Relevant bibliographies by topics / Ulcers

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Ulcers'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 August 2024

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Journal articles on the topic "Ulcers"

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Maksymchuk, D., V. Mamchych, and V. Maksymchuk. "Surgical treatment of complicated duodenal ulcers with different variants of their localization." Journal of Education, Health and Sport 11, no. 9 (September 30, 2021): 773–80. http://dx.doi.org/10.12775/jehs.2021.11.09.093.

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Purpose: To analyze and highlight the most effective methods of surgical treatment of complicated duodenal ulcer (DU) depending on its location. Material and methods. 86 patients underwent surgery for complicated combined pyloroduodenal ulcers. All patients with signs of gastrointestinal bleeding and perforation were examined according to clinical protocols. Patients were operated on by various surgical techniques depending on the location of DU. Further the analysis of different methods of surgical treatment of the pathology under study at its various localizations was carried out. Results. It has been established that in complicated combined pyloroduodenal ulcers with localization in the pyloric canal antrumectomy is the method of priority. If duodenum ulcer is complicated by bleeding, excision with pyloroplasty is the method of priority. Suture ulceration with pyloroplasty can be considered as an alternative method of treatment. It has been verified that in complicated duodenal ulcers, exteriorization and suturing of the ulcer have the lowest efficiency. The most frequently used method of duodenal ulcers of any localization treatment was excision of the ulcer with pyloroplasty. 6 (41.8 ± 0.053%).patients had been operated on by this method. In the second place in terms of universality was ulcer’s suturing with pyloroplasty - 22 patients or (25.5 ± 0.047%). The third was the method of exteriorization and suturing of ulcers, which accounted for 10 patients (11.6 ± 0.034%).
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Peetsalu, Margot, Ülle Kirsimägi, and Ants Peetsalu. "Giant Prepyloric Ulcer Haemorrhage: Patient Characteristics, Treatment, and Outcome in 2003–2012." Ulcers 2014 (April 10, 2014): 1–5. http://dx.doi.org/10.1155/2014/326065.

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The aim of the study was to characterize patients with giant prepyloric ulcer haemorrhage, their treatment, and outcome. The data for 929 peptic ulcer haemorrhage (PUH) patients were divided into three groups according to ulcer location: group I: 165 prepyloric ulcer patients, group II: 353 gastric ulcer patients, and group III: 411 duodenal ulcer patients. Among these groups giant ulcer (ulcer diameter ≥ 2 cm) haemorrhage cases were selected for the study and the data for group I were compared with the data for groups II and III. The study shows that the proportion of giant ulcers in all prepyloric ulcers was significantly 2.2 times lower compared with the proportion of giant ulcers in all gastric ulcers and 1.5 times lower than the proportion of giant ulcers in all duodenal ulcers. The share of surgical therapy for haemorrhages from giant prepyloric ulcers did not differ from the share of surgical therapy in the case of giant gastric ulcers but was 3.5 times lower than in the case of giant duodenal ulcers. Generally, treatment for PUH from giant prepyloric ulcers was successful not involving inhospital mortality.
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Kamada, Tomoari, Kiichi Satoh, Toshiyuki Itoh, Masanori Ito, Junichi Iwamoto, Tadayoshi Okimoto, Takeshi Kanno, et al. "Evidence-based clinical practice guidelines for peptic ulcer disease 2020." Journal of Gastroenterology 56, no. 4 (February 23, 2021): 303–22. http://dx.doi.org/10.1007/s00535-021-01769-0.

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AbstractThe Japanese Society of Gastroenterology (JSGE) revised the third edition of evidence-based clinical practice guidelines for peptic ulcer disease in 2020 and created an English version. The revised guidelines consist of nine items: epidemiology, hemorrhagic gastric and duodenal ulcers, Helicobacter pylori (H. pylori) eradication therapy, non-eradication therapy, drug-induced ulcers, non-H. pylori, and nonsteroidal anti-inflammatory drug (NSAID) ulcers, remnant gastric ulcers, surgical treatment, and conservative therapy for perforation and stenosis. Therapeutic algorithms for the treatment of peptic ulcers differ based on ulcer complications. In patients with NSAID-induced ulcers, NSAIDs are discontinued and anti-ulcer therapy is administered. If NSAIDs cannot be discontinued, the ulcer is treated with proton pump inhibitors (PPIs). Vonoprazan (VPZ) with antibiotics is recommended as the first-line treatment for H. pylori eradication, and PPIs or VPZ with antibiotics is recommended as a second-line therapy. Patients who do not use NSAIDs and are H. pylori negative are considered to have idiopathic peptic ulcers. Algorithms for the prevention of NSAID- and low-dose aspirin (LDA)-related ulcers are presented in this guideline. These algorithms differ based on the concomitant use of LDA or NSAIDs and ulcer history or hemorrhagic ulcer history. In patients with a history of ulcers receiving NSAID therapy, PPIs with or without celecoxib are recommended and the administration of VPZ is suggested for the prevention of ulcer recurrence. In patients with a history of ulcers receiving LDA therapy, PPIs or VPZ are recommended and the administration of a histamine 2-receptor antagonist is suggested for the prevention of ulcer recurrence.
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Wakiya, R., Y. Ushio, K. Ueeda, H. Shimada, S. Nakashima, M. Kato, T. Miyagi, et al. "POS1362 THE EFFICACY AND CYTOKINE PROFILES DURING TREATMENT WITH APREMILAST IN PATIENTS WITH BEHÇET ‘S DISEASE." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1020.1–1020. http://dx.doi.org/10.1136/annrheumdis-2022-eular.4181.

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BackgroundApremilast has been shown to be effective in patients with Behçet’s disease (BD) in domains other than oral ulcers; however, its long-term efficacy is yet to be determined. Although serum cytokine modulation by increasing intracellular cAMP levels has been suggested as a mechanism for the efficacy of apremilast on skin areas of psoriasis [1], the relationship between efficacy and cytokine on various domains in BD has not been fully investigated.ObjectivesThis study aims to evaluate the long-term clinical efficacy of apremilast in BD and its effect on serum cytokines.MethodsIn this study, patients with BD who received apremilast for active oral ulcers were included. For 12 months, the improvement rates of oral and genital ulcers, skin lesions, and arthritis were assessed every three months. Serum levels of cytokines, including interferon-gamma (IFN-γ), interleukin 10 (IL-10), and IL-17A were determined using Simple Plex (Protein Simple, CA, USA) at baseline and three months after apremilast treatment. Other cytokines, including tumor necrosis factor-alpha (TNF-a), IL-6, IL-8, and IL-23, were also measured in serum using a multiplex immunoassay (Luminex Assay, R&D Systems).ResultsFifteen patients were included in this study. Table 1 shows the characteristics of the patients who participated in this study. Oral ulcers disappeared in 66.7% and 92.3% of the patients after 3 and 6 months of apremilast treatment, respectively. Genital ulcers disappeared in all patients after 6 months of apremilast treatment and were maintained for 12 months. The efficacy of apremilast in oral ulcers could be divided between two groups: 8 patients in the oral ulcer remission group (OU-R group) whose oral ulcers completely disappeared after 3 months of apremilast administration and persisted for 1 year, and 7 patients in the oral ulcer non-remission group (OU-NR group) whose oral ulcers persisted after 3 months of apremilast treatment. Genital ulcers improved more rapidly in the OU-R group than in the OU-NR group, and completely disappeared within 3 months. Skin and joint lesions generally improved after 6 months, but recurred after 9 months.Table 1.Baseline characteristics of the studied patients with Behçet’s diseaseCharacteristicsN = 15Age (years), mean ± SD46.7 ± 13.0Sex (female), n (%)11 (73.3)Disease duration (years), mean ± SD10.4 ± 8.8Active Behçet’s disease manifestation at the time of enrollment, n (%) Oral ulcer15 (100) Genital ulcer5 (33.3) Skin lesion (erythema nodosum or pustules)10 (66.7) Arthralgia9 (60.0) Arthritis5 (33.3) Ocular involvement0 (0) Gastrointestinal involvement1 (6.7) Neurological involvement0 (0) Vascular involvement0 (0)SD, standard deviation; n, number.Serum cytokines could be analyzed in seven of the 15 cases. There was no significant association between serum baseline cytokine levels and the presence of lesions or severity of disease. Compared to baseline, TNF-α and IL-23 levels were significantly lower after apremilast treatment and IFN-γ levels were trending upwards; however, IL-6, IL-8, and IL-10 levels showed no constant trend (TNF-α and IL-23: p <0.05, IFN-γ: p = 0.078). In addition, the rate of decrease in serum IL-6, IL-10, and IL-23 levels was significantly greater in the OU-R group than in the OU-NR group (Figure 1). However, the rate of change in serum cytokines was not associated with efficacy of apremilast for skin lesions, arthralgia, or arthritis.Figure 1.The rate of change in serum interleukin (IL)-6, IL-10, and IL-23 levels up to 3 months after apremilast treatment in the oral ulcer remission group and the oral ulcer non-remission group.ConclusionApremilast has shown long-term efficacy in the treatment of oral and genital ulcers in patients with BD. The efficacy of apremilast against oral ulcers in BD may be attributed to its modulatory effect on serum cytokines as previously reported. Future exploratory studies for biomarkers associated with the presence of efficacy against genital ulcer and arthritis are needed.References[1]Gottlieb AB, Matheson RT, Menter AM, et al. J Drugs Dermatol. 2013;12:888-97.Disclosure of InterestsNone declared
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Rasajnam, Neethu, Sreejith Kalathummarathu, Shehadad Kammili, and Sreedevi Menon. "Clinical Outcome of Chronic Leg and Foot Ulcers Treated with Autologous Platelet Rich Fibrin." Journal of Evolution of Medical and Dental Sciences 11, no. 1 (January 13, 2022): 33–38. http://dx.doi.org/10.14260/jemds/2022/7.

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BACKGROUND Chronic leg and foot ulcers are a major health problem and leads to negative physical, social and psychological impact on patients and families. A high percentage of chronic ulcers do not adequately heal or quickly relapse with conventional treatment. They need advanced treatment modalities. Emerging cellular therapies such as platelet-rich concentrate therapy is an advanced modality. Platelet rich fibrin (PRF) is a second-generation platelet concentrate, consists of fibrin three-dimensional polymerized matrix, with the incorporation of platelets and leukocytes. The objective of the study was to assess clinical outcome of chronic leg and foot ulcers treated with autologous platelet rich fibrin. METHODS This prospective study included 30 patients with chronic leg or foot ulcers of various aetiologies, 19 patients had diabetic foot ulcers, 7 venous ulcers, 1 trophic ulcer, 2 pressure ulcers and 1 traumatic ulcer. Autologous PRF treatment outcome was measured by percentage of improvement in area and volume of the ulcer. We also studied other ulcer characteristics including exudate type, pus culture and sensitivity status, presence of undermining, type of tissue in ulcer bed and comorbidities. RESULTS From the 30 ulcers treated with PRF, the mean percentage of improvement in area and volume of ulcers were 98.3% and 98.8% respectively at the end of 2 months. 80% ulcers healed completely. There was also reduction of pain and exudate after first week of treatment. Other than increased callus formation in some ulcers, no other adverse events were reported following PRF treatment. CONCLUSIONS PRF is a safe, easy-to-use, cost-effective treatment method with significant potential for healing chronic ulcers. KEY WORDS PRF-Platelet Rich Fibrin
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Kulkarni, S. R., M. S. Gohel, M. R. Whyman, and K. R. Poskitt. "Significance of limb trauma as an initiating factor in chronic leg ulceration." Phlebology: The Journal of Venous Disease 23, no. 3 (June 2008): 130–36. http://dx.doi.org/10.1258/phleb.2007.007024.

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Objectives To assess differences in clinical outcomes between patients with traumatic and spontaneous leg ulcers. Methods Consecutive leg ulcer follow-up patients seen between April 2004 and October 2005 in a specialist leg ulcer clinic were asked about the mechanism of the original ulceration. Twenty-four-week healing and 12-month recurrence rates were calculated using Kaplan-Meier analysis and outcomes were compared between groups with traumatic and spontaneous ulcers. Results Of the 300 patients assessed, 38 were excluded (incomplete data). In the remaining 262 patients, cause of ulceration was traumatic in 116/262 (44%) and spontaneous in 146/262 (56%). Age, ankle brachial pressure index <0.85 and venous reflux were equally distributed between groups with traumatic and spontaneous ulcers ( P = 0.470, 0.793, 0.965 respectively, Chi-square test). Twenty-four-week healing rates were 81% for traumatic and 67% for spontaneous ulcers ( P = 0.015, Log-Rank test). Twelve-month recurrence rates were 32% for traumatic and 33% for spontaneous ulcers ( P = 0.970, Log-rank test). Patients with traumatic ulcers suffered a total of 53 ulcer recurrences (median 0, range 0–4) compared with 89 in patients with spontaneous ulcers (median 0, range 0–8) ( P < 0.001, Mann-Whitney U test). Conclusion Approximately half of all leg ulcer patients recall a traumatic event. When managed in leg ulcer clinic, traumatic ulcers heal faster and recur less frequently than spontaneous ulcers.
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Laborde, James M. "Midfoot Ulcers Treated with Gastrocnemius-Soleus Recession." Foot & Ankle International 30, no. 9 (September 2009): 842–46. http://dx.doi.org/10.3113/fai.2009.0842.

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Background: Foot ulcers in patients with neuropathy are a common cause of hospital admission for infection sometimes resulting in amputation in patients with neuropathy. Tendon lengthening alone has been reported to be successful in treating neuropathic forefoot ulcers. Tendon lengthening has also been recommended as an adjunct to bony procedures (exostectomy or fusion) for treating midfoot ulcers. The author reports the results of gastrocnemius-soleus recession as the sole treatment of diabetic midfoot ulcers. Materials and Methods: This study evaluated the results of 11 patients with 11 neuropathic plantar midfoot ulcers who were treated primarily with gastrocnemius-soleus recession with an average followup of 39 months. Potentially risky bony procedures were done after tendon lengthening if ulcers did not heal or recurred. Results: Ten of the ulcers healed but one patient was lost to followup after his ulcer healed. One ulcer did not heal and one ulcer recurred but healed again after midfoot fusion. One patient later had a transfemoral amputation due to gangrene. Two patients later died from medical problems unrelated to their surgery. There were no incision problems, or transfer ulcers. Conclusion: The author believes gastrocnemius-soleus recession as a primary treatment of diabetic midfoot ulcers is a low risk method of promoting ulcer resolution. Level of Evidence: IV, Retrospective Case Series
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Cheng, Hsiu-Chi, Hsiao-Bai Yang, Wei-Lun Chang, Wei-Ying Chen, Yi-Chun Yeh, and Bor-Shyang Sheu. "Expressions of MMPs and TIMP-1 in Gastric Ulcers May DifferentiateH. pylori-Infected from NSAID-Related Ulcers." Scientific World Journal 2012 (2012): 1–9. http://dx.doi.org/10.1100/2012/539316.

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Background. Two major causes of gastric ulcers areHelicobacter pylori(H. pylori) infection and nonsteroidal anti-inflammatory drug (NSAID) use.Aims. This study aimed to determine if there were different expressions of matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) betweenH. pylori-infected and NSAID-related ulcers.Methods. The 126 gastric ulcer patients (H. pyloriinfectedn=46; NSAID relatedn=30; combined with two factorsn=50) provided ulcer and nonulcer tissues for assessment of MMP-3, -7, and -9 and TIMP-1 expression by immunohistochemical staining.Results. Gastric ulcer tissues had significantly higher MMP-3, -7, and -9 and TIMP-1 expressions than nonulcer tissues (P<0.05).H. pylori-infected gastric ulcers had even higher MMP-7, MMP-9, and TIMP-1 expressions in epithelial cells than NSAID-related gastric ulcers (P<0.05). In patients with the two combined factors, gastric ulcers expressed similar proportions of antral ulcers and MMP-7 and MMP-9 intensities to NSAID-related gastric ulcers, but lower MMP-9 and TIMP-1 thanH. pylori-infected gastric ulcers (P<0.05).Conclusions. H. pylori-infected gastric ulcers express higher MMP-7, MMP-9, and TIMP-1 than NSAID-related ulcers. In patients with the two combined factors, ulcer location and MMP-7 and MMP-9 intensities are similar to NSAID use.
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Iamandii, Inga, Abram Beatrice Kouassi, Davide Simonazzi, Cristina Marchesi, Marco Vinceti, and Tommaso Filippini. "Healing Time of Skin Ulcers in Homecare Residents in the Province of Reggio Emilia, Northern Italy." Life 12, no. 12 (November 28, 2022): 1989. http://dx.doi.org/10.3390/life12121989.

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The growing phenomenon of skin ulcers represents an important health problem; therefore, we conducted a pilot study to evaluate the ulcer healing time among adult subjects followed by the Home Nursing Service of the AUSL-IRCCS of Reggio Emilia, Northern Italy, and diagnosed with at least one skin ulcer during the period of January–August 2020. We recruited 138 subjects (45.5% men) with a mean age of 86.1 years. The subjects presented with 232 ulcers, of which 76.7% were pressure ulcers (60.1% were stage II), 18.1% were vascular ulcers, and 4.7% were diabetic foot ulcers. Ulcer management required only one weekly access for the majority of subjects, with a recovery frequency of 53.6% at the end of the observation period. The median ulcer healing time was 3.6 months and was shorter in women (2.6 months) than men (5.1 months), with an increasing trend according to the number of ulcers and the severity of pressure ulcers for vascular and diabetic foot ulcers. In conclusion, this is the first study carried out in an Italian population describing the distribution and characteristics of homecare residents with skin ulcers and highlighting the factors influencing the healing time and as consequence the duration of nursing care.
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Lindholm, C., M. Bjellerup, O. B. Christensen, and B. Zederfeldt. "Leg and foot ulcers. Nursing care in Malmö, Sweden." Acta Dermato-Venereologica 72, no. 3 (January 1, 1992): 224–26. http://dx.doi.org/10.2340/0001555572224226.

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Questionnaires concerning nursing care of leg and foot ulcer patients in three major care-giving sectors of the national health service, namely the Department of Dermatology, general hospital wards/clinics, and primary care, have been analysed. The overall response rate was 88% (primary care: 100%). Forms regarding 193 patients with leg ulcers and 64 patients with foot ulcers were analysed. Substantial differences in nursing care were noted between the three sectors. In 55% of the leg ulcers and 45% of the foot ulcers fibrin slough was present in the ulcer. Black, necrotic tissue was present in 8% of the leg ulcers and 22% of the foot ulcers. Profuse ulcer-exudation was most commonly reported for leg ulcer patients treated at the Department of Dermatology, while the majority of foot ulcers had only a mild exudation. Frequency of dressing changes varied between 1.4 times/week for leg ulcers at the Department of Dermatology and 9.2 times/week (foot ulcers 11.6) at general hospital clinics. Local wound dressings were exclusively chosen by physicians at the Department of Dermatology, mainly by physicians at general hospital clinics, and equally often by physicians and nurses in primary care. Time since last evaluation of the ulcer by a physician varied. At the general hospital clinics, 89% of the patients with leg ulcers had been seen by a physician within the last 2-month period. At the Department of Dermatology, 89% and in primary care 61% of the patients were examined within this period. 11% of the patients in primary care had never consulted a physician for their ulcers.(ABSTRACT TRUNCATED AT 250 WORDS)
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Dissertations / Theses on the topic "Ulcers"

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Obogo, E., and E. Bassey. "Perforated duodenal ulcers associated with other complications of peptic ulcer disease." Thesis, Видавництво СумДУ, 2012. http://essuir.sumdu.edu.ua/handle/123456789/27515.

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Adriaans, Beverley. "The aetiology and pathogenesis of tropical ulcer." Master's thesis, University of Cape Town, 1988. http://hdl.handle.net/11427/25758.

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Tropical ulcer is a very specific form of cutaneous ulceration. It occurs worldwide in most tropical and a number of subtropical areas. The disease occurs mainly in older children and young adults with children under the age of 5 and adults over 45 years rarely being affected. Ulcers occur most commonly on the lower leg but may occur on the upper limb. Although most ulcers normally heal slowly over many weeks or months, some ulcers may recur. Recognised complications include squamous cell carcinoma, gangrene and osteitis, although these are rare. A number of authors have reported on the disease and suggested diet, trauma and infection as aetiological factors for this condition. This survey was thus conducted to assess as many of these factors as possible. The study took place in 5 tropical areas, namely Zambia, Gambia, southern India, Fiji and Papua New Guinea. Consultations took place at hospitals, rural clinics, health centres and villages. Although many authors have suggested that the disease is related to malnutrition, few have objectively assessed the nutritional status of the patients and compared it with controls. Those studies which included objective assessments were limited to small areas and only investigated specific parameters. In order to investigate the immune response of the host to an anaerobic infection, the antibody levels to the organisms isolated from the ulcers were measured by an ELISA test. The local host response to an infection with a Fusobacterium species was assessed by the number of antibody secreting B-lymphocytes at the site of the ulcers. These parameters may play a role in the localisation of the ulcers and account for recurrent infections.
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Loots, Miriam Alfonsa Maria. "Wound healing in diabetic ulcers." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2002. http://dare.uva.nl/document/66897.

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Sahin, Birnur. "DEVA : Treating Chroinic Leg Ulcers." Thesis, Umeå universitet, Designhögskolan vid Umeå universitet, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-172613.

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An ulcer is an open wound that remains unhealed even after weeks of treatment. These types of wounds require a long process of treatment due to other underlying health problems. Having an unhealing, painful and often infected wound decreases patients’ life quality significantly. The treatment includes using wound dressing applied by nurses, to protect the wound from infections, collect exudate and provide a closed and sterile environment. During a treatment, which could last for months, patients experience a lot of emotional and physical challenges. Deva is a design concept proposing the use of smart sensors in wound care treatment in a way that it will improve the communication between patients and nurses, by providing information and guidance. The ecosystem consists of a smart wound patch that will turn any wound dressing today into a “smart” one, an electrostimulation therapy sock and digital platforms where the information will be available. This way information on the wound status will be available for the patient, their family members or caregivers and the nurses.This project has been developed by interviewing nurses and wound care professionals from Turkey, Sweden and Denmark. The insights reflect the situation and the healthcare system in these countries and a wound care treatment journey might differ in other settings.
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Angelis, Célio Damacena de [UNESP]. "Avaliação da proteção gástrica e duodenal do monoterpeno nerol em roedores." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/91622.

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Este projeto se propôs a avaliar a ação farmacológica do nerol na prevenção de úlcera péptica. Nerol na dose de 60 mg/Kg por via oral exerceu proteção contra lesão gástrica induzida por etanol e por droga anti-inflamatória não esteróide (DAINE) em ratos, mas não protegeu contra úlcera duodenal induzida por cisteamina. Experimentos foram realizados para a elucidação dos mecanismos ação e verificou-se que a proteção exercida pelo Nerol não é por bloqueio dos radicais livres, por redução da secreção gástrica ou por aumento de muco, sua ação também não ocorre por formação de barreira mecânica. Verificou-se, contudo, que houve redução da motilidade gastrointestinal, o que pode ser um indicativo de redução do esvaziamento gástrico, o que contribui para o efeito gastroprotetor. A redução da motilidade gastrointestinal assim como a redução do acúmulo intestinal exercido pelo nerol foi revertida pela administração de naloxona (antagonista de receptores opióides), indicando, portanto, o envolvimento destes receptores. Através do bloqueio de fatores protetores da mucosa gástrica, verificou-se que a gastroproteção exercida pelo nerol é independente da via do óxido nítrico, de prostaglandinas e dos receptores mu opióides, porém, é dependente de compostos sulfidrílicos. Mostrou-se através da quantificação dos níveis de glutationa (GSH) e da atividade da enzima mieloperoxidase (MPO) que o tratamento com nerol mantém os níveis de compostos sulfidrílicos não-protéicos e reduz a infiltração de neutrófilos na mucosa gástrica em animais com lesão gástrica induzida por etanol. A administração aguda de nerol (doses de 60, 300, 600, 1250, 2500 ou 5000 mg/Kg) não provocou mortes nem alterações significantes nos parâmetros comportamentais até a dose de 600 mg/Kg. Neste trabalho portanto, ficou...
The present project proposed to evaluate the pharmacologic action of nerol in the prevection of peptic ulcer. It was seen that 60 mg/kg (p.o.) of nerol prevented gastric lesions induced by ethanol and no steroidal anti-inflammatory drugs (NSAID) in rats, however nerol did not have protected duodenal mucosa against cysteamine. Assays were performed to elucidation of the mechanisms of action and it was found that protection exerted by Nerol does not by block of free radicals, nor decrease gastric acid secretion nor increase mucus, its action is not by create a mechanical barrier. However It was found that nerol reduced gastrointestinal motility, this might be an indicative of slower gastric emptying that contribute to the gastric protective effect. Reduction of gastrointestinal motility, as well as the reduction of intestinal accumulation exerted by nerol was reverted by naloxone administration (antagonist of opioid receptors), therefore indicating involvement of the cited receptors. By blocking protective factors of gastric mucosa, it was verified that nerol’s gastroprotective effect does not involve nitric oxide, prostaglandin nor mu opioid receptors, but is dependent of sulfhydryl compounds. It was shown by quantifying glutathione levels (GSH) and myeloperoxidase (MPO) action that treatment with nerol keeps the levels of non proteic sulfhydryl compounds and decreases the neutrophil infiltration into the gastric mucosa in animals with ethanol-induced gastric damage. Acute administration of nerol (60, 300, 600, 1250, 2500 and 5000 mg/Kg) presented no deaths, neither significant behavior changes to doses of 60, 300 and 600 mg/kg. In this work, nerol showed a gastroprotective effect against ethanol- and indomethacin-induced lesions, and the depence of sulfhydryl compounds. The involvement of opioid receptors and the gastrointestinal... (Complete abstract click electronic access below)
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Silva, Laísa Pinheiro da [UNESP]. "Avaliação dos mecanismos de ação envolvidos nas atividades antiulcerogênica e cicatrizante do extrato etanólico obtido a partir das folhas de Terminalia catappa L. (COMBRETACEAE)." Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/91639.

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Terminalia catappa Linn é uma espécie comumente utilizada para arborização nas regiões tropical e subtropical. Essa espécie é também utilizada, em países da Ásia, como Taiwan, Índia, Flipinas e Indonésia, para tratamento de distúrbios hepáticos e do trato gastrointestinal. A literatura aponta que seus constituintes encontrados nos extratos polares das folhas são principalmente compostos polifenólicos, em especial os taninos. A partir desses dados e da ausência de registros na literatura sobre a ação antiulcerogênica desta espécie foram realizados estudos para avaliação dessa atividade das frações e caracterização da fração mais ativa, assim como a determinação do mecanismo de ação gastroprotetor e cicatrizante da fração ativa. A partir do extrato etanólico bruto das folhas, que em estudo anterior realizado pelo grupo demonstrou atividade gastroprotetora, antisecretória e cicatrizante, foi feita a partição com três solventes de diferentes polaridades (hexano, acetato de etila e metanol/água). As três frações oriundas destas extrações apresentaram ação gastroprotetora em úlcera induzida por etanol absoluto, porém a fração mais efetiva foi a aquosa na dose de 25 mg/Kg, selecionada para caracterizar os mecanismos de ação envolvidos na ação antiulcerogênica como: óxido nítrico (NO), prostaglandinas (PG), aumento de muco e atividade antioxidante por meio da manutenção dos níveis de glutationa e redução da atividade da enzima mieloperoxidase (MPO). Não foram observadas a participação dos grupamentos sulfidrila e ação antisecretória. Foi constatada atividade cicatrizante tanto com 7 como com 14 dias de tratamento, consecutivos, da fração aquosa. Durante o tratamento com a partição aquosa ocorreu uma...
Terminalia catappa Linn is a specie commonly used for afforestation in tropical and subtropical regions. It is used, in Asian countries, as Taiwan, India, Filipines and Indonesia, for treatment of hepatic and gastrointestinal disorders. Studies point to poliphenols as main components of polar leaves extract, specially the tannins. Based on this and in the lack of information about a possible gastroprotective action of this specie, studies for avaliation of this activity were done with fractions of the ethanolic extract, and gastroprotective action mechanisms were characterized in the most active fraction. A previous study done by our group showed the ethanolic extract as gastroprotective, antisecretory and healing. The ethanol extract were partitioned with three different solvents, hexane, etil acetate and methanol/water. The three fractions showed gastroprotective action in the model of ulcer induced by ethanol, but the most effective was aquous fraction in a dose of 25 mg/Kg, which was the one selected to the characterization of the mechanisms involved in the antiulcerogenic activity as: nitric oxide (NO), prostaglandins (PG), mucus and antioxidant activity by maintenance of glutathione levels and reduction in mieloperoxidase (MPO) enzyme activity. No participation of sulphidryls compounds and antisecretory activity were detected. The aquous fraction also showed healing action in the treatment for 7 and 14 days, in both of them was detected a down-regulation in metalloproteinase-2 (MPP-2). In a subchronic toxicity avaliation, the aquous fraction in 25 mg/Kg doesn´t presented a toxic potential. In the model of gastric ulcer induced by indomethacin, the aquous fraction in a dose of 50 mg/Kg, aggravated the lesions, which showed an evidence for antiinflamatory activity, it was confirmed in Formalin test and ear edema induced by... (Complete abstract click electronic access below)
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Silva, Laísa Pinheiro da. "Avaliação dos mecanismos de ação envolvidos nas atividades antiulcerogênica e cicatrizante do extrato etanólico obtido a partir das folhas de Terminalia catappa L. (COMBRETACEAE) /." Botucatu : [s.n.], 2012. http://hdl.handle.net/11449/91639.

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Orientador: Clélia Akiko Hiruma-Lima
Banca: Wagner Villegas
Banca: Walter Toma
Resumo: Terminalia catappa Linn é uma espécie comumente utilizada para arborização nas regiões tropical e subtropical. Essa espécie é também utilizada, em países da Ásia, como Taiwan, Índia, Flipinas e Indonésia, para tratamento de distúrbios hepáticos e do trato gastrointestinal. A literatura aponta que seus constituintes encontrados nos extratos polares das folhas são principalmente compostos polifenólicos, em especial os taninos. A partir desses dados e da ausência de registros na literatura sobre a ação antiulcerogênica desta espécie foram realizados estudos para avaliação dessa atividade das frações e caracterização da fração mais ativa, assim como a determinação do mecanismo de ação gastroprotetor e cicatrizante da fração ativa. A partir do extrato etanólico bruto das folhas, que em estudo anterior realizado pelo grupo demonstrou atividade gastroprotetora, antisecretória e cicatrizante, foi feita a partição com três solventes de diferentes polaridades (hexano, acetato de etila e metanol/água). As três frações oriundas destas extrações apresentaram ação gastroprotetora em úlcera induzida por etanol absoluto, porém a fração mais efetiva foi a aquosa na dose de 25 mg/Kg, selecionada para caracterizar os mecanismos de ação envolvidos na ação antiulcerogênica como: óxido nítrico (NO), prostaglandinas (PG), aumento de muco e atividade antioxidante por meio da manutenção dos níveis de glutationa e redução da atividade da enzima mieloperoxidase (MPO). Não foram observadas a participação dos grupamentos sulfidrila e ação antisecretória. Foi constatada atividade cicatrizante tanto com 7 como com 14 dias de tratamento, consecutivos, da fração aquosa. Durante o tratamento com a partição aquosa ocorreu uma... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Terminalia catappa Linn is a specie commonly used for afforestation in tropical and subtropical regions. It is used, in Asian countries, as Taiwan, India, Filipines and Indonesia, for treatment of hepatic and gastrointestinal disorders. Studies point to poliphenols as main components of polar leaves extract, specially the tannins. Based on this and in the lack of information about a possible gastroprotective action of this specie, studies for avaliation of this activity were done with fractions of the ethanolic extract, and gastroprotective action mechanisms were characterized in the most active fraction. A previous study done by our group showed the ethanolic extract as gastroprotective, antisecretory and healing. The ethanol extract were partitioned with three different solvents, hexane, etil acetate and methanol/water. The three fractions showed gastroprotective action in the model of ulcer induced by ethanol, but the most effective was aquous fraction in a dose of 25 mg/Kg, which was the one selected to the characterization of the mechanisms involved in the antiulcerogenic activity as: nitric oxide (NO), prostaglandins (PG), mucus and antioxidant activity by maintenance of glutathione levels and reduction in mieloperoxidase (MPO) enzyme activity. No participation of sulphidryls compounds and antisecretory activity were detected. The aquous fraction also showed healing action in the treatment for 7 and 14 days, in both of them was detected a down-regulation in metalloproteinase-2 (MPP-2). In a subchronic toxicity avaliation, the aquous fraction in 25 mg/Kg doesn't presented a toxic potential. In the model of gastric ulcer induced by indomethacin, the aquous fraction in a dose of 50 mg/Kg, aggravated the lesions, which showed an evidence for antiinflamatory activity, it was confirmed in Formalin test and ear edema induced by... (Complete abstract click electronic access below)
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Angelis, Célio Damacena de. "Avaliação da proteção gástrica e duodenal do monoterpeno nerol em roedores /." Botucatu, 2012. http://hdl.handle.net/11449/91622.

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Orientador: Clélia Akiko Hiruma-Lima
Banca: Elfriede Marianne Bacchi
Banca: Luiz Claudio Di Stasi
Resumo: Este projeto se propôs a avaliar a ação farmacológica do nerol na prevenção de úlcera péptica. Nerol na dose de 60 mg/Kg por via oral exerceu proteção contra lesão gástrica induzida por etanol e por droga anti-inflamatória não esteróide (DAINE) em ratos, mas não protegeu contra úlcera duodenal induzida por cisteamina. Experimentos foram realizados para a elucidação dos mecanismos ação e verificou-se que a proteção exercida pelo Nerol não é por bloqueio dos radicais livres, por redução da secreção gástrica ou por aumento de muco, sua ação também não ocorre por formação de barreira mecânica. Verificou-se, contudo, que houve redução da motilidade gastrointestinal, o que pode ser um indicativo de redução do esvaziamento gástrico, o que contribui para o efeito gastroprotetor. A redução da motilidade gastrointestinal assim como a redução do acúmulo intestinal exercido pelo nerol foi revertida pela administração de naloxona (antagonista de receptores opióides), indicando, portanto, o envolvimento destes receptores. Através do bloqueio de fatores protetores da mucosa gástrica, verificou-se que a gastroproteção exercida pelo nerol é independente da via do óxido nítrico, de prostaglandinas e dos receptores mu opióides, porém, é dependente de compostos sulfidrílicos. Mostrou-se através da quantificação dos níveis de glutationa (GSH) e da atividade da enzima mieloperoxidase (MPO) que o tratamento com nerol mantém os níveis de compostos sulfidrílicos não-protéicos e reduz a infiltração de neutrófilos na mucosa gástrica em animais com lesão gástrica induzida por etanol. A administração aguda de nerol (doses de 60, 300, 600, 1250, 2500 ou 5000 mg/Kg) não provocou mortes nem alterações significantes nos parâmetros comportamentais até a dose de 600 mg/Kg. Neste trabalho portanto, ficou... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The present project proposed to evaluate the pharmacologic action of nerol in the prevection of peptic ulcer. It was seen that 60 mg/kg (p.o.) of nerol prevented gastric lesions induced by ethanol and no steroidal anti-inflammatory drugs (NSAID) in rats, however nerol did not have protected duodenal mucosa against cysteamine. Assays were performed to elucidation of the mechanisms of action and it was found that protection exerted by Nerol does not by block of free radicals, nor decrease gastric acid secretion nor increase mucus, its action is not by create a mechanical barrier. However It was found that nerol reduced gastrointestinal motility, this might be an indicative of slower gastric emptying that contribute to the gastric protective effect. Reduction of gastrointestinal motility, as well as the reduction of intestinal accumulation exerted by nerol was reverted by naloxone administration (antagonist of opioid receptors), therefore indicating involvement of the cited receptors. By blocking protective factors of gastric mucosa, it was verified that nerol's gastroprotective effect does not involve nitric oxide, prostaglandin nor mu opioid receptors, but is dependent of sulfhydryl compounds. It was shown by quantifying glutathione levels (GSH) and myeloperoxidase (MPO) action that treatment with nerol keeps the levels of non proteic sulfhydryl compounds and decreases the neutrophil infiltration into the gastric mucosa in animals with ethanol-induced gastric damage. Acute administration of nerol (60, 300, 600, 1250, 2500 and 5000 mg/Kg) presented no deaths, neither significant behavior changes to doses of 60, 300 and 600 mg/kg. In this work, nerol showed a gastroprotective effect against ethanol- and indomethacin-induced lesions, and the depence of sulfhydryl compounds. The involvement of opioid receptors and the gastrointestinal... (Complete abstract click electronic access below)
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9

Debacker, Martine M. J. "L'ulcère de Buruli dans un centre de santé rural au Bénin." Doctoral thesis, Universite Libre de Bruxelles, 2005. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211042.

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Notre travail porte sur tous les cas UB enregistrés entre 1997 et 2003 au Centre Sanitaire Nutritionnel Gbemoten (CSNG) de Zagnanado dans la région du Zou au Bénin. Une base de données a été créée et a permis d’analyser divers aspects de l’UB. Ces analyses ont donné lieu à diverses publications dont les résultats essentiels sont repris ci-dessous.

Une première publication porte sur 1700 cas consécutifs admis au CSNG entre 1997 et 2001. Ces données nous ont permis d’illustrer l’évolution du nombre des cas d’UB au cours des années, par département et par sous-préfecture. Le nombre de patients UB qui se présentent au centre est fonction de différents facteurs comme par exemple l’ouverture d’autres centres de traitement, l’organisation de campagnes d’information sur l’UB mais aussi de changements dans l’environnement. Au niveau des formes de la maladie, nous avons montré que les formes non ulcérées sont aussi fréquentes que les formes ulcérées. La forme de la maladie est liée au délai à consulter le CSNG. Les atteintes osseuses sont fréquentes et sont présentes chez plus de 13% des cas. Au fil des années, le délai à consulter le CSNG ainsi que la durée de l’hospitalisation ont été fortement réduits, passant de 4 mois à 1 mois dans le premier cas et de 9 mois à 1 mois en ce qui concerne l’hospitalisation. Les personnes ressources à cibler lors des campagnes de sensibilisation sur la maladie ont été identifiées. Il s’agit des anciens malades, qui dans 68% des cas, réfèrent les nouveaux malades au CSNG.

Une deuxième publication, portant sur la même période, nous a permis de mettre en évidence pour la première fois des taux d’UB élevés chez les sujets de 60 ans et plus, probablement du fait d’une diminution de leur immunité. Chez les 60 ans et plus, les hommes sont plus à risque de développer un UB que les femmes. Par contre aucune différence dans le risque d’UB en fonction du sexe n’est trouvée chez les moins de 60 ans. Les lésions d’UB prédominent au niveau des membres inférieurs pour tous les groupes d’âge. Du fait de leur petite stature, les enfants ont une répartition des lésions qui touchent tout le corps. Chez les adultes, les femmes présentent plus de lésions que les hommes au niveau de la tête, du cou et du tronc. Les sujets de moins de 15 ans développent souvent des lésions multifocales, associées à des atteintes osseuses. Ces atteintes osseuses constituent les formes graves de la maladie.

Notre troisième publication porte sur le suivi des malades au niveau des villages, entre mars 2000 et février 2001, afin de déterminer les taux de récurrences de l’UB. Le taux de récurrence de la maladie est faible (6.1%) pour un temps de suivi des malades allant jusqu’à 7 ans. La majorité des malades soignés au CSNG étaient en bonne santé. Nous n’avons néanmoins pu retrouver qu’un nombre limité de malades.

Dans notre quatrième publication, nous avons pu mettre en évidence le développement d’un UB sur le site d’une morsure humaine. La surface de la peau du malade a pu être contaminée par M. ulcerans et la morsure (= traumatisme) a occasionné l’entrée de M. ulcerans dans le derme. Une autre explication plausible est que la morsure ait réactivé un foyer latent de M. ulcerans au niveau du site de la morsure.

Notre base de données nous a également permis de contribuer à d’autres études, notamment celles sur l’influence du BCG et de la schistosomiase sur l’UB. Dans les deux cas, nous trouvons une association significative avec les formes graves de l’UB, l’absence de vaccination BCG et la schistosomiase favorisant le développement de formes osseuses. Aucun lien n’a pu être établi entre la présence ou l’absence de l’infection à Schistosoma haematobium et l’UB.

Dans la dernière partie de notre travail, nous nous sommes attachés à l’étude de quelques facteurs de risque de l’UB. Nous avons montré que l’UB est essentiellement associé à l’âge, le lieu de résidence et le type d’eau utilisé. Pour les sujets de 5 ans et plus, le risque d’UB est plus élevé chez les sujets vaccinés à la naissance avec le BCG. L’analyse par strate d’âge des sujets âgés de 5 ans et plus, nous a permis de voir que dans le groupe des 50 ans et plus l’influence du type d’eau utilisé est moindre que dans les autres groupes d’âge, laissant envisager qu’un autre facteur entre en jeu :une réactivation de la maladie à la faveur d’une baisse d’immunité.

Notre étude démontre que la prise en charge de l’UB doit être pluridisciplinaire et doit pouvoir englober diverses interventions telles que :

- les campagnes d’information à la population,

- la formation du personnel sanitaire ainsi qu’une implication de l’état,

- une bonne prise en charge des malades au niveau des centres de traitement de l’UB en collaboration avec les laboratoires régionaux et internationaux,

- la confirmation microbiologique des cas,

- la mise en place d’un suivi des malades en s’appuyant sur les structures déjà mises en place pour d’autres maladies,

- la mise à disposition des populations de sources d’eau potable (puits, pompes) qui par la même occasion permettront de limiter/diminuer d’autres affections liées à la consommation d’eau non potable,

- la poursuite des activités de recherche sur un éventuel vaccin ou une médication appropriée, ainsi que sur le réservoir de M. ulcerans afin de pouvoir mettre en place des stratégies de prévention de la maladie.


Doctorat en Sciences de la santé publique
info:eu-repo/semantics/nonPublished

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Tuttle, Marie S. "Microbial Bioburden in Venous Leg Ulcers." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1409912389.

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Books on the topic "Ulcers"

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Danijel, Erceg, and Milojeviæ Pero, eds. Ulcers: Causes, diagnosis, and treatment. Hauppauge, NY: Nova Science Publishers, 2009.

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Fenner, Louise. When digestive juices corrode, you've got an ulcer. Rockville, Md: Dept. of Health and Human Services, Public Health Service, Food and Drug Administration, 1987.

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RNT, Harper Peter RGN, ed. Leg ulcers. New York: Churchill Livingstone, 1997.

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Inc, Biomedical Business International, ed. Pressure ulcers. Santa Ana, CA: Biomedical Business International, 1990.

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1927-, Bergan John J., and Shortell Cynthia K, eds. Venous ulcers. Amsterdam: Elsevier Academic Press, 2007.

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Halpern, Georges M. Ulcer free!: Nature's safe & effective remedy for ulcers. Garden City Park, N.Y: Square One Publishers, 2004.

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United States. Treatment of Pressure Ulcers Guideline Panel. Treating pressure ulcers. Rockville, Md: U.S. Dept. of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, 1996.

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United States. Treatment of Pressure Ulcers Guideline Panel. Treating pressure ulcers. Rockville, Md: U.S. Dept. of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research, 1996.

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Patrias, Karen. Therapeutic endoscopy and bleeding ulcers: January 1980 through December 1988 : 491 citations. Bethesda, Md: U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine, Reference Section, 1989.

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E, Hernandez Daniel, Glavin Gary B, New York Academy of Sciences., University of Southern California. School of Medicine. Postgraduate Division., and International Conference: Biology of Stress Ulcers (1988 : Lake Arrowhead, Calif.), eds. Neurobiology of stress ulcers. New York, N.Y: New York Academy of Sciences, 1990.

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Book chapters on the topic "Ulcers"

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Theisler, Charles. "Ulcers—Pressure Ulcers/Decubitus Ulcers/Bedsores." In Adjuvant Medical Care, 348–49. New York: CRC Press, 2022. http://dx.doi.org/10.1201/b22898-339.

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Happ, Carrie. "Ulcers." In Encyclopedia of Ophthalmology, 1–3. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-35951-4_938-1.

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Happ, Carrie. "Ulcers." In Encyclopedia of Ophthalmology, 1864–66. Berlin, Heidelberg: Springer Berlin Heidelberg, 2018. http://dx.doi.org/10.1007/978-3-540-69000-9_938.

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Beeckman, Dimitri, Nele Van Damme, Dorien De Meyer, and Karen Van den Bussche. "Pressure Ulcers." In Practical Issues in Geriatrics, 179–89. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-61997-2_19.

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Philipone, Elizabeth, and Angela J. Yoon. "Oral Ulcers." In Oral Pathology in the Pediatric Patient, 33–60. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-44640-0_3.

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Forciea, Mary Ann. "Pressure Ulcers." In Classic Papers in Geriatric Medicine with Current Commentaries, 145–51. Totowa, NJ: Humana Press, 2008. http://dx.doi.org/10.1007/978-1-59745-428-5_14.

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Mutasim, Diya F. "Leg Ulcers." In Practical Skin Pathology, 103–7. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14729-1_22.

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Janson, Ben. "Corneal Ulcers." In Encyclopedia of Ophthalmology, 1. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-35951-4_722-1.

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Streit, Markus, and Claudia Blazek. "Leg Ulcers." In European Handbook of Dermatological Treatments, 475–94. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-662-45139-7_49.

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Dhillon, Ramindar S., and James W. Fairley. "Mouth ulcers." In Multiple-choice Questions in Otolaryngology, 180. London: Palgrave Macmillan UK, 1989. http://dx.doi.org/10.1007/978-1-349-10805-3_266.

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Conference papers on the topic "Ulcers"

1

Gierasimovič, Zita, and Zyta Kuzborska. "Assessment of the effectiveness of pressure ulcer care." In Biomdlore. VGTU Technika, 2016. http://dx.doi.org/10.3846/biomdlore.2016.04.

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The article deals with the external and internal factors influencing development of pressure ulcers and the effectiveness of their care. The patients were assessed according to their age, gender and changes in their condition. The modified Norton Scale was used to assess the effectiveness of pressure ulcer care. It has been established that internal factors increase the risk of developing pressure ulcers. The effectiveness of pressure ulcer care is promoted by pressure ulcers preventative measures, medicines and skin hygiene.
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Bronneberg, Debbie, Lisette H. Cornelissen, Cees W. J. Oomens, Frank P. T. Baaijens, and Carlijn V. C. Bouten. "Cytokine and Chemokine Release Upon Sustained Mechanical Loading of the Epidermis." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176103.

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Pressure ulcers are areas of soft tissue breakdown resulting from sustained mechanical loading of the skin and underlying tissues. These ulcers are painful, difficult to treat, and represent a burden to the community in terms of health care and money. Currently, pressure ulcer risk assessment is dominated by subjective measures and does not predict pressure ulcer development satisfactorily [1]. Objective measures are therefore needed for early, non-invasive detection.
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Buchón-Moragues, Fernando, David Sánchez-Jiménez, Jesús Palomar-Vázquez, and Guillermo Peris-Fajarnés. "PROCESAMIENTO AUTOMATIZADO DE MODELOS TRIDIMENSIONALES DE ÚLCERAS CUTÁNEAS." In 1st Congress in Geomatics Engineering. Valencia: Universitat Politècnica València, 2017. http://dx.doi.org/10.4995/cigeo2017.2017.6553.

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Geomatics includes techniques such as photogrammetry, remote sensing and geographic information systems, which provide applicable tools in various areas of biomedicine, for example skin ulcer measurement. In previous projects we developed procedures for acquiring data and measuring skin ulcers using a digital photo camera, a manual scanner and photogrammetry software based on correlation. We have tested our technique in a randomized clinical trial in patients with chronic leg ulcers. In the present project an application system is created with the following objectives: automate the processing of three-dimensional models of cutaneous ulcers and generate documentation that ease the interpretation of the evolution of skin ulcers by medical personnel (including PDF report, AVI animation and XOS augmented reality project). We also created a website prototype that stores the documentation, allowing registered users to upload photographs and consult or modify the database of skin ulcers. A test is performed with 50 cutaneous leg ulcers, in order to debug and improve the application system and the website prototype.http://dx.doi.org/10.4995/CIGeo2017.2017.6553
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Russo, Lea, Mihir Gondhalekar, Sridhar Kota, and Benjamin Bassin. "A Device for Reducing Pressure Ulcers in Bedridden Patients Using Fiber Reinforced Elastomeric Enclosures (FREEs)." In ASME 2022 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/imece2022-95255.

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Abstract This paper describes the design, development, and prototype testing of a device that can relieve contact pressure to potentially prevent pressure ulcers in bedridden patients by utilizing pneumatically actuated Fiber-Reinforced Elastomeric Enclosures (FREEs) [1,2]. Bedsores, or pressure ulcers, develop in bedridden patients due to constant contact pressure between a patient’s skin and an external (bed) surface. It is estimated that over 2.5 million patients [8] suffer from pressure ulcer developments annually in the United States. High pressure areas of the body include the sacrum and heel, with 36% of pressure ulcers occurring at the sacrum and 30% occurring at the heel. All other body areas each account for only 6% of pressure ulcer occurrence [6]. They are a major concern for low-mobility, patients who are bedridden for an extended periods and are associated with a 5x increase in patient mortality [3]. In addition, pressure ulcers place a significant cost burden on patients. Development of Stage 4 pressure ulcers and associated comorbidities can cost on average $127,000 to the patient [4]. This high cost is mainly due to attending caregiver’s time. The most common solution for preventing the development of pressure ulcers in bed ridden hospital patients is for the attending nurses to reposition the patients every 2 hours so that the affected areas are relieved of any contact pressure. Repositioning patients is time consuming and strenuous for health care providers. General purpose “dynamic” pressure relief mattresses have shown to be somewhat effective in reducing the development of pressure ulcers. However, they do not effectively target high pressure areas and still necessitate frequent repositioning. FREEs can be designed to generate a variety of shapes and motions once actuated (pressurized) and serve as building blocks for soft robotic applications. When FREEs, arranged in parallel, are embedded in a material with compatible elastic properties they propagate their deformed shape throughout the surface. These compliant sheets of FREEs are capable of sustaining loads while relieving pressure on high pressure areas of the body. The prototype for the device presented in this paper was designed for relieving pressure on a patient’s heel area. Preliminary test results demonstrate that the prototype device is effective at lifting a patient’s ankle, for patients weighing up to 250lbs, thus relieving contact pressure. The research also demonstrates the viability of developing modular pressure-relieving pads embedded with more advanced FREEs than described in this paper that can be tailored to relieve contact pressure on other affected areas such as the sacrum.
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Brakefield, Timothy, Thomas Burkhardt, Andrew Meehan, Gregory Nemunaitis, Mohamed Samir Hefzy, and Mehdi Pourazady. "Gurney Mattress Redesign." In ASME 2012 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/sbc2012-80036.

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One of the most devastating yet survivable injuries today is trauma to the spinal cord. Often times this injury results in the inability of the patient to move and feel below the neck. When transporting these individuals on a gurney to perform routine tests, they are prone to excessive pressures over long periods of time that may result in the breakdown of skin, muscle and other tissues over pressure sensitive areas resulting in the formation of pressure ulcers [1]. The financial burden to treat pressure ulcers is high. The cost to heal a single complex full-thickness pressure ulcer has been estimated to be $70,000 [2] and the total economic burden of treating all pressure ulcers was estimated to be as high as $1.335 billion per year [3]. These costs not only load society with an enormous financial burden, but the patient must undergo a series of treatments that may last for months which will remove them from productive activities.
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Erdemir, Ahmet. "Role of Patient Specifics on Mechanical Risk and Load Relief During Support of Bony Prominences." In ASME 2013 Conference on Frontiers in Medical Devices: Applications of Computer Modeling and Simulation. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/fmd2013-16034.

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Prolonged mechanical loading of tissue in between a bony prominence and a support surface can lead to pressure ulcers. Despite recent initiatives to curb down incidence rates, the health care burden of pressure ulcer prevention remains significant [1]. Etiology of pressure ulcers are commonly attributed to interface pressures. As a result, interventions, e.g., support surfaces, routinely aim to reduce contact pressures. However, the clinical effectiveness of such an objective can be questionable [2]. Recent studies have shown that internal mechanics of the tissue can be associated with pressure ulcer development [3], potentially indicating the inefficacy of interventions targeted solely at contact pressure relief. Tissue characteristics at a bony prominence, e.g., tissue thickness and material properties, also influence load distribution within and on the surface of the tissue. Given the variability in patient populations and for a bony region of interest [4], it is possible that patient specific risk and load relief (with the use of support surface) may differ widely.
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Geerligs, M., G. W. M. Peters, C. W. J. Oomens, P. Ackermans, and F. P. T. Baaijens. "Mechanical Behaviour of the Subcutaneous Fat Layer." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176364.

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A very important function of the human subcutaneous fat layer is to act as a mechanical cushion. However, prolonged loading may result in damage such as pressure ulcers. Depending on the severity and origin of the ulcer, skin, subcutaneous fat and muscle can be affected. The aetiology of pressure ulcers is still poorly understood; it is not even clear whether wounds start to develop in skin, in the fat layer or even in deeper layers [1]. One of the tools used to better understand the way mechanical loading affects tissues is mechanical modeling. The success of a mechanical model strongly depends on the constitutive equations that are used to describe the mechanical properties obtained with experimental work. For skin and muscle much is already known, but a tremendous lack of data is found regarding the properties of adipose tissue. In the case of the subcutaneous fat tissue, very few of the mechanical properties have been determined experimentally.
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Manorama, Abinand, and Tamara Reid Bush. "Skin Perfusion, Arterial and Venous Blood Flow, and Soft Tissue Thickness in Relation to Pressure Ulcers." In ASME 2013 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/sbc2013-14496.

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Pressure ulcers have been a concern in healthcare settings, with more than 50% of bedridden or wheelchair-bound patients being affected [1]. Pressure ulcers typically occur on a region of the body that experiences forces from an external structure (e.g. bed, wheelchair). Researchers believe that such forces cause a decrease in blood flow, which results in tissue necrosis, causing pressure ulcers [2].
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Rotariu, Mariana, Iustina Condurache, Catalin Ionite, and Marius Turnea. "ANALYSIS AND FORECASTING OF BURULI ULCER DISEASE WITH ARIMA AND NARNN, A DIDACTIC TOOL APPROACH." In eLSE 2021. ADL Romania, 2021. http://dx.doi.org/10.12753/2066-026x-21-178.

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Mycobacterium ulcers (MU) is pathogenic bacterium transmitted in aquatic environments that produces dermal ulcers, commonly known as "buruli ulcers" via complex networks of ecological interactions that can be modelled by compartments. The prevalence of aquatic insects and arsenic concentration are factors that determine the geographical spread of MU infection. Three approaches are taken into account: one based on a compartment model that led to a system of differential equation usually solved by numerical methods, an autoregressive integrated moving average model (ARIMA) and the third one based on neural networks, Autoregression Neural Network (NARNN). Other model as Long-Short Term Memory (LSTM) approach is taken also into account. A GUI (Graphic User Interface) is proposed to facilitate the access to students to models in a friendly manner. The mechanism of transmission and the compartments are not fully elucidated, so models that take into account the regression of the curve of incidence can be a useful tool to predict the epidemic evolution of buruli ulcer (BU). The dynamics of models can be controlled by saturated treatment function or other measures that limit the proliferation of vector of transmission like bugs. The experiments take into account real data published on official site and the most common measure of goodness of fit are included in tool: R2 and MSE (Mean Squared Error). Other error measures are enumerated but the relevance for proposed tool is relative reduced. The last two type of models proved to be enough accurate when the data are enough long as time series approach. Further developments of the tool are envisaged and other measures of fitness are taken into account along with optimization of parameters to fit the model based on ODEs.
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Ghani, M. U., C. Sanina, and A. Fojas. "Penetrating Aortic Ulcers- A Cardiovascular Emergency." In American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX. American Thoracic Society, 2019. http://dx.doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a3508.

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Reports on the topic "Ulcers"

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Barry, Charles, Mohamed Shefan Hameed, and Abilash Sathyanarayanan. Topical phenytoin use in diabetes related foot ulcers. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2023. http://dx.doi.org/10.37766/inplasy2024.1.0023.

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Heims, Jack. Re-evaluation Co-counseling and the Treatment of Peptic Ulcers. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.1753.

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Gowenlock, Linda S. Evaluating Evidence-Based Intervention to Prevent Fall and Pressure Ulcers. Fort Belvoir, VA: Defense Technical Information Center, December 2011. http://dx.doi.org/10.21236/ada618679.

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Onikzeh, Parinaz, Afshin Heidari, Aida Kazemi, Parisa Najjariasl, Kamran Dalvandi, Hamidreza Sadeghsalehi, and Hadi Zamanian. 3D photography versus digital planimetry in wound measurement : a systematic review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, October 2021. http://dx.doi.org/10.37766/inplasy2021.10.0069.

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Review question / Objective: The aim of this study is to find whether there is concordance between two methods of wound area measurement: 3D photography and digital planimetry. Condition being studied: One of the most important factors in all types of wound management is wound measurement and two new digital techniques are : digital planimetry and 3D-photography. Eligibility criteria: the articles will be included only if the study cases would be measured by both methods of wound measurement including 3D photography and digital planimetry. patients with wound in any area of their body like diabetic ulcers, venous ulcers or burning. not models or animals.not bite or scar or bruising. without any restriction in age or gender.
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Colleary, Colleen. An Investigation of Handedness and its Relationship to the Site of Contact Ulcers. Portland State University Library, January 2000. http://dx.doi.org/10.15760/etd.2049.

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Liu, Hong-wei. Effect of intraoperative pressure ulcer preventive nursing on inflammatory markers in patients with high-risk pressure ulcers: A protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, April 2020. http://dx.doi.org/10.37766/inplasy2020.4.0029.

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Fan, Weijing, Wenhui Li, Renyan Huang, Guobin Liu, Changgeng Fu, and Baozhong Yang. Hyperbaric Oxygen Therapy for treating chronic diabetic foot ulcers : an Overview of Systematic Reviews. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, January 2021. http://dx.doi.org/10.37766/inplasy2021.1.0008.

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Fan, Weijing, Xiao Yang, Feng Xv, Xiaoming Hu, Fang Guo, and Guobin Liu. Extracorporeal shockwave therapy for Diabetic foot ulcers Protocol for a systematic review and meta analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2020. http://dx.doi.org/10.37766/inplasy2020.11.0001.

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Sprigle, Stephen, and Sharon Sonenblum. Pressure Relief Behaviors and Weight-Shifting Activities to Prevent Pressure Ulcers in Persons with SCI. Fort Belvoir, VA: Defense Technical Information Center, October 2014. http://dx.doi.org/10.21236/ada616526.

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Xu, ke, Guofeng Cai, Yanan Cui, Ziyin Gao, and Manchao Sun. The Meta-analysis of efficacy and safety of acupuncture in the treatment of stage Ⅱ-Ⅳ pressure ulcers. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, April 2023. http://dx.doi.org/10.37766/inplasy2023.4.0033.

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Review question / Objective: The subjects were patients who met the diagnostic criteria for stage II - IV pressure ulcers.Interventional factors include various acupuncture treatments, including ordinary acupuncture, peripheral acupuncture, electroacupuncture or fire acupuncture. The course of treatment is more than 10 days.The control group was treated with conventional western medicine for more than 1 days.The main results included the time of complete healing, the time of granulation growth, and percentage of ulcer healed (PUHTP) in the trial period.The main results included the complete healing time, granulation growth time and percentage of ulcer healing (PUHTP), and the total effective rate and average healing time were calculated.The type of study was a randomized controlled trial.
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