Relevant bibliographies by topics / UPLC-DAD-MSn

Academic literature on the topic 'UPLC-DAD-MSn'

Author: Grafiati
Published: 7 July 2024
Last updated: 7 July 2024

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Contents

  1. Journal articles
  2. Dissertations / Theses

Journal articles on the topic "UPLC-DAD-MSn":

1

Fu, Yu, Ruiqin Sun, Jingfan Yang, Lili Wang, Peng Zhao, and Suiqing Chen. "Characterization and Quantification of Phenolic Constituents in Peach Blossom by UPLC-LTQ-Orbitrap-MS and UPLC-DAD." Natural Product Communications 15, no. 1 (January 2020): 1934578X1988443. http://dx.doi.org/10.1177/1934578x19884437.

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Peach blossom comes from the flower of Prunus persica (L.) Batsch, which is used as herbal tea and medicine in China and Korea. It could promote defecation and alleviate the abdominal pain. In this paper, the methods, ultra-performance liquid chromatography (UPLC) method coupled with electrospray ionization hybrid linear trap quadrupole orbitrap mass spectrometry (LTQ OrbitrapMS) and UPLC system coupled with a diode array detector (DAD), were developed for the qualitative and quantitative analysis of the flavonoids and phenolic acids in peach blossoms. Eight standards were divided into 3 types according to their basic skeletons: phenolic acids, quercetin-type flavonoids, and kaempferol-type flavonoids. The MSn fragmentation behaviors and diagnostic ions of these 3 types of compounds were proposed to aid the structural identification of components in peach blossom extract. By extracting the diagnostic ions from the mass spectrum in negative mode, a total of 25 compounds, including 8 phenolic acids and 17 flavonoids, were screened out. Among these compounds, 5 compounds (chlorogenic acid, ferulic acid, rutin, hyperoside, and isoquercetrin) were quantitated by UPLC-DAD. The linearity, precision, accuracy, limit of detection, and limit of quantitation were validated for the quantification method. The validated method was applied to assay 9 batches of peach blossoms from different regions. This study was the first report on the systematic qualitative analysis of compounds in peach blossom, providing insights into the quality control of peach blossom.
2

Wu, Lingfang, Qiunan Zhang, Wenyi Liang, Yongben Ma, Liying Niu, and Lanzhen Zhang. "Phytochemical Analysis Using UPLC-MSn Combined with Network Pharmacology Approaches to Explore the Biomarkers for the Quality Control of the Anticancer Tannin Fraction of Phyllanthus emblica L. Habitat in Nepal." Evidence-Based Complementary and Alternative Medicine 2021 (March 25, 2021): 1–19. http://dx.doi.org/10.1155/2021/6623791.

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Phyllanthus emblica L. is widely used in traditional Tibetan medicine for its therapeutic effects on treating liver, kidney, and bladder problems. We have reported that the tannin fraction has a good anti-hepatocellular carcinoma effect, but its active ingredients are not clear. This study was to find the active ingredients of the tannin fraction using UPLC-MSn and network pharmacology. First of all, the UPLC-MSn method was employed to obtain high-resolution mass spectra of different components, and 110 compounds were obtained. Then a network pharmacology method was used to find biomarkers for quality control. Network pharmacology results showed that gallic acid, punicalagin A, punicalagin B, methyl gallate, geraniin, corilagin, chebulinic acid, chebulagic acid, and ellagic acid should be the biomarkers of the tannin fraction. Furthermore, 9 components were detected in the serum, which also proved that they could be biomarkers, because we generally believe that the ingredients which are absorbed into the blood are effective. In the end, a simple method for simultaneously determining the contents of the 9 compounds was constructed by HPLC-DAD. This research established a new method to find biomarkers of traditional Chinese medicine. This is of great significance to improving the quality standards of Tibetan medicine.
3

Vallverdú-Queralt, Anna, Emmanuelle Meudec, Nayla Ferreira-Lima, Nicolas Sommerer, Olivier Dangles, Véronique Cheynier, and Christine Le Guernevé. "A comprehensive investigation of guaiacyl-pyranoanthocyanin synthesis by one-/two-dimensional NMR and UPLC–DAD–ESI–MSn." Food Chemistry 199 (May 2016): 902–10. http://dx.doi.org/10.1016/j.foodchem.2015.12.089.

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4

Haddouchi, Farah, Tarik Mohammed Chaouche, Riadh Ksouri, and Romain Larbat. "Leafy Stems of Phagnalon saxatile subsp. saxatile from Algeriaas a Source of Chlorogenic Acids and Flavonoids with Antioxidant Activity: Characterization and Quantification Using UPLC-DAD-ESI-MSn." Metabolites 11, no. 5 (April 29, 2021): 280. http://dx.doi.org/10.3390/metabo11050280.

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Phagnalon saxatile subsp. saxatile is a wild species widespread in Algeria which is utilized for medicinal purposes as analgesic and anticholesterolemic. However, information is still scarce regarding its phytochemical content. The objective of this study was to identify and quantify the phenolic compounds from different extracts of its leafy stems. For this purpose, the effects of four extracting solvents were investigated on the content of phenolic compounds and the antioxidant activity of this plant. The extracts prepared with polar solvents (methanol and water) contained higher amounts of phenolic compounds and showed better antioxidant activity than the extracts with apolar solvents (hexane, dichloromethane). The methanolic extract, richest in total phenolic and total flavonoid, had significant antioxidant activity as regarded by DPPH° scavenging capacity (IC50 of 5.5 µg/mL), ABTS+° scavenging capacity (IC50 of 63.8 µg/mL) and inhibition of oxidation of linoleic acid (IC50 of 22.7 µg/mL), when compared to synthetic antioxidants. Chlorogenic acids and several flavonoids were identified and quantified by UPLC-DAD-MSn. The di-O-caffeoylquinic acids isomers were the most concentrated phenolics (25.4 mg/g DW) in the methanolic extract.
5

Patient, Arnaud, Elodie Jean-Marie, Jean-Charles Robinson, Karine Martial, Emmanuelle Meudec, Joëlle Levalois-Grützmacher, Brigitte Closs, and Didier Bereau. "Polyphenol Composition and Antioxidant Activity of Tapirira guianensis Aubl. (Anarcadiaceae) Leaves." Plants 11, no. 3 (January 26, 2022): 326. http://dx.doi.org/10.3390/plants11030326.

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Tapirira guianensis (Anacardiaceae) is a natural resource from the Amazonian Forest and is locally known in French Guiana as “loussé” (creole), “tata pilili” (wayãpi), or “ara” (palikur). The tree is used by indigenous populations for medicinal purposes. To increase the potential of this tree for cosmetic, agro-food, or pharmaceutical uses, extracts were obtained through ultrasound-assisted extraction (UAE) from T. guianensis leaves using various extraction solvents such as water, methanol, and methanol–water (85/15; v/v). Chemical (DPPH, TEAC, ORAC) tests were applied to assess the anti-radical potential of these extracts. The polyphenol contents were determined by spectrophotometric (UV/Visible) and by means of chromatographic (UPLC-DAD-ESI-IT-MSn) methods. Tapirira guianensis leaf hydromethanolic extract produced the highest polyphenol content and exhibited antiradical activities in chemical assays (DPPH, TEAC, and ORAC) similar to (or higher than) those of a well-known antiradical plant, green tea. In T. guianensis, two classes of polyphenols were evidenced: (1) galloylquinic acids (identified for the first time in the studied species) and (2) flavonols and flavanols (present in small amounts). Flavonols seemed to play a major role in the antioxidant activity of DPPH. These findings provide a rationale for the use of T. guianensis in traditional medicine and to pave the way for seeking new biological properties involving this Amazonian tree.
6

Caetano, Ana Rita, Rafaela Dias Oliveira, Sónia Pires Celeiro, Ana Sofia Freitas, Susana M. Cardoso, M. Sameiro T. Gonçalves, Fátima Baltazar, and Cristina Almeida-Aguiar. "Phenolic Compounds Contribution to Portuguese Propolis Anti-Melanoma Activity." Molecules 28, no. 7 (March 30, 2023): 3107. http://dx.doi.org/10.3390/molecules28073107.

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Melanoma is the deadliest type of skin cancer, with about 61,000 deaths annually worldwide. Late diagnosis increases mortality rates due to melanoma’s capacity to metastasise rapidly and patients’ resistance to the available conventional therapies. Consequently, the interest in natural products as a strategy for drug discovery has been emerging. Propolis, a natural product produced by bees, has several biological properties, including anticancer effects. Propolis from Gerês is one of the most studied Portuguese propolis. Our group has previously demonstrated that an ethanol extract of Gerês propolis collected in 2018 (G18.EE) and its fractions (n-hexane, ethyl acetate, and n-butanol) decrease melanoma cell viability. Out of all the fractions, G18.EE-n-BuOH showed the highest potential as a melanoma pharmacological therapy. Thus, in this work, G18.EE-n-BuOH was fractioned into 17 subfractions whose effect was evaluated in A375 BRAF-mutated melanoma cells. The subfractions with the highest cytotoxic activity were analysed by UPLC-DAD-ESI/MSn in an attempt to understand which phenolic compounds could account for the anti-melanoma activity. The compounds identified are typical of the Gerês propolis, and some of them have already been linked with antitumor effectiveness. These results reaffirm that propolis compounds can be a source of new drugs and the isolation of compounds could allow its use in traditional medicine.
7

Ribeiro, Vera, Federico Ferreres, Tiago Macedo, Ángel Gil-Izquierdo, Andreia P. Oliveira, Nelson G. M. Gomes, Luísa Araújo, David M. Pereira, Paula B. Andrade, and Patrícia Valentão. "Activation of caspase-3 in gastric adenocarcinoma AGS cells by Xylopia aethiopica (Dunal) A. Rich. fruit and characterization of its phenolic fingerprint by HPLC-DAD-ESI(Ion Trap)-MSn and UPLC-ESI-QTOF-MS2." Food Research International 141 (March 2021): 110121. http://dx.doi.org/10.1016/j.foodres.2021.110121.

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8

Wang, Xiuhuan, Xiao Li, Rufeng Wang, Le Wang, Shusheng Fan, Xiaoping Wang, Xiao Xu, et al. "Human gastrointestinal metabolism of the anti-rheumatic fraction of Dianbaizhu (Gaultheria leucocarpa var. yunnanensis) in vitro: Elucidation of the metabolic analysis in gastric juice, intestinal juice and human intestinal bacteria by UPLC-LTQ-Orbitrap-MSn and HPLC-DAD." Journal of Pharmaceutical and Biomedical Analysis 175 (October 2019): 112791. http://dx.doi.org/10.1016/j.jpba.2019.112791.

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9

Xiao, Ying, Zhongzhi Hu, Zhiting Yin, Yiming Zhou, Taiyi Liu, Xiaoli Zhou, and Dawei Chang. "Profiling and Distribution of Metabolites of Procyanidin B2 in Mice by UPLC-DAD-ESI-IT-TOF-MSn Technique." Frontiers in Pharmacology 8 (May 4, 2017). http://dx.doi.org/10.3389/fphar.2017.00231.

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Dissertations / Theses on the topic "UPLC-DAD-MSn":

1

Miranda, Julie. "Recherche des déterminants moléculaires de la permissivité des vins rouges vis-à-vis de Brettanomyces bruxellensis." Electronic Thesis or Diss., Bordeaux, 2023. http://www.theses.fr/2023BORD0465.

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Des odeurs jugées néfastes par le consommateur et décrites comme des odeurs « d’écurie », « sueur de cheval » ou encore de « plastique brûlé » peuvent être retrouvés dans certains vins. Les composés responsables sont des phénols volatils, produits par une levure d’altération : Brettanomyces bruxellensis. Cette espèce est particulièrement bien adaptée à son milieu et résiste à de nombreux stress comme un fort taux d’alcool, un pH bas ou encore des teneurs importantes en SO2de façon plus ou moins marquée selon la souche considérée. L’espèce présente en effet une très grande diversité génétique, y compris à l’échelle du vignoble bordelais.Les principaux objectifs de la thèse étaient (1) d’évaluer la variabilité de permissivité des vins rouges bordelais face à la contamination par différentes souches de B. bruxellensis, (2) de montrer un éventuel lien entre la composition chimique des vins et leur permissivité à l’aide d’analyse métabolomiques non ciblées, et (3) d’étudier l’effet de différentes fractions obtenues à partir d’un vin difficile.Les souches étudiées ont montré des comportements très différents selon les vins rouges considérés. Ces différences ont pu être liées à plusieurs facteurs tel que le millésime, le château ou encore le lot de vin. Les analyses de la composition chimique ont permis d’écarter plusieurs composés non impliqués dans la permissivité mais aussi d’identifier des familles de molécules qui réduiraient la vulnérabilité de certains vins rouges de la région bordelaise
Odours deemed harmful by the consumer and described as "stable", "horse sweat" or "burnt plastic" can be found in wines. The responsible molecules are volatile phenols, produced by a spoilage yeast: Brettanomyces bruxellensis. This species is particularly well adapted to the wine environment and can resists many stresses such as a high alcohol level, a low pH or high levels of SO2, more or less efficiently depending on the strain considered. Indeed, the species displays a very high genetic diversity, even at the scale of the Bordeaux vineyard.The main objectives of this thesis were (1) to evaluate the variability of the permissiveness among Bordeaux red wines regarding the contamination by different strains of B. bruxellensis, (2) to show a possible relationship between the chemical composition of wines and their permissiveness, using non-targeted metabolomic analyses, and (3) to study the effect of different fractions obtained from a difficult wine.The studied strains showed very different behaviors depending on the red wines considered. These differences can be linked to several factors such as the vintage, the winery, or the wine batch. Chemical composition analyses made it possible to rule out several compounds not involved in permissiveness but also to identify families of molecules that would reduce the vulnerability of certain red wines from the Bordeaux area

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