Dissertations / Theses on the topic 'Ultrasound beam'

Estimation of mean spatial blood velocity, and hence volumetric flow, using Doppler ultrasound is typically performed under the assumption that the beam samples each part of the cross section of the blood vessel equally. This allows the mean velocity to be regarded as being proportional to the conventional mean Doppler shift frequency. In this work a new frequency estimator of mean velocity is presented for the case where the beam is assumed to be of negligible width compared to the vessel diameter and directed through the vessel axis. This estimator is proportional to the mean velocity if it can be further assumed that the velocity profile is axi-symmetric and is monotonic, or has an idealised bidirectional form. In practice neither the assumption of a uniformly insonating beam nor the assumption of an infinitely narrow beam are valid. Also the Doppler spectrum, as a representation of the velocity distribution of blood cells, is corrupted by spectral broadening, noise, filtering and the stochastic nature of the signal. In addition difficulty exists in the measurement of the representative Doppler angle. The effects on both estimators of these potential sources of error are discussed and compared. The question of volumetric flow measurement at various arterial sites is addressed by modelling the velocity profiles in the vessel throughout the cardiac cycle. Some sources of error affect only the new estimator, so one conclusion drawn is that mean velocity estimation and volumetric flow measurement are better performed using the conventional frequency with a uniformly insonating beam. Nevertheless if the beam is more accurately described as being very narrow and centrally positioned the new estimator performs better than the conventional frequency estimator. This description may well be appropriate if the blood vessels are large and the Doppler beam is transmitted and received using a linear array transducer such as in modern duplex systems.

The aim of this study was to characterize the interaction between a pulsed ultrasonic wave and a paper forming screen for potential development of a smart paper forming sensor to measure velocity profile of the forming jet as it impinges on the wire. To achieve this goal, a Signal-Processing DOP 2000 pulsed ultrasonic Doppler velocimeter was used to generate a pulsed ultrasonic signal. The signal was transmitted and received using four different ultrasonic transducers: a 2 MHz 10 mm, 4 MHz 5 mm, 4MHz 8 mm focused, and 8 MHz 5 mm. The ultrasonic signals were then analyzed in order to determine the ultrasonic beam echo amplitude and shape. These tests were performed with and without various paper forming screens placed between the ultrasonic transducer and an ultrasonic signal target. Two different paper forming screens were utilized to study the interaction of the ultrasonic beam with the forming screens. The tests showed that the ultrasonic signal passing through the forming screens is greatly attenuated causing a sharp decrease in echo amplitude. To overcome the attenuation of the signal, a much higher amplification of the signal was used causing an increase in the saturation region around the forming screen. This increased the minimum distance that a target had to be away from the forming screen. The closest distance from the plastic sphere to the screen over the widest range of transducer-screen-distances that produced detectable echoes was achieved with the 4 MHz 5 mm transducer. The tests showed for both screens that there is more variation in beam width when the screen is moved laterally than when it is not moved at all. They also show that even though the pores in the forming screen are very small, they seem to have a great effect on the beam width measurements of the ultrasonic transducer.

The work deals with methods of measuring the parameters of the ultrasonic beam generated by piezoelectric sensors. The theoretical part contains a literature search of methods for the analysis of the ultrasonic beam generated by piezoelectric transducers with dimensions of units of millimeters. The problematics of measurement using piezoelectric or optical fiber hydrophones is investigated in more detail. The scope of the practical part of the work is the design and implementation of measuring equipment that allows spatial analysis of the beam during propagation by a complicated signal path, for automotive level and concentration sensors of the company Vitesco Technologies s.r.o. The system uses a hydrophone method to measure the ultrasonic beam. Due to test measurements, the repeatability of the measured results is confirmed, the results are discussed in the end.

Biological effects and prostate motion were studied for prostate cancer patients treated with external beam radiotherapy. The prostate motion was determined using an ultrasound-based patient positioning system (BAT: B-mode Acquisition and Targeting) just after conventional patient setup. The changes in planned biological effects due to prostate motion were calculated for the prostate target organ and for the rectum and bladder normal tissues using TCP (tumor control probability) and NTCP (normal tissue complication probability) calculations, respectively. The prostate TCP calculations were carried out for both prostate PTV and GTV structures, whereas the rectum and bladder wall structures were used for the NTCP calculations.

Thesis (MTech (Electrical Engineering))--Cape Peninsula University of Technology.
Pulsed Ultrasound Velocimetry combined with Pressure Difference (PUV+PD) measurement is a non-invasive in-line rheometric technique which is used to analyse the complex flow properties of industrial fluids for quality control purposes. Cape Peninsula University of Technology (CPUT) and Technical Research Institute of Sweden (SP) have developed and patented a new PUV+PD based system, called Flow-Viz™. Despite this advancement, the system and ultrasound sensor technology have not been fully tested and evaluated in a wide range of industrial fluids. Acoustic characterisation tests were carried out at SP, with the aim of understanding the ultrasound beam properties after propagating through industrial stainless steel (316L) pipe walls. For these tests, a high-precision robotic XYZ-scanner and needle hydrophone setup were used. Different ultrasound sensor configurations were mounted to a stainless steel pipe while using different coupling media between the transducer-to-wedge and sensor wedge-to-pipe boundaries. The ultrasound beam propagation after the wall interface was measured by navigating the needle hydrophone within a predefined 2-dimensional spatial grid. The most suitable coupling material was determined from the acoustic characterisation, and then used in the in-line rheological characterisation tests to evaluate the performance of the Flow-VizTM rheometric unit against conventional tube viscometry. The in-line rheological tests were conducted with bentonite, kaolin and Carboxymethyl cellulose (CMC) model fluids. The flow loop used consisted of three different pipe test sections; and two concentrations of each fluid were tested in order to ascertain the consistency of the measurements. The in-line rheological tests showed good agreement (±15%) between the two techniques and Flow-VizTM was able to provide important data at very low shear rates. Acoustic characterisation indicated that variations in the beam properties were highly dependent on the acoustic couplants used to mount the sensors to the stainless steel pipes. Furthermore, the in-line results showed the effectiveness of Flow-VizTM as an industrial rheometer. The non-invasive ultrasound sensor technology, was for the first time acoustically characterised through stainless steel. This information will now be used to further optimise the unique technology for advanced industrial applications, e.g. oil drilling fields, complex cement grout and food processing applications.

The contents of this thesis consider new methods for generating ultrasound beams for enhanced image quality in medical imaging. The results presented are produced through computer simulations. The thesis consists of an introductory chapter and four papers, which are all intended to be individually readable. Chapter 1 gives a brief overview of ultrasound and medical ultrasound imaging, as well as different aspects of ultrasound image quality and acoustic noise. A non-linear wave equation is presented and analyzed. This equation describes ultrasound propagation within, and interaction with tissue. In Paper A, a transducer annular array design method is presented. The method involves a geometric pre-focusing, which may vary between the array elements. This is useful for producing narrow receive beams within a large imaging depth window. It is advantageous for avoiding problems that occur when combining high frequencies and large receive apertures when utilizing the conventional equal-area design method. Paper B introduces a method to produce synthetic transmit beams that are useful for suppression of reverberation noise caused by multiple scattering of the forward-propagating imaging pulse. This is done through combination of two transmit pulse complexes denoted Second order UltRasound Field (SURF). Each such complex consists of a conventional high-frequency imaging pulse added to a low-frequency sound-speed manipulation pulse. The SURF transmit beam is generated by forming the difference between the propagated fields, filtered around the imaging frequency. This beam has suppressed amplitude near the transducer, where a reflection-generating body-wall is often present during in vivo imaging. Furthermore, a method to produce a combined second-harmonic pulse inversion (PI) and SURF beam is also presented, here denoted SURF-PI. Two imaging setups are defined for which the feasibility of the method is tested through simulations in case of propagation through homogeneous tissue. SURF beams and combined SURF-PI beams are compared to fundamental imaging and PI imaging beams for the two setups. The SURF-PI beams are the most suppressed in the near-field, followed by the approximately equally suppressed SURF and PI beams. The signal level within the imaging depth region becomes higher for SURF than for PI. In Paper C, two signal processing methods for further adjustment of the SURF beams are introduced. This is achieved through post-processing, either by application of a time-shift, or of a general filter, to one of the propagated fields. The processing is done prior to carrying out the subtraction that is done to form the SURF beam. This provides a flexible way of adjustment to choose the depth position where the scattering sources wished to be suppressed are located. Different adjustments may be realized without need for re-transmission or resumed propagation of the SURF pulse complexes. The post-processing methods are applied to a dataset generated for Paper B. Adjusted transmit beam examples are presented and their reverberation suppression abilities are compared to non-adjusted SURF. In Paper D, the feasibility study of the SURF beam generation as presented in Paper B, and its post-processing adjustment as presented in Paper C, are enlarged to include propagation within an inhomogeneous medium where a body-wall model producing severe aberration delays is present. It is shown that both the generation of the SURF beams and the post-processing adjustment are attainable under the modeled conditions.
artikle I: "This work has been submitted to the IEEE for possible publication. Copyright may be transferred without notice, after which this version may no longer be accessible."

Dans le cadre des recherches menées sur les SFR (Sodium cooled Fast Reactor), le CEA souhaite développer une instrumentation innovante et spécifique à ces réacteurs. Le travail présenté concerne la mesure par ultrasons, de la température du sodium à la sortie des têtes des assemblages du coeur du réacteur. Cette instrumentation implique la propagation d'ultrasons dans du sodium liquide, thermiquement inhomogène et turbulent. Le milieu provoque des déviations du faisceau acoustique qu'il faut prévoir et quantifier pour envisager d'employer les ultrasons comme moyen de mesure dans un coeur de réacteur SFR.Pour cela un code nommé AcRaLiS (Acoustic Ray in Liquid Sodium) a été implémenté. Une étude thermo-hydraulique précise du sodium a tout d'abord été menée afin de proposer une description adaptée du milieu et de choisir le modèle de propagation acoustique adéquat. Puis une implémentation a été réalisée afin de permettre la simulation rapide de la propagation d'ondes de plusieurs mégahertz dans ce milieu particulier. Ce code prévoit les déviations et l'évolution de l'intensité du faisceau acoustique. Deux expériences ont ensuite été conçues et réalisées pour vérifier ce code. La première, nommée UPSilon, innove en remplaçant le sodium par de l'huile de silicone afin d'avoir une inhomogénéité thermique stable pendant l'expérience. Elle permet de déterminer la validité du code AcRaLiS dans des inhomogénéités thermiques. La seconde, nommée IKHAR, permet d'étudier en eau l'influence de la turbulence sur la propagation d'ondes, en exploitant les instabilités de Kelvin-Helmholtz. Les conclusions et les perspectives sont présentées en élargissant à d'autres domaines d'application
In the frame of research on Sodium cooled Fast nuclear Reactor (SFR), CEA aims to develop an innovative instrumentation, specific to these reactors. The present work relates to the measurement of the sodium temperature at the outlet of the assemblies of the reactor's core by an ultrasonic method. This instrumentation involves the propagation of ultrasonic waves in liquid sodium, thermally inhomogeneous and turbulent. Environment causes deviations of the acoustic beam that must be understood to predict and quantify to consider ultrasound as a measure means in a core of SFR reactor. To determine the magnitude of these influences, a code named AcRaLiS (Acoustic Ray in Liquid Sodium) has been implemented. In a first step, a thermal-hydraulic study specific to the medium, was conducted to provide an adequate description of the environment and choose a suitable acoustic propagation model. Then an implementation has been performed to allow rapid simulations of the wave propagation at several megahertz in this particular environment. This code provides ultrasounds deviations and changes in beam intensity.Two experiments were designed and conducted to verify the code. The first, named UPSilon innovates by replacing sodium by silicone oil in order to have a stable thermal inhomogeneity during the experiment. It allows to determine the validity of the code AcRaLiS with thermal inhomogeneities. The second, called IKHAR allows to study the influence of water turbulence on the propagation of waves, using the Kelvin-Helmholtz instabilities. Conclusions and perspectives are presented, including perspectives for other application domains

[ES] La capacidad de controlar y modificar los haces de energía ha sido motivo de investigación por parte de la comunidad científica desde largo tiempo atrás. En el campo de la acústica, este control energético de las ondas mecánicas tiene numerosas aplicaciones. Desde las aplicaciones industriales, alimentarias, farmacéuticas, etcétera hasta la biomedicina. Esta tesis se basa en la aplicación del control y modulación focal de los ultrasonidos para el uso en este último campo. Se puede modular y controlar los focos de ultrasonidos de diferentes formas. En este caso, se han desarrollado lentes planas que utilizan el principio de la difracción para lograr focalizar los haces. Las ventajas del uso de lentes planas de focalización permiten ser implementadas de forma sencilla en procesos de mecanización e incluso mediante impresión 3D. Se propone utilizar transductores planos que al emitir sobre una lente acústica, se produzca una conformación focal de características controladas. La lente conocida como lente de Fresnel (FZP) ha sido escogida como base de diseño en la implementación de las diferentes soluciones que logran cumplir con los objetivos marcados. Mediante la aplicación de modificaciones en una FZP se puede lograr pasar de una lente con capacidades extraordinarias de focalización a una lente capaz de controlar la resolución lateral y la profundidad de foco e incluso mejorar la ganancia. El objetivo final de aplicación es el uso en transductores de ultrasonidos de alta intensidad conocidos como HIFU. Mejorar la capacidad de resolución hace que se puedan desarrollar mejores terapias oncológicas que supongan un índice mayor de éxito en la lucha contra el cáncer. En la presente tesis se ha propuesto, además, una novedosa lente FZP basada en el cambio de fase que puede resultar un antes y un después en aplicaciones biomédicas. Se ha conseguido no solo mejorar la eficiencia de una FZP, sino que se ha conseguido implementar en materiales compatibles con resonancia magnética. Se han desarrollado modelos numéricos basados en el método de los elementos finitos que emulan la física involucrada. Las medidas han sido realizadas en condiciones controladas por un sistema robotizado de alta precisión. Todos los resultados obtenidos y publicados han sido desarrollados de forma numérica y experimental, validándose el método de trabajo y dando consistencia a las soluciones propuestas.
[CA] La capacitat de controlar i modificar els feixos d'energia ha sigut motiu d'investigació per part de la comunitat científica des de llarg temps arrere. En el camp de l'acústica, este control energètic de les ones mecàniques té nombroses aplicacions. Des de les aplicacions industrials, alimentàries, farmacèutiques, etcètera fins la biomedicina. Esta tesi es basa en l'aplicació del control i modulació focal dels ultrasons per a l'ús en este últim camp. Es pot modular i controlar els focus d'ultrasons de diferents formes. En este cas, s'han desenvolupat lents planes que utilitzen el principi de la difracció per a aconseguir focalitzar els feixos. Els avantatges de l'ús de lents planes de focalització permeten ser implementades de forma senzilla en processos de mecanització i inclús per mitjà d'impressió 3D. Es proposa utilitzar transductores plans que a l'emetre sobre una lent acústica, es produïsca una conformació focal de característiques controlades. La lent coneguda com a lent de Fresnel (FZP) ha sigut triada com a base de disseny en la implementació de les diferents solucions que aconseguixen complir amb els objectius marcats. Per mitjà de l'aplicació de modificacions en una FZP es pot aconseguir passar d'una lent amb capacitats extraordinàries de focalització a una lent capaç de controlar la resolució lateral i la profunditat de focus i inclús millorar el guany. L'objectiu final d'aplicació és l'ús en transductores d'ultrasons d'alta intensitat coneguts com HIFU. Millorar la capacitat de resolució fa que es puguen desenvolupar millors teràpies oncològiques que suposen un índex major d'èxit en la lluita contra el càncer. En la present tesi s'ha proposat, a més, una nova lent FZP basada en el canvi de fase que pot resultar un abans i un després en aplicacions biomèdiques. S'ha aconseguit no sols millorar l'eficiència d'una FZP, sinó que s'ha aconseguit implementar en materials compatibles amb ressonància magnètica. S'han desenvolupat models numèrics basats en el mètode dels elements finits que emulen la física involucrada. Les mesures han sigut realitzades en condicions controlades per un sistema robotitzat d'alta precisió. Tots els resultats obtinguts i publicats han sigut desenvolupats de forma numèrica i experimental, validant-se el mètode de treball i donant consistència a les solucions proposades.
[EN] The ability to control and modify energy beams has been the subject of research by the scientific community for a long time. In the acoustic field, this energetic control of mechanical waves has numerous applications. From industrial, food, pharmaceutical applications, et cetera, to biomedicine. This thesis is based on the ultrasound control and focal modulation applications. It is possible to modulate and control the ultrasound focii in different ways. In this case, flat lenses were developed based on the principle of diffraction to focus the beams. The advantages of using flat focusing lenses allow them to be easily implemented in machining and drilling processes and even through 3D printing. It was proposed to use planar transducers that when emitting on an acoustic lens, controlled characteristics of focal conformation were produced. The lens known as Fresnel Zone Plane (FZP) was chosen as the implementation design basis for the different solutions that manage to fulfill the objectives set. By applying modifications to an FZP it was possible to go from a lens with extraordinary focusing capabilities to a lens that was capable to control lateral resolution, depth of focus and even improving the gain. The final objective application was the use in high intensity ultrasound transducers known as HIFU. Improving the ability to resolve makes it possible to develop better cancer therapies that represent a higher rate of success in the fight against cancer. In the present thesis, a novel FZP lens based on phase change has also been proposed that can be a before and after in biomedical applications. It has not only been possible to improve the efficiency of an FZP, but it has also been possible to implement it in materials compatible with magnetic resonance imaging. Numerical models based on the finite element method were developed for emulating the involved physics. Measurements were carried out under controlled conditions by a high precision robotic system. All the results obtained and published were developed numerically and experimentally, validating the working method and giving consistency to the proposed solutions.
I want to acknowledge the following public funding sources that have made possible this research: Grant BES-2016-077133 (Ministerio de Ciencia, Innovación y Universidades de España) Project TEC2015-70939-R (MINECO/FEDER). Tomsk Polytechnic University within the framework of Tomsk Polytechnic University Competitiveness Enhancement Program.
Tarrazó Serrano, D. (2020). Design, modelling, characterization and implementation of acoustic lenses for modulation of ultrasound beams [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/159895
TESIS

Gegenstand und Ziel: Einsatz des Ultraschallkontrastmittels SonoVue® zur Ermittlung der Hepatischen Transitzeit bei lebergesunden Hunden. Material und Methoden: Untersucht wurden 45 lebergesunde Hunde aus dem Patientengut der Klinik für Kleintiere der Universität Leipzig. Ausschlusskriterien waren Leber- und Herz-Kreislauferkrankungen, sowie Tumorleiden. Die Kontrastmitteluntersuchungen erfolgten am narkotisierten Tier. Das Kontrastmittel wurde intravenös appliziert. Die Zeitdifferenz zwischen Ankunft in den Leberarterien bis zum Erreichen der Lebervenen wird als Hepatische Transitzeit definiert. Die Auswertung erfolgte von zwei unabhängigen Betracht-ern, sowie einer im Ultraschallgerät installierten Analysesoftware (TIC; Time-intensity-curve). Erfasst wurden zusätzlich von jedem Patienten die Blutflussgeschwindigkeiten in der Aorta abdominalis und den Lebervenen vor und nach der Kontrastmitteluntersuchung. Ebenfalls sind die Ankunftszeiten des Kontrastmittels in den Leberarterien und Lebervenen ermittelt worden. Diese Daten wurden mit den Angaben des Alters, dem Geschlecht und dem Gewicht verglichen. Die ermittelten Ankunftszeiten des Kontrastmittels wurden mit den Blutflussgeschwindigkeiten des jeweiligen Patienten korreliert. Ergebnisse: Die Hepatische Transitzeit des Kontrastmittels SonoVue® für lebergesunde Hunde beträgt 9,82 s. Schlussfolgerungen: Die Hepatische Transitzeit des Signalverstärkers SonoVue® beim lebergesunden Hund liegt bei 9,82 s und ist damit ca. eine Sekunde kürzer als beim Men-schen. In anschließenden Studien muss bei Hunden mit nachgewiesenen Lebermetastasen die Hepatische Transitzeit ermittelt werden. Entsprechen die Ergebnisse denen aus der Human-medizin, so ist mit einer Verkürzung der Hepatischen Transitzeit zu rechnen. Insbesondere bei bekanten Primärtumor könnte mit dieser Methode eine Metastasierung früher erkannt werden.

Les sondeurs multifaisceaux sont des appareils qui permettent d’effectuer des mesures de profondeurs bathymétriques. Le principe consiste à émettre une onde acoustique vers le fond marin, une fois réfléchie, elle est réécoutée par le sondeur. Le temps de trajet aller/retour et la vitesse du son dans les milieux marins sont utilisés pour déterminer les profondeurs marines. Les systèmes de mesure sont généralement constitués d’un système GNSS pour connaitre la position de la plateforme de mesure, d’une centrale inertielle pour déterminer les mouvements d’attitude et d’un sondeur proprement dit. La fusion des données de ces différents appareils permet d’avoir des mesures de sondes géoréférencées dans un repère global. Pour améliorer la qualité du résultat du traitement relatif à la mise en commun des données, communément appelée géoréférencement, les alignements géométriques et une synchronisation temporelle doivent être effectués entre les appareils du système de mesure. Ces opérations sont dénommées calibration. Il existe trois principaux paramètres à déterminer durant ce processus de calibration : la latence entre les horloges des capteurs utilisés (GNSS, centraleinertielle et sondeur), les bras de levier entre le centre acoustique du sondeur et le point de référence de positionnement et le troisième principal paramètre est le désalignement angulaire entre les repères de référence du sondeur et de la centrale inertielle. Cette thèse propose de nouvelles méthodes qui permettent d’estimer ces paramètres. À la différence des méthodes de calibration existantes dites traditionnelles, les méthodes proposées sont automatiques, rigoureuses et ne sont pas subjectives
Multi-beam echo sounders are devices which are used to compute the bathymetric depth. The principle consists in sending to the seabed an acoustic signal, then this signal is reflected and received by the sounder which records the two-way travel time. This two-way travel time combined with the speed of sound are used to derive the depth. Measurement systems are generally constituted of a GNSS which gives the survey platform position, an Inertial measurement unit which gives the orientation and a sounder itself. The data merge of these different sensors enables to have the georeferenced soundings in a global frame. For improving the quality of process pertaining to the merging of data, what is commonly termed georeferencing, geometrical alignment and a temporal synchronization have to be performed between devices of the measurement system. These operations are referred to as calibration. There exist three main parameters to determineduring this process of calibration: the latency between the reference time-tag clocks of each used sensor (GNSS, inertial measurement unit, sounder), the lever arms between the sounder acoustic center and the positioning reference point of the survey platform, and the third principal parameter is the angular misalignment between the sounder and the inertial unit reference frames. This thesis proposes new methods for the estimation of these parameters. In contrast toexisting methods of calibration, referred to as traditional, the proposed methods are automatic, rigorous and do not depend on the user

[EN] Nature is nonlinear. The linear description of physical phenomena is useful for explain observations with the simplest mathematical models, but they are only accurate for a limited range of input values. In the case of intense acoustics waves, linear models obviate a wide range of physical phenomena that are necessary for accurately describe such high-amplitude waves, indispensable for explain other exotic acoustic waves and mandatory for developing new applied techniques based on nonlinear processes. In this Thesis we study the interactions between nonlinearity and other basic wave phenomena such as non-classical attenuation, anisotropic dispersion and periodicity, and diffraction in specific configurations. First, we present intense strain waves in a chain of cations coupled by realistic interatomic potentials. Here, the nonlinear ionic interactions and lattice dispersion lead to the formation of supersonic kinks. These intrinsically-nonlinear localized dislocations travel long distances without changing its properties and explain the formation of dark traces in mica crystals. Then, we analyze nonlinear wave processes in a system composed of multilayered acoustic media. The rich nonlinear dynamics of this system is characterized by its strong dispersion. Here, harmonic generation processes and the relation with its band structure are presented, showing that the nonlinear processes can be enhanced, strongly minimized or simply modified by tuning the layer parameters. In this way, we show how the dynamics of intense monochromatic waves and acoustic solitons can be controlled by artificial layered materials. In a second part, we include diffraction and analyze four types of singular beams. First, we study nonlinear beams in two dimensional sonic crystals. In this system, the inclusion of anisotropic dispersion is tuned for obtain simultaneous self-collimation for fundamental and second harmonic beams. The conditions for optimal second harmonic generation are presented. Secondly, we present limited diffraction beam generation using equispaced axisymmetric diffraction gratings. The obtained beams are truncated version of zero-th order Bessel beams. Third, the grating spacing can be modified to achieve focusing, where the generated nonlinear beams presents high gain, around 30 dB, with a focal width which is between the diffraction limit and the sub-wavelength regime, but with its characteristic high amplitude side lobes strongly reduced. Finally, we observe that waves diffracted by spiral-shaped gratings generate high-order Bessel beams, conforming nonlinear acoustic vortex. The conditions to obtain arbitrary-order Bessel beams by these passive elements are presented. Finally, the interplay of nonlinearity and attenuation in biological media is studied in the context of medical ultrasound. First, a numerical method is developed. The method solves the constitutive relations for nonlinear acoustics and the frequency power law attenuation of biological media is modeled as a sum of relaxation processes. A new technique for reducing numerical dispersion based on artificial relaxation is included. Second, this method is used to study the harmonic balance as a function of the power law, showing the role of weak dispersion and its impact on the efficiency of the harmonic generation in soft-tissues. Finally, the study concerns the nonlinear behavior of acoustic radiation forces in frequency power law attenuation media. We present how the interplay between nonlinearity and the specific frequency power law of biological media can modify the value for acoustic radiation forces. The relation of the nonlinear acoustic radiation force with thermal effects are also discussed. The broad range of nonlinear processes analyzed in this Thesis contributes to understanding the behavior of intense acoustic waves traveling trough complex media, while its implications for enhancing existent applied acoustics techniques are presented.
[ES] La Naturaleza es no lineal. La descripción lineal de los fenómenos físicos es de gran utilidad para explicar nuestras observaciones con modelos matemáticos simples, pero éstos sólo son precisos en un limitado rango de validez. En el caso de onda acústica de alta intensidad, los modelos lineales obvian un amplio rango de fenómenos físicos que son necesarios para describir con precisión las ondas de gran amplitud, pero además son necesarios para explicar otros procesos más exóticos e indispensables para desarrollar nuevas aplicaciones basadas en propagación no lineal. En esta Tesis, estudiamos las interacciones entre no linealidad y otros procesos complejos como atenuación no-clásica, dispersión anisotrópica y periodicidad, y difracción en configuraciones específicas. En primer lugar, presentamos ondas de deformación en una cadena de cationes acoplados por potenciales realísticas. Aquí, las interacciones no lineales entre iones, producen la conformación de kinks supersónicos. Estas dislocaciones localizadas intrínsecamente no lineales viajan por la red largas distancias sin variar sus propiedades, y pueden explicar la formación de trazas en minerales como la mica. Aumentando la escala del problema, estudiamos los procesos acústicos no lineales en medios multicapa. La rica dinámica de estos medios está caracterizada por la fuerte dispersión debido a la periodicidad del sistema. Aquí, estudiamos los procesos de generación de harmónicos, mostrando como modificando la estructura podemos potenciar, minimizar, o simplemente modificar artificialmente la transferencia de energía entre las componentes espectrales, y de esta manera controlar la dinámica de las ondas y solitones en el interior de la estructura. En la segunda parte, incluimos difracción y analizamos cuatro tipos de haces singulares. En primer lugar, analizamos haces ultrasónicos no lineales en cristales de sonido bidimensionales. En este sistema, las propiedades de anisotropía del medio son ajustadas para obtener la auto-colimación simultánea del primer y segundo harmónico. Así, se obtiene la propagación no difractiva para las dos componentes. En segundo lugar, presentamos haces de difracción limitada empleando rejillas de difracción axisimétricas. Por último, demostramos la generación de haces de Bessel de orden superior mediante estructuras en espiral. En la última parte, estudiamos la competición entre no linealidad y la atenuación y dispersión observable en medios biológicos en el contexto de las aplicaciones de biomédicas de los ultrasonidos. En primer lugar desarrollamos un nuevo método computacional para la dependencia frecuencial en forma de ley de potencia de la absorción característica de los tejidos. Este método en dominio temporal es usado posteriormente para revisar los procesos básicos no lineales prestando especial interés en el paper de la dispersión del tejido. Por último, la resolución de las ecuaciones constitutivas nos permite abordar la descripción no lineal de la fuerza de radiación acústica producida en tejidos biológicos, y las implicaciones existentes con la deposición de energía y transferencia de momento para ondas ultrasónicas de alta intensidad. El amplio abanico de procesos no lineales analizados en esta tesis contribuye a una mejor comprensión de la dinámica de las ondas acústicas de alta intensidad en medios complejos, donde las implicaciones existentes en cuanto a la mejora de sus aplicaciones prácticas son puestas de manifiesto.
[CAT] La Naturalesa és no lineal. La descripció lineal dels fenòmens físics és de gran utilitat per a explicar les nostres observacions amb models matemàtics simples, però aquests sol són precisos en un limitat rang de validesa. En el cas d'ona acústica d'alta intensitat, els models lineals obvien un ampli rang de fenòmens físics que són necessaris per a descriure amb precisió les ones de gran amplitud, però a més són necessaris per a explicar altres processos més exòtics i indispensables per a desenvolupar noves aplicacions basades en propagació no lineal. En aquesta Tesi, estudiem les interaccions entre no-linealitat i altres processos complexos com atenuació no-clàssica, dispersió anisotròpica i periodicitat, i difracció en configuracions específiques. En primer lloc, presentem ones de deformació en una cadena de cations acoblats per potencials realistes. Ací, les interaccions no lineals entre ions, produeixen la conformació de kinks supersònics. Aquestes dislocacions localitzades intrínsecament no lineals viatgen per la xarxa llargues distàncies sense variar les seues propietats, i poden explicar la formació de traces en minerals com la mica. Augmentant l'escala del problema, estudiem els processos acústics no lineals en mitjans multicapa. La rica dinàmica d'aquests mitjans es caracteritza per la forta dispersió a causa de la periodicitat del sistema. Ací, estudiem els processos de generació d'harmònics, mostrant com modificant l'estructura podem potenciar, minimitzar, o simplement modificar artificialment la transferència d'energia entre les components espectrals, i d'aquesta manera controlar la dinàmica de les ones i solitons a l'interior de l'estructura. En la segona part, incloem difracció i analitzem quatre tipus de feixos singulars. En primer lloc, analitzem feixos ultrasònics no lineals en cristalls de so bidimensionals. En aquest sistema, les propietats d'anisotropia del medi són ajustades per a obtenir l'acte-col·limació simultània del primer i segon harmònic. Així, s'obté la propagació no difractiva per a les dues components. En segon lloc, presentem feixos de difracció limitada emprant reixetes de difracció axisimètriques. Per últim, vam demostrar la generació de feixos de Bessel d'ordre superior mitjançant estructures en espiral. En l'última part, estudiem la competició entre no linealitat i l'atenuació i dispersió observable en medis biològics en el context de les aplicacions biomèdiques dels ultrasons. En primer lloc desenvolupem un nou mètode computacional per a la dependència freqüencial en forma de llei de potència de l'absorció característica dels teixits biològics. Aquest mètode en domini temporal és usat posteriorment per a revisar els processos bàsics no lineals prestant especial interés en el paper de la dispersió del teixit. Per últim, la resolució de les equacions constitutives ens permet abordar la descripció no lineal de la força de radiació acústica produïda en teixits biològics, i les implicacions existents amb la deposició d'energia i transferència de moment per a ones ultrasòniques d'alta intensitat. L'ampli ventall de processos no lineals analitzats en aquesta tesi contribueix a una millor comprensió de la dinàmica de les ones acústiques d'alta intensitat en medis complexos, on les implicacions existents quant a la millora de les seues aplicacions practiques són posades de manifest.
Jiménez González, N. (2015). Nonlinear Acoustic Waves in Complex Media [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/53237
TESIS
Premiado

Das ultraschallunterstützte Rührreibschweißen (USE-FSW) als innovatives Hybrid-Pressschweißverfahren zeichnet sich durch eine Reihe von Vorteilen aus, welche es für die Kombination artfremder metallischer Werkstoffe mit deutlich unterschiedlichem Schmelzpunkt ermöglichen, qualitativ hochwertigere Verbunde zu realisieren. Die vorliegende Arbeit thematisiert experimentelle Untersuchungen der Auswirkungen des zusätzlich eingekoppelten Leistungsultraschalls auf das Prozessverhalten und die Bindungsmechanismen sowie daraus resultierender mechanischer Verbundeigenschaften beim ultraschallunterstützten Rührreibschweißen von Aluminium/Stahl-Verbunden. Im Anschluss an die Ermittlung geeigneter Parameter für das konventionelle Rührreibschweißen erfolgen grundlegende Betrachtungen des Einflusses des Leistungsultraschalls auf das Schwingungsverhalten, das thermische Verhalten und das insitu- Prozesskraftverhalten, aus denen bestmögliche Ultraschallparameter abgeleitet werden. Nachfolgende detaillierte, vergleichende Untersuchungen des konventionellen und des ultraschallunterstützten Rührreibschweißprozesses belegen unter anderem eine Reduktion der Dicke spröder, aluminiumreicher intermetallischer Phasen am Verbund-Interface des USE-FSW-Verbundes, was in einer Erhöhung der Zugfestigkeit und der Duktilität resultiert.
The ultrasound enhanced friction stir welding (USE-FSW) as an innovative hybrid solid state joining process is characterized by a number of advantages that enable the realization of higher quality joints for the combination of dissimilar, metallic material combinations with strongly differing melting points. The present work addresses the impact of the additional power ultra- sound transmission on the process behavior and the bonding mechanisms as well as resulting mechanical joint properties for the ultrasound enhanced friction stir welding of aluminum/steel joints via experimental investigations. Subsequent to the determination of suitable parameters for the conventional friction stir welding basic considerations of the power ultrasound influence on the oscillation behavior, the thermal behavior and the in-situ process force behavior take place for deriving a best possible set of ultrasound parameters. Moreover, the conventional and the ultrasound enhanced friction stir welding process are investigated comparatively in detail, proving a reduction in thickness for brittle, aluminum-rich intermetallic phases at the USE-FSW joint interface among other things, resulting in an improved tensile strength and ductility.

Le contexte d’étude est celui du développement de la plate-forme logicielle CIVA, dédiée notamment à la simulation du Contrôle Non-Destructif (CND) par ultrasons. Le calcul de champ hérite de la méthode des rayons, et peut souffrir – dans des configurations particulières – de la présence de caustiques et d’ombrages. Les faisceaux gaussiens sont des candidats pertinents dans la régularisation de ces singularités, et l’objectif est de développer et valider une méthode efficace de calcul de champ par superposition de faisceaux gaussiens. Un travail bibliographique préliminaire a permis de mettre en évidence la problématique associée à l’initialisation de ces faisceaux gaussiens, dont les méthodes diffèrent selon les auteurs et les champs disciplinaires. Du point de vue du CND, la variété physique et la complexité géométrique des pièces à inspecter guide le modélisateur vers un traitement le plus générique possible. Une façon d’initialiser une famille de faisceaux gaussiens consiste à représenter la donnée du problème posé (conditions initiales et/ou aux bords) par un espace fonctionnel vérifiant les propriétés d’un frame. En munissant le frame d'un noyau gaussien, on génère à l’aide d’algorithmes rapides un ensemble univoque de conditions initiales pour une famille de faisceaux gaussiens. La superposition de ces derniers fournit alors une solution approchée au problème. Dans le cadre de cette thèse, cette stratégie est déclinée en régimes transitoire et harmonique. La contribution majeure de ces travaux réside dans la validation quantitative de cette initialisation par frame, par l’application à des configurations représentatives du CND par ondes de volume ultrasonores
This works is part of the CIVA software development. CIVA is dedicated to non-destructive testing (NDT) simulation, and especially to efficient ultrasonic bulk wave simulation. However, its modeling approach, based on the ray theory under high frequency assumption, may suffer – in some specific cases – from caustics and shadowing effects. Gaussian beams are known to be suitable candidates for removing those singularities, and the purpose of this research work is to develop and validate an efficient computing method using Gaussian beam superpositions. A preliminary review of literature revealed an underlying problematic related to the Gaussian beam initialization. Indeed, there is no standard method for initializing a relevant set of Gaussian beams: existing approaches differ, depending on the authors and on the examples they discuss. From the perspective of NDT modeling, it is still necessary to develop a numeric solution which is generic enough to indiscriminately handle a wide variety of materials, geometries and input data. One way of adressing Gaussian beam initialization is - for a given problem - to obtain a frame representation of the initial and/or boundary conditions. By choosing a Gaussian kernel, it is then possible to generate an unequivocal set of initial Gaussian beam parameters. Finally, the approximated solution is given by the corresponding propagated Gaussian beams. In this work, we derived this frame approach in both time and frequency domains. The main contribution of this thesis research lies in the quantitative validation of this method, through typical configurations of ultrasonic NDT

Peripheral vascular grafts are used for the treatment of peripheral arterial disease and arteriovenous grafts for vascular access in end stage renal disease. The development of neo-intimal hyperplasia and thrombosis in the distal anastomosis remains the main reason for occlusion in that region. The local haemodynamics produced by a graft in the host vessel is believed to significantly affect endothelial function. Single spiral flow is a normal feature in medium and large sized vessels and it is induced by the anatomical structure and physiological function of the cardiovascular system. Grafts designed to generate a single spiral flow in the distal anastomosis have been introduced in clinical practice and are known as spiral grafts. In this work, spiral peripheral vascular and arteriovenous grafts were compared with conventional grafts using ultrasound and computational methods to identify their haemodynamic differences. Vascular-graft flow phantoms were developed to house the grafts in different surgical configurations. Mimicking components, with appropriate acoustic properties, were chosen to minimise ultrasound beam refraction and distortion. A dual-beam two-dimensional vector Doppler technique was developed to visualise and quantify vortical structures downstream of each graft outflow in the cross-flow direction. Vorticity mapping and measurements of circulation were acquired based on the vector Doppler data. The flow within the vascular-graft models was simulated with computed tomography based image-guided modelling for further understanding of secondary flow motions and comparison with the experimental results. The computational assessments provided a three-dimensional velocity field in the lumen of the models allowing a range of fluid dynamic parameters to be predicted. Single- or double-spiral flow patterns consisting of a dominant and a smaller vortex were detected in the outflow of the spiral grafts. A double- triple- or tetra-spiral flow pattern was found in the outflow of the conventional graft, depending on model configuration and Reynolds number. These multiple-spiral patterns were associated with increased flow stagnation, separation and instability, which are known to be detrimental for endothelial behaviour. Increased in-plane mixing and wall shear stress, which are considered atheroprotective in normal vessels, were found in the outflow of the spiral devices. The results from the experimental approach were in agreement with those from the computational approach. This study applied ultrasound and computational methods to vascular-graft phantoms in order to characterise the flow field induced by spiral and conventional peripheral vascular and arteriovenous grafts. The results suggest that spiral grafts are associated with advanced local haemodynamics that may protect endothelial function and thereby may prevent their outflow anastomosis from neo-intimal hyperplasia and thrombosis. Consequently this work supports the hypothesis that spiral grafts may decrease outflow stenosis and hence improve patency rates in patients.

Le projet de normalisation européenne c. E. N. /t. C. 138 présente des méthodes et des critères en vue de vérifier et caractériser les appareils et traducteurs utilisés en contrôle non destructif par ultrasons. Le but de cette thèse est de montrer l'applicabilité des méthodes proposées, et d'en effectuer une analyse critique. Nous avons porté notre attention sur les méthodes de caractérisation des traducteurs immersions proposées par le projet de norme c. E. N. /t. C. 138 n 237 et compare les résultats à ceux obtenus par interférométrie laser. Des simulations sur un modèle simplifié nous permettent de compléter l'analyse des différents résultats expérimentaux. L'influence de la taille du réflecteur sphérique sur le champ ultrasonore a été particulièrement étudiée. L'analyse des méthodes définies par le projet de norme c. E. N. /t. C. 138 n 230 sur la vérification des appareils ultrasonores utilisés en contrôle non destructif par ultrasons, est proposée par la mise au point d'un banc de mesure informatisé conforme aux textes de norme. Pour ce faire, nous avons développé un logiciel d'assistance informatique, Verapus qui guide l'operateur dans le déroulement des protocoles de vérification.

Les structures planes supportent la propagation de modes de Lamb, dont certains présentent une vitesse de groupe nulle et une vitesse de phase finie. Ces modes ZGV, favorablement engendrés et détectés par ultrasons laser, donnent lieu à des résonances locales étroites qui sont sensibles à l'épaisseur, aux propriétés élastiques et aux conditions de surface. Dans le premier volet de cette thèse, l'optimisation spatiale de la source laser (Faisceau rectangle ou Gaussien, anneau à profil rectangle ou Gaussien obtenu à l'aide d'un axicon) est étudiée afin d'améliorer la génération d'un mode de Lamb de longueur d'onde λ. Il est démontré que le rayon optimal d'un faisceau Gaussien est égal à λ/π. Les résultats théoriques sont en bon accord avec les simulations semi-analytiques et les mesures réalisées à la fréquence du mode ZGV S1S2 dans une plaque de Duralumin. Le second volet est dédié au contrôle de plaques collées par résonance ZGV. Ces structures sont décrites par un modèle rhéologique adhésif faisant intervenir des raideurs d'interface. La sensibilité des fréquences ZGV aux paramètres de la couche d'adhésif et aux raideurs d'interface est étudiée. La mesure des résonances ZGV a conduit à l'obtention des cartes de raideurs et d'épaisseur de colle. Elle a également permis de différencier des assemblages à tenue mécanique contrôlée
For some Lamb modes propagating in plane structures, the group velocity vanishes while the phase velocity remains finite. These modes are associated with local and narrow resonances and are sensitive to thickness, elastic properties and boundary conditions. Laser ultrasound techniques are well suited to generate and detect these resonances. In the first part of this thesis, spatial optimization of laser sources (Top-Hat and Gaussian beam, rectangular and Gaussian ring produced by an axicon-lens system) are studied in order to enhance the generation of a Lamb mode at wavelength λ. Optimal radius of a Gaussian beam is demonstrated to be λ/π. Theoretical results are shown to be in a good agreement with semi-analytical simulation and experimental results performed in a Duralumin plate at the S1S2-ZGV mode frequency. The second part of this work is dedicated to the use of ZGV resonances for the inspection of bonded plates. Trilayers are described by rheological model where interfaces are modelized by stiffnesses. The sensitivity of ZGV frequencies to the interfacial stiffnesses as well as adhesive layer parameters has been studied. Stiffnesses and adhesive thickness maps have been extracted from ZGV resonance measurements. In addition, ZGV mode measurements have been shown to allow the differenciation of controled bond strengh samples

On étudie l'interaction entre un faisceau ultrasonore borné monochromatique et une structure stratifiée plane immergée dans un fluide. La structure est composée de deux couches de matériaux élastiques anisotropes. La structure réelle comporte un défaut de collage, de longueur finie, situé sur cette interface interne. L'objectif de l'étude est de proposer une simulation numérique permettant d'apprécier dans quelle mesure l'analyse du faisceau ultrasonore restitué par la structure permet de détecter la présence du défaut. La représentation du faisceau fait appel à une superposition en ondes planes et utilise les transformées de Fourier rapides. L'approximation de Kirchhoff est introduite. On traite ensuite le défaut comme un émetteur passif. Des études numériques sont proposées afin d'apprécier dans quelles situations le défaut pourra être détecté. La génération d'ondes de Lamb peut faciliter cette détection
The interaction between an acoustic ultrasonic bounded beam and a multilayered structure immersed in a fluid has been studied. The structure is composed of two anisotropic elastic layers. When the structure is sound, the real structure shows a bonded finite length crack, localised on this internal interface. The aim of this study is to propose a numerical simulation in order to estimate in what extend the analysis of the ultrasonic beam restored by the structure is able to detect the presence of the crack. The representation of the beam uses plane wave decomposition and requires fast Fourier transforms. Kirchhoff’s approximation is introduced. Then the crack is treated as a passive transducer. Numeral studies are proposed in order to estimate in what circumstances crack could be detected. Lamb wave generation could improve the detection

碩士
國立清華大學
電機工程學系所
106
Recently, ultrasound imaging with coherent plane wave compounding has played an important role in high-quality ultrafast imaging and shear wave elastography, leveraging multiple angled plane-wave emissions. In this study, we propose an angle selection strategy for ultrasound imaging with coherent plane wave compounding (CPWC), featuring lower grating-lobe and ghost artifacts while fewer angled plane-wave emissions are required compared to commonly used equal-angular-spacing decimation in the angle sequence (EAS-CPWC). In our strategy, the relation between conventional synthetic transmit aperture imaging and CPWC is discovered. Given the number of the total tilted plane-wave excitations, with our angle selection strategy, the synthesized effective aperture by the CPWC approximates to the desired two-way effective aperture with an appropriate width, element spacing, and shape; thus enabling grating-lobe and ghost artifacts suppression. Field II simulations and experiments on wire, anechoic cyst phantoms and the ex vivo porcine artery were performed to verify our angle-selection strategy. Simulation and experimental results showed that with our proposed angle sequence, the grating-lobe and ghost artifacts were suppressed by 5 dB and 15 dB respectively, and 25 ± 5 % contrast-to noise ratio (CNR) improvement was achieved. Overall, we demonstrated the efficacy of our proposed angle sequence for grating-lobe and ghost artifacts suppression.

碩士
長庚大學
電機工程學系
101
Focused ultrasound has been confirmed to be able to temporally open the blood-brain barrier and has the potential for transcranially and locally enhanced the drug delivery into the brain. To fulfill this, the ultrasound need to be designed to be operated at low frequency so that the energy can be transcranially delivered into the deep-seated brain. Moreover, in order to perform focal ultrasound energy scanning to conform the planned targeting volume, the use of focused ultrasound phased array to electrically off-center steering and scanning is necessary. The aim of this study is to perform measurement of the transcranial low-frequency ultrasound wave pressure field. In experimental setup, the first one is a single-channel ultrasound to perform transcranial pressure loss among various human skull cadavers. The second one is to perform the measurement of the 256-channel ultrasound transducer for off-center steering wave field measurement in the free-field. Experimental results demonstrated that the ultrasound transmission pressure loss depends on the operating frequency (ranging from 35.2% to 24.8% from 300 to 600kHz) and the skull thickness and porosity (34.7±8.3%, 31.5±7.9%, and 32.4±5.3% in three skull cadavers). The off-center steering capability were also confirmed by using the 256-channel ultrasound phased array measured in the free-field and provide good correlations with the simulated predicted one.

碩士
國立成功大學
醫學資訊研究所
102
Synthetic aperture focusing technique (SAFT) has been proposed to improve the lateral resolution of ultrasound image outside the focal region of the transducer. However, SAFT would result an unexpected artifact image at the region near the focal point of transducer; which is due to the use of a virtue source concept associated with limited numbers of scan lines. The artifact image could be eliminated by using an appropriate time gain compensation (TGC). However, TGC is subjective to users’ settings. To further improve this issue, the present study incorporated the transducer’s depth-dependency beam characteristics into SAFT imaging procedure. Ultrasound images were acquired using different frequency of single element transducers. Initially, the beam widths of transducer were estimated from B-mode wire images using from -3 to -20dB width. Due to the erroneous time delay in accompanying with geometric calculation, the time delay was also estimated from those B-mode wire images. The -20dB beam width of transducer as a function of axial depth were measured for better estimating the time delay of each scanning point. The modified SAFT were verified by means of self-made phantoms with wire targets and contrast targets and in-vivo images. With the experiments, the modified SAFT images with the correction of beam width of the transducer may not only retain the advantages of original SAFT but also improve the artifact image near the focal region. The beam widths of transducer estimated from B-mode wire images using from -6 to -20dB width could be incorporated into SAFT imaging procedure and the modified SAFT was adaptive to different frequency of single element transducers. These results show that current modified SAFT-based imaging may greatly enhance ultrasound image quality for further clinical applications.

Gegenstand und Ziel: Einsatz des Ultraschallkontrastmittels SonoVue® zur Ermittlung der Hepatischen Transitzeit bei lebergesunden Hunden. Material und Methoden: Untersucht wurden 45 lebergesunde Hunde aus dem Patientengut der Klinik für Kleintiere der Universität Leipzig. Ausschlusskriterien waren Leber- und Herz-Kreislauferkrankungen, sowie Tumorleiden. Die Kontrastmitteluntersuchungen erfolgten am narkotisierten Tier. Das Kontrastmittel wurde intravenös appliziert. Die Zeitdifferenz zwischen Ankunft in den Leberarterien bis zum Erreichen der Lebervenen wird als Hepatische Transitzeit definiert. Die Auswertung erfolgte von zwei unabhängigen Betracht-ern, sowie einer im Ultraschallgerät installierten Analysesoftware (TIC; Time-intensity-curve). Erfasst wurden zusätzlich von jedem Patienten die Blutflussgeschwindigkeiten in der Aorta abdominalis und den Lebervenen vor und nach der Kontrastmitteluntersuchung. Ebenfalls sind die Ankunftszeiten des Kontrastmittels in den Leberarterien und Lebervenen ermittelt worden. Diese Daten wurden mit den Angaben des Alters, dem Geschlecht und dem Gewicht verglichen. Die ermittelten Ankunftszeiten des Kontrastmittels wurden mit den Blutflussgeschwindigkeiten des jeweiligen Patienten korreliert. Ergebnisse: Die Hepatische Transitzeit des Kontrastmittels SonoVue® für lebergesunde Hunde beträgt 9,82 s. Schlussfolgerungen: Die Hepatische Transitzeit des Signalverstärkers SonoVue® beim lebergesunden Hund liegt bei 9,82 s und ist damit ca. eine Sekunde kürzer als beim Men-schen. In anschließenden Studien muss bei Hunden mit nachgewiesenen Lebermetastasen die Hepatische Transitzeit ermittelt werden. Entsprechen die Ergebnisse denen aus der Human-medizin, so ist mit einer Verkürzung der Hepatischen Transitzeit zu rechnen. Insbesondere bei bekanten Primärtumor könnte mit dieser Methode eine Metastasierung früher erkannt werden.