Journal articles: 'Upper digestive tract cancer'

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Reed, P. I. "Micronutrients and upper digestive tract cancer." European Journal of Cancer Prevention 6, no. 5 (October 1997): 494. http://dx.doi.org/10.1097/00008469-199710000-00037.

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M., PRABHAKARAN. "Upper Aero Digestive Tract Cancer: A Detailed Exploration Using Computer Vision Techniques." Journal of Research on the Lepidoptera 51, no. 2 (June 25, 2020): 648–65. http://dx.doi.org/10.36872/lepi/v51i2/301124.

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Turati, Federica, Marta Rossi, Claudio Pelucchi, Fabio Levi, and Carlo La Vecchia. "Fruit and vegetables and cancer risk: a review of southern European studies." British Journal of Nutrition 113, S2 (April 2015): S102—S110. http://dx.doi.org/10.1017/s0007114515000148.

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High intakes of fruit and vegetables may reduce the risk of cancer at several sites. Evidence has been derived mainly from case–control studies. We reviewed the relationship between consumption of vegetables and fruit and the risk of several common cancers in a network of Italian and Swiss case–control studies including over 10 000 cases of fourteen different cancers and about 17 000 controls. Data were suggestive of a protective role of vegetable intake on the risk of several common epithelial cancers. OR for the highest compared with the lowest levels of consumption ranged from 0·2 (larynx, oral cavity and pharynx) to 0·9 (prostate). Inverse associations were found for both raw and cooked vegetables, although for upper digestive tract cancers the former were somewhat stronger. Similar inverse associations were found for cruciferous vegetables. Frequent consumption of allium vegetables was also associated with reduced risk of several cancers. Fruit was a favourable correlate of the risk of several cancers, particularly of the upper digestive tract, with associations generally weaker than those reported for vegetables. A reduced risk of cancers of the digestive tract and larynx was found for high consumption of citrus fruit. Suggestive protections against several forms of cancer, mainly digestive tract cancers, were found for high consumption of apples and tomatoes. High intakes of fibres, flavonoids and proanthocyanidins were inversely related to various forms of cancer. In conclusion, data from our series of case–control studies suggested a favourable role of high intakes of fruit and vegetables in the risk of many common cancers, particularly of the digestive tract. This adds evidence to the indication that aspects of the Mediterranean diet may have a favourable impact not only on CVD, but also on several common (epithelial) cancers, particularly of the digestive tract.

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Bosetti, Cristina, Claudio Pelucchi, and Carlo La Vecchia. "Diet and cancer in Mediterranean countries: carbohydrates and fats." Public Health Nutrition 12, no. 9A (September 2009): 1595–600. http://dx.doi.org/10.1017/s1368980009990425.

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AbstractObjectiveSeveral aspects of the diet characteristic of the Mediterranean countries are considered favourable not only on cardiovascular disease, but also on cancer risk. We considered some aspects of the Mediterranean diet (including, in particular, the consumption of olive oil and carbohydrates) on cancer risk.Design, Setting and SubjectsData were derived from a series of case-control studies, conducted in Italy since the early 1990s, on over 10 000 cases of thirteen cancer sites and over 17 000 controls.ResultsOlive oil, and other mono- and unsaturated fats, appear to be favourable indicators of breast, ovarian, colorectal, but mostly of upper aero-digestive tract cancers. Whole grain foods are also related to reduced risk of upper aero-digestive tract and various other cancers. In contrast, refined grain intake and, consequently, glycaemic index and glycaemic load were associated to increased risk for several cancer sites. Fish, and hence a diet rich in n-3 polyunsaturated fatty acids, tended to be another favourable diet indicator, while frequent red meat intake was directly related to some common neoplasms. An a priori defined Mediterranean diet score was inversely related to upper digestive and respiratory tract cancers.ConclusionsThese data provide additional evidence that major characteristics of the Mediterranean diet favourably affect cancer risk.

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Song, Yinghao, Yulei Qu, Lu Li, Mengxuan Xing, Baohui Jia, Yingjie Ma, and Yong Zhang. "Application Value of the Diagnosis during Early Carcinoma of Upper Digestive Tract Based on Optical Enhanced Endoscopic Technique." Computational and Mathematical Methods in Medicine 2022 (July 19, 2022): 1–6. http://dx.doi.org/10.1155/2022/9587070.

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Objective. The diagnostic value of optical enhanced endoscopy in early cancer of upper digestive tract was studied by comparing the disease accuracy, tumor type, invasion, and various surgical indicators between the two groups. Methods. 188 patients with early upper gastrointestinal cancer treated in our hospital from January 2020 to February 2021 were selected as the research objects. The patients were randomly divided into the observation group and control group with 94 cases in each group. Results. The accuracy of early detection of early carcinoma of upper digestive tract in the observation group was 94.68% and that in the control group was 76.60%. The accuracy of the observation group was significantly higher than that in the control group, with statistical significance ( P < 0.05 ). In the observation group, 36 cases of early gastric cancer, 28 cases of early esophageal cancer, and 30 cases of early colorectal cancer were detected; 25 cases of early gastric cancer, 19 cases of early esophageal cancer, and 28 cases of early colorectal cancer were detected; 26 cases of early carcinoma of upper digestive tract infiltration were detected; and 68 cases were not detected, and the detection rate was 27.66%, which was higher than 9.57% in the control group, and the difference was statistically significant ( P < 0.05 ). After different methods of treatment, no death occurred in all patients. Except for the operation time, the surgical indexes of the observation group were better than the control group, the difference was statistically significant ( P < 0.05 ). Conclusion. Optical enhanced endoscopic technique had obvious effect in the diagnosis of patients with early cancer of upper digestive tract, it was helpful to improve the clinical detection rate of early carcinoma of upper digestive tract and had certain diagnostic ability for the invasion depth of early cancer of high upper gastrointestinal tract, which was conducive to the detection of clinical invasion lesions and had high clinical promotion and application value.

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Jiang, Xingyu, Qi Liang, Huanhuan Xu, Shouyong Gu, and Lingxiang Liu. "The Association of Waist Circumference with the Prevalence and Survival of Digestive Tract Cancer in US Adults: A Population Study Based on Machine Learning Methods." Computational and Mathematical Methods in Medicine 2022 (October 6, 2022): 1–11. http://dx.doi.org/10.1155/2022/2492488.

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Aims. This paper aims to investigate the relationship of waist circumference (WC) with digestive tract cancer morbidity and mortality. Methods. Based on the data from a nationally representative US population survey, we summarized the prevalence of digestive tract cancer and all-cause mortality of cancer patients across WC quartiles. Adjusted logistic regression and restricted spline curve were used to analyze WC and the prevalence of digestive tract cancer. Moreover, Cox regression and the Kaplan-Meier curve were applied to investigate the association of WC with all-cause mortality. We also attempted to make a model to predict cancer happening. Results. This paper included a total of 34,041 participants, with digestive tract cancer observed in 265 (0.7%) individuals. WC was positively associated with digestive tract cancer morbidity after full adjustment of covariates (OR: 1.72 and 95% CI: 1.41-2.10). Also, individuals in the highest WC group had a higher risk of digestive tract cancer (Q4, OR: 2.71 and 95% CI: 1.48-5.00). Moreover, no significant association was observed in upper digestive cancer, and WC was associated with a longer survival time once diagnosed (hazard ratio (HR): 0.50 and 95% CI: 0.28-0.92). Finally, the model we made proved to be effective. Conclusion. High WC is a risk factor for digestive tract cancer with or without adjusting for body mass index, especially those located in the lower digestive tract. However, once digestive tract cancer has been diagnosed, patients with higher WC showed better survival outcomes. Moreover, machine learning methods can be used to predict digestive tract cancer risk in the future.

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Gupta, Bhawna, Ratilal Lalloo, and Newell W. Johnson. "Life course models for upper aero-digestive tract cancer." International Dental Journal 65, no. 3 (June 2015): 111–19. http://dx.doi.org/10.1111/idj.12167.

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Vecchia, C. L., S. Franceschi, A. Favero, R. Talamini, E. Negri, K. K. Cheng, C. Cummins, et al. "Alcohol intake and cancer of the upper digestive tract." BMJ 318, no. 7193 (May 8, 1999): 1289. http://dx.doi.org/10.1136/bmj.318.7193.1289b.

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Farinati, F., R. Cardin, M. Zordan, F. Valiante, A. J. Garro, P. Burra, P. Venier, D. Nitti, A. G. Levis, and R. Naccarato. "Alcohol metabolism in the upper digestive tract." European Journal of Cancer Prevention 1 (October 1992): 25–32. http://dx.doi.org/10.1097/00008469-199210003-00004.

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Haguenoer, J. M., S. Cordier, C. Morel, J. L. Lefebvre, and D. Hemon. "Occupational risk factors for upper respiratory tract and upper digestive tract cancers." Occupational and Environmental Medicine 47, no. 6 (June 1, 1990): 380–83. http://dx.doi.org/10.1136/oem.47.6.380.

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La Vecchia, Carlo. "Mediterranean diet and cancer." Public Health Nutrition 7, no. 7 (October 2004): 965–68. http://dx.doi.org/10.1079/phn2004562.

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AbstractObjective:To analyse the role of various aspects of the Mediterranean diet in several common epithelial cancers, including digestive and selected non-digestive tract neoplasms.Design:Systematic analysis of data from a series of case-control studies.Setting:Northern Italy, between 1983 and 1998.Subjects:Over 12 000 cases of 20 cancer sites and 10 000 controls.Results:For most epithelial cancers, the risk decreased with increasing vegetable and fruit consumption, with relative risk (RR) between 0.3 and 0.7 for the highest versus the lowest tertile. For digestive tract cancers, population-attributable risks for low intake of vegetables and fruit ranged between 15 and 40%. A protective effect was observed also for breast, female genital tract, urinary tract and a few other epithelial neoplasms. A number of antioxidants and other micronutrients showed an inverse relationship with cancer risk, but the main components responsible for the favourable effect of a diet rich in vegetables and fruit remain undefined. Fish tended to be another favourable diet indicator. In contrast, subjects reporting frequent red meat intake showed RRs above unity for several common neoplasms. Intake of whole-grain foods was related to a reduced risk of several types of cancer, particularly of the upper digestive tract. This may be due to a favourable role of fibre, but the issue is still open to discussion. In contrast, refined grain intake and, consequently, glycaemic load and glycaemic index were associated with increased risk of different types of cancer including, among others, breast and colorectal.Conclusions:A low-risk diet for cancer in the Mediterranean would imply increasing the consumption of fruit and vegetables, as well as avoiding increasing the intakes of meat and refined carbohydrates. Further, olive oil and other unsaturated fats, which are also typical aspects of the Mediterranean diet, should be preferred to saturated ones.

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Vecchia, Carlo La, and Cristina Bosetti. "Diet and cancer risk in Mediterranean countries: open issues." Public Health Nutrition 9, no. 8A (December 2006): 1077–82. http://dx.doi.org/10.1017/s1368980007668475.

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AbstractObjectiveTo analyse various aspects of the Mediterranean diet in relation to the risk of several common cancers in Italy.DesignData from a series of case-control studies conducted in northern Italy between 1983 and 2004 on over 20 000 cases of several major cancers and 18 000 controls.ResultsFor most digestive tract cancers, the risk decreased with increasing vegetable and fruit consumption, with relative risks between 0.3 and 0.7 for the highest level of intake, and the population-attributable risks for low intake of vegetables and fruit ranged between 15 and 40%. Less strong inverse relations were observed for other (epithelial) cancers, too. A number of micronutrients contained in vegetables and fruit showed an inverse relation with cancer risk. In particular, flavones, flavonols and resveratrol were inversely related to breast cancer risk. Olive oil, which is a typical aspect of the Mediterranean diet, has also been inversely related to cancers of the colorectum and breast, and mainly of the upper digestive and respiratory tract. Consumption of pizza, one of the most typical Italian foods, was related to a reduced risk of digestive tract cancers, although pizza may simply be an aspecific indicator of the Italian diet.ConclusionsAdherence to the Mediterranean diet is a favourable indicator of the risk of several common epithelial cancers in Italy. A score summarising the major characteristics of the Mediterranean diet was related to a priori defined reduced risks of several digestive tract neoplasms by over 50%.

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Viarisio, Daniele, Karin Müller-Decker, Paola Zanna, Ulrich Kloz, Birgit Aengeneyndt, Rosita Accardi, Christa Flechtenmacher, Lutz Gissmann, and Massimo Tommasino. "Novel ß-HPV49 Transgenic Mouse Model of Upper Digestive Tract Cancer." Cancer Research 76, no. 14 (May 23, 2016): 4216–25. http://dx.doi.org/10.1158/0008-5472.can-16-0370.

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Thygesen, Lau C., Niels Keiding, Christoffer Johansen, and Morten Grønbæk. "Changes in alcohol intake and risk of upper digestive tract cancer." Acta Oncologica 46, no. 8 (January 2007): 1085–89. http://dx.doi.org/10.1080/02841860701441806.

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Seitz, Helmut K., and Patrick Meier. "The role of acetaldehyde in upper digestive tract cancer in alcoholics." Translational Research 149, no. 6 (June 2007): 293–97. http://dx.doi.org/10.1016/j.trsl.2006.12.002.

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Swoboda, H. "Shifts in respiratory and upper digestive tract cancer in Eastern Austria." European Journal of Cancer 29, no. 3 (January 1993): 479. http://dx.doi.org/10.1016/0959-8049(93)90412-9.

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Foma, Winga, Bathokedeou Amana, Essobozou Pegbessou, Haréfétéguéna Bissa, Saliou Adam, Warou Dolou, Tchin Darré, Essohanam Boko, and Eyawèlohn Kpemissi. "Upper aero digestive tract cancers: epidemiological and histopathological aspects in Togo." International Journal of Otorhinolaryngology and Head and Neck Surgery 3, no. 1 (December 28, 2016): 11. http://dx.doi.org/10.18203/issn.2454-5929.ijohns20164803.

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Background: The objective of the study was to describe the epidemiological and histopathological aspects of cancer of the upper aero digestive tract (UAT) in a reference service in Togo. Methods: It was a retrospective study about UAT cancers diagnosed in the ENT and maxillofacial surgery department of Sylvanus Olympio Teaching Hospital of Lomé in Togo from 1st January 2005 to 31 December 2014, or a period of 10 years. Results: The UAT cancers represented 0.3% of consultations and 64.8% of head and neck cancers. The average age of patients was 51.3 years (± 16.5) with extremes of 3 months and 86 years. The sex ratio was 1.77. Chronic smoking was found in 26.4% of patients with 1.6% of women; that of chronic alcoholism among 43.8% of which 7.7% of women and the simultaneous alcoolotabagisme in 20.9% of patients. The UAT cancers were dominated by cancers of the oral cavity (36.2%) with particularly a female predominance (53.2%), followed by the oropharynx (18.5%) and the larynx (18.1%). The squamous cell carcinoma was predominant in UAT cancers (83.5%) followed by non-Hodgkin lymphoma (8.9%) and adenocarcinoma (2.7%). Conclusions: UAT cancers are the largest contingent of head and neck cancers in Togo. They occur most often in men from the fifties but there are a high proportion of women. Histology is dominated by squamous cell carcinoma.

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Mathus-Vliegen, Elisabeth M. H., and Guido N. J. Tytgat. "Laser photocoagulation in the palliative treatment of upper digestive tract tumors." Cancer 57, no. 2 (January 15, 1986): 396–99. http://dx.doi.org/10.1002/1097-0142(19860115)57:2<396::aid-cncr2820570236>3.0.co;2-8.

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La Vecchia, C., C. Bosetti, E. Negri, F. Levi, and S. Franceschi. "Cigar Smoking and Cancers of the Upper Digestive Tract." JNCI Journal of the National Cancer Institute 90, no. 21 (November 4, 1998): 1670. http://dx.doi.org/10.1093/jnci/90.21.1670.

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Randi, Giorgia, Lorenza Scotti, Cristina Bosetti, Renato Talamini, Eva Negri, Fabio Levi, Silvia Franceschi, and Carlo La Vecchia. "Pipe smoking and cancers of the upper digestive tract." International Journal of Cancer 121, no. 9 (2007): 2049–51. http://dx.doi.org/10.1002/ijc.22791.

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Nakajima, Toshiyuki, Atsushi Nishiya, Touru Kakinuma, Ken-ichi Kosaka, Taiki Iwahori, Hiroshi Ohkune, Kenji Fujimori, et al. "Endoscopic Findings of the Upper Digestive Tract in Patients with Pancreatic Cancer." Progress of Digestive Endoscopy(1972) 47 (1995): 90–93. http://dx.doi.org/10.11641/pdensks.47.0_90.

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Jovanovic, Andreas, Ignaz G. H. van der Tol, Pieter J. Kostense, Engelbert A. J. M. Schulten, Nico de Vries, Gordon B. Snow, and Isaäc van der Waal. "Second respiratory and upper digestive tract cancer following oral squamous cell carcinoma." European Journal of Cancer Part B: Oral Oncology 30, no. 4 (July 1994): 225–29. http://dx.doi.org/10.1016/0964-1955(94)90001-9.

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Sersar, Sameh I., and Lamees A. Maghrabi. "Respiratory-digestive tract fistula: two-center retrospective observational study." Asian Cardiovascular and Thoracic Annals 26, no. 3 (February 2, 2018): 218–23. http://dx.doi.org/10.1177/0218492318755013.

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Background Aerodigestive fistulae can be defined as abnormal communications between the gastrointestinal tract and the respiratory tract. Choking after meals, coughing, feeding difficulties, tachycardia, and persistent pneumonia are the main presentations. The aim of our study was to review our experience in the management of 27 cases of acquired aerodigestive fistulae of different types, levels, and management. Methods We conducted a retrospective observational study on 27 cases of fistulae between the respiratory and digestive tracts, which were managed in 2 hospitals in Saudi Arabia in the last 5 years. The patients comprised 16 females and 11 males, with a mean age of 29 years (range 17–67 years). Results The most common aerodigestive tract fistula was tracheoesophageal in 8 patients, followed by esophagobronchial in 6, and esophagopleural in 5. Four postendoscopic fistulae were included. The least common were gastropleural and esophagopulmonary fistulae. The most common etiologies were iatrogenic and esophageal cancer, and the least common was blunt chest trauma. The main presentations were fever, chocking after or during meals, and tachycardia. We used various modalities of treatment: conservative, cervical repair, thoracoabdominal repair, hybrid insertion of a T-tube, endoscopic esophageal stenting, and endoscopic clipping of the fistulous tract. During follow-up, 6 patients died due to advanced esophageal cancer in 5 and upper airway obstruction after iatrogenic tracheobronchial fistula in one. Conclusion Acquired aerodigestive fistula is a devastating condition that should be managed early and aggressively by a multidisciplinary team.

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Anantharaman, Devasena, Tarik Gheit, Tim Waterboer, Behnoush Abedi-Ardekani, Christine Carreira, Sandrine McKay-Chopin, Valerie Gaborieau, et al. "Human Papillomavirus Infections and Upper Aero-Digestive Tract Cancers: The ARCAGE Study." JNCI: Journal of the National Cancer Institute 105, no. 8 (March 16, 2013): 536–45. http://dx.doi.org/10.1093/jnci/djt053.

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La Vecchia, Carlo, Ettore Bidoli, Salvatore Barra, Barbara D'Avanzo, Eva Negri, Renato Talamini, and Silvia Franceschi. "Type of cigarettes and cancers of the upper digestive and respiratory tract." Cancer Causes & Control 1, no. 1 (July 1990): 69–74. http://dx.doi.org/10.1007/bf00053185.

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Chien, Huei-Tzu, Chi-Chin Yeh, Chi-Kuang Young, Tzu-Ping Chen, Chun-Ta Liao, Hung-Ming Wang, Kai-Lun Cho, and Shiang-Fu Huang. "Polygenic Panels Predicting the Susceptibility of Multiple Upper Aerodigestive Tract Cancer in Oral Cancer Patients." Journal of Personalized Medicine 11, no. 5 (May 18, 2021): 425. http://dx.doi.org/10.3390/jpm11050425.

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Head and neck cancer was closely related with habitual use of cigarette and alcohol. Those cancer patients are susceptible to develop multiple primary tumors (MPTs). In this study, we utilized the single nucleotide polymorphisms (SNPs) array (Affymetrix Axion Genome-Wide TWB 2.0 Array Plate) to investigate patients’ risks of developing multiple primary cancers. We recruited 712 male head and neck cancer patients between Mar 1996 and Feb 2017. Two hundred and eighty-six patients (40.2%) had MPTs and 426 (59.8%) had single cancer. Four hundred and twelve normal controls were also recruited. A list of seventeen factors was extracted and ten factors were demonstrated to increase the risks of multiple primary cancers (alcohol drinking, rs118169127, rs149089400, rs76367287, rs61401220, rs141057871, rs7129229, older age, rs3760265, rs9554264; all were p value < 0.05). Polygenic scoring model was built and the area under curve to predict the risk developing MPTs is 0.906. Alcohol drinking, among the seventeen factors, was the most important risk factor to develop MPT in upper aerodigestive tract (OR: 7.071, 95% C.I.: 2.134–23.434). For those with high score in polygenic model, routine screening of upper digestive tract including laryngoscope and esophagoscope is suggested to detect new primaries early.

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Bosetti, C., S. Franceschi, E. Negri, R. Talamini, F. Tomei, and C. La Vecchia. "Changing socioeconomic correlates for cancers of the upper digestive tract." Annals of Oncology 12, no. 3 (March 2001): 327–30. http://dx.doi.org/10.1023/a:1011180524985.

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Izzo, J. G., W. N. Hittelman, D. D. Liu, J. J. Lee, X. Wu, W. K. Hong, and V. A. Papadimitrakopoulou. "Cyclin D1 polymorphism, biochemoprevention and risk of upper aero-digestive tract cancer development." Journal of Clinical Oncology 22, no. 14_suppl (July 15, 2004): 1006. http://dx.doi.org/10.1200/jco.2004.22.14_suppl.1006.

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Lee, Duk-Hee, Kristin E. Anderson, Aaron R. Folsom, and David R. Jacobs. "Heme iron, zinc and upper digestive tract cancer: The Iowa Women's Health Study." International Journal of Cancer 117, no. 4 (2005): 643–47. http://dx.doi.org/10.1002/ijc.21215.

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Izzo, J. G., W. N. Hittelman, D. D. Liu, J. J. Lee, X. Wu, W. K. Hong, and V. A. Papadimitrakopoulou. "Cyclin D1 polymorphism, biochemoprevention and risk of upper aero-digestive tract cancer development." Journal of Clinical Oncology 22, no. 14_suppl (July 15, 2004): 1006. http://dx.doi.org/10.1200/jco.2004.22.90140.1006.

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Snijders, P. "Role of human papillomaviruses in cancer of the respiratory and upper digestive tract." Clinics in Dermatology 15, no. 3 (June 1997): 415–25. http://dx.doi.org/10.1016/s0738-081x(96)00156-3.

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Leclerc, Annette, Jacques Brugère, Danièle Luce, Dominique Point, and Pascal Guenel. "Type of alcoholic beverage and cancer of the upper respiratory and digestive tract." European Journal of Cancer and Clinical Oncology 23, no. 5 (May 1987): 529–34. http://dx.doi.org/10.1016/0277-5379(87)90315-4.

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Yuan, Xiang, Yiwen Liu, Jinyu Kong, Bianli Gu, Yijun Qi, Xinshuai Wang, Man Sun, et al. "Different frequencies of Porphyromonas gingivalis infection in cancers of the upper digestive tract." Cancer Letters 404 (September 2017): 1–7. http://dx.doi.org/10.1016/j.canlet.2017.07.003.

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Hoc, Tran Hieu, Nguyen Duy Hieu, Pham Van Phu, Tran Thu Huong, and Tran Que Son. "Nutritional status of patients undergoing upper gastrointestinal cancer surgery: A cross-sectional study at a single centre." Tạp chí Nghiên cứu Y học 148, no. 12 (December 31, 2021): 158–64. http://dx.doi.org/10.52852/tcncyh.v148i12.565.

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Malnutrition is closely related to the outcome of disease treatment, especially in digestive cancer surgery. The aim of this study was to assess the nutritional condition of pre-operative patients with upper digestive cancers (including stomach and oesophagus) at the Department of General Surgery, Bach Mai Hospital in 2016. We conducted a cross-sectional descriptive analysis of 76 malignancies of the upper gastrointestinal tract with surgical treatments. The results revealed that the weight loss rate of hospitalized patients with gastric cancer and esophageal cancer was 76.6% and 66.7%, respectively. The rate of weight loss above 10% of body weight was 19.7%. The prevalence of chronic energy deficit was 29.9%. The risk of malnutrition according to SGA was 77.6%, of which mild to moderate and severe was 67.2% and 10.4%, respectively. The rate of low blood albumin level (less than 35 g/L) was 36.5%. The average net nutritional value was 1146.3 ± 592.7 Kcal (range 246.7 – 3653.5), which equals to 55.7% of the necessary daily intake. Protein, lipid, and glucid contents reached 73.4%, 57.8%, and 52.1% of the recommended levels, respectively. Conclusion: malnutrition was still prevalent among patients undergoing upper gastrointestinal cancer surgery, and pre-operative nutritional status does not achieve recommended levels.

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Nakama, Hidenori, Noboru Kamijo, Kazuya Fujimori, A. S. M. Abdul Fattah, and Bing Zhang. "Diagnostic Accuracy of Immunochemical Faecal Occult Blood Test for Gastric Cancer." Journal of Medical Screening 3, no. 3 (September 1996): 113–14. http://dx.doi.org/10.1177/096914139600300301.

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Objectives –Toinvestigate the accuracy of the immunochemical occult blood test in screening for gastric cancer and to evaluate whether or not the upper digestive tract should be examined when the occult blood test is positive but there is no abnormal sign in the colorectum. Methods –In a case-control study an occult blood test was carried out on 150 subjects with gastric cancer, ISO subjects with colorectal cancer, and on 300 healthy subjects. Data were analysed from 44 996 persons attending a population screening programme who underwent both radiological gastric cancer screening (barium meal) and colorectal cancer examination by occult blood test. Results –In the case—control study the occult blood test was positive in 27/150 (18%) subjects with gastric cancer, in 112/150 (75%) subjects with colorectal cancer, and in 24/300 (8%) healthy controls. In the population screening programme the occult blood test was positive in 4/50 (8%) persons with gastric cancer and 3232/44 950 (7%) persons without gastric cancer,- indicating no difference between them. Conclusions –These data show that the immunochemical faecal occult blood test is worthless as a screening test for gastric cancer, and that examination of the upper digestive tract is unnecessary in cases where the faecal occult blood test is positive but there is no sign of colorectal disease.

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Razvodovsky, Y. "Suicides and Cancer Mortality in Russia: A Comparative Analysis of Trends." European Psychiatry 41, S1 (April 2017): S253. http://dx.doi.org/10.1016/j.eurpsy.2017.02.044.

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IntroductionThe association between suicide and cancer is complex. Hopelessness and depression are the common risk factors for both suicide and cancer. There is also evidence that suicide rate in cancer patients are higher than in the general population. However, the real occurrence of suicide in cancer patients is considered to be underreported. This is a good reason to expect a positive relationship between cancer mortality and suicide rates at the population level.AimsThe present study aims to test the hypothesis of the close aggregate level link between cancer mortality and the suicide rates in Russia.MethodsTrends in sex-specific cancer mortality and the suicide rates from 1956 to 2010 were analyzed employing a distributed lags analysis.ResultsThe results of analysis indicate the presence of a statistically significant association between trends in suicides and cancer of the upper digestive tract (mouth, oral cavity and pharynx), larynx, bronchus and lungs, stomach, colorectal, uretus and leukemia for male. There is also a statistically significant association between trends in suicides and cancer of the upper digestive tract (mouth, oral cavity and pharynx), larynx, bronchus and lungs, stomach, colorectal, uretus, breast, cervix, uterus and leukemia for female.ConclusionsCommon confounding variables, including binge drinking and psychosocial distress, may explain positive aggregate-level association between the cancer mortality and suicides time series in Russia.Disclosure of interestThe author has not supplied his/her declaration of competing interest.

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QI, Xiaopeng, Wei JI, Hongyan REN, Yan GUO, Maigeng ZHOU, Gonghuan YANG, and Dafang ZHUANG. "Model Analysis of Upper Digestive Tract Cancer and Environmental Pollution in Huaihe River Watershed." Geo-information Science 14, no. 4 (November 27, 2012): 432–41. http://dx.doi.org/10.3724/sp.j.1047.2012.00432.

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韩, 敬军. "Research Progress in Early Diagnosis and Early Treatment of Upper Digestive Tract Cancer Screening." Advances in Clinical Medicine 12, no. 09 (2022): 8365–70. http://dx.doi.org/10.12677/acm.2022.1291206.

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Aminianfar, Azadeh, Roohallah Fallah-Moshkani, Asma Salari-Moghaddam, Parvane Saneei, Bagher Larijani, and Ahmad Esmaillzadeh. "Egg Consumption and Risk of Upper Aero-Digestive Tract Cancers: A Systematic Review and Meta-Analysis of Observational Studies." Advances in Nutrition 10, no. 4 (April 30, 2019): 660–72. http://dx.doi.org/10.1093/advances/nmz010.

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ABSTRACT Limited data are available that summarize the relation between egg intake and the risk of upper aero-digestive tract (UADT) cancers. This systematic review and meta-analysis was conducted to investigate the association between egg intake and the risk of UADT cancers. Medline/PubMed, ISI web of knowledge, EMBASE, Scopus, and Google Scholar were searched using relevant keywords. Observational studies conducted on humans investigating the association between egg consumption and the risk of UADT cancers were included. Overall, 38 studies with a total of 164,241 subjects (27, 025 cases) were included. Based on 40 effect sizes from 32 case-control studies, we found a 42% increased risk of UADT cancers among those with the highest egg consumption (ranging from ≥1 meal/d to ≥1 time/mo among studies) compared to those with the lowest intake (ranging from 0–20 g/d to never consumed among studies) (overall OR: 1.42; 95% CI: 1.19, 1.68; P < 0.001). However, this association was only evident in hospital-based case-control (HCC) studies (OR = 1.50; 95% CI: 1.34, 1.68; P < 0.001 for ‘oropharyngeal and laryngeal cancer’ and OR: 1.27; 95% CI: 1.08, 1.50; P = 0.004 for esophageal cancer) and not in population-based case-control (PCC) studies (OR = 1.25; 95% CI: 0.59, 2.67; P = 0.56 for ‘oropharyngeal and laryngeal cancer’ and OR: 1.29; 95% CI: 0.92, 1.81; P = 0.13 for esophageal cancer). In addition, the association was not significant in prospective cohort studies (overall OR: 0.86; 95% CI: 0.71, 1.04; P = 0.11). Considering individual cancers, a positive association was observed between the highest egg consumption, compared with the lowest, and risk of oropharyngeal (OR: 1.88; 95% CI: 1.61, 2.20; P < 0.001), laryngeal (OR: 1.83; 95% CI: 1.45, 2.32; P < 0.001), oral & pharyngeal & laryngeal (OR: 1.37; 95% CI: 1.12, 1.67; P < 0.001), and esophageal cancers (OR: 1.28; 95% CI: 1.10,1.48; P = 0.001). We also found an inverse association between egg intake and the risk of oral cancer (OR: 0.78; 95% CI: 0.62, 0.99; P = 0.04). In conclusion, high egg consumption (ranging from ≥1 meal/d to ≥1 time/mo among studies) was associated with increased risk of UADT cancers only in HCC studies but not in PCC or prospective cohort studies. PROSPERO registration number: CRD42018102619.

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Yang, Ying, Rita V. Burke, Christie Y. Jeon, Shen-Chih Chang, Po-Yin Chang, Hal Morgenstern, Donald P. Tashkin, et al. "Polymorphisms of peroxisome proliferator-activated receptors and survival of lung cancer and upper aero-digestive tract cancers." Lung Cancer 85, no. 3 (September 2014): 449–56. http://dx.doi.org/10.1016/j.lungcan.2014.06.014.

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Salahudeen, Ameen Abdulla, Xingnan Li, Michael Cantrell, and Calvin Jay Kuo. "Gastrointestinal organoid cultures for functional evaluation of oncogenic loci." Journal of Clinical Oncology 33, no. 3_suppl (January 20, 2015): 85. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.85.

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85 Background: Novel in vitro methods surpassing limitations of current gastrointestinal cancer models such as gastric and esophagus cancer are required to functionally validate putative oncogenic loci discovered by genome sequencing efforts. The in vitro culture of primary, non-transformed tissues as three-dimensional organoids that accurately recapitulate organ structure and physiology has diverse applications including cancer biology. Methods: Mouse wild type, or p53flox/flox in tandem with lox-stop-lox KRASG12D upper digestive tract tissue containing epithelial and mesenchymal components were cultured in an air-liquid-interface and subjected to adenovirus expressing either immunoglobulin Fc (control) or GFP tagged Cre recombinase. Results: 3-dimensional organoids were generated with histological adherence to normal tissue architecture including that seen in esophagus and were able to be maintained in long term culture. Organoids exposed to GFP tagged Cre adenovirus demonstrated green fluorescence not seen in organoids exposed to control virus. Conditional allele organoids that were exposed to Cre adenovirus demonstrated increased rate of growth compared to controls. Histology of these rapidly growing organoids demonstrated cellular features consistent with dysplasia. Conclusions: 3-dimensional organoids can be generated from upper digestive tract tissues, can undergo adenoviral mediated transfection to achieve oncogenic gene expression or inactivation resulting in dysplastic morphology. 3-dimensional organoids are therefore an attractive model to study or identify candidate oncogenic loci identified by recent genomic sequencing studies.

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Vecchia, Carlo La. "Tomatoes, Lycopene Intake, and Digestive Tract and Female Hormone-Related Neoplasms." Experimental Biology and Medicine 227, no. 10 (November 2002): 860–63. http://dx.doi.org/10.1177/153537020222701004.

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Tomato consumption showed a consistent inverse relation with the risk of digestive tract neoplasms in Italy in an integrated series of studies conducted in the 1980s. Another series of case-control studies was conducted between 1992 and 1999 in different areas of Italy. Cases were patients below age 80 with incident, histologically confirmed cancer of the oral cavity and pharynx (n = 754), esophagus (n = 304), colorectum (n = 1953), breast (n = 2529), and ovary (n = 1031). The comparison group involved, overall, over 5000 patients below age 80 with acute, non-neoplastic, nonhormone-related diseases, unrelated to long-term diet modifications and admitted to the same network of hospitals. Information was collected in hospital by trained interviewers using a validated food frequency questionnaire, including 78 foods or groups of foods, various alcoholic beverage, and fat-intake pattern. The multivariate relative risk (RR) of oral, pharyngeal, and esophageal cancer decreased across subsequent levels of lycopene intake to reach 0.7 (95% confidence interval [CI] 0.4–1.0) for oral and pharyngeal, and 0.7 (95% CI 0.4–1.1) for esophageal cancer in the highest quintile of intake. Both trends in risk were of borderline statistical significance. With reference to colorectal, breast, and ovarian cancer, although no consistent association was observed for lycopene (RR = 1.0 for colorectal, 1.2 for breast, and 1.1 for ovary in the highest quintile), tomato Intake was inversely and significantly related with colorectal cancer (RR = 0.8). The inverse relation between lycopene and upper digestive tract neoplasms was not explained by alcohol or tobacco, sociodemographic factors, or total energy Intake. The interpretation of such an inverse relation, however, remains open to discussion because it may be related to an effect of lycopene due to its antioxidant effect and/or a potential role of lycopene in decreasing Insulin growth factor I, which is a promoter in the process of carcinogenesis.

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Koshiaris, C., P. Aveyard, J. Oke, R. Ryan, L. Szatkowski, R. Stevens, and A. Farley. "Smoking cessation and survival in lung, upper aero-digestive tract and bladder cancer: cohort study." British Journal of Cancer 117, no. 8 (September 12, 2017): 1224–32. http://dx.doi.org/10.1038/bjc.2017.179.

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Yu, Guoqin, Mitchell H. Gail, Jianxin Shi, Vanja Klepac-Ceraj, Bruce J. Paster, Bruce A. Dye, Guo-Qing Wang, et al. "Association between Upper Digestive Tract Microbiota and Cancer-Predisposing States in the Esophagus and Stomach." Cancer Epidemiology Biomarkers & Prevention 23, no. 5 (April 3, 2014): 735–41. http://dx.doi.org/10.1158/1055-9965.epi-13-0855.

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Oyama, Kunihiro, Takamasa Onuki, Masahiro Mae, Takashi Adachi, Masato Kanzaki, Masahide Murasugi, Yasuyuki Sone, Jun-ichi Kei, Masayoshi Yokoyama, and Sumio Nitta. "Combined thoracic aortic or upper digestive tract resection for lung cancer and malignant mediastinal tumor." Japanese Journal of Thoracic and Cardiovascular Surgery 48, no. 1 (January 2000): 9–15. http://dx.doi.org/10.1007/bf03218079.

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Dal Maso, Luigino, Carlo La Vecchia, Jerry Polesel, Renato Talamini, Fabio Levi, Ettore Conti, Paola Zambon, Eva Negri, and Silvia Franceschi. "Alcohol drinking outside meals and cancers of the upper aero-digestive tract." International Journal of Cancer 102, no. 4 (October 24, 2002): 435–37. http://dx.doi.org/10.1002/ijc.10723.

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Guenel, Pascal, Henrik Møller, and Elsebeth Lynge. "Incidence of the Upper Respiratory and Digestive Tract Cancers and Consumption of Alcohol and Tobacco in Denmark." Scandinavian Journal of Social Medicine 16, no. 4 (December 1988): 257–63. http://dx.doi.org/10.1177/140349488801600413.

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To study the incidence of upper respiratory and digestive tract cancer in Denmark in relation to changes in tobacco and alcohol consumption, the incidence trends are compared to the figures for average annual consumption during the period 1943–1982. The comparison is made using relative risk estimates available from previous investigations. From the available data on alcohol and tobacco consumption, an attempt is also made to predict the future incidence trends of these cancers. Since no data on the distribution of smoking versus drinking by sex and age are available from Denmark over the study period, two hypotheses are used. It is shown that the predicted incidence is strongly dependent on the distribution of smoking and drinking, and that the existence of a group with heavy consumption of tobacco and alcohol could be responsible for very high incidences of these cancers in the near future in Denmark.

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Tandon, D. A., S. Bahadur, H. C. Laldina, and K. R. Sundaram. "Role of prophylactic antibiotics in surgery for advanced head and neck cancer." Journal of Laryngology & Otology 106, no. 7 (July 1992): 621–24. http://dx.doi.org/10.1017/s0022215100120353.

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AbstractFour regimens of prophylactic antibiotics were utilized in 122 consecutive patients of stages III and IV carcinoma of the upper aero-digestive tract undergoing major resections in a randomized single-blind study. Ampicillin, gentamicin, cephalexin and metronidazole were used in different combinations for periods of 5 or 10 days. A cephalexin-metronidazole protocol for 10 days was associated with lowest post-operative infection rate. Oral-oropharyngeal resection and use of pectoralis major myocutaneous flap were the most important factors contributing to infection.

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Girard, Nicolas, Cristi Marin, Zofia Hélias‐Rodzewicz, Chiara Villa, Catherine Julié, Anne‐Sophie Lajarte‐Thirouard, Simon Martin Beauce, et al. "CARMN‐NOTCH2 fusion transcript drives high NOTCH2 expression in glomus tumors of the upper digestive tract." Genes, Chromosomes and Cancer 60, no. 11 (July 21, 2021): 723–32. http://dx.doi.org/10.1002/gcc.22981.

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Vulpoi, Radu-Alexandru, Mihaela Luca, Adrian Ciobanu, Andrei Olteanu, Oana-Bogdana Barboi, and Vasile Liviu Drug. "Artificial Intelligence in Digestive Endoscopy—Where Are We and Where Are We Going?" Diagnostics 12, no. 4 (April 8, 2022): 927. http://dx.doi.org/10.3390/diagnostics12040927.

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Artificial intelligence, a computer-based concept that tries to mimic human thinking, is slowly becoming part of the endoscopy lab. It has developed considerably since the first attempt at developing an automated medical diagnostic tool, today being adopted in almost all medical fields, digestive endoscopy included. The detection rate of preneoplastic lesions (i.e., polyps) during colonoscopy may be increased with artificial intelligence assistance. It has also proven useful in detecting signs of ulcerative colitis activity. In upper digestive endoscopy, deep learning models may prove to be useful in the diagnosis and management of upper digestive tract diseases, such as gastroesophageal reflux disease, Barrett’s esophagus, and gastric cancer. As is the case with all new medical devices, there are challenges in the implementation in daily medical practice. The regulatory, economic, organizational culture, and language barriers between humans and machines are a few of them. Even so, many devices have been approved for use by their respective regulators. Future studies are currently striving to develop deep learning models that can replicate a growing amount of human brain activity. In conclusion, artificial intelligence may become an indispensable tool in digestive endoscopy.

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Journal articles on the topic 'Upper digestive tract cancer'

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