfully decreased the number of unnecessary catheterizations in children and the number of urine cultures sent to microbiology. Further refinements to our intervention are ongoing and include optimizing urine screening equipment in patient rooms, poster reminders, re-education for providers, and introducing a parent resource explaining the 2-step pathway. This improvement work is also being spread to the paediatric wards and can easily be adopted by other paediatric centres. It has also been adapted by the Choosing Wisely hospital campaign.
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Echavarria, Marcela, Michael Forman, John Ticehurst, J. Stephen Dumler, and Patricia Charache. "PCR Method for Detection of Adenovirus in Urine of Healthy and Human Immunodeficiency Virus-Infected Individuals." Journal of Clinical Microbiology 36, no. 11 (1998): 3323–26. http://dx.doi.org/10.1128/jcm.36.11.3323-3326.1998.
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Adenoviruses (AdV) cause diseases that range from localized, self-limited illnesses to fatal infections in immunocompromised patients. Culture is assumed to be sensitive but requires viable virus and up to 3 weeks for detection, and it can be inhibited by bacterial contamination. A new PCR method amplifying a region of the hexon gene was developed in order to detect AdV in urine more rapidly and with greater sensitivity than obtainable by culture technology. All 18 serotypes tested were detected. Quantitatively, with optimized urine processing, AdV PCR detected 0.2 PFU/ml (serotype 11) and 10 DNA copies/ml (serotype 2). Serially collected urine samples from human immunodeficiency virus (HIV)-infected patients with concurrent cytomegalovirus retinitis were divided into three groups: AdV culture-positive samples, AdV culture-negative or bacterially contaminated samples from patients with a history of AdV culture-positive urines, and AdV culture-negative samples from patients without a history of AdV culture positivity. Urine samples from healthy adults were also tested by culture and PCR to screen for asymptomatic shedding. Amplification was assessed with and without prior DNA purification. AdV was detected by PCR in 90% of culture-positive urines (100% of unclotted samples, e.g., those culture positive after storage for PCR testing), 71% of culture-negative or bacterially contaminated urines from AdV-infected patients, and 28% from AdV culture-negative patients. Healthy volunteers were culture negative for AdV, and 96% were PCR negative. The new AdV PCR method is rapid and sensitive and can detect viral DNA in samples for which culturing is problematic. The role of AdV replication during HIV infection merits further investigation with sensitive tools such as PCR.
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Adams, Jane, Thomas File, Matthew England, Nancy Reynolds, Patricia Wells, and Paula Politis. "Changing the Culture of Ordering Urine Cultures." Infection Control & Hospital Epidemiology 41, S1 (October 2020): s162. http://dx.doi.org/10.1017/ice.2020.685.
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Background: Inappropriate ordering of urine cultures and the resulting unnecessary use of antibiotics can lead to complications of antimicrobial therapy including resistance, adverse effects (eg, disruption of microbiome and C. difficile infection), and increased healthcare costs, as well as the erroneous determination of CAUTI in patients with Foley catheters. A retrospective analysis of patients with CAUTI revealed frequent ordering of urine cultures for conditions and symptoms not supported by current IDSA guidelines. As a result, we created an action plan to reverse the trend of inappropriate urine culture ordering. Methods: Our urine culture reduction campaign was developed with input from the infectious disease service, antibiotic stewardship team (AST), infection prevention, pharmacy, and the microbiology service. The following educational efforts were included: (1) distribution of outpatient pocket cards with communication to providers about appropriate ordering of urine cultures; (2) creation of an evidence-based order set for urinalysis and urine cultures distributed electronically as emails and screensavers on computer stations and in person via didactic sessions with physicians and nursing staff; (3) a practice pointer for staff nurses that included recommended changes to urine culture ordering and encouraged open dialogue with physicians regarding the appropriateness of urine cultures; (4) didactic and personal communications to counter long-standing myths, such as “Urine cultures always for change in mental status”; (5) a peer-review process to evaluate and justify deviations from the testing algorithm.Results: The first and second months after the introduction of the campaign, the microbiology laboratory reported 23% and 37% reductions in urine cultures ordered, respectively. During the same period, a 48% reduction in CAUTIs was reported for the entire health system. Conclusions: Reducing the number of inappropriate urine cultures is achievable with intense communication utilizing a multifaceted approach. With continued educational activities, we expect to sustain and even improve our successful reduction of inappropriate urine culture orders, ultimately improving patient outcomes.Funding: NoneDisclosures: None
Dissertations / Theses on the topic "Urine – Microbiology"
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Perry, Keith Railton. "Detection of antibodies to hepatitis A virus in saliva and urine." Thesis, King's College London (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339125.
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Lever, Mark Stephen. "Characterisation of experimental Q fever infection and the detection of Coxiella burnetii antigens in urine." Thesis, Open University, 1999. http://oro.open.ac.uk/57981/.
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Coxiella burnetii, the aetiological agent of Q fever, causes acute, chronic or asymptomatic disease in humans. Routine clinical diagnosis of acute and chronic Q fever primarily relies on serodiagnosis. Isolation of the organism is rarely attempted, as C. burnetii is known to be amongst the most infectious of bacteria. This thesis aims to define and characterise a relevant experimental model of Q fever and establish whether C. burnetii-specific antigens appear in the urine of experimental animals. It is further intended to characterise any antigens excreted and assess urinary antigen detection as a method for the laboratory diagnosis of Q fever. Experimental C. burnetii infection was established in the guinea pig using Lane strain (a previously uncharacterised British isolate from heart tissue of a patient suffering from Q fever endocarditis). The aerosol route of delivery resulted in a more severe disease compared to delivery by the intraperitoneal route and C burnetii organisms were shown to persist in heart tissues for at least thirteen weeks following aerosol infection. A capture ELISA assay was developed with a detection limit of 80 ng antigen ml*' (equating to approximately 800 organisms ml"). C. burnetii-specific antigens appeared in the urine of animals, infected by aerosol with approximately 1000 organisms and I-10 organisms, at 1 and 10 days post-infection, respectively. During subsequent characterisation of the urinary antigens in severely diseased guinea pigs, viable C. burnetii organisms were detected and a C. burnetii-specific immunoreactive protein with an approximate molecular weight of 62 kDa was demonstrated. Evidence also suggested that LPS was present in the urine. The appearance of antigen in the urine was used as a marker of infection to assess the efficacy of doxycycline and ciprofloxacin in the treatment of experimental Q fever. Preliminary studies supported other data (febrile response, serology and PCR) which suggested that doxycycline was more effective than ciprofloxacin in the treatment of acute experimental Q fever.
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Bertram, Janet. "Effects of cow urine and its constituents on soil microbial populations and nitrous oxide emissions." Diss., Lincoln University, 2009. http://hdl.handle.net/10182/1334.
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New Zealand’s 5.3 million strong dairy herd returns approximately 106 million litres of urine to pasture soils daily. The urea in that urine is rapidly hydrolysed to ammonium (NH₄⁺), which is then nitrified, with denitrification of nitrate (NO₃⁻) ensuing. Nitrous oxide (N₂O), a potent greenhouse gas (GHG), is produced via nitrification and denitrification, which are enzyme-catalysed processes mediated by soil microbes. Thus microbes are linked intrinsically to urine patch chemistry. However, few previous studies have investigated microbial dynamics in urine patches. Therefore the objective of these four experiments was to investigate the effects on soil microbial communities of cow urine deposition. Methods used included phospholipid fatty acid (PLFA) analyses of microbial community structure and microbial stress, dehydrogenase activity (DHA) assays measuring microbial activity, and headspace gas sampling of N₂O, ammonia (NH₃) and carbon dioxide (CO₂) fluxes. Experiment 1, a laboratory study, examined the influence of soil moisture and urinary salt content on the microbial community. Both urine application and high soil moisture increased microbial stress, as evidenced by significant changes in PLFA trans/cis and iso/anteiso ratios. Total PLFAs and DHA showed a short-term (< 1 week) stimulatory effect on microbes after urine application. Mean cumulative N₂O-N fluxes were 2.75% and 0.05% of the nitrogen (N) applied, from the wet (70% WFPS) and dry (35% WFPS) soils, respectively. Experiment 2, a field trial, investigated nutrient dynamics and microbial stress with plants present. Concentrations of the micronutrients, copper, iron and molybdenum, increased up to 20-fold after urine application, while soil phosphorus (P) concentrations decreased from 0.87 mg kg ⁻¹ to 0.48 mg kg⁻¹. Plant P was also lower in urine patches, but total PLFAs were higher, suggesting that microbes had utilised the available nutrients. Microbial stress again resulted from urine application but, in contrast to experiment 1, the fungal biomass recovered after its initial inhibition. Studies published during the course of this thesis reported that hippuric acid (HA) and its hydrolysis product benzoic acid (BA) significantly reduced N₂O-N emissions from synthetic cow urine, thus experiment 3 investigated this effect using real cow urine. Cumulative N₂O-N fluxes were 16.8, 5.9 and 4.7% of N applied for urine (U) alone, U+HA and U+BA, respectively. Since NH₃-N volatilisation remained unchanged, net gaseous N emissions were reduced. Trends in total PLFAs and microbial stress were comparable to experiment 1 results. Experiment 4 studied HA effects at different temperatures and found no inhibition of N₂O-N fluxes from HA-amended urine. However, mean cumulative N₂O-N fluxes were reduced from 7.6% of N applied at 15–20°C to 0.2% at 5–10°C. Total cumulative N emissions (N₂O-N + NH₃-N) were highest at 20°C (17.5% of N applied) and lowest at 10°C (9.8% of N applied). Microbial activity, measured as potential DHA, increased with increasing temperature. This work has clearly shown that the stimulation and inhibition of the soil microbial community by urine application are closely linked to soil chemistry and have significant impacts not only on soil nutrient dynamics but also on N₂O-N emissions and their possible mitigation.
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SANTOS, SOBRINHO Rosemary Alves dos. "Micro-organismos envolvidos em infecções urinárias de mulheres com idade superior a 15 anos atendidas no HC-UFG em 2009 e os perfis de suscetibilidade aos antimicrobianos." Universidade Federal de Goiás, 2011. http://repositorio.bc.ufg.br/tede/handle/tde/1723.
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Previous issue date: 2011-05-06A urinary tract infection (UTI) is a very common disease and can occur at any age. The vast majority of UTIs is caused by enteric bacteria. The study aimed to identify the etiologic agents most frequently, the profile of antibiotic susceptibility and the factors possibly associated to the UTIs recurrents in women older than 15 years, cared for and / or admitted to the Hospital of the University of Goias. From March to November 2009, were invited and accepted to participate in the study 923 women in this age group and they were interviewed using a questionnaire about demographics data and risk factors for recurrent infections. Escherichia coli was the most frequent agent accounting for 67.9% of the total, followed by Enterobacter sp (6.2%), Klebsiella sp (6.2%), Proteus mirabilis (4.5%), Morganella morganii (4.0 %), Acinetobacter baumannii (2.8%) and Staphylococcus aureus (2.2%). %). E. coli showed higher rates of resistance to ampicillin in 46.7% patients with recurrent infection and 50.0% in infections nonrecurring; amoxicillin/clavulanate (32.6% and 35.7%), trimethoprim-sulfamethoxazole (30,0 and 25,0%, respectively) and 100,0% susceptibility to imipenem and nitrofurantoin in both groups. Enterobacter sp showed greater resistance to ampicillin, amoxicillin/clavulanic, norfloxacin and gentamicin (>88.0%) and greater susceptibility to amikacin, cefepime, imipinem and cephalosporins. Klebsiella sp showed high resistance to ampicillin and amoxicillin / clavulanate (> 60.0%) and greater susceptibility to quinolones (> 60.0%), amikacin and imipenem (100.0%) in both groups. There were no statistically significant differences between the risk for recurrent infection or not assessed for menopause, hypertension, hysterectomy, SEL (Systemic Erythematosus Lupus) and smoking. The only risk factor associated to recurrent infection in patients older than 50 years with diabetes. In this study, there was a greater number of E. coli in UTIs, followed by other enterobacteria such as Enterobacter sp and Klebsiella sp. Among all drugs tested, all the micro-organisms, were resistant generally to penicillins, being the most effective quinolones and carbapenems.
A infecção do trato urinário (ITU) é uma patologia muito frequente, podendo ocorrer em qualquer idade. A grande maioria das ITUs é causada por bactérias entéricas. O estudo teve como objetivos identificar os agentes etiológicos mais frequentes, o perfil de suscetibilidade aos antimicrobianos e os fatores possivelmente desencadeantes associados às ITUs recorrentes em mulheres com idade superior a 15 anos, atendidas e/ou internadas no Hospital das Clínicas da Universidade Federal de Goiás. No período de março a novembro de 2009, foram convidadas e aceitaram participar da pesquisa 923 mulheres nesta faixa etária e entrevistadas por meio de questionário sobre dados demográficos e fatores de risco para infecções recorrentes. Escherichia coli foi o agente mais frequente representando 67,9% do total, seguido por Enterobacter sp (6,2%), Klebsiella sp (6,2%), Proteus mirabilis (4,5%), Morganella morganii (4,0%), Acinetobacter baumanii (2,8%) e Staphylococcus aureus (2,2%). E. coli apresentou taxas maiores de resistência à ampicilina 46,7% nas pacientes com infecção recorrente e 50,0% nas com infecções não recorrentes; amoxilina/ácido clavulânico (32,6% e 35,7%), sulfametoxazol-trimetoprima (30,0 e 25,0%) respectivamente e 100,0% de suscetibilidade para nitrofurantoína e imipenem em ambos os grupos. Enterobacter sp demonstrou maior resistência à ampicilina, amoxicilina/ácido clavulânico, norfloxacina e gentamicina (>88,0%) e maior suscetibilidade à amicacina, cefepime, imipinem e cefalosporinas. Klebsiella sp demonstrou alta resistência para ampicilina e amoxicilina/ácido clavulânico (>60,0%) e maior suscetibilidade às quinolonas (>60,0%), amicacina e imipenem (100,0%) nos dois grupos estudados. Não foram detectadas diferenças estatisticamente significantes entre o risco para infecção recorrente ou não avaliado para menopausa, hipertensão, histerectomia, LES (Lúpus Eritematoso Sistêmico) e tabagismo. O único fator de risco associado à infecção recorrente foi diabetes em pacientes com mais de 50 anos. Neste estudo, verificou-se um maior número de E. coli nas ITUs e incidência bem menor de outras enterobactérias como Enterobacter sp e Klebsiella sp. Entre os antimicrobianos testados todos os micro-organismos foram resistentes, de um modo geral, às penicilinas sendo mais efetivos as quinolonas e carbapenemas.
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Reis, Maria Inês Santos dos. "Relatório de Estágio." Master's thesis, 2019. http://hdl.handle.net/10316/88184.
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Relatório de Estágio do Mestrado em Análises Clínicas apresentado à Faculdade de FarmáciaA elaboração do presente relatório de estágio tem como objetivo a descrição das atividades realizadas no âmbito do estágio curricular do Mestrado em Análises Clínicas da Faculdade de Farmácia da Universidade de Coimbra, efetuado no laboratório de análises clínicas Coimbralab. O Coimbralab iniciou a sua atividade em 1984, sendo atualmente constituído por um laboratório central na zona do Vale das Flores, em Coimbra, e diversos postos de colheitas, tendo como objetivo a realização de análises clínicas e integrando vários setores funcionais, sendo estes: hematologia, coagulação, microbiologia, bioquímica, urianálise, coprologia, imunologia/imunoquímica, serologia, toxicologia, monitorização de drogas e endocrinologia. Ao longo dos dois anos do Mestrado em Análises Clínicas foram-nos transmitidos conhecimentos teóricos que, com alguma formação prática complementar, nos permitem desempenhar um papel ativo, como profissionais de saúde, no laboratório de análises clínicas, como tivemos oportunidade de experienciar durante o estágio curricular. Os laboratórios de análises clínicas têm um papel fundamental na manutenção da qualidade de vida das populações, sendo os resultados analíticos obtidos essenciais não só para auxiliar o clínico a efetuar diagnósticos, mas também para alertar para a possibilidade de existência de determinadas patologias e acompanhar/monitorizar o tratamento das mesmas. Desta forma, o laboratório deve garantir a qualidade de todos os seus resultados. Estes laboratórios têm vindo a sofrer alterações no seu funcionamento, utilizando-se cada vez mais equipamentos automáticos em detrimento das técnicas manuais, o que permite fornecer os resultados mais rapidamente e reduzir o número de erros pelo operador. Assim, este relatório inclui uma abordagem geral do local de estágio, uma descrição dos procedimentos pré-analíticos, analíticos e pós-analíticos, assim como do controlo de qualidade de cada uma das áreas. Os procedimentos analíticos são os mais detalhados, focando-se principalmente nas áreas de Imunologia e Microbiologia.
The elaboration of the following report aims to describe the developed curricular internship activities of the Clinical Analysis MSc degree of the Faculty of Pharmacy of Coimbra University, that took place at the Coimbralab laboratory. Coimbralab began its activities in 1984, which is now constituted by a central laboratory in Vale das Flores, in Coimbra, and several collection stations. Its aim is to carry out clinical analysis, combining various functional sectors, such as: hematology, coagulation, microbiology, biochemistry, urinalysis, coprology, immunology/immunochemistry, serology, toxicology, drug monitoring and endocrinology. The theoretical knowledge acquired throughout the two years of the MSc degree in Clinical Analysis, complemented with some further practical training, enables us to perform an active role as health professionals in the clinical analysis laboratory, as we had the opportunity to experience during the curricular internship. Clinical analysis laboratories perform a fundamental role in maintaining the population's quality of life, and the analytical results obtained are essential not only to help the clinician make diagnosis, but also to alert for the possibility of certain pathologies and its treatment's monitoring. From this, the laboratory must assure the quality of all its results. These laboratories have been suffering changes in its operating mode by increasing the use of automated equipment over manual techniques, which allows to deliver results faster and reduce the number of errors by the operator. So, this report includes a general approach of the internship, a description of the pre-analytical, analytical and post-analytical procedures, as well as the quality control of each area. The analytical procedures are the most detailed, focusing mainly on the Immunology and Microbiology areas.
Books on the topic "Urine – Microbiology"
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Modern urine chemistry: Application of urine chemistry and microscopic examination in health and disease. Elkhart, Ind: Miles Inc., Diagnostics Division, 1991.
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United States. National Aeronautics and Space Administration., ed. Microbiological test results using three urine pretreatment regimes with 316L stainless steel. [Washington, DC: National Aeronautics and Space Administration, 1993.
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Saunders. Saunders Clinical Skills for Medical Assistants: Disk Six: Collecting and Testing Urine and Microbiology Specimens. Saunders, 2006.
Find full textBook chapters on the topic "Urine – Microbiology"
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Jain, Aakanchha, Richa Jain, and Sourabh Jain. "Qualitative Analysis of Urine for Abnormal Constituents." In Basic Techniques in Biochemistry, Microbiology and Molecular Biology, 191–200. New York, NY: Springer US, 2020. http://dx.doi.org/10.1007/978-1-4939-9861-6_45.
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"Urine Cultures." In Clinical Microbiology Procedures Handbook, 3.12.1–3.12.33. Washington, DC, USA: ASM Press, 2016. http://dx.doi.org/10.1128/9781555818814.ch3.12.
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"Urine Cultures." In Clinical Microbiology Procedures Handbook, 3rd Edition, 410–40. American Society of Microbiology, 2010. http://dx.doi.org/10.1128/9781555817435.ch3.12.
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Gillespie, S. H. "Examination of urine and pus." In Medical Microbiology Illustrated, 211–21. Elsevier, 1994. http://dx.doi.org/10.1016/b978-0-7506-0187-0.50023-7.
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"The urine specimen." In Medical Microbiology Testing in Primary Care, 45–66. CRC Press, 2012. http://dx.doi.org/10.1201/b15133-4.
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Ahmed, Armin. "Blood and Urine Sampling for Microbiology." In Manual of ICU Procedures, 667. Jaypee Brothers Medical Publishers (P) Ltd., 2016. http://dx.doi.org/10.5005/jp/books/12634_60.
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"Body Fluid Cultures (Excluding Blood, Cerebrospinal Fluid, and Urine)." In Clinical Microbiology Procedures Handbook, 3.5.1–3.5.9. Washington, DC, USA: ASM Press, 2016. http://dx.doi.org/10.1128/9781555818814.ch3.5.
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"Body Fluid Cultures (Excluding Blood, Cerebrospinal Fluid, and Urine)." In Clinical Microbiology Procedures Handbook, 3rd Edition, 183–91. American Society of Microbiology, 2010. http://dx.doi.org/10.1128/9781555817435.ch3.5.
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Wong, T. H. Nicholas. "Case 24." In Oxford Case Histories in Infectious Diseases and Microbiology, edited by Maheshi Ramasamy, 158–62. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198846482.003.0024.
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BK virus are human polyomaviruses associated with BK virus-associated nephropathy (BKVAN) in post-transplant recipients on immunosuppression. Primary infection is usually asymptomatic, and the virus will remain in a latent phase. Reactivation usually occurs due to a number of risk factors, namely target organ damage and a reduction in the host immune function. BK virus can also cause haemorrhagic cystitis in haemopoietic stem cell transplant recipients. Diagnosis of BKVAN can range from visualization of decoy cells in urine microscopy (low sensitivity and high specificity) to serum and urine polymerase chain reaction (PCR) (high sensitivity and high specificity). Screening for BKVAN is generally recommended post transplantation. There is currently no specific antiviral therapy and the mainstay of treatment involves reduction in immunosuppressive agents.
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Shen, Cangliang, and Yifan Zhang. "Clinical lab practice - urine sample bacteria isolation and numeration." In Introductory Microbiology Lab Skills and Techniques in Food Science, 111–18. Elsevier, 2022. http://dx.doi.org/10.1016/b978-0-12-821678-1.00015-0.
Full textConference papers on the topic "Urine – Microbiology"
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Costa, Graciele Pereira, and DANIELLE PEREIRA COSTA SILVA. "PRINCIPAIS MICROORGANISMOS ENCONTRADOS EM PACIENTES COM INFECÇÕES DO TRATO URINÁRIO (ITU) E MÉTODOS DE DIAGNÓSTICOS UTILIZADOS." In II Congresso Nacional de Microbiologia Clínica On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conamic/03.
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Introdução: A infecção do trato urinário (ITU) é considerada um dos problemas clínicos mais comuns e consiste na presença assintomática de bactérias na urina até infecção renal grave. O diagnóstico é considerado muitas vezes difícil clinicamente, sendo necessário a realização de exames de urinálise e cultura urinária ou outros exames para descobrir a origem da infecção. Objetivo: Objetivou-se com a realização deste estudo conhecer os microorganismos mais prevalentes nas infecções urinárias, e delinear os métodos diagnósticos. Material e métodos: O presente estudo trata-se de uma revisão de literatura. As bases de dados utilizadas foram o PubMed, Scientific Eletronic Library Online (SciELO), Medline e refere-se às publicações dos últimos seis anos (2015 a 2021). Resultados: O diagnóstico da infecção do trato urinário é realizado pelo exame clínico e por exames laboratoriais de triagem como o sumário de urina e o diagnóstico confirmatório através do exame de cultura de urina, também conhecida como urocultura, na qual haverá o crescimento e quantificação do microorganismo causador. Uma dificuldade apresentada por este exame é a demora dos resultados, que possuem duração de mais de 24horas. Também se realiza o antibiograma, chamado de Teste de Sensibilidade a Antimicrobianos – TSA, que é essencial para monitorar e conduzir um tratamento adequado e eficiente. Entre os principais microorganismos responsáveis pela ITU, a Escherichia coli é considerada uma das bactérias mais prevalentes, seguida pela Klebsiella pneumoniae e Proteus mirabilis. Conclusão: É grande a quantidade de pacientes com infecção do trato urinário que são tratados com utilização de antibióticos de forma indevida, apresentando resistência bacteriana, sendo assim é de suma importância um diagnóstico eficaz. O diagnóstico da ITU enfrenta um grande desafio e há necessidade de novos exames para utilização em rotinas, principalmente do serviço único de saúde. Também é de suma importância a conscientização dos profissionais para realização de exames conclusivos antes de se realizar a intervenção terapêutica.
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Lindesay Neto, Edgard, and Lucieny De Faria Souza. "INFECÇÃO DO TRATO URINÁRIO (ITU) POR ESCHERICHIA COLI." In I Congresso Nacional de Microbiologia Clínica On-Line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1209.
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Introdução: A ITU é caracterizada pela multiplicação bacteriana com invasão dos tecidos em qualquer parte do aparelho urinário, sendo mais frequente em crianças e adultos do sexo feminino, podendo ser sintomáticas ou assintomáticas, identificadas pela existência de bactéria na urina em concentração superior a 100.000 UFC/ml. As bactérias são as maiores responsável pelas ITUs, onde se destacam os cocos gram-negativos isolados em 93,10%, dentre elas a família das Enterobactérias possui maior prevalência e a pertencente deste grupo com maior destaque é a E. Coli, sendo responsável por pelo menos 70% de todas as ITUs. Objetivo: Descrever a importância das ITU por E. coli e seus impactos na saúde pública. Material e métodos: Trata-se de uma revisão bibliográfica narrativa. Resultados: Nos Estados Unidos as ITUs são responsáveis por 8,3 milhões de atendimentos médicos por ano, estima-se 250 milhões de casos por ano no mundo e os gastos aproximados ficam em torno de 6 bilhões de dólares em despesas diretas de cuidados em saúde. Estudos europeus mostram que as ITUs só ficam atrás das infecções respiratórias. A ITU constitui um foco importante para sepse e é considerada a terceira ocorrência mais comum durante a gestação. A doença é mais frequente nas mulheres devido a proximidade com o anus, porém acomete homens com doença na próstata e uso de cateter vesical. A resistência bacteriana das E. coli uropatogênica é uma grave ameaça a saúde mundial, sendo descrita pela OMS. Conclusão: A ITU é uma doença de alta prevalência, incidência e impacto na saúde mundial, tornando estudos a respeito da patologia necessários.
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Fávaro, Larissa Dos Santos, Suelen Balero De Paula-Petroli, Renato Eiki Radoski, Floristher Elaine Carrara-Marroni, and Emerson José Venâncio. "MONITORAMENTO DE ISOLADOS DE PSEUDOMONAS SPP. RESISTENTES ÀS POLIMIXINAS RECUPERADOS NO HOSPITAL UNIVERSITÁRIO DE LONDRINA." In I Congresso Nacional de Microbiologia Clínica On-Line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1167.
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Introdução: Pseudomonas spp. é um importante patógeno responsável por infecções hospitalares de difícil tratamento. O aumento no número de isolados resistentes aos carbapenêmicos, antimicrobianos utilizados no tratamento de infecções causadas por isolados multirresistentes (MR) aos antimicrobianos, tem levado a retomada do uso das polimixinas como último recurso terapêutico. O monitoramento das taxas de resistência aos antimicrobianos norteia as terapias empíricas, possibilitando o aprimoramento do tratamento, aumentando a chance de sucesso terapêutico e diminuindo o tempo de permanência do paciente nos hospitais. Objetivo: Determinar o perfil dos isolados clínicos de Pseudomonas spp. resistentes as polimixinas recuperados no Hospital Universitário (HU) de Londrina no período de janeiro de 2004 a dezembro de 2020. Métodos: Foram analisados dados referentes às culturas positivas para Pseudomonas spp. resistentes as polimixinas quanto ao sexo do paciente, tipo de amostra biológica, setor de internação e perfil de sensibilidade aos antimicrobianos. Apenas uma amostra por paciente foi incluída no estudo e foram utilizados os dados somente do primeiro isolamento. Resultados: Um total de 66 isolados foram incluídos no estudo. A maioria dos isolados (74,2%) foram recuperados de pacientes do sexo masculino internados nas Unidades de Tratamento Intensivo (43,9%), Enfermaria Masculina (16,7%) e Unidades de Tratamento de Queimados (9,1%). Urina (51,5%), secreções do trato respiratório (19,7%) e tecido (7,6%) foram às amostras clínicas com maior frequência de isolamento destes microrganismos. Do total de isolados, 34,8% foram classificados como MR e 59,1% como extensivamente resistente (ER) aos antimicrobianos. Taxas elevadas de resistência foram verificadas para os carbapenêmicos (84,8% - Imipenem/65,2% - Meropenem), fluoroquinolonas (81,8% - Ciprofloxacin), cefalosporinas (80,3% - Ceftazidima/72,7% - Cefepime), aminoglicosídeos (83,3% - Gentamicina/81,8% - Amicacina) e polimixinas (43,9% - Polimixina B/68,2% - Colistina). Discussão: As altas taxas de resistência observadas demonstram as limitações terapêuticas em infecções causadas por Pseudomonas spp. no HU, enfatizando a importância do monitoramento, adequação de medidas efetivas de controle de infecção, bem como a necessidade de programas stewardship para o uso racional dos antimicrobianos.
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Veríssimo, Graciete Soares Libório, Ivanize Barbosa De Souza Almeida, and Paula Carvalhal Lage Von Buettner Ristow. "O PAPEL DA FORMAÇÃO DE BIOFILME EM LEPTOSPIRA: PROTEÇÃO DA AGRESSÃO DO MEIO AMBIENTE E INVASÃO E EVASÃO DO HOSPEDEIRO." In I Congresso Nacional de Microbiologia Clínica On-Line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/1193.
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Introdução: Leptospiras são bactérias Gram-negativas, capazes de sobreviver no solo e na água por longos períodos. O gênero Leptospira é classificado em espécies saprofíticas e patogênicas. Leptospira patogênica causam leptospirose, zoonose com incidência global com mais de um milhão de casos e 58.900 mortes anual em todo o mundo. A leptospirose é transmitida através de solo ou água contaminada, pela urina do Rattus norvegicus, principal hospedeiro, que eliminam leptospiras viáveis no ambiente. Leptospira patogênicas podem infectar qualquer mamífero, inclusive o ser humano. In vitro e em ambientes naturais, Leptospira formam biofilmes, o que pode estar associado a sobrevivência da bactéria no ambiente por longos períodos. Biofilmes são comunidades de microrganismos aderidos a superfície, envolvidos em uma matriz extracelular, os quais protegem os microrganismos contra radiação, dessecação, antibioticoterapia e defesas do sistema imune. Objetivo: Neste estudo buscamos analisar o papel do biofilme na sobrevivência de Leptospira no meio ambiente e como este biofilme pode contribuir para invasão e evasão no hospedeiro. Material e métodos: Consistiu-se em uma revisão de literatura, a partir de uma abordagem qualitativa, na base de dados Pubmed, utilizando como termo de busca booleano (biofilm[Title/Abstract]) AND (leptospira[Title/Abstract]). Foram encontrados 15 artigos, compreendendo o período de 2003 a 2020. Resultados: A formação de biofilmes desempenham papeis importante em sua capacidade de sobrevivência em diversos habitats ambientais, principalmente para as bactérias patogênicas, que permanecem viáveis até infectar novos hospedeiros. Etapas iniciais na formação de biofilme em Leptospira, fornecem informações detalhadas sobre estratégias usadas para criar biofilmes resilientes, e assim, se proteger contra estresses extracelulares. Também identificamos que a via c-di-GMP é funcional, além de exercer um papel formação de biofilme desta bactéria. Já foi demonstrado na literatura que Leptspira compõem biofilme mistos, e que quando usado a concentração subinibitória de antibióticos, estimula a produção de biofilme e as protegem contra antibioticoterapia. Conclusão: Por conseguinte, sugere-se que biofilmes estejam relacionados à patogênese da leptospirose. Desde a sua sobrevivência no meio ambiente, assim como na evasão no hospedeiro. Aspectos estruturais do biofilme e da composição da matriz extracelular ainda são pouco conhecidos. E necessitam ser mais explorados.
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Andrade, Janyara Anny Azevedo de, JACYARA ABEACY AZEVEDO DE ANDRADE, FILIPE DE ALMEIDA AGRA OMENA, JÉSSIKA NATANA VALERIANO ANDRADE DE OLIVEIRA, and RILVA MARIA DA SILVA. "ANÁLISE DA EFICÁCIA DA PUNICA GRANATUM LINNAEUS CONTRA ESCHERICHIA COLI." In II Congresso Nacional de Microbiologia Clínica On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conamic/29.
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Introdução: A Punica granatum Linnaeus (romã), dentre as mais variadas finalidades do emprego de preparos derivados da mesma, tem como destaque o frequente uso no combate a Infecção do Trato Urinário (ITU). A ITU se determina pela existência de microrganismos na urina, as infecções bacterianas são mais frequentes, acometendo uma significante parcela da população, principalmente, feminina. Objetivos: Realizar uma revisão integrativa da literatura sobre a ação da Punica granatum Linnaeus (romã) no tratamento da infecção urinária feminina causada pela bactéria Escherichia coli. Material e métodos: A pergunta norteadora definida foi: “De que forma a Punica granatum Linnaeus pode agir no tratamento da infecção urinária feminina contra a Escherichia coli?”. Foi realizada uma busca da literatura através das principais bases de dados eletrônicas: ScienceDirect; LILACS, uma biblioteca eletrônica: SciELO, usando os termos (MeSH): “Urinary Infection e Pomegranate”. Os artigos foram avaliados quanto aos critérios de inclusão e exclusão pré-estabelecidos. Resultados: A partir dessa estratégia de busca, 6 (seis) artigos científicos foram selecionados. As infecções do trato urinário constituem-se pela resposta do organismo a uma invasão bacteriana, e estima-se que 95% dos casos são causadas por bactérias Gram-negativas, sendo a Escherichia coli a mais comum. Diante disso, 60% da população feminina têm ao menos um episódio de ITU ao longo da vida. Assim, o Brasil possui uma variedade muito extensa de fitoterápicos que são comumente usados para extinguir diversos problemas de saúde de origem bacteriana e parasitária, infecções e viroses em geral. É imprescindível, pois, que a Punica granatum Linnaeus é uma planta com várias ações terapêuticas, principalmente com atividade antimicrobiana e potencialidade para combater doenças a partir dos extratos utilizados sobre as linhagens de Escherichia coli, ressaltando caso as pacientes apresentem resistência bacteriana às medicações usuais. Conclusão: Com os dados analisados, a revisão respondeu à pergunta norteadora, mas, infelizmente, a literatura escasseia de pesquisas sobre o extrato da Punica granatum Linnaeus, a fim de obter um método terapêutico alternativo, seguro, menos dispendiosa e que também atue reduzindo a ITU, visto que, estudos prévios revelaram que fitocompostos da casca do fruto induzem o aumento da liberação de IL-10, promovendo, assim, uma resposta anti-inflamatória.
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MAIA, DIEGO OLIVEIRA, JÚLIA DE HOLLANDA CELESTINO, LORENA AGRA RAMOS, EMANUEL VICTOR DA SILVA LIMA, and TATIANA PASCHOALETTE RODRIGUES BACHUR. "FEBRE DE LASSA: TERIA ESSA DOENÇA POTENCIAL PANDÊMICO?" In II Congresso Nacional de Microbiologia Clínica On-line. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/ii-conamic/16.
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Introdução: A febre de Lassa (FL) é uma infecção hemorrágica causada por um Mammarenavirus – o LASV – vírus de RNA de fita simples da família Arenaviridae. O principal reservatório do LASV é o camundongo Mastomys natalensis, comum no continente africano. A maioria dos casos são assintomáticos, porém a FL pode manifestar-se clinicamente através de febre, mal-estar, tosse, dor no peito, cólicas abdominais, vômitos, diarreia e dor de garganta. Casos graves evoluem com manifestações hemorrágicas e elevada taxa de mortalidade. A transmissão da infecção pode ocorrer por meio do contato com urina, fezes ou saliva do roedor ou mediante contato direto com fluidos corporais de indivíduos infectados ou superfícies contaminadas. Objetivo: Realizar uma levantamento bibliográfico acerca da epidemiologia da febre de Lassa e sua possível capacidade de disseminação global. Métodos: Foi realizada uma pesquisa bibliográfica nas bases de dados MEDLINE e EMBASE, por meio dos descritores “lassa fever” e “epidemiology”, combinados pelo operador booleano AND. A partir de critérios de inclusão e exclusão pré-estabelecidos, foram selecionados seis artigos para compor este trabalho. Resultados: A FL se apresenta como uma doença endêmica na África Ocidental, com comportamento sazonal, tendo incremento de casos no início e no final do período chuvoso. O primeiro caso de FL foi relatado na Nigéria na década de 1960 causando, desde então, vários surtos nesse país e em países adjacentes, com taxas de mortalidade de até 50%. Contudo, a infecção já foi descrita fora da área endêmica, tendo sido relatados pelo menos 35 casos exportados para países como Estados Unidos, Reino Unido, Alemanha e Japão, no período de 1969 a 2020, o que tem sido associado às atividades humanas de comércio e migração. Até o momento, apenas um caso de transmissão autóctone em área indene foi relatado em consequência de casos importados da África Ocidental. Conclusão: A febre de Lassa apresenta-se como uma doença endêmica no continente africano, porém com capacidade disseminativa para outras regiões do globo, o que torna necessário que haja maior vigilância epidemiológica para reconhecimento dos casos, especialmente os assintomáticos, que representam a maioria dos acometidos, visto que a doença pode ser transmitida entre indivíduos infectados.