Journal articles on the topic 'Ultraviolet radiation Safety measures'

Ultraviolet radiation (UVR) poses a major risk for outdoor workers, putting them at greater risk for skin cancer. In the general population, the incidence of both melanoma and nonmelanoma skin cancers is increasing. It is estimated that 90% of skin cancers in Canada are directly attributable to UVR exposure, making this cancer largely preventable with the appropriate precautions. A scoping review was conducted on the barriers and facilitators to UVR safety in outdoor workers to elucidate why these precautions are not in use currently. We discuss these results according to the Hierarchy of Controls as a means to outline effective and feasible prevention strategies for outdoor workers. In doing so, this review may be used to inform the design of future workplace interventions for UVR safety in outdoor workers to decrease the risk of skin cancer in this vulnerable population.

Purpose: The article aims to study the photobiological safety of ultraviolet radiation of UV lamps in agriculture. Design/methodology/approach: The research and analysis of the lighting characteristics of samples of LUF 80 and LE 30 lamps, which are the most widely used in the agrarian complex. Findings: Experimental studies have shown that the photobiological safety of LUF 80 lamps belongs to the low-risk group RG1, while LE 30 lamps show high risk and are thus assigned to group RG3. Research limitations/implications: It is advisable to continue studying the characteristics of lamps and lamp systems for various fields of agriculture on the market in Ukraine to assess their compliance with safety requirements. Practical implications: The application of the proposed approach allows increasing the level of labor safety in commercial greenhouses or any other industry by choosing the suitable lamps for agriculture that at present are not regulated by additional safety measures. Originality/value: The originality of the article is showing the results of the experimental data of the studies of light-technical characteristics of ultraviolet lamps for agriculture.

Exposure to ultraviolet radiation (UV) is essential for good health and formation of vitamin D while overexposure poses a risk to public health. Therefore, it is important to provide information to the public about the level of solar UV radiation. The ultraviolet index (UVI) is used to help avoid the negative effects of ultraviolet (UV) radiation on humans and to optimize individual exposure. There is limited ground measurement of solar UV radiation, but satellite Ozone Monitoring Instrument (OMIs) satellite products with a spatial resolution of 1 ° × 1 ° can be used to create UV index climatology at local noon time. In this study, we utilize OMI satellite products collected over the campus of King Abdulaziz University (KAU) (21.5° North and 39.1° East), Jeddah, Saudi Arabia, to estimate changes in exposure to UV over a period of 15 years (2004-2020). The results indicate a significantly increasing trend in UV index over this period. Between 2004 and 2020, daily “extreme” UV ( UVI > 11 , as defined by the World Health Organization (WHO)) occurred on 46.60% of days. The frequency of low UVI ( UVI < 2 ) was only about 0.06%. These results imply dangerous exposure levels to solar UV radiation on the KAU campus and call for safety measures to increase awareness and decrease direct exposure; for example, by implementing the United States Environmental Protection Agency (EPA) general guidelines.

Ultraviolet B (UVB) in sunlight is known to promote health when humans are exposed to optimum sunlight. Proper exposure to ultraviolet B is essential to produce vitamin D in the body, which is a particularly important factor for health. However, there has been an increase recently in the number of people who are lacking sunlight exposure due to staying indoors. Avoiding ultraviolet (UV) rays leads to health deterioration. To solve this problem, a portable ultraviolet measuring device that provides users with the UV intensity information of outdoor sunlight has been developed while UVB Light Emitting Diode (LED) lighting technologies capable of providing UVB radiation have been studied. However, existing technologies are mere methods for providing information on ultraviolet rays and artificially exposing to ultraviolet rays, and there is a risk for the UV radiation amount to not meet the daily required UV dose. Therefore, in this paper, a UVB LED general lighting system based on a UV exposure calculation algorithm that supports users’ daily required UV dose is proposed. The proposed system is composed of an IoT (Internet of Things) UV measuring device that measures the UV dose indoors, as well as outdoors, UVB LED general lighting which can safely provide UVB doses at indoors, and a smartphone which provides information on the cumulative UV dose and the estimated amount of vitamin D while it controls UVB LED general lighting. In addition, it is possible to support users’ vitamin D synthesis by providing as much UV light as its shortage through UVB LED general lighting, based on an individual’s UV exposure amount through outdoor sunlight, using a smartphone implementing a UV dose calculation algorithm. In order to confirm the performance of the proposed system, a simulation was conducted assuming that users with skin types 2 and 3 performed outdoor activities within 30 min and entered the room. The result confirmed that the proposed lighting can provide users of all ages with the UV dose required per day.

Biophoton emission leading to bystander effects (BEs) was shown in beta-irradiated cells; however, technical challenges precluded the analysis of the biophoton role in gamma-induced BEs. The present work was to design an experimental approach to determine if, what type, and how many biophotons could be produced in gamma-irradiated cells. Photon emission was measured in HCT116 p53+/+ cells irradiated with a total dose of 22 mGy from a cesium-137 source at a dose rate of 45 mGy/min. A single-photon detection unit was used and shielded with lead to reduce counts from stray gammas reaching the detector. Higher quantities of photon emissions were observed when the cells in a tissue culture vessel were present and being irradiated compared to a cell-free vessel. Photon emissions were captured at either 340 nm (in the ultraviolet A [UVA] range) or 610 nm. At the same cell density, radiation exposure time, and radiation dose, HCT116 p53+/+ cells emitted 2.5 times more UVA biophotons than 610-nm biophotons. For the first time, gamma radiation was shown to induce biophoton emissions from biological cells. As cellular emissions of UVA biophotons following beta radiation lead to BEs, the involvement of cellular emissions of the same type of UVA biophotons in gamma radiation-induced BEs is highly likely.

Ichthyotherapy (therapy with the so-called ‘Doctorfish of Kangal’,Garra rufa) has been shown to be effective in patients with psoriasis in the Kangal hot springs in Turkey. This study evaluates the efficacy and safety of ichthyotherapy in combination with short-term ultraviolet A sunbed radiation in the treatment of psoriasis under controlled conditions. We retrospectively analyzed 67 patients diagnosed with psoriasis who underwent 3 weeks of ichthyotherapy at an outpatient treatment facility in Lower Austria between 2002 and 2004. Main outcome measures are as follows: overall relative reduction in Psoriasis Area Severity Index (PASI) score; proportion of patients with an improvement in their PASI score of ≥75% (PASI-75) and ≥50% (PASI-50); patient-reported outcomes assessed with a custom questionnaire; and patient follow-up with a questionnaire sent out in March 2005. Safety was evaluated by reviewing adverse events and vital signs. Overall there was a 71.7% reduction in PASI score compared to baseline (P< 0.0001). Of the 67 patients studied, 31 (46.3%) achieved PASI-75 and 61 patients (91%) achieved at least PASI-50. Patients reported substantial satisfaction with the treatment. The reported mean remission period was 8.58 months [95% confidence interval (CI) 6.05–11.11]. A total of 87.5% of patients reported a more favorable outcome with ichthyotherapy, when asked to compare ichthyotherapy to other previously tried therapies. Sixty-five percent stated that after the relapse their symptoms were less severe than before treatment. There were no significant adverse events. The benefit demonstrated in this study along with the favorable safety profile suggests that ichthyotherapy could provide a viable treatment option for patients with psoriasis.

The purpose of this study is to investigate the potentiality of Gafchromic external beam therapy 3 (EBT3) film to measure low dosage of solar ultraviolet (SUV; 0-10 600 mJ/cm2) and x-ray (0–750 mGy) radiation. In this experiment, 2 groups of EBT3 films were prepared with size 2 cm × 1 cm. The first group of films was exposed by incremental SUV dose in the middle of the day. The other group was irradiated by x-ray at 100 kVp, 100 mA, and 2 S of tube voltage, tube current, and exposure time, respectively. The measured SUV consists of 90% ultraviolet A (UVA) and 10% ultraviolet B. The film discoloration was represented by visible absorbance spectroscopy technique using Jaz spectrometer from Ocean Optics Inc. Simple linear regression produced high accuracy with coefficients of determination, r 2 of 0.9804 and root mean square error (RMSE) of 434.88 mJ/cm2 for the measurement of SUV dose. On the other hand, r 2 of 0.98 and RMSE of 31 mGy was produced for the measurement of x-ray dose. The application of multiple linear regression enhanced the measurement accuracy with R 2 of 99% and 99.7% and RMSE of 327.06 mJ/cm2 and 15.045 mGy for SUV and x-ray dose, respectively. The spectral analysis shows a promising measurement at selected wavelengths for SUV and x-ray dose.

В статье рассматривается комплекс вопросов, способствующих повышению безопасности рыбных консервов как важнейшего показателя качества пищевого продукта и оптимизации расхода ресурсов. Показана целесообразность замены традиционного метода орошения блоков замороженной рыбы на электроконтактный способ, который существенного повышает производительность и улучшает качество размороженного сырья. Уменьшение ручного труда в рыбоконсервном производстве может быть достигнуто использованием роботов и робототехнических комплексов на стадиях приемки и порционирования сырья, фасования продукта, проверки герметичности и удаления негерметичных консервов. Применение системы технического зрения позволяет организовать непрерывный дистанционный контроль закаточного шва и изменять параметры настройки закаточной машины с целью достижения необходимой герметичности. Показано, что безопасность производства консервов может быть повышена облучением рабочих поверхностей продукта и оборудования ультрафиолетовым излучением. На безопасность консервов оказывают влияние практически все технологические операции рыбоконсервной линии. Анализ работ по технологии продуктов из гидробионтов и созданию автоматизированных консервных линий позволил выделить мероприятия по дальнейшему совершенствованию производства и хранения рыбных консервов. The article deals with a set of issues that contribute to improving the safety of canned fish as an important indicator of food quality and the resource consumption optimization. The utility of replacing the traditional method of irrigation of frozen fish blocks with an electric contact method is shown, the latter significantly increasing productivity and improving the quality of thawed raw materials. Reduction of manual labor in fish canning production can be achieved by using robots and robotic systems at the stages of acceptance and portioning of raw materials, product packaging, leak testing and removal of leaky canned food. The use of a technical vision system allows to organize continuous remote control of the sealing seam and change the settings of the sealing machine in order to achieve the necessary tightness. The safety of canned food production is shown to be increased by irradiating the working surfaces of the product and equipment with ultraviolet radiation. The safety of canned food is influenced by almost all technological operations of the fish canning line. The analysis of investigations into the technology of products from hydrobionts and the development of automated canning lines has allowed to identify measures to further improve the production and storage of canned fish.

The association between skin cancer and ultraviolet radiation (UVR) is well established, and sun protection behavior represents an important preventative measure. In children, caregivers play a key role in this regard. The subject of this study was threefold: whether caregivers of 1 to 11 year-old children are more likely to use sun protection measures compared to non-caregivers, whether considering oneself a role model is associated with sun protection behaviors, and whether their sun protection and risk behaviors are related to children’s behaviors. We used data from the 2020 wave of the National Cancer Aid Monitoring (NCAM) comprised of 4000 individuals (including 554 caregivers of at least one child aged 1–10 years) aged 16 to 65 years and living in Germany. Data were collected through telephone interviews between October and December 2020. No significant differences between caregivers and non-caregivers regarding sun protection and risk behaviors were identified (except tanning on vacation). In both groups, sun protection behaviors were deficient. Caregivers who considered themselves role models concerning sun safety were more likely to use sun protection measures (e.g., using sunscreen on the face: OR = 5.08, p < 0.001). In addition, caregivers’ sun protection behaviors were positively associated with children’s behaviors. Caregivers being highly protected against UVR were more likely to report the use of different measures by/in the child (mean = 4.03), compared to caregivers with medium (3.41) and low (2.97, p < 0.001) protection levels. However, we also found that caregivers’ risk behavior was associated with children’s reported risk behavior. For future prevention, it might be worth focusing on the aspect of caregivers serving as role models. A comprehensive public-health strategy is needed, including key figures such as pediatricians to prevent today’s children from developing skin cancer in later life.

Background: MiR-664 has been demonstrated to play an important role in dermal diseases. However, the functions of miR-664 in ultraviolet B (UVB) radiation-induced keratinocytes damage remain to be elucidated. Objective: The present study aimed to investigate the molecular mechanisms under the UVB-induced keratinocytes damage and provide translational insights for future therapeutics and UVB protection. Methods: HaCaT cells were transfected with miR-664, either alone or combined with UVB irradiation. Levels of messenger RNA and protein were tested by quantitative real-time polymerase chain reaction and Western blot analyses. Cell proliferation, percentage of apoptotic cells, and expression levels of apoptosis-related factors were measured by Cell Counting Kit-8 assay, flow cytometry assay, and Western blot analysis, respectively. Results: We found that a significant increase in miR-664 was observed in UVB-induced HaCaT cells. Overexpressed miR-664 promoted cell vitalities and suppressed apoptosis of UVB-induced HaCaT cells. Additionally, the loss/gain of armadillo-repeat-containing protein 8 (ARMC8) rescued/blocked the effects of miR-664 on the proliferation of UVB-induced HaCaT cells. Conclusions: Our data demonstrate that miR-664 functions as a protective regulator in UVB-induced HaCaT cells via regulating ARMC8.

Eggshell sanitizing practices are necessary to improve microbiological safety of fresh hen eggs and their products. In this work, the effects of 100 mg/liter free chlorine (chl), 3% sodium chloride (NaCl), 1, 5, and 12% trisodium phosphate (TSP) in wash solutions, and UVR (ultraviolet radiation; 4,573 μW/cm2) were studied at different times on uninoculated and Yersinia enterocolitica-inoculated eggs. On uninoculated eggs, the best results were obtained with 100 mg/liter chlorine and UV exposure for &gt;25 min, with reductions of 1.28 and 1.60 log cycles, respectively, compared to the average bacterial count (4.55 log CFU/egg) on the control (untreated eggs). On Y. enterocolitica-inoculated eggs, highest reductions of the average bacterial count (7.35 log CFU/egg) were obtained with 5 and 12% TSP and 100 mg/liter chl. The decrease obtained with 12% TSP (3.74-log reduction) was significantly higher (P &lt; 0.05) than those obtained with the remaining treatments. Y. enterocolitica was more resistant to UVR than the eggshell natural mesophilic aerobic microflora, except when low inoculum (4.39 log CFU/egg) was assayed. Changes in eggshell microstructure were measured by the blue lake staining method. The presence of Yersinia and Salmonella in eggshell natural flora was also investigated.

ObjectivesOccupational exposure to cosmic and ultraviolet radiation may increase airline pilots’ risk of cutaneous melanoma. Meta-analyses of available data show a higher than average incidence of melanoma in airline pilots, but the most recent systematic review revealed that few contemporary data are available. Moreover, all relevant studies have been conducted in Northern Hemisphere populations. We therefore aimed to examine if Australian commercial pilots have a raised incidence of melanoma compared with the general population.MethodsWe examined all melanoma histologically diagnosed among Australian-licensed commercial pilots in the period 2011–2016 by manually reviewing de-identified data in the medical records system of the Australian Civil Aviation Safety Authority. We estimated age-specific incidence rates and compared these with corresponding population rates using standardised incidence ratios (SIRs) as measures of relative risk. Expected numbers were calculated by multiplying age- and calendar period-specific person-years (PYs) with corresponding rates from the entire Australian population; 95% CI were calculated assuming a Poisson distribution of the observed cases.ResultsIn this cohort of Australian-licensed commercial pilots observed for 91 370 PYs, 114 developed a melanoma (51 invasive, 63 in situ). More than 50% of melanomas occurred on the trunk, and the predominant subtype was superficial spreading melanoma. The SIR for invasive melanoma was 1.20 (95% CI 0.89 to 1.55) and for melanoma in situ, 1.39 (95% CI 1.08 to 1.78).ConclusionAustralian-licensed commercial pilots have a modestly raised risk of in situ melanoma but no elevation of invasive melanoma compared with the general population.

Today, it is becoming more and more obvious that those countries that develop electronics, nanotechnology and biotechnology will have an advantage. The studies carried out have shown that the use of nanotechnology and nanomaterials in animal husbandry currently allows solving a number of acute problems and provides a significant effect. In animal husbandry, it is advisable to use nanotechnology in technological processes, where they provide additional advantages. When forming the microclimate in the premises for keeping animals and poultry, the use of nanotechnology makes it possible to replace the energy-intensive supply and exhaust ventilation system with an energy-saving airconditioning system while ensuring the regulatory parameters of the microclimate: temperature, humidity, gas composition, microbial content, dustiness, air velocity, eliminating odors while maintaining the heat release of animals. Nanoelectrotechnology in the technological processes of poultry farming using high and medium-high frequency electromagnetic radiation allows for: ultraviolet irradiation of hatching eggs and young poultry in order to decontaminate them from pathogens and stimulate perinatal (during incubation) development of young animals (studies have shown that hatchability of chickens increases to 94, and their preservation is up to 99%); disinfection and pasteurization of eggs; division of young poultry by sex. Taking into account the problems of environmental pollution, emissions with an unpleasant smell and gases affecting global warming, existing in animal husbandry, the most effective at present is the use of film-forming solutions of catalytic action. A promising development is the development of environmentally friendly nanotechnology for electroconservation of silage mass of green fodder with an electroactivated preservative instead of expensive organic acids, which require strict safety measures.

Melanoma and non-melanoma cancers are global healthcare problems nowadays. Ultraviolet (UV) radiation exposure is one of the risk factors of development of these pathologies. An introduction of sunscreen creams with cerium dioxide nanoparticles (CDN) in medical practice will widen the spectrum of measures of prevention of UV-induced injuries, namely, skin malignancies. Development of such products includes the complex of non-clinical studies in the field of safety pharmacology. The study on an influence of the cream with CDN on some vital signs of rats in the setting of a topical application in a chronic experiment. Standardized CDN 6–15 nm in size were synthesized in TOV ‘NanoMedTech’, the dermal cream with 0.25% CDN was developed in SSI ‘Institute for Single Crystals’ of NAS of Ukraine. The experiment was carried out on 100 white female Wistar rats. Animals were allocated into 5 groups with 20 rats each: an intact control, an application of the cream with CDN in the doses of 0.1, 0.5, and 1.0 g/kg, an application of a cream base (placebo). The cream with CDN was applied on skin once a day during 6 months. Toxicity was evaluated on the basis of following indices: survivability, overall health and behavior of animals, ingestion of food and water, body mass dynamics, hematological and serum biochemical indices, macroscopic structure and mass coefficients of internal organs. No mortality, deterioration of overall health, changes in behavior and ingestion of food and water were observed in groups of an application of the cream with CDN; body mass dynamics were positive. There were no critical differences in hematological (hemoglobin; erythrocyte, thrombocyte, leukocyte count; leucogram) and serum biochemical (alanine aminotransferase, aspartate aminotransferase, total protein, albumin, creatinine, glucose, cholesterol, potassium, sodium, phosphorus, chlorides) indices between groups of an application of the cream with CDN and control groups over a period of the experiment. A macroscopic evaluation of condition of internal organs didn’t show any toxic effect of the cream with CDN, and mass coefficients were standard for rats and basically didn’t differ from those in control groups. The cream with CDN in the doses of 0.1, 0.5, and 1.0 g/kg in the setting of a topical application in rats once a day during 6 months is safe – it doesn’t cause animal mortality, doesn’t influence overall health, behavior of animals, ingestion of food and water, doesn’t contribute to negative body mass dynamics, doesn’t have a negative impact on hematological and serum biochemical indices, and doesn’t alter a macroscopic structure and mass coefficients of internal organs of rats.

The beneficial effect of ultraviolet radiation on our skin manifests itself in the synthesis of vitamin D. However, the detrimental effect of this radiation is much more severe. A longer duration of the effect of this radiation speeds up photoaging of skin depending on its phonotype. Symptoms of burning accompanied by tiredness, headaches, changes in temperature, skin damage observed testify to the negative effect of ultra-violet radiation. The unsuitable acquisition of measures of protection with SPF (Sun Protection Factor) numbers and their seasonal application presuppose the formation of wrinkles. This issue remains relevant today as well, because the results of ultraviolet radiation are diagnosed ever more often. They testify to careless skin care. The slightest skin redness, swelling or brownness is reaction of the skin to harmful ultraviolet radiation. The aim of the investigation was to examine the effect of ultraviolet radiation on skin. The investigation was carried out in virtual space on the Internet website www.apklausa.lt in 2021 (2 months). A total of 209 respondents took part in the investigation. The results and conclusions of the investigation are as follows: due to the nature of work, about half of the respondents were exposed to ultraviolet radiation the whole day or 3–4 hours a day. One the third of the respondents used the solarium procedures once per week, provided themselves with measures of protection in shops; however, they did not set great store by the protective effect of SPF filters. One the sixth of the respondents used measures of protection when their skin suffered serious damage.

ABSTRACT Endodontists belong to the category of specialist dentists who depend much on dental radiography. Starting from the stage of disease diagnosis, radiography is of much importance in different stages of endodontic therapy, and further on radiographic evaluation is a tool for assessment of endodontic treatment. There is a heavy dependency on dental radiography in some form or other in the speciality of endodontics. As is the case with any ionizing radiation, radiation hazard is a phenomenon that matters a lot to this group of dental professionals. There needs to be a change in our attitude toward radiation safety measures, as many of our professional colleagues are seen much not to be bothered about the cumulative outcomes of radiation hazard, which can create havoc in our professional and personal lives. This article outlines the potential hazards that can happen by routine radiographic utilization in endodontic setup and tries to highlight the measures that need to be taken to mitigate the negative effects. How to cite this article Manayanipuram NJ, Dhanapal P, George L, Charlie KM, Cherian AA. Radiation Safety: Endodontic Perspective. Cons Dent Endod J 2017;2(1):8-11.

Senile cataract has become a serious public health problem as the elderly population is increasing worldwide. As lens with dark iris is reported to have a higher prevalence of cataract, public health concern about cataract in Asia is a bigger issue. Among factors assumed to be involved in the pathogenesis of cataract, ultraviolet radiation (UV) has received much attention in accordance with the recent problem of ozone column depletion. It has been agreed that UV induces cataract in animal and biochemical experiments. However, in epidemiological studies, such agreement has not been reached. There are many factors that should be considered and controlled when investigating the association between cataract and UV. In this review, we summarize major findings obtained so far on the relationship between UV and cataract, and we discuss important factors that may be the cause of disagreement in epidemiological studies. We also point out some of the research foci which should be clarified and propose protective measures against UV induced cataract.

Solid-phase chemical reaction speed control is one of the most essential problems of physics and chemistry of solid bodies. Special attention is paid to the studies of sensitivity and stability of explosive substances (ES). Fundamental issues of studies of azides of heavy metals (AHM) are connected with developing ways of controlling new chemical reactions – solid-phase chain reactions in which electron excitations of a crystal lattice serve as active particles. Applied value is determined by safety issues of ES that include such wide range of problems as storage, transfer, destruction, etc.The result of this work is the use of the experimental results for purposeful change of energetic material

Background: Steroid-refractory acute graft-versus-host disease (SR-aGvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplant in pediatric patients. Second-line therapies cause further immunosuppression, leaving patients vulnerable to life-threatening infections. Extracorporeal photopheresis (ECP) with methoxsalen (Uvadex®) sterile solution, in which apheresed leukocytes are photosensitized, exposed to ultraviolet A radiation ex vivo, and reinfused, is used to treat aGvHD because it has a low risk of infection, unlike systemic immunosuppressants. Safe use of ECP in children is not yet established. Aims: To report interim 4-week data from a 12-week phase 3 study evaluating the efficacy and safety of ECP using the photosensitizing agent methoxsalen with the Therakos® Cellex® Photopheresis System (Cellex; Mallinckrodt Pharmaceuticals, Bedminster, NJ) in pediatric/young adult patients with SR-aGvHD (NCT02524847). Methods: In this single-arm, open-label study, patients (aged 1-21 years; SR-aGvHD International Bone Marrow Transplant Registry [IBMTR] grade B-D) received ECP 3 times/wk for 4 weeks, followed by 2 times/wk for 8 weeks. Steroids were tapered according to physician discretion if SR-aGvHD responded to ECP. The primary endpoint was proportion of patients with an overall response (OR), defined using the Modified IBMTR Severity Index as complete response (CR; complete resolution of aGvHD in all evaluable organs, without next-line systemic treatment) or partial response (PR; improvement of 1 stage in ≥1 aGvHD target organ without progression in others or addition of next-line systemic treatment), after 4 weeks. The primary endpoint was considered significant if P<0.005 for CR+PR vs the null hypothesis (10% response rate), which corresponded to CR+PR >48%. Secondary outcome measures included safety, duration of response, steroid-sparing effect, and organ-specific response. Results: Of 25 patients enrolled, 25 were evaluable for safety (patients who received ≥1 ECP treatment) and 23 were evaluable for efficacy. Patients' mean age was 9.2 years, 44% were female, mean body mass index was 18.3 kg/m2, and the majority (n=18) had Grade 3 aGvHD. Twelve patients (48%) completed all study visits; 5 withdrew early (2 deaths, 1 CR; 3 withdrew due to inadequate efficacy, 2 of whom started second-line therapy, and 3 no longer required treatment) A median of 27 ECP treatments were administered (range 3-28). OR was 61% (14/23 evaluable patients); there were 3 CRs (13%) and 11 PRs (48%; P<0.00001 vs null hypothesis; 95% CI: 36.6, 77.9). OR based on initial organ involvement and overall severity is in the Table. Of the 14 patients who responded by 4 weeks, 9 (64%) and 8 (57%) maintained response at 8 and 12 weeks, respectively. Time to disease progression was a median of 89 days (95% CI: 44.0, 104.0) after enrollment. Median duration of first response was 22.0 days (95% CI: 8.0, 49.0). Among 22 patients evaluable for steroid dose, 9 (41%) had ≥50% reduction in dose by week 4. 103 AEs (11 serious), including 2 deaths (cerebral aspergillosis; disease progression leading to respiratory failure), occurred in 19 patients. Of these, 99 (96.1%), including 2 on-study deaths, were considered unrelated to study treatment, and 4 (nausea, hypocalcemia, hypertension, anemia) possibly related. Conclusions: After 4 weeks of ECP using methoxsalen sterile solution and the Therakos Cellex Photopheresis System, the OR rate was 61%. These encouraging data warrant further investigation in pediatric/young adult patients with SR-aGvHD. Disclosures Kitko: Mallinckrodt: Honoraria; Novartis: Consultancy, Honoraria. Boodée:Mallinckrodt Pharmaceuticals: Employment. OffLabel Disclosure: UVADEXÃ'® (methoxsalen) Sterile Solution is indicated for extracorporeal administration with the THERAKOSÃ'® UVAR XTSÃ'® or THERAKOSÃ'® CELLEXÃ'® Photopheresis System in the palliative treatment of the skin manifestations of Cutaneous T-Cell Lymphoma (CTCL) that is unresponsive to other forms of treatment. Extracorporeal photopheresis (ECP) with methoxsalen (UvadexÃ'®) sterile solution is used to treat acute graft-versus-host disease (aGvHD), but there are few clinical trials in pediatric patients. This abstract reports on the interim results of a phase 3 clinical trial of ECP with methoxsalen used with the TherakosÃ'® CellexÃ'® Photopheresis System in pediatric/young adult patients with steroid refractory aGvHD.

Ultraviolet-C radiation and ultrasound technology are widely accepted and continuously being appraised as alternatives to conventional thermal techniques for decontamination of fruits and vegetables. However, studies in these areas have presented challenges related to quality, safety, limited capability, and cost of energy. This review paper presents an up-to-date summary of applications of ultraviolet-C radiation and ultrasound technology for postharvest handling of fruits and vegetables from relevant literature. The limitations associated with applications of ultraviolet-C radiation and ultrasound technology individually has prompted their combination alongside other antimicrobial strategies for enhanced bactericidal effect. The combination of ultraviolet-C radiation and ultrasound technology as a hurdle approach also provides enhanced efficiency, cost effectiveness, and reduced processing time without compromising quality. The review includes further scope of industrial-led collaboration and commercialization of ultraviolet-C radiation and ultrasound technology such as scale-up studies and process optimization.

The deleterious effects of long-wave (320–400 nm) ultraviolet (UV) radiation on human skin have been recognized for decades. Human exposure to UV radiation may induce skin pigmentation and sunburn, cutaneous connective tissue alterations (photoaging), immunosuppression, and the development of skin cancers. Public awareness campaigns on the need for photoprotection advocate the regular use of sunscreens. Consumer demand and an expanding knowledge of the adverse effects of UV exposure have fueled the continual development of novel sunscreen formulations. Two organic UV filters, terephthlylidene dicamphor sulphonic acid (Mexoryl SX, L'Oréal, Paris, France) and drometrizole trisiloxane (Mexoryl XL, L'Oréal), provide effective protection from UV irradiation and offer improved safety profiles in terms of protection from UVA radiation. This article details the photoprotective benefits of Mexoryl SX and Mexoryl XL.

Increased ultraviolet radiation potentially detrimental to health is a direct effect of the reduced ozone layer of the Earth?s atmosphere. Stratospheric ozone over the territory of Serbia and immediate surrounding depleted in the considered period of 1979-2008; its amount reduced by 7.6%. Solar and volcanic activities have significant effect on the interannual variability of the stratospheric ozone. Ozone layer over Serbia is 13.8% thicker than the planetary layer, with the ozone hole forming once in five years on average without serious health implications.

The rise in the number of cases of skin cancers, both melanomas and nonmelanomas, has prompted increased awareness and educational efforts to limit sun exposure. Because 80% of lifetime sun exposure occurs before the age of 18, educating parents and adolescents to incorporate sun-protective behaviors into daily routines is particularly important. Education of parents is essential to establishing healthy behavior patterns in children. Educational interventions are recommended that encourage the following: using sunscreen, wearing hats with wide brims and clothing that blocks or absorbs ultraviolet rays, using sunglasses that block ultraviolet radiation, and seeking shade. Continued efforts are important through adolescence to maintain the established behaviors. School nurses are in a position to affect the health education curriculum, as well as school policies that promote sun safety behaviors.

A ultraviolet filter is defined as a substance, mixture, or material that blocks or absorbs radiation in the UV range, and its key purpose is protect the skin from the harmful effects of the radiation. Consumer concern is mainly regarding organic filters and the frequent problems with their low photo-stability, which is highly undesirable in terms of safety. The aim of this work was to discuss the term “photo-stability” and to assess the safety of the three most popular compounds classified as ultraviolet filters. Cited studies and issued opinions by Scientific Committees on Customer Safety confirm the safety for human health of Avobenzone, Oxybenzone and Octinoxate in strictly defined maximum concentrations. Side effects of these filters, like accumulation in the bloodstream, may occur after prolonged use. In order to improve the level of photo-stability of Avobenzone and Octinoxate the following methods are used: the use of photo-stabilizers and excited state quenchers, encapsulation of the molecule in micelles or the addition of antioxidants such as vitamin C. Although these compounds do not pose a serious threat to human health, two of them (Oxybenzone and Octinoxate) have a negative impact on aquatic ecosystems.

Genotoxic Effects of Radiofrequency-Electromagnetic Fields. IntroductionRadiation is energy emission in the form of electromagnetic waves emitted from the solar system and natural resources on earth. The currents produced by the elementary particles formed by the electric current create the magnetic field. Earth's surface is under the influence of the geomagnetic field emanating from the sun. However, the outer liquid also has a magnetic field created as a result of heat transfer in the core. Therefore, all living organisms on earth live under the influence of electromagnetic fields (EMF). Today, besides these natural energy resources, rapidly developing technological developments provide most of the convenience in our lives and expose people to artificial electromagnetic fields. However, man's magnetic field is also under the influence of other natural and artificial magnetic fields around him. In particular, by ionizing radiation, which carries enough energy to break down the genetic material, die cells as a result of DNA damaging, and other diseases, especially cancer, can develop as a result of tissue damage. Electromagnetic Fields in Our LivesToday, apart from natural geomagnetic fields, radiation is emitted from many technological devices. The spectrum of these fields includes many different types of radiation, from subatomic radiation such as gamma and X-rays to radio waves, depending on their wavelengths. Though, as a result of the rapid increase of technological growth, the duration and amount of exposure to EMF is also steadily increasing. On the other hand, wireless gadgets such as computers, smartphones and medical radiological devices have become a necessity for humans. Almost everyone is exposed to radiofrequency electromagnetic fields (RF-EMF) from cell phone and base station antennas or other sources. Thus, the damage caused by the radiation to the environment affects living organisms even many kilometres away unlimitedly. All organisms in the world live under the influence of these negative environmental changes and a large part of the world population is exposed to radiofrequency (RF) radiation for a long time in their daily lives. So, though we are not aware of it, our organs and tissues are constantly exposed to radiation. Therefore, radiation adversely affects human, animal and plant health and disrupts the environment and ecological balance. An example of negative effects, radiation can cause genetic changes in the body (Figure 1). Radiation is divided into ionizing and non-ionizing. Ionizing radiations cause electron loss or gain in an atom or group of atoms in the medium they pass through. Thus, positively or negatively charged ions are formed. High energy X, gamma, ultraviolet and some visible rays in the ionized region of the electromagnetic spectrum can be counted. Since gamma rays, X rays and ultraviolet rays can ionize the molecules in living things more, they can easily disrupt the chemical structure of tissues, cells and DNA molecules in living organisms. Therefore, they can be very dangerous and deadly to living things. The energy of the waves in the non-ionizing region of the electromagnetic spectrum is low and the energy levels are insufficient for the ionization of molecules. Electricity, radio and TV waves, microwaves, and infrared rays are not ionizing because they have low energy. Waves emitted from electronic devices (cell phones, computers, microwave ovens, etc.) are absorbed by the human and animal body. The amount of energy absorbed by the unit biological tissue mass per unit time is called the specific absorption rate (SAR), and its unit is W/kg. Risks of Electromagnetic Fields on Living ThingsDepending on the structure of the tissues and organs, the radiation must reach a certain threshold dose for the effect to occur. Radiation levels below the threshold dose are not effective. Depending on the structure of the tissues and organs, the radiation must reach a certain threshold dose. The effects of small doses of waves are negligible. However, the clinical effects of waves above a certain threshold may increase. High dose waves can cause cell death in tissues. Damages in the cell may increase the risk of cancer and hereditary damage after a while, and somatic effects in people exposed to radiation may cause cancer to appear years later. There is much research on the effects of RF fields. In vitro and in vivo studies on rats, plants and different tissues of humans; suggests that the RF fields are not genotoxic and the fact that harmful effect is due to the heat effect. The contradictory results on this issue have brought about discussions. Therefore, there are still concerns about the potential adverse effects of RFR on human health. A good understanding of the biological effects of RF radiation will protect against potential damages. Due to these uncertainties, with the electromagnetic field project of the World Health Organization, experimental and modelling studies on the biological effects of RF radiation have been accelerated. In 2011, the International Agency for Research on Cancer decided that RF-EMR waves could be potentially carcinogenic to humans (2). Considering that almost everyone, including young children, uses mobile phones in addition to other technological devices, the danger of electromagnetic waves has increased social interest. Genotoxic Effects of EMFIn addition to stimulating apoptosis and changes in ion channels, RF-EMF waves also have a potential effect on genetic material. The radiation absorbed by organisms causes the ionization of target molecules. In particular, biological damage may occur as a result of stimulation/ionization of atoms and disruption of molecular structures while ionizing radiation passes through tissue. As a result of ionization in the cell, electron increases and free electrons cause damage, especially in macromolecules and DNA. Free electrons move directly or indirectly. Free electrons directly affect the phosphodiester or H-bonds of DNA. As a result, the phosphodiester bonds of DNA in the cell are broken, single or double-stranded breakages and chemical toxins increase. DNA double-strand breaks are the most relevant biologic damage induced by ionizing radiation (3,4). There are no cells that are resistant to radiation. The nucleus of the cell and especially the chromosomes in dividing cells are very sensitive to radiation. One of the most important effects of radiation on the cell is to suppress cell growth. In particular, growth is impaired in cells exposed to radiation during cell division (mitosis). Consequently, cells with a high division rate are more sensitive to radiation. DNA damage in somatic cells can lead to cancer development or cell death. Cell death can occur as a result of breaking down DNA because ionizing radiation has enough energy to break down the cell's genetic material. Thus, tissues are damaged and cancer development may be triggered. DNA damage caused by radiation in cells is repaired by metabolic repair processes. If the breaks in DNA as a result of DNA damage caused by radiation in cells are not too large, they can be repaired by metabolic repair processes. Still, errors may occur during this repair. Chromosomes containing different genetic codes and information may also occur. In the cell, the released electrons interact with water molecules, indirectly causing the water to be reactively divided into two parts. Free radicals carry an electron that is not electrically shared in their orbits. Free radicals can cause genetic damage in DNA such as nucleotide changes, double and single-strand breaks. Radiation can cause chromosomes to break, stick together and rearrange. All these changes can lead to mutations or even further, the death of the cell. However, in addition to ionizing radiation, extracellular genotoxic chemicals and intracellular oxidative metabolic residues can also create stress in cells during DNA replication and cell division. Damage may occur during DNA replication under such environmental stress conditions. To date, conflicting results have been reported regarding the genotoxic effects of RF-EMF waves on genetic material. It has been reported that the energy of low EM fields is not sufficient to break the chemical bonds of DNA, but the increase in exposure time is effective on the formation of oxygen radicals and the disruptions in the DNA repair process. The absorption of microwaves can cause significant local warming in cells. For example, an increase in temperature has been observed in cells in culture media exposed to waves of high SAR levels. However, there is evidence that reactive oxygen species are formed in cells indirectly and experimentally exposed to RF-EMF waves. Free oxygen radicals can create nucleotide entries in DNA as well as bind cellular components to DNA bases (5). The frequency of polymorphisms observed in DNA repair mechanism genes in children with acute leukaemia living close to high energy lines reveals the effect of this energy on the repair process. Significant evidence has been reported that genotoxic effects occur in various cell types when exposed to RF-EMF waves (6-10). Here, it has been reported that cells exposed to RF-EMF waves (1.800 MHz, SAR 2 W/kg) cause oxidative damage in mitochondrial DNA, DNA breaks in neurons and DNA breaks in amniotic cells (6,10). Similarly, the damage has been reported in lymphocytes exposed to various RF-EMF waves (8). However, exposure to RF-EMF waves is known to cause chromosome imbalance, changes in gene expression, and gene mutations. Such deleterious genetic effects have also been reported in neurons, blood lymphocytes, sperm, red blood cells, epithelial cells, hematopoietic tissue, lung cells, and bone marrow (1,11,12). It has been found that exposure to RF-EMF radiation also increases chromosome numerical aberrations (6,13). It has also been reported that increased chromosome separation in mouse oocytes exposed to EM and increased DNA fragmentation and apoptosis in fly egg cells (14,15). However, increased DNA breaks have been reported in the blastomeres of embryos of pregnant mice exposed to a frequency of 50 Hz, and a decrease in the number of blastocysts has been reported (16). Genetic damages to sex cells can lead to persistent genetic diseases in subsequent generations. Today, X-ray devices used for medical diagnosis have become one of the largest sources of radiation. These radiological procedures used for diagnosis constitute an important part of ionizing radiation. During these processes, the human body is visibly or invisibly affected by X-rays. As a matter of fact, X-rays have effects of disrupting the structure and biochemical activities of DNA, RNA, proteins and enzymes that are vital in the organism (17). Many studies on this subject have revealed that radiation has suppressive and mutational effects on DNA synthesis. These effects can cause serious damage to the cell as well as DNA and chromosome damage. In a recent study, chromosome damage was investigated in patients with X-ray angiography and personnel working in radiological procedures (18). Our findings showed that the beams used in interventional radiological procedures caused chromosomal damage and the rate of chromosomal abnormalities (CAs) increased significantly in patients after the procedure and this damage increased with the amount of radiation dose. Therefore, the radiation dose to be given to the patient should be chosen carefully. Besides, our findings showed that the frequency of CA is significantly higher in personnel working in radiological procedures. This reveals that interventional cardiologists are exposed to high radiation exposure. For this reason, we can say that the personnel working in radiological procedures (physician, health technician and nurse) are very likely to get diseases after years because they are exposed to low doses but long-term X-rays. Therefore, both the potential risks and safety of exposure to medical radiological devices must be continuously monitored. Furthermore, the fact that chromatid and chromosome breaks are very common among structural CAs in our findings suggests that they may be the cause of malignancy. Because, there are many cancer genes, tumour suppressor genes, enzyme genes involved in DNA repair and important genes or candidate genes responsible forapoptosis on these chromosomes. All this information shows that patients are more susceptible to DNA damage and inappropriate radiological examinations should be avoided. Therefore, X-ray and other diagnostic imaging techniques should not be applied unless necessary, and physicians and patients should be more careful in this regard. It has been reported that RF-EMR waves emitted from wireless communication device mobile phones have a genotoxic effect on human and mammalian cells (6,19). In a recent study; The effects of 900 and 1800 MHz cell phone frequencies on human chromosomes were investigated in amniotic cell cultures (6). Here, it has been reported that chromosome packing delays, damage and breaks occur in amniotic cells exposed to 900 and 1800 MHz every day at 3, 6 and 12 hours for twelve days. However, it was found that the frequency of 1800 MHz caused more CAs than 900 MHz, and the amount of damage increased with increasing usage time. These results confirm that GSM-like RF-EMR causes direct genotoxic effects in human in vitro cultures and has adverse effects on human chromosomes, and these effects increase in parallel with exposure time. This shows us that the mobile phone carries a risk for human health and these genetic damages can cause cancer. Therefore, necessary precautions should be taken for these harmful effects of mobile phones. Among these measures, the periods of mobile phone use should be kept short, especially the exposure of developing children and infants to mobile phones should be prevented, and avoiding excessive use of mobile phones may be one of the precautions against cancer. However, in order to evaluate it in more detail, the effects of mobile phones with environmental mutagens and/or carcinogens should be considered in subsequent researches. ConclusionToday, in parallel with the increasing technological developments, the demand of the society for electronic devices and phones and the frequency ranges of electronic devices are constantly increasing. Waves emitted from electronic devices are absorbed by human and animal bodies. Especially, the use of phones by contact with our body and the increase in usage time affects not only adults but also young children. Therefore, there is increasing concern in society about the negative biological effects of EM waves emitted from phones and other electronic devices. Results from all studies show that RF-EMF waves may be carcinogenic due to their genotoxic effect. Because cancer is a disease that occurs as a result of genetic damage. Considering these negative and harmful effects, regulations following international standards regarding the use of electronic devices should be made and society should be made aware of the risks.References Kim JH.; Lee K.; Kim HG.; Kim KB.; Kim HR. Possible Effects of Radiofrequency Electromagnetic Field Exposure on Central Nerve System. Biomol Ther. 2019, 27(3), 265-275. Baan R.; Grosse Y.; Lauby-Secretan B.; et al. WHO International Agency for Research on Cancer Monograph Working Group. Carcinogenicity of radiofrequency electromagnetic fields. Lancet Oncol. 2011, 12, 624–626. Berrington De Gonzalez A.; Darby S. Risk of cancer from diagnostic X-rays: estimates for the UK and 14 other countries. Lancet. 2004, 363, 345-351. Löbrich M.; Jeggo PA.The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer. 2007, 861–869. M Valko.; M Izakovic.; M Mazur.; CJ Rhodes.; J Telser. Role of oxygen radicals in DNA damage and cancer incidence. Cell. Biochem. 2004, 266, 37–56. Uslu N.; Demirhan O.; Emre M.; Seydaoğlu G. The chromosomal effects of GSM-like electromagnetic radiation exposure on human fetal cells. Biomed Res Clin Prac. 2019, 4, 1-6. Lee S.; Johnson D.; Dunbar K Dong H.; Ge X.; Kim YC.; Wing C.; Jayathilaka N.; Emmanuel N.; Zhou CQ.; Gerber HL.; Tseng CC.; Wang SM. 2.45 GHz radiofrequency fields alter gene expression in cultured human cells. FEBS Lett. 2005, 579, 4829-4836. Phillips JL.; Singh NP.; Lai, H. Electromagnetic fields and DNA damage. Pathophysiology. 2009, 16, 79-88. Ruediger HW. Genotoxic effects of radiofrequency electromagnetic fields. Pathophysiology. 2009, 16, 89-102. Xu S.; Zhou Z.; Zhang L.; Yu Z.; Zhang W.; Wang Y.; Wang X.; Li M.; Chen Y.; Chen C.; He M.; Zhang G.; Zhong M. Exposure to 1800 MHz radiofrequency radiation induces oxidative damage to mitochondrial DNA in primary cultured neurons. Brain Res. 2010, 1311, 189-196. Demsia G.; Vlastos D.; Matthopoulos DP. Effect of 910-MHz electromagnetic field on rat bone marrow. 2004, 2, 48-54. Zhao TY.; Zou SP.; Knapp PE. Exposure to cell phone radiation up-regulates apoptosis genes in primary cultures of neurons and astrocytes. Lett. 2007, 412, 34-38. Mashevich M.; Folkman D.; Kesar A.; Barbul A.; Korenstein R.; Jerby E.; Avivi L. Exposure of human peripheral blood lymphocytes to electromagnetic fields associated with cellular phones leads to chromosomal instability. Bioelectromagnetics. 2003, 24, 82-90. Panagopoulos DJ.; Chavdoula ED.; Nezis IP.; Margaritis LH. Cell death induced by GSM 900-MHz and DCS 1800-MHz mobile telephony radiation. Mutat Res. 2007, 626(1–2), 69–78. Sagioglou NE.; Manta AK.; Giannarakis IK.; Skouroliakou AS.; Margaritis LH. Apoptotic cell death during Drosophila oogenesis is differentially increased by electromagnetic radiation depending on modulation, intensity and duration of exposure. Electromagn Biol Med. 2015, 1-14. Borhani N.; Rajaei F.; Salehi Z.; Javadi A. Analysis of DNA fragmentation in mouse embryos exposed to an extremely low-frequency electromagnetic field. Electromagn Biol Med. 2011, 30(4), 246–252. Rowley R.; Phillips EN.; Schroeder AL. Effects of ionizing radiation on DNA synthesis in eukaryotic cells. Int J Radiat Biol. 1999, 75( 3), 267-283. Çetinel N.; Demirhan O.; Demirtaş M.; Çağlıyan ÇE.; Cüreoğlu A.; Uslu IN.; Sertdemir Y. The Genotoxic Effect Of Interventional Cardiac Radiologic Procedures On Human Chromosomes. Clinical Medical Reviews and Reports. 2020, 3(1), 1-10. Aitken RJ.; Bennetts LE.; Sawyer D.; Wiklendt AM.; King BV. Impact of radio frequency electromagnetic radiation on DNA integrity in the male germline. Int J Androl. 2005, 28(3), 171–179.

The field of Radiology and Nuclear medicine has advanced from era of X-rays to today's modern imaging techniques, most of which use the ionizing radiation. With the benefits of better diagnosis and treatment, it has caused manifold increase in radiation exposure to the patients and the radiology and nuclear medicine personnel. Many studies done till date have clearly documented the harmful effects of ionizing radiation from radiation exposure, especially cancer. This is more important in paediatric population as their tissues are more radiosensitive, and they have more years to live. Diagnostic and therapeutic radiological procedures including nuclear medicine are integral part of modern medical practices, exposing both patients and medical staff to ionizing radiation. Without proper protective measures, this radiation causes many negative health effects. Hence, proper knowledge and awareness regarding the radiation hazards and radiation protection is mandatory for health professionals, especially the nuclear medicine and radiology professionals. International Commission on Radiation Protection (ICRP) has recommended two basic principles of radiation protection, justification of the practice and optimization of protection. Faridpur Med. Coll. J. Jul 2019;14(2): 100-103

Ultraviolet disinfection has been proven to be effective for surface sanitation. Traditional ultraviolet disinfection systems generate omnidirectional radiation, which introduces safety concerns regarding human exposure. Large scale disinfection must be performed without humans present, which limits the time efficiency of disinfection. We propose and experimentally demonstrate a targeted ultraviolet disinfection system using a combination of robotics, lasers, and deep learning. The system uses a laser-galvo and a camera mounted on a two-axis gimbal running a custom deep learning algorithm. This allows ultraviolet radiation to be applied to any surface in the room where it is mounted, and the algorithm ensures that the laser targets the desired surfaces avoids others such as humans. Both the laser-galvo and the deep learning algorithm were tested for targeted disinfection.

Control of the radiation safety of workers is the one of the principal tasks of regulatory bodies responsible for the radiation safety and protection. This task is solved through the implementation of a set of organizational and technical measures, including:1) Organization and the execution of radiation monitoring; 2) Prediction of exposure doses to workers; 3) Selection of workers for the execution of radiation hazardous operations including emergency remedial works; 4) Planning of activities to implement the principle of the optimization of radiation protection; 6) Development and establishment of reference levels of exposure to radiation factors; 5) Organization of education and training of the personnel; 7) Continuous improvement of the occupational safety culture etc. The paper describes main actions of the management of radiation facilities aimed at the implementation of the above mentioned measures. Special attention is paid to the selection of the personnel of the required qualifications, possessing a sufficient reserve of an individual dose, to carry out radiation hazardous operations, to predict radiation doses to justify the development of the necessary protective measures and to plan actions to implement the principle of optimization of the radiation protection. The active use of the computer information and analytical system for the management of the protection from the occupational radiation is recommended. This system should include: 1. Database of individual occupational doses; 2. Database of radiation parameters characterizing the situation in workshops and at the industrial site of the radiation facility; 3. Software package for education and training of the personnel. The making of managerial decisions for the radiation protection of the personnel is aimed at increasing in the occupational reliability and, ultimately, improving the safety of radiation facilities, maintaining health and increasing the professional longevity of workers.

Abstract The article, based on the records of the EN 62471:2008, presents guidelines for photobiological safety of lamps and lamp systems. There are allowed safe exposure times presented and emission limit values for each of four risk groups, defined by the standard. The paper presents criteria for lamps irradiance or radiance measurement. Discussed risks with association of ultraviolet, visible and infrared radiation. For a detailed presentation of the potential risks associated with the blue light, there is made a comparison of spectra of selected light sources. On these basis, the blue light hazard assessment was presented for selected light sources.

Background : Food safety remained as critical concern to immune-compremissed patient. Food safety assurance can be achieved through inhibition of pathogenic bacteria by physical treatment such as UV light radiation. However, a study regarding the effect of UV light on growth of pathogenic bacteria in contaminated liquid food are scarce.Objective : To determine the effectiveness of UV light on contamination of pathogenic bacteria in liquid food for immune-compremissed patient.Methods : Randomized design with two factor which were holding time for 60 and 120 minutes and radiation exposure (0, 5, 10 and 15 minutes). The data was analyzed using ANOVA Result : The viscosity and pH of liquid foods were 20 centipoise and 7,15 respectively. Radiation of UV light on contaminated food that have been incubated for 60 and 120 minutes at 37oC showed significant increase (1-2 log cycle) on growth of pathogenic bacteria.Conclusion : Radiation of UV light on contaminated liquid food were not effective to inhibit or kill pathogenic bacteria during holding time (60 and 120 minutes).

Aim & Objective-This study has been undertaken to assess the knowledge and awareness about basics of radiation and safety measures in diagnostic radiology among allied health professionals including, Radiographers, and students of Radiology and imaging technology. Materials and Methods: A questionnaire based survey was performed to collect data of knowledge about the radiation awareness and safety measures using in diagnostic radiology, among allied health professionals including radiographers, and students of Radiology and imaging technology. Result- Knowledge about principle of radiation protection was very disappointing, because 30.60% of the participants know the basic principle of radiation protection (Justification, Optimization, and Dose Limit). 43.40% participants said that, ALARA is the basic principle of radiation protection while 26% participants said that, TDS (Time, Distance and Shielding) is the basic principle of radiation protection. Discussion-Majority of participants needs to improve their knowledge about the radiation awareness and safety measure. Keywords: Radiation, Safety, Protection, Radiation awareness.

As surface ultraviolet-B (UV-B) radiation levels increase due to the decline in the protective stratospheric ozone layer, ultraviolet radiation sunscreens will become more important for all plant species that grow in sunlight. Epicuticular waxes, which cover the aerial portions of all terrestrial plants, are ideally located to be sunscreens. The sun-screening ability of maize (Zea mays L.) epicuticular waxes was tested using the glossy1 mutant, which is specifically defective in juvenile wax production. A significant difference between the glossy1 mutant and wild type was seen in UV-induced leaf rolling and in some measurements of UV-induced DNA damage levels under enhanced UV. Isolated epicuticular wax layers absorbed significant amounts of UV, and leaves with wax absorbed more UV than leaves with little wax. Thus, by some measures, the epicuticular waxy layer acts as an ultraviolet radiation protectant in maize.

Purpose: This study aims to assess the awareness of the theatre team to radiation risk from C-arm as well as their adherence to radiation protection or safety measures in the study Centre. Methods: A non-experimental descriptive design was adopted for this study and a well-structured 27 item questionnaire was distributed to 52 members of the surgical theatre: Surgeons, Anesthesiologists, Theatre nurses and Radiographers in the selected hospital. Of this sample, 49 respondents returned their questionnaires. Results. Results from this study reveal a high level (83.67%) of knowledge of radiation risk from C-arm. A greater percentage of the respondents have an average level of knowledge of radiation protection or safety measures: Surgeons (58.8%), Anesthesiologists (50%), and Theatre Nurses (33.3%). Of this percentage on awareness, only 41.1% of Surgeons, 30% of Anesthesiologists, 16.6% of theatre Nurses adhere to these radiation protection/safety measures. This study further reveals a low level of awareness and use of radiation monitoring devices: Surgeons (29.4%), Anesthesiologists (10%), and Theatre Nurses (8.3%). Also, the study shows that the surgical team spends long periods during surgical procedures: 4 hours (24.48%), 6 hours (20.4%), 12 hours (6.12%), thus increasing their susceptibility to radiation effects. The study further affirms that a lesser percentage of the respondents (44.89%) knew the safest positioning of the radiation-emitting tube, meaning that a greater percentage of the respondents don’t know the safest position to take during beam-on periods. Conclusion: This study shows a high level of knowledge of radiation risk, an average level of awareness to radiation protection/safety measures and a poor level adherence of these measures by the theater team.

AbstractIntroductionSolar ultraviolet radiation (UVR) exposure places outdoor workers at risk of skin cancer and exposure is difficult to control. In response, the Sun Safety at Work Canada (SSAWC) project was undertaken (2014–2016). The purpose of this substudy was to characterize the UVR exposure levels of outdoor workers in the SSAWC project.MethodsThirteen workplaces in the provinces of British Columbia, Ontario, and Nova Scotia participated in an exposure monitoring campaign (late summer/early fall 2016). Study participants were workers from power utilities and municipalities. Participants wore a UVR measurement badge (light-sensitive polysulfone plastic) on their wrist, shoulder, or hardhat. Badge calibration and absorbance measurements were performed in the AusSun Research Lab. Personal UVR doses are presented as standard erythemal doses (SED) and compared with the internationally recommended exposure limit (1.3 SED), as well as to the total available UVR by date. Generalized linear models were used to examine determinants of solar UVR for personal UVR dose (for both SED and percent of ambient UVR). Models considered badge placement, date, province, industry, main job task, and the hours spent outdoors.ResultsMean personal UVR dose of participating workers was 6.1 SED (nearly 5× the recommended limit). Just 14% of workers experienced ‘acceptable’ levels of solar radiation; 10% were exposed at >10 times the limit. In univariate analyses, workers in Ontario had the highest levels (mean 7.3 SED), but even in the lowest exposed province (British Columbia), the mean personal UVR dose was 4.5 SED. Utility workers had double the exposure of municipal workers (10.4 and 5.5 SED, respectively). In the determinants of exposure models, the differences by province were muted, but utility line workers and those in general maintenance had higher predicted exposures. Those who wore their badge on their hardhat also had higher values of SED in the fully adjusted determinants models.ConclusionsSolar ultraviolet overexposure among outdoor workers is a concern, even in a country like Canada with relatively low ambient UVR. Implementation of sun safety programs should be supported in an effort to reduce exposure in this vulnerable group of workers.

In order to protect the human body, developing ultraviolet protection fabric to avoid excessive ultraviolet radiation. The main factors influencing the solar ultraviolet radiation protective properties of anti-ultraviolet fabric are: the type of fiber, yarn properties, fabric structure parameters and fabric color, etc. In order to development anti-ultraviolet protective fabric, we change three parameters of fabric that is the color of textile fabrics, warp density and fabric structure. The yarn selected in the experiment is blended yarn of bamboo charcoal fiber/silk/tencel 30/30/40, and the color of the yarn is gray or black. The sodium copper chlorophyll of bamboo fiber is safety, excellent ultraviolet absorbent; the fabric warp density is designed for 240/10cm, 260/10cm, 280/10cm; fabric structure is designed for three kinds of weave, which is plain weave, compound twill and reinforced satin. Using YG(B)912E tester test the ultraviolet protection performance of the designed fabric specimen, recording its T(UVA) , T(UVB) and UPF. By the repeated orthogonal experiment method, determine which factor is significant to the performance of fabric with ultraviolet protection, and determine the optimal design scheme.

Abstract UV solar radiation are essential for living here on earth, however, at extreme levels, it becomes harmful to all organism with negative effects on humans due to UV-A and UV-B penetrating the earth’s surface. UV radiation index was analyzed over Nigeria, using ten years daily data extracted from the archive of the Ozone Monitoring Instrument (OMI) on-board the EOS Aura spacecraft at a coordinate of 9.08° N, 9. 67° E. The result showed that solar UV radiation is at its peak at local noon time from January 2010 to December 2019. The peak value was observed in the month of November, December, January, February, and March. Hence, the study revealed that the ultraviolet index over Nigeria's varies from high to extreme (i.e., from the Southern to the Northern regions). In conclusion, our findings will create an awareness on those regions with extreme UV radiation and measures such as using sun glasses, umbrellas and putting on protective clothes against the harmful effect of UV radiation.

Pandemic SARS CoV-2 is currently spreading around the world. Preventive measures to be implemented include using Personal Protective Equipment (PPE) especially mask which lead to a lack of mask supply. Strategy is proposed by decontaminating it so that it can be used repeatedly. This research was conducted to compare the effectiveness of UV radiation disinfection in different duration on the KN95 mask. This research was conducted by decontaminating of KN95 mask using UV radiation with radiation time of 15, 30, and 45 minutes. The mask was swab before and after the radiation. Examination for the growth of pathogen bacterial colonies and total plate count method was done to determine the effectivity. It was found the number of germs before and after has decreased significantly radiation at 30 (P = 0.036) and 45 minutes (P = 0.037). It also can be effective in decontaminating pathogen bacterial as the number colony of Staphylococcus aureus has decreased significantly in 30 minutes (P=0.034) and 45 minutes exposure (P= 0.037). The results of this study indicate that UV radiation for 30 and 45 minutes can be effective in decontaminating pathogen bacterial

The Covid-19 pandemic has spread across the world during early 2020, with unforeseen consequences. Beyond social measures and biomedical research, it is important to assess the seasonality of the epidemic to inform strategies, with limited available data in the short period of time between the March equinox and the June solstice. While the effect of multiple factors is being investigated, little attention has been paid to ultraviolet (UV) radiation, a key parameter of seasonal forcing. We review the effects of UV radiation, proposing it as a potential element of seasonality, and provide evidence from the current literature and scant, yet revealing, observations. Explicit consideration should be given to UV radiation for the seasonality of Covid-19 at high latitudes and altitudes, based on the SARS and MERS epidemics and coronavirus diseases, and not just the ‘warmer days’ of summer.

The global increase in mobile phone (MP) usage in proximity to the human-body and proliferation of base stations has created potential health concerns about exposure to radiation emitted from these devices. This study aims to identify students who are knowledgeable about radiation emitted from MPs, assess their degree of awareness of the potential health risks from MP usage, and suggest precautionary and safety measures that can reduce or eliminate the health hazards of MP radiation. We prospectively evaluated medical students' knowledge of MP-emitted radiation, potential health risks, precautionary and safety measures at Benue State University (BSU), Makurdi, between May 13th and July 12th, 2022. Data was obtained through a well-structured questionnaire, analyzed using the Statistical Package for Social Sciences (SPSS) version 23 with a p value<0.05. Results were presented in tables and figures. The study included 147 fourth-sixth year medical students, aged 20-38 years, male: female ratio 3:1, and mean age of 26.5±3.4. Knowledge of radiation emitted from MPs was high, 134(91.2%), especially among final year students. Similarly, 93 (63.3%) students were aware of potential health risks associated with MP usage, with some evidently experiencing the negative consequences. Many students ignored precautionary measures and continued making long phone-conversations 80(54.4%), putting MPs in their pockets 92(62.6%) and at their bed-head 77(52.4%), prompting crucial safety measures. Knowledge of radiation emitted by MPs was outstanding, with considerable awareness of potential health risks from MP usage. Important safety measures were proposed, even though the precautionary measures to minimize these risks were largely ignored.

Greenhouse workers, despite being in a space beneath a plastic cover, may be susceptible to risks associated to ultraviolet (UV) radiation in skin and eyes. The present work focuses on experimentally analysing this risk throughout a complete year. For this purpose, a network of sensors has been designed, comprising 12 UV radiation measuring stations inside the greenhouse and one outside. It is shown that the UVI risk limit established by World Health Organization (WHO) is exceeded for some particular dates and times, thus there exist risk of damage caused by UV radiation for greenhouse workers. The results allow to identify the UV risk periods for the location studied. A diagram called “UVIgram” has been created which offers weather and UV radiation information for a particular location, for each month, and also in general for the whole year. Finally, a series of recommendations and protection measures are given, highlighting the whitening of the plastic cover of the greenhouse and an alarm system which has been designed to alert workers when UV risk exists.

Purpose. To substantiate the efficacy and safety of scleral collagen cross-linking with riboflavin and ultraviolet radiation. Material and methods. The study was conducted on cadaver porcine eyes and rabbit eyes. Results. It has been experimentally proven that crosslinking with riboflavin / ultraviolet A leads to an increase in the biomechanical strength of the scleral tissue, changing its structure and leading to an increase in the packing density of collagen fibers and an increase in the diameter of collagen fibrils, which confirms the formation of additional cross-links between scleral macromolecules. The absence of any pathological changes in the fibers of the fibrous membrane of the eye was established. The permeability of scleral tissue for ultraviolet radiation of the A range was determined. Based on the data obtained, a formula was proposed for calculating the threshold value of the intensity of ultraviolet radiation during the SCXL procedure. Using the methods of light microscopy, electroretinography and optical coherence tomography, it was revealed that SCXL with riboflavin / ultraviolet A under the studied parameters is safe for the structures of the eye (cornea, retina and optic nerve). A gentle technology for photopolymerization of the sclera with the use of the “UFalink S” device has been developed, the advantage of which is the ability to carry out ultraviolet irradiation in hard-to-reach areas of the eyeball. At the same time, an effective increase in the biomechanical strength characteristics of the scleral tissue was proved and the absence of a damaging effect on the structures of the eye was demonstrated. Conclusion. A clinical study of the scleral crosslinking procedure with riboflavin / ultraviolet A with the proposed parameters: irradiance of 3 mW / cm², irradiation time 30 minutes and preliminary saturation of the sclera with 0.1% aqueous solution of riboflavin for 20 minutes, which in experiments have shown their effectiveness and safety, is recommended. During the procedure, it is recommended to use a water-based photosensitizer riboflavin, without the addition of dextran, which leads to dehydration of the sclera and an increase in its permeability to ultraviolet light, which increases the risk of damage to the inner layers of the eye. Key words: scleral crosslinking, ultraviolet A, riboflavin, experiment, myopia.

Background: The frequency of radiological investigations increases to many fold now-a-days, so it is necessary to know the knowledge of all physicians about radiation dose, safety measures and regulations which governs the use and practice of radiation examination and their therapeutic use. The objectives comprise to investigate amongst all Physicians: (1) level of knowledge and awareness of radiation dose of radiological investigations and radiobiology of radiation exposure, and (2) to assess physicians’ knowledge about the risks associated with the use of radiological examinations and their safety measures.Methods: A questionnaire targeting about knowledge, safety measures, and radiation biology about some commonly performed radiological procedures was addressed: (1) Relative radiation doses, (2) Associated risks of radiation exposure, (3) What safety measures should be considered before examination. (4) What risk and hazards all physicians considered when requesting radiological examinations.Results: A questionnaire answered by physicians demonstrates loops in knowledge. In all, 15% (14/92) incorrectly believed that magnetic resonance imaging involved radiation exposure and 3% (3/92) incorrectly believed that ultrasound involved radiation exposure; 38% (35/92) stated that they always explain the benefits and risk of radiation to their patients when obtaining informed consent for examinations involving radiation.Conclusions: This study concluded a deficit of knowledge about radiation dose exposure, and hazards among Physicians, which may cause them to request more radiological investigations than appropriate and high-dose investigations instead of lower dose alternatives. Providing better radiation protection training may help improve their basic knowledge on the subject and reduce unnecessary patient exposure to radiation.

Traditional heat treatment methods are an integral part of the dairy industry. However, non-thermal methods ensure microbiological safety while preserving nutritional value of the dairy product, as well as improving its technological properties. The article reviews scientific and technical publications on ultraviolet (UV) treatment and its effect on the structure and properties of milk proteins and technological indicators of dairy products. The review includes English and Russian articles published in Scopus, Web of Science, Elsevier, ResearchGate, and Elibrary databases in 2004–2021. Most publications focus on maintaining the microbiological safety of milk and dairy products. Depending on the radiation dose, UV treatment was reported to cause denaturation and aggregation of milk proteins, followed by new cross-links. Conformational changes improve the functional properties of milk proteins, which makes them valuable food ingredients of film coatings and fermented milk products. Electromagnetic treatment polymerizes whey proteins. This property can be used to produce strong film coatings with low vapor permeability. In fermented milk production, UV radiation improves such technological properties of yogurt as viscosity and water-holding capacity. The effect of electromagnetic waves on animal proteins and dairy products remains an understudied area of advanced research.