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Author: Grafiati
Published: 10 December 2022
Last updated: 28 January 2023

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1

MacLachlan, Jordan, Yi Mei, Juergen Branke, and Mengjie Zhang. "Genetic Programming Hyper-Heuristics with Vehicle Collaboration for Uncertain Capacitated Arc Routing Problems." Evolutionary Computation 28, no. 4 (December 2020): 563–93. http://dx.doi.org/10.1162/evco_a_00267.

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Due to its direct relevance to post-disaster operations, meter reading and civil refuse collection, the Uncertain Capacitated Arc Routing Problem (UCARP) is an important optimisation problem. Stochastic models are critical to study as they more accurately represent the real world than their deterministic counterparts. Although there have been extensive studies in solving routing problems under uncertainty, very few have considered UCARP, and none consider collaboration between vehicles to handle the negative effects of uncertainty. This article proposes a novel Solution Construction Procedure (SCP) that generates solutions to UCARP within a collaborative, multi-vehicle framework. It consists of two types of collaborative activities: one when a vehicle unexpectedly expends capacity ( route failure), and the other during the refill process. Then, we propose a Genetic Programming Hyper-Heuristic (GPHH) algorithm to evolve the routing policy used within the collaborative framework. The experimental studies show that the new heuristic with vehicle collaboration and GP-evolved routing policy significantly outperforms the compared state-of-the-art algorithms on commonly studied test problems. This is shown to be especially true on instances with larger numbers of tasks and vehicles. This clearly shows the advantage of vehicle collaboration in handling the uncertain environment, and the effectiveness of the newly proposed algorithm.
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2

Koristka, Stefanie, Marc Cartellieri, Anja Feldmann, Claudia Arndt, Simon Loff, Irene Michalk, Roberta Aliperta, et al. "Flexible Antigen-Specific Redirection of Human Regulatory T Cells Via a Novel Universal Chimeric Antigen Receptor System." Blood 124, no. 21 (December 6, 2014): 3494. http://dx.doi.org/10.1182/blood.v124.21.3494.3494.

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Abstract Based on compelling evidence from a vast number of in vitro and in vivostudies, Tregs have become an attractive cell population to treat or even prevent auto- and alloimmunity including Graft-versus-Host disease (GvHD). However, several safety concerns still exist as for example the risk of global immunosuppression using polyclonal Tregs. In fact, experiments in mice showed that adoptive transfer or induction of antigen-specific Tregs is more potent regarding suppression of pathogenic immune responses when compared to polyclonal Treg populations. Unfortunately, the isolation and expansion of naturally occurring antigen-specific Tregs is technically difficult, labour-intensive, and time-consuming. An attractive way to overcome these limitations and to endow polyclonal Treg populations with a desired antigen-specificity is their engraftment with chimeric antigen receptors (CARs). In this context, CAR-modification represents a promising approach to redirect polyclonal Tregs in an antigen-specific manner to suppress ongoing self-destructive immune responses at the site of inflammation. Nevertheless, until now redirection of CAR-engineered T cells is limited to a single target antigen, restricting this approach to an unflexible monospecific therapy. Therefore, we developed a more flexible universal CAR (UCAR) platform that allows redirection of T cells to an in principal unrestricted number of surface antigens. T cells are engrafted with UCARs that bind to a small peptide epitope derived from a human nuclear protein. Cross-linkage to target cells is mediated by independent target modules that provide antigen-specificity and comprise the peptide epitope recognized by the UCAR. In order to target different tissue antigens, the target modules can easily be exchanged. Thereby, once established, the treatment strategy can easily be applied to various auto- and alloimmune diseases. At present, the CD45RA+ population is the Treg subset of choice for a clinical application as these cells have the highest capacity to maintain phenotypic and functional Treg properties upon prolonged ex vivo expansion. Here we show that highly pure, sorted CD4+CD25+CD127lowCD45RA+ Tregs can be genetically manipulated using lentiviral gene transfer, resulting in approximately 70 % of UCAR-expressing Treg cells. The transduction procedure itself did not affect the phenotype of UCAR-engineered Tregs as it was similar to non-transduced wildtype cells. Both Treg populations presevered FOXP3 expression even after prolonged in vitro cultivation (> 95 % FOXP3+). Upon incubation with antigen-positive target cells and a respective target module UCAR-engineered Tregs upregulate the activation markers CD69 and LAP demonstrating that the cells can be restimulated antigen-specifically. Most importantly, UCAR-engrafted Tregs were functionally activated upon antigen encounter, demonstrated by suppression of proliferation and expansion of cocultured autologous T effector cells. Taken together, our results pave the way towards an application of UCAR technology for a site-specific recruitment of CAR-modified Tregs into inflamed tissues aiming at re-establishing immune homeostasis. Due to its high flexibility UCAR-engrafted Tregs can easily and universally be used for treatment of various autoimmune diseases or GvHD just by exchanging the tissue-specific target modules. Disclosures Cartellieri: Cellex Patient Treatment GmbH: Employment. Ehninger:GEMoaB GmbH: Employment, Patents & Royalties. Ehninger:GEMoaB GmbH: Consultancy, Patents & Royalties. Bachmann:GEMoaB GmbH: Consultancy, Patents & Royalties.
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3

Capdeville, Mariola Grez, and Tom D. Crenshaw. "65 Evaluation of Calcium to Phosphorus Ratio in Spot Urine Samples as a Practical Method to Monitor Phosphorus Intake Adequacy in Sows." Journal of Animal Science 99, Supplement_1 (May 1, 2021): 41. http://dx.doi.org/10.1093/jas/skab054.072.

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Abstract The reliability of spot urinary Ca to P ratio (uCa:P) to assess P intake adequacy in sows was evaluated. Thirty-six multiparous sows were fed one of six concentrations of dietary total P (0.40, 0.48, 0.56, 0.64, 0.72, and 0.80%), with a constant Ca to total P ratio (1.25:1), from day 7.5+1 after breeding until the end of lactation (day 26.6+1). Total 24-hour urine samples were collected in mid (day 77.1+2) and late gestation (day 112.4+1), and early (day 4.5+1 and late (day 18.2+1) lactation. In parallel to 24-hour collections, spot urine samples were collected at three times (early morning, late morning, and late afternoon) in late gestation and late lactation. Urine Ca and P concentrations were measured and uCa:P was calculated. Sows were classified as P-adequate or P-deficient according to dietary P intake. Sows fed P-deficient diets had greater uCa:P than sows fed P-adequate diets (P < 0.001). Receiver operator characteristic (ROC) curves were used to determine cut-off values for uCa:P to predict P intake adequacy. The area under the ROC for uCa:P was 0.88 (95% CI 0.81–0.95). Best cut-off value of uCa:P was 1.5 (sensitivity 94% and specificity 68%) to identify sows fed P-deficient diets, and 0.5 for P-excessive diets (sensitivity 82% and specificity 82%). A strong relationship between uCa:P in 24-hour and spot urine samples was determined (r = 0.93, P < 0.01), independent of physiological state and collection time of spot samples (adjusted-R2 = 0.86, P < 0.01). The degree of agreement between spot and 24-hour urine for P intake adequacy, assessed by Cohen’s weighted kappa analysis, was substantial (0.78, 95% CI 0.69–0.88). Measurements of uCa:P in spot urine samples provide a reliable prediction of the adequacy of P intake in reproducing sows. Values of uCa:P > 1.5 were associated with P-deficient diets, whereas uCa:P < 0.5 reflected excessive P intake.
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4

Sano, Tomoyasu, Ryohei Hattori, Shin Yamada, Osamu Kamihira, Hiroaki Kobayashi, Yoshikazu Tsuji, Naoto Sassa, Momokazu Gotoh, and Toyonori Tsuzuki. "Proposal of a new subcategory of the pT3 classification: Effects of tumor location and subclassification of renal pelvic pT3 to predict the prognosis of pelvic carcinoma more accurately than the current TNM classification." Journal of Clinical Oncology 38, no. 6_suppl (February 20, 2020): 455. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.455.

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455 Background: Whether pT3 urothelial carcinoma of the renal pelvis (UCRP) and urothelial carcinoma of the ureter (UCU) show the same prognosis or not remains controversial.This study aims to reveal whether the prognosis of pT3 UCRP shows similar to those of pT3 UCU. Methods: We retrospectively evaluated 954 patients who underwent nephroureterectomy between 1983 and 2017 at our institutions.None of the patients received neoadjuvant therapy.All HE slides for each patient were reviewed by a single genitourinary pathologist (TT).pT3 UCRP was subdivided pT3a (urothelial carcinomas that extend only to the renal medulla) and pT3b (urothelial carcinomas that extend to the renal cortex and/or peripelvic adipose tissue) according to the criteria previously we proposed.Fine and Gray model was developed to predict the reccurence-free survival (RFS) and cancer-specific survival (CSS). Results: Overall, 954 patients were eligible for this study, 493 of whom were pT3 with only renal pelvis and 461 of whom were pT3 with only ureter. A total of 202 cases were pT3 UCRP and 146 were pT3 UCU. The pT3 subclassification of UCRP resulted in 79 pT3a and 120 pT3b cases.No significant difference was found in the 5-yr RFS and 5-yr CSS between pT3a UCRP and pT2 UCRP and pT2 UCU. (RFS; pT3a UCRP vs pT2 UCRP: HR = 1.19 p = 0.74; pT3a UCRP vs pT2 UCU HR = 0.88, p = 0.72, CSS;pT3a UCRP vs. pT2 UCRP: HR = 0.69; p = 0.56; pT3a UCRP vs. pT2 UCU: HR = 0.66, p = 0.31) The RFS rate was significantly higher in the pT3a UCRP than that of pT3b, (pT3a vs pT3b: HR = 2.59, p = 0.0038) and so was the CSS rate. (pT3a vs. pT3b: HR = 3.1 p = 0.001) In fine and gray model analysis for RFS, pT stage, lymph node metastasis, WHO/ISUP grade, lymphovascular invasion were independently associated with tumor recurrence, whereas pT stage, lymph node metastasis, operation method, histologic type, lymphovascular invasion, gross type, adjuvant chemotherapy were independently associated with cancer mortality. Conclusions: Subclassifying pT3 UCRP into pT3a and pT3b was useful in determining the prognosis of different patients.The pT3b UCRP showed similar outcome compared to those of UCU.
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5

Viegas, Carla S. B., Marjolein Herfs, Marta S. Rafael, José L. Enriquez, Alexandra Teixeira, Inês M. Luís, Cynthia M. R. van ‘t Hoofd, et al. "Gla-Rich Protein Is a Potential New Vitamin K Target in Cancer: Evidences for a Direct GRP-Mineral Interaction." BioMed Research International 2014 (2014): 1–14. http://dx.doi.org/10.1155/2014/340216.

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Gla-rich protein (GRP) was described in sturgeon as a new vitamin-K-dependent protein (VKDP) with a high density of Gla residues and associated with ectopic calcifications in humans. Although VKDPs function has been related withγ-carboxylation, the Gla status of GRP in humans is still unknown. Here, we investigated the expression of recently identified GRP spliced transcripts, theγ-carboxylation status, and its association with ectopic calcifications, in skin basal cell and breast carcinomas. GRP-F1 was identified as the predominant splice variant expressed in healthy and cancer tissues. Patterns ofγ-carboxylated GRP (cGRP)/undercarboxylated GRP (ucGRP) accumulation in healthy and cancer tissues were determined by immunohistochemistry, using newly developed conformation-specific antibodies. Both GRP protein forms were found colocalized in healthy tissues, while ucGRP was the predominant form associated with tumor cells. Both cGRP and ucGRP found at sites of microcalcifications were shown to havein vitrocalcium mineral-binding capacity. The decreased levels of cGRP and predominance of ucGRP in tumor cells suggest that GRP may represent a new target for the anticancer potential of vitamin K. Also, the direct interaction of cGRP and ucGRP with BCP crystals provides a possible mechanism explaining GRP association with pathological mineralization.
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6

Loeb, K. R., and A. L. Haas. "Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern." Molecular and Cellular Biology 14, no. 12 (December 1994): 8408–19. http://dx.doi.org/10.1128/mcb.14.12.8408-8419.1994.

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Ubiquitin cross-reactive protein (UCRP), a 15-kDa interferon-induced protein, is a sequence homolog of ubiquitin that is covalently ligated to intracellular proteins in a parallel enzymatic reaction and is found at low levels within cultured cell lines and human tissues not exposed to interferon. Ubiquitin and UCRP ligation reactions apparently target distinct subsets of intracellular proteins, as judged from differences in the distributions of the respective adducts revealed on immunoblots. In this study, successive passages of the human lung carcinoma line A549 in the presence of neutralizing antibodies against alpha and beta interferons had no effect on the levels of either free or conjugated UCRP, indicating that these UCRP pools are constitutively present within uninduced cells and are thus not a consequence of autoinduction by low levels of secreted alpha/beta interferon. In an effort to identify potential targets for UCRP conjugation, the immunocytochemical distribution of UCRP was examined by using affinity-purified polyclonal antibodies against recombinant polypeptide. UCRP distributes in a punctate cytoskeletal pattern that is resistant to extraction by nonionic detergents (e.g., Triton X-100) in both uninduced and interferon-treated A549 cells. The cytoskeletal pattern colocalizes with the intermediate filament network of epithelial and mesothelial cell lines. Immunoblots of parallel Triton X-100-insoluble cell extracts suggest that the cytoskeletal association largely results from the noncovalent association of UCRP conjugates with the intermediate filaments rather than direct ligation of the polypeptide to structural components of the filaments. A significant increase in the sequestration of UCRP adducts on intermediate filaments accompanies interferon induction. These results suggest that UCRP may serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments.
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7

Loeb, K. R., and A. L. Haas. "Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern." Molecular and Cellular Biology 14, no. 12 (December 1994): 8408–19. http://dx.doi.org/10.1128/mcb.14.12.8408.

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Ubiquitin cross-reactive protein (UCRP), a 15-kDa interferon-induced protein, is a sequence homolog of ubiquitin that is covalently ligated to intracellular proteins in a parallel enzymatic reaction and is found at low levels within cultured cell lines and human tissues not exposed to interferon. Ubiquitin and UCRP ligation reactions apparently target distinct subsets of intracellular proteins, as judged from differences in the distributions of the respective adducts revealed on immunoblots. In this study, successive passages of the human lung carcinoma line A549 in the presence of neutralizing antibodies against alpha and beta interferons had no effect on the levels of either free or conjugated UCRP, indicating that these UCRP pools are constitutively present within uninduced cells and are thus not a consequence of autoinduction by low levels of secreted alpha/beta interferon. In an effort to identify potential targets for UCRP conjugation, the immunocytochemical distribution of UCRP was examined by using affinity-purified polyclonal antibodies against recombinant polypeptide. UCRP distributes in a punctate cytoskeletal pattern that is resistant to extraction by nonionic detergents (e.g., Triton X-100) in both uninduced and interferon-treated A549 cells. The cytoskeletal pattern colocalizes with the intermediate filament network of epithelial and mesothelial cell lines. Immunoblots of parallel Triton X-100-insoluble cell extracts suggest that the cytoskeletal association largely results from the noncovalent association of UCRP conjugates with the intermediate filaments rather than direct ligation of the polypeptide to structural components of the filaments. A significant increase in the sequestration of UCRP adducts on intermediate filaments accompanies interferon induction. These results suggest that UCRP may serve as a trans-acting binding factor directing the association of ligated target proteins to intermediate filaments.
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8

Wang, Jiawei, Yunxiao Zhao, Fengque Zheng, Nana Ma, Rongyan Qin, Weili Qin, Bo Liu, and Aiping Qin. "Activated Human Umbilical Cord Blood Platelet-Rich Plasma Enhances the Beneficial Effects of Human Umbilical Cord Mesenchymal Stem Cells in Chemotherapy-Induced POF Rats." Stem Cells International 2021 (October 25, 2021): 1–23. http://dx.doi.org/10.1155/2021/8293699.

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Saving the ovarian function of premature ovarian failure (POF) patients undergoing chemotherapy is an important problem in the field of reproductive medicine. At present, human umbilical cord mesenchymal stem cells (HucMSCs) have been used in the treatment of POF, but the effect is still not optimal. The purpose of this study was to determine whether human umbilical cord blood platelet-rich plasma (ucPRP) enhances the beneficial effects of HucMSCs in the treatment of POF. First, we observed the effects of changes in the biological activity of ucPRP on HucMSCs in vitro. Subsequently, we tracked the distribution and function of the HucMSCs in POF rats, and the rats’ estrus cycle and serum sex hormones, follicular development, ovarian angiogenesis, ovarian granulosa cell proliferation, and apoptosis were assessed. The results of the study showed that the addition of ucPRP in vitro accelerates proliferation and reduces apoptosis of the HucMSCs while upregulating the stemness gene of the HucMSCs. The combined transplantation of HucMSCs and ucPRP resulted in more stem cells being retained in the ovaries of POF rats, the estrus cycle of the POF rats being restored, the levels of serum E2, AMH, and FSH improving, and damaged follicles beginning to grow. Finally, we confirmed that the potential mechanism of the combination of HucMSCs and ucPRP to rescue the ovarian function of POF rats is to promote ovarian angiogenesis and to promote the proliferation and reduce the apoptosis of ovarian granulosa cells. The upregulation of AMH and FHSR expression and the downregulation of caspase-3 expression in granulosa cells are potential mechanisms for the recovery of ovarian function. Our research results suggest that the combined application of HucMSCs and ucPRP is a safe and efficient transplantation program for the treatment of POF, thus providing a reliable experimental basis for the clinical application of stem cell therapy in POF.
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9

Galetto, Roman. "Cellules CAR-T allogéniques (UCART)." Bulletin de l'Académie Nationale de Médecine 202, no. 7 (September 2018): 1421–30. http://dx.doi.org/10.1016/s0001-4079(19)30208-0.

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10

Anonymous. "UCAR visitor research programs." Eos, Transactions American Geophysical Union 70, no. 13 (1989): 204. http://dx.doi.org/10.1029/eo070i013p00204-01.

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11

Иванов, Афанасий, and Afanasiy Ivanov. "COMBINING OF MATERIAL STRAIN PROCESSING METHODS." Bulletin of Bryansk state technical university 2019, no. 10 (November 7, 2019): 19–24. http://dx.doi.org/10.30987/article_5db95e85a4a413.79050731.

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The purpose of the work consists in the investigation of stress-strain properties and destruction mechanism of low-alloy steel 09G2S subjected to extrusion and uniformly channel angular pressing (UCAP). The combined method of Strain processing consists in the successive use of extrusion methods and UCAP. There is shown an example of low-alloy steel 09G2S strengthening with the use of extrusion and UCAP. There are presented data on stress-strain properties and destruction mechanism of steel 09G2S samples at uniaxial tension at the state of delivery and after strengthening. Strength increase and steel plasticity decrease is shown. On the basis of the results of fractal graphics analysis a viscous character of steel 09G2S destruction at the state of delivery and after extrusion and UCAP is defined.
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12

Fredsøe, Jacob, Anne K. I. Rasmussen, Emma B. Laursen, Yunpeng Cai, Kenneth A. Howard, Bodil G. Pedersen, Michael Borre, Peter Mouritzen, Torben Ørntoft, and Karina D. Sørensen. "Independent Validation of a Diagnostic Noninvasive 3-MicroRNA Ratio Model (uCaP) for Prostate Cancer in Cell-Free Urine." Clinical Chemistry 65, no. 4 (April 1, 2019): 540–48. http://dx.doi.org/10.1373/clinchem.2018.296681.

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Abstract BACKGROUND Detection of prostate cancer (PC) based on serum prostate-specific antigen (PSA) testing leads to many unnecessary prostate biopsies, overdiagnosis, and overtreatment of clinically insignificant tumors. Thus, novel and more accurate molecular biomarkers are required. METHODS Using reverse transcription quantitative PCR, we measured the concentrations of 45 preselected microRNAs (miRNAs) in extracellular vesicle-enriched cell-free urine samples from 4 independent patient cohorts from Spain and Denmark, including 758 patients with clinically localized PC, 289 noncancer controls with benign prostatic hyperplasia (BPH), and 233 patients undergoing initial transrectal ultrasound (TRUS)-guided prostate biopsy owing to PC suspicion (101 with benign and 132 with malignant outcome). Diagnostic potential was assessed by ROC and decision curve analysis. RESULTS We identified and successfully validated 8 upregulated and 21 downregulated miRNAs in urine from PC patients. Furthermore, we validated a previously identified 3-miRNA diagnostic ratio model, uCaP (miR-222–3p*miR-24–3p/miR-30c-5p). High uCaP scores were distinctive of PC in urine samples from BPH vs PC patients in 3 independent cohorts [area under the curve (AUC) = 0.84, 0.71, 0.72]. Additionally, uCaP predicted TRUS biopsy results with greater accuracy than PSA (AUC uCaP = 0.644; AUC PSA = 0.527) for patients within the diagnostic gray zone (PSA ≤ 10 ng/mL). CONCLUSIONS We successfully validated a urine-based diagnostic 3-miRNA signature for PC (uCaP) in 3 independent patient cohorts from 2 countries. In the future, the simple and noninvasive uCaP test may be used to help more accurately select patients for prostate biopsy. Prospective clinical validation is warranted.
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13

Anthes, Richard A., Otis B. Brown, Kelvin K. Droegemeier, and Jack D. Fellows. "UCAR and NCAR at 40." Bulletin of the American Meteorological Society 82, no. 6 (June 2001): 1139–49. http://dx.doi.org/10.1175/1520-0477(2001)082<1139:uanaar>2.3.co;2.

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14

Ware, R. "UNAVCO and UCAR join forces." Eos, Transactions American Geophysical Union 72, no. 26 (1991): 277. http://dx.doi.org/10.1029/90eo00221.

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15

Lebowitz, M. R., A. M. Moses, and S. J. Scheinman. "Effects of atrial natriuretic peptides on metabolism of arginine vasopressin by isolated perfused rat kidney." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 263, no. 2 (August 1, 1992): R273—R278. http://dx.doi.org/10.1152/ajpregu.1992.263.2.r273.

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Atrial natriuretic peptide (ANP) antagonizes the release and action of arginine vasopressin (AVP) both in vivo and in vitro. We have reported that ANP increases the urinary and metabolic clearances of AVP in normal subjects (A. M. Moses et al. J. Clin. Endocrinol. Metab. 70: 222-229, 1990). To clarify this effect, we perfused isolated rat kidneys in vitro and measured the clearances of AVP for 30 min after the addition of rat ANP [rANP-(1-28), 10(-7) M]. In the perfused kidney, rANP increased the urinary clearance of AVP (UCAVP) from 321 +/- 19 to 417 +/- 20 microliters/min (P less than 0.01) and increased the glomerular filtration rate (GFR) from 558 +/- 28 to 696 +/- 28 microliters/min (P less than 0.01). Fractional excretion of AVP was unchanged. Rates of AVP reabsorption were directly related to filtered AVP, and this relationship was not altered by ANP. ANP did not affect the total organ clearance or the renal metabolic clearance of AVP. The increase in GFR was associated with increases in renal vascular resistance (P less than 0.05), filtration fraction (P less than 0.01), and sodium excretion (P less than 0.001). UCAVP also increased when GFR was raised without ANP by perfusing at higher pressures. The rat ANP clearance receptor agonist [cANP- (4-23), 10(-7) M] did not change GFR or UCAVP. ANP increases UCAVP in the isolated perfused rat kidney. This appears to be a hemodynamic effect of ANP, acting through its biological receptor and not the clearance receptor.(ABSTRACT TRUNCATED AT 250 WORDS)
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Sun, Di, Qijie Lu, Cong Wei, Yi Li, Yuanyi Zheng, and Bing Hu. "Differential diagnosis of <3 cm renal tumors by ultrasonography: a rapid, quantitative, elastography self-corrected contrast-enhanced ultrasound imaging mode beyond screening." British Journal of Radiology 93, no. 1112 (August 2020): 20190974. http://dx.doi.org/10.1259/bjr.20190974.

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Objectives: To assess the combined diagnostic strategy of contrast-enhanced ultrasound (CEUS) and acoustic radiation force impulse (ARFI) in the precise differential diagnosis of clear cell renal cell carcinoma (CCRCC) and urothelium carcinoma of the renal pelvis (UCRP) with other small renal tumors (SRTs) ＜3 cm in size. Methods: The elastography self-corrected CEUS (ESC) mode was established to perform the quantitative differential diagnosis of SRTs (<3 cm). The kidney shear wave velocity (SWV) value recorded by ARFI showed substantial variability in patients with CCRCC (high elasticity value) and UCRP (low elasticity value) compared with other renal masses, thus providing critical self-correction information for the ultrasound differential diagnosis of SRTs. Results: In this work, the ESC observations and the corresponding ESC criteria show a remarkable 94.6% accuracy in reference to the gold standards, thus allowing the quantitative, early triple distinction of CCRCC with UCRP and other SRTs in patients with suspicious SRTs. Conclusions: This ARFI self-corrected CEUS diagnostic strategy is far beyond a screening method and may have the potential to identify a window of therapeutic opportunity in which emerging therapies might be applied to patients with CCRCC and UCRP, reducing overtreatment and medical costs. Advances in knowledge: In our study, a new rapid and non-invasive elastography self-corrected CEUS (ESC) ultrasound imaging mode was developed, which was useful in the triple distinction of CCRCC, UCRP, and other SRTs with 94.6% accuracy. ESC is a promising method in the differential diagnosis of SRTs with accuracy and practicability far beyond a single screening model.
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Gorbunov, Michael E., A. V. Shmakov, Stephen S. Leroy, and Kent B. Lauritsen. "COSMIC Radio Occultation Processing: Cross-Center Comparison and Validation." Journal of Atmospheric and Oceanic Technology 28, no. 6 (June 1, 2011): 737–51. http://dx.doi.org/10.1175/2011jtecha1489.1.

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Abstract A radio occultation data processing system (OCC) was developed for numerical weather prediction and climate benchmarking. The data processing algorithms use the well-established Fourier integral operator–based methods, which ensure a high accuracy of retrievals. The system as a whole, or in its parts, is currently used at the Global Navigation Satellite System Receiver for Atmospheric Sounding (GRAS) Satellite Application Facility at the Danish Meteorological Institute, German Weather Service, and Wegener Center for Climate and Global Change. A statistical comparison of the inversions of the Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC) data by the system herein, University Corporation for Atmospheric Research (UCAR) data products, and ECMWF analyses is presented. Forty days of 2007 and 2008 were processed (from 5 days in the middle of each season) for the comparison of OCC and ECMWF, and 20 days of April 2009 were processed for the comparison of OCC, UCAR, and ECMWF. The OCC and UCAR inversions are consistent. For the tropics, the systematic difference between OCC and UCAR in the retrieved refractivity in the 2–30-km height interval does not exceed 0.1%; in particular, in the 9–25-km interval it does not exceed 0.03%. Below 1 km in the tropics the OCC – UCAR bias reaches 0.2%, which is explained by different cutoff and filtering schemes implemented in the two systems. The structure of the systematic OCC – ECMWF difference below 4 km changes in 2007, 2008, and 2009, which is explained by changes in the ECMWF analyses and assimilation schemes. It is estimated that in the 4–30-km height range the OCC occultation processing system obtains refractivities with a bias not exceeding 0.2%. The random error ranges from 0.3%–0.5% in the upper troposphere–lower stratosphere to about 2% below 4 km. The estimate of the bias below 4 km can currently be done with an accuracy of 0.5%–1% resulting from the structural uncertainty of the radio occultation (RO) data reflecting the insufficient knowledge of the atmospheric small-scale structures and instrumental errors. The OCC – UCAR bias is below the level of the structural uncertainty.
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18

Lamptey, Benjamin L., Rajul E. Pandya, Thomas T. Warner, Rebecca Boger, Roelof T. Bruintjes, Paul A. Kucera, Arlene Laing, et al. "INTERNATIONAL RELATIONS: The Ucar Africa Initiative." Bulletin of the American Meteorological Society 90, no. 3 (March 2009): 299–303. http://dx.doi.org/10.1175/2008bams2452.1.

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19

Sami, Slama, Sihem Nasri, Bassam Zafar, and Adnane Cherif. "Multi-Input Single-Output State Space for Hybrid Power System Approach Using PEMFC." International Journal of Energy Optimization and Engineering 6, no. 4 (October 2017): 35–50. http://dx.doi.org/10.4018/ijeoe.2017100103.

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This paper presents the utilization of an Ultra-capacitor as an auxiliary power source in a hybrid power system, composed of a Polymer Electrolyte Membrane Fuel Cell (PEMFC) as a main energy source. The PEMFC source may not be sufficient to satisfy the power required, especially, the peak demand periods. So, we use an Ultra-Capacitor (UCap) because it offers a very fast power response and a high specific power. In addition, the UCap can round off the slowdown of the main source output power to produce the effectiveness and performance characteristics needed to a variable load. A regulation for the PEMFC and the UCap was given. Furthermore, a Power Management Unit (PMU) is proposed in order to reach the good functioning of the system. The analysis and the evaluation of the PMU is performed through simulation results to verify the reliability and the effectiveness of the proposed system using Matlab/Simulink environment.
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Ramírez Espinoza, Martha Aurora. "Entrevista al Dr. Claudio Hugo Fede." Revista del Posgrado en Derecho de la UNAM, no. 16 (July 1, 2022): 20. http://dx.doi.org/10.22201/ppd.26831783e.2022.16.203.

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Claudio Hugo Fede, Juez del Juzgado de Primera Instancia en lo Civil y Comercial N° 7 del Departamento Judicial de Gral. San Martín, Poder Judicial de la Provincia de Buenos Aires. Abogado Universidad de Buenos Aires (UBA). Especialista en Problemáticas de las Organizaciones Familiares (UNSAM). Investigador en Derecho en la Universidad Católica de la Plata (UCALP). Ex Director de la carrera de abogacía en la Facultad de Derecho y Ciencias Políticas de la Universidad Católica de La Plata (UCALP). Director de Revista Argentina de Derecho Común. Co-Director de la Revista Argentina de Derecho y Tecnología, de IJ Editores. Profesor Titular de la materia Derecho Privado y en la materia Teoría del Proceso, en la Universidad Católica de La Plata (UCALP). Profesor adjunto en la materia Derecho de Familia y en la materia Interpretación del Derecho, en Universidad Abierta Interamericana (UAI). Co-Director y Profesor de la Diplomatura “Nuevas Competencias en Escenarios de Cambio” dictada dentro del Instituto de Estudios en Ciencias Jurídicas de la Universidad de Gral. San Martín (UNSAM). Coordinador – Docente del “Curso de Capacitación al Poder Judicial de la Provincia de Buenos Aires”. Presidente de la Asociación de Magistrados y Funcionarios del Departamento Judicial de General San Martín. Representante del Colegio de Magistrados y Funcionarios de la Provincia de Buenos Aires ante la Federación Argentina de la Magistratura y la Función Judicial. Autor de obras jurídicas, literarias y artículos de diversas especialidades y áreas.
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Chew, Clara, and Eric Small. "Description of the UCAR/CU Soil Moisture Product." Remote Sensing 12, no. 10 (May 14, 2020): 1558. http://dx.doi.org/10.3390/rs12101558.

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Currently, the ability to use remotely sensed soil moisture to investigate linkages between the water and energy cycles and for use in data assimilation studies is limited to passive microwave data whose temporal revisit time is 2–3 days or active microwave products with a much longer (>10 days) revisit time. This paper describes a dataset that provides soil moisture retrievals, which are gridded to 36 km, for the upper 5 cm of the soil surface at sparsely sampled 6-hour intervals for +/− 38 degrees latitude for 2017–present. Retrievals are derived from the Cyclone Global Navigation Satellite System (CYGNSS) constellation, which uses GNSS-Reflectometry to obtain L-band reflectivity observations over the Earth’s surface. The product was developed by calibrating CYGNSS reflectivity observations to soil moisture retrievals from NASA’s Soil Moisture Active Passive (SMAP) mission. Retrievals were validated against observations from 171 in-situ soil moisture probes, with a median unbiased root-mean-square error (ubRMSE) of 0.049 cm3 cm−3 (standard deviation = 0.026 cm3 cm−3) and median correlation coefficient of 0.4 (standard deviation = 0.27). For the same stations, the median ubRMSE between SMAP and in-situ observations was 0.045 cm3 cm−3 (standard deviation = 0.025 cm3 cm−3) and median correlation coefficient was 0.69 (standard deviation = 0.27). The UCAR/CU Soil Moisture Product is thus complementary to SMAP, albeit with a larger random noise component, providing soil moisture retrievals for applications that require faster revisit times than passive microwave remote sensing currently provides.
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Basu, Arunabha, Ajay Makkuni, S. James Zhou, and Howard S. Meyer. "Economic Evaluation of the UCSRP-HP Process in IGCC Applications." International Journal of Clean Coal and Energy 02, no. 03 (2013): 25–34. http://dx.doi.org/10.4236/ijcce.2013.23004.

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Zhang, Bin, Shu-peng Ho, Changyong Cao, Xi Shao, Jun Dong, and Yong Chen. "Verification and Validation of the COSMIC-2 Excess Phase and Bending Angle Algorithms for Data Quality Assurance at STAR." Remote Sensing 14, no. 14 (July 8, 2022): 3288. http://dx.doi.org/10.3390/rs14143288.

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In recent years, Global Navigation Satellite System (GNSS) radio occultation (RO) has become a critical observation system for global operational numerical weather prediction. Constellation Observing System for Meteorology, Ionosphere, Climate (COSMIC) 2 (COSMIC-2) has been a backbone RO mission for NOAA. NOAA also began to purchase RO data from commercial sources in 2020. To ensure the consistent quality of RO data from different sources, NOAA Center for Satellite Applications and Research (STAR) has developed capabilities to process all available RO data from different missions. This paper describes the STAR RO processing systems which convert the pseudo-range and carrier phase observations to excess phases and bending angles (BAs). We compared our COSMIC-2 data products with those processed by the University Corporation for Atmospheric Research (UCAR) COSMIC Data Analysis and Archive Center (CDAAC). We processed more than twelve thousand COSMIC-2 occultation profiles. Our results show that the excess phase difference between UCAR and STAR is within a few centimeters at high altitudes, although the difference increases towards the lower atmosphere. The BA profiles derived from the excess phase are consistent with UCAR. The mean relative BA differences at impact height from 10 to 30 km are less than 0.1% for GLObal NAvigation Satellite System (GLONASS) L2C signals and Global Positioning System (GPS) L2C and L2P signals. The standard deviations are 1.15%, 1.15%, and 1.32% for GLONASS L2C signal and for GPS L2C and L2P signals, respectively. The BA profiles agree with those derived from European Center for Medium-range Weather Forecast (ECMWF) reanalysis version 5 (ERA5). The Signal-to-Noise-Ratio (SNR) plays an essential role in the processing. The STAR BA profiles with higher L1 SNRs (L1 at 80 km) tend to yield more consistent results than those from UCAR, with a negligible difference and a smaller deviation than lower SNR profiles. Profiles with lower SNR values tend to show a more significant standard deviation towards the surface during the open-loop stage in the lower troposphere than those of higher SNR. We also found that the different COSMIC-2 clock solutions could contribute to the significant relative BA difference at high altitudes; however, it has little effect on the lower troposphere comparisons given larger BA values.
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Kendall, Filipa, Gustavo Silva, João Almeida, Ermelinda Eusébio, Paulo Pinho, Jose Oliveira, and Pedro Teixeira Bastos. "Influence of Respiratory Muscle Training on Patients’ Recovery after Lung Resection." International Journal of Sports Medicine 41, no. 07 (April 6, 2020): 484–91. http://dx.doi.org/10.1055/a-1096-0913.

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AbstractThis prospective experimental study aimed to compare effects of 3 different home-based postoperative respiratory muscle training protocols – inspiratory, expiratory and combined, in the patients’ postoperative recovery, regarding safety and respiratory muscle function, pulmonary function, physical fitness, physical activity (PA), dyspnoea and quality of life (QoL). Patients were divided in four groups Usual Care (UCare), inspiratory (IMT), expiratory (EMT) or combined muscle training (CombT) according to group allocation. Significant treatment*time interactions were found for maximal inspiratory pressure (MIP) (p=0.014), sedentary PA (SEDPA) (p=0.003), light PA (LIGPA) (p=0.045) and total PA (p=0.035). Improvements were observed for MIP in CombT (p=0.001), IMT (p=0.001), EMT (p=0.050). SEDPA reduced in EMT (p=0.001) and IMT (p=0.006), while LIGPA increased in both groups (p=0.001), as well as Total PA (p=0.005 and p=0.001, respectively). In UCare, CombT, and EMT, QoL improved only for Usual Activities. In conclusion, the addition of respiratory muscle training to physiotherapy usual care is safe and effective to increase MIP and contribute to improve physical activity. The CombT showed greater improvement on MIP, while IMT compared to EMT, was more effective to improve physical activity.
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Marrow, Steven P., and Edgar F. Kent. "Developing a benefits vendor-management program at UCAR international." Employment Relations Today 23, no. 3 (September 1996): 35–46. http://dx.doi.org/10.1002/ert.3910230305.

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Sadida, Faza Lisan, Muhammad Rady Irawan, Miranti Indar Mandasari,, and Suprijanto Suprijanto. "Studi Korelasi Sinyal Motorik Otot Wajah dan Sinyal Suara Ucap pada Artikulasi Fonem Vokal." Jurnal Otomasi Kontrol dan Instrumentasi 13, no. 2 (2021): 109–15. http://dx.doi.org/10.5614/joki.2021.13.2.6.

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Perubahan bentuk artikulator memiliki pengaruh pada suara ucap yang dihasilkan, sehingga setiap fonem memiliki karakteristik pola artikulasi yang berbeda. Penelitian ini meninjau hubungan otot artikulator wajah dengan sinyal suara ucap yang dihasilkan pada proses artikulasi fonem vokal. Digunakan 4 elektroda untuk merekam sinyal otot yang diletakkan pada otot depressor anguli oris dan zygomaticus major berdasarkan hasil analisa optical flow citra wajah saat mengucapkan fonem vokal. Dilakukan korelasi silang pada setiap pasang envelope sinyal EMG untuk mengetahui kecenderungan bentuk artikulator pada proses artikulasi. Diperoleh hasil bahwa setiap responden memiliki kecenderungan pola kontraksi pada otot artikulator yang unik, dan terdapat sinkronisasi untuk keempat titik artikulator yang ditandai dengan rendahnya nilai delay hasil korelasi silang untuk keempat pasang elektroda. Selain itu, dilakukan pula analisis total energi kontraksi yang dibutuhkan untuk menggerakkan, menahan serta mengembalikan posisi artikulator pada proses artikulasi. Berdasarkan analisa perbandingan energi, diperoleh hasil bahwa kontribusi otot depressor anguli oris lebih dominan dibandingkan otot zygomaticus major pada proses artikulasi fonem vokal.
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Sakrim, Sakrim. "Distribusi, Pelepasan, dan Perubahan Fonem [R] dalam Komunikasi Anak Usia 3 Tahun." Stilistika: Jurnal Pendidikan Bahasa dan Sastra 13, no. 2 (July 31, 2020): 234. http://dx.doi.org/10.30651/st.v13i2.4857.

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ABSTRAKAlat ucap sangat mendominasi terhadap ketepatan dalam mendistribusikan dan pelepasan fonem. Ketika alat ucap tidak sempurna maka akan memberi efek bagi lingual. Distribusi dan pelepasan fonem tidak akan semestinya tepat dan benar jika alat ucap sebagai elemen pendukung tidak sempurna. Alat ucap yang terdepan membantu untuk merealisasikan keluarnya bunyi fonem yang diharapkan khususnya fonem [R], hal ini sering terjadi pada anak usia dini. Anak usia 3 tahun bisa mendistribusikan fonem-fonem yang ringan untuk dikomunikasikan. Anak usia 3 tahun alat ucapnya tidak sempurna seperti orang dewasa. Ketidaksempurnaan alat bicara sangat mempengaruhi terhadap bicara anak khususnya untuk mendistribusikan fonem-fonem yang sulit seperti fonem [R], [S], dan [F]. Problem seperti itu terjadi bukan hanya di pedesaan, di daerah kota masih banyak temuan dalam berkomunikasi anak tidak bisa menggunakan fonem [R]. Pengumpulan data dalam penelitian ini yaitu, metode simak, rekam, dan catat. Berdasarkan hasil penelitian yang dilakukan ditemukan beberapa data kesalahan pelepasan bunyi fonem [R] di awal kata, kesalahan pelepasan bunyi fonem [R] di tengah kata, dan kesalahan pelepasan bunyi fonem [R] di akhir kata. Kata kunci: Pemerolehan Bahasa, anak usia 3 tahun,distribusi ABSTRACTThe speech instrument dominates the accuracy in distributing and releasing phonemes. When the utterance is not perfect, it will have an effect on the lingual. The distribution and releasing phonemes will not be appropriate and correc,t if the speech device, as supporting element, is not perfect. The the front speech device helps to realize the expected phoneme sounds, especially phonemes [R], this often occurs in early childhood. 3 years old children can distribute light phonemes to be communicated. A 3-year-old child speech is not as perfect as an adult. Speech device imperfections are very influential on children's speech, especially to distribute difficult phonemes such as [R], [S], and [F] phonemes. This problem does not occur only in rural areas, in urban areas there are still many findings in children cannot communicate using phonemes [R]. Data collection in this research is analytic method, recording, and taking note. Based on the results of conducting research found that some data errors in the release of phonemes [R] at the beginning of words, errors in releasing phonemes [R] in the middle of words, and errors in releasing phonemes [R] at the end of words.Keyword: Language acquisition, 3-year-old child, distribution
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Pigazzani, Filippo, Davide Gorni, Kenneth A. Dyar, Matteo Pedrelli, Gwen Kennedy, Gabriele Costantino, Agostino Bruno, et al. "The Prognostic Value of Derivatives-Reactive Oxygen Metabolites (d-ROMs) for Cardiovascular Disease Events and Mortality: A Review." Antioxidants 11, no. 8 (August 9, 2022): 1541. http://dx.doi.org/10.3390/antiox11081541.

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Oxidative stress participates in the development and exacerbation of cardiovascular diseases (CVD). The ability to promptly quantify an imbalance in an individual reductive-oxidative (RedOx) state could improve cardiovascular risk assessment and management. Derivatives-reactive oxygen metabolites (d-ROMs) are an emerging biomarker of oxidative stress quantifiable in minutes through standard biochemical analysers or by a bedside point-of-care test. The current review evaluates available data on the prognostic value of d-ROMs for CVD events and mortality in individuals with known and unknown CVD. Outcome studies involving small and large cohorts were analysed and hazard ratio, risk ratio, odds ratio, and mean differences were used as measures of effect. High d-ROM plasma levels were found to be an independent predictor of CVD events and mortality. Risk begins increasing at d-ROM levels higher than 340 UCARR and rises considerably above 400 UCARR. Conversely, low d-ROM plasma levels are a good negative predictor for CVD events in patients with coronary artery disease and heart failure. Moreover, combining d-ROMs with other relevant biomarkers routinely used in clinical practice might support a more precise cardiovascular risk assessment. We conclude that d-ROMs represent an emerging oxidative-stress-related biomarker with the potential for better risk stratification both in primary and secondary cardiovascular prevention.
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"Ucart-123." Reactions Weekly 1937, no. 1 (December 17, 2022): 449. http://dx.doi.org/10.1007/s40278-022-30129-1.

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30

"UCAR/NCAR Anniversary." Bulletin of the American Meteorological Society 67, no. 4 (April 1986): 390–401. http://dx.doi.org/10.1175/1520-0477-67.4.390.

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31

Lin, Haolong, Jiali Cheng, Wei Mu, Jianfeng Zhou, and Li Zhu. "Advances in Universal CAR-T Cell Therapy." Frontiers in Immunology 12 (October 6, 2021). http://dx.doi.org/10.3389/fimmu.2021.744823.

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Chimeric antigen receptor T (CAR-T) cell therapy achieved extraordinary achievements results in antitumor treatments, especially against hematological malignancies, where it leads to remarkable, long-term antineoplastic effects with higher target specificity. Nevertheless, some limitations persist in autologous CAR-T cell therapy, such as high costs, long manufacturing periods, and restricted cell sources. The development of a universal CAR-T (UCAR-T) cell therapy is an attractive breakthrough point that may overcome most of these drawbacks. Here, we review the progress and challenges in CAR-T cell therapy, especially focusing on comprehensive comparison in UCAR-T cell therapy to original CAR-T cell therapy. Furthermore, we summarize the developments and concerns about the safety and efficiency of UCAR-T cell therapy. Finally, we address other immune cells, which might be promising candidates as a complement for UCAR-T cells. Through a detailed overview, we describe the current landscape and explore the prospect of UCAR-T cell therapy.
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Mulyana, Salsabila Delaria. "GANGGUAN BERBAHASA AKIBAT ALAT UCAP PADA ANAK USIA 9 TAHUN." SASTRANESIA: Jurnal Program Studi Pendidikan Bahasa dan Sastra Indonesia 8, no. 1 (March 29, 2020). http://dx.doi.org/10.32682/sastranesia.v8i1.1367.

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Bahasa anak adalah bahasa yang sangat luas karena pada masa ini anak dibebaskan menyerap semua informasi tanpa ada penyaringan yang bersifat wajib. Banyak orang dewasa yang terpesona melihat kemampuan anak dalam pemerolehan bahasa yang begitu luas. Semua informasi bisa diperoleh anak darimanapun. Akan tetapi dalam proses pemerolehan bahasa, tidak semua anak dapat menerimanya dengan sempurna. Terdapat beberapa anak yang memiliki gangguan berbahasa dalam proses belajarnya. Salah satu penyebab gangguan berbahasa pada anak adalah akibat tidak sempurnanya alat ucap yang dimiliki. Penelitian ini akan membahas penyebab gangguan berbicara pada anak usia 9 tahun akibat alat ucap. Tujuan penelitian ini adalah untuk mengetahui dan memperbaiki gangguan berbahasa yang terjadi akibat alat ucap pada anak. Metode penelitian ini adalah deskriptif kualitatif dengan objek penelitian fokus kepada anak laki-laki usia 9 tahun yang memiliki gangguan berbahasa. Data yang diteliti berbentuk audio, video beserta transkrip percakapan antara peneliti dan objek sekaligus kawan tutur dalam percakapan tersebut. Adapun hasil penelitiannya yaitu (1) Gangguan berbahasa pada anak usia 9 tahun yang diucapkan oleh alat ucap adalah ketidaksempurnaan pada bagian laringal, (2) Faktor lingkungan juga dapat menentukan bagaimana alat ucap dapat menjadi gangguan atau sebaliknya yang mendukung proses pemerolehan bahasa.
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"Arkema completes acquisition of UCAR." Pigment & Resin Technology 39, no. 4 (July 6, 2010). http://dx.doi.org/10.1108/prt.2010.12939dab.003.

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Setiawan, Hendra, Slamet Triyadi, Dewi Herlina, Aisyah Asharini Nur Fadilah, Alma Lutfiyana, Tralleta Elkana Hayashi, and Nining Nursakinah. "Penerapan Mekanisme Berbicara pada Penderita Disartria Menggunakan Media Audio Visual." Majalah Ilmiah UPI YPTK, June 24, 2022, 54–59. http://dx.doi.org/10.35134/jmi.v29i1.101.

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Gangguan bicara bisa dialami oleh siapa saja dan disebabkan oleh banyak faktor, di antaranya gangguan berdasarkan faktor medis dan lingkungan. Faktor medis yang mempengaruhi proses berbicara adalah kelainan fungsi otak dan saraf seperti penderita stroke, sementara faktor lingkungan bisa menyebabkan kelainan berbicara karena pembiasaan, seperti tidak dibiasakan berbicara dan mendengar, kondisi terisolasi, atau tersisihkan dari lingkungan manusia. Dalam penelitian ini akan membahas tentang gangguan berbicara yang disebabkan oleh perkembangan alat ucap yang belum sempurna pada anak usia PAUD, perkembangan alat ucap ini masuk dalam faktor medis, yang mana organ ucap belum berkembang sempurna di usia balita, namun seiring dengan perkembangan usia, alat ucap akan berkembang dengan sempurna dan matang pada waktunya. Menggunakan penelitian deskriptif kualitatif, penelitian ini akan menjelaskan tentang bagaimana siswa PAUD An-Nuur Kalri, Karawang memperoleh pembelajaran bahasa di sekolah dan di rumah, serta penjelasan mengenai beberapa anak yang cadel, yang mana termasuk dalam gangguan berbicara sebagaimana topik penelitian ini. Penelitian ini dilaksanakan melalui empat tahapan dan disimpulkan dengan hasil penelitian serta saran terapi dan pembiasaan bagi anak-anak sejak dini agar proses pemerolehan bahasa yang dialaminya lebih sempurna di usia muda.
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Fredsøe, Jacob, Martin Rasmussen, Amy L. Tin, Andrew J. Vickers, Michael Borre, Karina D. Sørensen, and Hans Lilja. "Predicting Grade group 2 or higher cancer at prostate biopsy by 4Kscore in blood and uCaP microRNA model in urine." Scientific Reports 12, no. 1 (September 7, 2022). http://dx.doi.org/10.1038/s41598-022-19460-6.

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AbstractElevated prostate-specific antigen (PSA) levels often lead to unnecessary and possibly harmful transrectal ultrasound guided biopsy, e.g. when the biopsy is negative or contains only low-grade insignificant cancer, unlikely to become symptomatic in the man’s normal lifespan. A model based on four-kallikrein markers in blood (commercialized as 4Kscore) predicts risk of Grade group 2 or higher prostate cancer at biopsy, reducing unnecessary biopsies. We assessed whether these results extend to a single institution prostate biopsy cohort of Danish men and are enhanced by three microRNAs from urine (referred to as uCaP). The 4Kscore measured in cryopreserved blood from 234 men referred for 10+ core biopsy to Aarhus University Hospital, 29 with PSA > 25 ng/ml. We explored uCaP in urine from 157 of these men. Combined with age and DRE findings, both 4Kscore and uCaP could accurately predict Grade group 2 or higher prostate cancer (all patients: AUC = 0.802 and 0.797; PSA ≤ 25: AUC = 0.763 and 0.759). There was no additive effect when combining the 4Kscore and uCaP. Limitations include a study cohort with higher risk than commonly reported for biopsy cohorts. Our findings further support the clinical use of the 4Kscore to predict Grade group 2 or higher cancers in men being considered for biopsy.
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Li, Wuling, Xiuxiu Zhu, Yanmin Xu, Jun Chen, Hongtao Zhang, Zhi Yang, Yanan Qi, et al. "Simultaneous editing of TCR, HLA-I/II and HLA-E resulted in enhanced universal CAR-T resistance to allo-rejection." Frontiers in Immunology 13 (December 2, 2022). http://dx.doi.org/10.3389/fimmu.2022.1052717.

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IntroductionThe major challenge for universal chimeric antigen receptor T cell (UCAR-T) therapy is the inability to persist for a long time in patients leading to inferior efficacy clinically. The objective of this study was to design a novel UCAR-T cell that could avoid the occurrence of allo-rejection and provide effective resistance to allogeneic Natural Killer (NK) cell rejection, together with the validation of its safety and efficacy ex vivo and in vivo.MethodsWe prepared T-cell receptor (TCR), Human leukocyte antigen (HLA)-I/II triple-edited (TUCAR-T) cells and evaluated the anti-tumor efficacy ex vivo and in vivo. We measured the resistance of exogenous HLA-E expressing TUCAR-T (ETUCAR-T) to NK rejection by using an enhanced NK. Furthermore, we established the safety and efficacy of this regimen by treating Nalm6 tumor-bearing mice with a repeated high-dose infusion of ETUCAR-T. Moreover, we analyzed the effects of individual gene deficiency CAR-T on treated mice and the changes in the transcriptional profiles of different gene-edited T cells via RNA-Seq.ResultsData showed that HLA-II editing didn’t impair the anti-tumor efficacy of TUCAR-T ex vivo and in vivo and we found for the first time that HLA-II deficiency could facilitate the persistence of CAR-T. Contrastively, as the most commonly eliminated target in UCAR-T, TCR deficiency was found to be a key disadvantageous factor for the shorter-term anti-tumor efficacy in vivo. Our study demonstrated ETUCAR-T could effectively resist allogeneic NK rejection ex vivo and in vivo.DiscussionOur research provided a potential and effective strategy for promoting the persistence of UCAR-T cells in clinical application. And it reveals the potential key factors of the poor persistence of UCAR-T along with new insights for future development.
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"PBMC Donation in UCAR-T Cells." Case Medical Research, September 17, 2019. http://dx.doi.org/10.31525/ct1-nct04091906.

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Hernandez-Quiles, Carlos, Máximo Bernabeu-Wittel, Bosco Barón-Franco, Alfonso Aguirre Palacios, M. Rocio Garcia-Serrano, Wilfredo Lopez-Jimeno, Jose Antonio Perez-de-Leon-Serrano, et al. "A randomized clinical trial of home telemonitoring in patients with advanced heart and lung diseases." Journal of Telemedicine and Telecare, December 1, 2021, 1357633X2110597. http://dx.doi.org/10.1177/1357633x211059707.

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Brief Summary The addition of home monitoring to an integrated care model in patients with advanced chronic heart/lung diseases decreases mortality, hospital and emergency admissions, improves functional status, HRQoL, and is cost-effective. Background Telemonitoring is a promising implement for medicine, but its efficacy is unknown in patients with advanced heart and lung failure (AHLF). Objective To determine the efficacy of a telemonitoring system added to coordinated clinical care in patients with AHLF. Design Randomized phase 3 multicenter clinical trial with parallel groups in adult patients. Participants Five spanish centers including patients with AHLF at discharge or in out-patient clinics. Intervention Patients were randomly assigned to receive a remote bio-parameters telemonitoring system (TELECARE) or best usual care (UCARE). TELECARE patients were provided with devices that collected symptoms and bio-parameters, and transferred them synchronously to a call-center, with a real-time health-care response. Main Measures Primary end point was the need of admissions/emergency room visits at 45, 90, 180 days. Secondary end points included health care requirements, mortality, functional assessment, health related quality of life (HRQoL), perceived satisfaction, and cost-efficacy. Results 510 patients were included (54.5% women, median age 76.5 years; 63.1% suffered heart failure, 13.9% lung failure, and 22.9% both conditions). Clinical and functional features were comparable in both arms. TELECARE globally needed less admissions with respect UCARE after 45 days of inclusion (35.4% vs. 46.9%, p < 0.05). This tendency was maintained in the subgroups of patients with multimorbidity (34.2% vs. 46.9%, p < 0.05), intermediate risk of mortality (36.5% vs. 51.1%, p < 0.05), and those included after hospital discharge (34.9% vs. 50.5%, p < 0.01). HRQoL significantly improved (TELECARE/UCARE EuroQol baseline of 56.2 ± 18.2/55.1 ± 19.7, p = 0.054, and 64 ± 19.9/56.3 ± 21.6; p < 0.01 at the end), and perceived satisfaction was also higher (6.77 ± 0.52 vs. 6.62 ± 0.81, p < 0.001; highest possible score = 7). A trend to mortality decrease was also observed (12.9% vs. 19.3%, p = 0.13). TELECARE was cost-efficacious (TELECARE/UCARE QALY 3.94 Euros/0.81Euros). Conclusions The addition of a telemonitoring system to an integrated care model in patients with AHLF decreases hospital and emergency admissions, improves functional status as well as HRQoL, and is cost-efficacious.
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"Ucar v Nylex Industrial Products Pty Ltd." Victorian Reports 17 VR (2007): 492–527. http://dx.doi.org/10.25291/vr/17-vr-492.

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"UCAR Colloquium on Advances in Ecosystem‐Atmosphere Interactions." Bulletin of the Ecological Society of America 78, no. 2 (April 1997): 164–65. http://dx.doi.org/10.2307/20168149.

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Showstack, Randy. "New UCAR Leader Sees Scientific, Administrative Challenges Ahead." Eos, February 22, 2017. http://dx.doi.org/10.1029/2017eo068403.

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Saha, Saurav Bhaskar, Vijai Kumar Gupta, and Pramod Wasudeo Ramteke. "uCARE Chem Suite and uCAREChemSuiteCLI: Tools for bacterial resistome prediction." Genes & Diseases, June 2020. http://dx.doi.org/10.1016/j.gendis.2020.06.008.

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43

Nalbantgil, Sanem. "İleri evre kalp yetersizliği rehberi." Updates in Cardiology 1, no. 1 (2018). http://dx.doi.org/10.5543/ucard.2018.43153.

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44

ilerigelen, Barış. "Beta-blockers in cardiovascular prevention." Updates in Cardiology, 2019. http://dx.doi.org/10.5543/ucard.2019.00719.

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45

Sinan, Ümit Yaşar. "Diet and lifestyle modifications." Updates in Cardiology, 2020. http://dx.doi.org/10.5543/ucard.2019.02996.

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46

Başaran, Özcan. "Statin Intolerance." Updates in Cardiology, 2020. http://dx.doi.org/10.5543/ucard.2019.09719.

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47

Güngör, Barış. "Lipid lowering therapy in particular patient populations." Updates in Cardiology, 2020. http://dx.doi.org/10.5543/ucard.2019.09797.

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48

Komşuoğlu Çelikyurt, İpek. "Pharmacological properties of nebivolol." Updates in Cardiology, 2019. http://dx.doi.org/10.5543/ucard.2019.21931.

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49

Tokgözoğlu, Lale. "Introduction to 2019 ESC/EAS Guidelines for the management of Dyslipidema." Updates in Cardiology, 2020. http://dx.doi.org/10.5543/ucard.2019.25744.

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50

Temizhan, Ahmet. "Nebivolol in heart failure teatment." Updates in Cardiology, 2019. http://dx.doi.org/10.5543/ucard.2019.33042.

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