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1
Dorsey, Mark. "The U.F.O. and the broadening-out controversy: crisis of farmer identity in a changing world." SURG Journal 2, no. 1 (October 5, 2008): 39–46. http://dx.doi.org/10.21083/surg.v2i1.797.
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This essay explores the subject of farmer identity in Ontario during the United Farmers of Ontario (UFO) administration, 1919-1923. Although a wealth of scholarly attention has been given to the UFO, the focus has conventionally only been on the politics of the group. This particular paper seeks to address a gap in the historiography of the UFO by trying to determine the extent to which farmer identity was experiencing change during the UFO’s administration. Using a variety of primary source materials, this paper takes an in-depth look at how farmers saw themselves and how they were viewed by others. With a particular emphasis on how two polar-opposite personalities, E.C. Drury and J.J. Morrison, represented the conflicting opinions of the farming sector as a whole, this essay comes to the conclusion that the UFO’s “broadening out controversy” coincided with a major re-evaluation of farmer identity, the last time that such extensive discussion about the personality of agriculture took place in Canada.
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CUESTA-PORTA, VICTOR, GEORGE MELIKA, JAMES A. NICHOLLS, GRAHAM N. STONE, ARMANDO EQUIHUA-MARTINEZ, EDITH ESTRADA-VENEGAS, and JULI PUJADE-VILLAR. "Revision of the Amphibolips ‘niger’ group with the description of a new species (Hymenoptera: Cynipini)." Zootaxa 5360, no. 4 (October 30, 2023): 451–86. http://dx.doi.org/10.11646/zootaxa.5360.4.1.
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Amphibolips is currently divided into two species-groups, clearly differentiated by adult and gall morphology. The ‘niger’ group of Amphibolips species is revised. This complex includes eight species: A. gumia Kinsey, A. jubatus Kinsey, A. elatus Kinsey, A. maturus Kinsey, A. nebris Kinsey, A. niger Kinsey, A. pistrix Kinsey and A. ufo Cuesta-Porta & Pujade-Villar sp. nov. We provide descriptions of new species and re-descriptions of known species, diagnoses, keys to complexes and species. The possibility of the ‘niger’ complex belonging to a new genus is also discussed.
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Ніфатова, Олена Михайлівна. "ІНСТИТУЦІЙНЕ ЗАБЕЗПЕЧЕННЯ КОМПЛЕКСНОЇ СИСТЕМНОЇ ПІДТРИМКИ СОЦІАЛЬНОЇ АДАПТАЦІЇ ТА РЕІНТЕГРАЦІЇ УЧАСНИКІВ ООС (АТО) І ВПО." Bulletin of the Kyiv National University of Technologies and Design. Series: Economic sciences 127, no. 5 (March 29, 2019): 54–61. http://dx.doi.org/10.30857/2413-0117.2018.5.5.
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The paper discusses the issues of institutional integrated systematic support for ensuring social adaptation and reintegration of United Forces Operation (UFO) (formerly ATO) participants and internally displaced persons (IDPs). Insights are provided on the "Program of support, social adaptation and reintegration of Ukrainian citizens who moved from the temporarily occupied territory of Ukraine and areas of the anti-terrorist operation to other regions of Ukraine" along with the laws and Government regulations on the maintenance of social adaptation of the above population group in terms of efficient utilization of their labor potential. The study of different dimensions in promoting integration and social adaptation of the IDPs and UFO (ATO) participants allowed to identify the following subsequent stages in the process of integration of displaced persons into the local community: the preliminary phase affected by the integration factors; initial (adaption period); modification (transformation) stage related to the integration implementation; and the resultant one reinforcing the integration indicators. It has been revealed that large-scale integration involves: adjustment of a range of social and economic indicators; ensuring equal treatment to migrants within local community; providing conflict-free interaction; effective cooperation and partnership; long-lasting multi-level relationships; satisfaction with social status, comfort; positive perception of the environment in harmony with self-perception; positive demographic dynamics; linking the future of the community with the national labor potential enhancement. The research findings on the specifics of providing the institutional integrated systematic support for social adaptation and reintegration of UFO (ATO) participants and IDPs have enabled to build up and generalize the dimensions for promoting integration and social adaptation of the given population group concerned.
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Imbusch, Peter, and Joris Steg. "Die Komplexität von Tarifauseinandersetzungen – eine Konflikttypologie auf Basis der Tarifkonflikte bei der Lufthansa." Industrielle Beziehungen. Zeitschrift für Arbeit, Organisation und Management 28, no. 1-2021 (September 2, 2021): 53–75. http://dx.doi.org/10.3224/indbez.v28i1.03.
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Der Artikel untersucht die Tarifkonflikte bei der Lufthansa Group, die in den Jahren 2000–2019 zwischen dem Unternehmen und den Gewerkschaften VC (Cockpit), UFO (Kabine) und ver.di (Boden) stattfanden. Auf der Grundlage eines konflikttheoretischen Rahmens werden zunächst die beteiligten Akteure und ihre Interessen vorgestellt, bevor die vielgestaltige Konfliktgeschichte zwischen der Lufthansa und ihren Gewerkschaften selbst dargelegt wird. Anschließend systematisieren wir die unterschiedlichen Konflikte nach ihren Ursachen und Hintergründen, um sie – geordnet nach Eskalationsstufen – in eine Konflikttypologie zu überführen. Dabei hat sich gezeigt, dass sich hinter vermeintlichen Tarifauseinandersetzungen häufig tiefergehende Konflikte mit hohem Eskalationspotenzial verbergen. Der Beitrag zeigt die grundsätzliche Unabschließbarkeit und fortdauernde Aktualität sozialer Konflikte zwischen Unternehmen und Gewerkschaften auf und betont die Relevanz eines konstruktiven Konfliktmanagements.
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Bokovikov, Ivan Fedorovich, Konstantin Viktorovich Protasov, and Natalia Anatolievna Khramtsova. "LEUKOCYTE INDICATORS OF INFLAMMATORY IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND TYPE 2 DIABETES MELLITUS." Baikal Medical Journal 2, no. 3 (September 10, 2023): 34–36. http://dx.doi.org/10.57256/2949-0715-2023-3-34-36.
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Introduction. Acute myocardial infarction is accompanied by an intense inflammatory response. On the other hand, the severity of inflammation is a marker of the risk of poor prognosis. Type 2 diabetes mellitus (DM2) is associated with the development of chronic inflammation and oxidative stress. Objective: To conduct a comparative analysis of leukocyte indicators of inflammation and highly sensitive C-reactive protein (hsCRP) in patients with ST-segment elevation acute myocardial infarction (STEMI) with and without DM 2. Materials and methods. Inclusion criteria: men and women with STEMI with or without type 2 diabetes, age over 45 years, primary percutaneous coronary intervention (PCI). Exclusion criteria: cases of hospital mortality, acute heart failure according to Killip 3-4 at admission. The study included 30 patients with STEMI in combination with type 2 diabetes and 30 patients with STEMI without type 2 diabetes. The groups were matched by sex (15 men and 15 women in each group) and age (64.2 vs 63.8 years, p= 0.8049). In both groups, we compared leukocyte indicators of inflammation (the number of leukocytes, neutrophils, lymphocytes, neutrophil-lymphocyte ratio (NLO) and hsCRP before pcCI, as well as their dynamics on days 5–7 after pcCI. The study of the cellular composition of blood was performed on a hematological analyzer BC- 6800Plus, Mindray, China.HsCRP was determined by the method of biochemical analysis of blood on the analyzer BS-200, Mindray, China.Data are presented as mean (M) and standard deviation (SD).The distribution of variables was normal, therefore, to compare quantitative indicators in independent and in paired samples, Student's t-test was used, and Pearson's chi-square, 2 test was used to compare lesion locations in study groups. Results. Body mass index was higher in the STEMI group with type 2 diabetes (30.2 kg/m2 and 26.6 kg/m2, p = 0.001). Groups of patients with and without type 2 diabetes did not differ in the incidence of anterior STEMI (43.3% and 56.6%; p2 =0.302), left ventricular ejection fraction 46.4% and 47.3%, p=0.399) . In the study groups with STEMI and DM 2 and without DM 2, such indicators as leukocytes (14.66±2.07×109/l vs 10.19±1.08×109/l, p<0.001) and (13, 92±1.73×109/L vs 9.81±1.77×109/L, p<0.001), neutrophils (8.64±1.2×109/L vs 5.36±0.97×109 /l, p<0.001) and (7.99±0.76×109/l vs 5.01±0.75×109/l, p<0.001), UFO (5.34±1.34 vs 2, 92±0.81, p<0.001) and (4.71±0.89 vs 2.75±0.96, p<0.001) and hsCRP (27.97±6.87 mg/l vs 13.23± 3.57 mg/l, p<0.001) and (29.86±5.91 mg/l vs 11.63±3.48 mg/l, p<0.001) decreased statistically significantly on days 5–7 of treatment in both groups, respectively. Lymphocytes (1.68±0.33×109/L vs 1.92±0.42×109/L, p<0.001) and (1.74±0.29×109/L vs 1.95±0, 45×109/l, p<0.001) in dynamics significantly increased in both groups, respectively. An intergroup comparative analysis showed that the degree of change in UFO at admission (5.34±1.34 vs 4.71±0.89, p=0.038) was statistically greater in the group with STEMI and DM 2. HsCRP decreased over time to a greater extent in the group with STEMI without DM 2 (-14.74±5.33 mg/l vs -18.23±5.25 mg/l, p=0.013). Upon admission, neutrophils (8.64±1.20×109/L vs 7.99±0.76×109/L, p=0.015) and UFOs (5.34±1.34 vs 4.71±0.89 , p=0.038) was statistically higher in the STEMI group with DM 2 than in the STEMI group without DM 2, respectively. Conclusions: In both groups, all studied leukocyte indicators of inflammation, with the exception of monocytes, decreased by 5-7 days from the moment of admission. In patients with STEMI and type 2 DM, there was a significant increase in the level of neutrophils and UFO at admission and a slower dynamics of the decrease in hsCRP, compared with the group of patients with STEMI and without type 2 DM, which indicates a more pronounced inflammatory response associated with acute infarction in type 2 DM myocardium.
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Lufthansa, Luthfie. "Pengembangan model pembelajaran atletik nomor lempar untuk anak tunagrahita ringan." Jurnal Keolahragaan 5, no. 1 (April 16, 2017): 39. http://dx.doi.org/10.21831/jk.v5i1.12803.
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Penelitian ini bertujuan menghasilkan model pembelajaran atletik nomor lempar untuk anak tunagrahita ringan. Penelitian pengembangan ini dilakukan dengan langkah-langkah sebagai berikut: (1) pengumpulan informasi di lapangan, (2) analisis terhadap informasi, (3) pengembangan produk awal, (4) validasi ahli dan revisi, (5) uji coba lapangan kelompok kecil dan revisi, (6) uji coba lapangan kelompok besar dan revisi, dan (7) pembuatan produk final. Instrumen pengumpulan data yang digunakan yaitu: (1) pedoman wawancara, (2) skala nilai, dan (3) pedoman observasi. Teknik analisis data yang dilakukan yaitu teknik analisis deskriptif kuantitatif dan analisis deskriptif kualitatif. Penelitian menghasilkan buku panduan pembelajaran atletik nomor lempar untuk anak tunagrahita ringan yang berisikan delapan model, yaitu (1) model pembelajaran netting menolak, (2) model pembelajaran menolak peluru, (3) model pembelajaran mengayun gelang warna melewati net, (4) model pembelajaran mengayun piring ufo ke bulan, (5) model pembelajaran melempar bola berekor dengan sasaran dengan sasaran simpai yang digantung, (6) model pembelajaran melempar roket ke bintang, (7) model pembelajaran bermain netting melontar, dan (8) model pembelajaran melontar komet ke matahari.Kata Kunci: anak tunagrahita ringan, pembelajaran atletik, nomor lempar, pengembangan Developing a Learning Model of Throwing Games in Athletics for Slightly Mentally-Retarded Children AbstractThis study aims to develop a learning model of throwing games in athletics for slightly mentally retarded children. The research and development study was conducted in the research and development steps as follows: (1) collecting information in the field, (2) analyzing the information, (3) developing the preliminary product, (4) conducting expert validation and revision, (5) conducting a small-group field tryout and revision, (6) conducting a large-group field tryout and revision, and (7) making the final product. The data collection instruments included: (1) an interview guideline, (2) a grade scale, and (3) an observation guideline. The data were analyzed by means of quantitative and qualitative descriptive techniques. The study produces a guidebook for the learning of throwing games in athletics for slightly mentally retarded children consisting of eight models, i.e.: (1) a learning model of the push netting, (2) a learning model of the shot put, (3) a learning model of swinging color rings over a net, (4) a learning model of swinging an UFO plate to the moon, (5) a learning model of throwing a tailed ball at a hanging hoop target, (6) a learning model of throwing a rocket to a star, (7) a learning of the throwing netting game, and (8) a learning model of throwing a comet to the sun.Keywords: slightly mentally retarded children, athletics learning, development
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Bozsó, Miklós, Chang-Ti Tang, Zsolt Pénzes, Man-Miao Yang, Péter Bihari, Juli Pujade-Villar, Szabina Schwéger, and George Melika. "A new genus of cynipid inquiline, Lithosaphonecrus Tang, Melika & Bozsó (Hymenoptera: Cynipidae: Synergini), with description of four new species from Taiwan and China." Insect Systematics & Evolution 46, no. 1 (January 24, 2015): 79–114. http://dx.doi.org/10.1163/1876312x-45032116.
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The cynipid inquilines genus Saphonecrus is known to be a polyphyletic group with distinct lineages. One lineage is associated with Synophrus in the Western Palaearctic on section Cerris oaks. Another involves the type species of Saphonecrus, S. connatus, and represents a distinct and probably early-diverging lineage with a Palaearctic distribution on white oaks. The third main lineage is predominantly Asian, and associated with Quercus subgenus Cyclobalanopsis and Quercus section Cerris and the oak-related Fagaceae including Lithocarpus. This third lineage shows large diversity, and includes the genus Ufo, the European lineage of S. undulatus and S. haimi, and the herein described new genus, Lithosaphonecrus Tang, Melika & Bozsó, known from Taiwan and China, with four new species: L. formosanus Melika & Tang, L. dakengi Tang & Pujade-Villar, L. huisuni Tang, Bozsó & Melika and L. yunnani Tang, Bozsó & Melika. All the four described species are associated only with Lithocarpus. Descriptions, diagnoses, biology, and host associations for the new genus and species are given, as well as a key to species and cynipid inquilines genera. All taxa are supported by morphological and molecular data.
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Stubbings, Daniel, Sophie Ali, and Alexander Wong. "Who Sees UFOs? The Relationship Between Unidentified Anomalous Phenomena Sightings and Personality Factors." Journal of Scientific Exploration 38, no. 1 (April 9, 2024): 11–27. http://dx.doi.org/10.31275/20243153.
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Unidentified Anomalous Phenomena (UAP) have become a serious topic in the US Congress, and new legislation has been released outlining a plan for declassification for the public. There are numerous factors that could lead an individual to mistakenly think they saw a UAP, and one of those factors might be the proclivities of the personalities that observe what they think to be a UAP. This study examined the big five personality traits: extraversion, neuroticism, openness, agreeableness, and conscientiousness, as well as schizotypy traits, to see if UAP experiencers could be distinguished from people who had not seen a UAP. The study included 206 participants, with 103 people who self-reported to have seen a UAP. Latent profile analysis was conducted on the personality variables to explore the grouping of participants. Group one was average on the traits, a second cluster was labeled as the Neurotic/Schizotypy group, which was high in neuroticism and schizotypy traits, and a third group was labeled as O-ACE, which were high on openness, agreeableness, conscientiousness, and extraversion but low on neuroticism and schizotypy traits. The findings indicated that the O-ACE group was more likely to see UAP, but this effect was not strong. A presumptuous stereotype exists in the general public that people who see UAP are probably people who are emotionally reactive (neurotic) and vulnerable to perceptual and cognitive abnormalities, but this was not evident in our data. We also found that the descriptive UAP accounts by the general public were similar to the descriptions provided by military witnesses. It was also of note that only 28% of participants reported their sightings anywhere, and 14% used a UFO reporting organization, which suggests that events are vastly underreported. Stigma and a lack of places to legitimately report sightings appeared to be primary barriers. The conclusion of this study is that personality factors are an insufficient explanation for most UAP sightings.
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Lin, Sen, Ruihang Zhang, Zemeng Ning, and Jie Luo. "TCRN: A Two-Step Underwater Image Enhancement Network Based on Triple-Color Space Feature Reconstruction." Journal of Marine Science and Engineering 11, no. 6 (June 13, 2023): 1221. http://dx.doi.org/10.3390/jmse11061221.
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The underwater images acquired by marine detectors inevitably suffer from quality degradation due to color distortion and the haze effect. Traditional methods are ineffective in removing haze, resulting in the residual haze being intensified during color correction and contrast enhancement operations. Recently, deep-learning-based approaches have achieved greatly improved performance. However, most existing networks focus on the characteristics of the RGB color space, while ignoring factors such as saturation and hue, which are more important to the human visual system. Considering the above research, we propose a two-step triple-color space feature fusion and reconstruction network (TCRN) for underwater image enhancement. Briefly, in the first step, we extract LAB, HSV, and RGB feature maps of the image via a parallel U-net-like network and introduce a dense pixel attention module (DPM) to filter the haze noise of the feature maps. In the second step, we first propose the utilization of fully connected layers to enhance the long-term dependence between high-dimensional features of different color spaces; then, a group structure is used to reconstruct specific spacial features. When applied to the UFO dataset, our method improved PSNR by 0.21% and SSIM by 0.1%, compared with the second-best method. Numerous experiments have shown that our TCRN brings competitive results compared with state-of-the-art methods in both qualitative and quantitative analyses.
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Chijioke Mmadueke Okeke and Ukoha Ukoha. "Analysis of craniofacial indices of dry crania in Southeast and Southsouth Nigeria." GSC Biological and Pharmaceutical Sciences 27, no. 1 (April 30, 2024): 035–42. http://dx.doi.org/10.30574/gscbps.2024.27.1.0111.
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Objective: To determine the cranial index, upper facial index and frontal index of dry human crania in Nigeria. Methods: A total of 150 dry adult male crania were studied in two geopolitical zones (Southeast and Southsouth) in Nigeria. Measurements were taken with spreading caliper and Vernier caliper. The following variables were measured: Maximum cranial length (MCL, g-op), Maximum cranial breadth (MCB, eu-eu), Minimum frontal breadth (MFB, ft–ft), Upper facial height (UFH, n-pr) and Bizygomatic breadth (BZB, zy-zy). From these variables, cranial index (CI), frontal index (FI) and upper facial index (UFI) were calculated. Data analysis was done with the Statistical Package for Social Sciences (SPSS version 25). Result: In the Southeast group, the values of MCL, MCB, BZB, UFH and MFB (in mm) were 181.4 (±10.3), 135.3 (±6.7), 135.3 (±6.0), 68.0 (±4.1) and 97.9 (±7.4) respectively. In the Southsouth group, the values of MCL, MCB, BZB, UFH and MFB (in mm) were 180.0 (±7.8), 133.9 (±6.7), 135.0 (±7.2), 67.5 (±6.6), and 98.1 (±4.9) respectively. There was no significant difference in these means between the Southeast and Southsouth groups. In the Southeast group, the mean values of CI, FI and UFI (in %) were 75.1 (±5.9), 72.7 (±5.9), and 50.5 (±3.4) respectively. In the Southsouth group the mean values of CI, FI and UFI (in %) were 74.5 (±4.0), 73.3 (±3.6) and 50.0 (±4.4) respectively. There was no significant difference in the means of the cranial indices among the two groups. Conclusion: The crania in the southern part of Nigeria are dolichocephalic, eurymetopia and mesene type.
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Dutsch, Alexander, Carsten Uhlig, Matthias Bock, Christian Graesser, Sven Schuchardt, Steffen Uhlig, Heribert Schunkert, Michael Joner, Stefan Holdenrieder, and Katharina Lechner. "Multi-Omic Candidate Screening for Markers of Severe Clinical Courses of COVID-19." Journal of Clinical Medicine 12, no. 19 (September 27, 2023): 6225. http://dx.doi.org/10.3390/jcm12196225.
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Background: Severe coronavirus disease 2019 (COVID-19) disease courses are characterized by immuno-inflammatory, thrombotic, and parenchymal alterations. Prediction of individual COVID-19 disease courses to guide targeted prevention remains challenging. We hypothesized that a distinct serologic signature precedes surges of IL-6/D-dimers in severely affected COVID-19 patients. Methods: We performed longitudinal plasma profiling, including proteome, metabolome, and routine biochemistry, on seven seropositive, well-phenotyped patients with severe COVID-19 referred to the Intensive Care Unit at the German Heart Center. Patient characteristics were: 65 ± 8 years, 29% female, median CRP 285 ± 127 mg/dL, IL-6 367 ± 231 ng/L, D-dimers 7 ± 10 mg/L, and NT-proBNP 2616 ± 3465 ng/L. Results: Based on time-series analyses of patient sera, a prediction model employing feature selection and dimensionality reduction through least absolute shrinkage and selection operator (LASSO) revealed a number of candidate proteins preceding hyperinflammatory immune response (denoted ΔIL-6) and COVID-19 coagulopathy (denoted ΔD-dimers) by 24–48 h. These candidates are involved in biological pathways such as oxidative stress/inflammation (e.g., IL-1alpha, IL-13, MMP9, C-C motif chemokine 23), coagulation/thrombosis/immunoadhesion (e.g., P- and E-selectin), tissue repair (e.g., hepatocyte growth factor), and growth factor response/regulatory pathways (e.g., tyrosine-protein kinase receptor UFO and low-density lipoprotein receptor (LDLR)). The latter are host- or co-receptors that promote SARS-CoV-2 entry into cells in the absence of ACE2. Conclusions: Our novel prediction model identified biological and regulatory candidate networks preceding hyperinflammation and coagulopathy, with the most promising group being the proteins that explain changes in D-dimers. These biomarkers need validation. If causal, our work may help predict disease courses and guide personalized treatment for COVID-19.
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Dmitruk, Vadim, Svetlana Khardikova, Marina Gerasimenko, Inna Evstigneeva, and Tatiana Zaitseva. "The effect of the presence of the metabolic syndrome on the efficiency narrow-band uvb ultraviolet radiation (311) in patients with psoriasis." Fizioterapevt (Physiotherapist), no. 3 (June 1, 2020): 48–56. http://dx.doi.org/10.33920/med-14-2006-06.
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Backgraund: the researchers explain the high prevalence of metabolic syndrome among patients with psoriasis by the development of systemic infl ammation, which is considered as a single pathogenetic mechanism in these pathological conditions. The response of patients with psoriasis with metabolic syndrome to treatment with narrowband therapy is currently insuffi ciently studied. Aims: the study evaluated the effi cacy of narrowband therapy (311 nm) in patients with psoriasis associated with metabolic syndrome. Materials and methods: an objective and instrumental examination was conducted in 72 patients diagnosed with psoriasis vulgaris, after which a course of 20 procedures of narrow-cavity medium-wave ultraviolet irradiation (UFO) with a wavelength of 311 nm (B) was conducted. Patients were divided into 2 groups: patients with psoriasis and patients with psoriasis combined with metabolic syndrome. To assess the eff ectiveness of treatment, the index of the area and severity of psoriasis (PASI), lipid and carbohydrate metabolism; insulin and leptin; proinfl ammatory cytokines —IL-1β, IL-8, TNF-α and anti-infl ammatory cytokine IL-10 before and after the 10th, 20th procedure of UV-B therapy and 3 and 6 months after treatment. Results: а signifi cant decrease in PASI was observed in all patients with psoriasis after 10 procedures of UV-B therapy, but in the group of patients with metabolic syndrome, the PASI index was higher. After 20 procedures, Pasi reduction by more than 50 % was observed in the group of patients with psoriasis without manifestations of metabolic syndrome (р < 0,001). Indicators of lipid and carbohydrate blood metabolism in MS patients decreased (р < 0,05), the eff ect remained up to 6 months. The level of proinfl ammatory cytokines was increased in both groups, but in the group of patients with MS these indicators were higher. In the course of therapy cytokines decreased in both groups, the eff ect was maintained up to six months. On the contrary, IL-10 was reduced in both groups, and increased after our treatment, with the prolongation of the eff ect to 6 months. Conclusions: the appointment of UV-B therapy (311 nm) in patients with psoriasis with metabolic syndrome reduces the eff ectiveness of the course in the long term, which apparently requires repeated courses of narrowband therapy after 6 months.
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Davis, R. L., A. Arteaga, and J. F. Hasler. "225 ADDITION OF EQUINE CHORIONIC GONADOTROPIN TO A TRADITIONAL FOLLICLE STIMULATING HORMONE PROTOCOL FOR SUPEROVULATION OF BOS TAURUS BEEF COWS." Reproduction, Fertility and Development 24, no. 1 (2012): 224. http://dx.doi.org/10.1071/rdv24n1ab225.
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This study examined the superovulatory responses of Bos taurus beef cows maintained in a commercial embryo transfer facility. Donors were superovulated 1 to 3 times each with either a traditional 8 injection FSH protocol (controls, n = 126) or 6 injections of FSH with the seventh or eighth FSH treatments replaced by 2 injections of eCG (treatment, n = 134). During the 5-month study, 132 donors were alternatively assigned to a control or treatment group for a single superovulation and an additional 62 animals were superovulated 2 (n = 58) or 3 times (n = 4) in a crossover design. Although 14 beef breeds were represented in the study, 87% of the cows were Angus, Red Angus, Polled Hereford, or Charolais. All donors were synchronized on Day 0 with a CIDR, 5 mg of oestradiol-17β and 100 mg of progesterone. Starting on Day 4 (p.m.), controls were injected twice daily for 4 days with descending doses of porcine FSH (Folltropin-V®, Bioniche Animal Health, Belleville, Ontario, Canada). Cows received 750 μg of cloprostenol (Estrumate®, Intervet Schering-Plough, Summit, NJ, USA) at the seventh FSH injection and the CIDR was removed at the eighth FSH injection. Based on previous experience with specific, individual animals, total FSH dose per donor ranged from 240 to 400 mg. However, 74% of treatments involved 380 mg for controls and 310 mg for treated donors that received eCG. In addition, donors that were superovulated more than once received the same FSH dose in the crossover, treatment-control design. In the treatment group, 200 IU of eCG (Pregnecol™ 6000, Bioniche Animal Health) was substituted for the seventh and eighth FSH injections. Inseminations were conducted on a timed AI basis, with one unit of semen 32 h and a second 48 h following CIDR removal. Results were analysed by ANOVA as shown in Table 1. Although more ova/embryos and unfertilized ova (UFO) were recovered in the control group, the control and treatment groups did not differ in the number of grade 1, 2, or 3 embryos or in the number of degenerate embryos. Previous superovulation studies in South America using eCG to replace the last 2 injections of FSH resulted in more total ova/embryos in Nelore cows but not heifers and in more embryos in Brangus and Sindhi cows. The mean embryo production for the control cows in this study was high and the addition of eCG in the protocol did not improve embryo production. Failure of eCG to increase the number of embryos for Bos taurus cows in this study compared with previous studies may be due to differences with Bos taurus versus Bos indicus breeds or differences in management factors between Canada and South America. The high response rate in the controls may also have contributed to the failure of any advantage of adding eCG to the treatment protocol. Table 1.Mean numbers (± SEM) of ova and embryos recovered from Bos taurus females superovulated with 2 different protocols
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Bader, Christopher D. "Supernatural Support Groups: Who Are the UFO Abductees and Ritual-Abuse Survivors?" Journal for the Scientific Study of Religion 42, no. 4 (December 2003): 669–78. http://dx.doi.org/10.1046/j.1468-5906.2003.00210.x.
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Shafigullina, Z. R., L. I. Velikanova, N. V. Vorokhobina, E. V. Malevanaya, E. G. Strelnikova, and Z. V. Pal’cman. "THE COMBINATION OF CLASSICAL TESTS AND METHODS OF CHROMATOGRAPHY FOR LABORATORY DIAGNOSTICS OF CUSHING’S SYNDROME OF DIFFERENT GENESIS." Russian Clinical Laboratory Diagnostics 65, no. 7 (June 4, 2020): 418–23. http://dx.doi.org/10.18821/0869-2084-2020-65-7-418-423.
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Immunochemical methods of analysis are traditionally used for diagnosis of various forms of Cushing’s syndrome (CS). In the presence of boundary values of hormonal parameters, doubtful situations, a combination of changes both in pituitary and in adrenal glands, it is useful to determine additional differential diagnostic criteria for the diagnosis of various forms of CS. Urinary steroid profiles (USP) were analyzed by gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) for 38 females with adrenal Cushing’s syndrome (CSA), 42 females with pituitary CS (CSP) and 25 healthy females (control group). An increase of free cortisol/free cortisone ratio in the urine (UFF/UFE) for CSP patients in comparison of CSA was obtained by HPLC method. Decreased urinary excretion of UFF and UFE by more than 60% after the 8 mg dexamethasone suppression test had 100% sensitivity and specificity of more than 90% for the diagnosis of CSP. GC-MS method in patients with CSA and CSG revealed the peculiarities of androgens, progestins and glucocorticoids metabolism which leaded to obtain specific USP for CS of different genesis. Increased urinary excretions of dehydroepiandrosterone and its metabolites, metabolites of androstenedione, the ratio of sum of cortisol and cortisone tetrahydrometabolites to tetrahydro-11-deoxycortisol (more then 36) in CSP patients compared with CSA are additional signs for differential diagnosis of these diseases. The combination of classical tests and USP obtained by HPLC and GC-MS methods increased the sensitivity and specificity of differential diagnosis of CSA and CSP.
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Jasim, Hassan Saad, and Zainab Z. Ismail Ismail. "The Potential of Recycling Used Engine Oil for Biogas Generation by Co-Digestion with Animals’ Manure: Experimental and Kinetic Study." Journal of Engineering 29, no. 7 (July 1, 2023): 34–47. http://dx.doi.org/10.31026/j.eng.2023.07.03.
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This study investigates the potential of biogas recovery from used engine oil (UEO) by co-digestion with animals’ manure, including cow dung (CD), poultry manure (PM), and cattle manure (CM). The experimental work was carried out in anaerobic biodigesters at mesophilic conditions (37°C). Two groups of biodigesters were prepared. Each group consisted of 4 digesters. UEO was the main component in the first group of biodigesters with and without inoculum, whereby a mix of UEO and petroleum refinery oily sludge (ROS) was the component in the second group of biodigesters. The results revealed that for UEO-based biodigesters, maximum biogas production was 0.98, 1.23, 1.93, and 0 ml/g VS from UEO±CD, UEO±CM, UEO±PM, and UEO, respectively, whereby, for the UEO=ROS-based biodigesters, maximum biogas production was 3.49, 2.47, 3.64 and 2.44 ml/g VS from UEO+ROS±CD, UEO+ROS±CM, UEO+ROS±PM, and UEO+ROS, respectively. These results indicated that UEO was not feasible and efficient for biogas recovery since biogas production was very low in the first group of biodigesters compared to its recovery in the second group. A modified Gompertz model was applied to study the kinetics of the bio-digestion process. Measured and predicted values of biogas generation were fitted well with determination coefficients higher than 0.92.
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Vidal, Creto Augusto, and Joaquim Bento Cavalcante-Neto. "UFC-CRAb: A group on Computer graphics, virtual Reality and Animation." Journal on Interactive Systems 2, no. 2 (November 16, 2011): 1. http://dx.doi.org/10.5753/jis.2011.591.
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Lai, Y.-C., H.-L. Kao, Y.-H. Lin, M.-S. Lin, Y.-L. Ho, and C.-L. Chao. "The Angio-Seal™ Arterial Closure Device for Early Ambulation after Elective Percutaneous Coronary Intervention in Patients Receiving Low-Dose Enoxaparin." Journal of International Medical Research 36, no. 5 (October 2008): 1077–84. http://dx.doi.org/10.1177/147323000803600527.
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This study evaluated the efficacy and safety of use of the Angio-Seal™ vascular closure device deployment for early ambulation (2 h) after elective percutaneous coronary intervention in 143 consecutive patients receiving either intravenous low-dose enoxaparin (0.5 mg/kg) or unfractionated heparin (UFH). The initial success rate of Angio-Seal™ deployment was 98.6%, with no significant difference between the UFH group (98.9%) and the enoxaparin group (98.0%). In-hospital and clinic outcomes were evaluated in the 141 patients with successful Angio-Seal™ deployment. During hospitalization, there were no deaths, myocardial infarction, urgent target vessel revascularization or bleeding events in either group; three patients in the UFH group and none in the enoxaparin group had minor vascular complications (differences not significant). In clinic follow-up, two patients in the UFH group and none in the enoxaparin group had major vascular complications (differences not significant). Routine use of the Angio-Seal™ for early ambulation in patients receiving intravenous low-dose enoxaparin compared with UFH provides promising efficacy and safety for daily practice.
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Wauters, Paul. "The semicentre of a group algebra." Proceedings of the Edinburgh Mathematical Society 42, no. 1 (February 1999): 95–111. http://dx.doi.org/10.1017/s0013091500020046.
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We study the semicentre of a group algebra K[G] where K is a field of characteristic zero and G is a polycyclic-by-finite group suchthat Δ(G) is torsion-free abelian. Several properties about the structure of this ring are proved, in particular as to when is the semicentre a UFD. Examples are constructed when this is not the case. We also prove necessary and sufficient conditions for every normal element of K[G] which belongs to K[Δ(G)] to be the product of a unit and a semi-invariant.
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Crannage, Andrew J., and Julie A. Murphy. "Evaluation of the Implementation of an Anticoagulation Management Protocol at a Community Hospital." Journal of Pharmacy Practice 24, no. 4 (June 6, 2011): 404–8. http://dx.doi.org/10.1177/0897190011406124.
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Purpose: The objective of this study was to evaluate the impact of implementation of an anticoagulation protocol involving dosing and monitoring of unfractionated heparin (UFH) and low-molecular-weight heparin, specifically enoxaparin, for the treatment of deep vein thrombosis (DVT), pulmonary embolism (PE), and/or acute coronary syndromes (ACS). Methods: Patients with a primary diagnosis of DVT, PE, and/or ACS treated with UFH and/or enoxaparin were included. Data were collected on patients admitted to a community hospital during February 2008 (preimplementation) and February 2009 (postimplementation). Results: Forty-six patients were included in the preimplementation group and 25 patients in the postimplementation group. Forty-six percent of patients were dosed properly in the preimplementation group (UFH 38% and enoxaparin 50%) compared to 76% in the postimplementation group (UFH 56% and enoxaparin 88%; P = .023). Fifty-four percent of patients were monitored properly in the preimplementation group (UFH 31% and enoxaparin 67%) compared to 68% in the postimplementation group (UFH 56% and enoxaparin 75%; P = .318). Conclusion: Standardized dosing with a multidisciplinary-managed anticoagulation protocol significantly increased proper dosing of anticoagulation therapy; however, the protocol did not significantly improve proper monitoring. A lack of understanding of the need for baseline laboratory data contributes to improper monitoring. An approach which includes significant educational strategies is necessary to optimize patient care.
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Shi, Shutian, Lei Zhen, Mei Wang, Chunmei Wang, Hui Ai, Bin Que, and Shaoping Nie. "Effects of early application of heparin on coronary blood flow during primary percutaneous coronary intervention." Tropical Journal of Pharmaceutical Research 22, no. 8 (September 15, 2023): 1691–98. http://dx.doi.org/10.4314/tjpr.v22i8.21.
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Purpose: To investigate the efficacy and safety of unfractionated heparin (UFH) anticoagulant administered upstream in the ambulance or emergency room during primary percutaneous coronary intervention (pPCI) for patients with acute ST-segment elevation myocardial infarction (STEMI).Methods: The study included STEMI patients who received either early UFH subcutaneously (SC) (n = 163) or intraoperative UFH (SC) during pPCI (n = 476) between January 2017 to August 2018. Baseline characteristics, infarct-related artery (IRA) status, and procedural characteristics were analyzed. The primary endpoint was thrombolysis in myocardial infarction (TIMI) flow grade 2 - 3 before intervention. The secondary endpoints were time from first medical contact to guidewire passage, postoperative TIMI 3 flow grade, acute stent thrombosis, and in-hospital bleeding events.Results: Baseline characteristics were similar between the groups, with no significant difference in IRA location. Both groups underwent coronary angiography, with most patients receiving pPCI. The primary endpoint occurred in 18.1 % of patients in intraoperative UFH group and 27.6 % in the early UFH group, with a significant difference between the groups (p < 0.05). There was no significant difference in postoperative TIMI 3 flow grade or acute stent thrombosis, but bleeding events (BARC 2-5) were similar between groups (1.1 % in intraoperative group and 1.8 % in early UFH group, p > 0.05)Conclusion: Early upstream administration of UFH anticoagulation in STEMI patients improves coronary artery potency before pPCI, and early use of fixed-dose UFH is safe and does not increase major bleeding complications.
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Soylu Özler, Gül, and Serkan Özler. "Coexistence of Upper Airway Obstruction and Primary and Secondary Enuresis Nocturna in Children and the Effect of Surgical Treatment for the Resolution of Enuresis Nocturna." Advances in Medicine 2014 (2014): 1–4. http://dx.doi.org/10.1155/2014/656431.
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Objective.The aim of this study is to investigate the coexistence of upper airway obstruction (UAO) and primary enuresis nocturna (PEN) and secondary enuresis nocturna (SEN) in children. Besides, the efficacy of surgery on resolution of enuresis nocturna is evaluated.Materials and Methods.The children with PEN and SEN were included in the first group and investigated for UAO in the Department of Otorhinolaryngology. During the same period, children who had been planned for an operation to treat UAO over 5 years old were included in the second group and were evaluated in the Department of Urology for PEN and SEN before the operation.Results.A hundred patients completed the study (50 patients in Group 1, 50 patients in Group 2). According to the otolaryngologic examination, 20 of 25 PEN patients and 9 of 25 SEN patients also had UAO. The difference was statistically different (P<0.05). The second group consisted of fifty patients on the surgery list for upper airway obstructive pathologies. Coexistence of PEN and SEN is found in 12 and 3 of children, respectively. These ratios were statistically significant (P<0.05). The improvement rate of PEN and SEN after operation in the second group was 83.3% and 33.3%, respectively. The difference was statistically significant (P<0.05).Conclusion.There is a strong relationship between PEN and UAO, but it cannot be declared for SEN patients. UAO should be kept in mind as a possible etiologic factor for PEN.
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Yang, Zhantao, Siyuan Liu, Tian Xie, Qianqian Wang, Zhonghan Wang, Hongjian Yang, Shengli Li, and Wei Wang. "Effect of Unsaturated Fatty Acid Ratio In Vitro on Rumen Fermentation, Methane Concentration, and Microbial Profile." Fermentation 8, no. 10 (October 14, 2022): 540. http://dx.doi.org/10.3390/fermentation8100540.
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It is well known that dairy cows are fed diets with high fat content, which can adversely affect rumen fermentation. However, whether the effects of high fat content on rumen fermentation are related to the composition of fatty acids (FA) is for further study. We explored the effects of unsaturated fatty acid (UFA) ratios in vitro on rumen, methane concentration and microbial composition under the same fat levels. The experiment included a low-unsaturated group (LU, UFA proportion: 42.8%), a medium-unsaturated group (MU, UFA proportion: 56.9%), and a high-unsaturated group (HU, UFA proportion: 70.9%). The incubation fluid pH and NH3-N levels were not significantly different in the three groups. Total volatile fatty acid (TVFA), acetate, propionate, butyrate, and valerate in the MU group had a decreased trend compared to the LU group (0.05 < p < 0.1), and no difference was found in other volatile fatty acids (VFAs) among the three groups. Furthermore, gas production kinetic parameters among the three groups did not differ significantly. The LU group’s CH4 concentration was significantly higher than the HU group (p < 0.05). The CO2 concentration in the LU group was also significantly higher than the MU and LU groups (p < 0.05). Additionally, 16S rRNA microbial sequencing results showed that the Shannon diversity value significantly increased in the MU group (p < 0.05) compared to the LU group. Other alpha diversity indices (Chao 1, observed species, and ACE) did not differ among the three groups. The increased proportion of UFA significantly decreased the relative abundance of Succinivibrionaceae_UCG_001 and Fibrobacter (p < 0.05). Meanwhile, the multiple Lachnospiraceae bacteria significantly increased in the MU group (p < 0.05). Overall, our findings indicated that the microbial community in the incubation system could be affected by elevating proportions of UFA, affecting the yield of VFA, whereas the CH4 concentration was reduced.
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Lopes, Daniela Machado, Ana Rodríguez-Carmona, Teresa García Falcón, Andrés López Muñiz, Tamara Ferreiro Hermida, Antía López Iglesias, and Miguel Pérez Fontán. "Analysis of Ultrafiltration Failure Diagnosed at the Initiation of Peritoneal Dialysis with the Help of Peritoneal Equilibration Tests with Complete Drainage at Sixty Minutes. A Longitudinal Study." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 36, no. 4 (July 2016): 442–47. http://dx.doi.org/10.3747/pdi.2015.00163.
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BackgroundUltrafiltration failure (UFF) diagnosed at the initiation of peritoneal dialysis (PD) has been insufficiently characterized. In particular, few longitudinal studies have analyzed the time course of water transport in patients with this complication.ObjectiveTo investigate the time course of peritoneal water transport during the first year on PD in patients presenting UFF since the initiation of this therapy (study group).MethodProspective, observational, single-center design. We analyzed, at baseline and after 1 year of follow-up, peritoneal water transport in 19 patients incident on PD with UFF. We used incident patients without UFF as a control group. Water transport was characterized with the help of 3.86/4.25% dextrose-based peritoneal equilibration tests (PETs) with complete drainage at 60 minutes.ResultsThe study group revealed a disorder of water transport affecting both small-pore ultrafiltration (SPUF) ( p = 0.054 vs incident without UFF) and free water transport (FW T) ( p = 0.001). After 1 year of follow-up, FWT displayed a general increasing trend in the study group (mean variation 48.9 mL, 95% confidence interval [CI] 15.5, 82.2, p = 0.012), while the behavior of SPUF was less predictable (-4.8 mL, 95% CI -61.4, 71.1, p = 0.85). These changes were not observed in incident patients without UFF. Neither initial clinical characteristics, baseline PET-derived parameters, or suffering peritoneal infections during the first year predicted the time course of the capacity of UF in the study group. Recovery from incident UFF was apparently linked to improvement of SPUF.ConclusionsPatients with UFF at the start of PD suffer a disorder of peritoneal water transport affecting both FWT and SPUF. Free water transport increases systematically in these patients after 1 year of follow-up. The evolution of SPUF is less predictable, and improvement of this parameter marks reversibility of this complication.
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Chrysavgi Kamilaris, Crystal Dawn, Ninet Sinaii, and Constantine A. Stratakis. "Selective Serotonin Reuptake Inhibitors Increase Urinary Free Cortisol in Patients with Carney Complex and Primary Pigmented Nodular Adrenocortical Disease." Journal of the Endocrine Society 5, Supplement_1 (May 1, 2021): A95. http://dx.doi.org/10.1210/jendso/bvab048.190.
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Abstract Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of ACTH-independent Cushing syndrome predominantly associated with Carney Complex (CNC), a multiple endocrine neoplasia syndrome primarily caused by inactivating defects in PRKAR1A. PPNAD, which has neuroendocrine features, demonstrates cortisol production in response to serotonin as well as increased expression of tryptophan hydroxylase type 2, a serotonin synthesizing enzyme, and the serotonin (5-HT) receptors types 4, 6, and 7. This creates an autocrine/paracrine serotonergic regulatory loop that activates cortisol production. PPNAD can be diagnosed through a 6-day Liddle test (LT) showing a paradoxical increase of >50% from baseline in 24-h urinary free cortisol (UFC) on the 2nd day of high-dose dexamethasone administration (Day 6). Selective serotonin reuptake inhibitors (SSRIs) inhibit the reuptake of serotonin and are widely used for the treatment of depression. We performed a retrospective cohort study of patients with CNC and PPNAD that underwent a LT to evaluate the effect of SSRIs on UFCs, with the hypothesis that SSRI use leads to an exaggerated increase in UFC through presumed activation of the described serotonergic regulatory loop. Of the 34 patients (4–65 y) with CNC and PPNAD that underwent a LT at our institution between 2004 and 2018, 4 took an SSRI during testing. No differences were observed between the SSRI (S) group and the non-SSRI (NS) group in baseline UFCs and the percent increase in UFC on D6. Specifically, the median (IQR) baseline UFC in the S group was 36 (13–252) mcg/24h (nl 4–56) vs 35 (13–98) mcg/24h in the NS group (P=0.95). The percent change in UFC was 208 (93–683)% in the S group and 185 (28–364)% in the NS group (P=0.89). However, there was a difference for overall UFC measurement (across days 1–6 of the LT) in the S group vs the NS group (P=0.03). Age <18 vs 18+ and sex did not have an effect on the outcomes (P=0.17 and P=0.74, respectively). Thus, we conclude that though the percent change in UFC during the LT was similar in both groups, there was a significant difference in overall UFC in the S group when compared to the NS group. These data support an effect of SSRIs and serotonin on UFC and consequently cortisol production in PPNAD. This interesting observation has to be confirmed in more patients with CNC and PPNAD to further elucidate the effects of SSRIs on cortisol production in patents with PPNAD-caused Cushing syndrome, as this may have significant diagnostic and therapeutic implications.
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Huang, Lin, Guixia Wei, Nan Chen, Jiewei Liu, Ziqiang Wang, Yongyang Yu, and Meng Qiu. "Impact of Upfront Chemotherapy on the Effect of Primary Tumour Resection for Asymptomatic Synchronous Colorectal Cancer With Unresectable Metastases: A Propensity-Score-Matched Cohort Analysis." Clinical Medicine Insights: Oncology 16 (January 2022): 117955492210850. http://dx.doi.org/10.1177/11795549221085054.
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Background: It is controversial whether primary tumour resection (PTR) and the sequencing of chemotherapy and PTR are associated with the survival of patients with incurable stage IV colorectal cancer. This study aimed to explore the effects of PTR and the sequencing of chemotherapy and PTR on asymptomatic colorectal cancer with synchronous unresectable metastases (asmCRC). Patients and Methods: Patients with asmCRC were retrospectively identified from a single centre and categorised into 3 groups: PTR followed by chemotherapy (POC), upfront chemotherapy followed by PTR (UFC), and palliative chemotherapy (PC). The primary end points included median overall survival (OS) and progression-free survival (PFS). Clinical features were analysed using χ2 test, while survival curves were generated using the Kaplan-Meier test. Propensity-score matching (PSM) was performed when comparing survival between POC and UFC groups. Results: From 2008 to 2014, 255 patients were identified and included into the POC (n = 101), UFC (n = 40), and PC (n = 114) groups. The UFC and POC groups had significantly better median OS compared with the PC group (40.7 vs 16.3 months, P < .0001; 39.7 vs 16.3 months, P < .0001). Before PSM, the UFC group had better median PFS than the POC and PC groups (18.5 vs 9.7 months, P = .038; 18.5 vs 6.1 months, P < .0001). After PSM, UFC has better PFS than POC ( P = .038). And the UFC group did not have higher postoperative or preoperative morbidity compared with the POC group ( P = .235). Conclusions: Primary tumour resection could improve the survival of patients with asmCRC. Compared with POC or PC, UFC was associated with a better median PFS without significantly increasing preoperative or postoperative morbidity.
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Liu, Zijing, Guozhong Wang, Dan Niu, Yongxia Wu, Zixuan Li, Libin Zhang, Guohua Zhu, Qi Hua, and Jincheng Guo. "Bivalirudin vs. Heparin on Radial Artery Thrombosis during Transradial Coronary Intervention: An Optical Coherence Tomography Study." Journal of Interventional Cardiology 2020 (September 26, 2020): 1–8. http://dx.doi.org/10.1155/2020/7905021.
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Objectives. This study aimed to evaluate the antithrombotic efficacy between bivalirudin and unfractionated heparin (UFH) on radial artery thrombosis (RAT) during transradial coronary intervention (TRI) by optical coherence tomography (OCT). Methods and Results. We consecutively reviewed a total of 307 patients who underwent radial artery OCT inspection after TRI in our centre from October 2017 to January 2019; afterwards, 211 screened patients were divided into the UFH group (n = 144) and the bivalirudin group (n = 67) according to their anticoagulation strategy during TRI. The thrombosis in the radial artery was observed in 51 cases (24.17%) with a median thrombus volume of 0.054 mm3 (0.024, 0.334) and median thrombus score of 7 (4, 15). Thrombus occurred in 28 cases in the bivalirudin group with an incidence of 41.8%, which was significantly higher than that in the UFH group (n = 23, 16.0%, P<0.001). This difference was even more remarkable after propensity score matching (bivalirudin group n = 22, 42.3% vs. UHF group n = 11, 13.9%, P<0.001). Multivariate logistic analysis revealed that bivalirudin increased the RAT risk by 3.872 times (95% CI 2.006–8.354, P<0.001) after adjustment for the other predictors. Conclusion. In this present study, the use of bivalirudin was associated with a higher risk of RAT than UFH. It highlighted UFH should be a more considerable choice to prevent radial artery access thrombosis in TRI.
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Zhang, Heng, Yini Sun, Xin An, and Xiaochun Ma. "Unfractionated Heparin Improves the Intestinal Microcirculation in a Canine Septic Shock Model." Mediators of Inflammation 2021 (June 23, 2021): 1–11. http://dx.doi.org/10.1155/2021/9985397.
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Background. Alterations of microcirculation are associated with organ hypoperfusion and high mortality in septic shock. This study is aimed at investigating the effects of unfractionated heparin (UFH) on intestinal microcirculatory perfusion and systemic circulation in a septic shock model. Methods. Twenty-four beagle dogs were randomly allocated into four groups: (a) sham group: healthy controls, (b) shock group: septic shock induced by Escherichia coli, (c) basic therapy group: septic shock animals treated with antibiotics and 10 ml/kg/h saline, and (d) heparin group: septic shock animals treated with basic therapy plus UFH. Hemodynamic variables were measured within 24 h after E. coli administration. The intestinal microcirculation was simultaneously investigated with a sidestream dark-field imaging technique. Additionally, the function of vital organs was evaluated at 12 h postadministration (T12). Results. E. coli induced a progressive septic shock in which the mean arterial pressure (MAP) decreased and lactate levels sharply increased, accompanied by deteriorated microvessel perfusion. While basic therapy partially improved the microvascular flow index and the perfused microvessel density in the jejunal villi, UFH significantly restored major microcirculation variables at T12. Physiological variables, including MAP, urine output, and lactate levels, were improved by UFH, whereas some hemodynamic indices were not affected by UFH. With respect to organ function, UFH increased the platelet count and decreased the creatinine level. Conclusions. UFH improves microcirculatory perfusion of the small intestine independently of the changes in systemic hemodynamic variables in a canine model of septic shock, thereby improving coagulation and renal function.
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Haftmann, Richard J., Erika May Pineda, Brent A. Hall, Machelle D. Wilson, and Stephanie N. Mateev. "Comparison of Time Within Therapeutic Range Using Anti-Factor Xa Versus Activated Partial Thromboplastin Time Monitoring of Unfractionated Heparin in Children." Journal of Pediatric Pharmacology and Therapeutics 28, no. 3 (May 1, 2023): 228–34. http://dx.doi.org/10.5863/1551-6776-28.3.228.
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OBJECTIVE To compare unfractionated heparin (UFH) monitoring using time in therapeutic range of activated partial thromboplastin time (aPTT) versus anti-factor Xa activity (anti-Xa) in children. METHODS This retrospective chart review, with data between October 2015 and October 2019, included pediatric patients younger than 18 years on therapeutic UFH infusion with aPTT or anti-Xa monitoring. Patients receiving extracorporeal membrane oxygenation, dialysis, concomitant anticoagulants, prophylactic UFH, no stated goal, and UFH administered for less than 12 hours were excluded. The primary outcome compared the percentage of time in therapeutic range between aPTT and anti-Xa. Secondary outcomes included time to first therapeutic value, UFH infusion rates, mean rate adjustments, and adverse events. RESULTS A total of 65 patients were included, with 33 aPTT patients and 32 anti-Xa patients, representing 39 UFH orders in each group. Baseline characteristics were similar between groups, with an overall mean age of 1.4 years and mean weight of 6.7 kg. The anti-Xa cohort demonstrated a statistically significantly higher percentage of time in therapeutic range compared with the aPTT group (50.3% vs 26.9%, p = 0.002). The anti-Xa group also demonstrated a trend toward decreased time to first therapeutic value compared with aPTT (14 vs 23.2 hours, p = 0.12). Two patients in each group experienced new or worsening thrombosis. Six patients in the aPTT cohort experienced bleeding. CONCLUSIONS This study demonstrated greater time was spent within therapeutic range for children receiving UFH monitored with anti-Xa compared with aPTT. Future studies should assess clinical outcomes in a larger population.
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De Sousa, Erika, Gloria Del Peso, Laura Alvarez, Silvia Ros, Ana Mateus, Ana Aguilar, Rafael Selgas, and María-Auxiliadora Bajo. "Peritoneal Resting with Heparinized Lavage Reverses Peritoneal Type I Membrane Failure. A Comparative Study of the Resting Effects on Normal Membranes." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 34, no. 7 (November 2014): 698–705. http://dx.doi.org/10.3747/pdi.2013.00286.
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BackgroundUltrafiltration failure (UFF) is a serious complication of long-term peritoneal dialysis (PD). Peritoneal rest (PR) has been demonstrated as a valid treatment to reverse the functional changes that occur in UFF. The effects of PR on a normally functioning human peritoneum are unknown but are expected to be neutral. Our hypothesis was that PR positively modifies peritoneal function in patients with UFF, in contrast to the absence of effects when PR is applied under normal conditions.Patients and MethodsWe studied 84 PR periods, comparing 35 patients with UFF and 49 controls (resting for abdominal surgery with temporary discontinuation of PD). We analyzed peritoneal transport pre-PR and post-PR by calculating the mass transfer coefficients of creatinine (Cr-MTAC), the dialysate/plasma creatinine ratio (D/P Cr) and the ultrafiltration (UF).ResultsBaseline data was similar for the 2 groups, although the UFF group had a longer median time in PD (39 [18 – 60] vs 10 [5 – 23] months; p = 0.00001). Peritoneal rest induced a decrease in D/P Cr, Cr-MTAC and an increase in UF capacity in the UFF group ( p = 0.0001, p = 0.004 and p = 0.001, respectively), without causing changes in the control group. Peritoneal rest in patients with more than 6 months of UFF was not able to reduce peritoneal solute transport or improve UF capacity. Response to PR did not differ among UFF patients with or without a previous history of peritonitis. Peritoneal rest enabled patients with UFF to continue on PD for a median time of 23 months (range, 13 – 46 months).ConclusionsPeritoneal rest induces functional changes in patients with UFF but not in those with no functional abnormalities. This demonstrates that PR works only when abnormal but reversible functional conditions are present. However, the effect is highly dependent on how early PR is applied.
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Mudra, I. "Linkedin Social Network: Benefits and Prospects for the Media." State and Regions. Series: Social Communications, no. 3(51) (November 24, 2022): 88. http://dx.doi.org/10.32840/cpu2219-8741/2022.3(51).12.
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<p><strong><em>The purpose of the study. </em></strong><em>To identify the features of the social network LinkedIn and find out its</em><em> prospects for use to promote media content and image.</em></p><p><strong><em>Research methodology.</em></strong><em> The research used general scientific methods: generalization, synthesis, analysis, comparison, abstraction, and typology, which allowed us to analyze the social network LinkedIn, as well as to determine its benefits for promoting media content and image formation. To search for media that use the social network LinkedIn to promote their content and image, we used the internal search of the selected social network. During the research it was found that LinkedIn actively maintains its pages of 2 media groups – Media Group Ukraine LLC (TV channels «Ukraine», «Ukraine 24», «UFO TV», «Indigo TV», «Football 1/2/3», Ukraine 1 / Ukraine 2, NLO TV 2, «34 TV Channel» and others) and 1+1 media (TV channels «1+1», «2+2», «TET», «PlusPlus», <br /> «1+1 International», «Union TV», «Curlers» and others). Accounts of Ukrainian TV channels, radio, magazines, and newspapers were also found on LinkedIn.</em></p><p><strong><em>Results</em></strong><strong><em>.</em></strong><em> The LinkedIn social network is a promising platform primarily for shaping the image of the media in general, and not just as a successful employer. As well as many foreign media use it to inform subscribers and increase traffic to the media site. LinkedIn media is used for various purposes. It is also convenient to use to keep abreast of all innovations in the media market and monitor the success of competitors.</em></p><p><strong><em>Novelty.</em></strong><em> The LinkedIn social network is considered a professional social platform, it is often identified as a platform for finding employees. Ukrainian mass media are reluctant to create accounts and publish content in it. Even though it can be a promising platform for them to form the image of the media, not only as a reliable employer but also as a successful media. We came to this decision after analyzing the pages of Ukrainian and foreign media on the social network LinkedIn. Also, while searching for research on a given topic, we could not find the works of Ukrainian scientists who would consider LinkedIn as a platform for promoting media content and image formation. This topic is also not popular and well-developed among foreign scholars.</em></p><p><strong><em>Key words:</em></strong><em> social networks, LinkedIn, image formation, content promotion, mass media.</em></p>
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Lopaciuk, S., A. J. Meissner, S. Filipecki, K. Zawilska, J. Sowier, L. Ciesielski, M. Bielawiec, S. Glowinski, and E. Czestochowska. "Subcutaneous Low Molecular Weight Heparin versus Subcutaneous Unfractionated Heparin in the Treatment of Deep Vein Thrombosis: a Polish Multicenter Trial." Thrombosis and Haemostasis 68, no. 01 (1992): 014–18. http://dx.doi.org/10.1055/s-0038-1656309.
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SummaryIn a prospective multicenter trial, 149 consecutive patients with phlebographically proven proximal and/or distal deep vein thrombosis of the leg were randomly allocated to receive subcutaneously for 10 days either low molecular weight heparin CY 216 (Fraxiparine) in a fixed dose or unfractionated heparin (UFH) in doses adjusted according to the activated partial thromboplastin time. Pre- and post-treatment phlebograms were assessed blindly using the Arnesen’s score system in 134 patients available for analysis of the treatment efficacy. The mean phlebographic score after 10 days of treatment was significantly decreased in both groups (p <0.001) in comparison with the baseline score but the difference in score changes between the two groups was not statistically significant. There was an improvement in 45/ 68 patients (66%) in the Fraxiparine group and in 32/66 patients (48%) in the UFH group, and an increase in the thrombus size in 10/68 (15%) and 12/66 (18%), respectively. One symptomatic non-fatal pulmonary embolism and one major bleeding episode were observed in the UFH group. During a follow-up period of 3 months, two rethromboses had occurred in the UFH group and none in the Fraxiparine group. It is concluded that subcutaneous fixed dose Fraxiparine is safe and at least as effective as subcutaneous adjusted UFH in the treatment of deep vein thrombosis.
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Bergmann, Jean-Fraçois, and Eric Neuhart. "A Multicenter Randomized Double-blind Study of Enoxaparin Compared with Unfractionated Heparin in the Prevention of Venous Thromboembolic Disease in Elderly In-patients Bedridden for an Acute Medical Illness." Thrombosis and Haemostasis 76, no. 04 (1996): 529–34. http://dx.doi.org/10.1055/s-0038-1650617.
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SummaryA multicenter, randomized double-blind study compared in two parallel groups the efficacy and safety of a low molecular weight heparin (LMWH) enoxaparin 20 mg once daily, with unfractionated heparin (UFH) 5000 IU twice daily, administered subcutaneously for 10 days, in the prevention of venous thrombosis disease in 442 hospitalized elderly patients bedridden for an acute medical illness. The main efficacy endpoint was defined as the occurrence of venous thrombosis, diagnosed by a daily fibrinogen uptake test, and/or documented clinical pulmonary embolism.Intention-to-treat analysis of efficacy showed that the incidence of venous thromboembolic events was low: 4.8% (10/207) in the LMWH group (9 episodes of isotopic venous thrombosis and one of scintigraphic pulmonary embolism), and 4.6% (10/216) in the UFH group (10 episodes of isotopic venous thrombosis). The two treatments were equivalent, where equivalence was defined as a maximum difference of 7% between the two groups (p = 0.0005).There were no significant differences in terms of safety between the 216 patients in the LMWH group and the 223 patients in the UFH group who received at least one injection of the randomized treatment. During the study period, 15 patients (3.4%) died (7 in the LMWH group and 8 in the UFH group): 2 sudden deaths, one in each group, including one case in which pulmonary embolism could not be excluded since no autopsy was performed, and 13 others deaths unrelated to the study treatments. Six patients (1.4%) presented a bleeding complication: 2 (0.9%) in the enoxaparin group (one major and one minor hemorrhage), and 4 (1.8%) in the UFH group (2 major and 2 minor hemorrhages).These results indicate that subcutaneous enoxaparin 20 mg once daily for 10 days is as effective and well tolerated as subcutaneous UFH 5000 IU twice daily in the prevention of venous thromboembolic disease in bedridden elderly in-patients presenting an acute medical illness.
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Bratt, Göran, Eva Törnebohm, Staffan Granqvist, Wiveca Åberg, and Dieter Lockner. "A Comparison Between Low Molecular Weight Heparin (KABI 2165) and Standard Heparin in the Intravenous Treatment of Deep Venous Thrombosis." Thrombosis and Haemostasis 54, no. 04 (1985): 813–17. http://dx.doi.org/10.1055/s-0038-1660139.
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SummaryIn order to study whether a low molecular weight heparin (LMWH) of mw 4000 D is effective in the treatment of deep venous thrombosis (DVT), patients with DVT verified by phlebography were randomized to treatment by continuous intravenous infusion of either unfractionated heparin (UFH) or LMWH. The initial dose was 240 U (anti F Xa)/kg/12 h. TTiis study (study I) was stopped because of major bleeding in 2 newly operated patients in the LMWH group after 27 patients had been treated. The heparin activity measured as F Xa inhibition assayed in retrospect, was found to be much higher in the LMWH group (mean 1.6-2.0 anti F Xa U/ml) than in the UFH group (mean 0.5-0.8 anti F Xa U/ml).A second study was therefore initiated in which the DVT patients were randomly given UFH (240 U/kg/12 h) or LMWH only 120 U (anti F Xa)/kg/12 h, as initial doses (study II). In this study 27 patients could be evaluated, the mean heparin activity still being higher in the LMWH group (0.9-1.2 anti F Xa U/ml) than in the UFH group (0.5-0.7 anti F Xa U/ml).A second phlebographic investigation showed progression of thrombus size in 3 (11%) of the UFH patients of studies I and II (n = 29) and improvement in 14 (48%). There was no progression in any LMWH patient, 6 (50%) had improved in study I and 10 (77%) in study II. The mean decrease of thrombus size score (according to Marder) during treatment did not differ between the 3 groups.Antithrombin III decreased significantly in the UFH group but not in the LMWH groups. Aminotransferases increased in all 3 groups. There was no difference in mean capillary bleeding time between the 3 treatment groups.Although this material is relatively small, our findings suggest that LMWH seems to be of similar effectivity as UFH.
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Deliargyris, Efthymios N., Bharathi Upadhya, Laura G. Melton, Cheryl Thompson, Melrose Fisher, Don A. Gabriel, Gregory J. Dehmer, and David C. Sane. "Unfractionated Heparin Reduces the Anti-Platelet Effects of Abciximab but not Eptifibatide During PCI." Clinical and Applied Thrombosis/Hemostasis 12, no. 4 (October 2006): 458–64. http://dx.doi.org/10.1177/1076029606293432.
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In 29 patients undergoing percutaneous coronary intervention (PCI), we obtained blood samples at baseline, 10 minutes after standard weight-based abciximab (n=15) or double-bolus eptifibatide (n=14) and 5 minutes after unfractionated heparin (UFH; 70 U/kg bolus). The median percent inhibition was significantly higher in the eptifibatide group compared with the abciximab group both before (96.5% [94-100] vs. 85% [77-89.5] [adenosine diphosphate; ADP]; 89.5% [84-95] vs. 59% [37.5-76.5] [thrombin receptor agonist peptide; TRAP], p<0.001 for both) and after UFH (95% [93-100] vs. 79% [68.8-87.5] [ADP]; 82% [77-93] vs. 51% [34.5-71.3] [TRAP], p<0.001 for both). Addition of UFH significantly reduced platelet inhibition in the abciximab group (85% [77-89.5] vs. 79% [68.8-87.5] [ADP]; 59% [37.5-76.5] vs. 51% [34.5-71.3] [TRAP], p<0.05 for both) but not in the eptifibatide group (96.5% [94-100] vs. 95% [93-100] [ADP]; 89.5% [84-95] vs. 82% [77-93] [TRAP], p=ns for both). Eptifibatide achieved superior platelet inhibition before but especially after UFH compared with abciximab.
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Despotovic, Nebojsa, Goran Loncar, Maja Nikolic-Despotovic, Marjan Ilic, and Sinisa Dimkovic. "The safety of enoxaparine use in elderly with acute myocardial infarction." Vojnosanitetski pregled 64, no. 10 (2007): 655–58. http://dx.doi.org/10.2298/vsp0710655d.
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Background/Aim. Enoxaparin (ENOX), the lowmolecular- weight heparin, used in acute myocardial infarction (AMI) could lead to hemorrhage. The aim of this study was to determine whether bleeding was more often in AMI patients older than 65 or 75 years who receive ENOX or unfractionated heparin (UFH). Methods. Among the patients with AMI hospitalized during three successive months receiving ENOX or UFH, three group of parameters were investigated: demographic, ischemic and bleeding TIMI criteria. Results. Among 85 hospitalized patients with signs of AIM, there were 35 (41.2%) old 65 years or less, 32 (38.5) old 66-75 years and 18 (21.2%) older than 75 years. In AMI elderly patients, according to the received ENOX/UFH: ischemic complication (18.2 vs. 21.4%) were insignificantly lower and the number of lethal outcomes (18,2 vs. 17,8%) were insignificantly more often in ENOX group; represented only by one patient (age beyond 75 years), major and non-major bleeding events occurred only in UFH group. Conclusion. The ENOX usage in AMI in patients older than 65 years did not show any significant difference in efficacy and bleeding rate comparing to UFH.
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Lu, Yang, Ruiyang Zhang, Hulong Lei, Yiqiong Hang, Huiqin Xue, Xuan Cai, and Yonghong Lu. "Supplementation with Fermented Feedstuff Enhances Orexin Expression and Secretion Associated with Increased Feed Intake and Weight Gain in Weaned Pigs." Animals 12, no. 10 (May 23, 2022): 1329. http://dx.doi.org/10.3390/ani12101329.
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The health status of weaned pigs is crucial for their subsequent growth performance. Supplementation with fermented feedstuff is able to improve the feed intake and growth of weaned pigs; however, the exact mechanism behind this is not clear. Hence, in the present study a total of 320 Duroc × Landrace × Yorkshire weaned pigs were selected and allocated to the following two groups: unfermented diet group (UFD) and fermented diet group (FD). The experimental period lasted 21 days. At the end of the experiment, feces, blood, and gastrointestinal tissue samples (including the stomach, jejunum, and ileum) were collected and used for further analysis. The results of growth performance suggested that the FD group had significantly increased (p < 0.05) average daily feed intake (ADFI) and average daily gain (ADG) during the first week, during the last two weeks, and over the entire three-week period compared with the UFD group. The results of the apparent nutrient digestibility of pigs showed that, compared with the UFD group, the FD group showed increased phosphorus (p < 0.05) and CP (p < 0.1) digestibility. There were no significant differences in the serum biochemical parameters between the UFD and FD groups. Moreover, our results showed that the FD group showed significantly increased gene expression of SGLT1 and PepT1 in the jejunum (p < 0.05). Compared with the UFD group, the FD group showed an increased (p < 0.05) serum orexin level and prepro-orexin (PPOX) expression in the gastric fundus, jejunum, and ileum mucosa and increased IGF-1 and IGFR expression in the jejunum. Collectively, these results indicated that supplementation with fermented feedstuff in the diet effectively enhanced the feed intake and growth of weaned pigs and that this may have been caused by the increased orexin, IGF-1, and IGFR serum levels.
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Koppenhagen, Klaus, Alexander Tolle, Bettina Kemkes-Matthes, Michael Gräve, Frantisek Patek, Michael Drexler, Hans-Joachim Siemens, et al. "Fixed-dose, body weight-independent subcutaneous low molecular weight heparin Certoparin compared with adjusted-dose intravenous unfractionated heparin in patients with proximal deep venous thrombosis." Thrombosis and Haemostasis 90, no. 08 (2003): 252–59. http://dx.doi.org/10.1160/th02-09-0061.
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SummarySubcutaneous body weight-adjusted low molecular weight heparin (LMWH) has been proven as effective and safe as intravenous aPTT-adjusted unfractionated heparin (UFH) for the treatment of patients with acute deep venous thrombosis (DVT). In this study we evaluate the efficacy of the initial treatment of proximal DVT with a fixed-dose, body weight-independent application of the LMWH Certoparin with a six month follow-up.In a prospective, multicentre, randomized, active-controlled study 1220 patients with objectively diagnosed proximal DVT were randomly assigned to subcutaneous 8000 U anti-factor Xa of Certoparin twice daily for 10 to 14 days or intravenous aPTT-adjusted UFH for 5 to 8 days. Both regimen were followed by oral anticoagulation for 6 months. The primary end point was the rate of symptomatic and objectively confirmed thromboembolic events within 6 months. The aim of the study was to demonstrate the non-inferiority of the Certoparin regimen as compared to UFH.The per-protocol analysis revealed 22 (3.8%) thromboembolic events in the Certoparin group and 24 (4.3%) in patients assigned to UFH within 6 months, thereby proving the non-inferiority (p<0.01), confirmed by intent-to-treat analysis (p<0.001). Major bleeding occurred in 6 and 7 patients started on Certoparin or UFH during the treatment period. Thromboembolic events were equally distributed in body weight categories with < 50,50-80 and >80 kg as followed:0,3.6% and 4.1% of patients for the Certoparin group and 0, 4.6% and 4.2% of patients for the UFH group. The same was true for major bleeding complications with 0, 2.9% and 1.5% for Certoparin and 0, 3.5% and 4.2% for UFH. Overall mortality was 1.9 % in the Certoparin group and 2.7 % in the UFH group.Fixed-dose body weight-independent subcutaneous LMWH Certoparin is at least as efficacious and safe as intravenous aPTT-adjusted UFH for the initial treatment of acute proximal DVT. This effect is maintained during a 6-months follow-up of treatment with oral anticoagulation.
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Diaconu, Nadejda, Irina Civirjic, Galina Sorici, Aurel Grosu, Tatiana Cuzor, and Sabina Racila-Iatco. "Optional therapeutic management of intermediate-risk pulmonary embolism patients." Moldovan Medical Journal 66, no. 2 (December 2023): 56–65. http://dx.doi.org/10.52418/moldovan-med-j.66-2.23.09.
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Background: Few studies have evaluated the thrombolytic treatment in patients with intermediate-high risk pulmonary embolism, making this study more valuable. Material and methods: It was a prospective, non-randomized, open-label, single-center study. Eligible patients at the age of 18 or older with an acute pulmonary embolism (PE) confirmed by CT pulmonary angiography with onset until 14 day and signs of right ventricular (RV) overload on echocardiography took part in the study. Pulmonary Arterial CT Obstruction Index Rate (PACTOIR) was used to define the localization and the expansion zone of thromboembolism. This study included 18 patients with intermediate risk and acute submassive pulmonary thromboembolism. In thrombolysis (TT) group (n=9) were used 50 mg of tissue-plasminogen activator (t-PA) administered in infusion as 0.4 mg/h for 2 hours. In the standard anticoagulation group, unfractioned heparin (UFH) was administered as a bolus of 70 units/kg or a maximum of 5000 units, followed by continuous infusion at an initial rate of 16 units/kg or a maximum of 1000 units/h. Results: The mean age for TT group was 69 vs 63 for the UFH group. PACTOIR was 100% in 3 patients in the half-dose rt-PA group and in 2 patients in the UFH group. RV/LV diameter ratio decreased from baseline to 48 h post-procedure (1.55 vs. 1.13; mean difference, -0.42; p < 0.0001). Mean pulmonary artery systolic pressure was 55 mm Hg in both groups (p < 0.05), with 53 [43–60] in TT group vs. 41.5 [37–45] mmHg in UFH group, P<0.05. Also, RV/ LV ratio and systolic PAP decreased significantly in both groups. Severe bleeding with a need in red blood cell transfusion was seen in 0.11% (1 patient) in the TT group vs 0 in UFH group. The hospitalization length of stay was significantly shorter in the TT group (3.8±1.8, p < 0.05). The rate of secondary endpoints was significantly higher in the UFH group with a high rate of pulmonary hypertension (0 vs. 19%, p=0.003). Conclusions: Half-dose thrombolytic therapy in patients diagnosed with submassive pulmonary embolism significantly reduced death and hemodynamic decompensation in the first 7 days compared to anticoagulant therapy only. With all that being said, it can be concluded that patients with high-intermediate risk PE could benefit from reduced-dose TT.
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Benali, Karim, Julien Verain, Nefissa Hammache, Charles Guenancia, Darren Hooks, Isabelle Magnin-Poull, Marie Toussaint-Hacquard, Christian de Chillou, and Jean-Marc Sellal. "Running after Activated Clotting Time Values in Patients Receiving Direct Oral Anticoagulants: A Potentially Dangerous Race. Results from a Prospective Study in Atrial Fibrillation Catheter Ablation Procedures." Journal of Clinical Medicine 10, no. 18 (September 18, 2021): 4240. http://dx.doi.org/10.3390/jcm10184240.
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Background: Activated Clotting Time (ACT) guided heparinization is the gold standard for titrating unfractionated heparin (UFH) administration during atrial fibrillation (AF) ablation procedures. The current ACT target (300 s) is based on studies in patients receiving a vitamin K antagonist (VKA). Several studies have shown that in patients receiving Direct Oral Anticoagulants (DOACs), the correlation between ACT values and UFH delivered dose is weak. Objective: To assess the relationship between ACT and real heparin anticoagulant effect measured by anti-Xa activity in patients receiving different anticoagulant treatments. Methods: Patients referred for AF catheter ablation in our centre were prospectively included depending on their anticoagulant type. Results: 113 patients were included, receiving rivaroxaban (n = 30), apixaban (n = 30), dabigatran (n = 30), and VKA (n = 23). To meet target ACT, a higher UFH dose was required in DOAC than VKA patients (14,077.8 IU vs. 9565.2 IU, p < 0.001), leading to a longer time to achieve target ACT (46.5 min vs. 27.3 min, p = 0.001). The correlation of ACT and anti-Xa activity was tighter in the VKA group (Spearman correlation ρ = 0.53), compared to the DOAC group (ρ = 0.19). Despite lower ACT values in the DOAC group, this group demonstrated a higher mean anti-Xa activity compared to the VKA group (1.56 ± 0.39 vs. 1.14 ± 0.36; p = 0.002). Conclusion: Use of a conventional ACT threshold at 300 s during AF ablation procedures leads to a significant increase in UFH administration in patients treated with DOACs. This increase corresponds more likely to an overdosing than a real increase in UFH requirement.
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Hammerstingl, Christoph, Harald Schmidt, Giso von der Recke, Wilhelm Paar, Berndt Lüderitz, and Heyder Omran. "A prospective and randomized comparison of the safety and effects of therapeutic levels of enoxaparin versus unfractionated heparin in chronically anticoagulated patients undergoing elective cardiac catheterization." Thrombosis and Haemostasis 90, no. 08 (2003): 267–71. http://dx.doi.org/10.1160/th02-10-0159.
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SummaryConsecutive patients with atrial fibrillation and/or prosthetic heart valves, receiving chronic anticoagulation with phenprocoumon and scheduled to undergo cardiac catheterization, were randomized to subcutaneous enoxaparin twice daily (n = 32) or intravenous UFH (n = 36). Cardiac catheterization was performed at an international normalized ratio <1.5. Activated partial thromboplastin times and levels of anti-Factor Xa activity were measured daily. The time until effective anticoagulation (primary endpoint) was significantly shorter for enoxaparin than for UFH (1.1 ± 0.4 days versus 3.7 ± 2.5 days, p <0.0001). The percentage of days of effective anticoagulation was significantly higher in the enoxaparin group than in the UFH group (93.3 ± 9.5% versus 53.7 ± 26.6%, p <0.0001). In conclusion, enoxaparin achieves therapeutic levels of anticoagulation more rapidly and consistently than UFH in chronically anticoagulated patients with prosthetic heart valves and/or atrial fibrillation undergoing cardiac catheterization.
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Smith, Simon E. T., Jaclyn Jensen, Joel Roediger, Federico Sestito, Christian R. Hayes, Alan W. McConnachie, Jean-Charles Cuillandre, et al. "Discovery of a New Local Group Dwarf Galaxy Candidate in UNIONS: Boötes V." Astronomical Journal 166, no. 2 (July 28, 2023): 76. http://dx.doi.org/10.3847/1538-3881/acdd77.
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Abstract We present the discovery of Boötes V, a new ultra-faint dwarf galaxy (UFD) candidate. This satellite is detected as a resolved overdensity of stars during an ongoing search for new Local Group dwarf galaxy candidates in the UNIONS photometric data set. It has a physical half-light radius of 26.9 − 5.4 + 7.5 pc, a V-band magnitude of −4.5 ± 0.4 mag, and resides at a heliocentric distance of approximately 100 kpc. We use Gaia DR3 astrometry to identify member stars, characterize the systemic proper motion, and confirm the reality of this faint stellar system. The brightest star in this system was followed up using Gemini GMOS-N long-slit spectroscopy and is measured to have a metallicity of [Fe/H] = −2.85 ± 0.10 dex and a heliocentric radial velocity of v r = 5.1 ± 13.4 km s−1. Boötes V is larger (in terms of scale radius), more distant, and more metal-poor than the vast majority of globular clusters. It is likely that Boötes V is an UFD, though future spectroscopic studies will be necessary to definitively classify this object.
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Ismagilov, Ruslan R., Fanil S. Bilalov, and Marat A. Sharafutdinov. "The Bashkir state medical university, Ufa, Russian Federation." RUDN Journal of Medicine 27, no. 3 (December 15, 2023): 354–67. http://dx.doi.org/10.22363/2313-0245-2023-27-3-354-367.
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The study of patient satisfaction with the conditions of medical care in «COVID» hospitals, which were mainly repurposed from specialized medical organizations within the shortest time, is of particular relevance. The purpose of the study was an assessment of satisfaction with the conditions of medical care for patients with a new coronavirus infection. Materials and Methods. The study was conducted by questionnaire. The questionnaire was developed by the authors included 29 questions. The questionnaire consisted of 3 groups of questions: the first group was related to the socio-demographic characteristics of the respondents (gender, age, marital status, education, etc.); in the second group, respondents assessed their health status at the time of the survey; in the third group - respondents answered questions regarding satisfaction with the conditions of care and the need for additional care. The results of a survey of 341 patients diagnosed with U07.1 Coronavirus infection COVID-19 included in the study were divided into 2 groups: 1 group - patients treated in outpatient care (173; 50,9 %); group 2 - patients of « COVID « hospitals (167; 49,1 %). The total number of examined men was 20.8 %, women - 79.2 %. The median age was 43,2 ± 12,1 years. Most of the women were persons aged 40-49 years (38.2 %), among men - aged 50-59 years (43.7 %). Results and Discussion. At the time of the survey, patients of the «covid» hospital rated their health on average by 3,58±0,11 points, and patients who applied to the clinic by 3,72±0,09 (p 0.05) points. The level of availability of diagnostic studies, free drug provision and the attitude of doctors, patients of the clinic rated slightly lower. On the contrary, patients of the clinic rated the conditions of stay in the medical organization higher than patients of the «covid» hospital. After suffering from COVID-19, the interviewed patients noted the need for additional assistance. The most frequent of them were: spa treatment - 39.3 %; additional diagnostic care (examination) - 15.0 %; preventive care (professional examinations) - 15.0 %. Conclusion. A sociological survey made it possible to establish and compare the level of satisfaction with the provision of medical care for patients with a new coronavirus infection in medical and preventive institutions. It is important to further monitor patients’ opinions on their satisfaction with the organization of medical care and identify needs that can serve as the basis for planning, providing and maintaining the quality of services during the COVID-19 pandemic and other emergencies.
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Horbach, T., H. Wolf, H. C. Michaells, W. Wagner, A. Hoffmann, A. Schmidt, and H. Beck. "A Fixed-Dose Combination of Low Molecular Weight Heparin with Dihydroergotamine versus Adjusted-Dose Unfractionated Heparin in the Prevention of Deep-Vein Thrombosis after Total Hip Replacement." Thrombosis and Haemostasis 75, no. 02 (1996): 246–50. http://dx.doi.org/10.1055/s-0038-1650253.
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SummaryThe low dose heparin regimen (LDH) is not appropriate for prevention of intra- and postoperative thromboembolic complications in high risk patients, especially those undergoing elective hip replacement. Despite LDH prophylaxis, the incidence of deep-vein thrombosis (DVT) remains in a range of 20 to 35%. Adjusted-dose unfractionated heparin prophylaxis is thought to be one of the most effective regimens for thrombosis prophylaxis in this indication, but it requires two or three daily injections as well as precise monitoring of the activated partial thromboplastin time (aPTT). As an attractive alternative, we investigated the efficacy and safety of the low molecular weight heparin (LMWH) certoparin combined with dihydroergotamine (DHE) given once daily.In a randomised, open clinical trial, a total number of 305 patients undergoing total elective hip replacement were enrolled and divided into two groups, either receiving a fixed-dose combination of LMWH (3,000 IU) and DHE (0.5 mg) subcutaneously once daily, or adjusted-dose unfractionated heparin (UFH) subcutaneously every 8 h. The UFH dosage was adjusted daily to keep an aPTT of about 50 s. The aPTT was determined 3 h after the morning injection. During the study, the starting dose (15,000 IU/day) was increased to a plateau value of 28,800 ± 7,150 IU/day (mean ± SD) to maintain the aPTT in the prescribed range. The plateau value was achieved after 8 postoperative days. For analysis of efficacy 289 patients were evaluable. The occurrence of deep vein thrombosis was determined by bilateral ascending venography, which was performed on the same day in patients with clinical signs suggesting DVT; and in all remaining patients at the end of the prophylaxis period. Deep vein thrombosis was diagnosed in 17 of 142 patients (12.0%) treated with LMWH/DHE and in 13 of 147 patients (8.8%) treated with adjusted-dose UFH. Combined distal-proximal thrombosis was more frequently in patients receiving UFH (n = 5; 3.4%) compared to the LMWH/DHE group (n = 2; 1.4%). These differences are statistically not significant. In the UFH group one case of non-fatal pulmonary embolism occurred. Both prophylaxis regimens were well tolerated; wound bleeding was observed in 8 (5.3%) patients in the LMWH group and in 6 (4.0%) patients in the UFH group. Intraoperative blood-loss volume (mean±SD) was 751 ± 339 ml (LMWH/DHE) and 736 ± 380 ml (UFH), whereas postoperative drain-loss volume (mean ± SD) was found to be 523 ± 333 ml (LMWH/DHE) and 581 ± 404 ml (UFH). Whole blood transfusion volumes (mean ± SD) were 570 ± 202 ml (LMWH/DHE) and 748 ± 455 ml (UFH). Additionally, red cell replacement volumes (mean ± SD) were 804 ± 435 ml (LMWH/DHE) and 720 ± 328 ml (UHF). Revision of wound or additional drainage were necessary in 3 LMWH/DHE and 7 UFH patients. One patient needed reoperation due to bleeding, 3 (2.0%) had petechia and 1 exhibited an allergic exanthema, all of them in the UFH group. A slight erythema at the injection site was observed in 6 (3.9%) patients receiving LMWH/DHE. During the course of prophylaxis, injection hematomas were documented in 57.9% (LMWH/DHE) and in 61.4% (UFH) of the patients. All differences were statistically not significant.Single daily subcutaneous injections of LMWH/DHE appeared to be safe and efficacious compared to adjusted-dose UFH for prophylaxis of DVT in high-risk patients.
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Gazder, Tanzeel Ur Rahman, Kanwal Naz, Vikram Seetlani, Syed Rabiullah, Usman Qamar, Mazahir Zulfiqar, Hamza Akhter, Saeed Abdi, and Manzoor Hussain. "To assess the impact of prior urethral dilatation or DVIU on the outcome of anterior urethroplasty." International Journal of Endorsing Health Science Research (IJEHSR) 11, no. 3 (August 24, 2023): 129–35. http://dx.doi.org/10.29052/ijehsr.v11.i3.2023.129-135.
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Background: Male urethral stricture has remained the major problem in urologic practice. Patients presenting with urethral stricture disease are commonly managed by dilatation, DVIU, and urethroplasty.
Methodology: This is a descriptive study of male patients who underwent anterior urethroplasty at our setup from 5th August 2021 to 25th February 2022. We analyzed the age, duration, type, length, and location of the stricture and the surgical treatment outcome after urethroplasty. The post-operative catheter was removed after 3 weeks, and UFM is advised. Qmax (max flow rate) > 15 ml/sec was measured on UFM (uroflowmetry) on the 1st week, 6 weeks, and followed on 3 months. Final outcome in terms of success was assessed by uroflowmetry. A maximum urine flow greater than 15mL/s after 3 months’ treatment assessed by uroflowmetry was considered as success.
Results: In our study, the blood loss in group A and group B patients, those patients who had DVIU or dilation in the past, had more bleeding during surgery than those who did not have a history of surgery. 66.67% of group B patients have bleeding from 200 ml to 500 ml, which is higher than group A patients. In our study, we found that if the patient had undergone surgery or no surgery had taken place before urethroplasty, the results in terms of UFM were quite similar, as in group A, 96.69% of patients had UFM more than 15 ml/sec, and in group B 87.88% had UFM more than 15 ml/sec.
Conclusion: Urethral dilatation or DVIU delays definitive treatment and increases operative challenges by increasing the length of stricture, more adhesion, and more fibrosis but has minimal impact on the outcome of urethroplasty success.
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Moll, Stephan, Charles S. Abrams, Lawrence Rice, Richard C. Becker, Peter B. Berger, Kevin J. Anstrom, Emily F. Honeycutt, et al. "Thrombocytopenia Is More Common and Nadir Occurs Earlier with Unfractionated Heparin Than with Low Molecular Weight Heparin - Results from the Prospective Catch Registry." Blood 104, no. 11 (November 16, 2004): 2197. http://dx.doi.org/10.1182/blood.v104.11.2197.2197.
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Abstract Background : Thrombocytopenia in the patient on heparin can have various etiologies, including benign reversible causes and serious, potentially life-threatening ones, such as heparin induced thrombocytopenia (HIT). Knowledge about the prevalence of and timecourse of thrombocytopenia in heparin-treated patients may be helpful to develop systems of alerting clinicians to possible HIT and determining how frequently to check blood counts to detect thrombocytopenia that may be heralding HIT. Methods : The CATCH registry is a prospective registry of inpatients enrolled between March 2003 and April 2004 at over 50 US hospitals in 3 strata: [1] receiving > 96 hours of unfractionated heparin (UFH) or low molecular weight heparin (LMWH), [2] developing thrombocytopenia (platelets >50% reduction from baseline or <150,000/mm3) in the cardiac care unit and [3] patients on whom HIT tests were ordered. Here we present the data of the prolonged heparin stratum. Results : 1,121 and 861 patients received UFH and LMWH, respectively, for > 96 hours. A platelet count decrease of > 50 % from baseline was seen more frequently in patients on UFH than in patients on LMWH (10.7% and 7.9 %, respectively; p = 0.03). The parameters that predicted development of thrombocytopenia in the UHF group were length of heparin therapy, body mass index, and admission to a cardiac service; the only parameter predicting thrombocytopenia in the LMWH group was length of LMWH treatment. Of the patients with decreased platelet count by > 50 % from baseline (for UFH n = 120; for LMWH n = 68), this drop occurred in the UFH group at a median of 3.0 days after initiation of heparin and at a median of 4.0 days in the LMWH group. The difference in timing between the 2 groups was not statistically significant (p = 0.205). The platelet nadir was reached after a median /mean of 4.0 / 7.4 days in the UFH group, and 8.0 / 11.4 days in the LMWH group. This was statistically significantly different between the 2 groups (p-value = 0.0025). Conclusions : A platelet count decrease of > 50 % from baseline occurs frequently in inpatients treated with prolonged heparin. It occurs slightly more frequently on UFH than on LMWH. The median time to onset of thrombocytopenia (> 50 % decrease from baseline) occurs early, at 3–4 days. Daily platelet count checks in the first few days of heparin therapy may be helpful to rapidly discover thrombocytopenia that may then prompt HIT testing.
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Fiessinger, J. N., M. Lopez-Fernandez, E. Gatterer, S. Granqvist, A. Kher, C. G. Olsson, and K. Söderberg. "Once-daily Subcutaneous Dalteparin, a Low Molecular Weight Heparin, for the Initial Treatment of Acute Deep Vein Thrombosis." Thrombosis and Haemostasis 76, no. 02 (1996): 195–99. http://dx.doi.org/10.1055/s-0038-1650553.
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SummaryThe aim of the study was to compare the efficacy and safety of once-daily subcutaneous injection of dalteparin, a low molecular weight heparin, with that of intravenous unfractionated heparin in the treatment of deep venous thrombosis (DVT). Patients were included if they had deep venous thrombosis distal to inguinal ligament and were randomised either before, if it was considered necessary, or after phlebographic verification of the diagnosis. There was no pre-inclusion treatment with unfractionated heparin. One hundred and twenty patients received dalteparin, administered subcutaneously once-daily at a fixed dose of 200 IU anti-factor Xa/kg, and 133 patients received a continuous intravenous infusion of unfractionated heparin (UFH). Oral anticoagulation was started on the first or second day, and initial treatment with dalteparin or UFH discontinued when the prothrombin time was in the therapeutic range (2<INR<3) on two consecutive days. Control phlebograms were taken within 4 days, thereafter. There were no significant differences between the two initial treatment groups in improvements in Marder score. Two major bleeding events occurred in the UFH group versus none in the dalteparin group. One patient in each group experienced clinically significant pulmonary embolism. During a mean follow-up period of 6.9 ± 1.5 months, recurrent DVT occurred in four patients in the dalteparin group and in two of the UFH group. These results confirm those of a previous study on dalteparin in the initial treatment of DVT, and suggest that dalteparin administered once-daily at a fixed dose of 200 UI/kg is as effective and well-tolerated as UFH in patients with DVT below the inguinal ligament. The present study also demonstrates that dalteparin can be started as soon as the diagnosis of DVT is suspected and without pre-treatment with UFH. Given that the administration of once-daily subcutaneous injections needs not require a patient to be hospitalised, studies to investigate the possibility of using dalteparin for the initial treatment of DVT in the outpatient setting are warranted.
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Selgas, Rafael, M. Auxiliadora Bajo, M. José Castro, Gloria Del Peso, Abelardo Aguilera, Antonio Fernández-Perpén, Antonio Cirugeda, and José A. Sánchez-Tomero. "Risk Factors Responsible for Ultrafiltration Failure in Early Stages of Peritoneal Dialysis." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 20, no. 6 (November 2000): 631–36. http://dx.doi.org/10.1177/089686080002000609.
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Objective To define risk factors for ultrafiltration failure (UFF) during early stages of peritoneal dialysis (PD). Design Retrospective analysis of a group of patients whose peritoneal function was prospectively followed. Setting A tertiary-care public university hospital. Patients Nineteen of 90 long-term PD patients required a peritoneal resting period to recover UF capacity: 8 had this requirement before the third year on PD (early, EUFF group) and 11 had a late requirement (LUFF group). The remaining 71 patients, those with stable peritoneal function over time, constituted the control group. Main Outcome Measures Peritoneal UF capacity under standard conditions (monthly) and small solute peritoneal transport (yearly). Results None of the conditions appearing at the start of PD or during the observation period could be definitely identified as the cause of UFF. There were no differences in characteristics between the EUFF group and the other two groups, except for the higher prevalence of diabetes in the EUFF group. Residual renal function (RRF) declined in all three groups during the first 2 years, with rapid loss during the third year in the EUFF group. This rapid loss in RRF was coincident with UFF. Peritoneal solute and water transport at baseline was similar in the three groups. After 2 years on PD, individuals in the EUFF group showed a significantly lower UF and higher creatinine mass transfer coefficient values than those in the LUFF group. Diabetic patients in the control group showed remarkable stability in UF capacity over time. During the second year on PD, requirement for increases in dialysate glucose concentration was 3.4 ± 0.5% in the LUFF group, but as high as 25.5 ± 24.2% in the EUFF group. The accumulated days of active peritonitis (APID, days with cloudy effluent) were similar for the three groups after 1, 2, and 3 years on PD. Interestingly, diabetic patients in the control group showed an APID index significantly lower than the overall EUFF group. Diabetics in the control group also had significantly lower APID versus nondiabetics in the control group ( p = 0.016). Conclusions Our findings suggest that certain patients develop early UFF type I. Diabetic state and a higher glucose requirement to obtain adequate UF suggest that glucose on both sides of the peritoneal membrane could be responsible. The mechanisms for this higher requirement remain to be elucidated. The identification of a larger cohort of these early UFF patients should lead to a better exploration of the primary pathogenic mechanisms.
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Zhang, Yizhi, Zhiguo Zou, Bihe Xu, Binghua Chen, Heng Ge, Song Ding, and Jun Pu. "Impact of Bivalirudin on Ischemia/Reperfusion Injury in Patients with Reperfused STEMI Assessed by Cardiac Magnetic Resonance." Pharmaceuticals 17, no. 2 (February 1, 2024): 196. http://dx.doi.org/10.3390/ph17020196.
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Thrombin is an important ischemia/reperfusion injury (IRI) mediator in patients with ST-elevation myocardial infarction (STEMI). This study examines the use of bivalirudin, a direct thrombin inhibitor, in reducing IRI in STEMI patients. STEMI patients (n = 21) were treated with bivalirudin and compared to 21 patients treated with unfractionated heparin (UFH) from the EARLY Assessment of Myocardial Tissue Characteristics by CMR in STEMI (EARLY-MYO-CMR) registry (NCT03768453). Infarct size (IS) and left ventricular ejection fraction (LVEF) were comparable between the two groups at follow up. During the first cardiac magnetic resonance (CMR) scan within the first week after percutaneous coronary intervention (PCI), all patients in both the bivalirudin and UFH groups exhibited myocardial edema. However, the myocardium edema volume was significantly less in the bivalirudin group (p < 0.05). At the one-month follow-up, a smaller proportion of patients in the bivalirudin group than in the UFH group exhibited myocardial edema (4.7% vs. 33.3%, p < 0.05). At the three-month follow-up, myocardial edema had completely resolved in the bivalirudin group, while it persisted in two patients in the UFH group. The incidence and volume of microvascular obstruction (MVO) were significantly lower in the bivalirudin group during the acute phase. Additionally, the incidence of intramyocardial hemorrhage (IMH) was significantly lower in the bivalirudin group during both the acute and follow up (p < 0.05). These findings were corroborated by T2 and T1 mapping results. The study concluded that the use of bivalirudin for anticoagulation is associated with attenuated IRI in STEMI patients who receive primary PCI.
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Muhd Rodhi, Miradatul Najwa, Puteri Nur Syareena Saifuddin, and Harumi Veny. "Characterisation of used cooking oil (UCO) and orange peels as the medium of insect repellent." Malaysian Journal of Chemical Engineering and Technology (MJCET) 3, no. 2 (December 31, 2020): 66. http://dx.doi.org/10.24191/mjcet.v3i2.10947.
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Used cooking oil (UCO) is abundant waste oil in Malaysia, due to its daily use in frying food. The proper way to dispose UCO is yet to be found and creating awareness among Malaysians on disposing and recycling UCO required a long period of time. Therefore, alternative needs to be taken to solve this issue by transforming UCO into a value-added product such as insect repellent. Thus, the objective of this research is to investigate the presence of active functional chemical compounds in UCO and orange (Citrus sinensis) peels powder (limonene) that would help to transform UCO into a repellent. Based on GC-MS analysis, there was presence of fatty acids in UCO such as palmitic acid (C16:0), stearic acid (C18:0), oleic acid (C18:1), myristic acid (C14:0) and capric acid (C10:0). FTIR analysis has proven that orange (Citrus sinensis) peels powder contained limonene compound due to presence of alkene (C=C) group. The results of UCO and orange peels analysis, as well as comparison made with previous studies show that UCO and orange peels powder are potential to be the medium of insect repellent.