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1

Rabin, Eliane Goldberg. "Função sexual de mulheres portadoras de incontinência urinária e submetidas a tratamento cirúrgico." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2012. http://hdl.handle.net/10183/53150.

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Atualmente a International Continence Society (ICS) define IU como qualquer perda involuntária de urina e é considerada um problema social e/ou de higiene valorizando a queixa das pacientes. A prevalência da IU em mulheres adultas tem sido estimada entre 10 e 40 %, e pode piorar com o envelhecimento, paridade e obesidade. Uma doença de baixa morbidade é responsável por até 30% do movimento cirúrgico de um ambulatório de ginecologia; por isso, a indicação precisa do tratamento é fundamental. O tratamento cirúrgico deve ser oferecido para incontinência moderada a severa ou na falha do tratamento clínico. Vários estudos têm mostrado que a IU está associada com a disfunção sexual, relatados por até dois terços das mulheres, no mundo, com sintomas como dispareunia, ressecamento vaginal e dificuldade para atingir o orgasmo, entre outros. Objetivo: O objetivo deste estudo foi comparar a função sexual de mulheres com incontinência urinária, antes e depois do tratamento cirúrgico. Método: Este estudo foi realizado no Hospital de Clínicas de Porto Alegre e na Irmandade Santa Casa de Misericórdia de Porto Alegre entre agosto de 2009 e novembro de 2011. Tratase de um ensaio clinico controlado não randomizado que avaliou a função sexual de mulheres com incontinência urinária utilizando o instrumento Female Sexual Function Index (FSFI) e submetidas a tratamento cirúrgico (Burch ou Sling). A amostra total se constituiu de 38 mulheres que preencheram o questionário FSFI no pré-operatório e seis meses após Intervenção: Cirurgia de Burch ou Sling Instrumentos: Questionário FSFI, variáveis clínicas e demográficas. Resultados: Trinta e oito mulheres foram incluídas no estudo e assinaram o Termo de Consentimento Livre e Esclarecido. A média de idade das mulheres foi 48 anos, todas sexualmente ativas. Oito mulheres fizeram o procedimento cirúrgico tipo Burch e trinta mulheres tipo Sling. No grupo Sling as mulheres eram mais velhas do que as do grupo Burch tinham maior tempo de vida em comum com seus parceiros (24,3 + 11,9) e um IMC de sobrepeso/obesidade (28,4 + 3,3). Não houve diferença estatisticamente significativa no préoperatório nos domínios do FSFI, porém no pós-operatório o escore geral indicou uma melhora da função sexual. Conclusões: Os domínios desejo e excitação melhoraram significativamente após a cirurgia para toda a amostra estudada. Aquelas que apresentaram cistocele tiveram uma melhora da função sexual no domínio dor e desconforto.
Aims: The Female Sexual Function Index (FSFI) is a scale to assess sexual dysfunction in women. This study compared sexual function of women with urinary incontinence before and after surgical treatment. Methods: This nonrandomized clinical controlled trial was conducted in the Hospital de Clínicas de Porto Alegre and in Irmandade Santa Casa de Misericórdia de Porto Alegre from August 2009 to November 2011, to evaluate the sexual function of women with urinary incontinence that underwent surgical treatment (Burch or sling procedure). The sample comprised 38 women that answered the FSFI questionnaire before operation and six months after the intervention. Results: Thirty-eight women were included in the study and signed an informed consent term. Mean age was 48.3 years; all were sexually active, had studied for at least eight years (65.8%), had steady partners whose mean age was 54 years and with whom they had lived for a mean 22.5 years. The desire and arousal domains improved significantly after surgery for all the women included in the study. Conclusions: The patients that had cystocele had an improvement in sexual function in the discomfort and pain domain.
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2

Darski, Caroline. "Associação entre a musculatura do assoalho pélvico e a função sexual de mulheres com diferentes tipos de incontinência urinária." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/151491.

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Introdução: Incontinência Urinária (IU) é comum na população feminina afetando um terço das mulheres adultas, podendo comprometer sua função sexual (FS). Ainda há controvérsia sobre o impacto da IU sobre a FS. A associação da FS e da funcionalidade da MAP é uma questão relevante que necessita aprofundamento. Objetivo: Comparar a FS de mulheres com Incontinência Urinária de Esforço (IUE) e Incontinência Urinária Mista (IUM), e correlacionar a funcionalidade da musculatura do assoalho pélvico (MAP) à FS destas mulheres. Método: Observacional e transversal, n=61 mulheres, de 30 a 70 anos que tiveram relação sexual nos últimos 12 meses. As participantes foram classificadas em dois grupos: IUE (n=22) E IUM (n=39). A avaliação foi constituída por ficha de anamnese, biofeedback pressórico, escala PERFECT, e questionário PISQ-12. A análise estatística foi realizada através do teste Shapiro-Wilk para verificar a normalidade dos dados. Para comparação dos dados foi utilizado o teste T de amostras independentes e o teste U de Mann-Whitney. Para correlação foi utilizado o teste de Correlação de Spearman. O nível de significância adotado foi de 5%. Resultados: Diferença significativa na paridade e duração da queixa entre os grupos; na comparação do escore total do PISQ-12 e no domínio físico; nos itens P e F da escala PERFECT. Não houve correlação significativa entre a CVM Média e o Escore Total PISQ-12. Conclusão: Não foi demonstrado correlação entre a função da MAP e a FS nos grupos. Porém, houve diferença significativa entre a FS nos grupos.
Introduction: Urinary Incontinence (UI) is common among the female population. It affects one third of adult women and can compromise their sexual function (SF). There are still controversy about the impacts of UI on the SF. The association of the SF and the functionality of the pelvic floor muscles (PMF) is a relevant issue that needs to be better comprehended. Goal: Comparing the SF of women with Stress Urinary Incontinence (SUI) and Mixed Urinary Incontinence (MUI), and correlating these women’s PMF functionality to their SF. Method: Observational and cross-sectional, n=61 women aged 30 to 70 yo, who had had sexual relations in the last 12 months. The participants were divided into two groups: SUI (n=22) and MUI (n=39). The assessment consisted of the anamnesis record, pressure biofeedback, PERFECT scale and the PISQ-12 questionnaire. Statistical analysis was carried out using the Shapiro-Wilk test to verify the normality of the data. The independent t-test and the Mann-Whitney U test were used for data comparison. Spearman’s rank correlation was used to correlate data. The adopted level of significance was 5%. Results: Significant difference between the groups regarding the parity and duration of complaints; the PISQ-12 total score and the physical domain; the items Power-Pressure and Fast of the PERFECT scale. There was no significant correlation between the Maximum Voluntary Contraction (MVC) and the PISQ-12 total score. Conclusion: The tests did not find a correlation between the PFM functions and the SF in the groups. However, there was a significant difference in the SF between groups.
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3

Mandahl, Josefin, and Emma Thingvall. "Rehabilitering av urininkontinens och sexuell dysfunktion för en förbättrad livskvalitet : En litteraturstudie om män med prostatacancer." Thesis, Uppsala universitet, Institutionen för folkhälso- och vårdvetenskap, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-292586.

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Bakgrund: Prostatacancer är den vanligaste cancerformen i Sverige. Urininkontinens och sexuell dysfunktion är vanligt förekommande efter prostatacancerbehandling. Tidigare forskning har visat att urininkontinens och sexuell dysfunktion försämrar livskvaliteten. Syfte: Att kartlägga vilka typer av rehabilitering som finns för män med prostatacancer gällande sexuell dysfunktion och urininkontinens samt att belysa rehabiliteringsbehov som inte tillgodoses. Metod: Litteraturstudie. Tio vetenskapliga originalartiklar inkluderades; åtta med kvantitativ metod och två med kvalitativ metod. Resultat: Det fanns flera olika typer av bäckenbottenträning för att fysiskt rehabilitera urininkontinens. Bäckenbottenträningen minskade urininkontinensen i samtliga studier. Ett samband mellan minskad urininkontinens efter bäckenbottenträning och en förbättrad livskvalitet hittades. Männen hittade strategier för att psykosocialt anpassa sig till sin urininkontinens. Bäckenbottenträningen gav ingen betydande förbättring av sexuell dysfunktion.  Den psykosociala rehabiliteringen som finns vid sexuell dysfunktion är patientinformation, samtal i vården, gruppterapi, stödgrupper och par-kommunikation. Slutsats: Alla typer av bäckenbottenträning minskade urininkontinensen. På grund av den emotionella och sociala påverkan som urininkontinensen har kvarstår ett behov av psykosocial rehabilitering. Ingen evidens hittades för att bäckenbottenträning förbättrar sexuell dysfunktion. Mer forskning efterfrågas för att hitta fysiska rehabiliteringsmetoder vid sexuell dysfunktion. Psykosocial rehabilitering hjälpte männen att anpassa sig till den sexuella dysfunktionen. Dock finns ett behov av ett sammanställt program med olika typer av psykosocial rehabilitering som alla prostatacancerpatienter kan erbjudas.
Background: Prostate cancer is the most common form of cancer in Sweden. Urinary incontinence and sexual dysfunction are the general problems caused by prostate cancer treatment. Previous research has shown that quality of life is affected by urinary incontinence and sexual dysfunction. The aim: To review available rehabilitation in urinary incontinence and sexual dysfunction for men with prostate cancer, and to find rehabilitation needs that were not met in these men. Method: Literature review. Ten articles were included; eight quantitative and two with qualitative method. Results: Several types of pelvic floor muscle training were found to physically rehabilitate urinary incontinence. Pelvic floor muscle training improved urinary incontinence in all studies. A correlation between improved urinary incontinence after pelvic floor muscle training and higher quality of life was found. The men found strategies to psychosocially adjust to urinary incontinence. Pelvic floor muscle training was not effective in rehabilitating sexual dysfunction.  Patient information, consultations, group therapy, support groups and spousal communication was found to be psychosocial rehabilitation methods of sexual dysfunction. Conclusion: All pelvic floor muscle training decreased urinary incontinence. Because of the emotional and social impact of urinary incontinence a need for psychosocial rehabilitation remains. No evidence supports that pelvic floor muscle training improves sexual dysfunction. More research is required in finding physical rehabilitation methods for sexual dysfunction. Psychosocial rehabilitation helped the men to adjust to sexual dysfunction. But there is a need to assemble a program consisting of several types of psychosocial rehabilitation that can be given to all prostate cancer patients.
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4

Ballout, Suha. "The Effects of Age, Ethnicity, Sexual Dysfunction, Urinary Incontinence, Masculinity, and Relationship with the Partner on the Quality of Life of Men with Prostate Cancer." FIU Digital Commons, 2013. http://digitalcommons.fiu.edu/etd/978.

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Prostate cancer, the leading cause of cancer in men, has positive survival rates and constitutes a challenge to men with its side effects. Studies have addressed the bivaritate relationships between prostate cancer treatment side effects masculinity, partner relationship, and quality of life (QOL). However, few studies have highlighted the relationships among prostate cancer treatment side effects (i.e., sexual dysfunction, urinary incontinence), masculinity, and relationship with the partner together on QOL in men. Most studies were conducted with predominately Caucasian sample of men. Miami is a unique multiethnic setting that hosts Cuban, Columbian, Venezuelan, Haitian, other Latin American and Caribbean communities that were not represented in previous literature. The purpose of this study was to examine relative contributions of age, ethnicity, sexual dysfunction, urinary incontinence, masculinity, and perception of the relationship with the partner on the quality of life in men diagnosed with prostate cancer. Data were collected using self administered questionnaires measuring demographic variables, sexual and urinary functioning (UCLA PCI), masculinity (CMNI), partner relationship (DAS), and QOL (SF-36). A total of 117 partnered heterosexual men diagnosed with prostate cancer were recruited from four urology clinics in Miami, Florida. Men were 67.47 (SD = 8.42) years old and identified themselves to be of Hispanic origin (54.3 %, n = 63). Findings demonstrated that there was a significant moderate negative relationship between urinary and sexual functioning of men. There was a significant strong negative association between men’s perceived relationship with partner and masculinity. There was a weak negative relationship between the partner relationship and QOL. Hierarchal multiple regression showed that the partner relationship (β = -.25, t (91) = -2.28, p = .03) significantly contributed overall to QOL. These findings highlight the importance of the relationship satisfaction in the QOL of men with prostate cancer. Nursing interventions to enhance QOL for these men should consider strengthening the relationship and involving the female partner as an active participant.
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5

Adams, Michael John. "Sexual and reproductive health problems among Aboriginal and Torres Strait Islander males." Thesis, Queensland University of Technology, 2007. https://eprints.qut.edu.au/16599/1/Michael_John_Adams_Thesis.pdf.

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Compared to males in almost any social group in all affluent nations, Australia's Aboriginal and Torres Strait Islander men suffer from substantially more serious illnesses and early death. To date, research done by or in collaboration with Indigenous communities has revealed the extent of the problems that arise from diabetes, heart disease, hypertension, cancers, respiratory diseases, psychological disorders, accidental injuries, violence and other causes. Reproductive health, however, rarely has been studied among Indigenous men. To date, research in this field has been limited mainly to studies of sexually transmitted infections. No data has been published on Aboriginal men's symptoms of prostate disease or erectile dysfunction, nor has the clinical screening and treatment of these disorders among these men been assessed. In-depth search of the worldwide web demonstrated that little information on these issues was available from other Indigenous populations. It does appear that Indigenous men in Australia, New Zealand and North America are less likely than European-ancestry men to die from prostate cancer, or for living cases to be recorded on cancer registries. This may arise because Indigenous men genuinely have a lower risk, or because they are not captured by official statistics, or because they do not live long enough to develop severe prostate disease. We also know very little about other reproductive health problems such as sexual dysfunction and specifically erectile difficulties. One reason for our scant knowledge is that research mainly relies on self-report of sensitive information. The aim of the research study was to improve the understanding of sexual and reproductive health problems experienced by Indigenous men. This is best gathered by Aboriginal males who are inside the culture of middleaged and older Indigenous men, but until now this has not been attempted. In this study we adopted the World Health Organization (WHO) definitions for Reproductive and Sexual Health (WHO, 2001). Thus, we consider reproductive system disorders (prostate disease, erectile dysfunction) and related health care-seeking, and also men's perceptions about a "satisfying and safe sexual life". The methodology was framed within an Aboriginal and Torres Strait Islander research protocol that advocates respect for cultural, social and community customs. A mixed method design combined qualitative inquiry (4 focus groups and 18 in-depth interviews) and quantitative survey (n=301) involving men living in remote, rural and urban communities (Tiwi Islands, Darwin and north and south-east Queensland). Survey data were compared to recently published self-reports from 5990 randomly selected men aged over 40 years in Australia (Holden et al., 2005, The Lancet, 366, 218-224. The qualitative interviews revealed that most men were silent about reproductive health. They were unwilling to reveal their inner feelings to wives or partners, and they were unwilling to discuss such issues with doctors and other health care workers. Men's reaction to sexual difficulties included shame, denial, substance abuse and occasionally violence. On a positive note many men said they want to learn about it, so they understand how to cope with such problems. The Indigenous men reported symptoms of erectile dysfunction at least as much as non-Indigenous men in other Australian studies. Bivariate analysis showed that erectile dysfunction was correlated with many health and lifestyle variable. However multivariate analysis revealed that only three factors significantly predicted ED: presence of chronic disease, presence of pain when working, and living in a remote geographic location The quantitative survey data indicate that Indigenous men have more symptoms of prostate disease than non-Indigenous men. The syndrome appears to be poorly managed in clinical practice (e.g. rates of PSA testing and digital-rectal examination are only one-third the rate reported by non-Aboriginal men, despite equivalent likelihood of GP visits). The research study adds to the literature by providing better insight and depth into the issues impacting on Aboriginal and Torres Strait Islander males experiencing reproductive and sexual health difficulties. It also provides a platform to undertake comprehensive research with Aboriginal and Torres Strait Islander men to explore a wider spectrum of questions in this important but neglected area. Implications for education of primary healthcare workers and community-based awareness campaigns for Indigenous males are discussed. Most of all, this study revealed "layers" of silence around sexual and reproductive health of Indigenous men. This includes silence in the scientific establishments in health services, and in the community. It is hoped that this study puts the voices of the men forward to help to break down this silence.
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6

Adams, Michael John. "Sexual and reproductive health problems among Aboriginal and Torres Strait Islander males." Queensland University of Technology, 2007. http://eprints.qut.edu.au/16599/.

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Compared to males in almost any social group in all affluent nations, Australia's Aboriginal and Torres Strait Islander men suffer from substantially more serious illnesses and early death. To date, research done by or in collaboration with Indigenous communities has revealed the extent of the problems that arise from diabetes, heart disease, hypertension, cancers, respiratory diseases, psychological disorders, accidental injuries, violence and other causes. Reproductive health, however, rarely has been studied among Indigenous men. To date, research in this field has been limited mainly to studies of sexually transmitted infections. No data has been published on Aboriginal men's symptoms of prostate disease or erectile dysfunction, nor has the clinical screening and treatment of these disorders among these men been assessed. In-depth search of the worldwide web demonstrated that little information on these issues was available from other Indigenous populations. It does appear that Indigenous men in Australia, New Zealand and North America are less likely than European-ancestry men to die from prostate cancer, or for living cases to be recorded on cancer registries. This may arise because Indigenous men genuinely have a lower risk, or because they are not captured by official statistics, or because they do not live long enough to develop severe prostate disease. We also know very little about other reproductive health problems such as sexual dysfunction and specifically erectile difficulties. One reason for our scant knowledge is that research mainly relies on self-report of sensitive information. The aim of the research study was to improve the understanding of sexual and reproductive health problems experienced by Indigenous men. This is best gathered by Aboriginal males who are inside the culture of middleaged and older Indigenous men, but until now this has not been attempted. In this study we adopted the World Health Organization (WHO) definitions for Reproductive and Sexual Health (WHO, 2001). Thus, we consider reproductive system disorders (prostate disease, erectile dysfunction) and related health care-seeking, and also men's perceptions about a "satisfying and safe sexual life". The methodology was framed within an Aboriginal and Torres Strait Islander research protocol that advocates respect for cultural, social and community customs. A mixed method design combined qualitative inquiry (4 focus groups and 18 in-depth interviews) and quantitative survey (n=301) involving men living in remote, rural and urban communities (Tiwi Islands, Darwin and north and south-east Queensland). Survey data were compared to recently published self-reports from 5990 randomly selected men aged over 40 years in Australia (Holden et al., 2005, The Lancet, 366, 218-224. The qualitative interviews revealed that most men were silent about reproductive health. They were unwilling to reveal their inner feelings to wives or partners, and they were unwilling to discuss such issues with doctors and other health care workers. Men's reaction to sexual difficulties included shame, denial, substance abuse and occasionally violence. On a positive note many men said they want to learn about it, so they understand how to cope with such problems. The Indigenous men reported symptoms of erectile dysfunction at least as much as non-Indigenous men in other Australian studies. Bivariate analysis showed that erectile dysfunction was correlated with many health and lifestyle variable. However multivariate analysis revealed that only three factors significantly predicted ED: presence of chronic disease, presence of pain when working, and living in a remote geographic location The quantitative survey data indicate that Indigenous men have more symptoms of prostate disease than non-Indigenous men. The syndrome appears to be poorly managed in clinical practice (e.g. rates of PSA testing and digital-rectal examination are only one-third the rate reported by non-Aboriginal men, despite equivalent likelihood of GP visits). The research study adds to the literature by providing better insight and depth into the issues impacting on Aboriginal and Torres Strait Islander males experiencing reproductive and sexual health difficulties. It also provides a platform to undertake comprehensive research with Aboriginal and Torres Strait Islander men to explore a wider spectrum of questions in this important but neglected area. Implications for education of primary healthcare workers and community-based awareness campaigns for Indigenous males are discussed. Most of all, this study revealed "layers" of silence around sexual and reproductive health of Indigenous men. This includes silence in the scientific establishments in health services, and in the community. It is hoped that this study puts the voices of the men forward to help to break down this silence.
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7

Iema, Georgia Mayumi Aoki. "Impacto e adaptação às alterações urinárias e sexuais decorrentes da prostatectomia radical." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-24022016-163052/.

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A prostatectomia radical é o método terapêutico mais utilizado no tratamento do câncer de próstata localizado. O objetivo deste estudo é avaliar a readaptação urinária e sexual no período pós- operatório. Método: Foram estudados 46 homens tratados por Prostatectomia Radical à quatro tempos: pré-cirurgia e após três meses; seis meses e um ano após cirurgia, através dos seguintes instrumentos: escala adaptativa operacionalizada redefinida- (EDAO-R); questionário de avaliação da disfunção sexual masculina - (QSM); questionário de incontinência urinária - (ICIQ-SF) e o questionário de comprometimento cognitivo - (MEEM). Em um ano de estudo a análise estatística avaliou quantitativamente a eficácia adaptativa em quatro setores, estruturados nos seguintes pressupostos: Afetivo-Relacional (A-R); Produtividade (Pr); Orgânico (Or) e Socio-Cultural (S-C). Resultados: Encontrou-se diferença significativa nos valores da adequação diagnóstica pela EDAO-R entre o momento 3 (6 meses de PR: G1 8,7%; G2 15,2%; G3 17,4%; G4 28,3%; G5 30,4%) e o momento 4 (1 ano de PR: G1 8,7%, G2 17,4%; G3 23,9%, G4 19,6%; G5 30,4%) em relação ao momento 1(précirurgíco: G1 28,3%; G2 17,4%; G3 26,1%; G4 17,4%, G5 10,9%). E no momento 3 (6 meses de PR: G1 8,7%; G2 15,2%; G3 17,4%; G4 28,3%; G5 30,4%) houve um aumento significativo em relação ao momento 2 (3 meses de PR: G1 10,9%; G2 17,4%; G3 37,0%; G4 17,4%; G5 17,4%). O ICIQ-SF diagnosticou diferenças significativas entre os todos os momentos (p < 0,001). O MEEM resultou no momento 2 (um ano de PR) com valores significativamente maiores que os apresentados no momento 1 pré-cirúrgico (p=0,001). O QS-M revelou no momento pré-cirúrgico que 80,5% dos pacientes se encontravam num escore de bom a excelente em relação ao desempenho sexual e que 19,5% se encontravam num escore de desfavorável a regular. No momento 4 (um ano de PR), os achados foram: 21,7% dos pacientes classificados na categoria de bom a excelente; 54,4%, na categoria de ruim a desfavorável e 23,9%, na categoria de nulo a ruim. Conclusão: Os homens submetidos à PR durante o período do estudo ficaram comprometidos na organização e na readaptação às alterações urinárias e sexuais decorrentes do tratamento
Radical prostatectomy (RP) is the most widely used therapeutic method in the treatment of localized prostate cancer. The aim of this study is to evaluate the urinary and sexual rehabilitation in the postoperative period. Methods: A study was done of 46 men treated with radical prostatectomy at four time intervals: pre-surgery, three months, six months and one year postsurgery. The following instruments were used: Revised Operational Adaptive Diagnostic Scale - (ROADS); questionnaire for the assessment of male sexual dysfunction - (QS -M); International Consultation on Incontinence Questionnaire - Short Form (ICIQ -SF) and the cognitive impairment test (Mini-Mental State Examination - MMSE). In a year of study the statistical analysis quantitatively evaluated the adaptive efficacy in four sectors, structured in the following assumptions: Affective - relational (AR); Productivity (Pr); Organic (Or) and Socio-Cultural (S- C). Results: There was a significant difference in the values of diagnostic suitability for the ROADS between time interval 3 (6 months of RP: G1 8.7%; G2 15.2%; G3 17.4%; G4 28.3%; G5 30.4%) and time interval 4 (1 year RP: G1 8.7%; G2 17.4%; G3 23.9%; G4, 19.6%; G5 30.4%) relative to time interval 1 (pre-surgical: G1 28.3%; G2 17.4%; G3 26.1%; G4 17.4%; G5 10.9%). Additionally at time interval 3 (6 months of RP: G1 8.7%; G2 15.2%; G3 17.4%; G4 28.3%; G5 30.4%) there was a significant increase compared to the second time interval (RP 3 months: G1 10.9%; G2 17.4%; G3 37.0%; G4 17.4%; G5 17.4%). The ICIQ-SF diagnosed significant differences between all four time intervals (p < 0.001). The MMSE resulted in time interval 2 (1year os RP) having significantly higher values than those presented pre-surgery in time interval 1 (p = 0.001). The QS-M revealed that 80.5% of the patients were found to have a good to excellent score in relation to sexual performance and that 19.5% had an unfavorable to regular score prior to surgery. At time interval 4 (one year PR), the findings were: 21.7% of patients were classified as good to excellent; 54.4% were classified as bad to unfavorable and 23.9% were in the null to bad category. Conclusion: The men submitted to PR during the study period were committed to the organization and rehabilitation of the urinary and sexual changes due to treatment
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Pinto, Antonio Cardoso. ""O impacto da correção cirúrgica da incontinância urinária aos esforços pela técnica de suporte suburetral na vida sexual de mulheres submetidas a esse tratamento"." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-03062006-135123/.

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Objetivo: Avaliar o impacto da incontinência urinária na vida sexual de mulheres, com indicação de tratamento cirúrgico pelas técnicas de suporte suburetral, assim como identificar se a correção dessa moléstia pode representar evolução na vida sexual dessas pacientes, resultando em melhora na sua qualidade de vida. Casuística e Métodos: Foram estudadas 64 mulheres heterossexuais com indicação para o tratamento de incontinência urinária aos esforços pelas técnicas de suporte suburetral no período de agosto de 2001 a setembro de 2002, através do questionário “The Female Sexual Function Index (FSFI)”, modificado pela introdução de uma questão para avaliar o impacto da perda urinária, aplicado no pré-operatório e seis meses após a realização do procedimento cirúrgico. Resultado: Das 64 pacientes submetidas a tratamento cirúrgico de incontinência urinária aos esforços pela técnica de suporte suburetral, 60,94% tinham atividade sexual, enquanto 39,06% não a apresentavam. Ressalte-se que a faixa etária influenciou estatisticamente o resultado. Das pacientes sem atividade sexual, 44% alegaram a ausência de parceiro como a causa, enquanto 40% atribuíram a ausência de atividade sexual à diminuição da libido. Do grupo de pacientes com atividade sexual, 59% tinham perdas urinárias no ato sexual. Destas, 87% apresentavam perdas urinárias em metade ou mais de suas relações sexuais. Na avaliação dos domínios desejo, excitação, lubrificação, orgasmo, satisfação e dor, bem como na totalização das pontuações comparativas entre o pré-operatório e seis meses após a realização do tratamento cirúrgico, não encontramos diferença estatisticamente significativa. A análise da pontuação das perdas urinárias durante o ato sexual, porém, foi significativamente melhor no pós-operatório. A avaliação dos diversos domínios não foi significativamente diferente quando comparamos o tipo de suporte utilizado (autólogo ou sintético) no ato operatório. Conclusão: a) A faixa etária exerce influência na Atividade Sexual. b) A perda urinária na atividade sexual é freqüente em pacientes com incontinência urinária aos esforços, tendo impacto negativo na sua qualidade sexual. c) A cirurgia apresentou índices de cura superiores a 90% nas perdas urinárias durante o ato sexual e não prejudicou a atividade sexual das pacientes. d) A melhora da função sexual, quando ocorreu, foi subjetivamente relacionada com o aumento desejo sexual, e não decorrente da redução das perdas urinárias durante o relacionamento sexual após tratamento cirúrgico. e) O tipo de suporte utilizado (autólogo ou sintético) não exerce influência nos resultados obtidos. f) As pacientes que se curaram da incontinência urinária aos esforços não apresentaram melhora em relação à função sexual.
Objective: To evaluate urinary incontinence impact in the sexual life of women with recomendation for surgical treatment by sub-urethral support techniques, as well as to identify if correction of the pathology can represent an improvement on patients´ sexual life, generating better quality of life. Casuistic and Methods: 64 heterosexual women with indication for surgical treatment for stress urinary incontinence through suburethral support techniques were studied from August 2001 to September 2002, through the questionnaire “The Female Sexual Function Index (FSFI)” modified by the introduction of one question to evaluate urinary loss impact, applied in the preoperative period and six months after surgery. Result: Of the 64 patients submitted to surgical treatment for stress urinary incontinence by sub-urethral support techniques, 60,94% had regular sexual activity, while 39,06% didn't, being age a statistically significant factor in this result. Of the patients without sexual activity, 44% stated that the absence of a partner was the cause, while 40% attributed sexual abstinence to low desire. In the group of patients with sexual activity, 59% had urinary loss during sexual intercourse, and, of those, 87% had urinary losses in half or more of their sexual relations. Regarding evaluation of desire, stimulation, lubrication, orgasm, satisfaction and pain, as well as sum the scores comparatively between the preoperative period and six months after surgical treatment, there was no statistically significant difference; however the analysis of scores for urinary losses during sexual intercourse were significantly better in the postoperative period. There was not statistically significant difference with respect to all the factors above when we compared the kind of sub-urethral support employed (autologue vs. synthetic). Conclusions: a) Age influences Sexual Activity. b) Urinary loss during sexual activity is frequent in patients with stress urinary incontinence and it is associated with a negative impact in the quality of the relation. c) Surgery was responsible for cure rates above 90% to urinary losses during sexual intercourse. d) The sub-urethral support surgery did not jeopardize the sexual activity of our patients. d) The kind of sub-urethral support employed (autologue or synthetic) does not have any influence on the results. f) The patients that were cured of the stress urinary incontinence did not present improvement regarding the sexual function.
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9

Hedestig, Oliver. "Att leva med lokaliserad prostatacancer : "oss män emellan"." Doctoral thesis, Umeå universitet, Strålningsvetenskaper, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-898.

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The purpose of this thesis is to explore how men experience living with localized prostate cancer. It includes four substudies carried out between 1997 and 2005. To gather data, the men were interviewed at home and the interviews were recorded. The men (n=27; ages 60-70) who participated in the substudies had a PSA ≤10 ng/ml at the time of diagnosis, and had what is known as low-risk prostate cancer. Seven of the men chose to “wait and see” how the disease would progress after receiving the diagnosis. Twenty men chose curative treatment (10 men external radiation therapy, 10 men radical surgery). The interviews were analyzed using a phenomenological hermeneutical method inspired by the philosophy of Paul Ricoeur, and qualitative content analysis. Men who live with localized prostate cancer perceive the disease as life-threatening, unpredictable, and without early symptoms, which creates a sense of uncertainty, worry, anxiety, despair, and fear of death. Men primarily share perceptions of the disease and treatment with their wives and relatives, as well as with other men in the same situation. They avoid talking about their illness, and keep their innermost thoughts about their disease, prognosis, and the future to themselves. The choice to share their thoughts and feelings only sparingly with others is related in part to the perceived stigmatization of the diagnosis, as well as to consideration for friends and family. The men report that external radiation therapy and radical surgery have negative side effects such as erectile dysfunction, urinary incontinence, and intestinal leakage. They describe the side effects as socially isolating; for example, urinary leakage can require a change of incontinence pads and clothing, and they feel that they smell bad. Men with erectile dysfunction describe themselves as maimed, and their sex lives have changed or disappeared. They report a change in their self-esteem and identity as men and they long for life as it was before the diagnosis, when they felt they had control over their bodily functions. A few men describe a sense of being literally and figuratively “exposed” when they are undressed for examinations or participate in discussions with female doctors and nurses about their erectile dysfunction. They do not describe this perception in the same way with respect to contact with male personnel. In the new situation after treatment, men try to regain a perceived sense of control in their daily lives, over the disease and the effects of treatment. They experience a sense of control over the disease through regular PSA tests; the implications of regular PSA tests can be interpreted as a life preserver in an uncertain world, considering that at the time they were diagnosed they had no symptoms and only had a PSA elevation. The PSA is important for this sense of control, and each PSA test is preceded by tense expectation. The PSA level is described as a reliable expression of the medical condition. The men cannot trust that their own perception of feeling healthy means that the disease is under control. Low and stable PSA levels over a long period of time give a sense of safety, security, and control over the situation. If the PSA climbs, the men feel that despite everything, they have caught it in time for further treatment. Discussions with other men with prostate cancer are also described as a way of having control over the situation. The men's endeavor to reconcile themselves to the new situation can be understood as a process, where they describe various strategies which can be used to forget the “cancer perspective” and achieve a perception of safety and security. Reconciliation with a new situation can be interpreted as a reorientation after the trauma of the cancer diagnosis. The study results show that the men are restrained in communicating their needs to others, which can be interpreted as their having a greater need for support and information than indicated by their signals. Having an internal image of what a man should be like can be an obstacle to showing these needs.
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10

Neto, Khaled Ahmed Taha. "Perfil da sexualidade e dos sintomas do trato urinário inferior em idosos não institucionalizados." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-05102016-125237/.

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As disfunções urinárias ou sexuais do idoso são subnotificadas. Porém, são de alta prevalência e associadas a diversos prejuízos psicossociais. O presente estudo visa à identificação da prevalência dessas condições por meio de questionários. Utilizou-se o Androgen Deficiency in Aging Male (ADAM) para avaliação de função sexual do homem, questões sobre função sexual feminina e masculina e, o International Prostate Symptom Score (IPSS) para avaliação de função urinária masculina e feminina. Temos o objetivo de realizar uma investigação nos indivíduos não institucionalizados, acima de 60 anos de idade, para obtermos dados referentes à sua saúde sexual e urinária nas cidades: São Paulo, Campinas, Santo André, São Bernardo do Campo, São Caetano e Londrina. Foram distribuídos cerca de 6000 questionários, sendo utilizados para estudo 3425, com 1575 homens e 1850 mulheres. Em relação ao ADAM, obtivemos 92,49% dos 1385 avaliados com suspeita de apresentarem distúrbio androgênico do envelhecimento masculino (DAEM). Quanto à função sexual masculina, evidenciamos que 383 (32,19%) apresentavam queixas eretivas, 458 (37,54%) de ejaculação precoce e 790 (59,13%) admitiram a necessidade de tratamento para melhorar o desempenho sexual. Quanto à função sexual feminina, 1300 (74,07%) não praticam relação sexual e os principais motivos foram: falta de parceiro, falta de desejo sexual e problema de saúde do parceiro. Além disso, 988 (78,41%) das mulheres que não têm relação sexual admitem estar bem assim e não querem sexo e mais importante: aproximadamente 21% dessas gostariam de ter relação sexual. Quanto à qualidade da relação sexual feminina, 272 (64,92%) acham a relação boa para ambos, 105 (25,06%) boa só para o parceiro e 33 (7,88%) ruim para ambos. Em relação ao IPSS masculino, observamos piora gradual no padrão miccional com o aumento da idade, dos sintomas moderados e graves, principalmente após os 75 anos, sendo os mais prevalentes: nictúria, urgência miccional e aumento da frequência urinária. Quanto ao IPSS feminino, notamos que, mesmo após os 80 anos, a maioria das mulheres (53,37%) apresenta sintomas leves relacionados à disfunção miccional; com o aumento da idade, ocorre um aumento gradual do resultado do IPSS, relacionado com os sintomas moderados e graves, sendo que o pico ocorre após os oitenta anos. Sendo assim, devido ao grande número de distúrbios sexuais e urinários encontrados, deixamos um alerta para que um maior número de medidas de Saúde Pública sejam implantadas, melhorando promover uma melhor qualidade de vida nessa população idosa
Urinary or sexual dysfunction in the elderly are underreported. However, are highly prevalent and associated with various psychosocial damage. This study aims to identify the prevalence of these conditions. We used the Androgen Deficiency in Aging Male (ADAM) to assess sexual function of men, questions of male and female sexual function, and the International Prostate Symptom Score (IPSS) for evaluation the urinary function. The aim is to carry out an investigation in non-institutionalized individuals over 60 years of age, to obtain data on its sexual and urinary health in: São Paulo, Campinas, Santo André, São Bernardo do Campo, São Caetano and Londrina. They were distributed about 6,000 questionnaires being used to study 3425, with 1575 men and 1850 women. Compared to ADAM, obtained 92.49% of the 1385 evaluated suspected of presenting androgen disorder of aging male (ADAM). As for the male sexual function, we showed that 383 (32.19%) had erective complaints, 458 (37.54%) of premature ejaculation and 790 (59.13%) admitted the need for treatment to improve sexual performance. As for the female sexual function, 1300 (74.07%) did not practice sexual intercourse and the main reasons were: lack of partner, lack of sexual desire and partner health problem. In addition, 988 (78.41%) of women who haven\'t sexual intercourse admit to being like that and not want sex and, more importantly, about 21% of them would like to have sexual intercourse. As for the quality of the female sex, 272 (64.92%) think the relation is good for both, 105 (25.06%) only good for the partner and 33 (7.88%) bad for both. IPSS when compared to males, we see gradual worsening of urinary pattern with increasing age, related with the moderate and severe symptoms, especially after 75 years, being the most prevalents: nocturia, urinary urgency and urinary frequency. As for the female IPSS, we note that even after 80 years, the majority of women (53.37%) have mild symptoms related to voiding dysfunction; with increasing age there is a gradual increase in the result of the IPSS, associated with moderate and severe symptoms, where the peak occurs after the age of eighty. Thus, due to the large number of sexual and urinary disorders found, left a warning to a greater number of public health measures are implemented, improving promote a better quality of life in this elderly population
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11

Pitre, Deepali. "Oxidative mechanisms in diabetes related urinary bladder dysfunction." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1060880772.

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12

Vijaya, Gopalan. "Nerve growth factor and lower urinary tract dysfunction." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/24860.

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The polypeptide nerve growth factor (NGF) has been explored extensively over the span of six decades since its detection with amazing discoveries from its neurotrophic action to tissue healing properties. In lower urinary tract there is substantial evidence linking NGF and lower urinary tract dysfunction (LUTD). Over recent years the role of urinary NGF [UrNGF] in diagnosing LUTD as well as monitoring treatment response has been investigated extensively. However, the available studies report conflicting data regarding an association between lower urinary tract symptoms [LUTS] and UrNGF, and there is limited evidence for the validity and reliability of urinary NGF assays. In a quest to explore the role of UrNGF as a LUTS biomarker, levels were measured in patients with LUTD, prolapse and asymptomatic controls. This thesis hypotheses that measurement of NGF is of no value in LUTD and prolapse. Therefore the aims were to evaluate the diagnostic and discriminant ability of UrNGF measurement in LUTD and to test the reliability of NGF assays. The other objective was to study the association between UrNGF levels and cystoscopic and histology findings of bladder inflammation in women with overactive bladder [OAB] to explore the link between NGF and inflammation. Change in UrNGF levels after cystocele repair was studied, since bladder wall stretching has been postulated as one of the causes for increased NGF levels. Finally UrNGF levels before and after antibiotic treatment for refractory OAB were measured with the aim to evaluate its role to assess treatment response. On test retest reliability analysis of 13 samples there was almost perfect reliability with an Intraclass correlation coefficient of 0.889; 95%[C.I=0.676-0.965; p<0.001]. Urinary NGF was significantly but non-specifically increased in symptomatic patients [n=205] when compared to controls [n=31](13.33 vs. 2.05 ng NGF/ g Cr, Mann Whitney test; p <0.001) However ROC analysis, demonstrated poor discriminant ability between either different symptomatic groups or urodynamic groups. Using a cut off of 13.0 ng NGF/ g creatinine the test provides a sensitivity of 81%, but a specificity of only 39 % for overactive bladder. UrNGF levels were not associated with cystoscopic or histology findings of inflammation and did not improve after anterior repair in women who had an improvement in OAB symptoms. However in the study done to explore the role of urinary NGF as a biomarker to assess treatment response, NGF levels were found to decrease significantly after six weeks of antibiotic therapy in women with refractory OAB symptoms [n=35 patients] (Wilcoxon Signed rank test; p=0.015). This was associated with improvement in OAB symptoms. UrNGF does not appear to be a good diagnostic biomarker but may have a role as a marker of treatment response, hence may have limited role in assessment of women with LUTD.
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13

Pitre, Deepali Anant. "Oxidative mechanisms in diabetes related urinary bladder dysfunction." Columbus, Ohio : Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1060880772.

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Thesis (Ph. D.)--Ohio State University, 2003.
Title from first page of PDF file. Document formatted into pages; contains xx, 400 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: John A. Bauer, College of Pharmacy. Includes bibliographical references (p. 397-400).
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14

Louizos, Connie Celest. "Sexual Inhibition and Sexual Excitation in Erectile Dysfunction." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/15843.

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Erectile dysfunction (ED) is a common problem with many aetiologies. The development of phosphodiesterase type 5 inhibitors (PDE5Is) has offered a highly efficacious therapeutic approach to the treatment of ED. However, a significant number of men fail to respond to medication, and others discontinue its use despite good therapeutic responses. Little is known about the determinants of low PDE5I efficacy or compliance. It is recognised that adequate sexual arousal is necessary in order for PDE5Is to have an effect, but arousability is rarely assessed during the routine therapeutic workup. It is therefore possible that unidentified low arousability contributes to therapeutic failure. The Dual Control Model of Sexual Response offers a theoretical framework for the investigation of sexual excitation and inhibition (which may impact on arousability) that can be undertaken using its associated questionnaire, the sexual excitation/sexual inhibition questionnaire (SIS/SES). The purpose of the studies reported in this thesis was to evaluate how the propensities of sexual excitation and inhibition relate to ED sufferers response to PDE5I therapy. The studies focused on men being treated by general practitioners for apparent psychogenic ED. Four studies were conducted. In the first study, the aim was to investigate whether individual differences in the propensity for sexual inhibition and excitation measured using the SIS/SES questionnaire predicted responses to PDE5Is. The study was based on the hypothesis that men with lower arousability, operationalized as low excitation, would be less responsive to PDE5I then men with higher excitation. Men aged 18 and older (N = 100) who were prescribed PDE5Is for the first time were recruited into the study and assessed at baseline and 3 months as part of their normal course of care. The severity of ED was assessed using the erection function (EF) scale of the International Index of Erectile Function (IIEF), and sexual inhibition and excitation were measured using the SIS/SES questionnaire. The results of this study showed that higher SES and IIEF-EF scores at the beginning of therapy were predictive of a larger improvement in IIEF-EF score in response to therapy. Sexual inhibition scores were not predictive of changes in IIEF-EF scores. The findings suggest that an individual’s propensity for sexual excitation influences their response to PDE5I therapy. In the clinical setting, evaluation of the propensity for sexual excitation may help practitioners determine which of the treatment options available is most likely to have the best result. It is possible that men with lower SES scores should receive PDE5Is at the highest possible dose. The second study evaluated whether the ongoing failure of PDE5I therapy to improve erectile function had an adverse impact on sexual excitation and/or inhibition, and therefore decreased the likelihood of a successful response in the future. Established PDE5I users completed the SIS/SES questionnaire at recruitment and three months later. On the basis of IIEF scores at recruitment, subjects were divided into two groups according to the severity of their ED - mildly affected (M) and mild – moderately affected (MM). SES scores were significantly lower, and SIS1 scores significantly higher in Group MM at recruitment and at three months (P < 0.001). In Group M, SES scores increased (P < 0.005) and SIS1 (P < 0.001) and SIS2 (P = 0.01) scores decreased over the three months of the study. In Group MM, SES scores decreased while SIS1 scores increased over the study period (P < 0.001). The results for Group M showed that men whose EF scores increased were more likely to experience increased SIS2 and decreased SES scores. Analysis of the results using multiple linear regression showed that SIS/SES variables were of little value in predicting erectile function (EF) at recruitment, or change in EF during the study period. This was an unexpected finding, because previous studies have consistently shown a link between SIS1 and IIEF-EF scores. It is possible that sexual excitation and inhibition, although fundamentally traits, may also be influenced by the current state of the patient. The findings of this study suggest that the severity of ED in non-responders influences how the state component of measured excitation and inhibition changes over time, with more severely affected patients experiencing changes that decrease the likelihood of a successful response to PDE5Is in the future. The third study built on the finding reported by Lykins et al (2012) that couples’ similarities in sexual excitation and inhibition predict sexual function in men who were not experiencing clinical ED. The aim was to investigate whether the degree of between-partner similarity or dissimilarity in the propensity for sexual inhibition and excitation in heterosexual couples (N = 189) predicted the severity of ED in patients who had sought treatment for ED. The severity of ED was assessed using the erection function domain of the International Index of Erectile Function (IIEF-EF), and sexual inhibition and excitation were measured, in both men and women, using the SIS/SES questionnaire. Regression analyses showed that men (ß = -0.21, t = -2.9, P = 0.004) and women’s SIS1 scores (ß = -0.42, t = -6.2, P = 0.001), and couple similarity in SES scores (ß = 0.19, t = 3.0, P = 0.002), were significant predictors of IIEF-EF score, and that couple similarity in SIS1 scores negatively predicts IIEF-EF, meaning better erectile function. In other words, lower SIS1 scores at baseline predicted a higher erectile function score on the IIEF-EF. In the fourth study, the aim was to determine whether sexual excitation and inhibition influenced patients’ expectations of the therapeutic response to PDE5Is, and whether those expectations were predictive of the actual therapeutic response. A questionnaire was developed and used to collect data on expectations in eighty men commencing PDE5I therapy, and after three and six months of treatment. At the same time, subjects completed the IIEF, SIS/SES and Beck’s Depression Inventory (BDI). SIS/SES scores were not predictive of scores of any items on the expectations questionnaire, nor was there any evidence of an effect on expectations on changes in IIEF or BDI scores. Although changes in IIEF and BDI scores from recruitment to 3 months were indicative of improved sexual function and less depression, scores on items on the expectations scale decreased, suggesting that expectations were not being met. The items for which scores decreased were the expectation to be prescribed a drug, that the drug would restore the sexual function to normal, would work within 30 minutes of administration, improve patients confidence to engage in sexual activity, and that the medication was the best treatment for ED across the three data collection points. The findings of the study suggested that the education of patients about how PDE5Is should be used was sub- optimal. The findings of these studies suggest that the measurement of sexual inhibition and excitation can provide some information that may be of use in planning PDE5I therapy. Specifically, the capacity to predict the response to medication may enable clinicians to create more realistic expectations in their patients, and therefore decrease the risk of dissatisfaction and discontinuation. If men with low arousability can be identified, it may be possible to implement counselling strategies to address the problem and improve the likelihood of therapeutic success. This concept can be extended to partners, given that these studies have shown that partner similarities predict some of the therapeutic response to PDE5Is.
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15

Baldwin, David Stewart. "Antidepressant drugs and sexual dysfunction." Thesis, University of Southampton, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403830.

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16

Bijos, Dominika Anna. "Integrated physiology of lower urinary tract function and dysfunction." Thesis, University of Bristol, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.684359.

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Lower Urinary tract diseases are an increasing problem in the ageing society, decreasing life quality and increasing cost of care. The underlying pathology of overactive bladder syndrome is not well understood, but has been linked with increased bladder contractility. Contractions of the smooth muscle in the bladder are localized to the bladder wall, but summed up affect the intravesical bladder pressure. In this thesis I explore contraction and movement initiation, propagation and the general bladder tone. Interstitial cells modulate spontaneous bladder activity by affecting initiation of contractions. To characterize them new markers are needed. I show expression of , Anol chloride channels on interstitial cells in juvenile , and adult rat bladder using molecular and immunolabelling techniques and presented data from bioinformatic search confirming expression of Anol in human bladders. In vitro and ex vivo recording showed that Anol blockers reduce phasic activity of rat bladder tissue. In isolated whole organ the frequency of pressure fluctuations was reduced, suggesting a role in the initiation of contractions. Spontaneous phasic activity in strips and whole organs differs between young and adult animals. In young animals, like in pathology, bladders show large amplitude low frequency phasic activity, while adult bladders have low amplitude high frequency contractions. Phasic activity changes are reflected also in the change of the bladder wall movements: from propagating contractions in young to multifocal asynchronous motile areas in adult animals. Propagation of contraction most likely happens via direct connections between the cells - the gap junctions. Blocking gap junctions in bladder tissue strips and isolated whole organ reduced the amplitude of bladder phasic activity. Effects of gap junction blockers on the tension (strips) and pressure (whole organ) measurements are comparable between young and adult animals. Microcontractions and micro elongations combined result in the phasic pressure fluctuations and are sensitive to changes in tone during relaxation by p-adrenoceptor agonist. These results show that bladder phasic activity and motility is composed of motile and non-motile areas, where initiation and propagation of contractions is possible when a bladder has a certain tone. Micromotions are a missing part of the bladder physiology. Chloride channel and gap junction blockers reduced spontaneous phasic activity and are a new direction in bladder disease pharmacology.
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17

Mitchell, Kirstin Rebecca. "Sexual dysfunction : conceptual and measurement issues." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2008. http://researchonline.lshtm.ac.uk/682371/.

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Despite a standard classification and array of self-report questionnaires, there is little consensus about how to define and measure sexual dysfunction. Recently the debate has been influenced by the pharmaceutical industry, leading to an increasingly medicalised view of sexual difficulties. The aim of this thesis was to explore the meaning of sexual (dys)function to those who have and have not experienced sexual difficulties; and to use these meanings to create a conceptual model and population prevalence measure of sexual dysfunction for use in UK community surveys. Thirty-two semi-structured interviews were conducted with individuals recruited from a GP practice, an HIV/AIDS Charity and a Sexual Problems Clinic. The data were analysed using principles derived from Grounded Theory. Variation in individual meaning was expressed in terms of three distinct versions of functional sex - the erotic, the interpersonal and the mechanistic - which framed the purpose of sexual activity, the criteria determining ideal sex, and threats to this ideal. The data highlighted several coping strategies that individuals adopted when their lived reality failed to match their ideal: changing circumstances to fit goals, for instance by seeking a medical cure; changing goals to fit circumstances, for instance by lowering expectations; And living with the gap between ideal and actual experience, for instance by avoiding the problem. Choice of strategy and the likelihood of successful adjustment were influenced by the severity of the problem, causal attributions made about the problem, and the partnership context. Thirty-one potential components of a functioning sex life were identified from the data. Using evidence both from the literature and from this study, 12 of these components were selected for inclusion in a conceptual model of sexual function. This model was transformed into a 19-item draft prevalence measure of sexual dysfunction ready for psychometric testing and validation.
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Prado, Daniela Siqueira. "Práticas obstétricas e influência do tipo de parto em resultados neonatais e maternos em Sergipe." Pós-Graduação em Ciências da Saúde, 2018. http://ri.ufs.br/jspui/handle/riufs/8552.

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Background: Brazil has high frequency of inappropriate obstetric practices and cesarean sections. This procedure may be associated with increased maternal and perinatal morbidity. Objective: to describe practices and interventions used during labor and childbirth and factors associated with such practices and to evaluate the impact of mode of delivery in breastfeeding incentive practices and in neonatal and maternal complications. Methods: A Cohort study was conducted, between june 2015 and april 2017, at the 11 maternity hospitals in Sergipe with 768 puerperal women, interviewed in the first 24 hours after delivery, 45-60 days and 6-8 months after delivery. The associations between good practices and interventions used during labor and delivery with exposure variables were described by simple frequencies, percentages, crude and adjusted odds ratios (ORA) with the confidence interval and the association between breastfeeding incentive practices, neonatal and maternal, both short term and late complications and the exposure variables were evaluated by the relative risk (95% IC) and the Fisher exact test. Results: were fed 10.6% of women and 27.8% moved during labor; non-pharmacological measures for pain relief were performed in 26.1%; the partograph was filled in 39.4% of the charts and the companion was present in 40.6% of deliveries. Oxytocin, amniotomy and analgesia occurred in 59.1%, 49.3% and 4.2% of women, respectively. The delivery occurred in the lithotomy position in 95.2% of the cases, there was episiotomy in 43.9% and Kristeller's maneuver in 31.7%. The factors most associated with cesarean section were the private health sector (ORA = 4.27,95% CI: 2.44-7.47), had higher education (ORA = 4.54,95%CI 2.56 -8.3) and high obstetric risk (ORA = 1.9,95%CI: 1.31-2.74). Private-sector users had a greater presence of the companion (ORA = 2.12,95% CI:1.18-3.79) and analgesia (ORA = 4.96,95% CI:1.7-14.5). The C-section delivery resulted in less skin-to-skin contact immediately after delivery (intrapartum c-section: RR=0.18;95%CI:0.1-0.31 and elective c-section: RR=0.36;95%CI:0.27-0.47) and less breastfeeding within one hour of birth (intrapartum C-section: RR=0.43;95%CI:0.29-0.63 and elective C-section: RR=0.44;95%CI:0.33-0.59). Newborns from elective c-section were less frequently breastfed in the delivery room (RR=0.42;95%CI:0.2-0.88) and stayed less in rooming- in (RR=0.85;95%CI:0.77-0.95). Women who were submitted to intrapartum c-section had greater risk of early complications (RR=1.3;95%CI:1.04-1.64; p=0.037) and sexual dysfunction (RR=1.68;95%CI:1.14-2.48; p=0.027). There was no difference in the frequency of neonatal complications, urinary incontinence and depression according to the mode of delivery. Conclusions: good obstetric practices are poorly performed and unnecessary interventions are frequent, and the factors most associated with cesarean delivery have been the private health sector, higher schooling and high obstetric risk. C-section was negatively associated to breastfeeding incentive practices. C-section after labor increased the risk of early maternal complications and sexual dysfunction, six to eight months after delivery.
Introdução: No Brasil, verifica-se elevada frequência de práticas obstétricas inadequadas e de cesáreas. Este procedimento pode associar-se a aumento de risco de morbidade materna e neonatal. Objetivo: descrever as práticas utilizadas durante o trabalho de parto e parto e fatores associados e avaliar práticas de incentivo à amamentação, complicações neonatais e maternas precoces e tardias segundo tipo de parto. Pacientes e Métodos: estudo tipo coorte, no período de junho de 2015 a abril e 2016, nas 11 maternidades de Sergipe, com 768 puérperas entrevistadas após 6h do parto, 45 a 60 dias e 6 a 8 meses após o parto e análise de dados do prontuário das puérperas e dos recém-nascidos. As associações entre as boas práticas e intervenções utilizadas durante o trabalho de parto e parto com as variáveis de exposição foram descritas em frequências simples, percentuais, razões de chances brutas (OR) e ajustadas (ORA) com o intervalo de confiança e as associações entre as práticas de incentivo à amamentação, as complicações neonatais e maternas precoces e tardias e as variáveis de exposição foram descrias por risco relativo (IC=95%) e pelo teste exato de Fisher. Resultados: alimentaram-se 10,6% das mulheres e 27,8% movimentaram-se durante o trabalho de parto; medidas não farmacológicas para alívio da dor foram realizadas em 26,1%; o partograma estava preenchido em 39,4% dos prontuários e o acompanhante esteve presente em 40,6% dos partos. Ocitocina, amniotomia e analgesia ocorreram em 59,1%, 49,3% e 4,2% das mulheres, respectivamente. O parto ocorreu na posição de litotomia em 95,2% dos casos, houve episiotomia em 43,9% e manobra de Kristeller em 31,7%. Os fatores mais associados à cesárea foram ser do setor privado de saúde (ORA=4,27;95%CI:2,44-7,47), ter maior escolaridade (ORA=4,54;95%CI:2,56-8,3) e alto risco obstétrico (ORA=1,9;95%CI:1,31-2,74). Usuárias do setor privado tiveram maior presença do acompanhante (ORA=2,12;95%CI:1,18-3,79) e analgesia (ORA=4,96;95%CI: 1,7-14,5). Os recém-nascidos de puérperas que se submeteram a cesárea tiveram menor frequência de contato pele a pele com suas mães imediatamente após o parto (cesárea intraparto: RR=0,18;95%CI:0,1-0,31 e cesárea eletiva: RR=0,36;95%CI:0,27-0,47) e mamaram menos na primeira hora de vida (cesárea intraparto: RR=0,43;95%CI:0,29-0,63 e cesárea eletiva: RR=0,44; 95%CI:0,33-0,59). Recém-nascidos de cesárea eletiva foram menos frequentemente colocados para mamar na sala de parto (RR=0,42;95%CI:0,2-0,88) e ficaram em menor frequência em alojamento conjunto (RR=0,85;95%CI:0,77-0,95). As mulheres submetidas a cesárea intraparto tiveram maior risco de complicações precoces (RR=1,3;95%CI:1,04-1,64; p=0,037) e de disfunção sexual (RR=1,68;95%CI:1,14-2,48; p=0,027). Não houve diferença nas frequências de complicações neonatais, incontinência urinária e de depressão segundo tipo de parto. Conclusões: boas práticas obstétricas são pouco utilizadas e intervenções desnecessárias são frequentes e os fatores mais associados à operação cesariana foram ser do setor privado de saúde, ter maior escolaridade e alto risco obstétrico. A cesárea associou-se negativamente às práticas de incentivo à amamentação. A cesárea após trabalho de parto associou-se a maior risco de complicações maternas precoces e a disfunção sexual seis a oito meses pós-parto.
São Cristóvão, SE
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Tegerstedt, Gunilla. "Clinical and epidemiological aspects of pelvic floor dysfunction /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-065-6/.

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Zhang, Xiang Rong. "Mechanisms of antipsychotic-induced male sexual dysfunction." Thesis, Queen's University Belfast, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517534.

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Itkin, Natalie. "Treating Sexual Dysfunction in Orthodox Jewish Couples." Thesis, Alliant International University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=3624617.

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Sexual dysfunction is a major clinical and social issue. There has been a lack of research literature exploring the treatment implications involved in conducting sex therapy with Orthodox Jewish couples. Many standard sex therapy treatment interventions are incongruent with the religious beliefs held by Orthodox Jewish individuals regarding what they consider to be sexually appropriate practices. In order to increase the probability of Orthodox clients getting the treatment they need, it is crucial for mental health clinicians to demonstrate a high-level of understanding, awareness, and sensitivity toward their clients' religious beliefs. By fostering a sense of appreciation and understanding of Orthodox Jewish sexual practices, the clinician can then gain the ability to increase their clients' level of trust, safety, comfort, and willingness to participate in the treatment process. This doctoral project explored the issues surrounding the provision of sex therapy to Orthodox Jewish couples, and aimed to bridge the gap between the research literature and clinical practice. The purpose of this project was to increase the level of awareness of mental health professionals regarding how Orthodox Jewish religious beliefs influence views about sexuality, understand the treatment implications that arise during sex therapy with Orthodox couples, and methods of effectively modifying standard sex therapy interventions by incorporating Jewish laws into the therapeutic process. The author also incorporated a summary of the clinical findings obtained from interviews conducted with four expert field consultants who have worked with Orthodox Jewish couples in their practices.

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Creech, Linda Sue. "Urinary Incontinence and Sexual Intimacy: Older Women's Perceptions." Diss., Virginia Tech, 2002. http://hdl.handle.net/10919/27449.

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The purpose of this study was to examine factors that influence the experience of urinary incontinence (UI) as it relates to sexual intimacy for older women. Additionally, I wanted to identify perceived areas of intervention that might positively influence the experience of UI as it relates to sexual intimacy for participants. The sample consisted of 10 women who ranged in age from 65 to 81. The theoretical framework guiding this study was a systemic perspective in which how participants make meaning is given prominence. Symbolic interactionism, social constructionism, and systems perspective are interwoven to provide the foundation for this study. Data were collected utilizing in-depth interviews. Self-portraits were introduced to enrich conversation during the second interview. Three conclusions were drawn from this study. First, feelings of secrecy that permeated this project were manifested in the lack of willing participants as well as brevity of responses during interactions with participants. Second, participants indicated a tendency to minimize their incontinence and to manage their symptoms without formal medical intervention. Third, participants offered perceived potential interventions that might positively influence the experience of UI. These included the provision information related to UI in a way that does not require individuals to request the information, such as brochures at physicians' offices, post-surgical follow-up, and individuals from whom participants would be most comfortable receiving such information.
Ph. D.
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Braymam, Melanie. "Sexual Dysfunction: Providers’ Willingness to Ask LGBQ Veterans About their Sexual Functioning." Antioch University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1555249670122064.

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Mills, Ian W. "The pathophysiology of Detrusor instability and the role of bladder ischaemia in its aetiology." Thesis, University of Oxford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.325284.

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Sahay, Rashmi. "Female Sexual Dysfunction in women with Multiple Sclerosis." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1276947276.

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Cantor, James M. "Reversal of fluoxetine-induced sexual dysfunction in male rats." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/nq64531.pdf.

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Laycock, Josephine. "Assessment and treatment of pelvic floor dysfunction : physiotherapy in the management of pelvic floor dysfunction in relation to female urinary incontinence." Thesis, University of Bradford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316501.

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Owen, Suzzanne Jayne. "Female Rat Urinary Bladder and the Effects of Age, Diet and Ovariectomy." Thesis, Griffith University, 2011. http://hdl.handle.net/10072/367569.

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Bladder dysfunction, such as stress and urge incontinence, is experienced by both men and women, however it is more commonly reported in women. The female urogenital tract undergoes structural and functional change throughout life, whether in response to cyclic changes in reproductive hormones or progressive age-associated change. It is well recognised that the risk of developing bladder dysfunction and its severity increases in women in association with increasing age. To maintain continence, the bladder structure and function must have the capacity to respond to regulatory stimuli and retain the structural integrity of its tissue to permit the appropriate relaxation and contraction needed for voiding. Recently, in recognition of the potential to reduce menopausal symptomology, including urinary incontinence, increased intake of dietary phytoestrogens, as a potential source of oestrogen agonist activity has been reported to improve symptoms associated with bladder dysfunction. This study aimed to examine the effects of long term reduction of ovarian oestradiol on the structure and function of the urinary bladder and utilised the bilaterally ovariectomised female rat.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Griffith Health
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Yuen, Hang-yuk. "A study of sexual dysfunction in female breast cancer patients /." Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19470794.

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Bergmark, Karin. "Sexual dysfunction and other distressful symptoms in cervical cancer survivors /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-132-2.

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Yuen, Hang-yuk, and 袁亨玉. "A study of sexual dysfunction in female breast cancer patients." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31250336.

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Jha, Swati. "Urinary incontinence & impact of management on sexual function in women." Thesis, University of Sheffield, 2017. http://etheses.whiterose.ac.uk/18525/.

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Aims and Objectives: It was hypothesized that urinary incontinence has an impact on sexual function in women though the exact impact and its mechanism remains unproven. This thesis aimed to analyze the association between urinary incontinence and sexual function in women. The impact of different treatment modalities for urinary incontinence and their effect on sexual function was measured. This was through a series of separate experiments. Methods: It is widely accepted that urinary incontinence impacts on sexual function but the pathophysiology of sexual dysfunction remains unclear. A review of female sexual dysfunction (Paper 1) and the impact of pelvic floor problems on sexual function (Paper 2) was undertaken. As studies analyzing sexual function in women with pelvic floor disorders tend to cluster women with prolapse and incontinence it has been difficult to identify which of these has a greater impact on sexual function. A study was undertaken to compare sexual function in these 2 main disorders of the pelvic floor, prolapse and incontinence (Paper 3). The incidence of sexual dysfunction and comparison of symptoms in both groups were done using Mann-Whitney U test. The two most common causes for urinary incontinence are sphincter weakness and involuntary detrusor contractions, which usually manifest clinically as stress incontinence and overactive bladder. Traditional teaching has been that both are responsible for coital incontinence but there remains considerable controversy on the exact impact different types of urinary incontinence has. This was further explored in another study (Paper4). Data were collected as part of routine clinical care using an electronic pelvic floor questionnaire (ePAQ) and correlated with urodynamic findings. By correlating the different types of incontinence based on urodynamic diagnosis to sexual function, the exact incidence of coital incontinence, penetration and orgasm incontinence were estimated. Various treatment modalities for both types of urinary incontinence were assessed and the impact these treatments have on sexual function studied. The main treatments for Stress incontinence are Pelvic Floor Muscle Training (PFMT) and surgical treatment. To assess the former a prospective cohort randomized controlled trial was conducted looking at the impact of electrical stimulation compared to standard PFMT alone in women with urinary incontinence and the impact this has on sexual function (Paper 7). This was a single centre two arm parallel group randomised controlled trial. The interventions compared were electric stimulation versus standard pelvic floor muscle training. Outcome measures included Prolapse and Incontinence Sexual function Questionnaire (PISQ) physical function dimension at post-treatment (primary); other dimensions of PISQ, SF-36; EQ-5D, EPAQ, resource use, adverse events and cost-effectiveness (secondary outcomes). The impact of all continence surgery including the Tension free vaginal tape (TVT) on sexual function was evaluated by conducting a systematic review and meta-analysis (Paper 5). Observational studies and randomised controlled trials investigating the impact of surgical correction of stress urinary incontinence on sexual function were included. Surgical interventions included TVT, TVT-O, TOT, Burch and AFS. Studies which included patients undergoing concurrent prolapse surgery were excluded from the analysis. Coital incontinence was analyzed separately and OR with 95% CI calculated. The data were analysed in Review Manager 5 software. In addition to analyzing various treatment options we also compared the different types of midurethral tapes and their overall impact on sexual function. The mainstay of treatment for women with overactive bladder symptoms (OAB) is anticholinergics and this was assessed in a separate study. Women identified to have OAB and sexual dysfunction being commenced on anticholinergics were followed up to observe the impact of medical treatment on their sexual function (Paper 6). The ePAQ PF, PISQ 12 and PGI-I were used for the assessment of Overactive bladder and Sexual function. Sexually active women with overactive bladder were included in the study and assessed using the ePAQ-PF, PISQ 12 and PGI-I for Overactive bladder and Sexual function. Prolapse and voiding dysfunction were exclusion criteria for the study. All women were treatment naïve and followed up for 6 months. Sexual function before and after treatment was compared. The data were analysed using SPSS (version 20). Results: The individual impact of pelvic organ prolapse (POP) and urinary incontinence on sexual function was found to be similar. Patient and partner avoidance in women with POP was greater than those with stress urinary incontinence (Paper 3). Worsening urinary incontinence has a deleterious effect on sexual function. However the type of urinary incontinence as established on Urodynamic diagnosis does not correlate with the nature of underlying sexual problems, orgasm or penetration incontinence (Paper 4). PFMT improved sexual function, but there was no difference in the outcomes when comparing standard PFMT to electrical stimulation (Paper 7). Surgical correction of SUI significantly reduced coital incontinence . An analysis of overall impact on sexual function with all surgical continence procedures demonstrated an improvement, no change and deterioration in 31.9%, 55.5% and 13.1% respectively. These were similar when analyzing overall sexual function following mid urethral tapes in isolation (Paper 5). Anticholinergics and cure of overactive bladder did not however correlate to an improvement in sexual function (Paper 6). Conclusions: Sexual dysfunction is complex and multifactorial. The prevalence of sexual dysfunction is greater in women with pelvic floor disorders and the interventions for urinary incontinence have a variable impact.
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Nunes, Luciana Vargas Alves [UNIFESP]. "A acurácia da Escala de Experiência Sexual do Arizona (ASEX) para identificar disfunção sexual em pacientes do espectro da esquizofrenia." Universidade Federal de São Paulo (UNIFESP), 2009. http://repositorio.unifesp.br/handle/11600/8805.

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Made available in DSpace on 2015-07-22T20:49:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-02-27. Added 1 bitstream(s) on 2015-08-11T03:25:33Z : No. of bitstreams: 1 Publico-008.pdf: 1147299 bytes, checksum: c53fe718c40d4278be6155456942dfbe (MD5)
Contexto: a disfunção sexual é frequente entre pacientes com esquizofrenia, sendo relatada como um dos mais incômodos efeitos adversos dos antipsicóticos e esta diretamente relacionada com adesão ao tratamento. Objetivo: a) avaliar a frequência da disfunção sexual em uma amostra de pacientes do espectro da esquizofrenia em tratamento com antipsicóticos; b) investigar 0 efeito dos diferentes antipsicóticos na função sexual; e c) avaliar a acurácia da Escala de Experiência Sexual do Arizona (AS EX) para identificar disfunção sexual. Método: pacientes ambulatoriais com esquizofrenia ou transtorno esquizoafetivo foram entrevistados através de questionários: ASEX e Escala Dickson-Glazer (DGSFi) para avaliação do funcionamento sexual, em uma única entrevista. Resultados: 137 pacientes foram entrevistados. A sensibilidade e especificidade da ASEX em relação a DGSFi foram: 80.8% ( 95% IC= 70.0%-88.5%) e 88.1 % (95% IC=76.5%-94.7%), e a taxa de classificação incorreta foi 9.5%. A curva ROC comparando a pontuação da ASEX e DGSFi revelou valor de 0.93 (IC=0.879¬0.970) com 0 ponto de corte da ASEX encontrando sendo 14/15. A disfunção sexual foi mais alta entre as mulheres (79.2%) do que nos homens (33.3%) (X2=27.41, gl=1, p<0.001). Conclusão: pacientes em tratamento com antipsicóticos mostraram alta frequência de queixas sexuais e ASEX provou ser um instrumento eficaz para identificar disfunção sexual em amostra de pacientes ambulatoriais do espectro da esquizofrenia. Mulheres mostraram frequência mais alta de disfunção, e desejo sexual e habilidade para alcançar orgasmo foram áreas mais afetadas. 0 uso de antipsicóticos, principal mente 0 uso de combinações, foi associado com piora do funcionamento sexual..
Background: sexual dysfunction is frequent in patients with schizophrenia, it is reported as one of the most distressing antipsychotic’s adverse effects and it is directly related to treatment compliance. Objective: a) to assess the frequency of sexual dysfunction in a sample of outpatients with schizophrenia and schizoaffective disorder under antipsychotic therapy; b) to investigate the effect of different antipsychotics on sexual function; and c) to evaluate the accuracy of the Arizona Sexual Experience Scale (ASEX) to identify sexual dysfunction. Method: Outpatients with schizophrenia or schizoaffective disorder were asked to fulfill both the ASEX and the Dickson Glazer Scale for the Assessment of Sexual Functioning Inventory (DGSFi) at a single interview. Results: 137 patients were interwied. The sensitivity and specificity of the ASEX in relation to DGSFi were: 80.8%, (95% CI= 70.0%-88.5%) and 88.1% (95% CI= 76.5%-94.7%), and the misclassification rate was 9.5%. The ROC curve comparing the ASEX and the DGSFi scores revealed a value of 0.93 (CI= 0.879-0.970), with the optimum cut-off point of ASEX being 14/15. Sexual dysfunction measured was higher in females (79.2%) than in males (33.3%) (2 = 27.41, d.f.=1, p<0.001). Discussion: Patients under antipsychotic treatment showed a high level of sexual complaints, and the ASEX proved to be an accurate instrument to identify sexual dysfunction in an outpatient sample of patients with schizophrenia spectrum. Females showed a higher frequency of sexual dysfunctions and sexual drive and ability to reach orgasm were the most affected areas. The use of antipsychotics, especially the combinations, was more likely to impair sexual functioning.
TEDE
BV UNIFESP: Teses e dissertações
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Gonzalez, Eric James. "A Role For Transforming Growth Factor-Beta In Urinary Bladder Dysfunction With Cyclophosphamide-Induced Cystitis." ScholarWorks @ UVM, 2016. http://scholarworks.uvm.edu/graddis/553.

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Bladder pain syndrome (BPS)/interstitial cystitis (IC) is a chronic pain disorder characterized by at least six weeks of lower urinary tract symptoms and unpleasant sensations (pain, pressure and discomfort) thought to be related to the urinary bladder and not meeting exclusion criteria. While the etiology is not known, BPS/IC may involve a "vicious circle" of uroepithelial dysfunction, inflammation and peripheral and central sensitization. We propose that the urinary bladder inflammatory insult partly mediates voiding dysfunction and visceral neurogenic pain characteristic of BPS/IC. Several studies from our laboratory have already demonstrated the role(s) of cytokines and their downstream targets in the functional alterations in micturition reflex pathways following chemically (cyclophosphamide, CYP)-induced cystitis. More recently, the pleiotropic protein, TGF-β, has been implicated in the pathogenesis of CYP-induced cystitis. TGF-β is activated locally at the initial site of injury by protease-dependent or protease-independent mechanisms to initiate a proinflammatory milieu. Depending on its contextual cues, TGF-β may then aid in resolving the primary immune response and support tissue repair. Though TGF-β is necessary to maintain normal immunological function, its aberrant expression and activation may have detrimental effects on responding tissues and cell types. A sustained increase in peripheral TGF-β reactivity, such as what may be observed in chronic inflammatory bladder conditions, may influence bladder afferent excitability to amplify nociceptive transmission and CNS input. The subsequent sensitization of peripheral afferent nociceptors at the level of the DRG or urothelium may promote spinal cord "wind-up" and cascade into visceral hyperalgesia and allodynia. In the first aim of this dissertation we investigated the functional profile of TGF-β isoforms and receptor (TβR) variants in the normal and inflamed (CYP-induced cystitis) urinary bladder with qRT-PCR, ELISA, IHC and in vivo cystometry. Our studies determined (i) the involvement of TGF-β in lower urinary tract neuroplasticity following urinary bladder inflammation, (ii) a functional role for TGF-β signaling in the afferent limb of the micturition reflex and (iii) urinary bladder TβR-1 as a viable target to reduce voiding frequency with cystitis. In the second aim of this dissertation we investigated the sensory components of the urinary bladder that may underlie the pathophysiology of aberrant TGF-β activation with bladder-pelvic nerve electrophysiology and luciferin-luciferase assays for ATP measurement. Our studies determined that TGF-β1 increased bladder afferent nerve excitability by stimulating ATP release from the urothelium via vesicular exocytosis mechanisms with minimal contribution from pannexin-1 channels. Furthermore, blocking aberrant TGF-β signaling in CYP-induced cystitis with TβR-1 inhibition decreased afferent nerve excitability with an equivalent decrease in ATP release. Taken together, these results establish a causal link between an inflammatory mediator, TGF-β, and intrinsic signaling mechanisms of the urothelium that may contribute to the altered sensory processing of bladder filling to facilitate increased voiding frequency. The distinct interactions of multiple mediators underscore the challenges for single target therapies and support the development of combinatory therapeutics for bladder dysfunction. Ultimately, these studies have increased our understanding of functional disorders and visceral pain and have the potential to improve the health of those suffering from inflammation-associated bladder syndromes.
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Al-Momani, Muwafaq Mohammad. "Nurses' experience of caring for men with sexual dysfunction in Jordan." Thesis, University of Salford, 2011. http://usir.salford.ac.uk/26537/.

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Worldwide, sexual dysfunction is common among men regardless of age, ethnicity or cultural background therefore it is not unreasonable to assume such a problem exists within Jordan, despite the limited evidence available. This research examines the role of nurses in practice, nursing education and the impact of the Jordanian culture on the care of men with sexual dysfunction. The case study, using quantitative and qualitative mixed methods, questionnaires and semistructured interviews, explored in-depth the interplay of three key concepts: nurses' experiences, education and culture. Study instruments were translated, back-translated to establish semantic equivalence, then administered in Arabic or English (as preferred) to 462 nurses in the target population. Of these, 261 (58%) nurses completed the questionnaire, 17 of which agreed to take part in an interview. The findings identified that sexual health care and assessment for men was not an integral part of nursing practice with only 16 out of 261 nurses (6%) identifying having cared for and assessed the sexual health care needs of a male patient. Although, the majority of nurses (65%) recognised sexual health care was important for patients' health outcomes. Similar to other studies worldwide barriers to sexual health care included a lack of time to perform sexual health assessments due to a shortage of nurses and increased workload. However, both male and female nurses reported being openly discouraged by managers not to discuss sexual health with patients, even of the same sex, as this was culturally unacceptable. This was compounded by a medically dominated health profession, in which nurses identified a lack of autonomy to deliver sexual health care. Sexual dysfunction was perceived to be a hidden and unresolved problem within Jordan as a result of cultural and societal expectations, masculinity and perceived men's health beliefs, religious beliefs, lack of nursing confidentiality and trust. Only 30% of nurses felt equipped with the knowledge and skills to provide sexual health advice, with communication skills being identified as equally important. Nurses identified that gender based nursing education particularly for sensitive topics such as sexual health could definitely be delivered (either within the curriculum or through on-site specialist courses) to male and female nurses separately. The lack of sexual health care in nursing practice in Jordan could be an indicator of the low state of men's health services. In the context of improving men's sexual health a comprehensive strategy is necessary using education, awareness and developing appropriate gender sensitive health services congruent with the culture of Jordan.
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Beharry, Rochard Kelshall Sheldon. "Development and characterization of a rat model of female sexual dysfunction." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ63269.pdf.

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Smith, Ellen Kaye. "An Examination of the Relationship between Authenticity and Female Sexual Dysfunction." ScholarWorks, 2016. https://scholarworks.waldenu.edu/dissertations/2059.

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Since the late 1990s, researchers have reported a high degree of sexual dysfunction among American women that is associated with significant negative consequences (e.g., reduced quality of life and sexual satisfaction). In addition, sexual satisfaction is a primary factor in marital stability. Because of the widespread impact on both individual well-being and marital relationships, female sexual dysfunction is a significant public health problem. Most research has supported the predominance of psychocultural factors in women's sexual issues. Authenticity, defined by Kernis and Goldman as acting in accord with one's natural inclinations, is associated with increased well-being, but researchers have often overlooked it in the literature on female sexual dysfunction. This study, guided by Kernis and Goldman's authenticity theory, argued that gender culture impairs the ability of women to be authentic in the sexual realm, and, thereby, increases the risk of sexual problems. The purpose of this research study was to examine the relationship between authenticity, as measured by The Authenticity Inventory, Version 3, and female sexual dysfunction, as measured by The Female Sexual Function Index and The Female Sexual Distress Scale, Revised, in a group of 55 women attending an online university. The hypothesis was that women with higher rates of dysfunction and/or distress would score lower on authenticity. The results from a regression analysis did not reach significance and failed to confirm the hypothesis; however, there was an association between distress and dysfunction. This study contributes to social change by examining an association between authenticity and female sexual dysfunction that is of help to researchers and therapists working with women in the area of sexual health.
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Saotome, Tomoko. "Sexual Dysfunction and Satisfaction in Japanese Couples During Pregnancy and Postpartum." Kyoto University, 2019. http://hdl.handle.net/2433/242657.

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39

Uustal, Fornell Eva. "Pelvic floor dysfunction : a clinical and epidemiological study /." Linköping : Univ, 2003. http://www.bibl.liu.se/liupubl/disp/disp2003/med822s.pdf.

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40

Jacquet, Susan Ellen. "Sexual abuse experiences and family environment in childhood as predictors of sexual dysfunction and premarital relationships in adulthood /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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41

Prystowsky, Elya E. "Sexual intercourse, sexually transmitted infections, and urinary tract infections in post-menopausal women /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/10907.

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42

McClurg, Doreen Elizabeth. "Urinary dysfunction in multiple sclerosis : effect of pelvic floor muscle training, electromyography biofeedback and neuromuscular electrical stimulation." Thesis, University of Ulster, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433932.

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43

McCool, Megan Elizabeth [Verfasser], and Christian [Akademischer Betreuer] Apfelbacher. "Epidemiology and care of female sexual dysfunction / Megan Elizabeth McCool ; Betreuer: Christian Apfelbacher." Regensburg : Universitätsbibliothek Regensburg, 2017. http://d-nb.info/1126724602/34.

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44

Caselman, Gabrielle, Julia Dodd, Rebecca Altschuler, and Madison Hinkle. "Infertility’s Impact on Relationship Satisfaction: The Role of Sexual Dysfunction and Infertility Stigma." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7336.

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45

MaseTshaba, Musa. "Incomplete sex re-assignment surgery and psychosocial functioning : a preliminary study." Thesis, University of Limpopo (Medunsa Campus), 2010. http://hdl.handle.net/10386/873.

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46

Ho, Ming-sze Eugenie. "The nature and presentation of female sexual dysfunction in a group of Chinese diabetic population." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B24873135.

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47

何明詩 and Ming-sze Eugenie Ho. "The nature and presentation of female sexual dysfunction in a group ofChinese diabetic population." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31970564.

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48

Berry, M. D. "Towards a psychodynamically-informed model for the integrative psychotherapeutic treatment of male sexual dysfunction." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1463233/.

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Empirical research on sex therapy appears to be a significant and growing area in the social sciences, with researchers evaluating the use of a variety of different psychotherapy modalities in the treatment of male sexual problems. However, although clinical literature suggests that sex therapists may use psychodynamic techniques in their clinical practice, current empirical research on the place of psychodynamic methods in the sex therapy field is negligible. This research project aims to help fill this gap. The primary aim of this research project is to identify the role of psychodynamic methods in sex therapy. The principal research question underlying this work is: to what extent do psychosexual therapy specialists currently employ psychodynamic therapy techniques in treating men’s sexual dysfunctions? A number of secondary aims also guided this research programme. This work aimed to gather data on: • the ways in which sex therapists conceptualize and use the biopsychosocial model, • the diagnostic and assessment protocols they use with male clients, • the methods they use in establishing clinical goals and developing case formulations, • the ways in which sex therapy specialists conceive of and assess the aetiology of male sexual problems, and • the place that psychodynamic versus cognitive behavioural therapy (CBT) techniques play in the treatment of male sexual dysfunction. The role of psychodynamic theory and technique was considered in relation to all of these factors. Methods: To evaluate these issues, this research project used a combination of: 1) a questionnaire-based survey, administered to practitioners in the sex therapy field, and 2) interviews with sex therapists and subject matter experts. The questionnaire sample 6 consists of specialist sex therapists, and psychotherapy generalists who have experience in treating male sexual dysfunction. By examining the differences in technique reported by these two populations, this research sought to establish what is unique about psychosexual therapy, and what specific role psychodynamic techniques play within this specialization. The qualitative data generated from the interviews were used to clarify the integrative practices by which psychodynamically-based theory and technique are included in the treatment of male sexual dysfunction. Results: The data indicate that both sex therapists and psychotherapy generalists make use of prototypical and distinctive psychodynamic techniques to a significant degree in their work treating male sexual problems. Sex therapists report using psychodynamic and CBT techniques to approximately the same degree. Psychotherapy generalists report a higher level of adherence to psychodynamic techniques than sex therapists. Sex therapists report a high level of endorsement of the biopsychosocial model, and report drawing on a range of psychotherapy frameworks, including psychodynamic methods. A high level of focus on psychosocial and relational factors is reported, and attachment theory is identified as a key clinical factor in sex therapists’ work. The data suggest that sex therapists view insight—including insight into unconscious factors—as an important element of the therapeutic change process. Conclusions: The data indicate that psychodynamic theory and technique are integral to sex therapy practices. Often, however, psychodynamic techniques may be used implicitly and psychosexual therapists may not explicitly recognize their perspective as psychodynamic. Additionally, psychodynamically-informed techniques that focus on the client’s relationships, early life and development, and gaining insight into aetiology, may be of particular importance in the sex therapy field, and represent an area for future research.
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Gomez, John-Paul. "Critical Discourse Analysis of Sexual Enhancement Medication Ads." ScholarWorks@UNO, 2004. http://scholarworks.uno.edu/td/179.

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This study contributes to the expanding critical range of discourse analysis by analyzing texts used to market Viagra and other "sexual enhancement medication," pharmaceuticals that treat "erectile dysfunction". Applying elements of Norman Fairclough's critical discourse analysis framework, this study examines as cultural artifacts Viagra, Levitra, and Cialis print advertisements and television commercials and it offers insight into the institutional discourse of "sexual enhancement medication" and how this discourse constructs male identity and subjectivity.
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50

Mereckas, Gintautas. "Urinary incontinence, erectile dysfunctions and quality of life in elderly men of vilnius city." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20091228_152346-59989.

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Scientific adviser: Assoc. Prof. Dr. Vidmantas Alekna (Institute of Experimental and Clinical Medicine at Vilnius University, Biomedical sciences, Medicine - 07 B). The aim: To estimate the frequency of urinary incontinence (UI) in men residing in Vilnius city community and nursing institutions, to assess risk factors for UI, to determine the frequency of erectile dysfunction in men with UI, and to analyse their quality of life. Object and methods: 788 elderly men residing in Vilnius city community and 168 - in nursing institutions were interviewed. The respondents were interviewed with the specific and general questionnaires for UI and quality of life. Statistical data analysis was performed by applying SPSS 12.0 for Windows. Conclusions: Frequency of UI among the men living in Vilnius city community amounts to 17.8% and 38.1% - in nursing institutions. The benign prostatic hyperplasia, stroke, senile cognition disorder, Parkinson’s disease, depression, constipation and use of the some medications increase the risk of UI among elderly men. Erectile dysfunction was diagnosed in 79.2% of the men with UI aged 55 and over and in 36.7% of the healthy men of the same age. In men with UI the physical health, psychological state, social relations and the environment domains of quality of life were disturbed. After two years the quality of life of the men with UI became lower in the areas of physical health and social relations.
Mokslinis konsultantas: doc. dr. Vidmantas Alekna (Vilniaus universiteto Eksperimentinės ir klinikinės medicinos institutas, biomedicinos mokslai, medicina – 07 B). Darbo tikslas: ištirti Vilniaus mieste gyvenančių senyvo amžiaus vyrų šlapimo nelaikymo ir erekcijos sutrikimų ypatumus bei gyvenimo kokybę. Tyrimo objektas ir metodai. Tiriamųjų grupė sudaryta sluoksninės imties metodu. Apklausti 788 asmenys, gyvenantys Vilniaus m. bendruomenėje ir 168 vyrai – globos įstaigose. Respondentai buvo tiriami interviu metodu, naudojant specifinius ir bendrus klausimynus. Statistinė duomenų analizė atlikta „SPSS 12.0 for Windows“. Pagrindinės išvados. Šlapimo nelaikymo dažnumas tarp Vilniaus m. bendruomenėje gyvenančių 55 metų amžiaus ir vyresnių vyrų yra 17,8 proc., o tarp globos įstaigose gyvenančių vyrų – 38,1 proc. Su amžiumi šlapimo nelaikymo dažnumas didėja. Šlapimo nelaikymo riziką didina gerybinė prostatos hiperplazija, patirtas insultas, depresija, pažinimo sutrikimas, Parkinsono liga, obstipacija ir kai kurių vaistų vartojimas. Erekcijos sutrikimai nustatyti 79,2 proc. šlapimo nelaikančių 55 metų amžiaus ir vyresnių vyrų ir 36,7 proc. sveikų vyrų, gyvenančių Vilniaus m. bendruomenėje. Esant šlapimo nelaikymui yra blogesnės šios gyvenimo kokybės sritys: fizinė sveikata, psichologinė būsena, socialiniai santykiai ir aplinka. Po 2 metų gyvenimo kokybė pablogėjo fizinės sveikatos bei socialinių santykių srityse.
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