Journal articles: 'Ultrasonic therapeutic apparatus'

1

Sakurai, Tomoshisa. "Ultrasonic therapeutic apparatus." Journal of the Acoustical Society of America 102, no. 1 (July 1997): 26. http://dx.doi.org/10.1121/1.419741.

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Young, Michael J. R., and Brian R. D. P. Bradnock. "Apparatus for ultrasonic therapeutic treatment." Journal of the Acoustical Society of America 101, no. 5 (1997): 2430. http://dx.doi.org/10.1121/1.418478.

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Gavin, Graham P., Finbar Dolan, M. S. J. Hashmi, and Garrett B. McGuinness. "A Coupled Fluid-Structure Model of a Therapeutic Ultrasound Angioplasty Wire Waveguide." Journal of Medical Devices 1, no. 4 (August 31, 2007): 254–63. http://dx.doi.org/10.1115/1.2812424.

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Ultrasonic longitudinal displacements, delivered to the distal tips of small diameter wire waveguides, are known to be capable of disrupting complicated atherosclerotic plaques during vascular interventions. These ultrasonic displacements can disrupt plaques not only by direct contact ablation but also by pressure waves, associated cavitation, and acoustic streaming developed in the surrounding blood and tissue cavities. The pressure waves developed within the arterial lumen appear to play a major role but are complex to predict as they are determined by the distal tip output of the wire waveguide (both displacement and frequency), the geometric features of the waveguide tip, and the effects of biological fluid interactions. This work describes a numerical linear acoustic fluid-structure model of an ultrasonic wire waveguide and the blood surrounding the distal tip. The model predicts a standing wave structure in the wire waveguide, including stresses and displacements, and requires the incorporation of a damping constant. The effects on waveguide response of including an enlarged ball tip at the distal end of the waveguide, designed to enhance cavitation and surface contact area, are investigated, in addition to the effects of the surrounding blood on the resonant response of the waveguide. The model also predicts the pressures developed in the acoustic fluid field surrounding the ultrasonic vibrating waveguide tip and can predict the combinations of displacements, frequencies, and waveguide geometries associated with cavitation, an important event in the disruption of plaque. The model has been validated against experimental displacement measurements with a purpose built 23.5 kHz nickel-titanium wire waveguide apparatus and against experimental pressure measurements from the literature.

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Larson, Blake T., Arthur G. Erdman, Nikolaos V. Tsekos, Essa Yacoub, Panagiotis V. Tsekos, and Ioannis G. Koutlas. "Design of an MRI-Compatible Robotic Stereotactic Device for Minimally Invasive Interventions in the Breast†." Journal of Biomechanical Engineering 126, no. 4 (August 1, 2004): 458–65. http://dx.doi.org/10.1115/1.1785803.

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The objective of this work was to develop a robotic device to perform biopsy and therapeutic interventions in the breast with real-time magnetic resonance imaging (MRI) guidance. The device was designed to allow for (i) stabilization of the breast by compression, (ii) definition of the interventional probe trajectory by setting the height and pitch of a probe insertion apparatus, and (iii) positioning of an interventional probe by setting the depth of insertion. The apparatus is fitted with five computer-controlled degrees of freedom for delivering an interventional procedure. The entire device is constructed of MR compatible materials, i.e. nonmagnetic and non-conductive, to eliminate artifacts and distortion of the MR images. The apparatus is remotely controlled by means of ultrasonic motors and a graphical user interface, providing real-time MR-guided planning and monitoring of the operation. Joint motion measurements found probe placement in less than 50 s and sub-millimeter repeatability of the probe tip for same-direction point-to-point movements. However, backlash in the rotation joint may incur probe tip positional errors of up to 5 mm at a distance of 40 mm from the rotation axis, which may occur for women with large breasts. The imprecision caused by this backlash becomes negligible as the probe tip nears the rotation axis. Real-time MR-guidance will allow the physician to correct this error. Compatibility of the device within the MR environment was successfully tested on a 4 Tesla MR human scanner.

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Zhang, Peizhen, Pengdong Li, Shihai Liao, Xuan Li, Wufan Chen, Xiaoyun Wang, and Qing Wang. "Fracture Nonunion Treated with Low-Intensity Pulsed Ultrasound and Monitored with Ultrasonography: A Feasibility Study." BioMed Research International 2021 (January 25, 2021): 1–5. http://dx.doi.org/10.1155/2021/8834795.

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The positive effect of low-intensity pulsed ultrasound (LIPUS) on bone fracture healing has been proved. However, during the period of LIPUS therapy, it is undetermined whether LIPUS promotes the formation of heterotopic ossification (HO), which usually occurs in muscle tissues after trauma such as bone fracture and spinal cord injury. Here, we used 6-week LIPUS therapy in a 42-year-old Chinese male patient with a fracture nonunion in combination with ultrasonography for monitoring fracture healing and HO formation. After the LIPUS therapy, the mineralized bone formation in the area of defect of the distal tibia was presented in an ultrasound image, which was consistent with the outcome of plain radiography showing callus formation and the blurred fracture line in the area exposed to LIPUS. In addition, ultrasound images revealed no evidence of HO development within soft tissues during the period of LIPUS therapy. This study suggests that ultrasonography is a potential tool to guarantee the performance of LIPUS therapy with monitoring HO formation. Easy to use, the integration of the handheld ultrasound scanner and the ultrasonic therapeutic apparatus is entirely dedicated to help orthopedists make high-quality care and diagnosis.

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Orekhova, L. Yu, E. S. Loboda, E. V. Grinenko, and R. S. Musaeva. "The effectiveness of complex conservative periodontal therapy using a gentle treatment technique by ultrasonic apparatus with calcium hydroxide polishing suspension among patients with type 1 diabetes and chronic generalized periodontitis." Periodontology 24, no. 3 (September 21, 2019): 223–31. http://dx.doi.org/10.33925/1683-3759-2019-24-3-223-231.

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Relevance: the presence of somatic disease is often the main and aggravating factor in development of chronic generalized periodontitis. Treatment of inflammatory periodontal diseases begins with mechanical removal of dental calculus and biofilm on a surface of the teeth. For this purpose along with traditional manual tools are applied sonic ultrasonic, and vibrascalers. Atraumatic and high efficiency of professional oral hygiene complex are extremely important for the treatment of periodontal disease in patients with diabetes. Purpose – to study the effectiveness of professional oral hygiene with use of the Vector apparatus in patients with type 1 diabetes. Materials and methods: this article presents study results of the effectiveness of the Vector ultrasound device use as part of therapeutic and preventive measures complex among 3 patients in different ages with generalized periodontitis and type 1 diabetes mellitus. We conducted a dental and X-ray examination and microbiological analysis of periodontal space contents. All patients underwent professional oral hygiene and Vector-therapy. Results were evaluated after 1 month. Results: using the example of 3 clinical cases, the effectiveness of professional oral hygiene complex was presented. After 4 weeks there were observed the reduction of patients complaints for bleeding gums when brushing teeth, improving hygienic and periodontal indices, reducing the composition and number of periodontal pathogens. Conclusion: treatment of inflammatory periodontal diseases using the Vector system is recommended as an early prevention of the development of a more severe periodontitis, as well as the most benign and minimally invasive treatment for periodontal diseases due to its high effectiveness.

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Ishibashi, Yoshiharu. "Ultrasound therapeutic apparatus." Journal of the Acoustical Society of America 113, no. 4 (2003): 1797. http://dx.doi.org/10.1121/1.1572389.

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Forssmann, Bernd. "Apparatus and method for triggering therapeutic shock waves." Journal of the Acoustical Society of America 84, no. 6 (December 1988): 2308. http://dx.doi.org/10.1121/1.396768.

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Brisken, Axel F. "Methods and apparatus for uniform transcutaneous therapeutic ultrasound." Journal of the Acoustical Society of America 114, no. 5 (2003): 2553. http://dx.doi.org/10.1121/1.1634155.

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LAVRINENKO, YE E. "Low-Frequency Ultrasound Therapy in Combination Treatment of Patients with Type 2 Diabetes Mellitus." INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), no. 3.51 (March 10, 2013): 30–34. http://dx.doi.org/10.22141/2224-0721.3.51.2013.84315.

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Background. Hypoglycemic therapy used at present in patients with type 2 diabetes mellitus (DM) does not always lead to desired result and many patients live in a state of constant decompensation of metabolic processes, with the high levels of glycemia and glycosuria. That is why the search for the optimal treatment strategy that could increase the effectiveness of hypoglycemic therapy, and reduce the risk of complications is one of the most actual problems of modern diabetology.The purpose of this study was to determine the use of low-frequency ultrasound therapy on cutaneous projection of the liver in patients with type 2 DM.Materials and Methods. 30 patients with newly diagnosed type 2 DM and body mass index (BMI) greater than 25 kg/m2 were treated by the low-frequency ultrasound therapy. The ultrasonic effects were conducted in pulsed mode of 44 kHz and an amplitude of fluctuations — 2 microns using the apparatus MIT-11 as follows. Effects on the area of liver projection in patients was performed by the immovable technique (method), exposure to a session consisted of 8 minutes. The vaseline oil was used as a contact substance. Additionally influence on segmental area of Th7-Th12 by labile technique for 2 minutes on each plot was used to enhance the therapeutic effect. The patients were examined before and after treatment. The dynamics of clinical symptoms, glycemia and glycosuria, level of glycated hemoglobin was taken into account to assess the effectiveness of low-frequency ultrasound. To assess the degree of insulin resistance content of insulin, C-peptide and glucagon in blood plasma were determined by radioimmunoassay. Fasting insulin, C-peptide, glucagon in blood serum were tested in the morning. The statistical processing of tests’ results was performed using Student’s t test.Results. The beginning of therapeutic effect was observed after 2 procedures of the ultrasound exposure. The maximum effect is appeared after 8–10 treatment sessions. The positive dynamics of complex treatment is improving the general state of health, a disappearance of asthenization, and a decrease in the symptoms of cardiovascular disorders, achieving faster compensation of carbohydrate metabolism. The course of treatment contributed to the hyperglycemia reduction in patients with newly detected type 2 DM. After ultrasound treatment, the authors noted a positive dynamics of clinical symptoms: an improvement of the general health status, a decrease in fatigue, an improvement of psycho-emotional indices, disappearance of pain in the right upper quadrant, and a decrease in liver size in all the patients under study. Conclusions. The use of low-frequency ultrasound therapy on cutaneous projection of the liver in patients with type 2 DM promotes the normalization both fasting and postprandial glycemia. The effect of low-frequency ultrasound on cutaneous projection of the liver is significantly decreasing parameters that characterize the pancreatic insulin synthesizing function (immunoreactive insulin, C-peptide) in patients with newly diagnosed type 2 DM and a BMI > 25 kg/m2. Low-frequency ultrasound reduces the glucagon secretion and thereby positively affects the hepatic gluconeogenesis. Ultrasound therapy can be used in the complex treatment of patients with newly diagnosed type 2 DM.

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Coffey, Kenneth W., and Gregory F. Dorholt. "Apparatus and method for substantially stationary transducer therapeutic ultrasound treatment." Journal of the Acoustical Society of America 115, no. 1 (2004): 24. http://dx.doi.org/10.1121/1.1647029.

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12

Cuervo, Armando A. "Method and apparatus for therapeutic motion and sound treatment of infants." Journal of the Acoustical Society of America 83, no. 1 (January 1988): 404. http://dx.doi.org/10.1121/1.396205.

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13

Moehring, Mark A. "Method and apparatus combining diagnostic ultrasound with therapeutic ultrasound to enhance thrombolysis." Journal of the Acoustical Society of America 115, no. 3 (2004): 963. http://dx.doi.org/10.1121/1.1697800.

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14

Skille, Olav, and Svein Sorsdal. "Apparatus and method for therapeutic application of vibro‐acoustical energy to human body." Journal of the Acoustical Society of America 92, no. 6 (December 1992): 3457. http://dx.doi.org/10.1121/1.404129.

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15

Zhang, Hui, Yue Li, Fang Rao, Chun Liufu, Yi Wang, and Zhiyi Chen. "A novel UTMD system facilitating nucleic acid delivery into MDA-MB-231 cells." Bioscience Reports 40, no. 2 (February 2020). http://dx.doi.org/10.1042/bsr20192573.

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Abstract Gene therapy is emerging as a promising method for the treatment of various diseases. The safe and efficient delivery of therapeutic nucleic acids is a gene therapy prerequisite. Ultrasound, particularly in combination with microbubbles composed of biocompatible materials such as lipid, PLGA and chitosan, is a novel non-viral tool for gene transportation. Under ultrasound irradiation, microbubbles explode and generate pores in the cell membrane. Hence, genes can enter cells more easily. In order to transfect nucleic acids into MDA-MB-231 cells in a low-cost and non-viral manner for further breast cancer gene therapy studies, we explored ultrasound targeted microbubble destruction (UTMD) technology and evaluated the efficiency and safety of the delivery of plasmid encoding enhanced green fluorescent protein (pEGFP) and a microRNA-34a (miR-34a) mimic by UTMD. Sonovitro ultrasonic apparatus was employed to generate ultrasonic field, which was developed by our group. Ultrasonic parameters, including acoustic intensity (AI), exposure time (ET) and duty cycle (DC), were optimized at 0.6 W/cm2 AI, 20 s ET and 20% DC, the cell viability was not obviously impaired. Under these conditions, the UTMD-mediated transfection efficiency of pEGFP was greater than 40%. In addition to plasmid DNA, an miR-34a mimic was also successfully introduced into the cytoplasm by UTMD and found to inhibit proliferation, induce apoptosis of MDA-MB-231 cells and regulate downstream molecules. The present study indicates that further in vivo UTMD-mediated gene therapy studies are warranted.

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16

Hormozi Moghaddam, Zeinab, Manijhe Mokhtari-Dizaji, Mohammad Ali Nilforoshzadeh, Mohsen Bakhshandeh, and Sahar Ghaffari Khaligh. "Low-intensity ultrasound combined with allogenic adipose-derived mesenchymal stem cells (AdMSCs) in radiation-induced skin injury treatment." Scientific Reports 10, no. 1 (November 17, 2020). http://dx.doi.org/10.1038/s41598-020-77019-9.

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AbstractMesenchymal stem cells are mechano-sensitive cells with the potential to restore the function of damaged tissues. Low-intensity ultrasound has been increasingly considered as a bioactive therapeutic apparatus. Optimizing transplantation conditions is a critical aim for radiation-induced skin tissue injury. Therefore, the therapeutic function of adipose-derived mesenchymal stem cells to ultrasound stimulus was examined based on the mechanical index (MI). Mesenchymal stem cells were isolated from the adipose tissues of mature guinea pigs. An ultrasound system (US) was constructed with a 40 kHz frequency. The radiation-induced skin injury model was produced on the abdominal skin of guinea pigs by 60 Gy of radiation. Then, they were divided to 7 groups (n = 42): control, sham, US (MI = 0.7), AdMSCs injection, US AdMSCs (AdMSCs, under US with MI = 0.2), AdMSCs + US (AdMSCs transplantation and US with MI = 0.7) and US AdMSCs + US (combining the last two groups). The homing of stem cells was verified with fluorescence imaging. The groups were followed with serial photography, ultrasound imaging, tensiometry, and histology. The thickness of the skin was analyzed. Functional changes in skin tissue were evaluated with Young’s modulus (kPa). One-way ANOVA tests were performed to analyze differences between treatment protocols (p < 0.05). The results of Kumar’s score showed that radiation injury was significantly lower in the treatment groups of US AdMSCs and US AdMSCs + US than other groups after 14 days (p < 0.05). There was a significant difference in skin thickness between treatment groups with control, sham, and US groups after 60 Gy radiation and were closer to the thickness of healthy skin. Young’s modulus in US AdMSCs + US, US AdMSCs, and AdMSCs + US groups demonstrated a significant difference with the other groups (p < 0.05). Young’s modulus in US AdMSCs + US and US AdMSCs treatment groups were closer to Young’s modulus of the healthy skin. The histological results confirmed the improvement of acute radiation damage in the combined treatment method, especially in US AdMSCs + US and US AdMSCs groups with increasing the epithelialization and formation of collagen. An ultrasonic treatment plan based on a mechanical index of the target medium could be used to enhance stem cell therapy.

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Kratochvíl, B., and V. Mornstein. "Use of Chemical Dosimetry for Comparison of Ultrasound and Ionizing Radiation Effects on Cavitation." Physiological Research, 2007, S77—S84. http://dx.doi.org/10.33549/physiolres.931378.

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A comparison of the effects of ultrasound produced by low- and high-frequency ultrasonic apparatuses upon biological systems is one of the basic problems when studying ultrasound cavitation effects. One possibility for how to compare these effects is the indirect method which uses well-known physical quantities characterizing the interaction of ionizing radiation with matter and which also converts these quantities to one common physical quantity. The comparison was performed with two methods applied to the chemical dosimetry of ionizing radiation. The first method employed a twocomponent dosimeter which is composed of 50 % chloroform and 50 % re-distilled water (i.e. Taplin dosimeter). The other method used a modified iodide dosimeter prepared from a 0.5 M potassium iodide solution. After irradiation or ultrasound exposure, measurable chemical changes occurred in both dosimeters. The longer the exposure, the greater the chemical changes. These effects are described by the relationship of these changes versus the exposure times in both dosimeters. The UZD 21 ultrasonic disintegrator (with a frequency of 20 kHz, 50 % power output) was used as a lowfrequency ultrasound source, and the BTL-07 therapeutic instrument (with a frequency of 1 MHz and intensity of 2 W/cm2 ) was used as a high-frequency cavitation ultrasound source. For comparison, a 60Co gamma source was applied ( 60Co, gamma energies of 1.17 and 1.33 MeV, activity of 14 PBq). Results of this study have demonstrated that the sonochemical products are generated during exposure in the exposed samples of both dosimeters for all apparatuses used. The amount of these products depends linearly upon the exposure time. The resulting cavitation effects were recalculated to a gray-equivalent dose (the proposed unit is cavitation gray [cavitGy]) based on the sonochemical effects compared to the effects of ionizing radiation from the 60Co source.

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Journal articles on the topic 'Ultrasonic therapeutic apparatus'

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