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Journal articles on the topic "UHDRS"
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Silveira, Guilherme Wilson Souza, Dionatan Costa Rodrigues, Clarissana Araújo Botaro, and Luciana De Andrade Agostinho. "Avaliação funcional e motora da forma juvenil da doença de Huntington: relato de caso." Arquivos de Ciências da Saúde 27, no. 1 (December 11, 2020): 78. http://dx.doi.org/10.17696/2318-3691.27.1.2020.1725.
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Introdução: A doença de Huntington (DH) é uma desordem neurodegenerativa autossômica dominante e rara, com comprometimento motor, cognitivo e comportamental. O início dos sintomas precoces, com menos de 20 anos, caracteriza a forma infanto-juvenil da DH. O acompanhamento da evolução da doença é importante e permite determinar as limitações funcionais e motoras de acordo com a progressão de cada caso. Objetivo: Relatar um caso juvenil da doença de Huntington associando o genótipo e o fenótipo. Métodos: A escala Unified Huntington’s Disease Rating Scale (UHDRS), validada em português, foi aplicada por um profissional capacitado, utilizando as seções: Avaliação do Estado Funcional (FAS), Escala de Capacidade Funcional Total (TFC) e Escala de Independência (IS). Resultados: O indivíduo investigado é do sexo masculino com início dos sintomas motores aos 18 anos. Em 2019, o jovem tinha 12 anos de tempo dedoença e foi diagnosticado com DH, com alelos em heterozigose com 19 e 53 repetições CAG. As avaliações realizadas com a escala UHDRS associadas à avaliação funcional e motora, obtiveram os seguintes escores: UHDRS FAS = 18 pontos, UHDRS TFC =12, UHDRS IS = 90%e UHDRS TMS = 57 pontos. Conclusão: Pela variabilidade clínica associada à forma juvenil, o paciente deve ter tratamento personalizado, condizente com o comprometimento motor, funcional e comportamental apresentado. A UHDRS é escala mais indicada para avaliar indivíduos afetados pela DH, principalmente pelo alto grau de consistência e confiabilidade clínica.
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Tumas, Vitor, Sarah Teixeira Camargos, Paulo Samandar Jalali, Adriano de Paula Galesso, and Wilson Marques Jr. "Internal consistency of a Brazilian version of the unified Huntington's disease rating scale." Arquivos de Neuro-Psiquiatria 62, no. 4 (December 2004): 977–82. http://dx.doi.org/10.1590/s0004-282x2004000600009.
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We evaluated the reliability of a translated Brazilian version of the Unified Huntington's Disease Rating Scale (UHDRS) to establish the reproducibility of the scale in a population that differs substantially from that on which the scale was originally validated. After a training period with the video and guidelines requested from the Huntington Study Group, we applied the UHDRS, except for the cognitive tests, to a group of 21 Brazilian patients with a molecular diagnosis of Huntington's disease (HD). We found a high degree of internal consistency of the motor section of the UHDRS (Cronbach's alpha= 0.841). There was a negative correlation between the total motor score and the functional assessment, the independence scale and the functional capacity. There was a positive correlation between these 3 scales of functional evaluation and a negative correlation between the age of onset of the disease and the number of CAG repeats. The behavioral scale and disease duration were not correlated with any factor. The clinical characteristics of this sample of patients as described by the UHDRS were roughly similar to those reported in the original validation studies and the correlations described were similar to those reported previously. We conclude that the Brazilian version of the UHDRS is reliable and valid to study patients with HD in the Brazilian setting, that this sample of Brazilian patients had clinical characteristics similar to those observed in other world regions, as expected, and that the clinical training method used for the application of the UHDRS was effective to insure a high degree of clinical reproducibility.
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Winder, J. Y., W. P. Achterberg, S. L. Gardiner, and R. A. C. Roos. "Longitudinal assessment of the Unified Huntington's Disease Rating Scale (UHDRS) and UHDRS–For Advanced Patients (UHDRS‐FAP) in patients with late stage Huntington's disease." European Journal of Neurology 26, no. 5 (January 27, 2019): 780–85. http://dx.doi.org/10.1111/ene.13889.
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Winder, Jessica Y., Wilco P. Achterberg, Johan Marinus, Sarah L. Gardiner, and Raymund A. C. Roos. "Assessment Scales for Patients with Advanced Huntington's Disease: Comparison of the UHDRS and UHDRS-FAP." Movement Disorders Clinical Practice 5, no. 5 (August 24, 2018): 527–33. http://dx.doi.org/10.1002/mdc3.12646.
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van Marlen, Patricia, Max Dahele, Michael Folkerts, Eric Abel, Ben J. Slotman, and Wilko Verbakel. "Ultra-High Dose Rate Transmission Beam Proton Therapy for Conventionally Fractionated Head and Neck Cancer: Treatment Planning and Dose Rate Distributions." Cancers 13, no. 8 (April 13, 2021): 1859. http://dx.doi.org/10.3390/cancers13081859.
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Transmission beam (TB) proton therapy (PT) uses single, high energy beams with Bragg-peak behind the target, sharp penumbras and simplified planning/delivery. TB facilitates ultra-high dose-rates (UHDRs, e.g., ≥40 Gy/s), which is a requirement for the FLASH-effect. We investigated (1) plan quality for conventionally-fractionated head-and-neck cancer treatment using spot-scanning proton TBs, intensity-modulated PT (IMPT) and photon volumetric-modulated arc therapy (VMAT); (2) UHDR-metrics. VMAT, 3-field IMPT and 10-field TB-plans, delivering 70/54.25 Gy in 35 fractions to boost/elective volumes, were compared (n = 10 patients). To increase spot peak dose-rates (SPDRs), TB-plans were split into three subplans, with varying spot monitor units and different gantry currents. Average TB-plan organs-at-risk (OAR) sparing was comparable to IMPT: mean oral cavity/body dose were 4.1/2.5 Gy higher (9.3/2.0 Gy lower than VMAT); most other OAR mean doses differed by <2 Gy. Average percentage of dose delivered at UHDRs was 46%/12% for split/non-split TB-plans and mean dose-averaged dose-rate 46/21 Gy/s. Average total beam-on irradiation time was 1.9/3.8 s for split/non-split plans and overall time including scanning 8.9/7.6 s. Conventionally-fractionated proton TB-plans achieved comparable OAR-sparing to IMPT and better than VMAT, with total beam-on irradiation times <10s. If a FLASH-effect can be demonstrated at conventional dose/fraction, this would further improve plan quality and TB-protons would be a suitable delivery system.
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Du, Ran. "Impact of Caryolanemagnolol on Gait and Functional Mobility on Individuals with Huntington’s Disease." Tropical Journal of Pharmaceutical Research 14, no. 9 (November 9, 2015): 1713–17. http://dx.doi.org/10.4314/tjpr.v14i9.24.
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Purpose: To highlight the impact of caryolanemagnolol on gait measures in forward walking, balance and mobility measures, as well as in hand and forearm function measures.Methods: Twenty patients with Huntington’s disease (HD) on stable doses of caryolanemagnolol were evaluated after medication and again following resumption of medication. The improvement in spatiotemporal gait parameters was measured by GAITRite, balance and/or mobility using Tinetti mobility test (TMT), five times sit-to-stand test (5TSST), and six-condition Romberg tests, as well as the function of the hand and forearm by finger tapping and Luria tests on Huntington's disease rating scale (UHDRS) motor scale.Results: The results demonstrated significant improvement in the unified UHDRS motor scores, Tinetti mobility test (TMT) total and balance subscale scores, and the five times sit-to-stand test when oncaryolanemagnolol compared to off-caryolanemagnolol. Spatiotemporal gait measures, the six condition Romberg test, and UHDRS hand and forearm function items remained unaffected on caryolanemagnolol treatment. Improved TMT and 5TSST performance when on drug indicates that caryolanemagnolol use may improve balance and functional mobility in individuals with HD.Conclusions: Caryolanemagnolol improves chorea and functional mobility by improving dynamic balance in individuals without any negative impact on motor function in walking and transfers.Keywords: Huntington's disease, Caryolanemagnolol, Gait measures, Choreic movements, Mobility tests
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Costa Rodrigues, Dionatan, Gregory Youdan Jr., Carmen Lúcia Antão Paiva, and Luciana Andrade Agostinho. "Functional and motor evaluation in a Brazilian Huntington’s disease cohort." Revista Neurociências 30 (December 13, 2022): 1–32. http://dx.doi.org/10.34024/rnc.2022.v30.13713.
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Introduction. This study compared the results of motor performance obtained using three clinical scales for the assessment of Huntington’s disease (HD) progression, such as the Functional Independence Measure (FIM), Modified Barthel Index (MBI), and Unified Huntington's Disease Rating Scale (UHDRS), evaluating the motor performances of Brazilian HD participants and Reference Group (RG). Method. This was a cross-sectional, observational quantitative study. Sensitivity and specificity of the MBI and FIM scales were calculated using UHDRS as a reference scale. Results. The mean age at HD onset was 41.6±8.3 years, with a median value of disease time of 11 years. The mean age of the RG (n=22) was 51.5±7.6 years, and the HD group (n=22) 51.5±8.4 years. Females from the HD group were more severely affected in their functional and motor capacities as compared to the RG (p<.001). Conclusions. To the authors knowledge, this is the first study applying the FIM to participants with HD. Therefore, FIM and MBI can be applied to assess the HD functional performance, since when we compared the UHDRS functional sections we observed similar results (p<.01). The FIM and MBI scales are easy to administer and can be used to assess the functional performance of HD patients. Furthermore, they may be effective tools in rehabilitation programs, but further studies of these scales are warranted.
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Schobel, Scott A., Giuseppe Palermo, Peggy Auinger, Jeffrey D. Long, Shiyang Ma, Omar S. Khwaja, Dylan Trundell, et al. "Motor, cognitive, and functional declines contribute to a single progressive factor in early HD." Neurology 89, no. 24 (November 15, 2017): 2495–502. http://dx.doi.org/10.1212/wnl.0000000000004743.
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Objective:To identify an improved measure of clinical progression in early Huntington disease (HD) using data from prospective observational cohort studies and placebo group data from randomized double-blind clinical trials.Methods:We studied Unified Huntington Disease Rating Scale (UHDRS) and non-UHDRS clinical measures and brain measures of progressive atrophy in 1,668 individuals with early HD followed up prospectively for up to 30 to 36 months of longitudinal clinical follow-up.Results:The results demonstrated that a composite measure of motor, cognitive, and global functional decline best characterized clinical progression and was most strongly associated with brain measures of progressive corticostriatal atrophy.Conclusions:Use of a composite motor, cognitive, and global functional clinical outcome measure in HD provides an improved measure of clinical progression more related to measures of progressive brain atrophy and provides an opportunity for enhanced clinical trial efficiency relative to currently used individual motor, cognitive, and functional outcome measures.
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Tereshchenko, Alexander V., Jordan L. Schultz, Ansley J. Kunnath, Joel E. Bruss, Eric A. Epping, Vincent A. Magnotta, and Peg C. Nopoulos. "Subcortical T1-Rho MRI Abnormalities in Juvenile-Onset Huntington’s Disease." Brain Sciences 10, no. 8 (August 8, 2020): 533. http://dx.doi.org/10.3390/brainsci10080533.
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Huntington’s disease (HD) is a fatal neurodegenerative disease caused by the expansion of cytosine-adenine-guanine (CAG) repeats in the huntingtin gene. An increased CAG repeat length is associated with an earlier disease onset. About 5% of HD cases occur under the age of 21 years, which are classified as juvenile-onset Huntington’s disease (JOHD). Our study aims to measure subcortical metabolic abnormalities in JOHD participants. T1-Rho (T1ρ) MRI was used to compare brain regions of 13 JOHD participants and 39 controls. Region-of-interest analyses were used to assess differences in quantitative T1ρ relaxation times. We found that the mean relaxation times in the caudate (p < 0.001), putamen (p < 0.001), globus pallidus (p < 0.001), and thalamus (p < 0.001) were increased in JOHD participants compared to controls. Furthermore, increased T1ρ relaxation times in these areas were significantly associated with lower volumes amongst participants in the JOHD group. These findings suggest metabolic abnormalities in brain regions previously shown to degenerate in JOHD. We also analyzed the relationships between mean regional T1ρ relaxation times and Universal Huntington’s Disease Rating Scale (UHDRS) scores. UHDRS was used to evaluate participants’ motor function, cognitive function, behavior, and functional capacity. Mean T1ρ relaxation times in the caudate (p = 0.003), putamen (p = 0.005), globus pallidus (p = 0.009), and thalamus (p = 0.015) were directly proportional to the UHDRS score. This suggests that the T1ρ relaxation time may also predict HD-related motor deficits. Our findings suggest that subcortical metabolic abnormalities drive the unique hypokinetic symptoms in JOHD.
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Svetozarskiy, S. N., S. V. Kopishinskaya, and I. G. Smetankin. "Retinal and choroidal morphological changes in Huntington's disease." Russian Ophthalmological Journal 12, no. 1 (March 16, 2019): 56–63. http://dx.doi.org/10.21516/2072-0076-2019-12-1-56-63.
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Purpose: to investigate the choroidal and retinal morphology in Huntington's disease (HD) using optical coherence tomography (OCT) and to analyze how the parameters studied correlate with the clinical data. Material and methods. The study included two groups of subjects, (1) 44 HD patients, averagely aged 37.6 ± 10.2 yrs, and (2) 31 healthy volunteers, averagely aged 37.3 ± 10.8 yrs. The groups had matching age, sex distribution, intraocular pressure and mean refractive error. In the study group, 21 patients had pre-manifest and 23, manifest HD stage. All patients underwent a thorough neurological and ophthalmic examination which included retinal OCT. The foveal choroidal thickness, retinal thickness in 9 areas of the macular zone, retinal ganglion cells complex (GCC) and peripapillary retinal nerve fiber layer thickness (RNFL) were evaluated in 4 quadrants. CAG repeat expansion size (cytosine-adenine-guanine) in the huntingtin gene, the disease duration and Unified HD Rating Scale motor scores (UHDRS) were evaluated for HD patients. Results. The range of the CAG repeat expansion size in the study group was 37–56 repeats (44.3 ± 3.8), the UHDRS motor score was 36.3 ± 29.7, disease duration was 13.7 ± 7.2 years. OCT revealed a significant decrease in the foveal choroidal thickness, GCC complex thickness, average, temporal, inferior and nasal RNFL thickness and total retinal thickness in the external temporal area in HD patients as compared to the controls. In addition, an inverse correlation between the disease duration, UHDRS Motor Score and a number of OCT parameters was found. Conclusion. The results confirm the promising potential of retinal tomographic parameters as a biomarker for early diagnosis and monitoring of the neurodegenerative process progression. The topography of retinal thickness reduction indicates a specific pattern of retinal neurodegeneration in HD.
Dissertations / Theses on the topic "UHDRS"
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Lindström, Anna. "Huntingtons sjukdom och behandling av motoriska symtom : En jämförelse mellan tetrabenazin och pridopidin." Thesis, Umeå universitet, Farmakologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-118740.
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Introduktion: Huntingtons sjukdom är en ärftlig progressiv neurodegenerativsjukdom som orsakas av en mutation på kromosom 4. Mutationen sker genom enökning av cytosin-adenosin-guanin (CAG) sekvenser som kodar för aminosyranglutamin. Huntingtons sjukdom är komplex och dess symtom inträder vanligtvismellan 30 och 50 års ålder, de symtomen som uppkommer orsakas av de förändringarsom sker i hjärnan. Karaktäristiska symtom för Huntingtons sjukdom är en successivförsämring i både motorisk och kognitiv funktion samt olika psykiatriska symtom. Detär framförallt områden som de basala ganglierna och hypotalamus som drabbas, menäven hjärnbarken påverkas. I dagsläget finns ingen botande behandling ellerbehandling som kan påverka sjukdomsförloppet utan man behandlar de symtom somuppkommer. Symtomatisk behandling kan förbättra livskvalitén och underlättavardagen för de drabbade. Syfte: Syftet med litteraturstudien var att jämföra substanserna tetrabenazin ochpriodipidins effekt på motoriska symtom vid Huntingtons sjukdom med avseende påförändring i UHDRS-TMS. Metod: Litteratursökningar genomfördes i både PubMed och Cochranes databaser,med hjälp av MeSH termer och fritextsökningar. Till denna litteraturstudie valdes åttaorginalstudier ut, dessa analyserades och sammanställdes. En bedömningsmallanvändes för att värdera studiernas kvalité. Resultat: Pridopidin har för dosen 90 mg uppvisat en signifikant förändring iUHDRS-TMS i jämförelse med placebo, medan lägre doser av pridopidin inte var bättreän placebo. I den öppna fortsättningsstudien ökade däremot samtliga grupper iUHDRS-TMS. Tetrabenazin har inte uppvisat entydiga resultat, två studier visade på ensignifikant sänkning av UHDRS-TMS i jämförelse med placebo medan en studie visadepå en signifikant ökning av UHDRS-TMS. I den retrospektiva studien sågs en ökning avUHDRS-TMS både vid första och andra uppföljningen varav den sistnämnda varsignifikant. Diskussion: De studier som användes till detta arbete har haft olika studiedesign,studielängd och antal studiedeltagare samt haft varierande doser av de enskildasubstanserna. Vilket leder till olika förutsättningar och möjlighet till statistisk styrka idess resultat. Genomgående har studierna haft ett relativt lågt antal studiedeltagarevilket beror på sjukdomens låga prevalens. Mer forskning krävs inom det här området,dels för att hitta en bra symtomatisk behandling men också för att hitta ett sätt attförhindra och eller bota sjukdomen. Slutsats: Resultaten som påvisats är att både tetrabenazin och pridopidin tycks ha ensänkande effekt på motoriska symtom samt att de tenderar att tappa sin effekt vidlängre tids behandling. Tetrabenazin ger till störst del sin effekt genom att dämpa deofrivilliga rörelserna, chorean. På grund av studiens begränsningar kan inga konkretajämförelser dras mellan substanserna eftersom studierna som använts inte är heltjämförbara med varandra.
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Pereira, Cíntia Marques. "Challenges in flex binning ultra high resolution seismic reflection data." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/21923.
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Mestrado em Engenharia GeológicaOs dados sísmicos 3D podem conter “lacunas” de cobertura devido a diversos problemas operacionais. As “lacunas” em dados 3D podem causar impactos adversos em várias etapas do processamento de dados, tais como na análise de velocidade, atenuação dos múltiplos, “stack” e migração. O Flex Binning é um método expediente para resolver este problema. O método Flex Binning permite que cada bin contenha mais traços, aumentando o tamanho efectivo de cada bin e incluindo traços dos bins vizinhos. O desafio é aplicar o Flex Binning a um número muito grande de traços que excedem as soluções actuais de design de software e capacidade de hardware. Vários testes foram realizados no software Seismic Processing Workshop (SPW). Durante os vários testes realizados, foi possível detectar e resolver problemas de código e “bugs” de software tais como, por exemplo, a incapacidade de aplicar uma grelha ao conjunto de dados e deixar traços fora da grelha. A questão da indexação foi outro problema detectado, que se resolveu por uma mudança de design do software no fluxo de processamento CMP Binning. A realização de vários testes nas diversas versões do SPW permitiu avanços na implementação do Flex Binning para conjuntos de dados de elevadas dimensões, nomeadamente a execução do fluxo CMP Binning com sucesso num conjunto de dados com 751GB. No fluxo de processamento CMP Binning, antes destes testes só era possível aplicar o Flex Binning corretamente a um conjunto de dados com aproximadamente 30 GB de tamanho.
3D seismic reflection data may contain coverage gaps due to operational problems. The gaps in 3D data can cause adverse impacts in several steps of the data processing such as velocity analysis, multiple attenuation, stacking and migration. Flex Binning is an expedient method to solve these gaps. The Flex Binning method allows each bin to contain more traces, by increasing the effective size of each bin and thereby include traces which also fall into neighboring bins. The challenge is to apply Flex Binning to very large number of traces exceeding current software design solutions and hardware capability. Several tests were performed with the Seismic Processing Workshop (SPW) software. During several tests, coding problems and bugs were detected and corrected, such as the inability to apply a grid to the dataset and leave traces out of the grid. Also, proper indexing was also solved by a change of software design in CMP Binning code. Beta testing on SPW allowed advances in the implementation of Flex Binning to large inputs, namely the execution of the CMP Binning flow successfully to a dataset with 751GB. The CMP Binning step before the tests could only Flex Binning effectively to an input with a size of approximately 30 GB.
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Correia, Fábio Gonçalves. "Quality control of ultra high resolution seismic data acquisition in real-time." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/22007.
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Mestrado em Engenharia GeológicaA aquisicção de grandes volumes de dados durante uma campanha sísmica exige, necessariamente, mais tempo para o controlo de qualidade (QC). No entanto, o tempo de QC não pode ser extendido devido a limitações do tempo de operação, tendo de ser feito mais rápido, o que pode comprometer a qualidade. A alternativa, alocar mais pessoas e recursos para QC e melhorar a eficiência, leva a aumentos de custo e à necessidade de maiores embarcações. Além disso, o QC tradicional requer tempo de análise após a aquisição, atrasando a desmobilização da embarcação, aumentando assim os custos da aquisição. A solução proposta passou pelo desenvolvimento de um QC automático em tempo real eficiente, testando a Comparação Espetral e o Atributo Razão Sinal-Ruído - ferramentas desenvolvidas no software SPW, usado para processamento de dados sísmicos. Usando este software foi testada a deteção e identificação de dados de fraca qualidade através das ferramentas de QC automáticas e os seus parâmetros ajustados para incluir pelo menos todos os maus registos encontrados manualmente. Foi também feita a deteção e identificação de vários problemas encontrados durante uma campanha de aquisição, tais como fortes ondulações e respetiva direção, o ruído de esteira provocado pelas hélices da embarcação e consequente Trouser’s Effect e mau funcionamento das fontes ou dos recetores. A deteção antecipada destes problemas pode permitir a sua resolução atempada, não comprometendo a aquisição dos dados. Foram feitos vários relatórios para descrever problemas encontrados durante os testes de versões beta do software SPW e os mesmos reportados à equipa da Parallel Geoscience, que atualizou o software de forma a preencher os requisitos necessários ao bom funcionamento do QC em tempo real. Estas atualizações permitiram o correto mapeamento dos headers dos ficheiros, otimização da velocidade de análise das ferramentas automáticas e correção de erros em processamento dos dados em multi-thread, para evitar atrasos entre o QC em tempo real e a aquisição dos dados, adaptação das ferramentas à leitura de um número variável de assinaturas das fontes, otimização dos limites de memória gráfica e correção de valores anómalos de semelhança espetral. Algumas atualizações foram feitas através da simulação da aquisição de dados na empresa, de forma a efetuar alguns ajustes e posteriormente serem feitos testes numa campanha futura. A parametrização destas ferramentas foi alcançada, assegurando-se assim a correta deteção automática dos vários problemas encontrados durante a campanha de aquisição usada para os testes, o que levará à redução do tempo gasto na fase de QC a bordo e ao aumento da sua eficácia.
The acquisition of larger volumes of seismic data during a survey requires, necessarily, more time for quality control (QC). Despite this, QC cannot be extended due operational time constraints and must be done faster, compromising its efficiency and consequently the data quality. The alternative, to allocate more people and resources for QC to improve efficiency, leads to prohibitive higher costs and larger vessel requirements. Therefore, traditional QC methods for large data require extended standby times after data acquisition, before the vessel can be demobilized, increasing the cost of survey. The solution tested here consisted on the development of an efficient Real- Time QC by testing Spectral Comparison and Signal to Noise Ratio Attribute (tools developed for the SPW seismic processing software). The detection and identification of bad data by the automatic QC tools was made and the parameters adapted to include at least all manual QC flags. Also, the detection and identification of common problems during acquisition, such strong wave motion and its direction, strong propeller’s wash, trouser’s effect and malfunction in sources or receivers were carried out. The premature detection of these problems will allow to solve them soon enough to not compromise the data acquisition. Several problem reports from beta tests of SPW were transmitted to the Parallel Geoscience team, to be used as a reference to update the software and fulfil Real-Time QC requirements. These updates brought the correct mapping of data headers in files, optimization of data analysis speed along with multi-thread processing debug, to assure it will be running fast enough to avoid delays between acquisition and Real-Time QC, software design to read a variable number of source signatures, optimization of graphic memory limits and debugging of anomalous spectral semblance values. Some updates resulted from a data acquisition simulation that was set up in the office, to make some adjustments to be later tested on an upcoming survey. The parameterization of these tools was finally achieved, assuring the correct detection of all major issues found during the survey, what will eventually lead to the reduction of time needed for QC stage on board, as also to the improvement of its efficiency.
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Katata, Enoque Paulo. "Avaliação do impacto das condições de operação na qualidade do sinal : processamento de dados de reflexão sísmica de multicanal." Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/15655.
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Mestrado em Engenharia GeológicaAtravés do processamento de dados sísmicos convertem-se registos de campo em secções sísmicas com significado geológico, que revelam informações e ajudam a delinear as camadas geológicas do subsolo e identificar estruturas soterradas. Portanto, a interpretação dos dados sísmicos só é boa se o processamento também o for. Este trabalho é resultado de um estágio curricular na empresa de prospecção geofísica GeoSurveys, que consistiu principalmente em processar 18 linhas de dados de sísmica de reflexão multicanal de alta resolução adquiridas na ilha de Pulau Tekong em Singapura, que têm como finalidade investigação do solo da baia desta mesma ilha. Estes dados foram cedidos à GeoSurveys para fins académicos, caso em que se inclui esta dissertação. Para atingir os objectivos propostos que consistiam em avaliar o impacto das condições de operação na qualidade do sinal sísmico e interpretação das linhas, fez-se o processamento das linhas utilizando um fluxo processamento padrão utilizado na empresa, com recurso ao software Radex Pro. Este fluxo de processamento tem como mais-valia o método de correcções estáticas, o UHRS trim statics, além das técnicas habituais utilizadas para melhorar a resolução das secções sísmicas como é o caso da desconvolução, a atenuação de ruído através do stacking, correcções de NMO, e migração, entre outras técnicas. A interpretação das linhas sísmicas processadas foi feita no software Kingdom Suite (IHS), através da distinção da configuração interna dos reflectores em cada secção sísmica, estabelecendo deste modo as principais unidades sismo-estratigráficas e identificando as zonas de interface que delimitam os horizontes principais. Foi feito ainda um estudo geológico sumário da área de pesquisa e da evolução geodinâmica da região.
Through seismic data processing, multichannel seismic field records are converted into seismic sections with geological meaning, which help to delineate the subsurface geological layers and identify any buried structures. Therefore, seismic data interpretation is only good as the processing is. This work is the result of a curricular internship in a geophysical prospecting company, GeoSurveys. It consisted mainly of processing 18 high resolution seismic reflection multichannel lines obtained on the Island of Pulau Tekong, in Singapore, which were acquired to investigate the bottom and subsurface sediments of the Island bay. This work was kindly released to GeoSurveys for academic purposes, as it is the case of this dissertation. To achieve the objectives of this thesis, which are to assess the impact of operating conditions and processing on the quality of seismic signal and interpretation of the seismic lines, 18 seismic lines were processed with a standard processing flow used in the company, on the Radex Pro software. This processing flow has as the advantage of using the statics corrections method UHRS trim statics, besides the usual techniques used to improve the seismic resolution sections, such as deconvolution and noise attenuation by stacking, NMO corrections, and migration, among other techniques. The interpretation was made using the Kingdom software, through the analysis of the reflections internal configuration, and the identification of the main stratigraphic units. A summary geological study of the area of research area, together with its geodynamic evolution was also made and is presented in this thesis.
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Francisco, Andrade António. "Quality control of the positioning data in ultra high resolution reflection seismics." Master's thesis, 2020. http://hdl.handle.net/10773/30581.
Full textAbstract:
The quality control is a very important operation in the seismic data acquisition
surveys and its main goals are to assess the quality of the acquired data, to
detect problems during acquisition and finally to guarantee that the data has the
required quality to be accepted for further processing, or if it must be rejected.
The time spent in operations makes its cost to grow up and therefore the QC
must be done efficiently and as early as possible., It is critical that the most
relevant factors that can seriously compromise the data are evaluated onboard.
Navigation quality control is extremely important because the navigation errors
can contribute to the feathering effect that by itself is one of the main rejections
criteria. On the other hand, the quality of the positioning data can have strong
influence on the seismic resolution, as it is used to calculate positioning for every
reflection point. Thus, wrong positioning data affect offsets computing and can
move the reflection midpoints to erroneous position causing a discrepancy
between the actual geology and the seismic section obtained. This causes errors
in the exact location of boulders and the identification of other in-depth hazards
that threat the optimization of wind turbine installations, which is one of
Geosurveys goals in this type of surveys.
The main sources of these problems are related to the bad functioning of GPS
antennas used in the acquisition system and other systematic problems such as
geometry assignment. There are typical errors which affect the geometry such
as distance measurement between lead buoy center and first channel, distance
measurements and assignment between channels in the different streamer
sections. The solution proposed in this work consists on the development of
effective methods to diagnose these types of problems, where through a
graphical scheme it becomes possible to detect different types of positioning
errors and their causes.
The method developed in the scope of this work was based on the quality control
of the offsets calculated with the positioning data and the direct arrivals time.
With this information it was possible to establish a classification criterion for the
positioning data according to its quality, to calculate the errors and obtain
indicators about its source of error, always considering that the various factors
have different influences on the errors and some problems appear more
frequently than others. Based on this, rejection criteria for data with positioning
errors was established and solutions were tested in the software packages
RadExPro and Kingdom Suite, in order to evaluate the effect of these errors on
the seismic volumes.O controle de qualidade é uma operação muito importante durante as campanhas de aquisição de dados sísmicos. Tem como objetivo avaliar a qualidade dos dados adquiridos, detetar problemas ocorridos durante a aquisição, e finalmente assegurar que os dados têm a qualidade necessária para serem aceites ou se devem ser rejeitados. O tempo de operação tem consequências diretas sobre os custos e, por esta razão, esta é uma operação que deve ser feita rapidamente. Assim, devem ser avaliados os fatores mais relevantes que podem comprometer seriamente a qualidade dos dados. O controle de qualidade da navegação é de extrema importância, visto que os erros de navegação contribuem para o feathering, que por sua vez constitui um dos principais critérios de rejeição. Por outro lado, a qualidade da navegação ou dos dados de posicionamento pode afetar fortemente a resolução sísmica pelo facto de serem usados para a determinação das posições das reflexões. Assim, dados de posicionamentos errados afetam os cálculos dos offsets e podem deslocar os pontos médios de reflexões para posições erradas, provocando uma discrepância entre a geologia real e a secção sísmica obtida. Deste modo, fica mais difícil a localização exata de blocos rochosos e a identificação de outros perigos em profundidade que colocam em risco a otimização das instalações das turbinas eólicas, trabalhos que a Geosurveys tem vindo a realizar. As principais causas na origem destes problemas estão relacionadas com o mau funcionamento das antenas GPS usadas no sistema de aquisição, e outros problemas sistemáticos, como a atribuição de geometria. Existem erros típicos que afetam a geometria, tais como o erro na medição da distância entre o centro da antena da lead buoy e o primeiro canal, e erros na medição e atribuição das distâncias entre canais para as diferentes secções dos streamers. A solução proposta neste trabalho passou pelo desenvolvimento de métodos eficientes para diagnóstico destes tipos de problemas, onde através de padrões gráficos se torna possível detetar diferentes tipos de erros de posicionamentos e as respetivas causas. O método desenvolvido baseou-se no controle de qualidade dos offsets calculados com os dados de posicionamento e no tempo de chegada das ondas diretas. Com essas duas informações foi possível estabelecer um critério de classificação dos dados de posicionamento quanto à sua qualidade, calcular os erros e obter indícios sobre a sua origem, levando sempre em consideração que os vários fatores têm diferentes influências sobre os erros e que alguns problemas são mais frequentes que outros. Com base neste procedimento, foram estabelecidos critérios de rejeição de dados com erros de posicionamento. As soluções obtidas foram testadas no software RadExPro e Kingdom Suite de modo a avaliar o efeito que esses erros têm sobre a sísmica.
Mestrado em Engenharia Geológica
Books on the topic "UHDRS"
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Gegenwart der Einheit: Zum Begriff der Religion : Festschrift anlässliich des 60. Geburtstages Bernhard Uhdes. Freiburg i. Br: Rombach, 2008.
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Hoke, Sarah. Fritz von Uhdes "Kinderstube": Die Darstellung des Kindes in seinem Spiel- und Wohnmilieu. Universitätsverlag Göttingen, 2011.
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V, Carnahan James, and Segan E. G, eds. Effects of leak detection/location on underground heat distribution systems (UHDS) life cycle costs: A probabilistic model. [Champaign, Ill.]: Construction Engineering Research Laboratory, 1991.
Find full textBook chapters on the topic "UHDRS"
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"„Ich war nie zufällig befreundet“ – Wilhelm Uhdes Vermarktungsstrategien und seine Korrespondenz mit Georg Swarzenski." In Vergessene Körper: Helmut Kolle und Max Beckmann, 81–85. transcript-Verlag, 2015. http://dx.doi.org/10.14361/9783839432815-008.
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Wilhelm, Miriam. "„Ich war nie zufällig befreundet“ – Wilhelm Uhdes Vermarktungsstrategien und seine Korrespondenz mit Georg Swarzenski." In Vergessene Körper: Helmut Kolle und Max Beckmann, 81–85. transcript Verlag, 2015. http://dx.doi.org/10.1515/9783839432815-008.
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"„Mein Gott, wie die Zeit vergeht – h ier kennt man kaum Herrn Uhde“ – D ie Rolle Wilhelm Uhdes in der Pariser Kunstszene." In Vergessene Körper: Helmut Kolle und Max Beckmann, 86–91. transcript-Verlag, 2015. http://dx.doi.org/10.14361/9783839432815-009.
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Etter, Annika. "„Mein Gott, wie die Zeit vergeht – h ier kennt man kaum Herrn Uhde“ – D ie Rolle Wilhelm Uhdes in der Pariser Kunstszene." In Vergessene Körper: Helmut Kolle und Max Beckmann, 86–91. transcript Verlag, 2015. http://dx.doi.org/10.1515/9783839432815-009.
Full textConference papers on the topic "UHDRS"
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Winder, Jessica Y., Wilco P. Achterberg, Johan Marinus, Sarah L. Gardiner, and Raymund AC Roos. "F58 Assessment scales for patients with advanced huntington’s disease: comparison of the UHDRS and UHDRS-FAP." In EHDN 2018 Plenary Meeting, Vienna, Austria, Programme and Abstracts. BMJ Publishing Group Ltd, 2018. http://dx.doi.org/10.1136/jnnp-2018-ehdn.159.
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Souza, Thierry Kaue Alves Silva, Nara Maria Borges Alves, Fabiana Moraes, Felipe de Paula, Luciana Yasuda Suemitsu, Paula Azevedo, Luiza Piovesana, et al. "Cortical and subcortical atrophy in individuals with Huntington's disease and Huntington-like disease." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.551.
Full textAbstract:
Background: Huntington-like (HL) syndrome represents a group of diseases clinically similar to Huntington disease (HD) with different genetic etiology. Here, we aimed to compare clinical and neuroimaging features between HL and HD. Methods: We assessed 12 patients with HL (6 men; 53.66±13.02 years old) and 12 with HD (genetically confirmed, 6 men; 52.58±11.64 years old). All patients were followed at UNICAMP and were matched to sex, age, age at onset and duration of disease. They underwent 3T MRI scans, detailed neurological examination, the unified Huntington’s disease rating scale (UHDRS), the Montreal cognitive assessment (MOCA), Beck depression inventory (BDI), and the scale for the evaluation of rating ataxia (SARA). We APPLIED voxel-based morphometry technique (SPM12/CAT12/MATLAB software) to assess differences in the gray and white matters between groups and matched controls. Results: Groups were clinically similar, but the VBM study revealed widespread cortical (bilateral) and subcortical atrophy in HD (bilateral globi pallidi, amygdala, hippocampi, caudate and putamen), with a more restricted cortical (left temporal lobe) subcortical atrophy in HL (bilateral thalami, putamen and left hippocampus). Cortical atrophy in HL concentrated in the bilateral putamen. The left hippocampus were atrophic in both groups. Conclusion: Despite similar clinical presentation, patients with HL and HD have distinctive patterns of atrophy subcortical structures, mainly in the thalami. These results may raise insights into the underlying disease mechanisms in HL and HD and could be useful as biomarkers of disease progression in future therapy trials.
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Brito, Arthur Gomes Da Silva, Andressa Garcia Tavares Cruz, Gabriela Ribeiro Marques, Thamiris Pereira de Souza, and Leticia Goulart Japiassu. "ANÁLISE DA MUTAÇÃO E FISIOPATOLOGIAS DA DOENÇA DE HUNTINGTON: REVISÃO DE LITERATURA." In I Congresso On-line Nacional de Histologia e Embriologia Humana. Revista Multidisciplinar em Saúde, 2022. http://dx.doi.org/10.51161/rems/3208.
Full textAbstract:
Introdução: A doença de Huntington (DH), considerada uma patologia neurodegenerativa, autossômica dominante, é a doença poliglutamínica mais comum, com prevalência de 3 a10 indivíduos para cada 100.000 indivíduos. Descrita pela primeira vez no século 19, apresenta uma transmissão familiar, com alteração génica no tripleto CAG. A DH é uma mutação que permite a expansão de resíduos de glutamina no terminal amínico. Dessa forma, características neuropatológicas e clinicas da doença, são de declínio cognitivo e perturbações psiquiátricas, podendo se assemelhar a alteração de movimentos, irritabilidade e depressão. Objetivo: Descrever as fisiopatologias e patologias clinicas que pacientes com DH enfrentam, e caracterizar como isso influência nas suas capacidades físicas e sociais. Metodologia: Realizou-se uma pesquisa bibliográfica utilizando artigos originais nas bases de dados Biblioteca Virtual em Saúde e Scielo. Os descritores foram Doença de Huntington, Qualidade de Vida e Neurofisiologia. Os critérios de inclusão foram artigos nos idiomas inglês e português, publicados nos últimos cinco anos. Descartou-se estudos duplicados, não gratuitos e que não atendiam ao tema. Resultados: A DH caracteriza-se por se apresentar como uma doença que apresenta declínio cognitivo progressivo e perturbações psiquiátricas. Esse pode ser dividido em fases, sendo a fase inicial a mais sutil, com alterações moderadas nos movimentos e na capacidade cognitiva e a última fase a mais grave com movimentos involuntários constantes e perda da comunicação. Considerado uma doença de transmissão hereditária, apresenta uma repetição, na forma embrionária, do tripleto CAG, uma patologia autossômica dominante, que apresenta instabilidade durante a meiose. Classificado de acordo com a escala de UHDRS, a morte dos pacientes dá-se principalmente de complicações respiratórias. Assim, a gradual perda da capacidade motora e cognitiva afeta a sobrevida dos pacientes, assim como, sua qualidade de vida. Conclusões: Dessa forma, o estudo aprofundado do gene mutante responsável pelo DH foi bastante difundido entre a comunidade cientifica, assim como, as alterações clínicas. No entanto, não foi encontrado tratamentos satisfatórios que prezem pela qualidade de vida dos pacientes, a falta de uma terapêutica eficaz faz com que a perspectiva de melhora seja.
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Duarte, H. "Industrial 2D and 3D Ultra High Resolution Seismic (UHRS) Marine Surveying." In 3rd Applied Shallow Marine Geophysics Conference. Netherlands: EAGE Publications BV, 2018. http://dx.doi.org/10.3997/2214-4609.201802676.
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Games, K. P., and N. D. Wakefield. "The Successful Design, Development and Acquisition of a UHRS 3D Seismic Dataset." In Near Surface Geoscience 2014 - First Applied Shallow Marine Geophysics Conference. Netherlands: EAGE Publications BV, 2014. http://dx.doi.org/10.3997/2214-4609.20142132.
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Cox, P., E. K. Mauritzen, A. Fogg, P. Salek, R. Ward, and G. Hulks. "Broadband Processing Across The Uhrs Bandwidth – A Case Study From a Baltic Sea Offshore Windfarm." In NSG2022 28th European Meeting of Environmental and Engineering Geophysics. European Association of Geoscientists & Engineers, 2022. http://dx.doi.org/10.3997/2214-4609.202220152.
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Thaker, T. P., K. S. Rao, Ganesh W. Rathod, and K. K. Gupta. "DEVELOPMENT OF UHRS AND SWV MODELS FOR SURAT CITY AND SURROUNDING REGION OF GUJARAT, INDIA." In Proceedings of the 3rd and 5th International Conference. WORLD SCIENTIFIC, 2011. http://dx.doi.org/10.1142/9789814365161_0059.
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Johnson, James J., Oliver Schneider, Werner Schuetz, Philippe Monette, and Alejandro P. Asfura. "Effects of SSI on EPR™ In-Structure Response for a Rock Site: Coherent and Incoherent High Frequency Ground Motion." In ASME 2010 Pressure Vessels and Piping Division/K-PVP Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/pvp2010-26072.
Full textAbstract:
Recently, probabilistic seismic hazard assessments (PSHAs) performed for hard sites world-wide have yielded uniform hazard response spectra (UHRS) with significant high frequency content, i.e., frequency content greater than 10 Hz. This high frequency content is frequently due to near-field relatively low magnitude events. It is well known that these high frequency ground motions are not damaging to ductile structures, systems, and components (SSCs). One method of addressing the effect of these high frequency ground motions on structure response is to take into account the incoherency of ground motion. Over the past 25 years, free-field ground motion has been recorded providing an adequate basis for the development of ground motion coherency functions necessary to assess the effect of incoherence on nuclear power plant structures. The subject of this study was the AREVA NP EPR™ (European Power Reactor) nuclear island (NI) standard design. The effect of incoherency of ground motion on in-structure response spectra (ISRS) was assessed for the NI founded on a stiff rock site and subjected to high frequency enhanced input for hard rock sites. The ISRS at numerous locations and directions in the structures were calculated and compared. SSI is shown to be an important phenomenon for structures founded on stiff sites and subjected to high frequency ground motions.