Dissertations / Theses on the topic 'Ulcers'
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Obogo, E., and E. Bassey. "Perforated duodenal ulcers associated with other complications of peptic ulcer disease." Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/27515.
Full textAdriaans, Beverley. "The aetiology and pathogenesis of tropical ulcer." Master's thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/25758.
Full textLoots, Miriam Alfonsa Maria. "Wound healing in diabetic ulcers." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/66897.
Full textSahin, Birnur. "DEVA : Treating Chroinic Leg Ulcers." Thesis, Umeå universitet, Designhögskolan vid Umeå universitet, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-172613.
Full textAngelis, Célio Damacena de [UNESP]. "Avaliação da proteção gástrica e duodenal do monoterpeno nerol em roedores." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/91622.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Este projeto se propôs a avaliar a ação farmacológica do nerol na prevenção de úlcera péptica. Nerol na dose de 60 mg/Kg por via oral exerceu proteção contra lesão gástrica induzida por etanol e por droga anti-inflamatória não esteróide (DAINE) em ratos, mas não protegeu contra úlcera duodenal induzida por cisteamina. Experimentos foram realizados para a elucidação dos mecanismos ação e verificou-se que a proteção exercida pelo Nerol não é por bloqueio dos radicais livres, por redução da secreção gástrica ou por aumento de muco, sua ação também não ocorre por formação de barreira mecânica. Verificou-se, contudo, que houve redução da motilidade gastrointestinal, o que pode ser um indicativo de redução do esvaziamento gástrico, o que contribui para o efeito gastroprotetor. A redução da motilidade gastrointestinal assim como a redução do acúmulo intestinal exercido pelo nerol foi revertida pela administração de naloxona (antagonista de receptores opióides), indicando, portanto, o envolvimento destes receptores. Através do bloqueio de fatores protetores da mucosa gástrica, verificou-se que a gastroproteção exercida pelo nerol é independente da via do óxido nítrico, de prostaglandinas e dos receptores mu opióides, porém, é dependente de compostos sulfidrílicos. Mostrou-se através da quantificação dos níveis de glutationa (GSH) e da atividade da enzima mieloperoxidase (MPO) que o tratamento com nerol mantém os níveis de compostos sulfidrílicos não-protéicos e reduz a infiltração de neutrófilos na mucosa gástrica em animais com lesão gástrica induzida por etanol. A administração aguda de nerol (doses de 60, 300, 600, 1250, 2500 ou 5000 mg/Kg) não provocou mortes nem alterações significantes nos parâmetros comportamentais até a dose de 600 mg/Kg. Neste trabalho portanto, ficou...
The present project proposed to evaluate the pharmacologic action of nerol in the prevection of peptic ulcer. It was seen that 60 mg/kg (p.o.) of nerol prevented gastric lesions induced by ethanol and no steroidal anti-inflammatory drugs (NSAID) in rats, however nerol did not have protected duodenal mucosa against cysteamine. Assays were performed to elucidation of the mechanisms of action and it was found that protection exerted by Nerol does not by block of free radicals, nor decrease gastric acid secretion nor increase mucus, its action is not by create a mechanical barrier. However It was found that nerol reduced gastrointestinal motility, this might be an indicative of slower gastric emptying that contribute to the gastric protective effect. Reduction of gastrointestinal motility, as well as the reduction of intestinal accumulation exerted by nerol was reverted by naloxone administration (antagonist of opioid receptors), therefore indicating involvement of the cited receptors. By blocking protective factors of gastric mucosa, it was verified that nerol’s gastroprotective effect does not involve nitric oxide, prostaglandin nor mu opioid receptors, but is dependent of sulfhydryl compounds. It was shown by quantifying glutathione levels (GSH) and myeloperoxidase (MPO) action that treatment with nerol keeps the levels of non proteic sulfhydryl compounds and decreases the neutrophil infiltration into the gastric mucosa in animals with ethanol-induced gastric damage. Acute administration of nerol (60, 300, 600, 1250, 2500 and 5000 mg/Kg) presented no deaths, neither significant behavior changes to doses of 60, 300 and 600 mg/kg. In this work, nerol showed a gastroprotective effect against ethanol- and indomethacin-induced lesions, and the depence of sulfhydryl compounds. The involvement of opioid receptors and the gastrointestinal... (Complete abstract click electronic access below)
Silva, Laísa Pinheiro da [UNESP]. "Avaliação dos mecanismos de ação envolvidos nas atividades antiulcerogênica e cicatrizante do extrato etanólico obtido a partir das folhas de Terminalia catappa L. (COMBRETACEAE)." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/91639.
Full textCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Terminalia catappa Linn é uma espécie comumente utilizada para arborização nas regiões tropical e subtropical. Essa espécie é também utilizada, em países da Ásia, como Taiwan, Índia, Flipinas e Indonésia, para tratamento de distúrbios hepáticos e do trato gastrointestinal. A literatura aponta que seus constituintes encontrados nos extratos polares das folhas são principalmente compostos polifenólicos, em especial os taninos. A partir desses dados e da ausência de registros na literatura sobre a ação antiulcerogênica desta espécie foram realizados estudos para avaliação dessa atividade das frações e caracterização da fração mais ativa, assim como a determinação do mecanismo de ação gastroprotetor e cicatrizante da fração ativa. A partir do extrato etanólico bruto das folhas, que em estudo anterior realizado pelo grupo demonstrou atividade gastroprotetora, antisecretória e cicatrizante, foi feita a partição com três solventes de diferentes polaridades (hexano, acetato de etila e metanol/água). As três frações oriundas destas extrações apresentaram ação gastroprotetora em úlcera induzida por etanol absoluto, porém a fração mais efetiva foi a aquosa na dose de 25 mg/Kg, selecionada para caracterizar os mecanismos de ação envolvidos na ação antiulcerogênica como: óxido nítrico (NO), prostaglandinas (PG), aumento de muco e atividade antioxidante por meio da manutenção dos níveis de glutationa e redução da atividade da enzima mieloperoxidase (MPO). Não foram observadas a participação dos grupamentos sulfidrila e ação antisecretória. Foi constatada atividade cicatrizante tanto com 7 como com 14 dias de tratamento, consecutivos, da fração aquosa. Durante o tratamento com a partição aquosa ocorreu uma...
Terminalia catappa Linn is a specie commonly used for afforestation in tropical and subtropical regions. It is used, in Asian countries, as Taiwan, India, Filipines and Indonesia, for treatment of hepatic and gastrointestinal disorders. Studies point to poliphenols as main components of polar leaves extract, specially the tannins. Based on this and in the lack of information about a possible gastroprotective action of this specie, studies for avaliation of this activity were done with fractions of the ethanolic extract, and gastroprotective action mechanisms were characterized in the most active fraction. A previous study done by our group showed the ethanolic extract as gastroprotective, antisecretory and healing. The ethanol extract were partitioned with three different solvents, hexane, etil acetate and methanol/water. The three fractions showed gastroprotective action in the model of ulcer induced by ethanol, but the most effective was aquous fraction in a dose of 25 mg/Kg, which was the one selected to the characterization of the mechanisms involved in the antiulcerogenic activity as: nitric oxide (NO), prostaglandins (PG), mucus and antioxidant activity by maintenance of glutathione levels and reduction in mieloperoxidase (MPO) enzyme activity. No participation of sulphidryls compounds and antisecretory activity were detected. The aquous fraction also showed healing action in the treatment for 7 and 14 days, in both of them was detected a down-regulation in metalloproteinase-2 (MPP-2). In a subchronic toxicity avaliation, the aquous fraction in 25 mg/Kg doesn´t presented a toxic potential. In the model of gastric ulcer induced by indomethacin, the aquous fraction in a dose of 50 mg/Kg, aggravated the lesions, which showed an evidence for antiinflamatory activity, it was confirmed in Formalin test and ear edema induced by... (Complete abstract click electronic access below)
Silva, Laísa Pinheiro da. "Avaliação dos mecanismos de ação envolvidos nas atividades antiulcerogênica e cicatrizante do extrato etanólico obtido a partir das folhas de Terminalia catappa L. (COMBRETACEAE) /." Botucatu : [s.n.], 2012. http://hdl.handle.net/11449/91639.
Full textBanca: Wagner Villegas
Banca: Walter Toma
Resumo: Terminalia catappa Linn é uma espécie comumente utilizada para arborização nas regiões tropical e subtropical. Essa espécie é também utilizada, em países da Ásia, como Taiwan, Índia, Flipinas e Indonésia, para tratamento de distúrbios hepáticos e do trato gastrointestinal. A literatura aponta que seus constituintes encontrados nos extratos polares das folhas são principalmente compostos polifenólicos, em especial os taninos. A partir desses dados e da ausência de registros na literatura sobre a ação antiulcerogênica desta espécie foram realizados estudos para avaliação dessa atividade das frações e caracterização da fração mais ativa, assim como a determinação do mecanismo de ação gastroprotetor e cicatrizante da fração ativa. A partir do extrato etanólico bruto das folhas, que em estudo anterior realizado pelo grupo demonstrou atividade gastroprotetora, antisecretória e cicatrizante, foi feita a partição com três solventes de diferentes polaridades (hexano, acetato de etila e metanol/água). As três frações oriundas destas extrações apresentaram ação gastroprotetora em úlcera induzida por etanol absoluto, porém a fração mais efetiva foi a aquosa na dose de 25 mg/Kg, selecionada para caracterizar os mecanismos de ação envolvidos na ação antiulcerogênica como: óxido nítrico (NO), prostaglandinas (PG), aumento de muco e atividade antioxidante por meio da manutenção dos níveis de glutationa e redução da atividade da enzima mieloperoxidase (MPO). Não foram observadas a participação dos grupamentos sulfidrila e ação antisecretória. Foi constatada atividade cicatrizante tanto com 7 como com 14 dias de tratamento, consecutivos, da fração aquosa. Durante o tratamento com a partição aquosa ocorreu uma... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Terminalia catappa Linn is a specie commonly used for afforestation in tropical and subtropical regions. It is used, in Asian countries, as Taiwan, India, Filipines and Indonesia, for treatment of hepatic and gastrointestinal disorders. Studies point to poliphenols as main components of polar leaves extract, specially the tannins. Based on this and in the lack of information about a possible gastroprotective action of this specie, studies for avaliation of this activity were done with fractions of the ethanolic extract, and gastroprotective action mechanisms were characterized in the most active fraction. A previous study done by our group showed the ethanolic extract as gastroprotective, antisecretory and healing. The ethanol extract were partitioned with three different solvents, hexane, etil acetate and methanol/water. The three fractions showed gastroprotective action in the model of ulcer induced by ethanol, but the most effective was aquous fraction in a dose of 25 mg/Kg, which was the one selected to the characterization of the mechanisms involved in the antiulcerogenic activity as: nitric oxide (NO), prostaglandins (PG), mucus and antioxidant activity by maintenance of glutathione levels and reduction in mieloperoxidase (MPO) enzyme activity. No participation of sulphidryls compounds and antisecretory activity were detected. The aquous fraction also showed healing action in the treatment for 7 and 14 days, in both of them was detected a down-regulation in metalloproteinase-2 (MPP-2). In a subchronic toxicity avaliation, the aquous fraction in 25 mg/Kg doesn't presented a toxic potential. In the model of gastric ulcer induced by indomethacin, the aquous fraction in a dose of 50 mg/Kg, aggravated the lesions, which showed an evidence for antiinflamatory activity, it was confirmed in Formalin test and ear edema induced by... (Complete abstract click electronic access below)
Mestre
Angelis, Célio Damacena de. "Avaliação da proteção gástrica e duodenal do monoterpeno nerol em roedores /." Botucatu, 2012. http://hdl.handle.net/11449/91622.
Full textBanca: Elfriede Marianne Bacchi
Banca: Luiz Claudio Di Stasi
Resumo: Este projeto se propôs a avaliar a ação farmacológica do nerol na prevenção de úlcera péptica. Nerol na dose de 60 mg/Kg por via oral exerceu proteção contra lesão gástrica induzida por etanol e por droga anti-inflamatória não esteróide (DAINE) em ratos, mas não protegeu contra úlcera duodenal induzida por cisteamina. Experimentos foram realizados para a elucidação dos mecanismos ação e verificou-se que a proteção exercida pelo Nerol não é por bloqueio dos radicais livres, por redução da secreção gástrica ou por aumento de muco, sua ação também não ocorre por formação de barreira mecânica. Verificou-se, contudo, que houve redução da motilidade gastrointestinal, o que pode ser um indicativo de redução do esvaziamento gástrico, o que contribui para o efeito gastroprotetor. A redução da motilidade gastrointestinal assim como a redução do acúmulo intestinal exercido pelo nerol foi revertida pela administração de naloxona (antagonista de receptores opióides), indicando, portanto, o envolvimento destes receptores. Através do bloqueio de fatores protetores da mucosa gástrica, verificou-se que a gastroproteção exercida pelo nerol é independente da via do óxido nítrico, de prostaglandinas e dos receptores mu opióides, porém, é dependente de compostos sulfidrílicos. Mostrou-se através da quantificação dos níveis de glutationa (GSH) e da atividade da enzima mieloperoxidase (MPO) que o tratamento com nerol mantém os níveis de compostos sulfidrílicos não-protéicos e reduz a infiltração de neutrófilos na mucosa gástrica em animais com lesão gástrica induzida por etanol. A administração aguda de nerol (doses de 60, 300, 600, 1250, 2500 ou 5000 mg/Kg) não provocou mortes nem alterações significantes nos parâmetros comportamentais até a dose de 600 mg/Kg. Neste trabalho portanto, ficou... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The present project proposed to evaluate the pharmacologic action of nerol in the prevection of peptic ulcer. It was seen that 60 mg/kg (p.o.) of nerol prevented gastric lesions induced by ethanol and no steroidal anti-inflammatory drugs (NSAID) in rats, however nerol did not have protected duodenal mucosa against cysteamine. Assays were performed to elucidation of the mechanisms of action and it was found that protection exerted by Nerol does not by block of free radicals, nor decrease gastric acid secretion nor increase mucus, its action is not by create a mechanical barrier. However It was found that nerol reduced gastrointestinal motility, this might be an indicative of slower gastric emptying that contribute to the gastric protective effect. Reduction of gastrointestinal motility, as well as the reduction of intestinal accumulation exerted by nerol was reverted by naloxone administration (antagonist of opioid receptors), therefore indicating involvement of the cited receptors. By blocking protective factors of gastric mucosa, it was verified that nerol's gastroprotective effect does not involve nitric oxide, prostaglandin nor mu opioid receptors, but is dependent of sulfhydryl compounds. It was shown by quantifying glutathione levels (GSH) and myeloperoxidase (MPO) action that treatment with nerol keeps the levels of non proteic sulfhydryl compounds and decreases the neutrophil infiltration into the gastric mucosa in animals with ethanol-induced gastric damage. Acute administration of nerol (60, 300, 600, 1250, 2500 and 5000 mg/Kg) presented no deaths, neither significant behavior changes to doses of 60, 300 and 600 mg/kg. In this work, nerol showed a gastroprotective effect against ethanol- and indomethacin-induced lesions, and the depence of sulfhydryl compounds. The involvement of opioid receptors and the gastrointestinal... (Complete abstract click electronic access below)
Mestre
Debacker, Martine M. J. "L'ulcère de Buruli dans un centre de santé rural au Bénin." Doctoral thesis, Universite Libre de Bruxelles, 2005. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211042.
Full textUne première publication porte sur 1700 cas consécutifs admis au CSNG entre 1997 et 2001. Ces données nous ont permis d’illustrer l’évolution du nombre des cas d’UB au cours des années, par département et par sous-préfecture. Le nombre de patients UB qui se présentent au centre est fonction de différents facteurs comme par exemple l’ouverture d’autres centres de traitement, l’organisation de campagnes d’information sur l’UB mais aussi de changements dans l’environnement. Au niveau des formes de la maladie, nous avons montré que les formes non ulcérées sont aussi fréquentes que les formes ulcérées. La forme de la maladie est liée au délai à consulter le CSNG. Les atteintes osseuses sont fréquentes et sont présentes chez plus de 13% des cas. Au fil des années, le délai à consulter le CSNG ainsi que la durée de l’hospitalisation ont été fortement réduits, passant de 4 mois à 1 mois dans le premier cas et de 9 mois à 1 mois en ce qui concerne l’hospitalisation. Les personnes ressources à cibler lors des campagnes de sensibilisation sur la maladie ont été identifiées. Il s’agit des anciens malades, qui dans 68% des cas, réfèrent les nouveaux malades au CSNG.
Une deuxième publication, portant sur la même période, nous a permis de mettre en évidence pour la première fois des taux d’UB élevés chez les sujets de 60 ans et plus, probablement du fait d’une diminution de leur immunité. Chez les 60 ans et plus, les hommes sont plus à risque de développer un UB que les femmes. Par contre aucune différence dans le risque d’UB en fonction du sexe n’est trouvée chez les moins de 60 ans. Les lésions d’UB prédominent au niveau des membres inférieurs pour tous les groupes d’âge. Du fait de leur petite stature, les enfants ont une répartition des lésions qui touchent tout le corps. Chez les adultes, les femmes présentent plus de lésions que les hommes au niveau de la tête, du cou et du tronc. Les sujets de moins de 15 ans développent souvent des lésions multifocales, associées à des atteintes osseuses. Ces atteintes osseuses constituent les formes graves de la maladie.
Notre troisième publication porte sur le suivi des malades au niveau des villages, entre mars 2000 et février 2001, afin de déterminer les taux de récurrences de l’UB. Le taux de récurrence de la maladie est faible (6.1%) pour un temps de suivi des malades allant jusqu’à 7 ans. La majorité des malades soignés au CSNG étaient en bonne santé. Nous n’avons néanmoins pu retrouver qu’un nombre limité de malades.
Dans notre quatrième publication, nous avons pu mettre en évidence le développement d’un UB sur le site d’une morsure humaine. La surface de la peau du malade a pu être contaminée par M. ulcerans et la morsure (= traumatisme) a occasionné l’entrée de M. ulcerans dans le derme. Une autre explication plausible est que la morsure ait réactivé un foyer latent de M. ulcerans au niveau du site de la morsure.
Notre base de données nous a également permis de contribuer à d’autres études, notamment celles sur l’influence du BCG et de la schistosomiase sur l’UB. Dans les deux cas, nous trouvons une association significative avec les formes graves de l’UB, l’absence de vaccination BCG et la schistosomiase favorisant le développement de formes osseuses. Aucun lien n’a pu être établi entre la présence ou l’absence de l’infection à Schistosoma haematobium et l’UB.
Dans la dernière partie de notre travail, nous nous sommes attachés à l’étude de quelques facteurs de risque de l’UB. Nous avons montré que l’UB est essentiellement associé à l’âge, le lieu de résidence et le type d’eau utilisé. Pour les sujets de 5 ans et plus, le risque d’UB est plus élevé chez les sujets vaccinés à la naissance avec le BCG. L’analyse par strate d’âge des sujets âgés de 5 ans et plus, nous a permis de voir que dans le groupe des 50 ans et plus l’influence du type d’eau utilisé est moindre que dans les autres groupes d’âge, laissant envisager qu’un autre facteur entre en jeu :une réactivation de la maladie à la faveur d’une baisse d’immunité.
Notre étude démontre que la prise en charge de l’UB doit être pluridisciplinaire et doit pouvoir englober diverses interventions telles que :
- les campagnes d’information à la population,
- la formation du personnel sanitaire ainsi qu’une implication de l’état,
- une bonne prise en charge des malades au niveau des centres de traitement de l’UB en collaboration avec les laboratoires régionaux et internationaux,
- la confirmation microbiologique des cas,
- la mise en place d’un suivi des malades en s’appuyant sur les structures déjà mises en place pour d’autres maladies,
- la mise à disposition des populations de sources d’eau potable (puits, pompes) qui par la même occasion permettront de limiter/diminuer d’autres affections liées à la consommation d’eau non potable,
- la poursuite des activités de recherche sur un éventuel vaccin ou une médication appropriée, ainsi que sur le réservoir de M. ulcerans afin de pouvoir mettre en place des stratégies de prévention de la maladie.
Doctorat en Sciences de la santé publique
info:eu-repo/semantics/nonPublished
Tuttle, Marie S. "Microbial Bioburden in Venous Leg Ulcers." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1409912389.
Full textOliveira, Mariele Gobo de [UNESP]. "Estudo comparativo de gel de palquetas home made versus hidrocolóide no processo de cicatrização de úlcera crônicas de etiologia venosa." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/93594.
Full textFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
As úlceras venosas são impactantes e representam um grande desafio médico devido ao entrelaçamento de comorbidades e causas multifatoriais, sendo de suma importância o surgimento de inovações tecnológicas na abordagem terapêutica que sejam acessíveis aos seus portadores. Diante dessa realidade, este trabalho se propôs a abordar as úlceras venosas comparando um produto existente no mercado, Hidrocolóide (HC), com uma proposta in house, o Gel de Plaquetas (GP), através da diminuição da área, avaliação descritiva da vascularização e queixas referidas. Participaram do estudo 17 pacientes, perfazendo um total de 22 úlceras venosas que foram acompanhados durante 90 dias, utilizando um dos produtos citados, de acordo com o randomização, em associação com o uso de faixas elásticas. A distribuição do grupo, segundo a randomização foi de 13 lesões no grupo de hidrocolóide e 9 no grupo de gel de plaquetas. A média percentual de redução das áreas das feridas foi de 57,78% para hidrocolóide e de 53,45% para gel de plaquetas, não apresentando diferenças estatisticamente significativas. O desempenho dos produtos estudados apresentaram grande similaridade no percentual de redução de área, o que indica que é preciso um estudo amostral maior para evidenciar superioridade de um produto sobre o outro. Porém quando comparados, quanto ao menor tempo de acompanhamento (D15), o gel de plaquetas apresentou melhor desempenho, com redução maior do que o hidrocolóide em tempo reduzido semelhante. A análise histológica no momento pré e pós tratamento sugere que o GP atua de forma a estimular a regeneração dos tecidos (estroma coeso) e de forma mais definitiva (distribuição dos vasos difusa na derme reticular). O aspecto do fechamento da lesão é mais consistente quando comparado com os pacientes que usaram HC onde se observou a formação de uma fina epiderme frágil...
Venous ulcers are striking and represent a major challenge due to the commingling of medical comorbidities and multifactorial causes, with the emergence of great importance to technological innovations in therapeutic approaches that are accessible to their patients. Given this reality, this study proposes to address venous ulcers comparing a product on the market, hydrocolloid (HC) with a proposed in-house, the Platelet Gel (GP), by decreasing the area and descriptive evaluation of vascularization complaints referred. The study included 17 patients, a total of 22 venous ulcers who were followed for 90 days, using one of the products listed, according to the randomization, in association with the use of compression elastic. The distribution of the group, according to randomization was 13 injuries in the hydrocolloid group and 9 in the group of platelet gel. The average percentage reduction of wound areas was 57.78% for hydrocolloid and 53.45% for platelet gel, showing no statistically significant differences. The performance of the products studied showed great similarity in the percentage of area reduction, which indicates that it is necessary to study a larger sample to demonstrate the superiority of one product over another. But when compared, for the shortest time of follow-up (D15), the platelet gel performed better, with greater reductions than the hydrocolloid in a short time like that. Histological analysis in the D0 and D90 of the treatment suggests that the GP acts to stimulate the regeneration of tissues (stroma together) and more definite form (diffuse distribution of vessels in the reticular dermis). The appearance of the closure of the injury is more consistent when compared with patients who used HC we observed the formation of a thin skin, fragile, observed in histological sections showed that a distribution of vessels in the papillary dermis. Histological sections confirmed... (Complete abstract click electronic access below)
Saha, Dipanwita. "Studies on the role of bacteria isolated from ulcers of fishes in causing ulcer in Experimental Fish." Thesis, University of North Bengal, 1998. http://hdl.handle.net/123456789/1093.
Full textEmbaye, H. "Microbiological aspects of oesophagogastric ulcers in pigs." Thesis, University of Liverpool, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.384377.
Full textParisi, Maria Candida Ribeiro. "Estudo comparativo de tres metodos de classificação de ulcera em pe diabetico em população brasileira." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/308784.
Full textTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: O objetivo deste estudo foi comparar três sistemas de classificação de úlceras em pé diabético avaliando a capacidade de predição de cicatrização em 6 meses de tratamento e seguimento: o sistema de Wagner, o da Universidade do Texas (UT) e o sistema S(AD)SAD (área-profundidade, sepsis, arteriopatia e denervação). Estudamos e classificamos de acordo com cada sistema 94 portadores de Diabetes Mellitus tipo 2 e úlcera em pés. Analisamos a área da úlcera, profundidade, aspecto, presença de infecção, associação com neuropatia e isquemia nos membros inferiores. Desenvolvemos e avaliamos um novo escore obtido através da soma dos itens do sistema S(AD)SAD. O desfecho primário foi a ocorrência de cicatrização. A média de idade dos pacientes foi 57,6 anos, 48 úlceras (51,1%) cicatrizaram; 11 (12,2%) pacientes evoluíram com amputação menor. Diferenças significativas entre as úlceras que cicatrizaram e que não cicatrizaram foram encontradas em relação à profundidade (p=0,002), presença de infecção (p=0,006) e denervação (p=0,002) quando classificadas através do sistema S(AD)SAD, assim como com o sistema da UT, grau (p=0,002) e estágio (p=0,032), e com os graus do sistema de Wagner (p=0,002). Concluímos que os três sistemas foram bons preditores de cicatrização. Úlceras com S(AD)SAD escore =9 (total possível de 15) apresentaram 7,6 vezes mais chances de cicatrização que escores =10 (65,6% versus 20,0%, p<0,001). O S(AD)SAD escore pode representar uma boa ferramenta na rotina prática. Ao contrário de dados publicados em centros da Europa e Estados Unidos, demonstramos forte associação de ausência de infecção com maiores chances de cicatrização em pé diabético.
Abstract: Objective: The aim was to compare three ulcer classification systems as predictors of the outcome of diabetic foot ulcers: the Wagner, the University of Texas (UT) and the S(AD)SAD system in a specialist clinic in Brazil. Methods: Ulcer area, depth, appearance, infection, and associated ischaemia and neuropathy were recorded in a consecutive series of 94 subjects. A novel score, the S(AD)SAD score, was derived from the sum of individual items of the S(AD)SAD system, and was evaluated. Follow-up was for at least 6 months. The primary outcome measure was the incidence of healing. Results: Mean age was 57.6 years; 57 (60.6%) were male. 48 ulcers (51.1%) healed without surgery; 11 (12.2%) subjects underwent minor amputation. Significant differences in terms of healing were observed for depth (p=0.002), infection (p=0.006) and denervation (p=0.002) using the S(AD)SAD system, for UT Grade (p=0.002) and Stage (p=0.032), and for Wagner grades (p=0.002). Ulcers with a S(AD)SAD score of =9 (total possible 15) were 7.6 times more likely to heal than scores =10 (p<0.001). Conclusions: All three systems predicted ulcer outcome. The S(AD)SAD score of ulcer severity could represent a useful addition to routine clinical practice routine. The association between outcome and ulcer depth confirms earlier reports. The association with infection was stronger than reported from centres in Europe or N America.
Doutorado
Clinica Medica
Doutor em Ciências Médicas
Bosnardo, Carla Aparecida Faccio. "Análise clinica prospectiva randomizada aberta, para o tratamento das úlceras de venosas, através da terapia celular com o enxerto de queratinócitos autólogos; comparada em dois grupos, associado ou não, a Diosmina Hesperidina micronizada." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313852.
Full textTese (doutorado) - Universidade Estadual de Campinas. Faculdade de Ciências Médicas
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Resumo: Introdução: A úlcera venosa é uma complicação da insuficiência venosa crônica, atinge indivíduos adultos, afastando-os do trabalho e do convívio social normal. Objetivo: Demonstrar uma nova terapêutica para o tratamento das úlceras venosas através do enxerto de queratinócitos autólogos. Casuística e Método: Foram selecionados, de forma aleatória no ambulatório de Moléstias Vasculares Periféricas da Faculdade de Ciências Médicas da UNICAMP - Vinte e Cinco ( 25) doentes com úlcera de venosa, CEAP 6 , que não obtiveram cicatrização, das mesmas, com tratamentos convencionais; divididos em dois grupos, Grupo I- 11 doentes, 10 mulheres e 1 homem; Grupo II- 14 doentes, 11 mulheres e 3 homens. Ambos os grupos foram submetidos à aplicação do autoenxerto de queratinócitos sobre o leito limpo da úlcera; e ao grupo II, foi também ministrada dose de diosmina hesperidina micronizada a cada 12 horas. A todos os doentes, foi solicitado um repouso de 30 minutos em Trendelemburg para duas horas de atividade habitual. Os queratinócitos foram cultivados no Laboratório de Cultura de Células da Pele, CIPED- FCM - UNICAMP. Resultados: Após a aplicação de testes estatísticos não paramétricos, devido ao tipo da amostra, foi observada cicatrização e/ou melhora das úlceras com redução do leito nos dois grupos, sendo que o Grupo II obteve resultados mais precoces. Conclusão . Esse método mostra ser uma boa opção terapêutica no auxílio à cicatrização das úlceras venosas
Abstract: The venous stasis ulcer is the most severe complication of venous insufficiency, affecting adults and keeping them away from work and from normal social life. Objective: To demonstrate a new therapeutic method for accelerating healing. Methods: Twenty-five (25) patients with venous stasis ulcers, CEAP VI, who have not healed with conventional treatments were selected from the Clinic of Peripheral Vascular Diseases, Faculty of Medical Sciences, UNICAMP - were treated with autograft keratinocytes, grown in the skub cell culture laboratory, CIPED-FCM - UNICAMP. They were divided into two groups, Group I-11 patients, 10 female and male, Group II-14 patients, 11 female and 3 male. Both groups were treated with autograft keratinocytes on the clean ulcer bed, and group II, was also given a dose of micronized diosmin hesperidin every 12 hours. All the patients were asked to take a 30-minute rest in the Trendelenburg position for two hours of usual activity. Results: After the evaluation of data with statistics methods no parametric Healing and/or improvement of the ulcers with significant reduction of the bed in both groups were observed, with Group II obtaining precocious results. Conclusion? This method proves to be a good therapeutic option to help in the healing of stasis ulcers
Doutorado
Cirurgia
Doutor em Cirurgia
Paz, Bailey Gabriela. "Impact of episodic acyclovir therapy on ulcer duration and HIV shedding from ulcers among men in South Africa." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479367.
Full textBérard, Anick. "Epidemiology of venous ulcers of the lower limbs." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp03/NQ64513.pdf.
Full textBaldursson, Baldur. "Development of squamous cell carcinoma in venous ulcers /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4079-7/.
Full textRuborg, Rebecca. "The significance of tranexamic acid in bleeding ulcers." Thesis, Örebro universitet, Institutionen för läkarutbildning, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-37003.
Full textAhmad, Anwar. "Soluble urokinase plasminogen activator receptor in venous ulcers." Thesis, King's College London (University of London), 2014. https://kclpure.kcl.ac.uk/portal/en/theses/soluble-urokinase-plasminogen-activator-receptor-in-venous-ulcers(74f5dffc-db59-478e-bf87-46b476092e31).html.
Full textHolt, Jim. "Critical Commentary: Test Ulcers with Culture or PCR." Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/6488.
Full textMcGinnis, Elizabeth. "Heel pressure ulcers : a study of wound healing." Thesis, University of Leeds, 2011. http://etheses.whiterose.ac.uk/2802/.
Full textUpright, Cheryl Ann. "Evaluating patient satisfaction in the care of ulcerating metastatic skin lesions." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28800.
Full textApplied Science, Faculty of
Nursing, School of
Graduate
Shin, Vivian Yvonne, and 冼念慈. "A mechanistic study on the adverse effects of cigarette smoke extractson the delay of gastric ulcer healing." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B3122510X.
Full textWalker, Natalie K. "Epidemiological studies of leg ulcers in Auckland, New Zealand." Thesis, University of Auckland, 2000. http://hdl.handle.net/2292/3351.
Full textMakic, Mary Beth Flynn. "Evidence-based practice for the prevention of pressure ulcers /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.
Find full textTypescript. Includes bibliographical references (leaves 195-207). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
Monteiro, Silvana de Abreu Pinto Soares. "Prevalence and risk factors for gastrics ulcers in swine." Master's thesis, Faculdade de Medicina da Universidade do Porto, 2008. http://hdl.handle.net/10216/22219.
Full textWoodward, Nakia J. "What is the Best Treatment for Venous Stasis Ulcers." Digital Commons @ East Tennessee State University, 2009. https://dc.etsu.edu/etsu-works/8819.
Full textMirchandani, Smruti S. "INVESTIGATING LOW-COST OPTICAL SPECTROSCOPY FOR SENSING PRESSURE ULCERS." Miami University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=miami1501240867911294.
Full textMonteiro, Silvana de Abreu Pinto Soares. "Prevalence and risk factors for gastrics ulcers in swine." Dissertação, Faculdade de Medicina da Universidade do Porto, 2008. http://hdl.handle.net/10216/22219.
Full textAmoussouhoui, Arnaud Setondji, Roch Christian Johnson, Ghislain Emmanuel Sopoh, Ines Elvire Agbo, Paulin Aoulou, Jean-Gabin Houezo, Albert Tingbe-Azalou, Micah Boyer, and Mark Nichter. "Steps Toward Creating A Therapeutic Community for Inpatients Suffering from Chronic Ulcers: Lessons from Allada Buruli Ulcer Treatment Hospital in Benin." PUBLIC LIBRARY SCIENCE, 2016. http://hdl.handle.net/10150/621490.
Full textSuarez-Irizarry, Vivian. "Clinical Practice Guideline for Differentiating Risk Factors for Avoidable and Unavoidable Pressure Ulcers." ScholarWorks, 2018. https://scholarworks.waldenu.edu/dissertations/5661.
Full textRocasalbas, Lozano Guillermo. "Development of multifunctional biopolymeric materials for teatment of decubitus ulcers." Doctoral thesis, Universitat Politècnica de Catalunya, 2012. http://hdl.handle.net/10803/113599.
Full textFriberg, Elin, and Ulrika Sjöholm. "Trycksårsprevention - en litteraturstudie/Prevention of pressure ulcers - a literature review." Thesis, Kristianstad University College, Department of Health Sciences, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-4220.
Full textBackground: Pressure ulcers are a common problem and cause great suffering for those who develop it, and are also an expensive cost to the society. Aim: To describe nursing measures for prevention of pressure ulcers among elderly people in ordinary and nursing homes. Method: A literature review by structured analyze of scientific articles. Result: The analyze resulted in six subjects for prevention of pressure ulcers. These subjects were; risk assesment, nutrition, repositioning, skin/hygiene, nurse knowledge and documentation. Conclusion: Repositioning more often did not prevent pressure ulcers better than repositioning less frequent, nursing staff should offer patient´s pads with high absorption for peaceful rest and documentation should be improved.
Riet, Gerben ter. "Vitamin C and ultrasound in the treatment of pressure ulcers." [Maastricht : Maastricht : Rijksuniversiteit Limburg] ; University Library, Maastricht University [Host], 1994. http://arno.unimaas.nl/show.cgi?fid=6240.
Full textEbbeskog, Britt. "Elderly patients with slow-healing leg ulcers : an embodied suffering /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-492-5/.
Full textTuinea-Bobe, Cristina L. "A stretchable pressure sensor for early detection of pressure ulcers." Thesis, University of Ulster, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.528378.
Full textMani, R. "A non-invasive study of cutaneous perfusion around leg ulcers." Thesis, University of Southampton, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381262.
Full textUrrutia, Cynthia Paola Iglesias. "Issues in the evaluation of treatments for venous leg ulcers." Thesis, University of York, 2006. http://etheses.whiterose.ac.uk/9889/.
Full textBriggs, Michelle. "Painful leg ulcers : the prevalence, characteristics and effective topical treatments." Thesis, University of Leeds, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396588.
Full textAmien, Feroza. "Management of oral ulcers and oral thrush by Community Pharmacists." Thesis, University of the Western Cape, 2009. http://hdl.handle.net/11394/2834.
Full textOral ulcers and oral thrush could be indicative of serious illnesses such as oral cancer, HIV and other sexually transmitted infections (STIs), among others. There are many different health care workers that can be approached for advice and/or treatment for oral ulcers and oral thrush (sometimes referred to as mouth sores by patients), including pharmacists. In fact, the mild and intermittent nature of oral ulcers and oral thrush may most likely lead the patient to present to a pharmacist for immediate treatment. In addition, certain aspects of access are exempt at a pharmacy such as long queues and waiting times, the need to make an appointment and the cost for consultation. Thus pharmacies may serve as a reservoir of undetected cases of oral cancer, HIV and other STIs. Aim: To determine how community pharmacists in the Western Cape manage oral ulcers and oral thrush. Objectives: The data set included the prevalence of oral complaints confronted by pharmacists, how they manage oral ulcers, oral thrush and mouth sores, their knowledge about these conditions, and the influence of socio-economic status (SES) and metropolitan location (metro or non-metro) on recognition and management of the lesions. Method: A cross-sectional survey of community pharmacists in the Western Cape was conducted. A random sample of pharmacies was stratified by SES (high and low), and metropolitan location. A structured questionnaire was used to conduct a telephonic interview. The questionnaire was faxed to pharmacists 24 hours prior to the interview. Pharmacists were also telephoned 24 hours prior to the interview, but after the questionnaire was faxed, in order to gain informed consent for participation in the study, and to confirm a convenient time to conduct the interview. Results: Two thirds (63%) of pharmacists managed oral problems nearly everyday, and 30% managed these more than once a week. More pharmacists in high SES (73%) areas managed oral problems nearly everyday (Fisher Exact, p=0.0005). Just over half (56%) and 49.2% of pharmacists said that ulcers and thrush, respectively, was the most common oral problem that they encounter. The prevalence of oral thrush was significantly higher in non-metro areas (58%) (RR=0.7 (0.5-1.0) ChiSquared=4.0, p=0.04), and it was also significantly lower in low SES areas (RR=1.6 (1.1-2.4), Chi Squared=6.5, p=0.01). Half the pharmacists reported that they would manage the patient comprehensively. Most would take a history but the quality of the history is poor, thereby compromising their ability to manage these cases appropriately. Only a third would refer a simple oral ulcer, thrush or mouth sore to a doctor/dentist but all pharmacists would have referred a longstanding ulcer to a doctor/dentist. In terms of knowledge, only 33% of pharmacists were aware that oral ulcers and thrush could be indicative of HIV infection, and only 8% linked oral ulcers with oral cancer. There was no discernable pattern of management of oral ulcers and thrush, or of knowledge of the link between these lesions with underlying diseases, by SES and metropolitan locations (Chi Squared, Fisher Exact, p>0.05). Conclusion: The result of this study strengthens the current view of pharmacists as oral health advisors as they encounter oral problems regularly, most commonly oral ulcers and oral thrush. Therefore, the pharmacist can play an important role in the early detection of HIV and oral cancer. However many pharmacists fail to refer these cases to a dentist. Most pharmacists lacked specific knowledge about the relationship of oral ulcers and thrush with underlying conditions, which may explain why many pharmacists are not managing these cases correctly. There is a definite need to train pharmacists at both an under- and post-graduate level with specific emphasis on the proper management of oral ulcers, oral thrush and mouth sores, as well as comprehensive training that outlines why vigilant management of oral ulcers and oral thrush is necessary.
South Africa
Ellis, Anna K., and L. Lee Glenn. "Challenges in Staging of Transient Pressure Ulcers Following Urologic Surgery." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etsu-works/7514.
Full textPlassmann, Peter. "Measuring area and volume of leg ulcers by structured light." Thesis, University of South Wales, 1992. https://pure.southwales.ac.uk/en/studentthesis/measuring-area-and-volume-of-leg-ulcers-by-structured-light(a5e9878a-c8d6-4933-b4d8-e6f3e7e480ce).html.
Full textHinkel, Brandon Jerome. "Microcapsule Containing Lactic Acid Bacteria for Treatment of Peptic Ulcers." DigitalCommons@CalPoly, 2013. https://digitalcommons.calpoly.edu/theses/967.
Full textFinlayson, Kathleen Joy. "Identification of factors contributing to recurrence of venous leg ulcers." Thesis, Queensland University of Technology, 2010. https://eprints.qut.edu.au/39531/1/Kathleen_Finlayson_Thesis.pdf.
Full textGonçalves, Marcia Beatriz Berzoti. "Impacto do ensino a distância no conhecimento dos docentes de enfermagem para avaliação de feridas crônicas." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/22/22132/tde-20052014-202245/.
Full textThe knowledge based on the best scientific evidence of care to people with chronic wounds (CW) should be the basis of this theme teaching in nursing education. Considering the epidemiological relevance of this problem, nursing faculty are faced with the challenge of teaching students how to look after people with this complication in different contexts of health care. The assessment of CW is critical to identify and describe the healing process and the selection of the best topical therapy. The effectiveness of E-learning (EL) strategy to update knowledge has been demonstrated in other studies. Therefore, the aim of this study was to identify the impact of e-learning on CW assessment knowledge of teachers and nurses involved with higher education. A prospective and quasi-experimental study was conducted with data collection before and after the intervention. After the board of ethics approval, teachers and nurses were invited to participate in the research. These teachers and nurses involved in higher education institutions, both public and private, teach theoretical subjects and or practices in nursing undergraduate courses in the municipality in the state of Sao Paulo. The sample consisted of 26 teachers and nurses who attended the update course \"Assessment of Chronic Wounds in Nursing Care\" offered through the Virtual Learning Environment (VLE) Moodle. Among participants, we identified an average age of 42.3 years (SD=9.56), and regarding gender, all subjects were female. The average teaching experience was 11.16 years (SD=8.02), 24 (92.3%) teachers reported teaching theoretical subjects and/or practices, of which 91.7% reported working with CW care in practice scenarios. The most widely used tool to search for information about \"chronic wounds\" was the internet. The increase in the percentage of correct answers after the intervention was statistically significant and the item with highest number of correct answers in both pre and posttests was \"Dimensioning the wound\", with better performance at the end of the course. The correlation between times of teaching experience and performance on the knowledge test was negative, and the association between the use of other strategies to knowledge update (such as exchange of experience among peers, participation in scientific events on the theme) was found to improved performance of the participants. The use of EL as a tool for educational intervention focused on disseminating recommendations for CW assessment positively impacted the acquisition of knowledge among participants. Adopting technologies for the improvement of nursing faculty\'s abilities had outcomes that may support education and generate changes in the clinical nursing practice
Mourad, Mohamad Mazen. "Prognostic indicators in the gravitational syndrome." Thesis, Cardiff University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317158.
Full textLeonard, Andrea Jane. "Studies on gastric mucosal defence against pepsins." Thesis, University of Newcastle Upon Tyne, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.346421.
Full textMackay, William Gordon. "Environmental reservoirs of Helicobacter pylori : an investigation into drinking water biofilms." Thesis, Robert Gordon University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301380.
Full textTollow, Philippa. "Quality of life and experiences of treatment in chronic leg ulcers." Thesis, University of Surrey, 2016. http://epubs.surrey.ac.uk/812348/.
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